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Stroke Res."],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract\n<\/jats:title><jats:p>Rising intracranial pressure (ICP) aggravates secondary injury and heightens risk of death following intracerebral hemorrhage (ICH). Long-recognized compensatory mechanisms that lower ICP include reduced cerebrospinal fluid and venous blood volumes. Recently, we identified another compensatory mechanism in severe stroke, a decrease in cerebral parenchymal volume via widespread reductions in cell volume and extracellular space (tissue compliance). Here, we examined how age affects tissue compliance and ICP dynamics after severe ICH in rats (collagenase model). A planned comparison to historical young animal data revealed that aged SHAMs (no stroke) had significant cerebral atrophy (9% reduction, <jats:italic>p<\/jats:italic>\u2009\u2264\u20090.05), ventricular enlargement (9% increase, <jats:italic>p<\/jats:italic>\u2009\u2264\u20090.05), and smaller CA1 neuron volumes (21%, <jats:italic>p<\/jats:italic>\u2009\u2264\u20090.05). After ICH in aged animals, contralateral striatal neuron density and CA1 astrocyte density significantly increased (12% for neurons, 7% for astrocytes, <jats:italic>p<\/jats:italic>\u2009\u2264\u20090.05 vs. aged SHAMs). Unlike young animals, other regions in aged animals did not display significantly reduced cell soma volume despite a few trends. Nonetheless, overall contralateral hemisphere volume was 10% smaller in aged ICH animals compared to aged SHAMs (<jats:italic>p<\/jats:italic>\u2009\u2264\u20090.05). This age-dependent pattern of tissue compliance is not due to absent ICH-associated mass effect (83.2 mm<jats:sup>3<\/jats:sup> avg. bleed volume) as aged ICH animals had significantly elevated mean and peak ICP (<jats:italic>p<\/jats:italic>\u2009\u2264\u20090.01), occurrence of ICP spiking events, as well as bilateral evidence of edema (e.g., 3% in injured brain, <jats:italic>p<\/jats:italic>\u2009\u2264\u20090.05 vs. aged SHAMs). Therefore, intracranial compliance reserve changes with age; after ICH, these and other age-related changes may cause greater fluctuation from baseline, increasing the chance of adverse outcomes like mortality.<\/jats:p>","DOI":"10.1007\/s12975-022-01102-8","type":"journal-article","created":{"date-parts":[[2022,11,11]],"date-time":"2022-11-11T06:02:21Z","timestamp":1668146541000},"page":"970-986","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Intracranial Pressure Dysfunction Following Severe Intracerebral Hemorrhage in Middle-Aged Rats"],"prefix":"10.1007","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6403-1808","authenticated-orcid":false,"given":"Anna C. 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