{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:21:40Z","timestamp":1783556500915,"version":"3.55.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2016,9,6]],"date-time":"2016-09-06T00:00:00Z","timestamp":1473120000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"University of KwaZulu-Natal, Durban, South Africa","award":["Not applicable"],"award-info":[{"award-number":["Not applicable"]}]},{"name":"National Research Foundation, Pretoria, South Africa","award":["Not applicable"],"award-info":[{"award-number":["Not applicable"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Physiol Biochem"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1007\/s13105-016-0517-1","type":"journal-article","created":{"date-parts":[[2016,9,5]],"date-time":"2016-09-05T23:34:00Z","timestamp":1473118440000},"page":"791-801","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Myo-inositol inhibits intestinal glucose absorption and promotes muscle glucose uptake: a dual approach study"],"prefix":"10.1007","volume":"72","author":[{"given":"Chika Ifeanyi","family":"Chukwuma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Auwal","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Shahidul","family":"Islam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,9,6]]},"reference":[{"key":"517_CR1","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1016\/j.fct.2010.06.010","volume":"48","author":"MM Algandaby","year":"2010","unstructured":"Algandaby MM, Alghamdi HA, Ashour OM, et al. (2010) Mechanisms of the antihyperglycemic activity of Retama raetam in streptozotocin-induced diabetic rats. Food Chem Toxicol 48:2448\u20132453","journal-title":"Food Chem Toxicol"},{"key":"517_CR2","first-page":"183","volume":"17","author":"SL Aronoff","year":"2004","unstructured":"Aronoff SL, Berkowitz K, Shreiner B, Want L (2004) Glucose metabolism and regulation: beyond insulin and glucagon diabetes. Spectr 17:183\u2013190","journal-title":"Spectr"},{"key":"517_CR3","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1093\/jn\/131.10.2782S","volume":"131","author":"DH Bessesen","year":"2001","unstructured":"Bessesen DH (2001) The role of carbohydrates in insulin resistance. J Nutr 131:2782\u20132786","journal-title":"J Nutr"},{"key":"517_CR4","doi-asserted-by":"crossref","first-page":"305","DOI":"10.3109\/17477160903497027","volume":"5","author":"RJ Brown","year":"2010","unstructured":"Brown RJ, De Banate MA, Rother KI (2010) Artificial sweeteners: a systematic review of metabolic effects in youth. Int J Pediatr Obes 5:305\u2013312","journal-title":"Int J Pediatr Obes"},{"key":"517_CR5","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1016\/S0960-894X(99)00348-0","volume":"9","author":"SK Chung","year":"1999","unstructured":"Chung SK, Kwon YU (1999) Practical synthesis of all inositol stereoisomers from myo-inositol. Bioorg Med Chem Lett 9:2135\u20132140","journal-title":"Bioorg Med Chem Lett"},{"key":"517_CR6","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1093\/ajcn\/33.9.1954","volume":"33","author":"RS Clements Jr","year":"1980","unstructured":"Clements RS Jr, Darnell B (1980) Myo-inositol content of common foods: development of a high-myo-inositol diet. Am J Clin Nutr 33:1954\u20131967","journal-title":"Am J Clin Nutr"},{"key":"517_CR7","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1271\/bbb.90963","volume":"74","author":"NT Dang","year":"2010","unstructured":"Dang NT, Mukai R, Yoshida K, Ashida H (2010) D-pinitol and myo-inositol stimulate translocation of glucose transporter 4 in skeletal muscle of C57BL\/6 mice. Biosci Biotechnol Biochem 74:1062\u20131067","journal-title":"Biosci Biotechnol Biochem"},{"key":"517_CR8","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1900\/RDS.2007.4.13","volume":"4","author":"GVS Dedoussis","year":"2007","unstructured":"Dedoussis GVS, Kaliora AC, Panagiotakos DB (2007) Genes, Diet and Type 2 Diabetes Mellitus: A Review. Rev Diab Stud 4:13\u201324","journal-title":"Rev Diab Stud"},{"key":"517_CR9","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.ejogrb.2015.09.024","volume":"195","author":"F Facchinetti","year":"2015","unstructured":"Facchinetti F, Bizzarri M, Benvenga S, et al. (2015) Results from the international consensus conference on myo-inositol and D-chiro-inositol in obstetrics and gynecology: the link between metabolic syndrome and PCOS. Eur J Obstet Gynecol Reprod Biol 195:72\u201376","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"517_CR10","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1007\/BF02233070","volume":"13","author":"AB French","year":"1968","unstructured":"French AB, Brown IF, Good CJ, McLeod GM (1968) Comparison of phenol red and polyethyleneglycol as non-absorbable markers for the study of intestinal absorption in humans. Am J Dig Dis 13:558\u2013564","journal-title":"Am J Dig Dis"},{"key":"517_CR11","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1097\/gme.0b013e3181e8e1b1","volume":"18","author":"D Giordano","year":"2011","unstructured":"Giordano D, Corrado F, Santamaria A, et al. (2011) Effects of myo-inositol supplementation in postmenopausal women with metabolic syndrome: a perspective, randomized, placebo-controlled study. Menopause 18:102\u2013104","journal-title":"Menopause"},{"key":"517_CR12","doi-asserted-by":"crossref","first-page":"9008","DOI":"10.3390\/molecules15129008","volume":"15","author":"Z Hassan","year":"2010","unstructured":"Hassan Z, Yam MF, Ahmad M, Yusof AP (2010) Anti-diabetic properties and mechanism of action of Gynuraprocumbens water extract in streptozotocin \u2013 induced diabetic rats. Molecules 15:9008\u20139025","journal-title":"Molecules"},{"key":"517_CR13","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1507\/endocrj.EJ13-0423","volume":"61","author":"D Heimark","year":"2014","unstructured":"Heimark D, McAllister J, Larner J (2014) Decreased myo-inositol to chiro-inositol (M\/ C) ratios and increased M\/C epimerase activity in PCOS theca cells demonstrate increased insulin sensitivity compared to controls. Endocr J 61:111\u2013117","journal-title":"Endocr J"},{"key":"517_CR14","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1002\/dme.1996.13.s6.16","volume":"13","author":"M Horowitz","year":"1996","unstructured":"Horowitz M, Wishart JM, Jones KL, Hebbard GS (1996) Gastric emptying in diabetes: an overview. Diabet Med 13:S16\u2013S22","journal-title":"Diabet Med"},{"key":"517_CR15","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s11745-003-1038-4","volume":"38","author":"FB Hu","year":"2003","unstructured":"Hu FB (2003) Sedentary lifestyle and risk of obesity and type 2 diabetes. Lipids 38:103\u2013108","journal-title":"Lipids"},{"key":"517_CR16","unstructured":"International Diabetes Federation (2015) IDF Diabetes Atlas. 7th edition"},{"key":"517_CR17","doi-asserted-by":"crossref","first-page":"7635","DOI":"10.3748\/wjg.v12.i47.7635","volume":"12","author":"MS Islam","year":"2006","unstructured":"Islam MS, Sakaguchi E (2006) Sorbitol-based osmotic diarrhea: possible causes and mechanism of prevention investigated in rats. World J Gastroenterol 12:7635\u20137641","journal-title":"World J Gastroenterol"},{"key":"517_CR18","doi-asserted-by":"crossref","unstructured":"Kunjara S, Wang DY, Greenbaum AL, McLean P, Kurtz A, Rademacher TW (1999) Inositol phosphoglycans in diabetes and obesity: urinary levels of IPG A-type and IPG P-type, and relationship to pathophysiological changes. Mol Genet Metab 68:488\u2013502","DOI":"10.1006\/mgme.1999.2936"},{"key":"517_CR19","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1079\/NRR200371","volume":"16","author":"G Livesey","year":"2003","unstructured":"Livesey G (2003) Health potential of polyols as sugar replacers, with emphasis on low glycaemic properties. Nutr Res Rev 16:163\u2013191","journal-title":"Nutr Res Rev"},{"key":"517_CR20","first-page":"167","volume-title":"Guide lines for adolescent nutrition service","author":"E Loghmani","year":"2005","unstructured":"Loghmani E (2005) Diabetes mellitus: type 1 and type 2. In: Stang J (ed) Guide lines for adolescent nutrition service. University of Minnesota, Minneapolis, pp. 167\u2013182"},{"key":"517_CR21","doi-asserted-by":"crossref","first-page":"196","DOI":"10.3177\/jnsv.54.196","volume":"54","author":"R Maeba","year":"2008","unstructured":"Maeba R, Hara H, Ishikawa H, et al. (2008) Myoinositol treatment increases serum plasmalogens and decreases small dense LDL, particularly in hyperlipidemic subjects with metabolic syndrome. J Nutr Sci Vitaminol (Tokyo) 54:196\u2013202","journal-title":"J Nutr Sci Vitaminol (Tokyo)"},{"key":"517_CR22","doi-asserted-by":"crossref","first-page":"18495","DOI":"10.1074\/jbc.M906994199","volume":"275","author":"J McLaurin","year":"2000","unstructured":"McLaurin J, Golomb R, Jurewicz A, Antel JP, Fraser PE (2000) Inositol stereoisomers stabilize on oligomeric aggregate of Alzheimer amyloid beta peptide and inhibit Abeta-induced toxicity. J Biol Chem 275:18495\u201318502","journal-title":"J Biol Chem"},{"key":"517_CR23","doi-asserted-by":"crossref","first-page":"33428","DOI":"10.1074\/jbc.M801781200","volume":"283","author":"P McLean","year":"2008","unstructured":"McLean P, Kunjara S, Greenbaum AL, et al. (2008) Reciprocal control of pyruvate dehydrogenase kinase and phosphatase by inositol phosphoglycans. Dynamic state set by \"push-pull\" system. J Biol Chem 283:33428\u201333436","journal-title":"J Biol Chem"},{"key":"517_CR24","first-page":"537","volume":"17","author":"M Minozzi","year":"2013","unstructured":"Minozzi M, Nordio M, Pajalich R (2013) The combined therapy myo-inositol plus D-chiro-inositol, in a physiological ratio, reduces the cardiovascular risk by improving the lipid profile in PCOS patients. Eur Rev Med Pharmacol Sci 17:537\u2013540","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"517_CR25","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1093\/jn\/137.6.1447","volume":"137","author":"J Montonen","year":"2007","unstructured":"Montonen J, J\u00e4rvinen R, Knekt P, Heli\u00f6vaara M, Reunanen A (2007) Consumption of sweetened beverages and intakes of fructose and glucose predict type 2 diabetes occurrence. J Nutr 137:1447\u20131454","journal-title":"J Nutr"},{"key":"517_CR26","first-page":"575","volume":"16","author":"M Nordio","year":"2012","unstructured":"Nordio M, Proietti E (2012) The combined therapy with myo-inositol and D-chiro-inositol reduces the risk of metabolic disease in PCOS overweight patients compared to myo-inositol supplementation alone. Eur Rev Med Pharmacol Sci 16:575\u2013581","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"517_CR27","doi-asserted-by":"crossref","first-page":"267","DOI":"10.4327\/jsnfs.50.267","volume":"50","author":"S Onomi","year":"1997","unstructured":"Onomi S, Katayama T (1997) Effects of dietary myo-inositol and phytic acid on hepatic lipids accumulation in rats fed on sucrose or orotic acid. J Jpn Soc Nutr Food Sci 50:267\u2013272","journal-title":"J Jpn Soc Nutr Food Sci"},{"key":"517_CR28","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/j.amjmed.2013.06.007","volume":"126","author":"RE Partley","year":"2013","unstructured":"Partley RE (2013) The early treatment of type 2 diabetes. Am J Med 126:S2\u2013S9","journal-title":"Am J Med"},{"key":"517_CR29","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1056\/NEJM199102143240705","volume":"324","author":"WT Phillips","year":"1991","unstructured":"Phillips WT, Schwartz JG, McMahan CA (1991) Rapid gastric emptying in patients with early non-insulin-dependent diabetes mellitus. N Engl J Med 324:130\u2013131","journal-title":"N Engl J Med"},{"key":"517_CR30","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1002\/(SICI)1096-9136(199802)15:2<120::AID-DIA529>3.0.CO;2-I","volume":"15","author":"L Ranganath","year":"1998","unstructured":"Ranganath L, Norris F, Morgan L, Wright J, Marks V (1998) Delayed gastric emptying occurs following acarbose administration and is a further mechanism for its anti-hyperglycaemic effect. Diabet Med 15:120\u2013124","journal-title":"Diabet Med"},{"key":"517_CR31","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1085\/jgp.50.5.1173","volume":"50","author":"AK Rider","year":"1967","unstructured":"Rider AK, Schedl HP, Nokes G, Shining S (1967) Small intestinal glucose transport. Proximal-distal kinetic gradients. J Gen Physiol 50:1173\u20131182","journal-title":"J Gen Physiol"},{"key":"517_CR32","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1093\/jn\/110.1.117","volume":"110","author":"G Riesenfeld","year":"1980","unstructured":"Riesenfeld G, Sklan D, Bar A, Eisner U, Hurwitz S (1980) Glucose absorption and starch digestion in the intestine of the chicken. J Nutr 110:117\u2013121","journal-title":"J Nutr"},{"key":"517_CR33","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1093\/jn\/114.12.2201","volume":"114","author":"E Salminen","year":"1984","unstructured":"Salminen E, Salminen S, Porkka L, Koivistoinen P (1984) The effects of xylitol on gastric emptying and secretion of gastric inhibitory polypeptide in the rat. J Nutr 114:2201\u20132203","journal-title":"J Nutr"},{"key":"517_CR34","doi-asserted-by":"crossref","first-page":"244","DOI":"10.2337\/diacare.13.3.244","volume":"13","author":"AR Saltiel","year":"1990","unstructured":"Saltiel AR (1990) Second messengers of insulin action. Diabetes Care 13:244\u2013256","journal-title":"Diabetes Care"},{"key":"517_CR35","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1093\/ajcn\/45.4.744","volume":"45","author":"RB Shafer","year":"1987","unstructured":"Shafer RB, Levine AS, Marlette JM, Morley JE (1987) Effects of xylitol on gastric emptying and food intake. Am J Clin Nutr 45:744\u2013747","journal-title":"Am J Clin Nutr"},{"key":"517_CR36","doi-asserted-by":"crossref","first-page":"E1596","DOI":"10.1210\/jc.2011-1251","volume":"96","author":"KL Stanhope","year":"2011","unstructured":"Stanhope KL, Bremer AA, Medici V, et al. (2011) Consumption of fructose and high fructose corn syrup increase postprandial triglycerides, LDL-cholesterol, and apolipoprotein-B in young men and women. J Clin Endocrinol Metab 96:E1596\u2013E1605","journal-title":"J Clin Endocrinol Metab"},{"key":"517_CR37","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1177\/1933719113518985","volume":"21","author":"V Unfer","year":"2014","unstructured":"Unfer V, Carlomagno G, Papaleo E, Vailati S, Candiani M, Baillargeon JP (2014) Hyperinsulinemia alters myoinositol to d-chiroinositol ratio in the follicular fluid of patients with PCOS. Reprod Sci 21:854\u2013858","journal-title":"Reprod Sci"},{"key":"517_CR38","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.2337\/diacare.25.9.1650","volume":"25","author":"M Uusitupa","year":"2002","unstructured":"Uusitupa M (2002) Lifestyles matter in the prevention of type 2 diabetes. Diabetes Care 25:1650\u20131651","journal-title":"Diabetes Care"},{"key":"517_CR39","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S1734-1140(12)70739-9","volume":"64","author":"RD Wilson","year":"2012","unstructured":"Wilson RD, Islam MS (2012) Fructose-fed streptozotocin-injected rat: an alternative model for type 2 diabetes. Pharmacol Rep 64:129\u2013139","journal-title":"Pharmacol Rep"},{"key":"517_CR40","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s10616-007-9107-y","volume":"55","author":"A Yap","year":"2007","unstructured":"Yap A, Nishiumi S, Yoshida K, Ashida H (2007) Rat L6 myotubes as an in vitro model system to study GLUT4-dependent glucose uptake stimulated by inositol derivatives. Cytotechnol 55:103\u2013108","journal-title":"Cytotechnol"}],"container-title":["Journal of Physiology and Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13105-016-0517-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13105-016-0517-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13105-016-0517-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T02:27:43Z","timestamp":1568341663000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s13105-016-0517-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,6]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["517"],"URL":"https:\/\/doi.org\/10.1007\/s13105-016-0517-1","relation":{},"ISSN":["1138-7548","1877-8755"],"issn-type":[{"value":"1138-7548","type":"print"},{"value":"1877-8755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,6]]}}}