{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T05:09:58Z","timestamp":1790226598142,"version":"4.1.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T00:00:00Z","timestamp":1686700800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T00:00:00Z","timestamp":1686700800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Transl. Stroke Res."],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1007\/s12975-023-01167-z","type":"journal-article","created":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T06:02:07Z","timestamp":1686722527000},"page":"795-804","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Risk Factors for Preoperative Cerebral Infarction in Infants with Moyamoya Disease"],"prefix":"10.1007","volume":"15","author":[{"given":"Qingbao","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songtao","family":"Pei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian-Nan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaopeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangbin","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengxing","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rimiao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minjie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heguan","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feiyan","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyang","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7210-056X","authenticated-orcid":false,"given":"Lian","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,6,14]]},"reference":[{"key":"1167_CR1","first-page":"104","volume":"14","author":"J Suzuki","year":"1983","unstructured":"Suzuki J, Kodama NJS. Moyamoya disease--a review. Am Heart Assoc. 1983;14:104\u20139.","journal-title":"Am Heart Assoc"},{"issue":"8","key":"1167_CR2","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1038\/ejhg.2017.92","volume":"25","author":"S Guey","year":"2017","unstructured":"Guey S, et al. Rare RNF213 variants in the C-terminal region encompassing the RING-finger domain are associated with moyamoya angiopathy in Caucasians. Eur J Hum Genet. 2017;25(8):995\u20131003.","journal-title":"Eur J Hum Genet"},{"issue":"10","key":"1167_CR3","doi-asserted-by":"publisher","first-page":"361","DOI":"10.2176\/nmc.ra.2019-0059","volume":"59","author":"T Mikami","year":"2019","unstructured":"Mikami T, et al. Influence of inflammatory disease on the pathophysiology of moyamoya disease and quasi-moyamoya disease. Neurol Med Chir (Tokyo). 2019;59(10):361\u201370.","journal-title":"Neurol Med Chir (Tokyo)"},{"key":"1167_CR4","doi-asserted-by":"publisher","first-page":"922482","DOI":"10.3389\/fnins.2022.922482","volume":"16","author":"K Zhang","year":"2022","unstructured":"Zhang K, et al. Angiographic characteristics of cerebral perfusion and hemodynamics of the bridging artery after surgical treatment of unilateral moyamoya disease. Front Neurosci. 2022;16:922482.","journal-title":"Front Neurosci"},{"issue":"Suppl 2","key":"1167_CR5","doi-asserted-by":"publisher","first-page":"S11","DOI":"10.1016\/S0303-8467(97)00033-4","volume":"99","author":"JU Choi","year":"1997","unstructured":"Choi JU, et al. Natural history of moyamoya disease: comparison of activity of daily living in surgery and non surgery groups. Clin Neurol Neurosurg. 1997;99(Suppl 2):S11\u20138.","journal-title":"Clin Neurol Neurosurg"},{"issue":"2 Suppl Pediatr","key":"1167_CR6","first-page":"142","volume":"100","author":"RM Scott","year":"2004","unstructured":"Scott RM, et al. Long-term outcome in children with moyamoya syndrome after cranial revascularization by pial synangiosis. J Neurosurg. 2004;100(2 Suppl Pediatrics):142\u20139.","journal-title":"J Neurosurg"},{"issue":"20","key":"1167_CR7","doi-asserted-by":"publisher","first-page":"2170","DOI":"10.1161\/CIRCULATIONAHA.105.583690","volume":"114","author":"V Ganesan","year":"2006","unstructured":"Ganesan V, et al. Clinical and radiological recurrence after childhood arterial ischemic stroke. Circulation. 2006;114(20):2170\u20137.","journal-title":"Circulation"},{"issue":"7","key":"1167_CR8","doi-asserted-by":"publisher","first-page":"2302","DOI":"10.1161\/STROKEAHA.120.032699","volume":"52","author":"T Hayashi","year":"2021","unstructured":"Hayashi T, et al. Preoperative risks of cerebral infarction in pediatric moyamoya disease. Stroke. 2021;52(7):2302\u201310.","journal-title":"Stroke"},{"issue":"2","key":"1167_CR9","doi-asserted-by":"publisher","first-page":"400","DOI":"10.3171\/2014.10.JNS14231","volume":"122","author":"T Funaki","year":"2015","unstructured":"Funaki T, et al. Unstable moyamoya disease: clinical features and impact on perioperative ischemic complications. J Neurosurg. 2015;122(2):400\u20137.","journal-title":"J Neurosurg"},{"issue":"7","key":"1167_CR10","doi-asserted-by":"publisher","first-page":"107125","DOI":"10.1016\/j.jstrokecerebrovasdis.2023.107125","volume":"32","author":"Y Wei","year":"2023","unstructured":"Wei Y, et al. Fetal posterior cerebral artery in pediatric and adult moyamoya disease: a single-center experience of 480 patients. J Stroke Cerebrovasc Dis. 2023;32(7):107125.","journal-title":"J Stroke Cerebrovasc Dis"},{"issue":"11","key":"1167_CR11","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1212\/WNL.0b013e318249f71f","volume":"78","author":"S Miyatake","year":"2012","unstructured":"Miyatake S, et al. Homozygous c.14576G>A variant of RNF213 predicts early-onset and severe form of moyamoya disease. Neurology. 2012;78(11):803\u201310.","journal-title":"Neurology"},{"issue":"10","key":"1167_CR12","first-page":"e10994","volume":"12","author":"JA Berry","year":"2020","unstructured":"Berry JA, et al. Moyamoya: an update and review. Cureus. 2020;12(10):e10994.","journal-title":"Cureus"},{"issue":"1","key":"1167_CR13","doi-asserted-by":"publisher","first-page":"73","DOI":"10.3171\/2010.4.PEDS09478","volume":"6","author":"T Hayashi","year":"2010","unstructured":"Hayashi T, et al. Postoperative neurological deterioration in pediatric moyamoya disease: watershed shift and hyperperfusion. J Neurosurg Pediatr. 2010;6(1):73\u201381.","journal-title":"J Neurosurg Pediatr"},{"issue":"4","key":"1167_CR14","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1227\/01.NEU.0000114140.41509.14","volume":"54","author":"SK Kim","year":"2004","unstructured":"Kim SK, et al. Moyamoya disease among young patients: its aggressive clinical course and the role of active surgical treatment. Neurosurgery. 2004;54(4):840\u20134.","journal-title":"Neurosurgery"},{"issue":"1","key":"1167_CR15","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1002\/ana.21981","volume":"68","author":"SK Kim","year":"2010","unstructured":"Kim SK, et al. Pediatric moyamoya disease: an analysis of 410 consecutive cases. Ann Neurol. 2010;68(1):92\u2013101.","journal-title":"Ann Neurol"},{"issue":"3","key":"1167_CR16","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1227\/00006123-199209000-00003","volume":"31","author":"T Matsushima","year":"1992","unstructured":"Matsushima T, et al. Surgical treatment of moyamoya disease in pediatric patients--comparison between the results of indirect and direct revascularization procedures. Neurosurgery. 1992;31(3):401\u20135.","journal-title":"Neurosurgery"},{"issue":"2","key":"1167_CR17","doi-asserted-by":"publisher","first-page":"E16","DOI":"10.3171\/FOC\/2008\/24\/2\/E16","volume":"24","author":"A Veeravagu","year":"2008","unstructured":"Veeravagu A, et al. Moyamoya disease in pediatric patients: outcomes of neurosurgical interventions. Neurosurg Focus. 2008;24(2):E16.","journal-title":"Neurosurg Focus"},{"issue":"5","key":"1167_CR18","doi-asserted-by":"publisher","first-page":"927","DOI":"10.3171\/2009.4.JNS081649","volume":"111","author":"R Guzman","year":"2009","unstructured":"Guzman R, et al. Clinical outcome after 450 revascularization procedures for moyamoya disease. J Neurosurg. 2009;111(5):927\u201335.","journal-title":"J Neurosurg"},{"issue":"5","key":"1167_CR19","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1007\/s00381-004-0924-4","volume":"20","author":"S Kuroda","year":"2004","unstructured":"Kuroda S, et al. Determinants of intellectual outcome after surgical revascularization in pediatric moyamoya disease: a multivariate analysis. Childs Nerv Syst. 2004;20(5):302\u20138.","journal-title":"Childs Nerv Syst"},{"key":"1167_CR20","doi-asserted-by":"publisher","first-page":"e158","DOI":"10.1016\/j.wneu.2019.12.072","volume":"136","author":"JW Choi","year":"2020","unstructured":"Choi JW, et al. Postoperative symptomatic cerebral infarction in pediatric moyamoya disease: risk factors and clinical outcome. World Neurosurg. 2020;136:e158\u201364.","journal-title":"World Neurosurg"},{"issue":"5 Suppl","key":"1167_CR21","first-page":"433","volume":"103","author":"SH Kim","year":"2005","unstructured":"Kim SH, et al. Risk factors for postoperative ischemic complications in patients with moyamoya disease. J Neurosurg. 2005;103(5 Suppl):433\u20138.","journal-title":"J Neurosurg"},{"issue":"4","key":"1167_CR22","doi-asserted-by":"publisher","first-page":"165","DOI":"10.2176\/jns-nmc.2021-0382","volume":"62","author":"M Fujimura","year":"2022","unstructured":"Fujimura M, et al. 2021 Japanese guidelines for the management of moyamoya disease: guidelines from the Research Committee on Moyamoya Disease and Japan Stroke Society. Neurol Med Chir (Tokyo). 2022;62(4):165\u201370.","journal-title":"Neurol Med Chir (Tokyo)"},{"issue":"12","key":"1167_CR23","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1056\/NEJMra0804622","volume":"360","author":"RM Scott","year":"2009","unstructured":"Scott RM, Smith ER. Moyamoya disease and moyamoya syndrome. N Engl J Med. 2009;360(12):1226\u201337.","journal-title":"N Engl J Med"},{"issue":"4","key":"1167_CR24","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/S0090-3019(81)80017-1","volume":"15","author":"Y Matsushima","year":"1981","unstructured":"Matsushima Y, et al. A new surgical treatment of moyamoya disease in children: a preliminary report. Surg Neurol. 1981;15(4):313\u201320.","journal-title":"Surg Neurol"},{"issue":"5","key":"1167_CR25","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1159\/000087935","volume":"20","author":"K Houkin","year":"2005","unstructured":"Houkin K, et al. Novel magnetic resonance angiography stage grading for moyamoya disease. Cerebrovasc Dis. 2005;20(5):347\u201354.","journal-title":"Cerebrovasc Dis"},{"issue":"10","key":"1167_CR26","first-page":"734","volume":"20","author":"K Houkin","year":"2004","unstructured":"Houkin K, et al. How does angiogenesis develop in pediatric moyamoya disease after surgery? A prospective study with MR angiography. Childs Nerv Syst. 2004;20(10):734\u201341.","journal-title":"Childs Nerv Syst"},{"issue":"5","key":"1167_CR27","doi-asserted-by":"publisher","first-page":"e694","DOI":"10.1542\/peds.2005-0568","volume":"116","author":"A Jea","year":"2005","unstructured":"Jea A, et al. Moyamoya syndrome associated with Down syndrome: outcome after surgical revascularization. Pediatrics. 2005;116(5):e694\u2013701.","journal-title":"Pediatrics"},{"issue":"2","key":"1167_CR28","doi-asserted-by":"publisher","first-page":"173","DOI":"10.3171\/2018.2.PEDS17591","volume":"22","author":"Y Zhang","year":"2018","unstructured":"Zhang Y, et al. Encephaloduroarteriosynangiosis for pediatric moyamoya disease: long-term follow-up of 100 cases at a single center. J Neurosurg Pediatr. 2018;22(2):173\u201380.","journal-title":"J Neurosurg Pediatr"},{"issue":"3","key":"1167_CR29","doi-asserted-by":"publisher","first-page":"e51","DOI":"10.1161\/STR.0000000000000183","volume":"50","author":"DM Ferriero","year":"2019","unstructured":"Ferriero DM, et al. Management of stroke in neonates and children: a scientific statement from the American Heart Association\/American Stroke Association. Stroke. 2019;50(3):e51\u201396.","journal-title":"Stroke"},{"issue":"1","key":"1167_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3171\/2016.7.PEDS16218","volume":"19","author":"HG Kim","year":"2017","unstructured":"Kim HG, Lee SK, Lee JD. Characteristics of infarction after encephaloduroarteriosynangiosis in young patients with moyamoya disease. J Neurosurg Pediatr. 2017;19(1):1\u20137.","journal-title":"J Neurosurg Pediatr"},{"issue":"3","key":"1167_CR31","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1161\/01.STR.16.3.397","volume":"16","author":"EC\/IC Bypass Study Group","year":"1985","unstructured":"EC\/IC Bypass Study Group. The International Cooperative Study of Extracranial\/Intracranial Arterial Anastomosis (EC\/IC Bypass Study): methodology and entry characteristics. The EC\/IC Bypass Study group. Stroke. 1985;16(3):397\u2013406.","journal-title":"Stroke"},{"issue":"11","key":"1167_CR32","doi-asserted-by":"publisher","first-page":"3177","DOI":"10.1161\/STROKEAHA.119.025609","volume":"50","author":"EJ Ha","year":"2019","unstructured":"Ha EJ, et al. Long-term outcomes of indirect bypass for 629 children with moyamoya disease: longitudinal and cross-sectional analysis. Stroke. 2019;50(11):3177\u201383.","journal-title":"Stroke"},{"issue":"8","key":"1167_CR33","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/S1474-4422(22)00165-X","volume":"21","author":"M Ihara","year":"2022","unstructured":"Ihara M, et al. Moyamoya disease: diagnosis and interventions. Lancet Neurol. 2022;21(8):747\u201358.","journal-title":"Lancet Neurol"},{"issue":"Suppl 2","key":"1167_CR34","doi-asserted-by":"publisher","first-page":"S238","DOI":"10.1016\/S0303-8467(97)00082-6","volume":"99","author":"M Fukui","year":"1997","unstructured":"Fukui M. Guidelines for the diagnosis and treatment of spontaneous occlusion of the circle of Willis ('moyamoya' disease). Research Committee on Spontaneous Occlusion of the Circle of Willis (Moyamoya Disease) of the Ministry of Health and Welfare, Japan. Clin Neurol Neurosurg. 1997;99(Suppl 2):S238\u201340.","journal-title":"Clin Neurol Neurosurg"},{"issue":"3","key":"1167_CR35","doi-asserted-by":"publisher","first-page":"195","DOI":"10.2176\/nmc.51.195","volume":"51","author":"Q Jin","year":"2011","unstructured":"Jin Q, et al. Assessment of moyamoya disease with 3.0-T magnetic resonance angiography and magnetic resonance imaging versus conventional angiography. Neurol Med Chir (Tokyo). 2011;51(3):195\u2013200.","journal-title":"Neurol Med Chir (Tokyo)"},{"issue":"1","key":"1167_CR36","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1055\/s-2007-973747","volume":"27","author":"M Kikuchi","year":"1996","unstructured":"Kikuchi M, et al. Evaluation of surgically formed collateral circulation in moyamoya disease with 3D-CT angiography: comparison with MR angiography and X-ray angiography. Neuropediatrics. 1996;27(1):45\u20139.","journal-title":"Neuropediatrics"},{"issue":"2","key":"1167_CR37","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1111\/jon.12489","volume":"28","author":"M Miura","year":"2018","unstructured":"Miura M, et al. Decreased signal intensity ratio on MRA reflects misery perfusion on SPECT in patients with intracranial stenosis. J Neuroimaging. 2018;28(2):206\u201311.","journal-title":"J Neuroimaging"},{"issue":"1","key":"1167_CR38","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1111\/jon.12101","volume":"25","author":"DS Liebeskind","year":"2015","unstructured":"Liebeskind DS, et al. Noninvasive fractional flow on MRA predicts stroke risk of intracranial stenosis. J Neuroimaging. 2015;25(1):87\u201391.","journal-title":"J Neuroimaging"},{"issue":"7","key":"1167_CR39","doi-asserted-by":"publisher","first-page":"e22542","DOI":"10.1371\/journal.pone.0022542","volume":"6","author":"W Liu","year":"2011","unstructured":"Liu W, et al. Identification of RNF213 as a susceptibility gene for moyamoya disease and its possible role in vascular development. PLoS One. 2011;6(7):e22542.","journal-title":"PLoS One"},{"issue":"8","key":"1167_CR40","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1136\/jnnp.2007.130666","volume":"79","author":"T Baba","year":"2008","unstructured":"Baba T, Houkin K, Kuroda S. Novel epidemiological features of moyamoya disease. J Neurol Neurosurg Psychiatry. 2008;79(8):900\u20134.","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"3","key":"1167_CR41","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1007\/s00381-005-1230-5","volume":"22","author":"R Nanba","year":"2006","unstructured":"Nanba R, et al. Clinical features of familial moyamoya disease. Childs Nerv Syst. 2006;22(3):258\u201362.","journal-title":"Childs Nerv Syst"},{"issue":"12","key":"1167_CR42","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1038\/jhg.2012.105","volume":"57","author":"S Miyatake","year":"2012","unstructured":"Miyatake S, et al. Sibling cases of moyamoya disease having homozygous and heterozygous c.14576G>A variant in RNF213 showed varying clinical course and severity. J Hum Genet. 2012;57(12):804\u20136.","journal-title":"J Hum Genet"}],"container-title":["Translational Stroke Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12975-023-01167-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12975-023-01167-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12975-023-01167-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T09:50:06Z","timestamp":1720173006000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12975-023-01167-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,14]]},"references-count":42,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["1167"],"URL":"https:\/\/doi.org\/10.1007\/s12975-023-01167-z","relation":{},"ISSN":["1868-4483","1868-601X"],"issn-type":[{"value":"1868-4483","type":"print"},{"value":"1868-601X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,14]]},"assertion":[{"value":"12 May 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 June 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 June 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 June 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Ethics Committee of the Fifth Medical Center of the PLA General Hospital and was performed in accordance with the ethical standards as laid down in the  and its later amendments.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Written informed consent was obtained by each member involved in this study from a parent or guardian of each infant.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed Consent"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}