{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T03:10:12Z","timestamp":1773112212117,"version":"3.50.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Transl. Stroke Res."],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1007\/s12975-025-01398-2","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T02:24:26Z","timestamp":1764642266000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clusters of Pediatric Brain Arteriovenous Malformations Link Spatial Distribution, Clinical Presentation, and Outcomes"],"prefix":"10.1007","volume":"17","author":[{"given":"Sandro","family":"Benichi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Benzakoun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gr\u00e9goire","family":"Boulouis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matei","family":"Militaru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lelio","family":"Guida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Bourgeois","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K\u00e9vin","family":"Beccaria","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Boddaert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Oppenheim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillaume","family":"Canaud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manoelle","family":"Kossorotoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Blauwblomme","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Naggara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,12,2]]},"reference":[{"key":"1398_CR1","doi-asserted-by":"publisher","first-page":"3654","DOI":"10.1161\/STROKEAHA.119.025783","volume":"50","author":"G Boulouis","year":"2019","unstructured":"Boulouis G, Blauwblomme T, Hak JF, Benichi S, Kirton A, Meyer P, et al. Nontraumatic pediatric intracerebral hemorrhage. Stroke. 2019;50:3654\u201361.","journal-title":"Stroke"},{"key":"1398_CR2","doi-asserted-by":"publisher","first-page":"661","DOI":"10.3171\/2020.9.PEDS20608","volume":"27","author":"G Boulouis","year":"2021","unstructured":"Boulouis G, Stricker S, Benichi S, Hak J-F, Gariel F, Kossorotoff M, et al. Mortality and functional outcome after pediatric intracerebral hemorrhage: cohort study and meta-analysis. J Neurosurg Pediatr. 2021;27:661\u20137.","journal-title":"J Neurosurg Pediatr"},{"key":"1398_CR3","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.8","volume":"1","author":"MT Lawton","year":"2015","unstructured":"Lawton MT, Rutledge WC, Kim H, Stapf C, Whitehead KJ, Li DY, et al. Brain arteriovenous malformations. Nat Rev Dis Primers. 2015;1:15008.","journal-title":"Nat Rev Dis Primers"},{"key":"1398_CR4","doi-asserted-by":"publisher","unstructured":"Garcia JH, Winkler EA, Morshed RA, Lu A, Ammanuel SG, Saggi S, et al. Factors associated with seizures at initial presentation in pediatric patients with cerebral arteriovenous malformations. J Neurosurg Pediatr. 2021(6). https:\/\/doi.org\/10.3171\/2021.6.PEDS21126.","DOI":"10.3171\/2021.6.PEDS21126"},{"key":"1398_CR5","doi-asserted-by":"publisher","first-page":"451","DOI":"10.3171\/2014.9.PEDS14194","volume":"15","author":"T Blauwblomme","year":"2015","unstructured":"Blauwblomme T, Naggara O, Brunelle F, Gr\u00e9vent D, Puget S, Di Rocco F, et al. Arterial spin labeling magnetic resonance imaging: toward noninvasive diagnosis and follow-up of pediatric brain arteriovenous malformations. J Neurosurg Pediatr. 2015;15:451\u20138.","journal-title":"J Neurosurg Pediatr"},{"key":"1398_CR6","doi-asserted-by":"publisher","DOI":"10.1007\/s00062-019-00861-6","author":"Q Alias","year":"2019","unstructured":"Alias Q, Boulouis G, Blauwblomme T, Benichi S, Beccaria K, Gariel F, et al. First line Onyx embolization in ruptured pediatric arteriovenous malformations\u202f: safety and efficacy. Clin Neuroradiol. 2019. https:\/\/doi.org\/10.1007\/s00062-019-00861-6.","journal-title":"Clin Neuroradiol"},{"key":"1398_CR7","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1016\/j.ejrad.2011.01.086","volume":"81","author":"J Luo","year":"2012","unstructured":"Luo J, Lv X, Jiang C, Wu Z. Brain AVM characteristics and age. Eur J Radiol. 2012;81:780\u20133.","journal-title":"Eur J Radiol"},{"key":"1398_CR8","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.3174\/ajnr.A3361","volume":"34","author":"JJS Shankar","year":"2013","unstructured":"Shankar JJS, Menezes RJ, Pohlmann-Eden B, Wallace C, terBrugge K, Krings T. Angioarchitecture of brain AVM determines the presentation with seizures: proposed scoring system. AJNR Am J Neuroradiol. 2013;34:1028\u201334.","journal-title":"AJNR Am J Neuroradiol"},{"key":"1398_CR9","doi-asserted-by":"crossref","unstructured":"Hak J-F, Boulouis G, Kerleroux B, Benichi S, Stricker S, Gariel F et al. Pediatric brain arteriovenous malformation recurrence: a cohort study, systematic review and meta-analysis. J Neurointerventional Surg. 2021;neurintsurg-2021-017777.","DOI":"10.1136\/neurintsurg-2021-017777"},{"key":"1398_CR10","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1161\/STROKEAHA.107.493080","volume":"39","author":"PL Lasjaunias","year":"2008","unstructured":"Lasjaunias PL, Landrieu P, Rodesch G, Alvarez H, Ozanne A, Holmin S, et al. Cerebral proliferative angiopathy: clinical and angiographic description of an entity different from cerebral AVMs. Stroke. 2008;39:878\u201385.","journal-title":"Stroke"},{"key":"1398_CR11","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1212\/WNL.0b013e3182494d40","volume":"78","author":"B Garcin","year":"2012","unstructured":"Garcin B, Houdart E, Porcher R, Manchon E, Saint-Maurice JP, Bresson D, et al. Epileptic seizures at initial presentation in patients with brain arteriovenous malformation. Neurology. 2012;78:626\u201331.","journal-title":"Neurology"},{"key":"1398_CR12","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1136\/jnnp-2013-305123","volume":"85","author":"F Galletti","year":"2014","unstructured":"Galletti F, Costa C, Cupini LM, Eusebi P, Hamam M, Caputo N, et al. Brain arteriovenous malformations and seizures: an Italian study. J Neurol Neurosurg Psychiatry. 2014;85:284\u20138.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"1398_CR13","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1148\/radiol.2019190491","volume":"293","author":"A Roux","year":"2019","unstructured":"Roux A, Roca P, Edjlali M, Sato K, Zanello M, Dezamis E, et al. MRI atlas of IDH wild-type supratentorial glioblastoma: probabilistic maps of phenotype, management, and outcomes. Radiology. 2019;293:633\u201343.","journal-title":"Radiology"},{"key":"1398_CR14","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.jbi.2018.02.019","volume":"80","author":"N Garcelon","year":"2018","unstructured":"Garcelon N, Neuraz A, Salomon R, Faour H, Benoit V, Delapalme A, et al. A clinician friendly data warehouse oriented toward narrative reports: Dr. warehouse. J Biomed Inform. 2018;80:52\u201363.","journal-title":"J Biomed Inform"},{"key":"1398_CR15","doi-asserted-by":"publisher","first-page":"160044","DOI":"10.1038\/sdata.2016.44","volume":"3","author":"KJ Gorgolewski","year":"2016","unstructured":"Gorgolewski KJ, Auer T, Calhoun VD, Craddock RC, Das S, Duff EP, et al. The brain imaging data structure, a format for organizing and describing outputs of neuroimaging experiments. Sci Data. 2016;3:160044.","journal-title":"Sci Data"},{"key":"1398_CR16","doi-asserted-by":"publisher","first-page":"e1975","DOI":"10.1212\/WNL.0000000000012863","volume":"97","author":"B Kerleroux","year":"2021","unstructured":"Kerleroux B, Benzakoun J, Janot K, Dargazanli C, Eraya DD, Ben Hassen W, et al. Relevance of brain regions\u2019 eloquence assessment in patients with a large ischemic core treated with mechanical thrombectomy. Neurology. 2021;97:e1975\u201385.","journal-title":"Neurology"},{"key":"1398_CR17","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1111\/epi.13670","volume":"58","author":"RS Fisher","year":"2017","unstructured":"Fisher RS, Cross JH, French JA, Higurashi N, Hirsch E, Jansen FE, et al. Operational classification of seizure types by the international league against epilepsy: position paper of the ILAE commission for classification and terminology. Epilepsia. 2017;58:522\u201330.","journal-title":"Epilepsia"},{"key":"1398_CR18","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1111\/epi.13709","volume":"58","author":"IE Scheffer","year":"2017","unstructured":"Scheffer IE, Berkovic S, Capovilla G, Connolly MB, French J, Guilhoto L, et al. <Emphasis Type=\"SmallCaps\">ILAE<\/Emphasis>classification of the epilepsies: position paper of the <Emphasis Type=\"SmallCaps\">ILAE<\/Emphasis>Commission for Classification and Terminology. Epilepsia. 2017;58:512\u201321.","journal-title":"Epilepsia"},{"key":"1398_CR19","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1136\/adc.84.2.120","volume":"84","author":"M Crouchman","year":"2001","unstructured":"Crouchman M, Rossiter L, Colaco T, Forsyth R. A practical outcome scale for paediatric head injury. Arch Dis Child. 2001;84:120\u20134.","journal-title":"Arch Dis Child"},{"key":"1398_CR20","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1016\/S0140-6736(07)61602-X","volume":"370","author":"E von Elm","year":"2007","unstructured":"von Elm E, Altman DG, Egger M, Pocock SJ, G\u00f8tzsche PC, Vandenbroucke JP. The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. Lancet. 2007;370:1453\u20137.","journal-title":"Lancet"},{"key":"1398_CR21","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1007\/s00701-024-06105-y","volume":"166","author":"JE Basilio-Flores","year":"2024","unstructured":"Basilio-Flores JE, Aguilar-Melgar JA, Pacheco-Fernandez Baca H. Location-based clinical and angiographic profile of brain arteriovenous malformations - a single-center observational study. Acta Neurochir (Wien). 2024;166:211.","journal-title":"Acta Neurochir (Wien)"},{"key":"1398_CR22","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1186\/s12883-015-0402-5","volume":"15","author":"S Liu","year":"2015","unstructured":"Liu S, Chen H-X, Mao Q, You C, Xu J-G. Factors associated with seizure occurrence and long-term seizure control in pediatric brain arteriovenous malformation: a retrospective analysis of 89 patients. BMC Neurol. 2015;15:155.","journal-title":"BMC Neurol"},{"key":"1398_CR23","doi-asserted-by":"publisher","first-page":"2358","DOI":"10.3174\/ajnr.A6824","volume":"41","author":"L Garzelli","year":"2020","unstructured":"Garzelli L, Shotar E, Blauwblomme T, Sourour N, Alias Q, Stricker S, et al. Risk factors for early brain AVM rupture: cohort study of pediatric and adult patients. AJNR Am J Neuroradiol. 2020;41:2358\u201363.","journal-title":"AJNR Am J Neuroradiol"},{"key":"1398_CR24","doi-asserted-by":"publisher","DOI":"10.1227\/neu.0000000000002986","author":"AT Hale","year":"2024","unstructured":"Hale AT, Liu S, Huang F, Song Y, Crowley MR, Crossman DK, et al. Endoluminal biopsy for vein of Galen malformation. Neurosurgery. 2024. https:\/\/doi.org\/10.1227\/neu.0000000000002986.","journal-title":"Neurosurgery"},{"key":"1398_CR25","doi-asserted-by":"publisher","DOI":"10.1126\/science.abi7377","author":"EA Winkler","year":"2022","unstructured":"Winkler EA, Kim CN, Ross JM, Garcia JH, Gil E, Oh I, et al. A single-cell atlas of the normal and malformed human brain vasculature. Science. 2022. https:\/\/doi.org\/10.1126\/science.abi7377.","journal-title":"Science"},{"key":"1398_CR26","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1038\/s41586-024-07493-y","volume":"632","author":"T W\u00e4lchli","year":"2024","unstructured":"W\u00e4lchli T, Ghobrial M, Schwab M, Takada S, Zhong H, Suntharalingham S, et al. Single-cell atlas of the human brain vasculature across development, adulthood and disease. Nature. 2024;632:603\u201313.","journal-title":"Nature"},{"key":"1398_CR27","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1056\/NEJMoa1709449","volume":"378","author":"SI Nikolaev","year":"2018","unstructured":"Nikolaev SI, Vetiska S, Bonilla X, Boudreau E, Jauhiainen S, Rezai Jahromi B, et al. Somatic activating KRAS mutations in arteriovenous malformations of the brain. N Engl J Med. 2018;378:250\u201361.","journal-title":"N Engl J Med"},{"key":"1398_CR28","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1182\/hematology.2024000598","volume":"2024","author":"E Seront","year":"2024","unstructured":"Seront E, Queisser A, Boon LM, Vikkula M. Molecular landscape and classification of vascular anomalies. Hematol Am Soc Hematol Educ Program. 2024;2024:700\u20138.","journal-title":"Hematol Am Soc Hematol Educ Program"},{"key":"1398_CR29","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1056\/NEJMoa2309160","volume":"391","author":"A Fraissenon","year":"2024","unstructured":"Fraissenon A, Bayard C, Morin G, Benichi S, Hoguin C, Protic S, et al. Sotorasib for vascular malformations associated with KRAS G12C mutation. N Engl J Med. 2024;391:334\u201342.","journal-title":"N Engl J Med"}],"container-title":["Translational Stroke Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12975-025-01398-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12975-025-01398-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12975-025-01398-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T15:04:19Z","timestamp":1773068659000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12975-025-01398-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,2]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["1398"],"URL":"https:\/\/doi.org\/10.1007\/s12975-025-01398-2","relation":{},"ISSN":["1868-4483","1868-601X"],"issn-type":[{"value":"1868-4483","type":"print"},{"value":"1868-601X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,2]]},"assertion":[{"value":"31 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 October 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 November 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 December 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have nothing to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosures"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"2"}}