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Stroke Res."],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract\n<\/jats:title><jats:p>Candidate gene studies have identified genetic variants associated with clinical outcomes following aneurysmal subarachnoid haemorrhage (aSAH), but no genome-wide association studies have been performed to date. Here we report the results of the discovery phase of a two-stage genome-wide meta-analysis of outcome after aSAH. We identified 157 independent loci harbouring 756 genetic variants associated with outcome after aSAH (<jats:italic>p<\/jats:italic>\u2009&lt;\u20091\u2009\u00d7\u200910<jats:sup>\u22124<\/jats:sup>), which require validation. A single variant (rs12949158), in <jats:italic>SPNS2<\/jats:italic>, achieved genome-wide significance (<jats:italic>p<\/jats:italic>\u2009=\u20094.29\u2009\u00d7\u200910<jats:sup>\u22128<\/jats:sup>) implicating sphingosine-1-phosphate signalling in outcome after aSAH. A large multicentre international effort to recruit samples for validation is required and ongoing. 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