{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:05:57Z","timestamp":1789517157267,"version":"build-2803163510"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2016,3,21]],"date-time":"2016-03-21T00:00:00Z","timestamp":1458518400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation of China","doi-asserted-by":"crossref","award":["14JJ2079"],"award-info":[{"award-number":["14JJ2079"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Physiol Biochem"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1007\/s13105-016-0479-3","type":"journal-article","created":{"date-parts":[[2016,3,21]],"date-time":"2016-03-21T14:04:26Z","timestamp":1458569066000},"page":"303-313","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Kaempferol inhibits the production of ROS to modulate OPN\u2013\u03b1v\u03b23 integrin pathway in HUVECs"],"prefix":"10.1007","volume":"72","author":[{"given":"Hong-Bo","family":"Xiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-Yang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Kui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Feng","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,3,21]]},"reference":[{"key":"479_CR1","doi-asserted-by":"crossref","first-page":"e104","DOI":"10.1161\/ATVBAHA.112.300956","volume":"33","author":"N Anilkumar","year":"2013","unstructured":"Anilkumar N, San Jose G, Sawyer I, Santos CX, Sand C, Brewer AC, Warren D, Shah AM (2013) A 28-kDa splice variant of NADPH oxidase-4 is nuclear-localized and involved in redox signaling in vascular cells. Arterioscler Thromb Vasc Biol 33:e104\u2013112","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"479_CR2","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1002\/jcp.22356","volume":"226","author":"AS Antonov","year":"2011","unstructured":"Antonov AS, Antonova GN, Munn DH, Mivechi N, Lucas R, Catravas JD, Verin AD (2011) \u03b1V\u03b23 integrin regulates macrophage inflammatory responses via PI3 kinase\/Akt-dependent NF-\u03baB activation. J Cell Physiol 226:469\u2013476","journal-title":"J Cell Physiol"},{"key":"479_CR3","doi-asserted-by":"crossref","first-page":"28593","DOI":"10.1074\/jbc.M303445200","volume":"278","author":"R Das","year":"2003","unstructured":"Das R, Mahabeleshwar GH, Kundu GC (2003) Osteopontin stimulates cell motility and nuclear factor kappaB-mediated secretion of urokinase type plasminogen activator through phosphatidylinositol 3-kinase\/Akt signaling pathways in breast cancer cells. J Biol Chem 278:28593\u201328606","journal-title":"J Biol Chem"},{"key":"479_CR4","doi-asserted-by":"crossref","first-page":"5103","DOI":"10.1128\/MCB.00820-12","volume":"32","author":"KM Farjo","year":"2012","unstructured":"Farjo KM, Farjo RA, Halsey S, Moiseyev G, Ma JX (2012) Retinol-binding protein 4 induces inflammation in human endothelial cells by an NADPH oxidase- and nuclear factor kappa B-dependent and retinol-independent mechanism. Mol Cell Biol 32:5103\u20135115","journal-title":"Mol Cell Biol"},{"key":"479_CR5","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1097\/MED.0b013e3283391989","volume":"17","author":"KC Gilbert","year":"2010","unstructured":"Gilbert KC, Brown NJ (2010) Aldosterone and inflammation. Curr Opin Endocrinol Diabetes Obes 17:199\u2013204","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"479_CR6","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3945\/jn.111.150748","volume":"142","author":"JH Gong","year":"2012","unstructured":"Gong JH, Shin D, Han SY, Kim JL, Kang YH (2012) Kaempferol suppresses eosinophil infiltration and airway inflammation in airway epithelial cells and in mice with allergic asthma. J Nutr 142:47\u201356","journal-title":"J Nutr"},{"issue":"1","key":"479_CR7","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1073\/pnas.1210200110","volume":"110","author":"JE Goodwin","year":"2013","unstructured":"Goodwin JE, Feng Y, Velazquez H, Sessa WC (2013) Endothelial glucocorticoid receptor is required for protection against sepsis. Proc Natl Acad Sci U S A 110(1):306\u201311","journal-title":"Proc Natl Acad Sci U S A"},{"key":"479_CR8","doi-asserted-by":"crossref","first-page":"40955","DOI":"10.1074\/jbc.M106878200","volume":"276","author":"VH Guaiquil","year":"2001","unstructured":"Guaiquil VH, Vera JC, Golde DW (2001) Mechanism of vitamin C inhibition of cell death induced by oxidative stress in glutathione-depleted HL-60 cells. J Biol Chem 276:40955\u201340961","journal-title":"J Biol Chem"},{"key":"479_CR9","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1291\/hypres.31.363","volume":"31","author":"H Hayashi","year":"2008","unstructured":"Hayashi H, Kobara M, Abe M, Tanaka N, Gouda E, Toba H, Yamada H, Tatsumi T, Nakata T, Matsubara H (2008) Aldosterone nongenomically produces NADPH oxidase-dependent reactive oxygen species and induces myocyte apoptosis. Hypertens Res 31:363\u2013375","journal-title":"Hypertens Res"},{"key":"479_CR10","doi-asserted-by":"crossref","first-page":"3419","DOI":"10.1245\/s10434-007-9564-8","volume":"14","author":"M Higashiyama","year":"2007","unstructured":"Higashiyama M, Ito T, Tanaka E, Shimada Y (2007) Prognostic significance of osteopontin expression in human gastric carcinoma. Ann Surg Oncol 14:3419\u20133427","journal-title":"Ann Surg Oncol"},{"key":"479_CR11","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1111\/j.1524-475X.2007.00265.x","volume":"15","author":"S Ichioka","year":"2007","unstructured":"Ichioka S, Sekiya N, Shibata M, Nakatsuka T (2007) AlphaV beta3 (alphavbeta3) integrin inhibition reduces leukocyte-endothelium interaction in a pressure-induced reperfusion model. Wound Repair Regen 15:572\u2013576","journal-title":"Wound Repair Regen"},{"key":"479_CR12","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1161\/01.CIR.0000055739.13639.D7","volume":"107","author":"K Isoda","year":"2003","unstructured":"Isoda K, Kamezawa Y, Ayaori M, Kusuhara M, Tada N, Ohsuzu F (2003) Osteopontin transgenic mice fed a high-cholesterol diet develop early fatty-streak lesions. Circulation 107:679\u2013681","journal-title":"Circulation"},{"key":"479_CR13","doi-asserted-by":"crossref","first-page":"208","DOI":"10.2174\/187152809788680994","volume":"8","author":"P Johnson","year":"2009","unstructured":"Johnson P, Ruffell B (2009) CD44 and its role in inflammation and inflammatory diseases. Inflamm Allergy Drug Targets 8:208\u2013220","journal-title":"Inflamm Allergy Drug Targets"},{"key":"479_CR14","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s00011-011-0403-9","volume":"61","author":"TH Kim","year":"2012","unstructured":"Kim TH, Ku SK, Lee IC, Bae JS (2012) Anti-inflammatory effects of kaempferol-3-O-sophoroside in human endothelial cells. Inflamm Res 61:217\u2013224","journal-title":"Inflamm Res"},{"key":"479_CR15","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/2045-824X-3-27","volume":"23","author":"R Kumar","year":"2011","unstructured":"Kumar R, Harris-Hooker S, Kumar R, Sanford G (2011) Co-culture of retinal and endothelial cells results in the modulation of genes critical to retinal neovascularization. Vasc Cell 23:27","journal-title":"Vasc Cell"},{"key":"479_CR16","doi-asserted-by":"crossref","first-page":"10381","DOI":"10.1158\/0008-5472.CAN-10-1470","volume":"70","author":"V Kumar","year":"2010","unstructured":"Kumar V, Behera R, Lohite K, Karnik S, Kundu GC (2010) p38 kinase is crucial for osteopontin-induced furin expression that supports cervical cancer progression. Cancer Res 70:10381\u201310391","journal-title":"Cancer Res"},{"key":"479_CR17","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1097\/HJH.0b013e328330a963","volume":"27","author":"E Leibovitz","year":"2009","unstructured":"Leibovitz E, Ebrahimian T, Paradis P, Schiffrin EL (2009) Aldosterone induces arterial stiffness in absence of oxidative stress and endothelial dysfunction. J Hypertens 27:2192\u20132200","journal-title":"J Hypertens"},{"key":"479_CR18","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1093\/toxsci\/kfq279","volume":"118","author":"CH Li","year":"2010","unstructured":"Li CH, Cheng YW, Hsu YT, Hsu YJ, Liao PL, Kang JJ (2010) Benzo[a]pyrene inhibits angiogenic factors-induced alphavbeta3 integrin expression, neovasculogenesis, and angiogenesis in human umbilical vein endothelial cells. Toxicol Sci 118:544\u2013553","journal-title":"Toxicol Sci"},{"key":"479_CR19","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1161\/01.ATV.0000074878.29805.D0","volume":"23","author":"Y Matsui","year":"2003","unstructured":"Matsui Y, Rittling SR, Okamoto H, Inobe M, Jia N, Shimizu T, Akino M, Sugawara T, Morimoto J, Kimura C, Kon S, Denhardt D, Kitabatake A, Uede T (2003) Osteopontin deficiency attenuates atherosclerosis in female apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 23:1029\u20131034","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"479_CR20","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1161\/01.STR.0000016325.54374.93","volume":"33","author":"AM McNeill","year":"2002","unstructured":"McNeill AM, Zhang C, Stanczyk FZ, Duckles SP, Krause DN (2002) Estrogen increases endothelial nitric oxide synthase via estrogen receptors in rat cerebral blood vessels: effect preserved after concurrent treatment with medroxyprogesterone acetate or progesterone. Stroke 33:1685\u20131691","journal-title":"Stroke"},{"key":"479_CR21","doi-asserted-by":"crossref","first-page":"14487","DOI":"10.1074\/jbc.M207309200","volume":"278","author":"S Philip","year":"2003","unstructured":"Philip S, Kundu GC (2003) Osteopontin induces nuclear factor kappa B-mediated promatrix metalloproteinase-2 activation through I kappa B alpha \/IKK signaling pathways, and curcumin (diferulolylmethane) down-regulates these pathways. J Biol Chem 278:14487\u201314497","journal-title":"J Biol Chem"},{"key":"479_CR22","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1002\/jcp.22549","volume":"226","author":"P Poggio","year":"2011","unstructured":"Poggio P, Grau JB, Field BC, Sainger R, Seefried WF, Rizzolio F, Ferrari G (2011) Osteopontin controls endothelial cell migration in vitro and in excised human valvular tissue from patients with calcific aortic stenosis and controls. J Cell Physiol 226:2139\u20132149","journal-title":"J Cell Physiol"},{"key":"479_CR23","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/mc.20710","volume":"50","author":"N Queisser","year":"2011","unstructured":"Queisser N, Oteiza PI, Stopper H, Oli RG, Schupp N (2011) Aldosterone induces oxidative stress, oxidative DNA damage and NF-\u03baB-activation in kidney tubule cells. Mol Carcinog 50:123\u2013135","journal-title":"Mol Carcinog"},{"key":"479_CR24","doi-asserted-by":"crossref","first-page":"5379","DOI":"10.1073\/pnas.0601026103","volume":"A103","author":"M Quintero","year":"2006","unstructured":"Quintero M, Colombo SL, Godfrey A, Moncada S (2006) Mitochondria as signaling organelles in the vascular endothelium. Proc Natl Acad Sci U S A A103:5379\u20135384","journal-title":"Proc Natl Acad Sci U S A"},{"key":"479_CR25","doi-asserted-by":"crossref","first-page":"697972","DOI":"10.1155\/2013\/697972","volume":"2013","author":"A Schildberger","year":"2013","unstructured":"Schildberger A, Rossmanith E, Eichhorn T, Strassl K, Weber V (2013) Monocytes, peripheral blood mononuclear cells, and THP-1 cells exhibit different cytokine expression patterns following stimulation with lipopolysaccharide. Mediat Inflamm 2013:697972","journal-title":"Mediat Inflamm"},{"key":"479_CR26","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.niox.2012.06.006","volume":"27","author":"Y Steffen","year":"2012","unstructured":"Steffen Y, Vuillaume G, Stolle K, Roewer K, Lietz M, Schueller J, Lebrun S, Wallerath T (2012) Cigarette smoke and LDL cooperate in reducing nitric oxide bioavailability in endothelial cells via effects on both eNOS and NADPH oxidase. Nitric Oxide 27:176\u2013184","journal-title":"Nitric Oxide"},{"key":"479_CR27","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.bbrc.2005.08.056","volume":"336","author":"T Sugiyama","year":"2005","unstructured":"Sugiyama T, Yoshimoto T, Hirono Y, Suzuki N, Sakurada M, Tsuchiya K, Minami I, Iwashima F, Sakai H, Tateno T, Sato R, Hirata Y (2005) Aldosterone increases osteopontin gene expression in rat endothelial cells. Biochem Biophys Res Commun 336:163\u2013167","journal-title":"Biochem Biophys Res Commun"},{"key":"479_CR28","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1111\/j.1365-2362.2008.01977.x","volume":"38","author":"Y Talmor","year":"2008","unstructured":"Talmor Y, Bernheim J, Klein O, Green J, Rashid G (2008) Calcitriol blunts pro-atherosclerotic parameters through NFkappaB and p38 in vitro. Eur J Clin Invest 38:548\u2013554","journal-title":"Eur J Clin Invest"},{"key":"479_CR29","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1002\/hep.24701","volume":"55","author":"R Urtasun","year":"2012","unstructured":"Urtasun R, Lopategi A, George J, Leung TM, Lu Y, Wang X, Ge X, Fiel MI, Nieto N (2012) Osteopontin, an oxidant stress sensitive cytokine, up-regulates collagen-I via integrin \u03b1(V)\u03b2(3) engagement and PI3K\/pAkt\/NF\u03baB signaling. Hepatology 55:594\u2013608","journal-title":"Hepatology"},{"key":"479_CR30","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1042\/bj20020752","volume":"367","author":"S Wang","year":"2002","unstructured":"Wang S, Kotamraju S, Konorev E, Kalivendi S, Joseph J, Kalyanaraman B (2002) Activation of nuclear factor-kappaB during doxorubicin-induced apoptosis in endothelial cells and myocytes is pro-apoptotic: the role of hydrogen peroxide. Biochem J 367:729\u2013740","journal-title":"Biochem J"},{"key":"479_CR31","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1164\/rccm.201110-1859ED","volume":"185","author":"PA Ward","year":"2012","unstructured":"Ward PA (2012) Inflammation and \u03b1v\u03b23 integrin. Am J Respir Crit Care Med 185:5\u20136","journal-title":"Am J Respir Crit Care Med"},{"key":"479_CR32","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.taap.2011.09.024","volume":"257","author":"HB Xiao","year":"2011","unstructured":"Xiao HB, Lu XY, Sun ZL, Zhang HB (2011) Kaempferol regulates OPN-CD44 pathway to inhibit the atherogenesis of apolipoprotein E deficient mice. Toxicol Appl Pharmacol 257:405\u2013411","journal-title":"Toxicol Appl Pharmacol"},{"key":"479_CR33","doi-asserted-by":"crossref","first-page":"6507","DOI":"10.1128\/MCB.23.18.6507-6519.2003","volume":"23","author":"G Zhang","year":"2003","unstructured":"Zhang G, He B, Weber GF (2003) Growth factor signaling induces metastasis genes in transformed cells: molecular connection between Akt kinase and osteopontin in breast cancer. Mol Cell Biol 23:6507\u20136519","journal-title":"Mol Cell Biol"}],"container-title":["Journal of Physiology and Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13105-016-0479-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13105-016-0479-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13105-016-0479-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T16:40:25Z","timestamp":1589647225000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s13105-016-0479-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,21]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["479"],"URL":"https:\/\/doi.org\/10.1007\/s13105-016-0479-3","relation":{},"ISSN":["1138-7548","1877-8755"],"issn-type":[{"value":"1138-7548","type":"print"},{"value":"1877-8755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,21]]}}}