{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T20:24:45Z","timestamp":1780345485463,"version":"3.54.1"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T00:00:00Z","timestamp":1648598400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T00:00:00Z","timestamp":1648598400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Physiol Biochem"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1007\/s13105-022-00891-8","type":"journal-article","created":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T04:16:09Z","timestamp":1648613769000},"page":"593-601","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Role of the voltage-gated proton channel Hv1 in insulin secretion, glucose homeostasis, and obesity"],"prefix":"10.1007","volume":"78","author":[{"given":"Huimin","family":"Pang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinwen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu Jie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,3,30]]},"reference":[{"key":"891_CR1","doi-asserted-by":"publisher","first-page":"S62","DOI":"10.2337\/dc11-S062","volume":"34","author":"American Diabetes Association","year":"2011","unstructured":"American Diabetes Association (2011) Diagnosis and classification of diabetes mellitus. Diabetes Care 34:S62-69","journal-title":"Diabetes Care"},{"key":"891_CR2","doi-asserted-by":"publisher","first-page":"S13","DOI":"10.2337\/dc18-S002","volume":"41","author":"American Diabetes Association","year":"2018","unstructured":"American Diabetes Association (2018) Classification and diagnosis of diabetes: standards of medical care in diabetes. Diabetes Care 41:S13\u2013S27","journal-title":"Diabetes Care"},{"key":"891_CR3","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1111\/j.1600-6143.2006.01577.x","volume":"7","author":"B Armann","year":"2007","unstructured":"Armann B, Hanson MS, Hatch E, Steffen A, Fernandez LA (2007) Quantification of basal and stimulated ROS levels as predictors of islet potency and function. Am J Transplant 7:38\u201347","journal-title":"Am J Transplant"},{"key":"891_CR4","doi-asserted-by":"publisher","first-page":"31308","DOI":"10.1074\/jbc.272.50.31308","volume":"272","author":"CA Aspinwall","year":"1997","unstructured":"Aspinwall CA, Brooks SA, Kennedy RT, Lakey JR (1997) Effects of intravesicular H+ and extracellular H+ and Zn2+ on insulin secretion in pancreatic beta cells. J Biol Chem 272:31308\u201331314","journal-title":"J Biol Chem"},{"key":"891_CR5","doi-asserted-by":"publisher","first-page":"3308","DOI":"10.1016\/S0006-3495(01)75964-4","volume":"81","author":"S Barg","year":"2001","unstructured":"Barg S, Ma X, Eliasson L, Galvanovskis J, G\u00f6pel SO, Oberm\u00fcller S, Platzer J, Renstr\u00f6m E, Trus M, Atlas D, Striessnig J, Rorsman P (2001) Fast exocytosis with few Ca2+ channels in insulin-secreting mouse pancreatic B cells. Biophys J 81:3308\u20133323","journal-title":"Biophys J"},{"key":"891_CR6","doi-asserted-by":"publisher","first-page":"2145","DOI":"10.1242\/jcs.114.11.2145","volume":"114","author":"S Barg","year":"2001","unstructured":"Barg S, Huang P, Eliasson L, Nelson DJ, Oberm\u00fcller S, Rorsman P, Th\u00e9venod F, Renstr\u00f6m E (2001) Priming of insulin granules for exocytosis by granular Cl(-) uptake and acidification. J Cell Sci 114:2145\u20132154","journal-title":"J Cell Sci"},{"key":"891_CR7","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1113\/jphysiol.1993.sp019860","volume":"470","author":"L Bernheim","year":"1993","unstructured":"Bernheim L, Krause RM, Baroffio A, Hamann M, Kaelin A, Bader CR (1993) A voltage-dependent proton current in cultured human skeletal muscle myotubes. J Physiol 470:313\u2013333","journal-title":"J Physiol"},{"key":"891_CR8","doi-asserted-by":"publisher","first-page":"9796","DOI":"10.1074\/jbc.M206913200","volume":"278","author":"VP Bindokas","year":"2003","unstructured":"Bindokas VP, Kuznetsov A, Sreenan S, Polonsky KS, Roe MW, Philipson LH (2003) Visualizing superoxide production in normal and diabetic rat islets of Langerhans. J Biol Chem 278:9796\u20139801","journal-title":"J Biol Chem"},{"key":"891_CR9","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.endonu.2016.03.011","volume":"63","author":"CY Brito","year":"2016","unstructured":"Brito CY, Meli\u00e1n C, Wgner AM (2016) Study of the pathogenesis and treatment of diabetes mellitus through animal models. Endocrinol Nutr 63:345\u2013353","journal-title":"Endocrinol Nutr"},{"key":"891_CR10","first-page":"1","volume":"9","author":"MG Burhans","year":"2018","unstructured":"Burhans MG, Hagman DK, Kuzma JN, Schmidt KA, Kratz M (2018) Contribution of adipose tissue inflammation to the development of type 2 diabetes mellitus. Compr Physiol 9:1\u201358","journal-title":"Compr Physiol"},{"key":"891_CR11","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1111\/imm.12326","volume":"143","author":"M Capasso","year":"2014","unstructured":"Capasso M (2014) Regulation of immune responses by proton channels. Immunology 143:131\u2013137","journal-title":"Immunology"},{"key":"891_CR12","first-page":"245","volume":"23","author":"A Chatzigeorgiou","year":"2009","unstructured":"Chatzigeorgiou A, Halapas A, Kalafatakis K, Kamper E (2009) The use of animal models in the study of diabetes mellitus. In Vivo 23:245\u2013258","journal-title":"In Vivo"},{"key":"891_CR13","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1038\/nri3071","volume":"11","author":"A Chawla","year":"2011","unstructured":"Chawla A, Nguyen KD, Goh YP (2011) Macrophage-mediated inflammation in metabolic disease. Nat Rev Immunol 11:738\u2013749","journal-title":"Nat Rev Immunol"},{"key":"891_CR14","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1111\/j.1463-1326.2004.00392.x","volume":"7","author":"D Chen","year":"2005","unstructured":"Chen D, Wang MW (2005) Development and application of rodent models for type 2 diabetes. Diabetes Obes Metab 7:307\u2013317","journal-title":"Diabetes Obes Metab"},{"key":"891_CR15","doi-asserted-by":"publisher","first-page":"e33298","DOI":"10.7554\/eLife.33298","volume":"6","author":"CHJ Choi","year":"2017","unstructured":"Choi CHJ, Cohen P (2017) How does obesity lead to IR? eLife 6:e33298","journal-title":"eLife"},{"key":"891_CR16","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1042\/bj3151015","volume":"315","author":"VN Civelek","year":"1996","unstructured":"Civelek VN, Deeney JT, Kubik K, Schultz V, Tornheim K, Corkey BE (1996) Temporal sequence of metabolic and ionic events in glucose-stimulated clonal pancreatic beta-cells (HIT). Biochem J 315:1015\u20131019","journal-title":"Biochem J"},{"key":"891_CR17","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.2337\/diabetes.48.9.1686","volume":"48","author":"S Daniel","year":"1999","unstructured":"Daniel S, Noda M, Straub SG, Sharp GW (1999) Identification of the docked granule pool responsible for the first phase of glucose-stimulated insulin secretion. Diabetes 48:1686\u20131690","journal-title":"Diabetes"},{"key":"891_CR18","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1152\/physrev.00028.2002","volume":"83","author":"TE Decoursey","year":"2003","unstructured":"Decoursey TE (2003) Voltage-gated proton channels and other proton transfer pathways. Physiol Rev 83:475\u2013579","journal-title":"Physiol Rev"},{"key":"891_CR19","doi-asserted-by":"publisher","first-page":"S38","DOI":"10.1016\/j.amjmed.2009.12.008","volume":"123","author":"RA DeFronzo","year":"2010","unstructured":"DeFronzo RA (2010) Current issues in the treatment of type 2 diabetes. Overview of newer agents: where treatment is going. Am J Med 123:S38\u2013S48","journal-title":"Am J Med"},{"key":"891_CR20","doi-asserted-by":"publisher","first-page":"2044","DOI":"10.1074\/jbc.273.4.2044","volume":"273","author":"N Demaurex","year":"1998","unstructured":"Demaurex N, Furuya W, D\u2019Souza S, Bonifacino JS, Grinstein S (1998) Mechanism of acidification of the trans-Golginetwork (TGN). In situ measurements of pH using retrieval of TGN38 and furin from the cell surface. J Biol Chem 273:2044\u20132051","journal-title":"J Biol Chem"},{"key":"891_CR21","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.ceca.2010.07.007","volume":"48","author":"SB Dula","year":"2010","unstructured":"Dula SB, Jecmenica M, Wu R, Jahanshahi P, Verrilli GM, Carter JD, Brayman KL, Nunemaker CS (2010) Evidence that low-grade systemic inflammation can induce islet dysfunction as measured by impaired calcium handling. Cell Calcium 48:133\u2013142","journal-title":"Cell Calcium"},{"key":"891_CR22","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1034\/j.1600-079X.2001.280201.x","volume":"28","author":"H Ebelt","year":"2000","unstructured":"Ebelt H, Peschke D, Bromme HJ, Morke W, Blume R, Peschke E (2000) Influence of melatonin on free radical-induced changes in rat pancreatic beta-cells in vitro. J Pineal Res 28:65\u201372","journal-title":"J Pineal Res"},{"key":"891_CR23","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1084\/jem.20091837","volume":"207","author":"A El Chemaly","year":"2010","unstructured":"El Chemaly A, Okochi Y, Sasaki M, Arnaudeau S, Okamura Y, Demaurex N (2010) VSOP\/Hv1 proton channels sustain calcium entry, neutrophil migration, and superoxide production by limiting cell depolarization and acidification. J Exp Med 207:129\u2013139","journal-title":"J Exp Med"},{"key":"891_CR24","doi-asserted-by":"publisher","first-page":"25","DOI":"10.2174\/157339913804143225","volume":"9","author":"Z Fu","year":"2013","unstructured":"Fu Z, Gilbert ER, Liu D (2013) Regulation of insulin synthesis and secretion and pancreatic beta-cell dysfunction in diabetes. Curr Diabetes Rev 9:25\u201353","journal-title":"Curr Diabetes Rev"},{"key":"891_CR25","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1172\/JCI115714","volume":"89","author":"M Gembal","year":"1992","unstructured":"Gembal M, Gilon P, Henquin JC (1992) Evidence that glucose can control insulin release independently from its action on ATP-sensitive K+ channels in mouse B cells. J Clin Investig 89:1288\u20131295","journal-title":"J Clin Investig"},{"key":"891_CR26","doi-asserted-by":"publisher","first-page":"10379","DOI":"10.1074\/jbc.M111.304998","volume":"287","author":"CY Han","year":"2012","unstructured":"Han CY, Umemoto T, Omer M et al (2012) NADPH oxidase-derived reactive oxygen species increases expression of monocyte chemotactic factor genes in cultured adipocytes. J Biol Chem 287:10379\u201310393","journal-title":"J Biol Chem"},{"key":"891_CR27","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1042\/bj2460325","volume":"246","author":"LM Henderson","year":"1987","unstructured":"Henderson LM, Chappell JB, Jones OT (1987) The superoxide-generating NADPH oxidase of human neutrophils is electrogenic and associated with an H+ channel. Biochem J 246:325\u2013329","journal-title":"Biochem J"},{"key":"891_CR28","first-page":"285","volume":"255","author":"LM Henderson","year":"1988","unstructured":"Henderson LM, Chappell JB, Jones OT (1988) Superoxide generation by the electrogenic NADPH oxidase of human neutrophils is limited by the movement of a compensating charge. Biochem J 255:285\u2013290","journal-title":"Biochem J"},{"key":"891_CR29","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1042\/bj2510563","volume":"251","author":"LM Henderson","year":"1988","unstructured":"Henderson LM, Chappell JB, Jones OT (1988) Internal pH changes associated with the activity of NADPH oxidase of human neutrophils. Further evidence for the presence of an H+ conducting channel. Biochem J 251:563\u2013567","journal-title":"Biochem J"},{"key":"891_CR30","doi-asserted-by":"publisher","first-page":"1751","DOI":"10.2337\/diabetes.49.11.1751","volume":"49","author":"JC Henquin","year":"2000","unstructured":"Henquin JC (2000) Triggering and amplifying pathways of regulation of insulin secretion by glucose. Diabetes 49:1751\u20131760","journal-title":"Diabetes"},{"key":"891_CR31","doi-asserted-by":"publisher","first-page":"S27","DOI":"10.1016\/S0168-8227(11)70010-9","volume":"93","author":"JC Henquin","year":"2011","unstructured":"Henquin JC (2011) The dual control of insulin secretion by glucose involves triggering and amplifying pathways in \u03b2-cells. Diabetes Res Clin Pract 93:S27\u2013S31","journal-title":"Diabetes Res Clin Pract"},{"key":"891_CR32","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1126\/science.7678183","volume":"259","author":"GS Hotamisligil","year":"1993","unstructured":"Hotamisligil GS, Shargill NS, Spiegelman BM (1993) Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked IR. Science 259:87\u201391","journal-title":"Science"},{"key":"891_CR33","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1007\/BF00265542","volume":"32","author":"JC Hutton","year":"1989","unstructured":"Hutton JC (1989) The insulin secretory granule. Diabetologia 32:271\u2013281","journal-title":"Diabetologia"},{"key":"891_CR34","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/S0006-2952(98)00346-3","volume":"57","author":"D Janjic","year":"1999","unstructured":"Janjic D, Maechler P, Sekine N, Bartley C, Annen AS, Wolheim CB (1999) Free radical modulation of insulin release in INS-1 cells exposed to alloxan. Biochem Pharmacol 57:639\u2013648","journal-title":"Biochem Pharmacol"},{"key":"891_CR35","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.2174\/092986707781058887","volume":"14","author":"H Kaneto","year":"2007","unstructured":"Kaneto H, Miyatsuka T, Shiraiwa T, Yamamoto K, Kato K, Fujitani Y, Matsuoka TA (2007) Crucial role of PDX-1 in pancreas development, beta-cell differentiation, and induction of surrogate beta-cells. Curr Med Chem 14:1745\u20131752","journal-title":"Curr Med Chem"},{"key":"891_CR36","doi-asserted-by":"publisher","first-page":"27905","DOI":"10.1074\/jbc.274.39.27905","volume":"274","author":"P Maechler","year":"1999","unstructured":"Maechler P, Jornot L, Wollheim CB (1999) Hydrogen peroxide alters mitochondrial activation and insulin secretion in pancreatic beta cells. J Biol Chem 274:27905\u201327913","journal-title":"J Biol Chem"},{"key":"891_CR37","first-page":"558","volume":"71","author":"T Maksymets","year":"2018","unstructured":"Maksymets T, Karpyshyn N, Gutor T, Sklyarova H, Sklyarov E (2018) Influence of risk factors on insulin resistance in patients with overweight and obesity. Wiad Lek 71:558\u2013560","journal-title":"Wiad Lek"},{"key":"891_CR38","doi-asserted-by":"publisher","first-page":"20389","DOI":"10.1074\/jbc.M411869200","volume":"280","author":"GA Martens","year":"2005","unstructured":"Martens GA, Cai Y, Hinke S, Stang\u00e9 G, Van de Casteele M, Pipeleers D (2005) Glucose suppresses superoxide generation in metabolically responsive pancreatic beta cells. J Biol Chem 280:20389\u201320396","journal-title":"J Biol Chem"},{"key":"891_CR39","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1007\/s00125-006-0462-6","volume":"50","author":"D Morgan","year":"2007","unstructured":"Morgan D, Oliveira-Emilio HR, Keane D, Hirata AE, Santos da Rocha M, Bordin S, Curi R, Newsholme P, Carpinelli AR (2007) Glucose, palmitate and pro-inflammatory cytokines modulate production and activity of a phagocyte-like NADPH oxidase in rat pancreatic islets and a clonal beta cell line. Diabetologia 50:359\u2013369","journal-title":"Diabetologia"},{"key":"891_CR40","doi-asserted-by":"publisher","first-page":"18022","DOI":"10.1073\/pnas.0905565106","volume":"106","author":"D Morgan","year":"2009","unstructured":"Morgan D, Capasso M, Musset B et al (2009) Voltage-gated proton channels maintain pH in human neutrophils during phagocytosis. Proc Natl Acad Sci USA 106:18022\u201318027","journal-title":"Proc Natl Acad Sci USA"},{"key":"891_CR41","doi-asserted-by":"publisher","first-page":"2197","DOI":"10.1210\/en.2008-1149","volume":"150","author":"D Morgan","year":"2009","unstructured":"Morgan D, Rebelato E, Abdulkader F, Graciano MF, Oliveira-Emilio HR, Hirata AE, Rocha MS, Bordin S, Curi R, Carpinelli AR (2009) Association of NAD(P)H oxidase with glucose-induced insulin secretion by pancreatic beta-cells. Endocrinology 150:2197\u20132201","journal-title":"Endocrinology"},{"key":"891_CR42","doi-asserted-by":"publisher","first-page":"S53","DOI":"10.2337\/diabetes.51.2007.S53","volume":"51","author":"R Nesher","year":"2002","unstructured":"Nesher R, Cerasi E (2002) Modeling phasic insulin release: immediate and time-dependent effects of glucose. Diabetes 51:S53\u2013S59","journal-title":"Diabetes"},{"key":"891_CR43","doi-asserted-by":"publisher","first-page":"R105","DOI":"10.1530\/JOE-13-0616","volume":"221","author":"P Newsholme","year":"2014","unstructured":"Newsholme P, Cruzat V, Arfuso F, Keane K (2014) Nutrient regulation of insulin secretion and action. J Endocrinol 221:R105-120","journal-title":"J Endocrinol"},{"key":"891_CR44","doi-asserted-by":"publisher","first-page":"2273","DOI":"10.1083\/jcb.103.6.2273","volume":"103","author":"L Orci","year":"1986","unstructured":"Orci L, Ravazzola M, Amherdt M, Madsen O, Perrelet A, Vassalli JD, Anderson RG (1986) Conversion of proinsulin to insulin occurs coordinately with acidification of maturing secretory vesicles. J Cell Biol 103:2273\u20132281","journal-title":"J Cell Biol"},{"key":"891_CR45","doi-asserted-by":"publisher","first-page":"3601","DOI":"10.1074\/jbc.RA119.010489","volume":"295","author":"H Pang","year":"2020","unstructured":"Pang H, Wang X, Zhao S, Xi W, Lv J, Qin J, Zhao Q, Che Y, Chen L, Li SJ (2020) Loss of voltage-gated proton channel Hv1 decreases insulin secretion and leads to hyperglycemia and glucose intolerance in mice. J Biol Chem 295:3601\u20133613","journal-title":"J Biol Chem"},{"key":"891_CR46","doi-asserted-by":"publisher","first-page":"e000951","DOI":"10.1136\/bmjdrc-2019-000951","volume":"8","author":"H Pang","year":"2020","unstructured":"Pang H, Li J, Du H, Gao Y, Lv J, Liu Y, Li SJ (2020) Loss of voltage-gated proton channel Hv1 leads to diet-induced obesity in mice. BMJ Open Diabetes Res Care 8:e000951","journal-title":"BMJ Open Diabetes Res Care"},{"key":"891_CR47","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1152\/physiol.00005.2004","volume":"19","author":"P Paroutis","year":"2004","unstructured":"Paroutis P, Touret N, Grinstein S (2004) The pH of the secretory pathway: measurement, determinants, and regulation. Physiology 19:207\u2013215","journal-title":"Physiology"},{"key":"891_CR48","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1038\/nature13478","volume":"510","author":"RJ Perry","year":"2014","unstructured":"Perry RJ, Samuel VT, Petersen KF, Shulman GI (2014) The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes. Nature 510:84\u201391","journal-title":"Nature"},{"key":"891_CR49","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.ceca.2015.03.002","volume":"57","author":"FM Qureshi","year":"2015","unstructured":"Qureshi FM, Dejene EA, Corbin KL, Nunemaker CS (2015) Stress-induced dissociations between intracellular calcium signaling and insulin secretion in pancreatic islets. Cell Calcium 57:366\u2013375","journal-title":"Cell Calcium"},{"key":"891_CR50","doi-asserted-by":"publisher","first-page":"2424","DOI":"10.2337\/db11-1525","volume":"61","author":"L Ramalingam","year":"2012","unstructured":"Ramalingam L, Oh E, Yoder SM, Brozinick JT, Kalwat MA, Groffen AJ, Verhage M, Thurmond DC (2012) Doc2b is a key effector of insulin secretion and skeletal muscle insulin sensitivity. Diabetes 61:2424\u20132432","journal-title":"Diabetes"},{"key":"891_CR51","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1038\/nature04700","volume":"440","author":"IS Ramsey","year":"2006","unstructured":"Ramsey IS, Moran MM, Chong JA, Clapham DE (2006) A voltage-gated proton-selective channel lacking the pore domain. Nature 440:1213\u20131216","journal-title":"Nature"},{"key":"891_CR52","doi-asserted-by":"publisher","first-page":"7642","DOI":"10.1073\/pnas.0902761106","volume":"106","author":"IS Ramsey","year":"2009","unstructured":"Ramsey IS, Ruchti E, Kaczmarek JS, Clapham DE (2009) Hv1 proton channels are required for high-level NADPH oxidase-dependent superoxide production during the phagocyte respiratory burst. Proc Natl Acad Sci U S A 106:7642\u20137647","journal-title":"Proc Natl Acad Sci U S A"},{"key":"891_CR53","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1007\/s00125-003-1153-1","volume":"46","author":"P Rorsman","year":"2003","unstructured":"Rorsman P, Renstrom E (2003) Insulin granule dynamics in pancreatic beta cells. Diabetologia 46:1029\u20131045","journal-title":"Diabetologia"},{"key":"891_CR54","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1126\/science.1122352","volume":"312","author":"M Sasaki","year":"2006","unstructured":"Sasaki M, Takagi M, Okamura Y (2006) A voltage sensor-domain protein is a voltage-gated proton channel. Science 312:589\u2013592","journal-title":"Science"},{"key":"891_CR55","doi-asserted-by":"publisher","first-page":"438","DOI":"10.2337\/diab.41.4.438","volume":"41","author":"Y Sato","year":"1992","unstructured":"Sato Y, Aizawa T, Komatsu M, Okada N, Yamada T (1992) Dual functional role of membrane depolarization\/Ca2+ influx in rat pancreatic B-cell. Diabetes 41:438\u2013443","journal-title":"Diabetes"},{"key":"891_CR56","first-page":"451","volume":"125","author":"K Srinivasan","year":"2007","unstructured":"Srinivasan K, Ramarao P (2007) Animal models in type 2 diabetesresearch: an overview. Indian J Med Res 125:451\u2013472","journal-title":"Indian J Med Res"},{"key":"891_CR57","doi-asserted-by":"publisher","first-page":"40","DOI":"10.3389\/fendo.2013.00040","volume":"4","author":"DA Taylor-Fishwick","year":"2013","unstructured":"Taylor-Fishwick DA (2013) NOX, NOX Who is there? The contribution of NADPH oxidase one to beta cell dysfunction. Front Endocrinol (Lausanne) 4:40","journal-title":"Front Endocrinol (Lausanne)"},{"key":"891_CR58","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1038\/299826a0","volume":"299","author":"RC Thomas","year":"1982","unstructured":"Thomas RC, Meech RW (1982) Hydrogen ion currents and intracellular pH in depolarized voltage-clamped snail neurones. Nature 299:826\u2013828","journal-title":"Nature"},{"key":"891_CR59","doi-asserted-by":"publisher","first-page":"4832","DOI":"10.1210\/endo.139.12.6337","volume":"139","author":"KT Uysal","year":"1998","unstructured":"Uysal KT, Wiesbrock SM, Hotamisligil GS (1998) Functional analysis of tumor necrosis factor (TNF) receptors in TNF-alpha-mediated IR in genetic obesity. Endocrinology 139:4832\u20134838","journal-title":"Endocrinology"},{"key":"891_CR60","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1172\/JCI25102","volume":"115","author":"KE Wellen","year":"2005","unstructured":"Wellen KE, Hotamisligil GS (2005) Inflammation, stress, and diabetes. J Clin Invest 115:1111\u20131119","journal-title":"J Clin Invest"},{"key":"891_CR61","doi-asserted-by":"publisher","first-page":"33027","DOI":"10.1074\/jbc.M103917200","volume":"276","author":"MM Wu","year":"2001","unstructured":"Wu MM, Grabe M, Adams S, Tsien RY, Moore HP, Machen TE (2001) Mechanisms of pH regulation in the regulated secretory pathway. J Biol Chem 276:33027\u201333035","journal-title":"J Biol Chem"},{"key":"891_CR62","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1016\/j.bbrc.2015.11.027","volume":"468","author":"Q Zhao","year":"2015","unstructured":"Zhao Q, Che Y, Li Q, Zhang S, Gao YT, Wang Y, Wang X, Xi W, Zuo W, Li SJ (2015) The voltage-gated proton channel Hv1 is expressed in pancreatic islet \u03b2-cells and regulates insulin secretion. Biochem Biophys Res Commun 468:746\u2013751","journal-title":"Biochem Biophys Res Commun"}],"container-title":["Journal of Physiology and Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13105-022-00891-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13105-022-00891-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13105-022-00891-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T05:33:21Z","timestamp":1660628001000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13105-022-00891-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,30]]},"references-count":62,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["891"],"URL":"https:\/\/doi.org\/10.1007\/s13105-022-00891-8","relation":{},"ISSN":["1138-7548","1877-8755"],"issn-type":[{"value":"1138-7548","type":"print"},{"value":"1877-8755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,30]]},"assertion":[{"value":"15 October 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 March 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 March 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}