{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T05:02:18Z","timestamp":1775192538669,"version":"3.50.1"},"reference-count":73,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T00:00:00Z","timestamp":1706832000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T00:00:00Z","timestamp":1706832000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 NS104573"],"award-info":[{"award-number":["R01 NS104573"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RF1 NS083559"],"award-info":[{"award-number":["RF1 NS083559"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 NS104573"],"award-info":[{"award-number":["R01 NS104573"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["BX000347"],"award-info":[{"award-number":["BX000347"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Transl. Stroke Res."],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1007\/s12975-024-01232-1","type":"journal-article","created":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T04:53:36Z","timestamp":1706849616000},"page":"584-599","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Angiotensin II Type 2 Receptor Agonism Alleviates Progressive Post-stroke Cognitive Impairment in Aged Spontaneously Hypertensive Rats"],"prefix":"10.1007","volume":"16","author":[{"given":"Abdulkarim","family":"Alshammari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bindu","family":"Pillai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pradip","family":"Kamat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy W.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asamoah","family":"Bosomtwi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Badruzzaman","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David C.","family":"Hess","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiguo","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Payaningal R.","family":"Somanath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed A.","family":"Sayed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adviye","family":"Ergul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan C.","family":"Fagan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,2,2]]},"reference":[{"issue":"1","key":"1232_CR1","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1161\/STROKEAHA.112.670844","volume":"44","author":"A Douiri","year":"2013","unstructured":"Douiri A, Rudd AG, Wolfe CD. Prevalence of poststroke cognitive impairment: South London Stroke Register 1995\u20132010. Stroke. 2013;44(1):138\u201345.","journal-title":"Stroke"},{"issue":"11","key":"1232_CR2","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1016\/S1474-4422(09)70236-4","volume":"8","author":"ST Pendlebury","year":"2009","unstructured":"Pendlebury ST, Rothwell PM. Prevalence, incidence, and factors associated with pre-stroke and post-stroke dementia: a systematic review and meta-analysis. Lancet Neurol. 2009;8(11):1006\u201318.","journal-title":"Lancet Neurol"},{"issue":"4","key":"1232_CR3","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1161\/STROKEAHA.117.018529","volume":"49","author":"DA Levine","year":"2018","unstructured":"Levine DA, et al. Risk factors for poststroke cognitive decline: the REGARDS study (Reasons for Geographic and Racial Differences in Stroke). Stroke. 2018;49(4):987\u201394.","journal-title":"Stroke"},{"issue":"1","key":"1232_CR4","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1111\/j.1747-4949.2011.00731.x","volume":"7","author":"R Sahathevan","year":"2012","unstructured":"Sahathevan R, Brodtmann A, Donnan GA. Dementia, stroke, and vascular risk factors; a review. Int J Stroke. 2012;7(1):61\u201373.","journal-title":"Int J Stroke"},{"issue":"7","key":"1232_CR5","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1161\/CIRCRESAHA.118.313260","volume":"124","author":"C Iadecola","year":"2019","unstructured":"Iadecola C, Gottesman RF. Neurovascular and cognitive dysfunction in hypertension. Circ Res. 2019;124(7):1025\u201344.","journal-title":"Circ Res"},{"issue":"9","key":"1232_CR6","doi-asserted-by":"publisher","first-page":"2672","DOI":"10.1161\/STR.0b013e3182299496","volume":"42","author":"PB Gorelick","year":"2011","unstructured":"Gorelick PB, et al. Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the American Heart Association\/American Stroke Association. Stroke. 2011;42(9):2672\u2013713.","journal-title":"Stroke"},{"issue":"11","key":"1232_CR7","doi-asserted-by":"publisher","first-page":"3137","DOI":"10.1161\/STROKEAHA.112.651778","volume":"43","author":"M Dichgans","year":"2012","unstructured":"Dichgans M, Zietemann V. Prevention of vascular cognitive impairment. Stroke. 2012;43(11):3137\u201346.","journal-title":"Stroke"},{"issue":"10","key":"1232_CR8","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1038\/s41440-018-0090-9","volume":"41","author":"S Foulquier","year":"2018","unstructured":"Foulquier S, et al. Hypertension-induced cognitive impairment: insights from prolonged angiotensin II infusion in mice. Hypertens Res. 2018;41(10):817\u201327.","journal-title":"Hypertens Res"},{"issue":"12","key":"1232_CR9","doi-asserted-by":"publisher","first-page":"1734","DOI":"10.1001\/archneur.64.12.1734","volume":"64","author":"C Reitz","year":"2007","unstructured":"Reitz C, et al. Hypertension and the risk of mild cognitive impairment. Arch Neurol. 2007;64(12):1734\u201340.","journal-title":"Arch Neurol"},{"issue":"35","key":"1232_CR10","doi-asserted-by":"publisher","first-page":"933","DOI":"10.15585\/mmwr.mm6635e1","volume":"66","author":"Q Yang","year":"2017","unstructured":"Yang Q, et al. Vital signs: recent trends in stroke death rates \u2014 United States, 2000\u20132015. MMWR Morb Mortal Wkly Rep. 2017;66(35):933\u20139.","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"1","key":"1232_CR11","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1161\/01.str.0000437068.30550.cf","volume":"45","author":"DT Lackland","year":"2014","unstructured":"Lackland DT, et al. Factors influencing the decline in stroke mortality: a statement from the American Heart Association\/American Stroke Association. Stroke. 2014;45(1):315\u201353.","journal-title":"Stroke"},{"issue":"12","key":"1232_CR12","doi-asserted-by":"publisher","first-page":"1714","DOI":"10.1002\/alz.12157","volume":"16","author":"BV Zlokovic","year":"2020","unstructured":"Zlokovic BV, et al. Vascular contributions to cognitive impairment and dementia (VCID): a report from the 2018 National Heart, Lung, and Blood Institute and National Institute of Neurological Disorders and Stroke Workshop. Alzheimers Dement. 2020;16(12):1714\u201333.","journal-title":"Alzheimers Dement"},{"issue":"2","key":"1232_CR13","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1007\/s10571-016-0334-7","volume":"36","author":"RA Corriveau","year":"2016","unstructured":"Corriveau RA, et al. The science of vascular contributions to cognitive impairment and dementia (VCID): a framework for advancing research priorities in the cerebrovascular biology of cognitive decline. Cell Mol Neurobiol. 2016;36(2):281\u20138.","journal-title":"Cell Mol Neurobiol"},{"issue":"1","key":"1232_CR14","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s12916-017-0779-7","volume":"15","author":"MD Mijajlovic","year":"2017","unstructured":"Mijajlovic MD, et al. Post-stroke dementia \u2014 a comprehensive review. BMC Med. 2017;15(1):11.","journal-title":"BMC Med"},{"issue":"11","key":"1232_CR15","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1016\/S1474-4422(05)70221-0","volume":"4","author":"D Leys","year":"2005","unstructured":"Leys D, et al. Poststroke dementia. Lancet Neurol. 2005;4(11):752\u20139.","journal-title":"Lancet Neurol"},{"issue":"3","key":"1232_CR16","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/S0301-0082(02)00126-0","volume":"69","author":"ES Rosenzweig","year":"2003","unstructured":"Rosenzweig ES, Barnes CA. Impact of aging on hippocampal function: plasticity, network dynamics, and cognition. Prog Neurobiol. 2003;69(3):143\u201379.","journal-title":"Prog Neurobiol"},{"issue":"Pt B","key":"1232_CR17","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.bbr.2016.05.008","volume":"322","author":"R Hullinger","year":"2017","unstructured":"Hullinger R, Puglielli L. Molecular and cellular aspects of age-related cognitive decline and Alzheimer\u2019s disease. Behav Brain Res. 2017;322(Pt B):191\u2013205.","journal-title":"Behav Brain Res"},{"issue":"5","key":"1232_CR18","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1016\/0197-4580(91)90093-Y","volume":"12","author":"A Caprioli","year":"1991","unstructured":"Caprioli A, et al. Spatial learning and memory in the radial maze: a longitudinal study in rats from 4 to 25 months of age. Neurobiol Aging. 1991;12(5):605\u20137.","journal-title":"Neurobiol Aging"},{"issue":"1","key":"1232_CR19","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.nlm.2006.05.003","volume":"87","author":"C Burger","year":"2007","unstructured":"Burger C, et al. Changes in transcription within the CA1 field of the hippocampus are associated with age-related spatial learning impairments. Neurobiol Learn Mem. 2007;87(1):21\u201341.","journal-title":"Neurobiol Learn Mem"},{"issue":"1","key":"1232_CR20","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1038\/35049064","volume":"2","author":"MW Brown","year":"2001","unstructured":"Brown MW, Aggleton JP. Recognition memory: what are the roles of the perirhinal cortex and hippocampus? Nat Rev Neurosci. 2001;2(1):51\u201361.","journal-title":"Nat Rev Neurosci"},{"issue":"1","key":"1232_CR21","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1161\/HYPERTENSIONAHA.115.05524","volume":"66","author":"A Kruyer","year":"2015","unstructured":"Kruyer A, et al. Chronic hypertension leads to neurodegeneration in the TgSwDI mouse model of Alzheimer\u2019s disease. Hypertension. 2015;66(1):175\u201382.","journal-title":"Hypertension"},{"key":"1232_CR22","doi-asserted-by":"publisher","unstructured":"Jackson L, et al. Within the brain: the renin angiotensin system. Int J Mol Sci. 2018;19(3):876. https:\/\/doi.org\/10.3390\/ijms19030876.","DOI":"10.3390\/ijms19030876"},{"key":"1232_CR23","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.bbr.2017.12.007","volume":"346","author":"HA Ahmed","year":"2018","unstructured":"Ahmed HA, et al. Role of angiotensin system modulation on progression of cognitive impairment and brain MRI changes in aged hypertensive animals - a randomized double- blind pre-clinical study. Behav Brain Res. 2018;346:29\u201340.","journal-title":"Behav Brain Res"},{"issue":"3","key":"1232_CR24","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1097\/01.hjh.0000209990.41304.43","volume":"24","author":"SC Fagan","year":"2006","unstructured":"Fagan SC, et al. Hypertension after experimental cerebral ischemia: candesartan provides neurovascular protection. J Hypertens. 2006;24(3):535\u20139.","journal-title":"J Hypertens"},{"issue":"5","key":"1232_CR25","doi-asserted-by":"publisher","first-page":"1870","DOI":"10.1161\/STROKEAHA.108.537225","volume":"40","author":"A Kozak","year":"2009","unstructured":"Kozak A, et al. Candesartan augments ischemia-induced proangiogenic state and results in sustained improvement after stroke. Stroke. 2009;40(5):1870\u20136.","journal-title":"Stroke"},{"issue":"2","key":"1232_CR26","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1007\/s12975-010-0061-1","volume":"2","author":"W Guan","year":"2011","unstructured":"Guan W, et al. Acute treatment with candesartan reduces early injury after permanent middle cerebral artery occlusion. Transl Stroke Res. 2011;2(2):179\u201385.","journal-title":"Transl Stroke Res"},{"key":"1232_CR27","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1007\/978-3-7091-0693-8_49","volume":"111","author":"W Guan","year":"2011","unstructured":"Guan W, Kozak A, Fagan SC. Drug repurposing for vascular protection after acute ischemic stroke. Acta Neurochir Suppl. 2011;111:295\u20138.","journal-title":"Acta Neurochir Suppl"},{"issue":"9","key":"1232_CR28","doi-asserted-by":"publisher","first-page":"e24551","DOI":"10.1371\/journal.pone.0024551","volume":"6","author":"W Guan","year":"2011","unstructured":"Guan W, et al. Vascular protection by angiotensin receptor antagonism involves differential VEGF expression in both hemispheres after experimental stroke. PLoS ONE. 2011;6(9):e24551.","journal-title":"PLoS ONE"},{"issue":"2","key":"1232_CR29","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1124\/jpet.112.197483","volume":"344","author":"A Alhusban","year":"2013","unstructured":"Alhusban A, et al. AT1 receptor antagonism is proangiogenic in the brain: BDNF a novel mediator. J Pharmacol Exp Ther. 2013;344(2):348\u201359.","journal-title":"J Pharmacol Exp Ther"},{"issue":"12","key":"1232_CR30","doi-asserted-by":"publisher","first-page":"2668","DOI":"10.1007\/s11064-013-1185-y","volume":"38","author":"T Ishrat","year":"2013","unstructured":"Ishrat T, et al. Candesartan reduces the hemorrhage associated with delayed tissue plasminogen activator treatment in rat embolic stroke. Neurochem Res. 2013;38(12):2668\u201377.","journal-title":"Neurochem Res"},{"issue":"1","key":"1232_CR31","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1097\/HJH.0000000000000364","volume":"33","author":"A Alhusban","year":"2015","unstructured":"Alhusban A, et al. Compound 21 is pro-angiogenic in the brain and results in sustained recovery after ischemic stroke. J Hypertens. 2015;33(1):170\u201380.","journal-title":"J Hypertens"},{"key":"1232_CR32","first-page":"560491","volume":"2014","author":"T Ishrat","year":"2014","unstructured":"Ishrat T, et al. Role of matrix metalloproteinase activity in the neurovascular protective effects of Angiotensin antagonism. Stroke Res Treat. 2014;2014:560491.","journal-title":"Stroke Res Treat"},{"issue":"1","key":"1232_CR33","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1007\/s12035-015-9675-3","volume":"54","author":"AY Fouda","year":"2017","unstructured":"Fouda AY, et al. Brain-derived neurotrophic factor knockdown blocks the angiogenic and protective effects of angiotensin modulation after experimental stroke. Mol Neurobiol. 2017;54(1):661\u201370.","journal-title":"Mol Neurobiol"},{"key":"1232_CR34","doi-asserted-by":"publisher","first-page":"105375","DOI":"10.1016\/j.neuint.2022.105375","volume":"158","author":"AY Fouda","year":"2022","unstructured":"Fouda AY, et al. Contralesional angiotensin type 2 receptor activation contributes to recovery in experimental stroke. Neurochem Int. 2022;158:105375.","journal-title":"Neurochem Int"},{"key":"1232_CR35","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1016\/j.bbr.2018.10.010","volume":"359","author":"HA Ahmed","year":"2019","unstructured":"Ahmed HA, et al. Angiotensin receptor (AT2R) agonist C21 prevents cognitive decline after permanent stroke in aged animals\u2014a randomized double- blind pre-clinical study. Behav Brain Res. 2019;359:560\u20139.","journal-title":"Behav Brain Res"},{"issue":"4","key":"1232_CR36","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1007\/s12975-019-00752-5","volume":"11","author":"L Jackson","year":"2020","unstructured":"Jackson L, et al. Delayed administration of angiotensin II type 2 receptor (AT2R) agonist compound 21 prevents the development of post-stroke cognitive impairment in diabetes through the modulation of microglia polarization. Transl Stroke Res. 2020;11(4):762\u201375.","journal-title":"Transl Stroke Res"},{"key":"1232_CR37","doi-asserted-by":"publisher","unstructured":"Jackson-Cowan L, et al. Delayed administration of angiotensin receptor (AT2R) agonist C21 improves survival and preserves sensorimotor outcomes in female diabetic rats post-stroke through modulation of microglial activation. Int J Mol Sci. 2021;22(3):1356. https:\/\/doi.org\/10.3390\/ijms22031356.","DOI":"10.3390\/ijms22031356"},{"key":"1232_CR38","doi-asserted-by":"publisher","first-page":"106904","DOI":"10.1016\/j.vph.2021.106904","volume":"141","author":"W Eldahshan","year":"2021","unstructured":"Eldahshan W, et al. Stimulation of angiotensin II receptor 2 preserves cognitive function and is associated with an enhanced cerebral vascular density after stroke. Vascul Pharmacol. 2021;141:106904.","journal-title":"Vascul Pharmacol"},{"issue":"4","key":"1232_CR39","doi-asserted-by":"publisher","first-page":"e95762","DOI":"10.1371\/journal.pone.0095762","volume":"9","author":"CA McCarthy","year":"2014","unstructured":"McCarthy CA, et al. Direct angiotensin AT2 receptor stimulation using a novel AT2 receptor agonist, compound 21, evokes neuroprotection in conscious hypertensive rats. PLoS ONE. 2014;9(4):e95762.","journal-title":"PLoS ONE"},{"issue":"3","key":"1232_CR40","doi-asserted-by":"publisher","first-page":"1542","DOI":"10.1007\/s12035-014-8830-6","volume":"51","author":"T Ishrat","year":"2015","unstructured":"Ishrat T, et al. Low-dose candesartan enhances molecular mediators of neuroplasticity and subsequent functional recovery after ischemic stroke in rats. Mol Neurobiol. 2015;51(3):1542\u201353.","journal-title":"Mol Neurobiol"},{"issue":"2","key":"1232_CR41","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1038\/jcbfm.2011.133","volume":"32","author":"F Jing","year":"2012","unstructured":"Jing F, et al. Direct stimulation of angiotensin II type 2 receptor enhances spatial memory. J Cereb Blood Flow Metab. 2012;32(2):248\u201355.","journal-title":"J Cereb Blood Flow Metab"},{"issue":"3","key":"1232_CR42","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1038\/jcbfm.2014.221","volume":"35","author":"M Fuchtemeier","year":"2015","unstructured":"Fuchtemeier M, et al. Vascular change and opposing effects of the angiotensin type 2 receptor in a mouse model of vascular cognitive impairment. J Cereb Blood Flow Metab. 2015;35(3):476\u201384.","journal-title":"J Cereb Blood Flow Metab"},{"issue":"12","key":"1232_CR43","doi-asserted-by":"publisher","first-page":"2444","DOI":"10.1097\/HJH.0b013e3283311ba1","volume":"27","author":"P Gelosa","year":"2009","unstructured":"Gelosa P, et al. Stimulation of AT2 receptor exerts beneficial effects in stroke-prone rats: focus on renal damage. J Hypertens. 2009;27(12):2444\u201351.","journal-title":"J Hypertens"},{"issue":"7","key":"1232_CR44","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0180738","volume":"12","author":"DM Bennion","year":"2017","unstructured":"Bennion DM, et al. Post-stroke angiotensin II type 2 receptor activation provides long-term neuroprotection in aged rats. PLoS ONE. 2017;12(7): e0180738.","journal-title":"PLoS ONE"},{"issue":"1","key":"1232_CR45","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1186\/s12974-018-1262-x","volume":"15","author":"HA Ahmed","year":"2018","unstructured":"Ahmed HA, et al. RAS modulation prevents progressive cognitive impairment after experimental stroke: a randomized, blinded preclinical trial. J Neuroinflammation. 2018;15(1):229.","journal-title":"J Neuroinflammation"},{"issue":"1","key":"1232_CR46","first-page":"e100013","volume":"4","author":"SK McCann","year":"2020","unstructured":"McCann SK, Lawrence CB. Comorbidity and age in the modelling of stroke: are we still failing to consider the characteristics of stroke patients? BMJ Open Science. 2020;4(1):e100013.","journal-title":"BMJ Open Science"},{"key":"1232_CR47","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1186\/s40478-014-0169-8","volume":"2","author":"D Kaiser","year":"2014","unstructured":"Kaiser D, et al. Spontaneous white matter damage, cognitive decline and neuroinflammation in middle-aged hypertensive rats: an animal model of early-stage cerebral small vessel disease. Acta Neuropathol Commun. 2014;2:169.","journal-title":"Acta Neuropathol Commun"},{"issue":"5","key":"1232_CR48","doi-asserted-by":"publisher","first-page":"H1192","DOI":"10.1152\/ajpheart.00446.2018","volume":"316","author":"W Eldahshan","year":"2019","unstructured":"Eldahshan W, et al. Angiotensin II type 2 receptor stimulation with compound 21 improves neurological function after stroke in female rats: a pilot study. Am J Physiol Heart Circ Physiol. 2019;316(5):H1192\u2013201.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"1232_CR49","doi-asserted-by":"publisher","first-page":"64","DOI":"10.3389\/fneur.2015.00064","volume":"6","author":"S Ejaz","year":"2015","unstructured":"Ejaz S, et al. What is the optimal duration of middle-cerebral artery occlusion consistently resulting in isolated cortical selective neuronal loss in the spontaneously hypertensive rat? Front Neurol. 2015;6:64.","journal-title":"Front Neurol"},{"issue":"5","key":"1232_CR50","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1177\/0023677218815210","volume":"53","author":"J Yu","year":"2019","unstructured":"Yu J, et al. Reliability of behavioral tests in the middle cerebral artery occlusion model of rat. Lab Anim. 2019;53(5):478\u201390.","journal-title":"Lab Anim"},{"issue":"23","key":"1232_CR51","doi-asserted-by":"publisher","first-page":"8853","DOI":"10.1523\/JNEUROSCI.20-23-08853.2000","volume":"20","author":"RE Clark","year":"2000","unstructured":"Clark RE, Zola SM, Squire LR. Impaired recognition memory in rats after damage to the hippocampus. J Neurosci. 2000;20(23):8853\u201360.","journal-title":"J Neurosci"},{"issue":"2","key":"1232_CR52","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/s10339-011-0430-z","volume":"13","author":"M Antunes","year":"2012","unstructured":"Antunes M, Biala G. The novel object recognition memory: neurobiology, test procedure, and its modifications. Cogn Process. 2012;13(2):93\u2013110.","journal-title":"Cogn Process"},{"issue":"44","key":"1232_CR53","doi-asserted-by":"publisher","first-page":"9811","DOI":"10.1523\/JNEUROSCI.1532-04.2004","volume":"24","author":"CA Buckmaster","year":"2004","unstructured":"Buckmaster CA, et al. Entorhinal cortex lesions disrupt the relational organization of memory in monkeys. J Neurosci. 2004;24(44):9811\u201325.","journal-title":"J Neurosci"},{"key":"1232_CR54","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2021.682935","volume":"15","author":"LB Tucker","year":"2021","unstructured":"Tucker LB, McCabe JT. Measuring anxiety-like behaviors in rodent models of traumatic brain injury. Front Behav Neurosci. 2021;15: 682935.","journal-title":"Front Behav Neurosci"},{"key":"1232_CR55","doi-asserted-by":"publisher","unstructured":"Valvassori SS, Varela RB, Quevedo J. Animal models of mood disorders: focus on bipolar disorders and depression. In Animal models for the study of human disease. Elsevier Inc; 2020. pp. 991\u20131001. https:\/\/doi.org\/10.1016\/B978-0-12-809468-6.00038-3.","DOI":"10.1016\/B978-0-12-809468-6.00038-3"},{"issue":"1","key":"1232_CR56","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.jneumeth.2011.01.019","volume":"197","author":"JP Guilloux","year":"2011","unstructured":"Guilloux JP, et al. Integrated behavioral z-scoring increases the sensitivity and reliability of behavioral phenotyping in mice: relevance to emotionality and sex. J Neurosci Methods. 2011;197(1):21\u201331.","journal-title":"J Neurosci Methods"},{"key":"1232_CR57","doi-asserted-by":"publisher","first-page":"109751","DOI":"10.1016\/j.jneumeth.2022.109751","volume":"384","author":"AK Kraeuter","year":"2023","unstructured":"Kraeuter AK. The use of integrated behavioural z-scoring in behavioural neuroscience - a perspective article. J Neurosci Methods. 2023;384:109751.","journal-title":"J Neurosci Methods"},{"issue":"8","key":"1232_CR58","doi-asserted-by":"publisher","first-page":"e499","DOI":"10.1161\/STROKEAHA.120.031611","volume":"52","author":"NS Rost","year":"2021","unstructured":"Rost NS, et al. Cognitive impairment and dementia after stroke: design and rationale for the DISCOVERY study. Stroke. 2021;52(8):e499\u2013516.","journal-title":"Stroke"},{"issue":"4","key":"1232_CR59","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1002\/alz.12215","volume":"17","author":"D Wilcock","year":"2021","unstructured":"Wilcock D, et al. MarkVCID cerebral small vessel consortium: I. Enrollment, clinical, fluid protocols. Alzheimers Dement. 2021;17(4):704\u201315.","journal-title":"Alzheimers Dement"},{"issue":"1","key":"1232_CR60","doi-asserted-by":"publisher","first-page":"34","DOI":"10.14283\/jpad.2018.41","volume":"6","author":"V Perez-Grijalba","year":"2019","unstructured":"Perez-Grijalba V, et al. Plasma Abeta42\/40 ratio detects early stages of Alzheimer\u2019s disease and correlates with CSF and neuroimaging biomarkers in the AB255 study. J Prev Alzheimers Dis. 2019;6(1):34\u201341.","journal-title":"J Prev Alzheimers Dis"},{"key":"1232_CR61","doi-asserted-by":"publisher","unstructured":"Kautz TF, Mathews JJ, Parent D, Sudduth TL, Liu Q, Wiedner C, Wang C-P, et al. Validation and utility of plasma neurofilament light as a biomarker for vascular cognitive impairment. Alzheimer's & Dementia. 2022;18(S6):e065811. https:\/\/doi.org\/10.1002\/alz.065811.","DOI":"10.1002\/alz.065811"},{"issue":"10","key":"1232_CR62","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1002\/acn3.51652","volume":"9","author":"MM Gonzales","year":"2022","unstructured":"Gonzales MM, et al. A population-based meta-analysis of circulating GFAP for cognition and dementia risk. Ann Clin Transl Neurol. 2022;9(10):1574\u201385.","journal-title":"Ann Clin Transl Neurol"},{"key":"1232_CR63","doi-asserted-by":"publisher","first-page":"113494","DOI":"10.1016\/j.expneurol.2020.113494","volume":"335","author":"E Candelario-Jalil","year":"2021","unstructured":"Candelario-Jalil E, Paul S. Impact of aging and comorbidities on ischemic stroke outcomes in preclinical animal models: a translational perspective. Exp Neurol. 2021;335:113494.","journal-title":"Exp Neurol"},{"issue":"714","key":"1232_CR64","doi-asserted-by":"publisher","first-page":"eadg8656","DOI":"10.1126\/scitranslmed.adg8656","volume":"15","author":"PD Lyden","year":"2023","unstructured":"Lyden PD, et al. A multi-laboratory preclinical trial in rodents to assess treatment candidates for acute ischemic stroke. Sci Transl Med. 2023;15(714):eadg8656.","journal-title":"Sci Transl Med"},{"issue":"2","key":"1232_CR65","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1161\/STROKEAHA.122.040638","volume":"54","author":"A Morais","year":"2023","unstructured":"Morais A, et al. Embracing heterogeneity in the multicenter Stroke Preclinical Assessment Network (SPAN) trial. Stroke. 2023;54(2):620\u201331.","journal-title":"Stroke"},{"key":"1232_CR66","doi-asserted-by":"publisher","first-page":"132","DOI":"10.3389\/fnagi.2017.00132","volume":"9","author":"KC Kern","year":"2017","unstructured":"Kern KC, et al. Blood pressure control in aging predicts cerebral atrophy related to small-vessel white matter lesions. Front Aging Neurosci. 2017;9:132.","journal-title":"Front Aging Neurosci"},{"issue":"5","key":"1232_CR67","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1212\/WNL.59.5.713","volume":"59","author":"IB Goldstein","year":"2002","unstructured":"Goldstein IB, et al. Ambulatory blood pressure and brain atrophy in the healthy elderly. Neurology. 2002;59(5):713\u20139.","journal-title":"Neurology"},{"issue":"2","key":"1232_CR68","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/S0006-8993(01)03270-X","volume":"925","author":"S Shapira","year":"2002","unstructured":"Shapira S, et al. Aging has a complex effect on a rat model of ischemic stroke. Brain Res. 2002;925(2):148\u201358.","journal-title":"Brain Res"},{"issue":"1","key":"1232_CR69","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1007\/s00401-018-1859-2","volume":"136","author":"RM Ritzel","year":"2018","unstructured":"Ritzel RM, et al. Aging alters the immunological response to ischemic stroke. Acta Neuropathol. 2018;136(1):89\u2013110.","journal-title":"Acta Neuropathol"},{"issue":"4","key":"1232_CR70","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1038\/jcbfm.2009.5","volume":"29","author":"F Liu","year":"2009","unstructured":"Liu F, et al. Changes in experimental stroke outcome across the life span. J Cereb Blood Flow Metab. 2009;29(4):792\u2013802.","journal-title":"J Cereb Blood Flow Metab"},{"key":"1232_CR71","first-page":"464701","volume":"2011","author":"F Liu","year":"2011","unstructured":"Liu F, McCullough LD. Middle cerebral artery occlusion model in rodents: methods and potential pitfalls. J Biomed Biotechnol. 2011;2011:464701.","journal-title":"J Biomed Biotechnol"},{"key":"1232_CR72","doi-asserted-by":"publisher","first-page":"282","DOI":"10.3389\/fnbeh.2019.00282","volume":"13","author":"B Meng","year":"2019","unstructured":"Meng B, et al. The investigation of hippocampus-dependent cognitive decline induced by anesthesia\/surgery in mice through integrated behavioral Z-scoring. Front Behav Neurosci. 2019;13:282.","journal-title":"Front Behav Neurosci"},{"issue":"1","key":"1232_CR73","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1186\/s12974-020-01815-3","volume":"17","author":"L Jackson","year":"2020","unstructured":"Jackson L, et al. Microglia knockdown reduces inflammation and preserves cognition in diabetic animals after experimental stroke. J Neuroinflammation. 2020;17(1):137.","journal-title":"J Neuroinflammation"}],"updated-by":[{"DOI":"10.1007\/s12975-024-01263-8","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T00:00:00Z","timestamp":1717545600000}}],"container-title":["Translational Stroke Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12975-024-01232-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12975-024-01232-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12975-024-01232-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T05:02:46Z","timestamp":1746075766000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12975-024-01232-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,2]]},"references-count":73,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["1232"],"URL":"https:\/\/doi.org\/10.1007\/s12975-024-01232-1","relation":{"correction":[{"id-type":"doi","id":"10.1007\/s12975-024-01263-8","asserted-by":"object"}]},"ISSN":["1868-4483","1868-601X"],"issn-type":[{"value":"1868-4483","type":"print"},{"value":"1868-601X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,2]]},"assertion":[{"value":"6 December 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 December 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 January 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 February 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 June 2024","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s12975-024-01263-8","URL":"https:\/\/doi.org\/10.1007\/s12975-024-01263-8","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All experiments were performed following the National Institutes of Health Guide for the Care and Use of Laboratory Animals and ARRIVE guidelines. Experimental protocols were reviewed and approved by the Institutional Animal Care and Use Committee (IACUC) of the Charlie Norwood Veterans Affairs Health Care System, and Augusta University, Augusta, Georgia.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"All authors give their consent and approval for publication of this manuscript.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}