{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T23:19:32Z","timestamp":1778887172147,"version":"3.51.4"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,9,17]],"date-time":"2018-09-17T00:00:00Z","timestamp":1537142400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"the Natural Science Foundation of Shannxi","award":["2015JM8431"],"award-info":[{"award-number":["2015JM8431"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Physiol Biochem"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1007\/s13105-018-0648-7","type":"journal-article","created":{"date-parts":[[2018,9,17]],"date-time":"2018-09-17T01:55:46Z","timestamp":1537149346000},"page":"39-51","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Effects of resveratrol on regulation on UCP2 and cardiac function in diabetic rats"],"prefix":"10.1007","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4646-7920","authenticated-orcid":false,"given":"Jiayu","family":"Diao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengjie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,9,17]]},"reference":[{"key":"648_CR1","doi-asserted-by":"publisher","first-page":"1891","DOI":"10.1016\/j.jacc.2009.07.031","volume":"54","author":"EJ Anderson","year":"2009","unstructured":"Anderson EJ, Kypson AP, Rodriguez E, Anderson CA, Lehr EJ, Neufer PD (2009) Substrate-specific derangements in mitochondrial metabolism and redox balance in the atrium of the type 2 diabetic human heart. J Am Coll Cardiol 54:1891\u20131898. \n                    https:\/\/doi.org\/10.1016\/j.jacc.2009.07.031","journal-title":"J Am Coll Cardiol"},{"key":"648_CR2","doi-asserted-by":"publisher","first-page":"1454","DOI":"10.1002\/oby.21523","volume":"24","author":"MA Arzola-Paniagua","year":"2016","unstructured":"Arzola-Paniagua MA, Garcia-Salgado Lopez ER, Calvo-Vargas CG, Guevara-Cruz M (2016) Efficacy of an orlistat-resveratrol combination for weight loss in subjects with obesity: a randomized controlled trial. Obesity (Silver Spring) 24:1454\u20131463. \n                    https:\/\/doi.org\/10.1002\/oby.21523","journal-title":"Obesity (Silver Spring)"},{"key":"648_CR3","doi-asserted-by":"publisher","DOI":"10.3390\/nu8050250","volume-title":"Nutrients","author":"D Bonnefont-Rousselot","year":"2016","unstructured":"Bonnefont-Rousselot D (2016) Resveratrol and cardiovascular diseases. In: Nutrients. \n                    https:\/\/doi.org\/10.3390\/nu8050250"},{"key":"648_CR4","doi-asserted-by":"publisher","first-page":"1951","DOI":"10.2174\/1568026616666160204121431","volume":"16","author":"N Braidy","year":"2016","unstructured":"Braidy N, Jugder BE, Poljak A, Jayasena T, Mansour H, Nabavi SM, Sachdev P, Grant R (2016) Resveratrol as a potential therapeutic candidate for the treatment and management of Alzheimer's disease. Curr Top Med Chem 16:1951\u20131960","journal-title":"Curr Top Med Chem"},{"key":"648_CR5","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1016\/j.freeradbiomed.2004.05.034","volume":"37","author":"MD Brand","year":"2004","unstructured":"Brand MD, Affourtit C, Esteves TC, Green K, Lambert AJ, Miwa S, Pakay JL, Parker N (2004) Mitochondrial superoxide: production, biological effects, and activation of uncoupling proteins. Free Radic Biol Med 37:755\u2013767. \n                    https:\/\/doi.org\/10.1016\/j.freeradbiomed.2004.05.034","journal-title":"Free Radic Biol Med"},{"key":"648_CR6","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.dld.2014.11.015","volume":"47","author":"S Chen","year":"2015","unstructured":"Chen S, Zhao X, Ran L, Wan J, Wang X, Qin Y, Shu F, Gao Y, Yuan L, Zhang Q, Mi M (2015) Resveratrol improves insulin resistance, glucose and lipid metabolism in patients with non-alcoholic fatty liver disease: a randomized controlled trial. Dig Liver Dis 47:226\u2013232. \n                    https:\/\/doi.org\/10.1016\/j.dld.2014.11.015","journal-title":"Dig Liver Dis"},{"key":"648_CR7","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1152\/ajpheart.00368.2009","volume":"297","author":"A Csiszar","year":"2009","unstructured":"Csiszar A, Labinskyy N, Pinto JT, Ballabh P, Zhang H, Losonzy G, Pearson K, de Cabo R, Pacher P, Zhang C, Unqvari Z (2009) Resveratrol induces mitochondrial biogenesis in endothelial cells. Am J Physiol Heart Circ Physiol 297:13\u201320. \n                    https:\/\/doi.org\/10.1152\/ajpheart.00368.2009","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"648_CR8","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1111\/j.1748-1716.2008.01936.x","volume":"195","author":"A Daniels","year":"2009","unstructured":"Daniels A, Van Bilsen M, Goldschmeding R, van der Vusse GJ, van Nieuwenhovern FA (2009) Connective tissue growth factor and cardiac fibrosis. Acta Physiol (Oxford) 195:321\u2013338. \n                    https:\/\/doi.org\/10.1111\/j.1748-1716.2008.01936.x","journal-title":"Acta Physiol (Oxford)"},{"key":"648_CR9","doi-asserted-by":"publisher","first-page":"2271","DOI":"10.1161\/01.CIR.101.19.2271","volume":"101","author":"RB Devereux","year":"2000","unstructured":"Devereux RB, Roman MJ, Paranicas M, O'Grady MJ, Lee ET, Welty TK, Fabsitz RR, Robbins D, Rhoades ER, Howard BV (2000) Impact of diabetes on cardiac structure and function: the strong heart study. Circulation 101:2271\u20132276","journal-title":"Circulation"},{"key":"648_CR10","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1002\/mnfr.201200067","volume":"56","author":"GM Do","year":"2012","unstructured":"Do GM, Jung UJ, Park HJ, Kwon EY, Jeon SM, McGregor RA, Choi MS (2012) Resveratrol ameliorates diabetes-related metabolic changes via activation of AMP-activated protein kinase and its downstream targets in db\/db mice. Mol Nutr Food Res 56:1282\u20131291. \n                    https:\/\/doi.org\/10.1002\/mnfr.201200067","journal-title":"Mol Nutr Food Res"},{"key":"648_CR11","first-page":"565","volume":"7","author":"S Dong","year":"2014","unstructured":"Dong S, Ma W, Hao B, Hu F, Yan L, Yan X, Wang Y, Chen Z, Wang Z (2014) microRNA-21 promotes cardiac fibrosis and development of heart failure with preserved left ventricular ejection fraction by up-regulating Bcl-2. Int J Clin Exp Pathol 7:565\u2013574","journal-title":"Int J Clin Exp Pathol"},{"key":"648_CR12","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1161\/CIRCULATIONAHA.106.662296","volume":"115","author":"JG Duncan","year":"2007","unstructured":"Duncan JG, Fong JL, Medeiros DM, Finck BN, Kelly DP (2007) Insulin-resistant heart exhibits a mitochondrial biogenic response driven by the peroxisome proliferator-activated receptor-alpha\/PGC-1alpha gene regulatory pathway. Circulation 115:909\u2013917. \n                    https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.106.662296","journal-title":"Circulation"},{"key":"648_CR13","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1253\/circj.CJ-13-0321","volume":"77","author":"JW Elrod","year":"2013","unstructured":"Elrod JW, Molkentin JD (2013) Physiologic functions of cyclophilin D and the mitochondrial permeability transition pore. Circ J 77:1111\u20131122","journal-title":"Circ J"},{"key":"648_CR14","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/S0735-1097(02)02869-3","volume":"41","author":"ZY Fang","year":"2003","unstructured":"Fang ZY, Yuda S, Anderson V, Short L, Case C, Marwick TH (2003) Echocardiographic detection of early diabetic myocardial disease. J Am Coll Cardiol 41:611\u2013617","journal-title":"J Am Coll Cardiol"},{"key":"648_CR15","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1210\/er.2003-0012","volume":"25","author":"ZY Fang","year":"2004","unstructured":"Fang ZY, Prins JB, Marwick TH (2004) Diabetic cardiomyopathy: evidence, mechanisms, and therapeutic implications. Endocr Rev 25:543\u2013567. \n                    https:\/\/doi.org\/10.1210\/er.2003-0012","journal-title":"Endocr Rev"},{"key":"648_CR16","doi-asserted-by":"publisher","unstructured":"Ferraz Da Costa DC, Fialho E, Silva JL (2017) Cancer chemoprevention by resveratrol: the p53 tumor suppressor protein as a promising molecular target. Molecules. \n                    https:\/\/doi.org\/10.3390\/molecules22061014","DOI":"10.3390\/molecules22061014"},{"key":"648_CR17","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1038\/labinvest.3780057","volume":"80","author":"F Fiordaliso","year":"2000","unstructured":"Fiordaliso F, Li B, Latini R, Sonnenblick EH, Anversa P, Leri A, Kajstura J (2000) Myocyte death in streptozotocin-induced diabetes in rats in angiotensin II- dependent. Lab Investig 80:513\u2013527","journal-title":"Lab Investig"},{"key":"648_CR18","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.freeradbiomed.2013.02.021","volume":"60","author":"K Huynh","year":"2013","unstructured":"Huynh K, Kiriazis H, Du XJ, Love JE, Grav SP, Jandeleit-Dahm KA, McMullen JR, Ritchie RH (2013) Targeting the upregulation of reactive oxygen species subsequent to hyperglycemia prevents type 1 diabetic cardiomyopathy in mice. Free Radic Biol Med 60:307\u2013317. \n                    https:\/\/doi.org\/10.1016\/j.freeradbiomed.2013.02.021","journal-title":"Free Radic Biol Med"},{"key":"648_CR19","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1038\/nrm1592","volume":"6","author":"S Krauss","year":"2005","unstructured":"Krauss S, Zhang CY, Lowell BB (2005) The mitochondrial uncoupling-protein homologues. Nat Rev Mol Cell Biol 6:248\u2013261. \n                    https:\/\/doi.org\/10.1038\/nrm1572","journal-title":"Nat Rev Mol Cell Biol"},{"key":"648_CR20","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1016\/j.freeradbiomed.2005.10.040","volume":"40","author":"OM Lashin","year":"2006","unstructured":"Lashin OM, Szweda PA, Szweda LI, Romani AM (2006) Decreased complex II respiration and HNE-modified SDH subunit in diabetic heart. Free Radic Biol Med 40:886\u2013896. \n                    https:\/\/doi.org\/10.1016\/j.freeradbiomed.2005.10.040","journal-title":"Free Radic Biol Med"},{"key":"648_CR21","doi-asserted-by":"publisher","first-page":"2254","DOI":"10.1021\/acs.jproteome.6b00250","volume":"15","author":"J Ma","year":"2016","unstructured":"Ma J, Banerjee P, Whelan SA, Liu T, Wei AC, Ramirez-Correa G, McComb ME, Costello CE, O'Rourke B, Murphy A, Hart GW (2016) Comparative proteomics reveals dysregulated mitochondrial O-GlcNAcylation in diabetic hearts. J Proteome Res 15:2254\u20132264. \n                    https:\/\/doi.org\/10.1021\/acs.jproteome.6b00250","journal-title":"J Proteome Res"},{"key":"648_CR22","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1161\/CIRCHEARTFAILURE.111.961565","volume":"5","author":"H Nakamura","year":"2012","unstructured":"Nakamura H, Matoba S, Iwai-Kanai E, Kimata M, Hoshino A, Nakaoka M, Katamura M, Okawa Y, Ariyoshi M, Mita Y, Ikeda K, Okigaki M, Adachi S, Tanaka H, Takamatsu T, Matsubara H (2012) p53 promotes cardiac dysfunction in diabetic mellitus caused by excessive mitochondrial respiration-mediated reactive oxygen species generation and lipid accumulation. Circ Heart Fail 5:106\u2013115. \n                    https:\/\/doi.org\/10.1161\/CIRCHEARTFAILURE.111.961565","journal-title":"Circ Heart Fail"},{"key":"648_CR23","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1002\/jcp.22138","volume":"224","author":"P Palsamy","year":"2010","unstructured":"Palsamy P, Subramanian S (2010) Ameliorative potential of resveratrol on proinflammatory cytokines, hyperglycemia mediated oxidative stress, and pancreatic beta-cell dysfunction in streptozotocin-nicotinamide-induced diabetic rats. J Cell Physiol 224:423\u2013432","journal-title":"J Cell Physiol"},{"key":"648_CR24","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.freeradbiomed.2017.02.032","volume":"106","author":"JL Pohjoism \u00e4ki","year":"2017","unstructured":"Pohjoism \u00e4ki JL, Goffart S (2017) The role of mitochondria in cardiac development and protection. Free Radic Biol Med 106:345\u2013354. \n                    https:\/\/doi.org\/10.1016\/j.freeradbiomed.2017.02.032","journal-title":"Free Radic Biol Med"},{"key":"648_CR25","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1002\/jcp.24833","volume":"230","author":"C Qiao","year":"2015","unstructured":"Qiao C, Wei L, Dai Q, Zhou Y, Yin Q, Li Z, Xiao Y, Guo Q, Lu N (2015) UCP2-related mitochondrial pathway participates in oroxylin A-induced apoptosis in human colon cancer cells. J Cell Physiol 230:1054\u20131063. \n                    https:\/\/doi.org\/10.1002\/jcp.24833","journal-title":"J Cell Physiol"},{"key":"648_CR26","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.pharmthera.2009.08.001","volume":"124","author":"RH Ritchie","year":"2009","unstructured":"Ritchie RH, Irvine JC, Rosenkranz AC, Patel R, Wendt IR, Horowitz JD, Kemp-Harper BK (2009) Exploiting cGMP-based therapies for the prevention of left ventricular hypertrophy: NO* and beyond. Pharmacol Ther 124:279\u2013300. \n                    https:\/\/doi.org\/10.1016\/j.pharmthera.2009.08.001","journal-title":"Pharmacol Ther"},{"key":"648_CR27","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/0002-9149(72)90595-4","volume":"30","author":"S Rubler","year":"1972","unstructured":"Rubler S, Dlugash J, Yuceoglu YZ, Kumral T, Branwood AW, Grishman A (1972) New type of cardiomyopathy associated with diabetic glomerulosclerosis. Am J Cardiol 30:595\u2013602","journal-title":"Am J Cardiol"},{"key":"648_CR28","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.exger.2017.03.017","volume":"93","author":"Y Rui","year":"2017","unstructured":"Rui Y, Cheng J, Qin L, Shan C, Chang J, Wang G, Wan Z (2017) Effects of vitamin D and resveratrol on metabolic associated markers in liver and adipose tissue from SAMP8 mice. Exp Gerontol 93:16\u201328. \n                    https:\/\/doi.org\/10.1016\/j.exger.2017.03.017","journal-title":"Exp Gerontol"},{"key":"648_CR29","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.ejphar.2014.07.029","volume":"741","author":"L Safaeian","year":"2014","unstructured":"Safaeian L, Abed A, Vaseghi G (2014) The role of Bcl-2 family proteins in pulmonary fibrosis. Eur J Pharmacol 741:281\u2013289. \n                    https:\/\/doi.org\/10.1016\/j.ejphar.2014.07.029","journal-title":"Eur J Pharmacol"},{"key":"648_CR30","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.arcmed.2015.05.005","volume":"46","author":"M Samsami-Kor","year":"2015","unstructured":"Samsami-Kor M, Daryani NE, Asl PR, Hekmatdoost A (2015) Anti-inflammatory effects of resveratrol in patients with ulcerative colitis: a randomized, double-blind, placebo-controlled pilot study. Arch Med Res 46:280\u2013285. \n                    https:\/\/doi.org\/10.1016\/j.arcmed.2015.05.005","journal-title":"Arch Med Res"},{"key":"648_CR31","doi-asserted-by":"publisher","first-page":"1515","DOI":"10.1089\/ars.2015.6294","volume":"22","author":"JD Schilling","year":"2015","unstructured":"Schilling JD (2015) The mitochondria in diabetic heart failure: from pathogenesis to therapeutic promise. Antioxid Redox Signal 22:1515\u20131526. \n                    https:\/\/doi.org\/10.1089\/ars.2015.6294","journal-title":"Antioxid Redox Signal"},{"key":"648_CR32","doi-asserted-by":"publisher","first-page":"2686","DOI":"10.1007\/s11064-012-0858-2","volume":"37","author":"JA Shin","year":"2012","unstructured":"Shin JA, Lee KE, Kim HS, Park EM (2012) Acute resveratrol treatment modulates multiple signaling pathways in the ischemic brain. Neurochem Res 37:2686\u20132696. \n                    https:\/\/doi.org\/10.1007\/s11064-012-0858-2","journal-title":"Neurochem Res"},{"key":"648_CR33","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/S0735-1097(03)00509-6","volume":"42","author":"T Shiomi","year":"2003","unstructured":"Shiomi T, Tsutsui H, Ikeuchi M, Matsusaka H, Hayashidani S, Suematsu N, Kubota T, Takeshita A (2003) Streptocin-induced hyperglycemia exacerbates left ventricular remodeling and failure after experimental myocardial infarction. J Am Coll Cardiol 42:165\u2013172","journal-title":"J Am Coll Cardiol"},{"key":"648_CR34","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1016\/j.amjcard.2012.03.030","volume":"110","author":"J Tome-Carneiro","year":"2012","unstructured":"Tome-Carneiro J, Gonzalvez M, Larrosa M, Y\u00e1\u00f1ez-Gasc\u00f3n MJ, Garc\u00eda-Almagro FJ, Ruiz-Ros JA, Garc\u00eda-Conesa MT, Tom\u00e1s-Barber\u00e1n FA, Esp\u00edn JC (2012) One-year consumption of a grape nutraceutical containing resveratrol improves the inflammatory and fibrinolytic status of patients in primary prevention of cardiovascular disease. Am J Cardiol 110:356\u2013363. \n                    https:\/\/doi.org\/10.1016\/j.amjcard.2012.03.030","journal-title":"Am J Cardiol"},{"key":"648_CR35","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/s10557-012-6427-8","volume":"27","author":"J Tome-Carneiro","year":"2013","unstructured":"Tome-Carneiro J, Gonzalvez M, Larrosa M, Y\u00e1\u00f1ez-Gasc\u00f3n MJ, Garc\u00eda-Almagro FJ, Ruiz-Ros JA, Tom\u00e1s-Barber\u00e1n FA, Garc\u00eda-Conesa MT, Esp\u00edn JC (2013) Grape resveratrol increases serum adiponectin and downregulates inflammatory genes in peripheral blood mononuclear cells: a triple-blind, placebo-controlled, one-year clinical trial in patients with stable coronary artery disease. Cardiovasc Drugs Ther 27:37\u201348. \n                    https:\/\/doi.org\/10.1007\/s10557-012-6427-8","journal-title":"Cardiovasc Drugs Ther"},{"key":"648_CR36","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.cub.2005.12.038","volume":"16","author":"DR Valenzano","year":"2006","unstructured":"Valenzano DR, Terzibasi E, Genade T, Cattaneo A, Domenici L, Cellerino A (2006) Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate. Curr Biol 16:296\u2013300. \n                    https:\/\/doi.org\/10.1016\/j.cub.2005.12.038","journal-title":"Curr Biol"},{"key":"648_CR37","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.cardiores.2004.02.013","volume":"63","author":"VP Empel Van","year":"2004","unstructured":"Van Empel VP, De Windt LJ (2004) Myocyte hypertrophy and apoptosis: a balancing act. Cardiovasc Res 63:487\u2013499. \n                    https:\/\/doi.org\/10.1016\/j.cardiores.2004.02.013","journal-title":"Cardiovasc Res"},{"key":"648_CR38","doi-asserted-by":"publisher","first-page":"3947","DOI":"10.2174\/138161211798764915","volume":"17","author":"VM Victor","year":"2011","unstructured":"Victor VM, Rocha M, Herance R, Hernandez-Mijares A (2011) Oxidative stress and mitochondrial dysfunction in type 2 diabetes. Curr Pharm Des 17:3947\u20133958","journal-title":"Curr Pharm Des"},{"key":"648_CR39","doi-asserted-by":"publisher","unstructured":"Wu H, Li GN, Xie J, Li R, Chen QH, Chen JZ, Wei ZH, Kang LN, Xu B (2016) Resveratrol ameliorates myocardial fibrosis by inhibiting ROS\/ERK\/TGF-beta\/periostin pathway in STZ-induced diabetic mice. BMC Cardiovasc Disord. \n                    https:\/\/doi.org\/10.1186\/s12872-015-0169-z.16\n                    \n                  : 5","DOI":"10.1186\/s12872-015-0169-z.16"},{"key":"648_CR40","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/S0960-9822(02)01433-1","volume":"13","author":"N Zamzami","year":"2003","unstructured":"Zamzami N, Kroemer G (2003) Apoptosis: mitochondrial membrane permeabilization--the (w)hole story? Curr Biol 13:71\u201373","journal-title":"Curr Biol"}],"container-title":["Journal of Physiology and Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13105-018-0648-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13105-018-0648-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13105-018-0648-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,16]],"date-time":"2019-09-16T19:15:30Z","timestamp":1568661330000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s13105-018-0648-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,17]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["648"],"URL":"https:\/\/doi.org\/10.1007\/s13105-018-0648-7","relation":{},"ISSN":["1138-7548","1877-8755"],"issn-type":[{"value":"1138-7548","type":"print"},{"value":"1877-8755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,17]]},"assertion":[{"value":"16 March 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 September 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 September 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that there are no conflicts of interest with this work.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}