{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T23:52:53Z","timestamp":1779148373940,"version":"3.51.4"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T00:00:00Z","timestamp":1680566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T00:00:00Z","timestamp":1680566400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Transl. Stroke Res."],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1007\/s12975-023-01150-8","type":"journal-article","created":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T22:02:26Z","timestamp":1680645746000},"page":"495-497","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Stem Cell Therapy for Ischemic Brain Injury: Early Intranasal Delivery after Cardiac Arrest"],"prefix":"10.1007","volume":"15","author":[{"given":"Xiao","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofeng","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,4,4]]},"reference":[{"issue":"12","key":"1150_CR1","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1007\/s00134-021-06548-2","volume":"47","author":"C Sandroni","year":"2021","unstructured":"Sandroni C, Cronberg T, Sekhon M. Brain injury after cardiac arrest: pathophysiology, treatment, and prognosis. Intensive Care Med. 2021;47(12):1393\u2013414.","journal-title":"Intensive Care Med"},{"key":"1150_CR2","doi-asserted-by":"publisher","unstructured":"Wang Z, Zhang S, Du J, Lachance BB, Chen S, Polster BM, et al. Neuroprotection of NSC therapy is superior to glibenclamide in cardiac arrest-induced brain injury via neuroinflammation regulation. Transl Stroke Res. 2022. https:\/\/doi.org\/10.1007\/s12975-022-01047-y.","DOI":"10.1007\/s12975-022-01047-y"},{"issue":"3","key":"1150_CR3","doi-asserted-by":"publisher","first-page":"286","DOI":"10.5853\/jos.2019.03048","volume":"22","author":"S Zhang","year":"2020","unstructured":"Zhang S, et al. Optimizing stem cell therapy after ischemic brain injury. J Stroke. 2020;22(3):286.","journal-title":"J Stroke"},{"issue":"3","key":"1150_CR4","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1016\/j.neuroscience.2008.01.013","volume":"152","author":"R Thorne","year":"2008","unstructured":"Thorne R, et al. Delivery of interferon-\u03b2 to the monkey nervous system following intranasal administration. Neuroscience. 2008;152(3):785\u201397.","journal-title":"Neuroscience"},{"key":"1150_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11095-019-2613-8","volume":"36","author":"S Iwasaki","year":"2019","unstructured":"Iwasaki S, et al. Direct drug delivery of low-permeable compounds to the central nervous system via intranasal administration in rats and monkeys. Pharm Res. 2019;36:1\u201314.","journal-title":"Pharm Res"},{"issue":"3","key":"1150_CR6","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.neurobiolaging.2005.03.016","volume":"27","author":"M Reger","year":"2006","unstructured":"Reger M, et al. Effects of intranasal insulin on cognition in memory-impaired older adults: modulation by APOE genotype. Neurobiol Aging. 2006;27(3):451\u20138.","journal-title":"Neurobiol Aging"},{"issue":"6","key":"1150_CR7","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1212\/01.WNL.0000265401.62434.36","volume":"70","author":"MA Reger","year":"2008","unstructured":"Reger MA, et al. Intranasal insulin improves cognition and modulates \u03b2-amyloid in early AD. Neurology. 2008;70(6):440\u20138.","journal-title":"Neurology"},{"issue":"11","key":"1150_CR8","doi-asserted-by":"publisher","first-page":"1538","DOI":"10.1080\/02699052.2017.1376760","volume":"31","author":"A Chiaretti","year":"2017","unstructured":"Chiaretti A, et al. Intranasal nerve growth factor administration improves cerebral functions in a child with severe traumatic brain injury: a case report. Brain Inj. 2017;31(11):1538\u201347.","journal-title":"Brain Inj"},{"key":"1150_CR9","doi-asserted-by":"publisher","first-page":"2083","DOI":"10.1007\/s00381-020-04590-x","volume":"36","author":"A Chiaretti","year":"2020","unstructured":"Chiaretti A, et al. Intranasal nerve growth factor administration improves neurological outcome after GBS meningitis. Childs Nerv Syst. 2020;36:2083\u20138.","journal-title":"Childs Nerv Syst"},{"issue":"6","key":"1150_CR10","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/j.jcyt.2020.10.005","volume":"23","author":"NJ Robertson","year":"2021","unstructured":"Robertson NJ, et al. Human umbilical cord mesenchymal stromal cells as an adjunct therapy with therapeutic hypothermia in a piglet model of perinatal asphyxia. Cytotherapy. 2021;23(6):521\u201335.","journal-title":"Cytotherapy"},{"issue":"6","key":"1150_CR11","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1016\/S1474-4422(22)00117-X","volume":"21","author":"LM Baak","year":"2022","unstructured":"Baak LM, et al. Feasibility and safety of intranasally administered mesenchymal stromal cells after perinatal arterial ischaemic stroke in the Netherlands (PASSIoN): a first-in-human, open-label intervention study. Lancet Neurol. 2022;21(6):528\u201336.","journal-title":"Lancet Neurol"},{"issue":"3","key":"1150_CR12","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1007\/s12015-020-10067-w","volume":"17","author":"Z Wang","year":"2021","unstructured":"Wang Z, et al. Intracerebroventricular administration of hNSCs improves neurological recovery after cardiac arrest in rats. Stem Cell Rev Rep. 2021;17(3):923\u201337.","journal-title":"Stem Cell Rev Rep"},{"issue":"9","key":"1150_CR13","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1089\/scd.2019.0190","volume":"29","author":"P Meyer","year":"2020","unstructured":"Meyer P, et al. Grafted neural progenitor cells persist in the injured site and differentiate neuronally in a rodent model of cardiac arrest-induced global brain ischemia. Stem Cells Dev. 2020;29(9):574\u201385.","journal-title":"Stem Cells Dev"},{"issue":"5","key":"1150_CR14","doi-asserted-by":"publisher","first-page":"e2774","DOI":"10.1038\/cddis.2017.184","volume":"8","author":"L Zhou","year":"2017","unstructured":"Zhou L, et al. Enhanced neuroprotective efficacy of bone marrow mesenchymal stem cells co-overexpressing BDNF and VEGF in a rat model of cardiac arrest-induced global cerebral ischemia. Cell Death Dis. 2017;8(5):e2774.","journal-title":"Cell Death Dis"}],"container-title":["Translational Stroke Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12975-023-01150-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12975-023-01150-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12975-023-01150-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T08:32:17Z","timestamp":1716193937000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12975-023-01150-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,4]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["1150"],"URL":"https:\/\/doi.org\/10.1007\/s12975-023-01150-8","relation":{},"ISSN":["1868-4483","1868-601X"],"issn-type":[{"value":"1868-4483","type":"print"},{"value":"1868-601X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,4]]},"assertion":[{"value":"20 February 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 March 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 March 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 April 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors have approved and given the content for the publication.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}