{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T04:34:21Z","timestamp":1769315661257,"version":"3.49.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T00:00:00Z","timestamp":1542067200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["No. 81571842"],"award-info":[{"award-number":["No. 81571842"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Physiol Biochem"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1007\/s13105-018-0657-6","type":"journal-article","created":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T17:58:02Z","timestamp":1542131882000},"page":"73-81","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["The protective microRNA-199a-5p-mediated unfolded protein response in hypoxic cardiomyocytes is regulated by STAT3 pathway"],"prefix":"10.1007","volume":"75","author":[{"given":"Yang","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Pang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingbin","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huali","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,11,13]]},"reference":[{"issue":"9","key":"657_CR1","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1016\/j.tem.2015.06.008","volume":"26","author":"HE Azzouzi","year":"2015","unstructured":"Azzouzi HE, Leptidis S, Doevendans PA, De Windt LJ (2015) HypoxamiRs: regulators of cardiac hypoxia and energy metabolism. Trends Endocrinol Metab 26(9):502\u2013508. \n                    https:\/\/doi.org\/10.1016\/j.tem.2015.06.008","journal-title":"Trends Endocrinol Metab"},{"issue":"10","key":"657_CR2","doi-asserted-by":"publisher","first-page":"3658","DOI":"10.1158\/0008-5472.CAN-10-3647","volume":"71","author":"BB Dai","year":"2011","unstructured":"Dai BB, Meng JR, Peyton M, Girard L, Bornmann WG, Ji L, Minna JD, Fang BL, Roth JA (2011) STAT3 mediates resistance to MEK inhibitor through MicroRNA miR-17. Cancer Res 71(10):3658\u20133668. \n                    https:\/\/doi.org\/10.1158\/0008-5472.CAN-10-3647","journal-title":"Cancer Res"},{"key":"657_CR3","doi-asserted-by":"publisher","first-page":"e604","DOI":"10.1038\/cddis.2013.134","volume":"4","author":"BH Dai","year":"2013","unstructured":"Dai BH, Geng L, Wang Y, Sui CJ, Xie F, Shen RX, Shen WF, Yang JM (2013) microRNA-199a-5p protects hepatocytes from bile acid-induced sustained endoplasmic reticulum stress. Cell Death Dis 4:e604. \n                    https:\/\/doi.org\/10.1038\/cddis.2013.134","journal-title":"Cell Death Dis"},{"issue":"6","key":"657_CR4","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1016\/j.yjmcc.2012.09.007","volume":"53","author":"A Das","year":"2012","unstructured":"Das A, Salloum FN, Durrant D, Ockaili R, Kukreja RC (2012) Rapamycin protects against myocardial ischemia-reperfusion injury through JAK2-STAT3 signaling pathway. J Mol Cell Cardiol 53(6):858\u2013869. \n                    https:\/\/doi.org\/10.1016\/j.yjmcc.2012.09.007","journal-title":"J Mol Cell Cardiol"},{"issue":"1","key":"657_CR5","doi-asserted-by":"publisher","first-page":"3","DOI":"10.2174\/157016111301150303121746","volume":"13","author":"V Fineschi","year":"2015","unstructured":"Fineschi V (2015) Measuring myocyte oxidative stress and targeting cytokines to evaluate inflammatory response and cardiac repair after myocardial infarction. Curr Vasc Pharmacol 13(1):3\u20135","journal-title":"Curr Vasc Pharmacol"},{"issue":"5","key":"657_CR6","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1016\/j.biochi.2011.02.009","volume":"93","author":"Q Gu","year":"2011","unstructured":"Gu Q, Kong Y, Yu ZB, Bai L, Xiao YB (2011) Hypoxia-induced SOCS3 is limiting STAT3 phosphorylation and NF-kappa B activation in congenital heart disease. Biochimie 93(5):909\u2013920. \n                    https:\/\/doi.org\/10.1016\/j.biochi.2011.02.009","journal-title":"Biochimie"},{"issue":"8","key":"657_CR7","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1038\/nrm3838","volume":"15","author":"M Ha","year":"2014","unstructured":"Ha M, Kim VN (2014) Regulation of microRNA biogenesis. Nat Rev Mol Cell Biol 15(8):509\u2013524. \n                    https:\/\/doi.org\/10.1038\/nrm3838","journal-title":"Nat Rev Mol Cell Biol"},{"key":"657_CR8","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1093\/eurheartj\/ehq369","volume":"32","author":"A Haghikia","year":"2011","unstructured":"Haghikia A, Missol-Kolka E, Tsikas D, Venturini L, Brundiers S, Castoldi M, Muckenthaler MU, Eder M, Stapel B, Thum T, Haghikia A, Petrasch-Parwez E, Drexler H, Hilfiker-Kleiner D, Scherr M (2011) Signal transducer and activator of transcription 3-mediated regulation of miR-199a-5p links cardiomyocyte and endothelial cell function in the heart: a key role for ubiquitin-conjugating enzymes. Eur Heart J 32:1287\u20131297. \n                    https:\/\/doi.org\/10.1093\/eurheartj\/ehq369","journal-title":"Eur Heart J"},{"issue":"1","key":"657_CR9","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/s13105-013-0294-z","volume":"70","author":"Q Han","year":"2014","unstructured":"Han Q, Yeung SC, Ip MS, Mak JC (2014) Cellular mechanisms in intermittent hypoxia-induced cardiac damage in vivo. J Physiol Biochem 70(1):201\u2013213. \n                    https:\/\/doi.org\/10.1007\/s13105-013-0294-z","journal-title":"J Physiol Biochem"},{"issue":"3","key":"657_CR10","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1038\/icb.2011.112","volume":"90","author":"SZ Hasnain","year":"2012","unstructured":"Hasnain SZ, Lourie R, Das I, Chen ACH, McGuckin MA (2012) The interplay between endoplasmic reticulum stress and inflammation. Immunol Cell Biol 90(3):260\u2013270. \n                    https:\/\/doi.org\/10.1038\/icb.2011.112","journal-title":"Immunol Cell Biol"},{"issue":"3","key":"657_CR11","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1164\/rccm.201306-1151OC","volume":"189","author":"T Hassan","year":"2014","unstructured":"Hassan T, Carroll TP, Buckley PG, Cummins R, O'Neill SJ, McElvaney NG, Greene CM (2014) miR-199a-5p silencing regulates the unfolded protein response in chronic obstructive pulmonary disease and alpha1-antitrypsin deficiency. Am J Respir Crit Care Med 189(3):263\u2013273. \n                    https:\/\/doi.org\/10.1164\/rccm.201306-1151OC","journal-title":"Am J Respir Crit Care Med"},{"issue":"3","key":"657_CR12","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1007\/s13105-017-0561-5","volume":"73","author":"S He","year":"2016","unstructured":"He S, Liu S, Wu X, Xin M, Ding S, Xin D, Ouyang H, Zhang J (2016) Protective role of downregulated MLK3 in myocardial adaptation to chronic hypoxia. J Physiol Biochem 73(3):371\u2013380. \n                    https:\/\/doi.org\/10.1007\/s13105-017-0561-5","journal-title":"J Physiol Biochem"},{"issue":"3","key":"657_CR13","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1007\/s00395-012-0268-2","volume":"107","author":"LC Heather","year":"2012","unstructured":"Heather LC, Cole MA, Tan JJ, Ambrose LJ, Pope S, Abd-Jamil AH, Carter EE, Dodd MS, Yeoh KK, Schofield CJ, Clarke K (2012) Metabolic adaptation to chronic hypoxia in cardiac mitochondria. Basic Res Cardiol 107(3):268. \n                    https:\/\/doi.org\/10.1007\/s00395-012-0268-2","journal-title":"Basic Res Cardiol"},{"issue":"3","key":"657_CR14","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1097\/QCO.0b013e328344f50f","volume":"24","author":"PJ Hohensinner","year":"2011","unstructured":"Hohensinner PJ, Niessner A, Huber K, Weyand CM, Wojta J (2011) Inflammation and cardiac outcome. Curr Opin Infect Dis 24(3):259\u2013264. \n                    https:\/\/doi.org\/10.1097\/QCO.0b013e328344f50f","journal-title":"Curr Opin Infect Dis"},{"issue":"3","key":"657_CR15","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1002\/path.4295","volume":"232","author":"CY Hsu","year":"2014","unstructured":"Hsu CY, Hsieh TH, Tsai CF, Tsai HP, Chen HS, Chang Y, Chuang HY, Lee JN, Hsu YL, Tsai EM (2014) miRNA-199a-5p regulates VEGFA in endometrial mesenchymal stem cells and contributes to the pathogenesis of endometriosis. J Pathol 232(3):330\u2013343. \n                    https:\/\/doi.org\/10.1002\/path.4295","journal-title":"J Pathol"},{"issue":"22","key":"657_CR16","doi-asserted-by":"publisher","first-page":"12929","DOI":"10.1073\/pnas.2134694100","volume":"100","author":"JJ Jacoby","year":"2003","unstructured":"Jacoby JJ, Kalinowski A, Liu MG, Zhang SS, Gao Q, Chai GX, Ji L, Iwamoto Y, Li E, Schneider M, Russell KS, Fu XY (2003) Cardiomyocyte-restricted knockout of STAT3 results in higher sensitivity to inflammation, cardiac fibrosis, and heart failure with advanced age. Proc Natl Acad Sci U S A 100(22):12929\u201312934. \n                    https:\/\/doi.org\/10.1073\/pnas.2134694100","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"657_CR17","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1002\/cbf.2820","volume":"30","author":"YH Jia","year":"2012","unstructured":"Jia YH, Zhou FH, Deng P, Fan Q, Li CH, Liu YW, Fu XQ, Zhou YC, Xu X, Sun XG (2012) Interleukin 6 protects H2O2-induced cardiomyocytes injury through upregulation of prohibitin via STAT3 phosphorylation. Cell Biochem Funct 30(5):426\u2013431. \n                    https:\/\/doi.org\/10.1002\/cbf.2820","journal-title":"Cell Biochem Funct"},{"issue":"3","key":"657_CR18","doi-asserted-by":"publisher","first-page":"141","DOI":"10.2144\/000113999","volume":"54","author":"C Lee","year":"2013","unstructured":"Lee C, Huang CH (2013) LASAGNA-Search: an integrated web tool for transcription factor binding site search and visualization. Biotechniques 54(3):141\u2013153. \n                    https:\/\/doi.org\/10.2144\/000113999","journal-title":"Biotechniques"},{"issue":"1","key":"657_CR19","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1093\/nar\/gkn920","volume":"37","author":"YB Lee","year":"2009","unstructured":"Lee YB, Bantounas I, Lee DY, Phylactou L, Caldwell MA, Uney JB (2009) Twist-1 regulates the miR-199a\/214 cluster during development. Nucleic Acids Res 37(1):123\u2013128. \n                    https:\/\/doi.org\/10.1093\/nar\/gkn920","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"657_CR20","doi-asserted-by":"publisher","first-page":"D110","DOI":"10.1093\/nar\/gkv1176","volume":"44","author":"A Mathelier","year":"2016","unstructured":"Mathelier A, Fornes O, Arenillas DJ, Chen CY, Denay G, Lee J, Shi WQ, Shyr C, Tan G, Worsley-Hunt R, Zhang AW, Parcy F, Lenhard B, Sandelin A, Wasserman WW (2016) JASPAR 2016: a major expansion and update of the open-access database of transcription factor binding profiles. Nucleic Acids Res 44(D1):D110\u2013D115. \n                    https:\/\/doi.org\/10.1093\/nar\/gkv1176","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"657_CR21","doi-asserted-by":"publisher","first-page":"26","DOI":"10.2174\/15701611113119990003","volume":"13","author":"M Neri","year":"2015","unstructured":"Neri M, Fineschi V, Di Paolo M, Pomara C, Riezzo I, Turillazzi E, Cerretani D (2015) Cardiac oxidative stress and inflammatory cytokines response after myocardial infarction. Curr Vasc Pharmacol 13(1):26\u201336","journal-title":"Curr Vasc Pharmacol"},{"issue":"5","key":"657_CR22","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1161\/CIRCULATIONAHA.109.893677","volume":"121","author":"M Obana","year":"2010","unstructured":"Obana M, Maeda M, Takeda K, Hayama A, Mohri T, Yamashita T, Nakaoka Y, Komuro I, Takeda K, Matsumiya G, Azuma J, Fujio Y (2010) Therapeutic activation of signal transducer and activator of transcription 3 by interleukin-11 ameliorates cardiac fibrosis after myocardial infarction. Circulation 121(5):684\u2013691. \n                    https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.109.893677","journal-title":"Circulation"},{"issue":"5","key":"657_CR23","doi-asserted-by":"publisher","first-page":"H569","DOI":"10.1152\/ajpheart.00060.2012","volume":"303","author":"M Obana","year":"2012","unstructured":"Obana M, Miyamoto K, Murasawa S, Iwakura T, Hayama A, Yamashita T, Shiragaki M, Kumagai S, Miyawaki A, Takewaki K, Matsumiya G, Maeda M, Yoshiyama M, Nakayama H, Fujio Y (2012) Therapeutic administration of IL-11 exhibits the postconditioning effects against ischemia-reperfusion injury via STAT3 in the heart. Am J Phys Heart Circ Phys 303(5):H569\u2013H577. \n                    https:\/\/doi.org\/10.1152\/ajpheart.00060.2012","journal-title":"Am J Phys Heart Circ Phys"},{"issue":"7","key":"657_CR24","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1161\/CIRCRESAHA.108.193102","volume":"104","author":"S Rane","year":"2009","unstructured":"Rane S, He M, Sayed D, Vashistha H, Malhotra A, Sadoshima J, Vatner DE, Vatner SF, Abdellatif M (2009) Downregulation of miR-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes. Circ Res 104(7):879\u2013886. \n                    https:\/\/doi.org\/10.1161\/CIRCRESAHA.108.193102","journal-title":"Circ Res"},{"issue":"2","key":"657_CR25","doi-asserted-by":"publisher","first-page":"243","DOI":"10.4161\/15384101.2014.977112","volume":"14","author":"XX Sun","year":"2015","unstructured":"Sun XX, Zhang J, Hou ZH, Han QJ, Zhang C, Tian ZG (2015) miR-146a is directly regulated by STAT3 in human hepatocellular carcinoma cells and involved in anti-tumor immune suppression. Cell Cycle 14(2):243\u2013252. \n                    https:\/\/doi.org\/10.4161\/15384101.2014.977112","journal-title":"Cell Cycle"},{"issue":"3","key":"657_CR26","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1161\/01.RES.0000233317.70421.03","volume":"99","author":"DJ Thuerauf","year":"2006","unstructured":"Thuerauf DJ, Marcinko M, Gude N, Rubio M, Sussman MA, Glembotski CC (2006) Activation of the unfolded protein response in infarcted mouse heart and hypoxic cultured cardiac myocytes. Circ Res 99(3):275\u2013282. \n                    https:\/\/doi.org\/10.1161\/01.RES.0000233317.70421.03","journal-title":"Circ Res"},{"issue":"11","key":"657_CR27","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1038\/nrd3864","volume":"11","author":"E Rooij van","year":"2012","unstructured":"van Rooij E, Olson EN (2012) MicroRNA therapeutics for cardiovascular disease: opportunities and obstacles. Nat Rev Drug Discov 11(11):860\u2013872. \n                    https:\/\/doi.org\/10.1038\/nrd3864","journal-title":"Nat Rev Drug Discov"},{"issue":"12","key":"657_CR28","doi-asserted-by":"publisher","first-page":"1727","DOI":"10.1007\/s10495-014-1039-3","volume":"19","author":"M Wang","year":"2014","unstructured":"Wang M, Meng XB, Yu YL, Sun GB, Xu XD, Zhang XP, Dong X, Ye JX, Xu HB, Sun YF, Sun XB (2014) Elatoside C protects against hypoxia\/reoxygenation-induced apoptosis in H9c2 cardiomyocytes through the reduction of endoplasmic reticulum stress partially depending on STAT3 activation. Apoptosis 19(12):1727\u20131735. \n                    https:\/\/doi.org\/10.1007\/s10495-014-1039-3","journal-title":"Apoptosis"},{"issue":"7203","key":"657_CR29","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1038\/nature07203","volume":"454","author":"K Zhang","year":"2008","unstructured":"Zhang K, Kaufman RJ (2008) From endoplasmic-reticulum stress to the inflammatory response. Nature 454(7203):455\u2013462. \n                    https:\/\/doi.org\/10.1038\/nature07203","journal-title":"Nature"},{"issue":"3","key":"657_CR30","doi-asserted-by":"publisher","first-page":"2992","DOI":"10.3892\/mmr.2017.6934","volume":"16","author":"Y Zhou","year":"2017","unstructured":"Zhou Y, Jia WK, Jian Z, Zhao L, Liu CC, Wang Y, Xiao YB (2017) Downregulation of microRNA199a5p protects cardiomyocytes in cyanotic congenital heart disease by attenuating endoplasmic reticulum stress. Mol Med Rep 16(3):2992\u20133000. \n                    https:\/\/doi.org\/10.3892\/mmr.2017.6934","journal-title":"Mol Med Rep"}],"container-title":["Journal of Physiology and Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13105-018-0657-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13105-018-0657-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13105-018-0657-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T19:26:46Z","timestamp":1573586806000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s13105-018-0657-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,13]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["657"],"URL":"https:\/\/doi.org\/10.1007\/s13105-018-0657-6","relation":{},"ISSN":["1138-7548","1877-8755"],"issn-type":[{"value":"1138-7548","type":"print"},{"value":"1877-8755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,13]]},"assertion":[{"value":"5 December 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 October 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 November 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}