{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:21:14Z","timestamp":1790691674131,"version":"4.1.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2012,4,14]],"date-time":"2012-04-14T00:00:00Z","timestamp":1334361600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Physiol Biochem"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1007\/s13105-012-0167-x","type":"journal-article","created":{"date-parts":[[2012,4,13]],"date-time":"2012-04-13T18:07:18Z","timestamp":1334340438000},"page":"521-528","source":"Crossref","is-referenced-by-count":13,"title":["The role of nitric oxide and l-type calcium channel blocker in the contractility of rabbit ileum in vitro"],"prefix":"10.1007","volume":"68","author":[{"given":"Merhan","family":"Ragy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eman","family":"Elbassuoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,4,14]]},"reference":[{"key":"167_CR1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0014-2999(94)90166-X","volume":"259","author":"L Bartho","year":"1994","unstructured":"Bartho L, Lefebvre RA (1994) Nitric oxide causes contraction in the rat isolated small intestine. Eur J Pharmacol 259:101\u2013104","journal-title":"Eur J Pharmacol"},{"key":"167_CR2","first-page":"53","volume":"329","author":"L Bartho","year":"1995","unstructured":"Bartho L, Lefebvre RA (1995) Nitric oxide-mediated contraction in enteric smooth muscle. Arch Int Pharmacodyn Ther 329:53\u201366","journal-title":"Arch Int Pharmacodyn Ther"},{"key":"167_CR3","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1111\/j.2042-7158.1985.tb05062.x","volume":"37","author":"DB Beleslin","year":"1985","unstructured":"Beleslin DB, Samardzic R, Terzic B, Jovanovic-Micic D (1985) The effect of nifedipine and verapamyl on the pendular movements of rabbit isolated ileum. J Pharmacol Physiol 37:276\u2013277","journal-title":"J Pharmacol Physiol"},{"key":"167_CR4","first-page":"G747","volume":"285","author":"C Caballero-Alomar","year":"2003","unstructured":"Caballero-Alomar C, Santos C, Lopez D, Metafile MT, Puig-Parellada P (2003) Sources and implications of basal nitric oxide in spontaneous contractions of guinea pig Taenia caeci. Am J Physiol 285:G747\u2013G753","journal-title":"Am J Physiol"},{"issue":"2","key":"167_CR5","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/0006-291X(91)91274-G","volume":"181","author":"A Calignano","year":"1991","unstructured":"Calignano A, Moncada S, Di Rosa M (1991) Endogenous nitric oxide modulates morphine-induced constipation. Biochem Biophys Res Commun 181(2):889\u2013893","journal-title":"Biochem Biophys Res Commun"},{"issue":"5","key":"167_CR6","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1139\/y97-081","volume":"75","author":"FS Cayabyab","year":"1997","unstructured":"Cayabyab FS, Jim\u00e9nez M, Vergara P, deBruin H, Daniel EE (1997) Influence of nitric oxide and vasoactive intestinal peptide on the spontaneous and triggered electrical and mechanical activities of the canine ileum. Can J Physiol Pharmacol 75(5):383\u2013397","journal-title":"Can J Physiol Pharmacol"},{"key":"167_CR7","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1007\/s002100100480","volume":"364","author":"G Costa","year":"2001","unstructured":"Costa G, Labadia A, Triguero D, Jimenez E, Garcia-Pascual A (2001) Nitrergic relaxation in urethral smooth muscle: involvement of potassium channels and alternative redox forms of NO. Naun Schmiedebergs Arch Pharmacol 364:516\u2013523","journal-title":"Naun Schmiedebergs Arch Pharmacol"},{"key":"167_CR8","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1161\/res.89.7.560","volume":"89","author":"LL Cribbs","year":"2001","unstructured":"Cribbs LL (2001) Vascular smooth muscle calcium channels. Could \u201cT\u201d be a target? Circ Res 89:560\u2013562","journal-title":"Circ Res"},{"issue":"1","key":"167_CR9","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0163-7258(93)90024-8","volume":"60","author":"F Ponti De","year":"1993","unstructured":"De Ponti F, Giaroni C, Cosentino M, Lecchini S, Frigo G (1993) Calcium-channel blockers and gastrointestinal motility: basic and clinical aspects. Pharmacol Ther 60(1):121\u2013148","journal-title":"Pharmacol Ther"},{"issue":"4","key":"167_CR10","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/0016-5085(85)90584-0","volume":"89","author":"M Donowitz","year":"1985","unstructured":"Donowitz M, Levin S, Powers G, Elta G, Cohen P, Cheng H (1985) Ca2+ channel blockers stimulate ileal and colonic water absorption. Gastroenterology 89(4):858\u2013866","journal-title":"Gastroenterology"},{"key":"167_CR11","doi-asserted-by":"crossref","unstructured":"Evans ED, Mangel AW (2011) Depolarization-stimulated contractility of gastrointestinal smooth muscle in calcium-free solution. ISRN Gastroenterology, volume 2011, Article ID 692528, 3 pages","DOI":"10.5402\/2011\/692528"},{"key":"167_CR12","first-page":"809","volume":"45","author":"F Gocer","year":"1995","unstructured":"Gocer F, Yaris E, Tuncer M, Kayaalp SO (1995) Effect of nitrovasodilators on the rhythmic contractions of guinea-pig isolated sphincter of Oddi. Arzneimittelforschung 45:809\u2013812","journal-title":"Arzneimittelforschung"},{"key":"167_CR13","first-page":"639","volume":"55","author":"L Grasa","year":"2004","unstructured":"Grasa L, Rebollar E, Arruebo MP (2004) The role of Ca in the contractility of rabbit small intestine in vitro. J Physiol Pharmacol 55:639\u2013650","journal-title":"J Physiol Pharmacol"},{"issue":"3","key":"167_CR14","first-page":"407","volume":"56","author":"L Grasa","year":"2005","unstructured":"Grasa L, Rebollar E, Arruebo MP, Plaza MA, Murillo MD (2005) The role of NO in the contractility of rabbit small intestine in vitro: effect of K\u2009+\u2009channels. J Physiol Pharmacol 56(3):407\u2013419","journal-title":"J Physiol Pharmacol"},{"key":"167_CR15","first-page":"432","volume":"244","author":"JR Grider","year":"1988","unstructured":"Grider JR, Makhlouf GM (1988) Contraction mediated by Ca++ release in circular and Ca++ influx in longitudinal intestinal muscle cells. J Pharmacol Exp Ther 244:432\u2013437","journal-title":"J Pharmacol Exp Ther"},{"key":"167_CR16","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1365-2982.1996.tb00258.x","volume":"8","author":"L Grossi","year":"1996","unstructured":"Grossi L, Falcucci M, Lapenna D, Marzio L (1996) Effect of nitric oxide on propagated clusters of spontaneous motor waves in an ex vivo rabbit intestinal preparation. Neurogastroenterol Motil 8:201\u2013205","journal-title":"Neurogastroenterol Motil"},{"key":"167_CR17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.33549\/physiolres.930255","volume":"52","author":"MB Hansen","year":"2003","unstructured":"Hansen MB (2003) Neurohumoral control of gastrointestinal motility. Physiol Res 52:1\u201330","journal-title":"Physiol Res"},{"key":"167_CR18","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0014-2999(91)90307-C","volume":"202","author":"K Irie","year":"1991","unstructured":"Irie K, Muraki T, Furukawa F, Nomoto T (1991) l-NG-nitro-arginine inhibits nicotine-induced relaxation of isolated rat duodenum. Eur J Pharmacol 202:285\u2013288","journal-title":"Eur J Pharmacol"},{"key":"167_CR19","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1159\/000139421","volume":"53","author":"AA Izzo","year":"1996","unstructured":"Izzo AA, Mascolo N, Maiolino P, Capasso F (1996) Nitric oxide-donating compounds and cyclic GMP depress the spontaneous contractile activity of the isolated rabbit jejunum. Pharmacology 53:109\u2013113","journal-title":"Pharmacology"},{"key":"167_CR20","first-page":"L899","volume":"278","author":"LJ Janssen","year":"2000","unstructured":"Janssen LJ, Premji M, Lu-Chao H, Cox G, Keshavjee S (2000) NO(+) but not NO radical relaxes airway smooth muscle via cGMP-independent release of internal Ca(2+). Am J Physiol 278:L899\u2013L905","journal-title":"Am J Physiol"},{"key":"167_CR21","first-page":"157","volume":"49","author":"H Karaki","year":"1997","unstructured":"Karaki H, Ozaki H, Hori M, Mitsui-Saito M, Amano K, Harada K, Miyamoto S, Nakazawa H, Won KJ, Sato K (1997) Calcium movements, distribution, and function in smooth muscle. Pharmacol Rev 49:157\u2013230","journal-title":"Pharmacol Rev"},{"issue":"4","key":"167_CR22","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1097\/00005344-199510000-00013","volume":"26","author":"Y Kishi","year":"1995","unstructured":"Kishi Y, Watanabe T, Makita T, Sakita S, Watanabe R, Ashikaga T, Numano F (1995) Effect of nifedipine on cyclic GMP turnover in cultured coronary smooth muscle cells. J Cardiovasc Pharmacol 26(4):590\u2013595","journal-title":"J Cardiovasc Pharmacol"},{"key":"167_CR23","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1152\/physrev.1998.78.3.811","volume":"78","author":"H Kuriyama","year":"1998","unstructured":"Kuriyama H, Kitamura K, Itoh T, Inoue R (1998) Physiological features of visceral smooth muscle cells, with special reference to receptors and ion channels. Physiol Rev 78:811\u2013920","journal-title":"Physiol Rev"},{"key":"167_CR24","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1292\/jvms.63.389","volume":"63","author":"S Kwon","year":"2001","unstructured":"Kwon S, Chung S, Ahn D, Yeon D, Nam T (2001) Mechanism of carbon monoxide-induced relaxation in the guinea pig ileal smooth muscle. J Vet Med Sci 63:389\u2013393","journal-title":"J Vet Med Sci"},{"key":"167_CR25","doi-asserted-by":"crossref","unstructured":"Lefebvre RA, Bartho L (1997) Mechanism of nitric oxide-induced contraction in the rat isolated small intestine. Br J Pharmacol 120:975\u2013981","DOI":"10.1038\/sj.bjp.0700996"},{"key":"167_CR26","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0014-2999(95)00348-O","volume":"284","author":"SLR Martins","year":"1995","unstructured":"Martins SLR, De Oliveira RB, Ballejo G (1995) Rat duodenum nitrergic-induced relaxations are cGMP-independent and apamin-sensitive. Eur J Pharmacol 284:265\u2013270","journal-title":"Eur J Pharmacol"},{"key":"167_CR27","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/j.1472-8206.2008.00579.x","volume":"22","author":"NM Matsuda","year":"2008","unstructured":"Matsuda NM, Lemos MC, Feitosa RL (2008) The effect of guanylate cyclase inhibitors on non-adrenergic and non-cholinergic neurogenic relaxations of the South American opossum lower esophageal sphincter. Fundam Clin Pharmacol 22:299\u2013304","journal-title":"Fundam Clin Pharmacol"},{"key":"167_CR28","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1111\/j.1365-2982.2004.00574.x","volume":"16","author":"NM Matsuda","year":"2004","unstructured":"Matsuda NM, Miller SM, Sha L, Farrugia G, Szurszewski JH (2004) Mediators of non-adrenergic non-cholinergic inhibitory neurotransmission in porcine jejunum. Neurogastroenterol Motil 16:605\u2013612","journal-title":"Neurogastroenterol Motil"},{"key":"167_CR29","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1006\/bbrc.1998.9844","volume":"253","author":"B Modzelewska","year":"1998","unstructured":"Modzelewska B, Sipowicz MA, Saavedra JE, Keefer LK, Kostrzewska A (1998) Involvement of K\u2009+\u2009ATP channels in nitric oxide-induced inhibition of spontaneous contractile activity of the nonpregnant human myometrium. Biochem Biophys Res Commun 253:653\u2013657","journal-title":"Biochem Biophys Res Commun"},{"key":"167_CR30","first-page":"109","volume":"43","author":"S Moncada","year":"1991","unstructured":"Moncada S, Palmer RMJ, Higgs EA (1991) Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 43:109\u2013142","journal-title":"Pharmacol Rev"},{"issue":"3","key":"167_CR31","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1113\/jphysiol.2003.043737","volume":"550","author":"FH Mourad","year":"2003","unstructured":"Mourad FH, Barada KA, Abdel-Malak N, Bou Rached NA, Khoury CI, Saad\u00e9 NE, Nassar CF (2003) Interplay between nitric oxide and vasoactive intestinal polypeptide in inducing fluid secretion in rat jejunum. J Physiol 550(3):863\u2013871","journal-title":"J Physiol"},{"key":"167_CR32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1365-2680.1999.00108.x","volume":"19","author":"F Mul\u00e9","year":"1999","unstructured":"Mul\u00e9 F, D\u2019Angelo S, Amato A, Contino I, Serio R (1999) Modulation by nitric oxide of spontaneous mechanical activity in rat proximal colon. J Auton Pharmacol 19:1\u20136","journal-title":"J Auton Pharmacol"},{"key":"167_CR33","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1474-8673.1992.tb00365.x","volume":"12","author":"F Mulea","year":"1992","unstructured":"Mulea F, Geraci A, Serio R, Postorino A (1992) On the peptidergic hypothesis for non-adrenergic non-cholinergic innervation in the rat duodenum. J Auton Pharmacol 12:81\u201388","journal-title":"J Auton Pharmacol"},{"key":"167_CR34","first-page":"G491","volume":"273","author":"F Mulea","year":"1997","unstructured":"Mulea F, Serio R (1997) Inhibition of mechanical activity by neurotensin in rat proximal colon: involvement of nitric oxide. Am J Physiol 273:G491\u2013G497","journal-title":"Am J Physiol"},{"key":"167_CR35","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/sj.bjp.0702363","volume":"12","author":"L Pluja","year":"1999","unstructured":"Pluja L, Fern\u00e1ndez E, Jim\u00e9nez M (1999) Neural modulation of the cyclic electrical and mechanical activity in the rat colonic circular muscle: putative role of ATP and NO. Br J Pharmacol 12:883\u2013892","journal-title":"Br J Pharmacol"},{"key":"167_CR36","doi-asserted-by":"crossref","first-page":"C299","DOI":"10.1152\/ajpcell.1993.265.1.C299","volume":"265","author":"BE Robertson","year":"1993","unstructured":"Robertson BE, Schubert R, Hescheler J, Nelson MT (1993) cGMP-dependent protein kinase activates Ca activated K channels in cerebral artery smooth muscle cells. Am J Physiol 265:C299\u2013C303","journal-title":"Am J Physiol"},{"key":"167_CR37","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1152\/jappl.2001.91.3.1438","volume":"91","author":"KM Sanders","year":"2001","unstructured":"Sanders KM (2001) Invited review: mechanism of calcium handling in smooth muscles. J Appl Physiol 91:1438\u20131449","journal-title":"J Appl Physiol"},{"key":"167_CR38","first-page":"G379","volume":"262","author":"KM Sanders","year":"1992","unstructured":"Sanders KM, Ward SM (1992) Nitric oxide as a mediator of nonadrenergic noncholinergic neurotransmission. Am J Physiol 262:G379\u2013G392","journal-title":"Am J Physiol"},{"key":"167_CR39","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1474-8673.1996.tb00421.x","volume":"16","author":"R Serio","year":"1996","unstructured":"Serio R, Mulea F, Postorino A, Vetri T, Bonvissuto F (1996) Apamin-sensitive and -insensitive components of inhibitory junction potentials in rat caecum: role of nitric oxide. J Auton Pharmacol 16:183\u2013189","journal-title":"J Auton Pharmacol"},{"key":"167_CR40","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/S1089-8603(02)00144-1","volume":"8","author":"R Serio","year":"2003","unstructured":"Serio R, Zizzo MG, Mule F (2003) Nitric oxide induces muscular relaxation via cyclic GMP-dependent and -independent mechanisms in the longitudinal muscle of the mouse duodenum. Nitric Oxide 8:48\u201352","journal-title":"Nitric Oxide"},{"issue":"4","key":"167_CR41","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1211\/0022357055740","volume":"57","author":"K Seya","year":"2005","unstructured":"Seya K, Furukawa K, Yoshida K, Narita R, Motomura S (2005) Nifedipine enhances cGMP production through the activation of soluble guanylyl cyclase in rat ventricular papillary muscle. J Pharm Pharmacol 57(4):511\u2013514","journal-title":"J Pharm Pharmacol"},{"issue":"4","key":"167_CR42","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1023\/A:1010760619615","volume":"46","author":"D Sifrim","year":"2001","unstructured":"Sifrim D, Lefebvre R (2001) Role of nitric oxide during swallow-induced esophageal shortening in cats. Dig Dis Sci 46(4):822\u2013830","journal-title":"Dig Dis Sci"},{"key":"167_CR43","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3109\/10715769309056511","volume":"19","author":"H Tamai","year":"1993","unstructured":"Tamai H, Gaginella TS (1993) Direct evidence for nitric oxide stimulation of electrolyte secretion in the rat colon. Free Radic Res Commun 19:229\u2013239","journal-title":"Free Radic Res Commun"},{"key":"167_CR44","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/S0024-3205(01)01198-5","volume":"69","author":"A Tanovic","year":"2001","unstructured":"Tanovic A, Jim\u00e9nez M, Fern\u00e1ndez E (2001) Actions of NO donors and endogenous nitrergic transmitter on the longitudinal muscle of rat ileum in vitro: mechanisms involved. Life Sci 69:1143\u20131154","journal-title":"Life Sci"},{"key":"167_CR45","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1254\/jjp.53.281","volume":"53","author":"N Toda","year":"1990","unstructured":"Toda N, Baba H, Okamura T (1990) Role of nitric oxide in non-adrenergic, non-cholinergic nerve mediated relaxation in dog duodenal longitudinal muscle strips. Jpn J Pharmacol 53:281\u2013284","journal-title":"Jpn J Pharmacol"},{"key":"167_CR46","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1046\/j.1365-2982.2003.00454.x","volume":"16","author":"K Crombruggen Van","year":"2004","unstructured":"Van Crombruggen K, Lefebvre RA (2004) Nitrergic\u2013purinergic interactions in rat distal colon motility. Neurogastroenterol Motil 16:81\u201398","journal-title":"Neurogastroenterol Motil"},{"key":"167_CR47","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/sj.bjp.0705918","volume":"143","author":"G Vanneste","year":"2004","unstructured":"Vanneste G, Robberecht P, Lefebvre RA (2004) Inhibitory pathways in the circular muscle of rat jejunum. Br J Pharmacol 143:107\u2013118","journal-title":"Br J Pharmacol"},{"key":"167_CR48","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1152\/ajpcell.1996.270.3.C832","volume":"270","author":"KT Wilson","year":"1996","unstructured":"Wilson KT, Vaandrager AB, De-Vente J, Musch MW, De-Jonge HR, Chang EB (1996) Production and localization of cGMP and PGE2 in nitroprusside-stimulated rat colonic ion transport. Am J Physiol 270:832\u2013840","journal-title":"Am J Physiol"},{"key":"167_CR49","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.1469-7793.2001.00133.x","volume":"536","author":"Y Zhang","year":"2001","unstructured":"Zhang Y, Paterson WG (2001) Nitric oxide contracts longitudinal smooth muscle of opossum oesophagus via excitation\u2013contraction coupling. J Physiol 536:133\u2013140","journal-title":"J Physiol"},{"issue":"7","key":"167_CR50","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.3748\/wjg.14.1077","volume":"14","author":"H Zhou","year":"2008","unstructured":"Zhou H, Kong DH, Pan QW, Wang HH (2008) Sources of calcium in agonist-induced contraction of rat distal colon smooth muscle in vitro DOI: dx.doi.org. World J Gastroenterol 14(7):1077\u20131083","journal-title":"World J Gastroenterol"}],"container-title":["Journal of Physiology and Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13105-012-0167-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13105-012-0167-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13105-012-0167-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T23:59:48Z","timestamp":1687391988000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s13105-012-0167-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,14]]},"references-count":50,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["167"],"URL":"https:\/\/doi.org\/10.1007\/s13105-012-0167-x","relation":{},"ISSN":["1138-7548","1877-8755"],"issn-type":[{"value":"1138-7548","type":"print"},{"value":"1877-8755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,14]]}}}