{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T01:54:40Z","timestamp":1788573280346,"version":"build-2803163510"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T00:00:00Z","timestamp":1668643200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T00:00:00Z","timestamp":1668643200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Shanxi Province's Great Research Project","award":["201903D321044"],"award-info":[{"award-number":["201903D321044"]}]},{"name":"Shanxi Health Committee's Project","award":["2019045"],"award-info":[{"award-number":["2019045"]}]},{"name":"Shanxi Province's Basic Research Plan","award":["20210302123264"],"award-info":[{"award-number":["20210302123264"]}]},{"name":"Shanxi Province's Basic Research Plan","award":["20210302123264"],"award-info":[{"award-number":["20210302123264"]}]},{"name":"Shanxi Province's Basic Research Plan","award":["20210302123264"],"award-info":[{"award-number":["20210302123264"]}]},{"name":"Shanxi Province's Basic Research Plan","award":["20210302123264"],"award-info":[{"award-number":["20210302123264"]}]},{"name":"Shanxi Province's Basic Research Plan","award":["20210302123264"],"award-info":[{"award-number":["20210302123264"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Transl. Stroke Res."],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1007\/s12975-022-01105-5","type":"journal-article","created":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T02:03:48Z","timestamp":1668650628000},"page":"1-15","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Aerobic Glycolysis Induced by mTOR\/HIF-1\u03b1 Promotes Early Brain Injury After Subarachnoid Hemorrhage via Activating M1 Microglia"],"prefix":"10.1007","volume":"15","author":[{"given":"Xin-Gang","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Hong","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan Steve","family":"Godje Godje","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-Yu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Yu","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Bo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Juan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Sui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Jie","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,17]]},"reference":[{"issue":"6","key":"1105_CR1","doi-asserted-by":"publisher","first-page":"1623","DOI":"10.1212\/CON.0000000000000679","volume":"24","author":"S Muehlschlegel","year":"2018","unstructured":"Muehlschlegel S. Subarachnoid hemorrhage. Continuum (Minneap Minn). 2018;24(6):1623\u201357. https:\/\/doi.org\/10.1212\/CON.0000000000000679.","journal-title":"Continuum (Minneap Minn)"},{"issue":"10","key":"1105_CR2","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1007\/s11910-019-0990-3","volume":"19","author":"V Rass","year":"2019","unstructured":"Rass V, Helbok R. Early brain injury after poor-grade subarachnoid hemorrhage. Curr Neurol Neurosci Rep. 2019;19(10):78. https:\/\/doi.org\/10.1007\/s11910-019-0990-3.","journal-title":"Curr Neurol Neurosci Rep"},{"issue":"1","key":"1105_CR3","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1080\/13880209.2021.1876101","volume":"59","author":"G Xu","year":"2021","unstructured":"Xu G, Guo J, Sun C. Eucalyptol ameliorates early brain injury after subarachnoid haemorrhage via antioxidant and anti-inflammatory effects in a rat model. Pharm Biol. 2021;59(1):114\u201320. https:\/\/doi.org\/10.1080\/13880209.2021.1876101.","journal-title":"Pharm Biol"},{"issue":"1","key":"1105_CR4","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1007\/s13311-019-00772-x","volume":"17","author":"W Xu","year":"2020","unstructured":"Xu W, Mo J, Ocak U, Travis ZD, Enkhjargal B, Zhang T, et al. Activation of melanocortin 1 receptor attenuates early brain injury in a rat model of subarachnoid hemorrhage viathe suppression of neuroinflammation through AMPK\/TBK1\/NF-kappaB pathway in rats. Neurotherapeutics. 2020;17(1):294\u2013308. https:\/\/doi.org\/10.1007\/s13311-019-00772-x.","journal-title":"Neurotherapeutics"},{"key":"1105_CR5","doi-asserted-by":"publisher","first-page":"990","DOI":"10.3389\/fnins.2018.00990","volume":"12","author":"C Yang","year":"2018","unstructured":"Yang C, Li T, Xue H, Wang L, Deng L, Xie Y, et al. Inhibition of necroptosis rescues SAH-induced synaptic impairments in hippocampus via CREB-BDNF pathway. Front Neurosci. 2018;12:990. https:\/\/doi.org\/10.3389\/fnins.2018.00990.","journal-title":"Front Neurosci"},{"issue":"9","key":"1105_CR6","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1038\/nn.3469","volume":"16","author":"VE Miron","year":"2013","unstructured":"Miron VE, Boyd A, Zhao JW, Yuen TJ, Ruckh JM, Shadrach JL, et al. M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination. Nat Neurosci. 2013;16(9):1211\u20138. https:\/\/doi.org\/10.1038\/nn.3469.","journal-title":"Nat Neurosci"},{"issue":"4","key":"1105_CR7","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1038\/nrneurol.2010.17","volume":"6","author":"VH Perry","year":"2010","unstructured":"Perry VH, Nicoll JA, Holmes C. Microglia in neurodegenerative disease. Nat Rev Neurol. 2010;6(4):193\u2013201. https:\/\/doi.org\/10.1038\/nrneurol.2010.17.","journal-title":"Nat Rev Neurol"},{"issue":"11","key":"1105_CR8","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1038\/nri3086","volume":"11","author":"K Saijo","year":"2011","unstructured":"Saijo K, Glass CK. Microglial cell origin and phenotypes in health and disease. Nat Rev Immunol. 2011;11(11):775\u201387. https:\/\/doi.org\/10.1038\/nri3086.","journal-title":"Nat Rev Immunol"},{"issue":"4","key":"1105_CR9","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1002\/glia.22770","volume":"63","author":"T Tanaka","year":"2015","unstructured":"Tanaka T, Murakami K, Bando Y, Yoshida S. Interferon regulatory factor 7 participates in the M1-like microglial polarization switch. Glia. 2015;63(4):595\u2013610. https:\/\/doi.org\/10.1002\/glia.22770.","journal-title":"Glia"},{"issue":"32","key":"1105_CR10","doi-asserted-by":"publisher","first-page":"22893","DOI":"10.1074\/jbc.R113.486464","volume":"288","author":"AF McGettrick","year":"2013","unstructured":"McGettrick AF, O\u2019Neill LA. How metabolism generates signals during innate immunity and inflammation. J Biol Chem. 2013;288(32):22893\u20138. https:\/\/doi.org\/10.1074\/jbc.R113.486464.","journal-title":"J Biol Chem"},{"issue":"4","key":"1105_CR11","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1111\/bph.13139","volume":"173","author":"R Orihuela","year":"2016","unstructured":"Orihuela R, McPherson CA, Harry GJ. Microglial M1\/M2 polarization and metabolic states. Br J Pharmacol. 2016;173(4):649\u201365. https:\/\/doi.org\/10.1111\/bph.13139.","journal-title":"Br J Pharmacol"},{"issue":"1","key":"1105_CR12","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1186\/s12974-021-02187-y","volume":"18","author":"J Cheng","year":"2021","unstructured":"Cheng J, Zhang R, Xu Z, Ke Y, Sun R, Yang H, et al. Early glycolytic reprogramming controls microglial inflammatory activation. J Neuroinflammation. 2021;18(1):129. https:\/\/doi.org\/10.1186\/s12974-021-02187-y.","journal-title":"J Neuroinflammation"},{"issue":"1","key":"1105_CR13","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1186\/s13046-020-01629-4","volume":"39","author":"J Feng","year":"2020","unstructured":"Feng J, Li J, Wu L, Yu Q, Ji J, Wu J, et al. Emerging roles and the regulation of aerobic glycolysis in hepatocellular carcinoma. J Exp Clin Cancer Res. 2020;39(1):126. https:\/\/doi.org\/10.1186\/s13046-020-01629-4.","journal-title":"J Exp Clin Cancer Res"},{"issue":"7","key":"1105_CR14","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1038\/cr.2015.68","volume":"25","author":"B Kelly","year":"2015","unstructured":"Kelly B, O\u2019Neill LA. Metabolic reprogramming in macrophages and dendritic cells in innate immunity. Cell Res. 2015;25(7):771\u201384. https:\/\/doi.org\/10.1038\/cr.2015.68.","journal-title":"Cell Res"},{"issue":"3","key":"1105_CR15","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/j.cmet.2019.06.005","volume":"30","author":"SH Baik","year":"2019","unstructured":"Baik SH, Kang S, Lee W, Choi H, Chung S, Kim JI, et al. A breakdown in metabolic reprogramming causes microglia dysfunction in Alzheimer\u2019s disease. Cell Metab. 2019;30(3):493-507 e496. https:\/\/doi.org\/10.1016\/j.cmet.2019.06.005.","journal-title":"Cell Metab"},{"key":"1105_CR16","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.jns.2016.06.021","volume":"367","author":"W You","year":"2016","unstructured":"You W, Wang Z, Li H, Shen H, Xu X, Jia G, et al. Inhibition of mammalian target of rapamycin attenuates early brain injury through modulating microglial polarization after experimental subarachnoid hemorrhage in rats. J Neurol Sci. 2016;367:224\u201331. https:\/\/doi.org\/10.1016\/j.jns.2016.06.021.","journal-title":"J Neurol Sci"},{"key":"1105_CR17","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.neuroscience.2019.03.032","volume":"406","author":"XG Sun","year":"2019","unstructured":"Sun XG, Duan H, Jing G, Wang G, Hou Y, Zhang M. Inhibition of TREM-1 attenuates early brain injury after subarachnoid hemorrhage via downregulation of p38MAPK\/MMP-9 and preservation of ZO-1. Neuroscience. 2019;406:369\u201375. https:\/\/doi.org\/10.1016\/j.neuroscience.2019.03.032.","journal-title":"Neuroscience"},{"issue":"7","key":"1105_CR18","doi-asserted-by":"publisher","first-page":"1402","DOI":"10.1161\/01.str.30.7.1402","volume":"30","author":"C Charpentier","year":"1999","unstructured":"Charpentier C, Audibert G, Guillemin F, Civit T, Ducrocq X, Bracard S, et al. Multivariate analysis of predictors of cerebral vasospasm occurrence after aneurysmal subarachnoid hemorrhage. Stroke. 1999;30(7):1402\u20138. https:\/\/doi.org\/10.1161\/01.str.30.7.1402.","journal-title":"Stroke"},{"issue":"2","key":"1105_CR19","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.jneumeth.2007.08.004","volume":"167","author":"T Sugawara","year":"2008","unstructured":"Sugawara T, Ayer R, Jadhav V, Zhang JH. A new grading system evaluating bleeding scale in filament perforation subarachnoid hemorrhage rat model. J Neurosci Methods. 2008;167(2):327\u201334. https:\/\/doi.org\/10.1016\/j.jneumeth.2007.08.004.","journal-title":"J Neurosci Methods"},{"issue":"4","key":"1105_CR20","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1007\/s10571-019-00760-x","volume":"40","author":"Y Li","year":"2020","unstructured":"Li Y, Wu P, Dai J, Zhang T, Bihl J, Wang C, et al. Inhibition of mTOR alleviates early brain injury after subarachnoid hemorrhage via relieving excessive mitochondrial fission. Cell Mol Neurobiol. 2020;40(4):629\u201342. https:\/\/doi.org\/10.1007\/s10571-019-00760-x.","journal-title":"Cell Mol Neurobiol"},{"issue":"3","key":"1105_CR21","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1179\/016164107X229920","volume":"30","author":"D Zhou","year":"2008","unstructured":"Zhou D, Matchett GA, Jadhav V, Dach N, Zhang JH. The effect of 2-methoxyestradiol, a HIF-1 alpha inhibitor, in global cerebral ischemia in rats. Neurol Res. 2008;30(3):268\u201371. https:\/\/doi.org\/10.1179\/016164107X229920.","journal-title":"Neurol Res"},{"key":"1105_CR22","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.neuroscience.2019.06.025","volume":"415","author":"E Nomura","year":"2019","unstructured":"Nomura E, Ohta Y, Tadokoro K, Shang J, Feng T, Liu X, et al. Imaging hypoxic stress and the treatment of amyotrophic lateral sclerosis with dimethyloxalylglycine in a mice model. Neuroscience. 2019;415:31\u201343. https:\/\/doi.org\/10.1016\/j.neuroscience.2019.06.025.","journal-title":"Neuroscience"},{"key":"1105_CR23","doi-asserted-by":"publisher","first-page":"639049","DOI":"10.3389\/fimmu.2021.639049","volume":"12","author":"J Wang","year":"2021","unstructured":"Wang J, Yang C, Hou X, Xu J, Yun Y, Qin L, et al. Rapamycin modulates the proinflammatory memory-like response of microglia induced by BAFF. Front Immunol. 2021;12:639049. https:\/\/doi.org\/10.3389\/fimmu.2021.639049.","journal-title":"Front Immunol"},{"issue":"24","key":"1105_CR24","doi-asserted-by":"publisher","first-page":"3394","DOI":"10.1089\/neu.2018.6364","volume":"36","author":"Y Li","year":"2019","unstructured":"Li Y, Han W, Wu Y, Zhou K, Zheng Z, Wang H, et al. Stabilization of hypoxia inducible factor-1alpha by dimethyloxalylglycine promotes recovery from acute spinal cord injury by inhibiting neural apoptosis and enhancing axon regeneration. J Neurotrauma. 2019;36(24):3394\u2013409. https:\/\/doi.org\/10.1089\/neu.2018.6364.","journal-title":"J Neurotrauma"},{"issue":"1","key":"1105_CR25","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1186\/s12974-020-01830-4","volume":"17","author":"Y Peng","year":"2020","unstructured":"Peng Y, Zhuang J, Ying G, Zeng H, Zhou H, Cao Y, et al. Stimulator of IFN genes mediates neuroinflammatory injury by suppressing AMPK signal in experimental subarachnoid hemorrhage. J Neuroinflammation. 2020;17(1):165. https:\/\/doi.org\/10.1186\/s12974-020-01830-4.","journal-title":"J Neuroinflammation"},{"issue":"2","key":"1105_CR26","doi-asserted-by":"publisher","first-page":"1727","DOI":"10.1096\/fj.201800227RR","volume":"33","author":"T Li","year":"2019","unstructured":"Li T, Xu W, Gao L, Guan G, Zhang Z, He P, et al. Mesencephalic astrocyte-derived neurotrophic factor affords neuroprotection to early brain injury induced by subarachnoid hemorrhage via activating Akt-dependent prosurvival pathway and defending blood-brain barrier integrity. FASEB J. 2019;33(2):1727\u201341. https:\/\/doi.org\/10.1096\/fj.201800227RR.","journal-title":"FASEB J"},{"issue":"8","key":"1105_CR27","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1038\/s41419-019-1777-9","volume":"10","author":"P Xu","year":"2019","unstructured":"Xu P, Zhang X, Liu Q, Xie Y, Shi X, Chen J, et al. Microglial TREM-1 receptor mediates neuroinflammatory injury via interaction with SYK in experimental ischemic stroke. Cell Death Dis. 2019;10(8):555. https:\/\/doi.org\/10.1038\/s41419-019-1777-9.","journal-title":"Cell Death Dis"},{"key":"1105_CR28","doi-asserted-by":"publisher","first-page":"210","DOI":"10.3389\/fncel.2020.00210","volume":"14","author":"H Duan","year":"2020","unstructured":"Duan H, Li L, Shen S, Ma Y, Yin X, Liu Z, et al. Hydrogen sulfide reduces cognitive impairment in rats after subarachnoid hemorrhage by ameliorating neuroinflammation mediated by the TLR4\/NF-kappaB pathway in microglia. Front Cell Neurosci. 2020;14:210. https:\/\/doi.org\/10.3389\/fncel.2020.00210.","journal-title":"Front Cell Neurosci"},{"issue":"2","key":"1105_CR29","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/j.yexcr.2017.11.002","volume":"361","author":"S Wei","year":"2017","unstructured":"Wei S, Luo C, Yu S, Gao J, Liu C, Wei Z, et al. Erythropoietin ameliorates early brain injury after subarachnoid haemorrhage by modulating microglia polarization via the EPOR\/JAK2-STAT3 pathway. Exp Cell Res. 2017;361(2):342\u201352. https:\/\/doi.org\/10.1016\/j.yexcr.2017.11.002.","journal-title":"Exp Cell Res"},{"key":"1105_CR30","doi-asserted-by":"publisher","unstructured":"Garcia JH, Wagner S, Liu KF, Hu XJ. Neurological deficit and extent of neuronal necrosis attributable to middle cerebral artery occlusion in rats. Statistical validation. Stroke 1995; 26(4): 627\u2013634; discussion 635.https:\/\/doi.org\/10.1161\/01.str.26.4.627.","DOI":"10.1161\/01.str.26.4.627"},{"issue":"4","key":"1105_CR31","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1007\/s12975-020-00840-x","volume":"12","author":"P Xu","year":"2021","unstructured":"Xu P, Hong Y, Xie Y, Yuan K, Li J, Sun R, et al. TREM-1 exacerbates neuroinflammatory injury via NLRP3 inflammasome-mediated pyroptosis in experimental subarachnoid hemorrhage. Transl Stroke Res. 2021;12(4):643\u201359. https:\/\/doi.org\/10.1007\/s12975-020-00840-x.","journal-title":"Transl Stroke Res"},{"key":"1105_CR32","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.neuint.2018.05.007","volume":"118","author":"M Obara-Michlewska","year":"2018","unstructured":"Obara-Michlewska M, Ding F, Popek M, Verkhratsky A, Nedergaard M, Zielinska M, et al. Interstitial ion homeostasis and acid-base balance are maintained in oedematous brain of mice with acute toxic liver failure. Neurochem Int. 2018;118:286\u201391. https:\/\/doi.org\/10.1016\/j.neuint.2018.05.007.","journal-title":"Neurochem Int"},{"key":"1105_CR33","doi-asserted-by":"publisher","first-page":"633210","DOI":"10.3389\/fonc.2021.633210","volume":"11","author":"KJ McKelvey","year":"2021","unstructured":"McKelvey KJ, Wilson EB, Short S, Melcher AA, Biggs M, Diakos CI, et al. Glycolysis and fatty acid oxidation inhibition improves survival in glioblastoma. Front Oncol. 2021;11:633210. https:\/\/doi.org\/10.3389\/fonc.2021.633210.","journal-title":"Front Oncol"},{"issue":"8","key":"1105_CR34","doi-asserted-by":"publisher","first-page":"e0201891","DOI":"10.1371\/journal.pone.0201891","volume":"13","author":"M Morishima","year":"2018","unstructured":"Morishima M, Horikawa K, Funaki M. Cardiomyocytes cultured on mechanically compliant substrates, but not on conventional culture devices, exhibit prominent mitochondrial dysfunction due to reactive oxygen species and insulin resistance under high glucose. PLoS ONE. 2018;13(8):e0201891. https:\/\/doi.org\/10.1371\/journal.pone.0201891.","journal-title":"PLoS ONE"},{"issue":"7432","key":"1105_CR35","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1038\/nature11862","volume":"493","author":"LA O\u2019Neill","year":"2013","unstructured":"O\u2019Neill LA, Hardie DG. Metabolism of inflammation limited by AMPK and pseudo-starvation. Nature. 2013;493(7432):346\u201355. https:\/\/doi.org\/10.1038\/nature11862.","journal-title":"Nature"},{"issue":"1","key":"1105_CR36","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1186\/s12974-021-02318-5","volume":"18","author":"G Luo","year":"2021","unstructured":"Luo G, Wang X, Cui Y, Cao Y, Zhao Z, Zhang J. Metabolic reprogramming mediates hippocampal microglial M1 polarization in response to surgical trauma causing perioperative neurocognitive disorders. J Neuroinflammation. 2021;18(1):267. https:\/\/doi.org\/10.1186\/s12974-021-02318-5.","journal-title":"J Neuroinflammation"},{"issue":"1","key":"1105_CR37","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/s13045-019-0754-1","volume":"12","author":"H Hua","year":"2019","unstructured":"Hua H, Kong Q, Zhang H, Wang J, Luo T, Jiang Y. Targeting mTOR for cancer therapy. J Hematol Oncol. 2019;12(1):71. https:\/\/doi.org\/10.1186\/s13045-019-0754-1.","journal-title":"J Hematol Oncol"},{"issue":"5","key":"1105_CR38","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1002\/glia.23760","volume":"68","author":"Y Hu","year":"2020","unstructured":"Hu Y, Mai W, Chen L, Cao K, Zhang B, Zhang Z, et al. mTOR-mediated metabolic reprogramming shapes distinct microglia functions in response to lipopolysaccharide and ATP. Glia. 2020;68(5):1031\u201345. https:\/\/doi.org\/10.1002\/glia.23760.","journal-title":"Glia"},{"issue":"18","key":"1105_CR39","doi-asserted-by":"publisher","first-page":"1578","DOI":"10.1097\/WNR.0000000000001156","volume":"29","author":"W Huang","year":"2018","unstructured":"Huang W, Ding X, Ye H, Wang J, Shao J, Huang T. Hypoxia enhances the migration and invasion of human glioblastoma U87 cells through PI3K\/Akt\/mTOR\/HIF-1alpha pathway. NeuroReport. 2018;29(18):1578\u201385. https:\/\/doi.org\/10.1097\/WNR.0000000000001156.","journal-title":"NeuroReport"},{"issue":"6","key":"1105_CR40","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1007\/s10571-016-0444-2","volume":"37","author":"M Xia","year":"2017","unstructured":"Xia M, Ding Q, Zhang Z, Feng Q. Remote limb ischemic preconditioning protects rats against cerebral ischemia via HIF-1alpha\/AMPK\/HSP70 pathway. Cell Mol Neurobiol. 2017;37(6):1105\u201314. https:\/\/doi.org\/10.1007\/s10571-016-0444-2.","journal-title":"Cell Mol Neurobiol"},{"issue":"28","key":"1105_CR41","doi-asserted-by":"publisher","first-page":"20534","DOI":"10.1074\/jbc.M611782200","volume":"282","author":"SC Land","year":"2007","unstructured":"Land SC, Tee AR. Hypoxia-inducible factor 1alpha is regulated by the mammalian target of rapamycin (mTOR) via an mTOR signaling motif. J Biol Chem. 2007;282(28):20534\u201343. https:\/\/doi.org\/10.1074\/jbc.M611782200.","journal-title":"J Biol Chem"},{"issue":"9","key":"1105_CR42","doi-asserted-by":"publisher","first-page":"1895","DOI":"10.1016\/j.cellsig.2013.05.018","volume":"25","author":"MR Pawlus","year":"2013","unstructured":"Pawlus MR, Hu CJ. Enhanceosomes as integrators of hypoxia inducible factor (HIF) and other transcription factors in the hypoxic transcriptional response. Cell Signal. 2013;25(9):1895\u2013903. https:\/\/doi.org\/10.1016\/j.cellsig.2013.05.018.","journal-title":"Cell Signal"},{"key":"1105_CR43","doi-asserted-by":"publisher","first-page":"714556","DOI":"10.3389\/fphar.2021.714556","volume":"12","author":"M Fu","year":"2021","unstructured":"Fu M, Zhu Y, Zhang J, Wu W, Sun Y, Zhang X, et al. MicroRNA-221-3p suppresses the microglia activation and seizures by inhibiting of HIF-1alpha in valproic acid-resistant epilepsy. Front Pharmacol. 2021;12:714556. https:\/\/doi.org\/10.3389\/fphar.2021.714556.","journal-title":"Front Pharmacol"}],"container-title":["Translational Stroke Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12975-022-01105-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12975-022-01105-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12975-022-01105-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T08:18:40Z","timestamp":1705565920000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12975-022-01105-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,17]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["1105"],"URL":"https:\/\/doi.org\/10.1007\/s12975-022-01105-5","relation":{},"ISSN":["1868-4483","1868-601X"],"issn-type":[{"value":"1868-4483","type":"print"},{"value":"1868-601X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,17]]},"assertion":[{"value":"15 April 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 October 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 November 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 November 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was conducted in accordance with the ARRIVE guidelines and approved by the Animal and Ethics Review Committee of the Second Hospital Affiliated to Shanxi Medical University of China. All experimental procedures were conducted according to the ARRIVE guidelines. The protocols for the animal experiments were performed according to the Animal and Ethics Review Committee of our institution.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no conflicts of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}