{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T15:32:00Z","timestamp":1782401520975,"version":"3.54.5"},"reference-count":65,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T00:00:00Z","timestamp":1692748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T00:00:00Z","timestamp":1692748800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"NIH","award":["1R01 NS105675"],"award-info":[{"award-number":["1R01 NS105675"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Transl. Stroke Res."],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1007\/s12975-023-01186-w","type":"journal-article","created":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T16:02:28Z","timestamp":1692806548000},"page":"1108-1122","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Transcriptomic Comparative Study of Cranial Vasculature"],"prefix":"10.1007","volume":"15","author":[{"given":"Jianing","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jee-Yeon","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selena-Rae","family":"Tirado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence D.","family":"Dickinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aviva","family":"Abosch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Ali","family":"Aziz-Sultan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan S.","family":"Boulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel L.","family":"Barrow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Hunt","family":"Batjer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamar R.","family":"Binyamin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spiros L.","family":"Blackburn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward F.","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. Roc","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey P.","family":"Colby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Rees","family":"Cosgrove","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos A.","family":"David","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur L.","family":"Day","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca D.","family":"Folkerth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai U.","family":"Frerichs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian M.","family":"Howard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behnam R.","family":"Jahromi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Niemela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven G.","family":"Ojemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nirav J.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Mark","family":"Richardson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangen","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edison P.","family":"Valle-Giler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony C.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babu G.","family":"Welch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziv","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edie E.","family":"Zusman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott T.","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rose","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"GENIE Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,8,23]]},"reference":[{"key":"1186_CR1","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/B978-0-12-802973-2.00014-8","volume":"138","author":"ML Portegies","year":"2016","unstructured":"Portegies ML, Koudstaal PJ, Ikram MA. Cerebrovascular disease. Handb Clin Neurol. 2016;138:239\u201361. https:\/\/doi.org\/10.1016\/B978-0-12-802973-2.00014-8.","journal-title":"Handb Clin Neurol"},{"key":"1186_CR2","doi-asserted-by":"publisher","first-page":"6645","DOI":"10.1007\/s12035-019-1561-y","volume":"56","author":"JR Kane","year":"2019","unstructured":"Kane JR. The role of brain vasculature in glioblastoma. Mol Neurobiol. 2019;56:6645\u201353. https:\/\/doi.org\/10.1007\/s12035-019-1561-y.","journal-title":"Mol Neurobiol"},{"key":"1186_CR3","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1038\/s41593-018-0234-x","volume":"21","author":"MD Sweeney","year":"2018","unstructured":"Sweeney MD, Kisler K, Montagne A, Toga AW, Zlokovic BV. The role of brain vasculature in neurodegenerative disorders. Nat Neurosci. 2018;21:1318\u201331. https:\/\/doi.org\/10.1038\/s41593-018-0234-x.","journal-title":"Nat Neurosci"},{"key":"1186_CR4","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1002\/med.21817","volume":"42","author":"QZ Tuo","year":"2022","unstructured":"Tuo QZ, Zhang ST, Lei P. Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications. Med Res Rev. 2022;42:259\u2013305. https:\/\/doi.org\/10.1002\/med.21817.","journal-title":"Med Res Rev"},{"key":"1186_CR5","doi-asserted-by":"publisher","first-page":"eabi7377","DOI":"10.1126\/science.abi7377","volume":"375","author":"EA Winkler","year":"2022","unstructured":"Winkler EA, Kim CN, Ross JM, Garcia JH, Gil E, Oh I, Chen LQ, Wu D, Catapano JS, Raygor K, et al. A single-cell atlas of the normal and malformed human brain vasculature. Science. 2022;375:eabi7377. https:\/\/doi.org\/10.1126\/science.abi7377.","journal-title":"Science"},{"key":"1186_CR6","doi-asserted-by":"publisher","first-page":"3613","DOI":"10.1161\/STROKEAHA.113.002390","volume":"44","author":"N Chalouhi","year":"2013","unstructured":"Chalouhi N, Hoh BL, Hasan D. Review of cerebral aneurysm formation, growth, and rupture. Stroke. 2013;44:3613\u201322. https:\/\/doi.org\/10.1161\/STROKEAHA.113.002390.","journal-title":"Stroke"},{"key":"1186_CR7","doi-asserted-by":"publisher","unstructured":"Strange F, Gruter BE, Fandino J, Marbacher S. Preclinical intracranial aneurysm models: a systematic review. Brain Sci. 2020;10:134.\u00a0https:\/\/doi.org\/10.3390\/brainsci10030134.\u00a0","DOI":"10.3390\/brainsci10030134"},{"key":"1186_CR8","doi-asserted-by":"publisher","first-page":"991425","DOI":"10.3389\/fmolb.2022.991425","volume":"9","author":"S Li","year":"2022","unstructured":"Li S, Han Y, Zhang Q, Tang D, Li J, Weng L. Comprehensive molecular analyses of an autoimmune-related gene predictive model and immune infiltrations using machine learning methods in moyamoya disease. Front Mol Biosci. 2022;9:991425. https:\/\/doi.org\/10.3389\/fmolb.2022.991425.","journal-title":"Front Mol Biosci"},{"key":"1186_CR9","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1159\/000236911","volume":"62","author":"L Li","year":"2009","unstructured":"Li L, Yang X, Jiang F, Dusting GJ, Wu Z. Transcriptome-wide characterization of gene expression associated with unruptured intracranial aneurysms. Eur Neurol. 2009;62:330\u20137. https:\/\/doi.org\/10.1159\/000236911.","journal-title":"Eur Neurol"},{"key":"1186_CR10","doi-asserted-by":"publisher","first-page":"2239","DOI":"10.1161\/STROKEAHA.114.005851","volume":"45","author":"H Nakaoka","year":"2014","unstructured":"Nakaoka H, Tajima A, Yoneyama T, Hosomichi K, Kasuya H, Mizutani T, Inoue I. Gene expression profiling reveals distinct molecular signatures associated with the rupture of intracranial aneurysm. Stroke. 2014;45:2239\u201345. https:\/\/doi.org\/10.1161\/STROKEAHA.114.005851.","journal-title":"Stroke"},{"key":"1186_CR11","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/1755-8794-6-36","volume":"6","author":"Y Jiang","year":"2013","unstructured":"Jiang Y, Zhang M, He H, Chen J, Zeng H, Li J, Duan R. MicroRNA\/mRNA profiling and regulatory network of intracranial aneurysm. BMC Med Genomics. 2013;6:36. https:\/\/doi.org\/10.1186\/1755-8794-6-36.","journal-title":"BMC Med Genomics"},{"key":"1186_CR12","doi-asserted-by":"publisher","first-page":"10387","DOI":"10.1038\/s41598-019-46886-2","volume":"9","author":"T Aoki","year":"2019","unstructured":"Aoki T, Koseki H, Miyata H, Itoh M, Kawaji H, Takizawa K, Kawashima A, Ujiie H, Higa T, Minamimura K, et al. RNA sequencing analysis revealed the induction of CCL3 expression in human intracranial aneurysms. Sci Rep. 2019;9:10387. https:\/\/doi.org\/10.1038\/s41598-019-46886-2.","journal-title":"Sci Rep"},{"key":"1186_CR13","doi-asserted-by":"publisher","first-page":"4819","DOI":"10.12659\/MSM.917081","volume":"25","author":"Q Huang","year":"2019","unstructured":"Huang Q, Huang QY, Sun Y, Wu S. High-throughput data reveals novel circular RNAs via competitive endogenous RNA networks associated with human intracranial aneurysms. Med Sci Monit. 2019;25:4819\u201330. https:\/\/doi.org\/10.12659\/MSM.917081.","journal-title":"Med Sci Monit"},{"key":"1186_CR14","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.jocn.2017.07.016","volume":"47","author":"J Fan","year":"2018","unstructured":"Fan J, Yu L, Zhao J. Comparative transcriptome analysis reveals involvement of TLR-2 signaling in the pathogenesis of intracranial aneurysm. J Clin Neurosci. 2018;47:258\u201363. https:\/\/doi.org\/10.1016\/j.jocn.2017.07.016.","journal-title":"J Clin Neurosci"},{"key":"1186_CR15","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.3171\/2016.9.JNS16839","volume":"127","author":"H Li","year":"2017","unstructured":"Li H, Yue H, Hao Y, Li H, Wang S, Yu L, Zhang D, Cao Y, Zhao J. Expression profile of long noncoding RNAs in human cerebral aneurysms: a microarray analysis. J Neurosurg. 2017;127:1055\u201362. https:\/\/doi.org\/10.3171\/2016.9.JNS16839.","journal-title":"J Neurosurg"},{"key":"1186_CR16","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.wneu.2017.04.064","volume":"105","author":"L Yu","year":"2017","unstructured":"Yu L, Wang J, Wang S, Zhang D, Zhao Y, Wang R, Zhao J. DNA methylation regulates gene expression in intracranial aneurysms. World Neurosurg. 2017;105:28\u201336. https:\/\/doi.org\/10.1016\/j.wneu.2017.04.064.","journal-title":"World Neurosurg"},{"key":"1186_CR17","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1007\/s10143-016-0799-3","volume":"40","author":"H Li","year":"2017","unstructured":"Li H, Li H, Yue H, Wang W, Yu L, Shuo W, Cao Y, Zhao J. Comparison between smaller ruptured intracranial aneurysm and larger un-ruptured intracranial aneurysm: gene expression profile analysis. Neurosurg Rev. 2017;40:419\u201325. https:\/\/doi.org\/10.1007\/s10143-016-0799-3.","journal-title":"Neurosurg Rev"},{"key":"1186_CR18","doi-asserted-by":"publisher","first-page":"2477","DOI":"10.18632\/oncotarget.13908","volume":"8","author":"W Wang","year":"2017","unstructured":"Wang W, Li H, Yu L, Zhao Z, Wang H, Zhang D, Zhang Y, Lan Q, Wang J, Zhao J. Aberrant expression of lncRNAs and mRNAs in patients with intracranial aneurysm. Oncotarget. 2017;8:2477\u201384. https:\/\/doi.org\/10.18632\/oncotarget.13908.","journal-title":"Oncotarget"},{"key":"1186_CR19","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1016\/j.wneu.2016.10.016","volume":"97","author":"H Li","year":"2017","unstructured":"Li H, Wang W, Zhang L, Lan Q, Wang J, Cao Y, Zhao J. Identification of a long noncoding RNA-associated competing endogenous RNA network in intracranial aneurysm. World Neurosurg. 2017;97:684\u201392. https:\/\/doi.org\/10.1016\/j.wneu.2016.10.016.","journal-title":"World Neurosurg"},{"key":"1186_CR20","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.3171\/2015.11.JNS151841","volume":"125","author":"K Bekelis","year":"2016","unstructured":"Bekelis K, Kerley-Hamilton JS, Teegarden A, Tomlinson CR, Kuintzle R, Simmons N, Singer RJ, Roberts DW, Kellis M, Hendrix DA. MicroRNA and gene expression changes in unruptured human cerebral aneurysms. J Neurosurg. 2016;125:1390\u20139. https:\/\/doi.org\/10.3171\/2015.11.JNS151841.","journal-title":"J Neurosurg"},{"key":"1186_CR21","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/s12264-013-1398-8","volume":"30","author":"L Yu","year":"2014","unstructured":"Yu L, Fan J, Wang S, Zhang D, Wang R, Zhao Y, Zhao J. Gene expression profiles in intracranial aneurysms. Neurosci Bull. 2014;30:99\u2013106. https:\/\/doi.org\/10.1007\/s12264-013-1398-8.","journal-title":"Neurosci Bull"},{"key":"1186_CR22","first-page":"185","volume":"24","author":"E Marchese","year":"2010","unstructured":"Marchese E, Vignati A, Albanese A, Nucci CG, Sabatino G, Tirpakova B, Lofrese G, Zelano G, Maira G. Comparative evaluation of genome-wide gene expression profiles in ruptured and unruptured human intracranial aneurysms. J Biol Regul Homeost Agents. 2010;24:185\u201395.","journal-title":"J Biol Regul Homeost Agents"},{"key":"1186_CR23","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1161\/STROKEAHA.108.532036","volume":"40","author":"C Shi","year":"2009","unstructured":"Shi C, Awad IA, Jafari N, Lin S, Du P, Hage ZA, Shenkar R, Getch CC, Bredel M, Batjer HH, et al. Genomics of human intracranial aneurysm wall. Stroke. 2009;40:1252\u201361. https:\/\/doi.org\/10.1161\/STROKEAHA.108.532036.","journal-title":"Stroke"},{"key":"1186_CR24","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1161\/01.str.32.4.1036","volume":"32","author":"DG Peters","year":"2001","unstructured":"Peters DG, Kassam AB, Feingold E, Heidrich-O\u2019Hare E, Yonas H, Ferrell RE, Brufsky A. Molecular anatomy of an intracranial aneurysm: coordinated expression of genes involved in wound healing and tissue remodeling. Stroke. 2001;32:1036\u201342. https:\/\/doi.org\/10.1161\/01.str.32.4.1036.","journal-title":"Stroke"},{"key":"1186_CR25","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1161\/STROKEAHA.117.018152","volume":"49","author":"S Zhou","year":"2018","unstructured":"Zhou S, Dion PA, Rouleau GA. Genetics of intracranial aneurysms. Stroke. 2018;49:780\u20137. https:\/\/doi.org\/10.1161\/STROKEAHA.117.018152.","journal-title":"Stroke"},{"key":"1186_CR26","doi-asserted-by":"publisher","first-page":"179","DOI":"10.2176\/nmc.50.179","volume":"50","author":"T Masuoka","year":"2010","unstructured":"Masuoka T, Hayashi N, Hori E, Kuwayama N, Ohtani O, Endo S. Distribution of internal elastic lamina and external elastic lamina in the internal carotid artery: possible relationship with atherosclerosis. Neurol Med Chir (Tokyo). 2010;50:179\u201382. https:\/\/doi.org\/10.2176\/nmc.50.179.","journal-title":"Neurol Med Chir (Tokyo)"},{"key":"1186_CR27","doi-asserted-by":"publisher","first-page":"127","DOI":"10.4103\/0970-0358.81449","volume":"44","author":"S Reddy","year":"2011","unstructured":"Reddy S, Kumar P, Prasad K. Histomorphometric and sympathetic innervation of the human superficial temporal artery. Indian J Plast Surg. 2011;44:127\u201333. https:\/\/doi.org\/10.4103\/0970-0358.81449.","journal-title":"Indian J Plast Surg"},{"issue":"49","key":"1186_CR28","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1007\/s10396-021-01164-5","volume":"2022","author":"Y Hitomi","year":"2001","unstructured":"Hitomi Y, Masaki N, Ishinoda Y, Kagami K, Yasuda R, Toya T, Namba T, Nagatomo Y, Takase B, Adachi T. Effectiveness of pulsatility index of carotid Doppler ultrasonography to predict cardiovascular events. J Med Ultrason. 2001;2022(49):95\u2013103. https:\/\/doi.org\/10.1007\/s10396-021-01164-5.","journal-title":"J Med Ultrason"},{"key":"1186_CR29","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1016\/j.jvs.2019.10.099","volume":"72","author":"MD Kronick","year":"2020","unstructured":"Kronick MD, Chopra A, Swamy S, Brar V, Jung E, Abraham CZ, Liem TK, Landry GJ, Moneta GL. Peak systolic velocity and color aliasing are important in the development of duplex ultrasound criteria for external carotid artery stenosis. J Vasc Surg. 2020;72:951\u20137. https:\/\/doi.org\/10.1016\/j.jvs.2019.10.099.","journal-title":"J Vasc Surg"},{"key":"1186_CR30","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","volume":"29","author":"A Dobin","year":"2013","unstructured":"Dobin A, Davis CA, Schlesinger F, Drenkow J, Zaleski C, Jha S, Batut P, Chaisson M, Gingeras TR. STAR: ultrafast universal RNA-seq aligner. Bioinformatics. 2013;29:15\u201321. https:\/\/doi.org\/10.1093\/bioinformatics\/bts635.","journal-title":"Bioinformatics"},{"key":"1186_CR31","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","volume":"15","author":"MI Love","year":"2014","unstructured":"Love MI, Huber W, Anders S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 2014;15:550. https:\/\/doi.org\/10.1186\/s13059-014-0550-8.","journal-title":"Genome Biol"},{"key":"1186_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18637\/jss.v025.i01","volume":"25","author":"S L\u00ea","year":"2008","unstructured":"L\u00ea S, Josse J, Husson F. FactoMineR: An R package for multivariate analysis. J Stat Softw. 2008;25:1\u201318. https:\/\/doi.org\/10.18637\/jss.v025.i01.","journal-title":"J Stat Softw"},{"key":"1186_CR33","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1093\/bioinformatics\/btr709","volume":"28","author":"R Kolde","year":"2012","unstructured":"Kolde R, Laur S, Adler P, Vilo J. Robust rank aggregation for gene list integration and meta-analysis. Bioinformatics. 2012;28:573\u201380. https:\/\/doi.org\/10.1093\/bioinformatics\/btr709.","journal-title":"Bioinformatics"},{"key":"1186_CR34","doi-asserted-by":"publisher","first-page":"100141","DOI":"10.1016\/j.xinn.2021.100141","volume":"2","author":"T Wu","year":"2021","unstructured":"Wu T, Hu E, Xu S, Chen M, Guo P, Dai Z, Feng T, Zhou L, Tang W, Zhan L, et al. clusterProfiler 4.0: a universal enrichment tool for interpreting omics data. Innovation (Camb). 2021;2:100141. https:\/\/doi.org\/10.1016\/j.xinn.2021.100141.","journal-title":"Innovation (Camb)"},{"key":"1186_CR35","doi-asserted-by":"publisher","first-page":"146","DOI":"10.12688\/f1000research.4431.2","volume":"3","author":"G Wu","year":"2014","unstructured":"Wu G, Dawson E, Duong A, Haw R, Stein L. ReactomeFIViz: a Cytoscape app for pathway and network-based data analysis. F1000Res. 2014;3:146. https:\/\/doi.org\/10.12688\/f1000research.4431.2.","journal-title":"F1000Res"},{"key":"1186_CR36","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1093\/bioinformatics\/btp101","volume":"25","author":"G Bindea","year":"2009","unstructured":"Bindea G, Mlecnik B, Hackl H, Charoentong P, Tosolini M, Kirilovsky A, Fridman WH, Pages F, Trajanoski Z, Galon J. ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks. Bioinformatics. 2009;25:1091\u20133. https:\/\/doi.org\/10.1093\/bioinformatics\/btp101.","journal-title":"Bioinformatics"},{"key":"1186_CR37","doi-asserted-by":"publisher","first-page":"D687","DOI":"10.1093\/nar\/gkab1028","volume":"50","author":"M Gillespie","year":"2022","unstructured":"Gillespie M, Jassal B, Stephan R, Milacic M, Rothfels K, Senff-Ribeiro A, Griss J, Sevilla C, Matthews L, Gong C, et al. The reactome pathway knowledgebase 2022. Nucleic Acids Res. 2022;50:D687\u201392. https:\/\/doi.org\/10.1093\/nar\/gkab1028.","journal-title":"Nucleic Acids Res"},{"key":"1186_CR38","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1038\/s41587-019-0114-2","volume":"37","author":"AM Newman","year":"2019","unstructured":"Newman AM, Steen CB, Liu CL, Gentles AJ, Chaudhuri AA, Scherer F, Khodadoust MS, Esfahani MS, Luca BA, Steiner D, et al. Determining cell type abundance and expression from bulk tissues with digital cytometry. Nat Biotechnol. 2019;37:773\u201382. https:\/\/doi.org\/10.1038\/s41587-019-0114-2.","journal-title":"Nat Biotechnol"},{"key":"1186_CR39","doi-asserted-by":"publisher","first-page":"1657","DOI":"10.7314\/apjcp.2012.13.4.1657","volume":"13","author":"XS Yang","year":"2012","unstructured":"Yang XS, Liu SA, Liu JW, Yan Q. Fucosyltransferase IV enhances expression of MMP-12 stimulated by EGF via the ERK1\/2, p38 and NF-kappaB pathways in A431 cells. Asian Pac J Cancer Prev. 2012;13:1657\u201362. https:\/\/doi.org\/10.7314\/apjcp.2012.13.4.1657.","journal-title":"Asian Pac J Cancer Prev"},{"key":"1186_CR40","doi-asserted-by":"publisher","first-page":"10","DOI":"10.4161\/cam.4.1.9834","volume":"4","author":"C Huang","year":"2010","unstructured":"Huang C. Roles of E3 ubiquitin ligases in cell adhesion and migration. Cell Adh Migr. 2010;4:10\u20138. https:\/\/doi.org\/10.4161\/cam.4.1.9834.","journal-title":"Cell Adh Migr"},{"key":"1186_CR41","doi-asserted-by":"publisher","first-page":"5629","DOI":"10.4049\/jimmunol.160.11.5629","volume":"160","author":"M Salmi","year":"1998","unstructured":"Salmi M, Hellman J, Jalkanen S. The role of two distinct endothelial molecules, vascular adhesion protein-1 and peripheral lymph node addressin, in the binding of lymphocyte subsets to human lymph nodes. J Immunol. 1998;160:5629\u201336.","journal-title":"J Immunol"},{"key":"1186_CR42","doi-asserted-by":"publisher","first-page":"4809","DOI":"10.1073\/pnas.1504378112","volume":"112","author":"K Castillo","year":"2015","unstructured":"Castillo K, Contreras GF, Pupo A, Torres YP, Neely A, Gonzalez C, Latorre R. Molecular mechanism underlying beta1 regulation in voltage- and calcium-activated potassium (BK) channels. Proc Natl Acad Sci U S A. 2015;112:4809\u201314. https:\/\/doi.org\/10.1073\/pnas.1504378112.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1186_CR43","doi-asserted-by":"publisher","first-page":"613","DOI":"10.3390\/genes14030613","volume":"14","author":"R Morga","year":"2023","unstructured":"Morga R, Pera J. Transcriptomic studies on intracranial aneurysms. Genes. 2023;14:613.","journal-title":"Genes"},{"key":"1186_CR44","doi-asserted-by":"publisher","first-page":"4415","DOI":"10.3892\/mmr.2019.10696","volume":"20","author":"T Guo","year":"2019","unstructured":"Guo T, Hou D, Yu D. Bioinformatics analysis of gene expression profile data to screen key genes involved in intracranial aneurysms. Mol Med Rep. 2019;20:4415\u201324. https:\/\/doi.org\/10.3892\/mmr.2019.10696.","journal-title":"Mol Med Rep"},{"key":"1186_CR45","doi-asserted-by":"publisher","first-page":"3473","DOI":"10.3892\/mmr.2017.8367","volume":"17","author":"L Bo","year":"2018","unstructured":"Bo L, Wei B, Wang Z, Li C, Gao Z, Miao Z. Bioinformatic analysis of gene expression profiling of intracranial aneurysm. Mol Med Rep. 2018;17:3473\u201380. https:\/\/doi.org\/10.3892\/mmr.2017.8367.","journal-title":"Mol Med Rep"},{"key":"1186_CR46","doi-asserted-by":"publisher","first-page":"2217","DOI":"10.2147\/IJGM.S347420","volume":"15","author":"H Zhu","year":"2022","unstructured":"Zhu H, Tan J, Zhao Y, Wang Z, Wu Z, Li M. Potential role of the chemotaxis system in formation and progression of intracranial aneurysms through weighted gene co-expression network analysis. Int J Gen Med. 2022;15:2217\u201331. https:\/\/doi.org\/10.2147\/IJGM.S347420.","journal-title":"Int J Gen Med"},{"key":"1186_CR47","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1038\/s41598-021-04390-6","volume":"12","author":"Y Jiang","year":"2022","unstructured":"Jiang Y, Leng J, Lin Q, Zhou F. Epithelial-mesenchymal transition related genes in unruptured aneurysms identified through weighted gene coexpression network analysis. Sci Rep. 2022;12:225. https:\/\/doi.org\/10.1038\/s41598-021-04390-6.","journal-title":"Sci Rep"},{"key":"1186_CR48","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1038\/cgt.2015.10","volume":"22","author":"X Zheng","year":"2015","unstructured":"Zheng X, Xue C, Luo G, Hu Y, Luo W, Sun X. Identification of crucial genes in intracranial aneurysm based on weighted gene coexpression network analysis. Cancer Gene Ther. 2015;22:238\u201345. https:\/\/doi.org\/10.1038\/cgt.2015.10.","journal-title":"Cancer Gene Ther"},{"key":"1186_CR49","doi-asserted-by":"publisher","first-page":"758","DOI":"10.4238\/2014.January.31.2","volume":"13","author":"L Chen","year":"2014","unstructured":"Chen L, Fan Y, Wan J. Screening of key genes of unruptured intracranial aneurysms by using DNA microarray data analysis techniques. Genet Mol Res. 2014;13:758\u201367. https:\/\/doi.org\/10.4238\/2014.January.31.2.","journal-title":"Genet Mol Res"},{"key":"1186_CR50","doi-asserted-by":"publisher","first-page":"3263","DOI":"10.4238\/2013.September.3.2","volume":"12","author":"L Wei","year":"2013","unstructured":"Wei L, Gao YJ, Wei SP, Zhang YF, Zhang WF, Jiang JX, Sun ZY, Xu W. Transcriptome network-based method to identify genes associated with unruptured intracranial aneurysms. Genet Mol Res. 2013;12:3263\u201373. https:\/\/doi.org\/10.4238\/2013.September.3.2.","journal-title":"Genet Mol Res"},{"key":"1186_CR51","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1186\/s12859-021-04513-w","volume":"22","author":"R Sun","year":"2021","unstructured":"Sun R, Zhou Y, Cui Q. Comparative analysis of aneurysm subtypes associated genes based on protein-protein interaction network. BMC Bioinformatics. 2021;22:587. https:\/\/doi.org\/10.1186\/s12859-021-04513-w.","journal-title":"BMC Bioinformatics"},{"key":"1186_CR52","doi-asserted-by":"publisher","first-page":"2933","DOI":"10.1161\/STROKEAHA.119.024881","volume":"50","author":"MD Laarman","year":"2019","unstructured":"Laarman MD, Kleinloog R, Bakker MK, Rinkel GJE, Bakkers J, Ruigrok YM. Assessment of the most optimal control tissue for intracranial aneurysm gene expression studies. Stroke. 2019;50:2933\u20136. https:\/\/doi.org\/10.1161\/STROKEAHA.119.024881.","journal-title":"Stroke"},{"key":"1186_CR53","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1038\/nrneurol.2016.150","volume":"12","author":"N Etminan","year":"2016","unstructured":"Etminan N, Rinkel GJ. Unruptured intracranial aneurysms: development, rupture and preventive management. Nat Rev Neurol. 2016;12:699\u2013713. https:\/\/doi.org\/10.1038\/nrneurol.2016.150.","journal-title":"Nat Rev Neurol"},{"key":"1186_CR54","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/2041-2223-4-7","volume":"4","author":"SL Fordyce","year":"2013","unstructured":"Fordyce SL, Kampmann ML, van Doorn NL, Gilbert MT. Long-term RNA persistence in postmortem contexts. Investig Genet. 2013;4:7. https:\/\/doi.org\/10.1186\/2041-2223-4-7.","journal-title":"Investig Genet"},{"key":"1186_CR55","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/nrneurol.2010.178","volume":"7","author":"A Vezzani","year":"2011","unstructured":"Vezzani A, French J, Bartfai T, Baram TZ. The role of inflammation in epilepsy. Nat Rev Neurol. 2011;7:31\u201340. https:\/\/doi.org\/10.1038\/nrneurol.2010.178.","journal-title":"Nat Rev Neurol"},{"key":"1186_CR56","doi-asserted-by":"publisher","first-page":"E3","DOI":"10.3171\/2021.6.FOCUS20870","volume":"51","author":"F Kanamori","year":"2021","unstructured":"Kanamori F, Yokoyama K, Ota A, Yoshikawa K, Karnan S, Maruwaka M, Shimizu K, Ota S, Uda K, Araki Y, et al. Transcriptome-wide analysis of intracranial artery in patients with moyamoya disease showing upregulation of immune response, and downregulation of oxidative phosphorylation and DNA repair. Neurosurg Focus. 2021;51:E3. https:\/\/doi.org\/10.3171\/2021.6.FOCUS20870.","journal-title":"Neurosurg Focus"},{"key":"1186_CR57","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1038\/s41588-020-00725-7","volume":"52","author":"MK Bakker","year":"2020","unstructured":"Bakker MK, van der Spek RAA, van Rheenen W, Morel S, Bourcier R, Hostettler IC, Alg VS, van Eijk KR, Koido M, Akiyama M, et al. Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors. Nat Genet. 2020;52:1303\u201313. https:\/\/doi.org\/10.1038\/s41588-020-00725-7.","journal-title":"Nat Genet"},{"key":"1186_CR58","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1161\/STROKEAHA.116.012541","volume":"47","author":"R Kleinloog","year":"2016","unstructured":"Kleinloog R, Verweij BH, van der Vlies P, Deelen P, Swertz MA, de Muynck L, Van Damme P, Giuliani F, Regli L, van der Zwan A, et al. RNA sequencing analysis of intracranial aneurysm walls reveals involvement of lysosomes and immunoglobulins in rupture. Stroke. 2016;47:1286\u201393. https:\/\/doi.org\/10.1161\/STROKEAHA.116.012541.","journal-title":"Stroke"},{"key":"1186_CR59","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1038\/s41420-021-00567-0","volume":"7","author":"F Li","year":"2021","unstructured":"Li F, Yan K, Wu L, Zheng Z, Du Y, Liu Z, Zhao L, Li W, Sheng Y, Ren L, et al. Single-cell RNA-seq reveals cellular heterogeneity of mouse carotid artery under disturbed flow. Cell Death Discov. 2021;7:180. https:\/\/doi.org\/10.1038\/s41420-021-00567-0.","journal-title":"Cell Death Discov"},{"key":"1186_CR60","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1016\/j.ajhg.2014.10.018","volume":"95","author":"M Barbier","year":"2014","unstructured":"Barbier M, Gross MS, Aubart M, Hanna N, Kessler K, Guo DC, Tosolini L, Ho-Tin-Noe B, Regalado E, Varret M, et al. MFAP5 loss-of-function mutations underscore the involvement of matrix alteration in the pathogenesis of familial thoracic aortic aneurysms and dissections. Am J Hum Genet. 2014;95:736\u201343. https:\/\/doi.org\/10.1016\/j.ajhg.2014.10.018.","journal-title":"Am J Hum Genet"},{"key":"1186_CR61","doi-asserted-by":"publisher","unstructured":"Sanchez-Infantes D, Nus M, Navas-Madronal M, Fite J, Perez B, Barros-Membrilla AJ, Soto B, Martinez-Gonzalez J, Camacho M, Rodriguez C, et al. Oxidative stress and inflammatory markers in abdominal aortic aneurysm. Antioxidants (Basel). 2021;10:602.\u00a0https:\/\/doi.org\/10.3390\/antiox10040602.","DOI":"10.3390\/antiox10040602"},{"key":"1186_CR62","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1016\/j.wneu.2017.05.175","volume":"105","author":"P Hendrix","year":"2017","unstructured":"Hendrix P, Foreman PM, Harrigan MR, Fisher WS 3rd, Vyas NA, Lipsky RH, Lin M, Walters BC, Tubbs RS, Shoja MM, et al. Association of plasminogen activator inhibitor 1 (SERPINE1) polymorphisms and aneurysmal subarachnoid hemorrhage. World Neurosurg. 2017;105:672\u20137. https:\/\/doi.org\/10.1016\/j.wneu.2017.05.175.","journal-title":"World Neurosurg"},{"key":"1186_CR63","doi-asserted-by":"publisher","first-page":"e737","DOI":"10.1002\/mgg3.737","volume":"7","author":"M Lin","year":"2019","unstructured":"Lin M, Griessenauer CJ, Starke RM, Tubbs RS, Shoja MM, Foreman PM, Vyas NA, Walters BC, Harrigan MR, Hendrix P, et al. Haplotype analysis of SERPINE1 gene: risk for aneurysmal subarachnoid hemorrhage and clinical outcomes. Mol Genet Genomic Med. 2019;7:e737. https:\/\/doi.org\/10.1002\/mgg3.737.","journal-title":"Mol Genet Genomic Med"},{"key":"1186_CR64","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1093\/bioinformatics\/btq126","volume":"26","author":"JC Denny","year":"2010","unstructured":"Denny JC, Ritchie MD, Basford MA, Pulley JM, Bastarache L, Brown-Gentry K, Wang D, Masys DR, Roden DM, Crawford DC. PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene-disease associations. Bioinformatics. 2010;26:1205\u201310. https:\/\/doi.org\/10.1093\/bioinformatics\/btq126.","journal-title":"Bioinformatics"},{"key":"1186_CR65","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1038\/nbt.2749","volume":"31","author":"JC Denny","year":"2013","unstructured":"Denny JC, Bastarache L, Ritchie MD, Carroll RJ, Zink R, Mosley JD, Field JR, Pulley JM, Ramirez AH, Bowton E, et al. Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data. Nat Biotechnol. 2013;31:1102\u201310. https:\/\/doi.org\/10.1038\/nbt.2749.","journal-title":"Nat Biotechnol"}],"container-title":["Translational Stroke Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12975-023-01186-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12975-023-01186-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12975-023-01186-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T14:16:08Z","timestamp":1730297768000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12975-023-01186-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,23]]},"references-count":65,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["1186"],"URL":"https:\/\/doi.org\/10.1007\/s12975-023-01186-w","relation":{},"ISSN":["1868-4483","1868-601X"],"issn-type":[{"value":"1868-4483","type":"print"},{"value":"1868-601X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,23]]},"assertion":[{"value":"6 July 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 July 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 August 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 August 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"MAA is a proctor for Covidien and Codman. The other authors report no conflicts.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}