{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T02:30:04Z","timestamp":1784860204643,"version":"3.55.0"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1K23HL157610; 1R21NS135045"],"award-info":[{"award-number":["1K23HL157610; 1R21NS135045"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007880","name":"Johns Hopkins University","doi-asserted-by":"publisher","award":["Magic That Matters foundation grant"],"award-info":[{"award-number":["Magic That Matters foundation grant"]}],"id":[{"id":"10.13039\/100007880","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Transl. Stroke Res."],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s12975-025-01376-8","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T10:14:42Z","timestamp":1754993682000},"page":"2139-2157","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Exploring the Association Between Early PaCO2 Correction Speed and Cerebrovascular Autoregulation in a Porcine Model of Extracorporeal Resuscitation"],"prefix":"10.1007","volume":"16","author":[{"given":"Mingfeng","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila S.","family":"Contreras-Rojas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qihong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaman B.","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Briscoe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos A.","family":"Pardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Rando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Kook","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn","family":"Whitman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Keller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tito","family":"Porras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Min","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,12]]},"reference":[{"key":"1376_CR1","doi-asserted-by":"publisher","first-page":"1117214","DOI":"10.3389\/fmed.2023.1117214","volume":"10","author":"J Cai","year":"2023","unstructured":"Cai J, Abudou H, Chen Y, et al. The effects of ECMO on neurological function recovery of critical patients: a double-edged sword. Front Med. 2023;10: 1117214. https:\/\/doi.org\/10.3389\/fmed.2023.1117214.","journal-title":"Front Med"},{"issue":"11","key":"1376_CR2","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.3390\/cells12111546","volume":"12","author":"S Khanduja","year":"2023","unstructured":"Khanduja S, Kim J, Kang JK, et al. Hypoxic-ischemic brain injury in ECMO: pathophysiology, neuromonitoring, and therapeutic opportunities. Cells. 2023;12(11): 1546. https:\/\/doi.org\/10.3390\/cells12111546.","journal-title":"Cells"},{"key":"1376_CR3","doi-asserted-by":"publisher","first-page":"109671","DOI":"10.1016\/j.resuscitation.2022.12.009","volume":"182","author":"CN Justice","year":"2023","unstructured":"Justice CN, Halperin HR, Vanden Hoek TL, Geocadin RG. Extracorporeal cardiopulmonary resuscitation (eCPR) and cerebral perfusion: a narrative review. Resuscitation. 2023;182: 109671. https:\/\/doi.org\/10.1016\/j.resuscitation.2022.12.009.","journal-title":"Resuscitation"},{"issue":"4","key":"1376_CR4","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/j.healun.2022.10.019","volume":"42","author":"BL Shou","year":"2023","unstructured":"Shou BL, Ong CS, Premraj L, et al. Arterial oxygen and carbon dioxide tension and acute brain injury in extracorporeal cardiopulmonary resuscitation patients: analysis of the extracorporeal life support organization registry. J Heart Lung Transplant. 2023;42(4):503\u201311. https:\/\/doi.org\/10.1016\/j.healun.2022.10.019.","journal-title":"J Heart Lung Transplant"},{"issue":"1","key":"1376_CR5","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1007\/s12028-024-01944-0","volume":"41","author":"SM Cho","year":"2024","unstructured":"Cho SM, Gusdon AM. Assessing acute brain injury after rapid reduction of PaCO2 using plasma biomarkers in patients undergoing ECMO. Neurocrit Care. 2024;41(1):6\u20138. https:\/\/doi.org\/10.1007\/s12028-024-01944-0.","journal-title":"Neurocrit Care"},{"issue":"12","key":"1376_CR6","doi-asserted-by":"publisher","first-page":"3039","DOI":"10.1113\/jphysiol.2011.206052","volume":"589","author":"A Battisti-Charbonney","year":"2011","unstructured":"Battisti-Charbonney A, Fisher J, Duffin J. The cerebrovascular response to carbon dioxide in humans. J Physiol. 2011;589(12):3039\u201348. https:\/\/doi.org\/10.1113\/jphysiol.2011.206052.","journal-title":"J Physiol"},{"issue":"2","key":"1376_CR7","first-page":"161","volume":"2","author":"OB Paulson","year":"1990","unstructured":"Paulson OB, Strandgaard S, Edvinsson L. Cerebral autoregulation. Cerebrovasc Brain Metab Rev. 1990;2(2):161\u201392.","journal-title":"Cerebrovasc Brain Metab Rev"},{"issue":"12","key":"1376_CR8","doi-asserted-by":"publisher","first-page":"1525","DOI":"10.1164\/rccm.202001-0023OC","volume":"201","author":"YA Cavayas","year":"2020","unstructured":"Cavayas YA, Munshi L, Del Sorbo L, Fan E. The early change in PaCO2 after extracorporeal membrane oxygenation initiation is associated with neurological complications. Am J Respir Crit Care Med. 2020;201(12):1525\u201335. https:\/\/doi.org\/10.1164\/rccm.202001-0023OC.","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"1376_CR9","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1097\/MAT.0000000000001838","volume":"69","author":"N Joram","year":"2023","unstructured":"Joram N, Roz\u00e9 JC, Tonna JE, et al. Association between early change in arterial carbon dioxide tension and outcomes in neonates treated by extracorporeal membrane oxygenation. ASAIO J. 2023;69(4):411\u20136. https:\/\/doi.org\/10.1097\/MAT.0000000000001838.","journal-title":"ASAIO J"},{"issue":"5","key":"1376_CR10","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1007\/s00134-016-4318-3","volume":"42","author":"CE Luyt","year":"2016","unstructured":"Luyt CE, Br\u00e9chot N, Demondion P, et al. Brain injury during venovenous extracorporeal membrane oxygenation. Intensive Care Med. 2016;42(5):897\u2013907. https:\/\/doi.org\/10.1007\/s00134-016-4318-3.","journal-title":"Intensive Care Med"},{"issue":"12","key":"1376_CR11","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1097\/MAT.0000000000001699","volume":"68","author":"BL Shou","year":"2022","unstructured":"Shou BL, Ong CS, Zhou AL, et al. Arterial carbon dioxide and acute brain injury in venoarterial extracorporeal membrane oxygenation. ASAIO J. 2022;68(12):1501\u20137. https:\/\/doi.org\/10.1097\/MAT.0000000000001699.","journal-title":"ASAIO J"},{"key":"1376_CR12","doi-asserted-by":"publisher","first-page":"154880","DOI":"10.1016\/j.jcrc.2024.154880","volume":"84","author":"Y Yu","year":"2024","unstructured":"Yu Y, Lettow I, Roedl K, et al. Association of early changes in arterial carbon dioxide with acute brain injury in adult patients with extracorporeal membrane oxygenation: a ten-year retrospective study in a German tertiary care hospital. J Crit Care. 2024;84: 154880. https:\/\/doi.org\/10.1016\/j.jcrc.2024.154880.","journal-title":"J Crit Care"},{"issue":"7","key":"1376_CR13","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1097\/CCM.0000000000004347","volume":"48","author":"A Diehl","year":"2020","unstructured":"Diehl A, Burrell AJC, Udy AA, et al. Association between arterial carbon dioxide tension and clinical outcomes in venoarterial extracorporeal membrane oxygenation*. Crit Care Med. 2020;48(7):977\u201384. https:\/\/doi.org\/10.1097\/CCM.0000000000004347.","journal-title":"Crit Care Med"},{"issue":"14","key":"1376_CR14","doi-asserted-by":"publisher","first-page":"4211","DOI":"10.3390\/jcm11144211","volume":"11","author":"S Hong","year":"2022","unstructured":"Hong S, Jang JH, Yang JH, Cho YH, Ahn J, Ryu JA. Optimal arterial blood gas tensions for the prognosis of favorable neurological outcomes in survivors after extracorporeal cardiopulmonary resuscitation. JCM. 2022;11(14): 4211. https:\/\/doi.org\/10.3390\/jcm11144211.","journal-title":"JCM"},{"key":"1376_CR15","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.resuscitation.2018.09.012","volume":"133","author":"HM Keijzer","year":"2018","unstructured":"Keijzer HM, Hoedemaekers CWE, Meijer FJA, Tonino BAR, Klijn CJM, Hofmeijer J. Brain imaging in comatose survivors of cardiac arrest: pathophysiological correlates and prognostic properties. Resuscitation. 2018;133:124\u201336. https:\/\/doi.org\/10.1016\/j.resuscitation.2018.09.012.","journal-title":"Resuscitation"},{"key":"1376_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jchemneu.2018.04.006","volume":"92","author":"AB Wahul","year":"2018","unstructured":"Wahul AB, Joshi PC, Kumar A, Chakravarty S. Transient global cerebral ischemia differentially affects cortex, striatum and hippocampus in bilateral common carotid arterial occlusion (BCCAo) mouse model. J Chem Neuroanat. 2018;92:1\u201315. https:\/\/doi.org\/10.1016\/j.jchemneu.2018.04.006.","journal-title":"J Chem Neuroanat"},{"issue":"3","key":"1376_CR17","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1161\/01.STR.29.3.695","volume":"29","author":"RM Dijkhuizen","year":"1998","unstructured":"Dijkhuizen RM, Knollema S, Van Der Worp HB, et al. Dynamics of cerebral tissue injury and perfusion after temporary hypoxia-ischemia in the rat: evidence for region-specific sensitivity and delayed damage. Stroke. 1998;29(3):695\u2013704. https:\/\/doi.org\/10.1161\/01.STR.29.3.695.","journal-title":"Stroke"},{"issue":"10","key":"1376_CR18","doi-asserted-by":"publisher","first-page":"e968","DOI":"10.1097\/CCM.0000000000005069","volume":"49","author":"MN Al-Kawaz","year":"2021","unstructured":"Al-Kawaz MN, Canner J, Caturegli G, et al. Duration of hyperoxia and neurologic outcomes in patients undergoing extracorporeal membrane oxygenation. Crit Care Med. 2021;49(10):e968\u201377. https:\/\/doi.org\/10.1097\/CCM.0000000000005069.","journal-title":"Crit Care Med"},{"issue":"1\u20132","key":"1376_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0361-9230(99)00012-X","volume":"49","author":"B F\u00e9lix","year":"1999","unstructured":"F\u00e9lix B, L\u00e9ger ME, Albe-Fessard D, et al. Stereotaxic atlas of the pig brain. Brain Res Bull. 1999;49(1\u20132):1\u2013137. https:\/\/doi.org\/10.1016\/S0361-9230(99)00012-X.","journal-title":"Brain Res Bull"},{"issue":"1","key":"1376_CR20","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1177\/0192623310389621","volume":"39","author":"RH Garman","year":"2011","unstructured":"Garman RH. Histology of the central nervous system. Toxicol Pathol. 2011;39(1):22\u201335. https:\/\/doi.org\/10.1177\/0192623310389621.","journal-title":"Toxicol Pathol"},{"issue":"3","key":"1376_CR21","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1111\/neup.12264","volume":"36","author":"Y Shen","year":"2016","unstructured":"Shen Y, Wang Z, Li F, Sun L. Morphological characteristics of eosinophilic neuronal death after transient unilateral forebrain ischemia in Mongolian gerbils. Neuropathology. 2016;36(3):227\u201336. https:\/\/doi.org\/10.1111\/neup.12264.","journal-title":"Neuropathology"},{"issue":"3","key":"1376_CR22","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/j.neuroscience.2004.02.002","volume":"125","author":"K Ishida","year":"2004","unstructured":"Ishida K, Shimizu H, Hida H, Urakawa S, Ida K, Nishino H. Argyrophilic dark neurons represent various states of neuronal damage in brain insults: some come to die and others survive. Neuroscience. 2004;125(3):633\u201344. https:\/\/doi.org\/10.1016\/j.neuroscience.2004.02.002.","journal-title":"Neuroscience"},{"issue":"1","key":"1376_CR23","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1007\/s00701-024-06085-z","volume":"166","author":"F Velle","year":"2024","unstructured":"Velle F, Lew\u00e9n A, Howells T, H\u00e5nell A, Nilsson P, Enblad P. The effects of cerebral pressure autoregulation status and CPP levels on cerebral metabolism in pediatric traumatic brain injury. Acta Neurochir. 2024;166(1):190. https:\/\/doi.org\/10.1007\/s00701-024-06085-z.","journal-title":"Acta Neurochir"},{"key":"1376_CR24","doi-asserted-by":"publisher","unstructured":"Calviello LA, Donnelly J, Zeiler FA, Thelin EP, Smielewski P, Czosnyka M. Cerebral autoregulation monitoring in acute traumatic brain injury: what\u2019s the evidence? Minerva Anestesiol. 2017;83(8). https:\/\/doi.org\/10.23736\/S0375-9393.17.12043-2","DOI":"10.23736\/S0375-9393.17.12043-2"},{"issue":"S2","key":"1376_CR25","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s12028-014-0022-8","volume":"21","author":"J Claassen","year":"2014","unstructured":"The Participants in the International Multi-disciplinary Consensus Conference on Multimodality Monitoring, Claassen J, Vespa P. Electrophysiologic monitoring in acute brain injury. Neurocrit Care. 2014;21(S2):129\u201347. https:\/\/doi.org\/10.1007\/s12028-014-0022-8.","journal-title":"Neurocrit Care"},{"issue":"3","key":"1376_CR26","doi-asserted-by":"publisher","first-page":"143","DOI":"10.3390\/medicina56030143","volume":"56","author":"BK Bajpai","year":"2020","unstructured":"Bajpai BK, Preiksaitis A, Vosylius S, Rocka S. Association between the cerebral autoregulation index (pressure reactivity), patient\u2019s clinical outcome, and quality of ABP(t) and ICP(t) signals for CA monitoring. Medicina. 2020;56(3): 143. https:\/\/doi.org\/10.3390\/medicina56030143.","journal-title":"Medicina"},{"issue":"3","key":"1376_CR27","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1161\/STROKEAHA.108.531020","volume":"40","author":"J Diedler","year":"2009","unstructured":"Diedler J, Sykora M, Rupp A, et al. Impaired cerebral vasomotor activity in spontaneous intracerebral hemorrhage. Stroke. 2009;40(3):815\u20139. https:\/\/doi.org\/10.1161\/STROKEAHA.108.531020.","journal-title":"Stroke"},{"issue":"1","key":"1376_CR28","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1097\/00006123-199707000-00005","volume":"41","author":"M Czosnyka","year":"1997","unstructured":"Czosnyka M, Smielewski P, Kirkpatrick P, Laing RJ, Menon D, Pickard JD. Continuous assessment of the cerebral vasomotor reactivity in head injury. Neurosurgery. 1997;41(1):11\u20139. https:\/\/doi.org\/10.1097\/00006123-199707000-00005.","journal-title":"Neurosurgery"},{"issue":"3","key":"1376_CR29","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.neulet.2003.08.049","volume":"352","author":"KI Fritz","year":"2003","unstructured":"Fritz KI, Zubrow AB, Ashraf QM, Mishra OP, Delivoria-Papadopoulos M. The effect of hypocapnia (PaCO2 27 mmHg) on CaM kinase IV activity, Bax\/Bcl-2 protein expression and DNA fragmentation in the cerebral cortex of newborn piglets. Neurosci Lett. 2003;352(3):211\u20135. https:\/\/doi.org\/10.1016\/j.neulet.2003.08.049.","journal-title":"Neurosci Lett"},{"issue":"2","key":"1376_CR30","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1203\/01.PDR.0000148718.47137.9B","volume":"57","author":"KI Fritz","year":"2005","unstructured":"Fritz KI, Zubrow A, Mishra OP, Delivoria-Papadopoulos M. Hypercapnia-induced modifications of neuronal function in the cerebral cortex of newborn piglets. Pediatr Res. 2005;57(2):299\u2013304. https:\/\/doi.org\/10.1203\/01.PDR.0000148718.47137.9B.","journal-title":"Pediatr Res"},{"issue":"5","key":"1376_CR31","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1203\/00006450-200111000-00009","volume":"50","author":"KI Fritz","year":"2001","unstructured":"Fritz KI, Ashraf QM, Mishra OP, Delivoria-Papadopoulos M. Effect of moderate hypocapnic ventilation on nuclear DNA fragmentation and energy metabolism in the cerebral cortex of newborn piglets. Pediatr Res. 2001;50(5):586\u20139. https:\/\/doi.org\/10.1203\/00006450-200111000-00009.","journal-title":"Pediatr Res"},{"issue":"1","key":"1376_CR32","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s12974-017-1051-y","volume":"15","author":"HG Ding","year":"2018","unstructured":"Ding HG, Deng YY, Yang R, et al. Hypercapnia induces IL-1\u03b2 overproduction via activation of NLRP3 inflammasome: implication in cognitive impairment in hypoxemic adult rats. J Neuroinflammation. 2018;15(1): 4. https:\/\/doi.org\/10.1186\/s12974-017-1051-y.","journal-title":"J Neuroinflammation"},{"issue":"11","key":"1376_CR33","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1111\/cns.13435","volume":"26","author":"H Ding","year":"2020","unstructured":"Ding H, Li Y, Li X, et al. Hypercapnia promotes microglial pyroptosis via inhibiting mitophagy in hypoxemic adult rats. CNS Neurosci Ther. 2020;26(11):1134\u201346. https:\/\/doi.org\/10.1111\/cns.13435.","journal-title":"CNS Neurosci Ther"},{"issue":"2","key":"1376_CR34","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1038\/jcbfm.2013.193","volume":"34","author":"YY Fan","year":"2014","unstructured":"Fan YY, Shen Z, He P, et al. A novel neuroprotective strategy for ischemic stroke: transient mild acidosis treatment by CO2 inhalation at reperfusion. J Cereb Blood Flow Metab. 2014;34(2):275\u201383. https:\/\/doi.org\/10.1038\/jcbfm.2013.193.","journal-title":"J Cereb Blood Flow Metab"},{"issue":"1","key":"1376_CR35","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1007\/s12028-023-01923-x","volume":"41","author":"S Thiara","year":"2024","unstructured":"Thiara S, Stukas S, Hoiland R, et al. Characterizing the relationship between arterial carbon dioxide trajectory and serial brain biomarkers with central nervous system injury during veno-venous extracorporeal membrane oxygenation: a prospective cohort study. Neurocrit Care. 2024;41(1):20\u20138. https:\/\/doi.org\/10.1007\/s12028-023-01923-x.","journal-title":"Neurocrit Care"},{"issue":"7","key":"1376_CR36","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1097\/PCC.0000000000003216","volume":"24","author":"N Shah","year":"2023","unstructured":"Shah N, Li X, Shanmugham P, et al. Early changes in arterial partial pressure of carbon dioxide and blood pressure after starting extracorporeal membrane oxygenation in children: extracorporeal life support organization database study of neurologic complications*. Pediatr Crit Care Med. 2023;24(7):541\u201350. https:\/\/doi.org\/10.1097\/PCC.0000000000003216.","journal-title":"Pediatr Crit Care Med"},{"issue":"5","key":"1376_CR37","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1161\/01.STR.28.5.1049","volume":"28","author":"M Zoli","year":"1997","unstructured":"Zoli M, Grimaldi R, Ferrari R, Zini I, Agnati LF. Short- and long-term changes in striatal neurons and astroglia after transient forebrain ischemia in rats. Stroke. 1997;28(5):1049\u201359. https:\/\/doi.org\/10.1161\/01.STR.28.5.1049.","journal-title":"Stroke"},{"key":"1376_CR38","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.pneurobio.2018.07.003","volume":"169","author":"N Tambasco","year":"2018","unstructured":"Tambasco N, Romoli M, Calabresi P. Selective basal ganglia vulnerability to energy deprivation: experimental and clinical evidences. Prog Neurobiol. 2018;169:55\u201375. https:\/\/doi.org\/10.1016\/j.pneurobio.2018.07.003.","journal-title":"Prog Neurobiol"},{"issue":"6","key":"1376_CR39","doi-asserted-by":"publisher","first-page":"e194","DOI":"10.1161\/CIR.0000000000000697","volume":"140","author":"AA Topjian","year":"2019","unstructured":"Topjian AA, De Caen A, Wainwright MS, et al. Pediatric post\u2013cardiac arrest care: a scientific statement from the American Heart Association. Circulation. 2019;140(6):e194\u2013233. https:\/\/doi.org\/10.1161\/CIR.0000000000000697.","journal-title":"Circulation"},{"issue":"8","key":"1376_CR40","doi-asserted-by":"publisher","first-page":"e763","DOI":"10.1097\/CCM.0000000000002379","volume":"45","author":"S Silva","year":"2017","unstructured":"Silva S, Peran P, Kerhuel L, et al. Brain gray matter MRI morphometry for neuroprognostication after cardiac arrest. Crit Care Med. 2017;45(8):e763\u201371. https:\/\/doi.org\/10.1097\/CCM.0000000000002379.","journal-title":"Crit Care Med"},{"issue":"1","key":"1376_CR41","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/s12028-010-9457-8","volume":"14","author":"D Greer","year":"2011","unstructured":"Greer D, Scripko P, Bartscher J, et al. Serial MRI changes in comatose cardiac arrest patients. Neurocrit Care. 2011;14(1):61\u20137. https:\/\/doi.org\/10.1007\/s12028-010-9457-8.","journal-title":"Neurocrit Care"},{"issue":"10","key":"1376_CR42","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.3174\/ajnr.A4839","volume":"37","author":"JM Mettenburg","year":"2016","unstructured":"Mettenburg JM, Agarwal V, Baldwin M, Rittenberger JC. Discordant observation of brain injury by MRI and malignant electroencephalography patterns in comatose survivors of cardiac arrest following therapeutic hypothermia. AJNR Am J Neuroradiol. 2016;37(10):1787\u201393. https:\/\/doi.org\/10.3174\/ajnr.A4839.","journal-title":"AJNR Am J Neuroradiol"},{"issue":"2","key":"1376_CR43","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1007\/s12028-021-01201-8","volume":"35","author":"N Joram","year":"2021","unstructured":"Joram N, Beqiri E, Pezzato S, et al. Impact of arterial carbon dioxide and oxygen content on cerebral autoregulation monitoring among children supported by ECMO. Neurocrit Care. 2021;35(2):480\u201390. https:\/\/doi.org\/10.1007\/s12028-021-01201-8.","journal-title":"Neurocrit Care"},{"issue":"1","key":"1376_CR44","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/s13613-023-01138-5","volume":"13","author":"P Masi","year":"2023","unstructured":"Masi P, Bagate F, Tuffet S, et al. Dual titration of minute ventilation and sweep gas flow to control carbon dioxide variations in patients on venovenous extracorporeal membrane oxygenation. Ann Intensive Care. 2023;13(1):45. https:\/\/doi.org\/10.1186\/s13613-023-01138-5.","journal-title":"Ann Intensive Care"},{"issue":"5","key":"1376_CR45","doi-asserted-by":"publisher","first-page":"2489","DOI":"10.1021\/acschemneuro.8b00737","volume":"10","author":"MY Zhu","year":"2019","unstructured":"Zhu MY, Zhang DL, Zhou C, Chai Z. Mild acidosis protects neurons during oxygen-glucose deprivation by reducing loss of mitochondrial respiration. ACS Chem Neurosci. 2019;10(5):2489\u201397. https:\/\/doi.org\/10.1021\/acschemneuro.8b00737.","journal-title":"ACS Chem Neurosci"},{"key":"1376_CR46","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.brainres.2013.08.014","volume":"1533","author":"T Tao","year":"2013","unstructured":"Tao T, Liu Y, Zhang J, Xu Y, Li W, Zhao M. Therapeutic hypercapnia improves functional recovery and attenuates injury via antiapoptotic mechanisms in a rat focal cerebral ischemia\/reperfusion model. Brain Res. 2013;1533:52\u201362. https:\/\/doi.org\/10.1016\/j.brainres.2013.08.014.","journal-title":"Brain Res"},{"issue":"10","key":"1376_CR47","doi-asserted-by":"publisher","first-page":"e897","DOI":"10.1097\/CCM.0000000000004498","volume":"48","author":"SM Cho","year":"2020","unstructured":"Cho SM, Canner J, Chiarini G, et al. Modifiable risk factors and mortality from ischemic and hemorrhagic strokes in patients receiving venoarterial extracorporeal membrane oxygenation: results from the Extracorporeal Life Support Organization registry. Crit Care Med. 2020;48(10):e897\u2013905. https:\/\/doi.org\/10.1097\/CCM.0000000000004498.","journal-title":"Crit Care Med"},{"issue":"1","key":"1376_CR48","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1097\/CCM.0000000000004707","volume":"49","author":"SM Cho","year":"2021","unstructured":"Cho SM, Canner J, Caturegli G, et al. Risk factors of ischemic and hemorrhagic strokes during venovenous extracorporeal membrane oxygenation: analysis of data from the extracorporeal life support organization registry. Crit Care Med. 2021;49(1):91\u2013101. https:\/\/doi.org\/10.1097\/CCM.0000000000004707.","journal-title":"Crit Care Med"},{"issue":"9","key":"1376_CR49","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1097\/CCM.0000000000003223","volume":"46","author":"R Sutter","year":"2018","unstructured":"Sutter R, Tisljar K, Marsch S. Acute neurologic complications during extracorporeal membrane oxygenation: a systematic review. Crit Care Med. 2018;46(9):1506\u201313. https:\/\/doi.org\/10.1097\/CCM.0000000000003223.","journal-title":"Crit Care Med"},{"issue":"5","key":"1376_CR50","doi-asserted-by":"publisher","first-page":"e400","DOI":"10.1097\/CCM.0000000000004286","volume":"48","author":"T Granja","year":"2020","unstructured":"Granja T, Hohenstein K, Sch\u00fcssel P, et al. Multi-modal characterization of the coagulopathy associated with extracorporeal membrane oxygenation. Crit Care Med. 2020;48(5):e400\u20138. https:\/\/doi.org\/10.1097\/CCM.0000000000004286.","journal-title":"Crit Care Med"},{"issue":"10","key":"1376_CR51","doi-asserted-by":"publisher","first-page":"e0240117","DOI":"10.1371\/journal.pone.0240117","volume":"15","author":"KA Popugaev","year":"2020","unstructured":"Popugaev KA, Bakharev SA, Kiselev KV, et al. Clinical and pathophysiologic aspects of ECMO-associated hemorrhagic complications. PLoS ONE. 2020;15(10): e0240117. https:\/\/doi.org\/10.1371\/journal.pone.0240117.","journal-title":"PLoS ONE"},{"key":"1376_CR52","doi-asserted-by":"publisher","first-page":"731106","DOI":"10.3389\/fmed.2021.731106","volume":"8","author":"W Hu","year":"2021","unstructured":"Hu W, Zhang J, Wang M, et al. Clinical features and risk factors analysis for hemorrhage in adults on ECMO. Front Med. 2021;8: 731106. https:\/\/doi.org\/10.3389\/fmed.2021.731106.","journal-title":"Front Med"},{"issue":"4","key":"1376_CR53","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1097\/MAT.0000000000001013","volume":"66","author":"SM Cho","year":"2020","unstructured":"Cho SM, Ziai W, Mayasi Y, et al. Noninvasive neurological monitoring in extracorporeal membrane oxygenation. ASAIO J. 2020;66(4):388\u201393. https:\/\/doi.org\/10.1097\/MAT.0000000000001013.","journal-title":"ASAIO J"},{"issue":"6","key":"1376_CR54","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1177\/1550059419892757","volume":"52","author":"SM Cho","year":"2021","unstructured":"Cho SM, Choi CW, Whitman G, et al. Neurophysiological findings and brain injury pattern in patients on ECMO. Clin EEG Neurosci. 2021;52(6):462\u20139. https:\/\/doi.org\/10.1177\/1550059419892757.","journal-title":"Clin EEG Neurosci"}],"container-title":["Translational Stroke Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12975-025-01376-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12975-025-01376-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12975-025-01376-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T20:03:07Z","timestamp":1762632187000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12975-025-01376-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,12]]},"references-count":54,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["1376"],"URL":"https:\/\/doi.org\/10.1007\/s12975-025-01376-8","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-6559635\/v1","asserted-by":"object"}]},"ISSN":["1868-4483","1868-601X"],"issn-type":[{"value":"1868-4483","type":"print"},{"value":"1868-601X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,12]]},"assertion":[{"value":"29 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 July 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 August 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 August 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal procedures were conducted in accordance with the Animal Welfare Act regulations and the Public Health Service Policy on Humane Care and Use of Laboratory Animals. The study protocol was reviewed and approved by the Johns Hopkins University Animal Care and Use Committee (Protocol Number SW21M451).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}