{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T20:45:07Z","timestamp":1788468307984,"version":"build-2803163510"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T00:00:00Z","timestamp":1703203200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T00:00:00Z","timestamp":1703203200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"VA Merit Grant","award":["5 I01 BX005127"],"award-info":[{"award-number":["5 I01 BX005127"]}]},{"name":"VA RCS Award","award":["5 IK6 BX005690"],"award-info":[{"award-number":["5 IK6 BX005690"]}]},{"name":"NIH","award":["R01 NS130763"],"award-info":[{"award-number":["R01 NS130763"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Transl. Stroke Res."],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1007\/s12975-023-01223-8","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T02:03:46Z","timestamp":1703210626000},"page":"403-409","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Therapeutic Potential of Intravenous miR-21 Mimic after Stroke Following STAIR Criteria"],"prefix":"10.1007","volume":"16","author":[{"given":"Bharath","family":"Chelluboina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soomin","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles Kozhikkadan","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh L.","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raghu","family":"Vemuganti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,12,22]]},"reference":[{"key":"1223_CR1","doi-asserted-by":"crossref","first-page":"105139","DOI":"10.1016\/j.neuint.2021.105139","volume":"149","author":"SL Mehta","year":"2021","unstructured":"Mehta SL, Chokkalla AK, Vemuganti R. Noncoding RNA crosstalk in brain health and Diseases. Neurochem Int. 2021;149:105139.","journal-title":"Neurochem Int"},{"key":"1223_CR2","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3389\/fendo.2018.00402","volume":"9","author":"J O\u2019Brien","year":"2018","unstructured":"O\u2019Brien J, et al. Overview of microRNA biogenesis, mechanisms of actions, and circulation. Front Endocrinol. 2018;9:402.","journal-title":"Front Endocrinol"},{"key":"1223_CR3","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s12017-020-08622-2","volume":"23","author":"A Banerjee","year":"2021","unstructured":"Banerjee A, et al. Microarray profiling reveals distinct circulating miRNAs in aged male and female mice subjected to post-stroke social isolation. Neuromol Med. 2021;23:305\u201314.","journal-title":"Neuromol Med"},{"key":"1223_CR4","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.omtn.2022.11.022","volume":"31","author":"SL Mehta","year":"2023","unstructured":"Mehta SL, et al. CDR1as regulates \u03b1-synuclein-mediated ischemic brain damage by controlling miR-7 availability. Mol Therapy-Nucleic Acids. 2023;31:57\u201367.","journal-title":"Mol Therapy-Nucleic Acids"},{"issue":"1","key":"1223_CR5","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s12975-021-00981-7","volume":"14","author":"SL Mehta","year":"2023","unstructured":"Mehta SL, et al. MicroRNA miR-7 is essential for post-stroke functional recovery. Translational Stroke Research. 2023;14(1):111\u20135.","journal-title":"Translational Stroke Research"},{"issue":"2","key":"1223_CR6","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3390\/ncrna5020035","volume":"5","author":"JA Slota","year":"2019","unstructured":"Slota JA, Booth SA. MicroRNAs in neuroinflammation: implications in Disease pathogenesis, biomarker discovery and therapeutic applications. Non-coding RNA. 2019;5(2):35.","journal-title":"Non-coding RNA"},{"key":"1223_CR7","doi-asserted-by":"crossref","unstructured":"Lopez MS et al. MicroRNA miR-21 decreases post-stroke brain damage in rodents. Translational Stroke Research, 2022: p. 1\u201311.","DOI":"10.1007\/s12975-021-00952-y"},{"issue":"10","key":"1223_CR8","doi-asserted-by":"crossref","first-page":"3138","DOI":"10.1161\/STROKEAHA.120.028978","volume":"51","author":"B Chelluboina","year":"2020","unstructured":"Chelluboina B, et al. Impact of age and sex on \u03b1-Syn (\u03b1-Synuclein) knockdown-mediated poststroke recovery. Stroke. 2020;51(10):3138\u201341.","journal-title":"Stroke"},{"issue":"6","key":"1223_CR9","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1007\/s12975-022-01007-6","volume":"13","author":"KC Morris-Blanco","year":"2022","unstructured":"Morris-Blanco KC, et al. High-dose vitamin C prevents secondary brain damage after Stroke via epigenetic reprogramming of neuroprotective genes. Translational Stroke Research. 2022;13(6):1017\u201336.","journal-title":"Translational Stroke Research"},{"issue":"9","key":"1223_CR10","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1177\/0271678X20943823","volume":"40","author":"N Percie du Sert","year":"2020","unstructured":"Percie du Sert N, et al. The ARRIVE guidelines 2.0: updated guidelines for reporting animal research. J Cereb Blood Flow Metabolism. 2020;40(9):1769\u201377.","journal-title":"J Cereb Blood Flow Metabolism"},{"issue":"11","key":"1223_CR11","doi-asserted-by":"crossref","first-page":"3488","DOI":"10.1177\/0271678X17709185","volume":"37","author":"N Percie du Sert","year":"2017","unstructured":"Percie du Sert N, et al. The IMPROVE guidelines (ischaemia models: procedural refinements of in vivo experiments). J Cereb Blood Flow Metabolism. 2017;37(11):3488\u2013517.","journal-title":"J Cereb Blood Flow Metabolism"},{"issue":"2","key":"1223_CR12","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1177\/0271678X211056392","volume":"42","author":"B Chelluboina","year":"2022","unstructured":"Chelluboina B, et al. Tenascin-C induction exacerbates post-stroke brain damage. J Cereb Blood Flow Metabolism. 2022;42(2):253\u201363.","journal-title":"J Cereb Blood Flow Metabolism"},{"issue":"1","key":"1223_CR13","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1161\/STROKEAHA.122.040401","volume":"54","author":"AK Chokkalla","year":"2023","unstructured":"Chokkalla AK, et al. Cerebroprotective Role of N 6-Methyladenosine demethylase FTO (Fat Mass and obesity-Associated protein) after experimental Stroke. Stroke. 2023;54(1):245\u201354.","journal-title":"Stroke"},{"issue":"26","key":"1223_CR14","doi-asserted-by":"crossref","first-page":"7055","DOI":"10.1523\/JNEUROSCI.1241-16.2016","volume":"36","author":"T Kim","year":"2016","unstructured":"Kim T, et al. Poststroke induction of \u03b1-synuclein mediates ischemic brain damage. J Neurosci. 2016;36(26):7055\u201365.","journal-title":"J Neurosci"},{"issue":"560","key":"1223_CR15","doi-asserted-by":"crossref","first-page":"eaat4285","DOI":"10.1126\/scisignal.aat4285","volume":"11","author":"T Kim","year":"2018","unstructured":"Kim T, et al. The microRNA miR-7a-5p ameliorates ischemic brain damage by repressing \u03b1-synuclein. Sci Signal. 2018;11(560):eaat4285.","journal-title":"Sci Signal"},{"issue":"50","key":"1223_CR16","doi-asserted-by":"crossref","first-page":"16443","DOI":"10.1523\/JNEUROSCI.2943-15.2015","volume":"35","author":"SL Mehta","year":"2015","unstructured":"Mehta SL, Kim T, Vemuganti R. Long noncoding RNA FosDT promotes ischemic brain injury by interacting with REST-associated chromatin-modifying proteins. J Neurosci. 2015;35(50):16443\u20139.","journal-title":"J Neurosci"},{"issue":"3","key":"1223_CR17","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1177\/0271678X20912965","volume":"41","author":"KC Morris-Blanco","year":"2021","unstructured":"Morris-Blanco KC, et al. TET3 regulates DNA hydroxymethylation of neuroprotective genes following focal ischemia. J Cereb Blood Flow Metabolism. 2021;41(3):590\u2013603.","journal-title":"J Cereb Blood Flow Metabolism"},{"key":"1223_CR18","doi-asserted-by":"crossref","first-page":"1124263","DOI":"10.3389\/fphar.2023.1124263","volume":"14","author":"TM Eastin","year":"2023","unstructured":"Eastin TM, et al. Delayed revascularization in acute ischemic Stroke patients. Front Pharmacol. 2023;14:1124263.","journal-title":"Front Pharmacol"},{"issue":"1","key":"1223_CR19","first-page":"35","volume":"1","author":"MS Lopez","year":"2017","unstructured":"Lopez MS, Dempsey RJ, Vemuganti R. The microRNA miR-21 conditions the brain to protect against ischemic and traumatic injuries. Conditioning Med. 2017;1(1):35.","journal-title":"Conditioning Med"},{"key":"1223_CR20","doi-asserted-by":"crossref","unstructured":"Zhang B et al. The Protective Effects of miR-21-Mediated Fibroblast Growth Factor 1 in Rats with Coronary Heart Disease BioMed Research International, 2021. 2021: p.\u00a01\u20139.","DOI":"10.1155\/2021\/3621259"}],"container-title":["Translational Stroke Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12975-023-01223-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12975-023-01223-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12975-023-01223-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T06:00:26Z","timestamp":1744092026000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12975-023-01223-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,22]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["1223"],"URL":"https:\/\/doi.org\/10.1007\/s12975-023-01223-8","relation":{},"ISSN":["1868-4483","1868-601X"],"issn-type":[{"value":"1868-4483","type":"print"},{"value":"1868-601X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,22]]},"assertion":[{"value":"18 September 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 November 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 November 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 December 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}