{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:59:06Z","timestamp":1790366346574,"version":"4.1.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Henan Provincial Medical Science and Technology Research Program","award":["SBGJ202303001"],"award-info":[{"award-number":["SBGJ202303001"]}]},{"name":"Capacity Building and Continuing Education Program of the National Health Commission","award":["GWJJ2023100101"],"award-info":[{"award-number":["GWJJ2023100101"]}]},{"name":"National Natural Science Foundation of China","award":["8257072246"],"award-info":[{"award-number":["8257072246"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Henan Provincial Key Research and Development Program","award":["241111313200"],"award-info":[{"award-number":["241111313200"]}]},{"name":"Henan Provincial Youth Science Foundation","award":["252300421604"],"award-info":[{"award-number":["252300421604"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Transl. Stroke Res."],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1007\/s12975-026-01495-w","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T06:22:45Z","timestamp":1790317365000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exogenous Hydrogen Sulfide Donors Suppress Neointimal Hyperplasia by Modulating Mitochondrial Dysfunction in Vascular Smooth Muscle Cells"],"prefix":"10.1007","volume":"17","author":[{"given":"Yanyan","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenqing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenming","family":"Si","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianxiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4168-8158","authenticated-orcid":false,"given":"Yingkun","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,25]]},"reference":[{"issue":"2","key":"1495_CR1","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1161\/STROKEAHA.123.043630","volume":"55","author":"LH Chen","year":"2024","unstructured":"Chen LH, Spagnolo-Allende A, Yang D, et al. Epidemiology, Pathophysiology, and Imaging of Atherosclerotic Intracranial Disease[J\/OL]. Stroke. 2024;55(2):311\u201323.","journal-title":"Stroke"},{"key":"1495_CR2","doi-asserted-by":"publisher","first-page":"110685","DOI":"10.1016\/j.jneumeth.2026.110685","volume":"429","author":"F Meng","year":"2026","unstructured":"Meng F, Xiang H, Huo M, et al. Research progress in vivo, in vitro, and in silico models of intracranial atherosclerotic stenosis[J\/OL]. J Neurosci Methods. 2026;429:110685.","journal-title":"J Neurosci Methods"},{"issue":"32","key":"1495_CR3","doi-asserted-by":"publisher","first-page":"e03033","DOI":"10.1002\/advs.202503033","volume":"12","author":"Z Wang","year":"2025","unstructured":"Wang Z, He Y, Yuan W, et al. Identification of Schwann Cells in Human Intracranial Arteries: Potential Regulatory Role in Atherosclerotic Plaque Progression[J\/OL]. Adv Sci. 2025;12(32):e03033.","journal-title":"Adv Sci"},{"issue":"24","key":"1495_CR4","doi-asserted-by":"publisher","first-page":"4060","DOI":"10.3390\/cells11244060","volume":"11","author":"HY Tang","year":"2022","unstructured":"Tang HY, Chen AQ, Zhang H, et al. Vascular Smooth Muscle Cells Phenotypic Switching in Cardiovascular Diseases[J\/OL]. Cells. 2022;11(24):4060.","journal-title":"Cells"},{"issue":"3","key":"1495_CR5","doi-asserted-by":"publisher","first-page":"100043","DOI":"10.1016\/j.engmed.2024.100043","volume":"1","author":"Z Wang","year":"2024","unstructured":"Wang Z, Sheng J, Lu G, et al. Shedding new light on atherosclerosis therapeutics: Nanomedicines targeting atherosclerotic immune microenvironment[J\/OL]. EngMedicine. 2024;1(3):100043.","journal-title":"EngMedicine"},{"issue":"4","key":"1495_CR6","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1161\/CIRCRESAHA.114.300505","volume":"114","author":"DJ Polhemus","year":"2014","unstructured":"Polhemus DJ, Lefer DJ. Emergence of Hydrogen Sulfide as an Endogenous Gaseous Signaling Molecule in Cardiovascular Disease[J\/OL]. Circul Res. 2014;114(4):730\u20137.","journal-title":"Circul Res"},{"key":"1495_CR7","doi-asserted-by":"publisher","first-page":"701681","DOI":"10.3389\/fpls.2021.701681","volume":"12","author":"D Huang","year":"2021","unstructured":"Huang D, Jing G, Zhang L, et al. Interplay Among Hydrogen Sulfide, Nitric Oxide, Reactive Oxygen Species, and Mitochondrial DNA Oxidative Damage[J\/OL]. Front Plant Sci. 2021;12:701681.","journal-title":"Front Plant Sci"},{"key":"1495_CR8","doi-asserted-by":"publisher","first-page":"125792","DOI":"10.1016\/j.ijpharm.2025.125792","volume":"680","author":"X Li","year":"2025","unstructured":"Li X, An Y, Xu M, et al. Hydrogen sulfide and its donors for the treatment of traumatic brain injury: A comprehensive review[J\/OL]. Int J Pharm. 2025;680:125792.","journal-title":"Int J Pharm"},{"issue":"8","key":"1495_CR9","doi-asserted-by":"publisher","first-page":"1795","DOI":"10.1111\/bph.12246","volume":"169","author":"Z Liu","year":"2013","unstructured":"Liu Z, Han Y, Li L, et al. The hydrogen sulfide donor, GYY 4137, exhibits anti-atherosclerotic activity in high fat fed apolipoprotein E\u2013\/\u2013 mice[J\/OL]. Br J Pharmacol. 2013;169(8):1795\u2013809.","journal-title":"Br J Pharmacol"},{"issue":"10","key":"1495_CR10","doi-asserted-by":"publisher","first-page":"2270","DOI":"10.1080\/15548627.2022.2026097","volume":"18","author":"Z Chen","year":"2022","unstructured":"Chen Z, Ouyang C, Zhang H, et al. Vascular smooth muscle cell-derived hydrogen sulfide promotes atherosclerotic plaque stability via TFEB (transcription factor EB)-mediated autophagy[J\/OL]. Autophagy. 2022;18(10):2270\u201387.","journal-title":"Autophagy"},{"key":"1495_CR11","doi-asserted-by":"publisher","first-page":"102847","DOI":"10.1016\/j.redox.2023.102847","volume":"66","author":"K Magierowska","year":"2023","unstructured":"Magierowska K, W\u00f3jcik-Grzybek D, Korbut E, et al. The mitochondria-targeted sulfide delivery molecule attenuates drugs-induced gastropathy. Involvement of heme oxygenase pathway.[J\/OL]. Redox Biol. 2023;66:102847.","journal-title":"Redox Biol"},{"key":"1495_CR12","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.phrs.2016.08.019","volume":"113","author":"D Ger\u0151","year":"2016","unstructured":"Ger\u0151 D, Torregrossa R, Perry A, et al. The novel mitochondria-targeted hydrogen sulfide (H2S) donors AP123 and AP39 protect against hyperglycemic injury in microvascular endothelial cells in vitro[J\/OL]. Pharmacol Res. 2016;113:186\u201398.","journal-title":"Pharmacol Res"},{"key":"1495_CR13","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.niox.2014.04.008","volume":"41","author":"B Szczesny","year":"2014","unstructured":"Szczesny B, M\u00f3dis K, Yanagi K, et al. AP39, a novel mitochondria-targeted hydrogen sulfide donor, stimulates cellular bioenergetics, exerts cytoprotective effects and protects against the loss of mitochondrial DNA integrity in oxidatively stressed endothelial cells in vitro[J\/OL]. Nitric Oxide. 2014;41:120\u201330.","journal-title":"Nitric Oxide"},{"issue":"2","key":"1495_CR14","doi-asserted-by":"publisher","first-page":"80","DOI":"10.2478\/jtim-2020-0013","volume":"8","author":"P Wang","year":"2020","unstructured":"Wang P, Zhang N, Wu B, et al. The role of mitochondria in vascular calcification[J\/OL]. J Translational Intern Med. 2020;8(2):80\u201390.","journal-title":"J Translational Intern Med"},{"issue":"1","key":"1495_CR15","doi-asserted-by":"publisher","first-page":"2627689","DOI":"10.1080\/10717544.2026.2627689","volume":"33","author":"Y Liu","year":"2026","unstructured":"Liu Y, Luo N, Xi X, et al. Mitochondrial dysfunction and applications of mitochondrial-targeted delivery systems in atherosclerosis[J\/OL]. Drug Delivery. 2026;33(1):2627689.","journal-title":"Drug Delivery"},{"issue":"3","key":"1495_CR16","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1152\/physrev.00026.2013","volume":"94","author":"DB Zorov","year":"2014","unstructured":"Zorov DB, Juhaszova M, Sollott SJ. Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release[J\/OL]. Physiol Rev. 2014;94(3):909\u201350.","journal-title":"Physiol Rev"},{"issue":"1","key":"1495_CR17","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/s41392-023-01547-9","volume":"8","author":"W Chen","year":"2023","unstructured":"Chen W, Zhao H, Li Y. Mitochondrial dynamics in health and disease: mechanisms and potential targets[J\/OL]. Signal Transduct Target Therapy. 2023;8(1):333.","journal-title":"Signal Transduct Target Therapy"},{"issue":"6","key":"1495_CR18","doi-asserted-by":"publisher","first-page":"5785","DOI":"10.3390\/ijms24065785","volume":"24","author":"M Zerihun","year":"2023","unstructured":"Zerihun M, Sukumaran S, Qvit N. The Drp1-Mediated Mitochondrial Fission Protein Interactome as an Emerging Core Player in Mitochondrial Dynamics and Cardiovascular Disease Therapy[J\/OL]. Int J Mol Sci. 2023;24(6):5785.","journal-title":"Int J Mol Sci"},{"issue":"6","key":"1495_CR19","doi-asserted-by":"publisher","first-page":"3136","DOI":"10.3390\/ijms25063136","volume":"25","author":"C Yorn","year":"2024","unstructured":"Yorn C, Kim H, Jeong K. Influence of DNA Methylation on Vascular Smooth Muscle Cell Phenotypic Switching[J\/OL]. Int J Mol Sci. 2024;25(6):3136.","journal-title":"Int J Mol Sci"},{"issue":"1","key":"1495_CR20","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1038\/s41419-020-2240-7","volume":"11","author":"YF Liu","year":"2020","unstructured":"Liu YF, Zhu JJ, Yu Tian X, et al. Hypermethylation of mitochondrial DNA in vascular smooth muscle cells impairs cell contractility[J\/OL]. Cell Death Dis. 2020;11(1):35.","journal-title":"Cell Death Dis"},{"issue":"1","key":"1495_CR21","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1146\/annurev-biochem-060815-014402","volume":"85","author":"CM Gustafsson","year":"2016","unstructured":"Gustafsson CM, Falkenberg M, Larsson NG. Maintenance and Expression of Mammalian Mitochondrial DNA[J\/OL]. Annu Rev Biochem. 2016;85(1):133\u201360.","journal-title":"Annu Rev Biochem"},{"issue":"6","key":"1495_CR22","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1038\/s41440-024-01670-2","volume":"47","author":"K Ueda","year":"2024","unstructured":"Ueda K, Shibata S. Mitochondrial fission: a new mechanism of hypertension and cardiovascular remodeling induced by Angiotensin II[J\/OL]. Hypertens Res. 2024;47(6):1741\u20133.","journal-title":"Hypertens Res"},{"key":"1495_CR23","doi-asserted-by":"crossref","unstructured":"Jin JY, Wei XX, Zhi XL, et al. Drp1-dependent mitochondrial fission in cardiovascular disease[J\/OL]. Acta Pharmacol Sin. 2021;42(5):655\u2013664.","DOI":"10.1038\/s41401-020-00518-y"},{"key":"1495_CR24","doi-asserted-by":"publisher","first-page":"934231","DOI":"10.3389\/fendo.2022.934231","volume":"13","author":"C Zhu","year":"2022","unstructured":"Zhu C, Liu Q, Li X, et al. Hydrogen sulfide: A new therapeutic target in vascular diseases[J\/OL]. Front Endocrinol. 2022;13:934231.","journal-title":"Front Endocrinol"},{"issue":"10","key":"1495_CR25","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.3390\/antiox13101158","volume":"13","author":"C Munteanu","year":"2024","unstructured":"Munteanu C, Popescu C, Vl\u0103dulescu-Trandafir AI, et al. Signaling Paradigms of H2S-Induced Vasodilation: A Comprehensive Review[J\/OL]. Antioxidants. 2024;13(10):1158.","journal-title":"Antioxidants"},{"key":"1495_CR26","doi-asserted-by":"crossref","unstructured":"Wu Q, Chen Y, Wang Z et al. Mangiferin Inhibits PDGF-BB-Induced Proliferation and Migration of Rat Vascular Smooth Muscle Cells and Alleviates Neointimal Formation in Mice through the AMPK\/Drp1 Axis[J\/OL]. Oxidative Medicine and Cellular Longevity, 2021, 2021: 3119953.","DOI":"10.1155\/2021\/3119953"},{"issue":"1","key":"1495_CR27","doi-asserted-by":"publisher","first-page":"36552","DOI":"10.1038\/srep36552","volume":"6","author":"H Wang","year":"2016","unstructured":"Wang H, Robichaux WG, Wang Z, et al. Inhibition of Epac1 suppresses mitochondrial fission and reduces neointima formation induced by vascular injury[J\/OL]. Sci Rep. 2016;6(1):36552.","journal-title":"Sci Rep"},{"issue":"6","key":"1495_CR28","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/j.devcel.2017.02.020","volume":"40","author":"EA Bordt","year":"2017","unstructured":"Bordt EA, Clerc P, Roelofs BA, et al. The Putative Drp1 Inhibitor mdivi-1 Is a Reversible Mitochondrial Complex I Inhibitor that Modulates Reactive Oxygen Species[J\/OL]. Dev Cell. 2017;40(6):583\u2013e5946.","journal-title":"Dev Cell"},{"issue":"24","key":"1495_CR29","doi-asserted-by":"publisher","first-page":"7358","DOI":"10.7150\/jca.61379","volume":"12","author":"GP Zou","year":"2021","unstructured":"Zou GP, Yu CX, Shi SL, et al. Mitochondrial Dynamics Mediated by DRP1 and MFN2 Contributes to Cisplatin Chemoresistance in Human Ovarian Cancer SKOV3 cells[J\/OL]. J Cancer. 2021;12(24):7358\u201373.","journal-title":"J Cancer"},{"key":"1495_CR30","doi-asserted-by":"crossref","unstructured":"Su ZDZ, Li CQ, Wang HW, et al. Inhibition of DRP1-dependent mitochondrial fission by Mdivi-1 alleviates atherosclerosis through the modulation of M1 polarization[J\/OL]. J Transl Med. 2023;21(1):427.","DOI":"10.1186\/s12967-023-04270-9"},{"issue":"1","key":"1495_CR31","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1038\/s41467-025-68274-3","volume":"17","author":"MD Nguyen","year":"2026","unstructured":"Nguyen MD, Sierra-Magro A, Singh V, et al. Structural basis for late maturation steps of mitochondrial respiratory chain complex IV within the human respirasome[J\/OL]. Nat Commun. 2026;17(1):1550.","journal-title":"Nat Commun"},{"key":"1495_CR32","doi-asserted-by":"publisher","first-page":"876639","DOI":"10.3389\/fcvm.2022.876639","volume":"9","author":"D Macabrey","year":"2022","unstructured":"Macabrey D, Longchamp A, D\u00e9glise S, et al. Clinical Use of Hydrogen Sulfide to Protect Against Intimal Hyperplasia[J\/OL]. Front Cardiovasc Med. 2022;9:876639.","journal-title":"Front Cardiovasc Med"},{"issue":"7","key":"1495_CR33","doi-asserted-by":"publisher","first-page":"740","DOI":"10.3390\/biom14070740","volume":"14","author":"X Sun","year":"2024","unstructured":"Sun X, Wu S, Mao C, et al. Therapeutic Potential of Hydrogen Sulfide in Ischemia and Reperfusion Injury[J\/OL]. Biomolecules. 2024;14(7):740.","journal-title":"Biomolecules"},{"key":"1495_CR34","doi-asserted-by":"publisher","first-page":"122912","DOI":"10.1016\/j.biomaterials.2024.122912","volume":"315","author":"G Li","year":"2025","unstructured":"Li G, Zhang R, Chen K, et al. Zinc sulfide nanoparticles serve as gas slow-release bioreactors for H2S therapy of ischemic stroke[J\/OL]. Biomaterials. 2025;315:122912.","journal-title":"Biomaterials"},{"issue":"5","key":"1495_CR35","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.3390\/antiox12051075","volume":"12","author":"O Abu Shelbayeh","year":"2023","unstructured":"Abu Shelbayeh O, Arroum T, Morris S, et al. PGC-1\u03b1 Is a Master Regulator of Mitochondrial Lifecycle and ROS Stress Response[J\/OL]. Antioxidants. 2023;12(5):1075.","journal-title":"Antioxidants<br>"},{"issue":"1","key":"1495_CR36","doi-asserted-by":"publisher","first-page":"2340","DOI":"10.1038\/s41467-022-29945-7","volume":"13","author":"V Sidarala","year":"2022","unstructured":"Sidarala V, Zhu J, Levi-D\u2019Ancona E, et al. Mitofusin 1 and 2 regulation of mitochondrial DNA content is a critical determinant of glucose homeostasis[J\/OL]. Nat Commun. 2022;13(1):2340.","journal-title":"Nat Commun"},{"issue":"3","key":"1495_CR37","doi-asserted-by":"publisher","first-page":"433","DOI":"10.3390\/biom15030433","volume":"15","author":"P Zanfardino","year":"2025","unstructured":"Zanfardino P, Amati A, Perrone M, et al. The Balance of MFN2 and OPA1 in Mitochondrial Dynamics, Cellular Homeostasis, and Disease[J\/OL]. Biomolecules. 2025;15(3):433.","journal-title":"Biomolecules"}],"container-title":["Translational Stroke Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12975-026-01495-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12975-026-01495-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12975-026-01495-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:02:28Z","timestamp":1790362948000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12975-026-01495-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,25]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["1495"],"URL":"https:\/\/doi.org\/10.1007\/s12975-026-01495-w","relation":{},"ISSN":["1868-4483","1868-601X"],"issn-type":[{"value":"1868-4483","type":"print"},{"value":"1868-601X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,25]]},"assertion":[{"value":"22 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 July 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 September 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 September 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All animal experiments were conducted in strict accordance with national regulations and guidelines for the care and use of laboratory animals. The experimental protocols were reviewed and approved by the Animal Ethics Committee of Zhengzhou University (approval No. ZZU-LAC20240802), and all procedures complied with approved ethical standards.","order":1,"name":"Ethics","label":"Animal Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","label":"Competing Interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"106"}}