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To ensure animal welfare,\u00a0experiments using animals abided by the ARRIVE Guidelines, the\u00a03R\u2019s concept, and the National Institutes of Health (NIH) Guide for the Care and Use of Laboratory Animals.We declare that this work has not been published elsewhere, nor is it being considered for publication by another publisher.We declare that all authors have reviewed and approved this manuscript for publication.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}