{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:02:10Z","timestamp":1786982530632,"version":"build-2736575974"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2018,4,13]],"date-time":"2018-04-13T00:00:00Z","timestamp":1523577600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100004484","name":"Tehran University of Medical Sciences and Health Services","doi-asserted-by":"publisher","award":["91-03-30-19266"],"award-info":[{"award-number":["91-03-30-19266"]}],"id":[{"id":"10.13039\/501100004484","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Physiol Biochem"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1007\/s13105-018-0624-2","type":"journal-article","created":{"date-parts":[[2018,4,13]],"date-time":"2018-04-13T17:04:01Z","timestamp":1523639041000},"page":"369-379","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Evidence for the link between defective autophagy and inflammation in peripheral blood mononuclear cells of type 2 diabetic patients"],"prefix":"10.1007","volume":"74","author":[{"given":"Samira","family":"Alizadeh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Mazloom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asie","family":"Sadeghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solaleh","family":"Emamgholipour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abolfazl","family":"Golestani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farshid","family":"Noorbakhsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohsen","family":"Khoshniatnikoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1835-2883","authenticated-orcid":false,"given":"Reza","family":"Meshkani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,4,13]]},"reference":[{"key":"624_CR1","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1002\/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S","volume":"15","author":"KG Alberti","year":"1998","unstructured":"Alberti KG, Zimmet PZ (1998) Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabetic medicine: a journal of the British Diabetic Association 15:539\u2013553. \n                    https:\/\/doi.org\/10.1002\/(sici)1096-9136(199807)15:7<539::aid-dia668>3.0.co;2-s","journal-title":"Diabetic medicine: a journal of the British Diabetic Association"},{"key":"624_CR2","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1007\/s10875-007-9164-1","volume":"28","author":"KI Alexandraki","year":"2008","unstructured":"Alexandraki KI, Piperi C, Ziakas PD, Apostolopoulos NV, Makrilakis K, Syriou V, Diamanti-Kandarakis E, Kaltsas G, Kalofoutis A (2008) Cytokine secretion in long-standing diabetes mellitus type 1 and 2: associations with low-grade systemic inflammation. J Clin Immunol 28:314\u2013321. \n                    https:\/\/doi.org\/10.1007\/s10875-007-9164-1","journal-title":"J Clin Immunol"},{"key":"624_CR3","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1089\/dna.2014.2755","volume":"34","author":"AD Barlow","year":"2015","unstructured":"Barlow AD, Thomas DC (2015) Autophagy in diabetes: beta-cell dysfunction, insulin resistance, and complications. DNA Cell Biol 34:252\u2013260. \n                    https:\/\/doi.org\/10.1089\/dna.2014.2755","journal-title":"DNA Cell Biol"},{"key":"624_CR4","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1007\/s00467-009-1310-y","volume":"25","author":"J Bohensky","year":"2010","unstructured":"Bohensky J, Leshinsky S, Srinivas V, Shapiro IM (2010) Chondrocyte autophagy is stimulated by HIF-1 dependent AMPK activation and mTOR suppression. Pediatr Nephrol 25:633\u2013642. \n                    https:\/\/doi.org\/10.1007\/s00467-009-1310-y","journal-title":"Pediatr Nephrol"},{"key":"624_CR5","doi-asserted-by":"publisher","first-page":"6926","DOI":"10.1523\/JNEUROSCI.0800-08.2008","volume":"28","author":"B Boland","year":"2008","unstructured":"Boland B, Kumar A, Lee S, Platt FM, Wegiel J, Yu WH, Nixon RA (2008) Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease. The Journal of neuroscience: the official journal of the Society for Neuroscience 28:6926\u20136937. \n                    https:\/\/doi.org\/10.1523\/jneurosci.0800-08.2008","journal-title":"The Journal of neuroscience: the official journal of the Society for Neuroscience"},{"key":"624_CR6","doi-asserted-by":"publisher","first-page":"98","DOI":"10.18632\/aging.100431","volume":"4","author":"D Cai","year":"2012","unstructured":"Cai D, Liu T (2012) Inflammatory cause of metabolic syndrome via brain stress and NF-kappaB. Aging 4:98\u2013115. \n                    https:\/\/doi.org\/10.18632\/aging.100431","journal-title":"Aging"},{"key":"624_CR7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018666","volume":"6","author":"TS Plantinga","year":"2011","unstructured":"Crisan TO, Plantinga TS, van de Veerdonk FL, Farcas MF, Stoffels M, Kullberg BJ, van der Meer JW, Joosten LA, Netea MG (2011) Inflammasome-independent modulation of cytokine response by autophagy in human cells. PLoS One 6:e18666. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0018666","journal-title":"PLoS One"},{"key":"624_CR8","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20150017","volume":"35","author":"H-P Deng","year":"2015","unstructured":"Deng H-P, Chai J-K, Shen C-A, Zhang X-B, Ma L, Sun T-J, Hu Q-G, Chi Y-F, Dong N (2015) Insulin down-regulates the expression of ubiquitin E3 ligases partially by inhibiting the activity and expression of AMP-activated protein kinase in L6 myotubes. Biosci Rep 35:e00242. \n                    https:\/\/doi.org\/10.1042\/BSR20150017","journal-title":"Biosci Rep"},{"key":"624_CR9","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.semcdb.2014.08.006","volume":"36","author":"EA Dunlop","year":"2014","unstructured":"Dunlop EA, Tee AR (2014) mTOR and autophagy: a dynamic relationship governed by nutrients and energy. Semin Cell Dev Biol 36:121\u2013129. \n                    https:\/\/doi.org\/10.1016\/j.semcdb.2014.08.006","journal-title":"Semin Cell Dev Biol"},{"key":"624_CR10","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1016\/j.bbamcr.2008.07.014","volume":"1793","author":"EL Eskelinen","year":"2009","unstructured":"Eskelinen EL, Saftig P (2009) Autophagy: a lysosomal degradation pathway with a central role in health and disease. Biochim Biophys Acta 1793:664\u2013673. \n                    https:\/\/doi.org\/10.1016\/j.bbamcr.2008.07.014","journal-title":"Biochim Biophys Acta"},{"key":"624_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jdiacomp.2008.07.001","volume":"24","author":"M Gacka","year":"2010","unstructured":"Gacka M, Dobosz T, Szymaniec S, Bednarska-Chabowska D, Adamiec R, Sadakierska-Chudy A (2010) Proinflammatory and atherogenic activity of monocytes in type 2 diabetes. J Diabetes Complicat 24:1\u20138. \n                    https:\/\/doi.org\/10.1016\/j.jdiacomp.2008.07.001","journal-title":"J Diabetes Complicat"},{"key":"624_CR12","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.cyto.2011.08.022","volume":"56","author":"J Harris","year":"2011","unstructured":"Harris J (2011) Autophagy and cytokines. Cytokine 56:140\u2013144. \n                    https:\/\/doi.org\/10.1016\/j.cyto.2011.08.022","journal-title":"Cytokine"},{"key":"624_CR13","doi-asserted-by":"publisher","first-page":"9587","DOI":"10.1074\/jbc.M110.202911","volume":"286","author":"J Harris","year":"2011","unstructured":"Harris J, Hartman M, Roche C, Zeng SG, O'Shea A, Sharp FA, Lambe EM, Creagh EM, Golenbock DT, Tschopp J, Kornfeld H, Fitzgerald KA, Lavelle EC (2011) Autophagy controls IL-1beta secretion by targeting pro-IL-1beta for degradation. J Biol Chem 286:9587\u20139597. \n                    https:\/\/doi.org\/10.1074\/jbc.M110.202911","journal-title":"J Biol Chem"},{"key":"624_CR14","doi-asserted-by":"publisher","first-page":"577","DOI":"10.4161\/auto.18980","volume":"8","author":"S Kobayashi","year":"2012","unstructured":"Kobayashi S, Xu X, Chen K, Liang Q (2012) Suppression of autophagy is protective in high glucose-induced cardiomyocyte injury. Autophagy 8:577\u2013592. \n                    https:\/\/doi.org\/10.4161\/auto.18980","journal-title":"Autophagy"},{"key":"624_CR15","doi-asserted-by":"publisher","first-page":"2087","DOI":"10.1007\/s00125-015-3654-0","volume":"58","author":"R Kruse","year":"2015","unstructured":"Kruse R, Vind BF, Petersson SJ, Kristensen JM, Hojlund K (2015) Markers of autophagy are adapted to hyperglycaemia in skeletal muscle in type 2 diabetes. Diabetologia 58:2087\u20132095. \n                    https:\/\/doi.org\/10.1007\/s00125-015-3654-0","journal-title":"Diabetologia"},{"key":"624_CR16","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1016\/j.cell.2007.05.058","volume":"130","author":"DF Lee","year":"2007","unstructured":"Lee DF, Kuo HP, Chen CT, Hsu JM, Chou CK, Wei Y, Sun HL, Li LY, Ping B, Huang WC, He X, Hung JY, Lai CC, Ding Q, Su JL, Yang JY, Sahin AA, Hortobagyi GN, Tsai FJ, Tsai CH, Hung MC (2007) IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway. Cell 130:440\u2013455. \n                    https:\/\/doi.org\/10.1016\/j.cell.2007.05.058","journal-title":"Cell"},{"key":"624_CR17","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.4049\/jimmunol.1001954","volume":"186","author":"HM Lee","year":"2011","unstructured":"Lee HM, Shin DM, Yuk JM, Shi G, Choi DK, Lee SH, Huang SM, Kim JM, Kim CD, Lee JH, Jo EK (2011) Autophagy negatively regulates keratinocyte inflammatory responses via scaffolding protein p62\/SQSTM1. J Immunol (Baltimore, Md: 1950) 186:1248\u20131258. \n                    https:\/\/doi.org\/10.4049\/jimmunol.1001954","journal-title":"J Immunol (Baltimore, Md: 1950)"},{"key":"624_CR18","doi-asserted-by":"publisher","first-page":"31484","DOI":"10.1074\/jbc.M109.033936","volume":"284","author":"HY Liu","year":"2009","unstructured":"Liu HY, Han J, Cao SY, Hong T, Zhuo D, Shi J, Liu Z, Cao W (2009) Hepatic autophagy is suppressed in the presence of insulin resistance and hyperinsulinemia: inhibition of FoxO1-dependent expression of key autophagy genes by insulin. J Biol Chem 284:31484\u201331492. \n                    https:\/\/doi.org\/10.1074\/jbc.M109.033936","journal-title":"J Biol Chem"},{"key":"624_CR19","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) method. Methods (San Diego, Calif) 25:402\u2013408. \n                    https:\/\/doi.org\/10.1006\/meth.2001.1262","journal-title":"Methods (San Diego, Calif)"},{"key":"624_CR20","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1007\/s00125-009-1347-2","volume":"52","author":"M Masini","year":"2009","unstructured":"Masini M, Bugliani M, Lupi R, del Guerra S, Boggi U, Filipponi F, Marselli L, Masiello P, Marchetti P (2009) Autophagy in human type 2 diabetes pancreatic beta cells. Diabetologia 52:1083\u20131086. \n                    https:\/\/doi.org\/10.1007\/s00125-009-1347-2","journal-title":"Diabetologia"},{"key":"624_CR21","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1007\/s40139-013-0028-5","volume":"1","author":"NC McKnight","year":"2013","unstructured":"McKnight NC, Zhenyu Y (2013) Beclin 1, an essential component and master regulator of PI3K-III in health and disease. Current pathobiology reports 1:231\u2013238. \n                    https:\/\/doi.org\/10.1007\/s40139-013-0028-5","journal-title":"Current pathobiology reports"},{"key":"624_CR22","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/j.mam.2006.08.002","volume":"27","author":"AJ Meijer","year":"2006","unstructured":"Meijer AJ, Codogno P (2006) Signalling and autophagy regulation in health, aging and disease. Mol Asp Med 27:411\u2013425. \n                    https:\/\/doi.org\/10.1016\/j.mam.2006.08.002","journal-title":"Mol Asp Med"},{"key":"624_CR23","doi-asserted-by":"publisher","first-page":"32324","DOI":"10.1074\/jbc.M111.254417","volume":"286","author":"Q Meng","year":"2011","unstructured":"Meng Q, Cai D (2011) Defective hypothalamic autophagy directs the central pathogenesis of obesity via the IkappaB kinase beta (IKKbeta)\/NF-kappaB pathway. J Biol Chem 286:32324\u201332332. \n                    https:\/\/doi.org\/10.1074\/jbc.M111.254417","journal-title":"J Biol Chem"},{"key":"624_CR24","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1016\/j.clinbiochem.2009.05.018","volume":"42","author":"R Meshkani","year":"2009","unstructured":"Meshkani R, Adeli K (2009) Hepatic insulin resistance, metabolic syndrome and cardiovascular disease. Clin Biochem 42:1331\u20131346. \n                    https:\/\/doi.org\/10.1016\/j.clinbiochem.2009.05.018","journal-title":"Clin Biochem"},{"key":"624_CR25","doi-asserted-by":"publisher","first-page":"542","DOI":"10.4161\/auto.4600","volume":"3","author":"N Mizushima","year":"2007","unstructured":"Mizushima N, Yoshimori T (2007) How to interpret LC3 immunoblotting. Autophagy 3:542\u2013545","journal-title":"Autophagy"},{"key":"624_CR26","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.cell.2010.01.028","volume":"140","author":"N Mizushima","year":"2010","unstructured":"Mizushima N, Yoshimori T, Levine B (2010) Methods in mammalian autophagy research. Cell 140:313\u2013326. \n                    https:\/\/doi.org\/10.1016\/j.cell.2010.01.028","journal-title":"Cell"},{"key":"624_CR27","doi-asserted-by":"publisher","first-page":"372","DOI":"10.3390\/cells1030372","volume":"1","author":"F Moruno","year":"2012","unstructured":"Moruno F, Perez-Jimenez E, Knecht E (2012) Regulation of autophagy by glucose in mammalian cells. Cell 1:372\u2013395. \n                    https:\/\/doi.org\/10.3390\/cells1030372","journal-title":"Cell"},{"key":"624_CR28","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1100\/tsw.2006.179","volume":"6","author":"JF Navarro","year":"2006","unstructured":"Navarro JF, Mora C (2006) Diabetes, inflammation, proinflammatory cytokines, and diabetic nephropathy. TheScientificWorldJOURNAL 6:908\u2013917. \n                    https:\/\/doi.org\/10.1100\/tsw.2006.179","journal-title":"TheScientificWorldJOURNAL"},{"key":"624_CR29","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1093\/ndt\/gfm674","volume":"23","author":"JF Navarro","year":"2008","unstructured":"Navarro JF, Mora C, Gomez M, Muros M, Lopez-Aguilar C, Garcia J (2008) Influence of renal involvement on peripheral blood mononuclear cell expression behaviour of tumour necrosis factor-alpha and interleukin-6 in type 2 diabetic patients. Nephrol Dial Transplant 23:919\u2013926. \n                    https:\/\/doi.org\/10.1093\/ndt\/gfm674","journal-title":"Nephrol Dial Transplant"},{"key":"624_CR30","doi-asserted-by":"publisher","first-page":"235","DOI":"10.2119\/molmed.2010.00023","volume":"16","author":"A Ost","year":"2010","unstructured":"Ost A, Svensson K, Ruishalme I, Brannmark C, Franck N, Krook H, Sandstrom P, Kjolhede P, Stralfors P (2010) Attenuated mTOR signaling and enhanced autophagy in adipocytes from obese patients with type 2 diabetes. Mol Med (Cambridge, Mass) 16:235\u2013246. \n                    https:\/\/doi.org\/10.2119\/molmed.2010.00023","journal-title":"Mol Med (Cambridge, Mass)"},{"key":"624_CR31","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/j.coph.2012.01.017","volume":"12","author":"TS Plantinga","year":"2012","unstructured":"Plantinga TS, Joosten LA, van der Meer JW, Netea MG (2012) Modulation of inflammation by autophagy: consequences for Crohn's disease. Curr Opin Pharmacol 12:497\u2013502. \n                    https:\/\/doi.org\/10.1016\/j.coph.2012.01.017","journal-title":"Curr Opin Pharmacol"},{"key":"624_CR32","doi-asserted-by":"publisher","DOI":"10.1186\/s40169-017-0154-5","volume":"6","author":"M Qian","year":"2017","unstructured":"Qian M, Fang X, Wang X (2017) Autophagy and inflammation. Clin Transl Med 6:24. \n                    https:\/\/doi.org\/10.1186\/s40169-017-0154-5","journal-title":"Clin Transl Med"},{"key":"624_CR33","doi-asserted-by":"publisher","first-page":"510","DOI":"10.4161\/auto.5724","volume":"4","author":"P Saftig","year":"2008","unstructured":"Saftig P, Beertsen W, Eskelinen EL (2008) LAMP-2: a control step for phagosome and autophagosome maturation. Autophagy 4:510\u2013512","journal-title":"Autophagy"},{"key":"624_CR34","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1038\/nature07383","volume":"456","author":"T Saitoh","year":"2008","unstructured":"Saitoh T, Fujita N, Jang MH, Uematsu S, Yang BG, Satoh T, Omori H, Noda T, Yamamoto N, Komatsu M, Tanaka K, Kawai T, Tsujimura T, Takeuchi O, Yoshimori T, Akira S (2008) Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature 456:264\u2013268. \n                    https:\/\/doi.org\/10.1038\/nature07383","journal-title":"Nature"},{"key":"624_CR35","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1016\/j.crohns.2012.08.009","volume":"7","author":"C Strisciuglio","year":"2013","unstructured":"Strisciuglio C, Duijvestein M, Verhaar AP, Vos AC, van den Brink GR, Hommes DW, Wildenberg ME (2013) Impaired autophagy leads to abnormal dendritic cell-epithelial cell interactions. Journal of Crohn's & colitis 7:534\u2013541. \n                    https:\/\/doi.org\/10.1016\/j.crohns.2012.08.009","journal-title":"Journal of Crohn's & colitis"},{"key":"624_CR36","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.bbadis.2008.10.016","volume":"1792","author":"V Todde","year":"2009","unstructured":"Todde V, Veenhuis M, van der Klei IJ (2009) Autophagy: principles and significance in health and disease. Biochim Biophys Acta 1792:3\u201313. \n                    https:\/\/doi.org\/10.1016\/j.bbadis.2008.10.016","journal-title":"Biochim Biophys Acta"},{"key":"624_CR37","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1055\/s-2007-990288","volume":"39","author":"PC Tsiotra","year":"2007","unstructured":"Tsiotra PC, Tsigos C, Yfanti E, Anastasiou E, Vikentiou M, Psarra K, Papasteriades C, Raptis SA (2007) Visfatin, TNF-alpha and IL-6 mRNA expression is increased in mononuclear cells from type 2 diabetic women. Horm Metab Res 39:758\u2013763. \n                    https:\/\/doi.org\/10.1055\/s-2007-990288","journal-title":"Horm Metab Res"},{"key":"624_CR38","doi-asserted-by":"publisher","first-page":"e94496","DOI":"10.1371\/journal.pone.0094496","volume":"9","author":"S Xie","year":"2014","unstructured":"Xie S, Chen M, Yan B, He X, Chen X, Li D (2014) Identification of a role for the PI3K\/AKT\/mTOR signaling pathway in innate immune cells. PLoS One 9:e94496","journal-title":"PLoS One"},{"key":"624_CR39","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.ceb.2009.11.014","volume":"22","author":"Z Yang","year":"2010","unstructured":"Yang Z, Klionsky DJ (2010) Mammalian autophagy: core molecular machinery and signaling regulation. Curr Opin Cell Biol 22:124\u2013131. \n                    https:\/\/doi.org\/10.1016\/j.ceb.2009.11.014","journal-title":"Curr Opin Cell Biol"},{"key":"624_CR40","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1002\/jcp.24525","volume":"229","author":"H Yang","year":"2014","unstructured":"Yang H, Wang X, Zhang Y, Liu H, Liao J, Shao K, Chu Y, Liu G (2014) Modulation of TSC-mTOR signaling on immune cells in immunity and autoimmunity. J Cell Physiol 229:17\u201326. \n                    https:\/\/doi.org\/10.1002\/jcp.24426","journal-title":"J Cell Physiol"},{"key":"624_CR41","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/j.bbrc.2011.11.114","volume":"417","author":"T Yoshizaki","year":"2012","unstructured":"Yoshizaki T, Kusunoki C, Kondo M, Yasuda M, Kume S, Morino K, Sekine O, Ugi S, Uzu T, Nishio Y, Kashiwagi A, Maegawa H (2012) Autophagy regulates inflammation in adipocytes. Biochem Biophys Res Commun 417:352\u2013357. \n                    https:\/\/doi.org\/10.1016\/j.bbrc.2011.11.114","journal-title":"Biochem Biophys Res Commun"},{"key":"624_CR42","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1007\/s001250051188","volume":"42","author":"PZ Zimmet","year":"1999","unstructured":"Zimmet PZ (1999) Diabetes epidemiology as a tool to trigger diabetes research and care. Diabetologia 42:499\u2013518. \n                    https:\/\/doi.org\/10.1007\/s001250051188","journal-title":"Diabetologia"}],"container-title":["Journal of Physiology and Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13105-018-0624-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13105-018-0624-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13105-018-0624-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T19:25:39Z","timestamp":1555097139000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s13105-018-0624-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,13]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["624"],"URL":"https:\/\/doi.org\/10.1007\/s13105-018-0624-2","relation":{},"ISSN":["1138-7548","1877-8755"],"issn-type":[{"value":"1138-7548","type":"print"},{"value":"1877-8755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,13]]},"assertion":[{"value":"1 January 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 March 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 April 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Nothing to declare","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}