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AMPK is an important intracellular energy sensor and plays a relevant role in whole-body energy homeostasis. AMPK is activated, among others, in response to glucose deprivation, caloric restriction and increased physical activity. Upon activation, AMPK affects metabolic pathways leading to increased formation of ATP and simultaneously reducing ATP-consuming processes. AMPK is also expressed in pancreatic \u03b2 cells and is largely regulated by glucose, which is the main physiological stimulator of insulin secretion. Results of in vitro studies clearly show that glucose-induced insulin release is associated with a concomitant inhibition of AMPK in \u03b2 cells. However, pharmacological activation of AMPK significantly potentiates the insulin-secretory response of \u03b2 cells to glucose and to some other stimuli. This effect is primarily due to increased intracellular calcium concentrations. AMPK is also involved in the regulation of gene expression and may protect \u03b2 cells against glucolipotoxic conditions. It was shown that in pancreatic islets of humans with type 2 diabetes, AMPK is downregulated. Moreover, studies with animal models demonstrated impaired link between glucose and AMPK activity in pancreatic islet cells. These data suggest that AMPK may be a target for compounds improving the functionality of \u03b2 cells. However, more studies are required to better elucidate the relevance of AMPK in the (patho)physiology of the insulin-secreting cells.<\/jats:p>","DOI":"10.1007\/s13105-019-00706-3","type":"journal-article","created":{"date-parts":[[2019,11,5]],"date-time":"2019-11-05T22:33:30Z","timestamp":1572993210000},"page":"423-432","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["The relevance of AMP-activated protein kinase in insulin-secreting \u03b2 cells: a potential target for improving \u03b2 cell function?"],"prefix":"10.1007","volume":"75","author":[{"given":"Tomasz","family":"Szkudelski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Szkudelska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,11,5]]},"reference":[{"key":"706_CR1","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.bbabio.2008.03.022","volume":"1777","author":"C Affourtit","year":"2008","unstructured":"Affourtit C, Brand MD (2008) On the role of uncoupling protein-2 in pancreatic \u03b2-cells. 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