{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:35:10Z","timestamp":1791581710017,"version":"4.3.4"},"reference-count":94,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T00:00:00Z","timestamp":1657497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T00:00:00Z","timestamp":1657497600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160007"],"award-info":[{"award-number":["82160007"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008871","name":"Yunnan Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["2019FE001 (-058)"],"award-info":[{"award-number":["2019FE001 (-058)"]}],"id":[{"id":"10.13039\/501100008871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Physiol Biochem"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pyroptosis\nis commonly induced by the gasdermin (GSDM) family and is accompanied by the release of inflammatory cytokines such as IL-1\u03b2 and IL-18. Recently, increasing evidence suggests that pyroptosis plays a role in respiratory diseases. This review aimed to summarize the roles and mechanisms of pyroptosis in inflammation-related respiratory diseases. There are several pathways involved in pyroptosis, such as the canonical inflammasome-induced pathway, non-canonical inflammasome-induced pathway, caspase-1\/3\/6\/7\/GSDMB pathway, caspase-8\/GSDMC pathway, caspase-8\/GSDMD pathway, and caspase-3\/GSEME pathway. Pyroptosis may be involved in asthma, chronic obstructive pulmonary disease (COPD), lung cancer, acute lung injury (ALI), silicosis, pulmonary hypertension (PH), and tuberculosis (TB), in which the NLRP3 inflammasome-induced pathway is mostly highlighted. Pyroptosis contributes to the deterioration of asthma, COPD, ALI, silicosis, and PH. In addition, pyroptosis has dual effects on lung cancer and TB. Additionally, whether pyroptosis participates in cystic fibrosis (CF) and sarcoidosis or not is largely unknown, though the activation of NLRP3 inflammasome is found in CF and sarcoidosis. In conclusion, pyroptosis may play a role in inflammation-related respiratory diseases, providing new therapeutic targets.<\/jats:p>","DOI":"10.1007\/s13105-022-00909-1","type":"journal-article","created":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T08:34:01Z","timestamp":1657614841000},"page":"721-737","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":163,"title":["Pyroptosis in inflammation-related respiratory disease"],"prefix":"10.1007","volume":"78","author":[{"given":"Yuanyu","family":"Feng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoting","family":"Yangzhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xifeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anju","family":"Zu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunjiao","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9287-1820","authenticated-orcid":false,"given":"Shibo","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,7,11]]},"reference":[{"key":"909_CR1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1038\/s41420-018-0068-z","volume":"4","author":"A Balakrishnan","year":"2018","unstructured":"Balakrishnan A, Karki R, Berwin B, Yamamoto M, Kanneganti TD (2018) Guanylate binding proteins facilitate caspase-11-dependent pyroptosis in response to type 3 secretion system-negative Pseudomonas aeruginosa. Cell Death Discov 4:3. https:\/\/doi.org\/10.1038\/s41420-018-0068-z","journal-title":"Cell Death Discov"},{"key":"909_CR2","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1111\/resp.13695","volume":"24","author":"H Barnes","year":"2019","unstructured":"Barnes H, Goh NSL, Leong TL, Hoy R (2019) Silica-associated lung disease: an old-world exposure in modern industries. Respirology 24:1165\u20131175. https:\/\/doi.org\/10.1111\/resp.13695","journal-title":"Respirology"},{"key":"909_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2020.100863","volume":"76","author":"R Bauer","year":"2020","unstructured":"Bauer R, Rauch I (2020) The NAIP\/NLRC4 inflammasome in infection and pathology. Mol Aspects Med 76:100863. https:\/\/doi.org\/10.1016\/j.mam.2020.100863","journal-title":"Mol Aspects Med"},{"key":"909_CR4","doi-asserted-by":"publisher","first-page":"2270","DOI":"10.1038\/s41467-020-16143-6","volume":"11","author":"KS Beckwith","year":"2020","unstructured":"Beckwith KS, Beckwith MS, Ullmann S, S\u00e6tra RS, Kim H, Marstad A et al (2020) Plasma membrane damage causes NLRP3 activation and pyroptosis during Mycobacterium tuberculosis infection. Nat Commun 11:2270. https:\/\/doi.org\/10.1038\/s41467-020-16143-6","journal-title":"Nat Commun"},{"key":"909_CR5","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1001\/jama.2022.1570","volume":"327","author":"JA Belperio","year":"2022","unstructured":"Belperio JA, Shaikh F, Abtin FG, Fishbein MC, Weigt SS, Saggar R et al (2022) Diagnosis and treatment of pulmonary sarcoidosis: a review. JAMA 327:856\u2013867. https:\/\/doi.org\/10.1001\/jama.2022.1570","journal-title":"JAMA"},{"key":"909_CR6","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.824042","volume":"11","author":"L Biswas","year":"2021","unstructured":"Biswas L, G\u00f6tz F (2021) Molecular mechanisms of Staphylococcus and Pseudomonas interactions in cystic fibrosis. Front Cell Infect Microbiol 11:824042. https:\/\/doi.org\/10.3389\/fcimb.2021.824042","journal-title":"Front Cell Infect Microbiol"},{"key":"909_CR7","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.prostaglandins.2018.08.001","volume":"138","author":"Y Cao","year":"2018","unstructured":"Cao Y, Zhou X, Yin Z, Yu X, Yang Q, Guo Q et al (2018) The anti-inflammatory effect of BML-111 on COPD may be mediated by regulating NLRP3 inflammasome activation and ROS production. Prostaglandins Other Lipid Mediat 138:23\u201330. https:\/\/doi.org\/10.1016\/j.prostaglandins.2018.08.001","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"909_CR8","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1164\/rccm.200905-0696OC","volume":"181","author":"ES Chen","year":"2010","unstructured":"Chen ES, Song Z, Willett MH, Heine S, Yung RC, Liu MC et al (2010) Serum amyloid A regulates granulomatous inflammation in sarcoidosis through Toll-like receptor-2. Am J Respir Crit Care Med 181:360\u2013373. https:\/\/doi.org\/10.1164\/rccm.200905-0696OC","journal-title":"Am J Respir Crit Care Med"},{"key":"909_CR9","doi-asserted-by":"publisher","first-page":"4124","DOI":"10.1172\/jci94495","volume":"127","author":"KT Cheng","year":"2017","unstructured":"Cheng KT, Xiong S, Ye Z, Hong Z, Di A, Tsang KM et al (2017) Caspase-11-mediated endothelial pyroptosis underlies endotoxemia-induced lung injury. J Clin Invest 127:4124\u20134135. https:\/\/doi.org\/10.1172\/jci94495","journal-title":"J Clin Invest"},{"key":"909_CR10","doi-asserted-by":"publisher","first-page":"426","DOI":"10.3390\/cells10020436","volume":"10","author":"P Cheng","year":"2021","unstructured":"Cheng P, Li S, Chen H (2021) Macrophages in lung injury, repair, and fibrosis. Cells 10:426. https:\/\/doi.org\/10.3390\/cells10020436","journal-title":"Cells"},{"key":"909_CR11","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1093\/jmcb\/mjy056","volume":"11","author":"Q Chen","year":"2019","unstructured":"Chen Q, Shi P, Wang Y, Zou D, Wu X, Wang D et al (2019) GSDMB promotes non-canonical pyroptosis by enhancing caspase-4 activity. J Mol Cell Biol 11:496\u2013508. https:\/\/doi.org\/10.1093\/jmcb\/mjy056","journal-title":"J Mol Cell Biol"},{"key":"909_CR12","doi-asserted-by":"publisher","first-page":"2217","DOI":"10.1007\/s10753-021-01494-z","volume":"44","author":"X Chen","year":"2021","unstructured":"Chen X, Xiao Z, Jiang Z, Jiang Y, Li W, Wang M (2021) Schisandrin B attenuates airway inflammation and airway remodeling in asthma by inhibiting NLRP3 inflammasome activation and reducing pyroptosis. Inflammation 44:2217\u20132231. https:\/\/doi.org\/10.1007\/s10753-021-01494-z","journal-title":"Inflammation"},{"key":"909_CR13","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.18632\/oncotarget.27964","volume":"12","author":"C Colarusso","year":"2021","unstructured":"Colarusso C, Terlizzi M, Lamort AS, Cerqua I, Roviezzo F, Stathopoulos G et al (2021) Caspase-11 and AIM2 inflammasome are involved in smoking-induced COPD and lung adenocarcinoma. Oncotarget 12:1057\u20131071. https:\/\/doi.org\/10.18632\/oncotarget.27964","journal-title":"Oncotarget"},{"key":"909_CR14","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/s0966-842x(00)01936-3","volume":"9","author":"BT Cookson","year":"2001","unstructured":"Cookson BT, Brennan MA (2001) Pro-inflammatory programmed cell death. Trends Microbiol 9:113\u2013114. https:\/\/doi.org\/10.1016\/s0966-842x(00)01936-3","journal-title":"Trends Microbiol"},{"key":"909_CR15","doi-asserted-by":"publisher","first-page":"13132","DOI":"10.1073\/pnas.1610433113","volume":"113","author":"S Das","year":"2016","unstructured":"Das S, Miller M, Beppu AK, Mueller J, McGeough MD, Vuong C et al (2016) GSDMB induces an asthma phenotype characterized by increased airway responsiveness and remodeling without lung inflammation. Proc Natl Acad Sci U S A 113:13132\u201313137. https:\/\/doi.org\/10.1073\/pnas.1610433113","journal-title":"Proc Natl Acad Sci U S A"},{"key":"909_CR16","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1038\/s41586-021-04384-4","volume":"602","author":"W Deng","year":"2022","unstructured":"Deng W, Bai Y, Deng F, Pan Y, Mei S, Zheng Z et al (2022) Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis. Nature 602:496\u2013502. https:\/\/doi.org\/10.1038\/s41586-021-04384-4","journal-title":"Nature"},{"key":"909_CR17","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.jaci.2017.09.035","volume":"142","author":"MD Evans","year":"2018","unstructured":"Evans MD, Esnault S, Denlinger LC, Jarjour NN (2018) Sputum cell IL-1 receptor expression level is a marker of airway neutrophilia and airflow obstruction in asthmatic patients. J Allergy Clin Immunol 142:415\u2013423. https:\/\/doi.org\/10.1016\/j.jaci.2017.09.035","journal-title":"J Allergy Clin Immunol"},{"key":"909_CR18","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/s41418-018-0212-6","volume":"26","author":"D Frank","year":"2019","unstructured":"Frank D, Vince JE (2019) Pyroptosis versus necroptosis: similarities, differences, and crosstalk. Cell Death Differ 26:99\u2013114. https:\/\/doi.org\/10.1038\/s41418-018-0212-6","journal-title":"Cell Death Differ"},{"key":"909_CR19","doi-asserted-by":"publisher","first-page":"1805147","DOI":"10.1155\/2021\/1805147","volume":"2021","author":"Y Fu","year":"2021","unstructured":"Fu Y, Shen J, Li Y, Liu F, Ning B, Zheng Y et al (2021) Inhibition of the PERK\/TXNIP\/NLRP3 axis by baicalin reduces NLRP3 inflammasome-mediated pyroptosis in macrophages infected with Mycobacterium tuberculosis. Mediators Inflamm 2021:1805147. https:\/\/doi.org\/10.1155\/2021\/1805147","journal-title":"Mediators Inflamm"},{"key":"909_CR20","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1164\/rccm.202106-1426OC","volume":"205","author":"C Gabillard-Lefort","year":"2022","unstructured":"Gabillard-Lefort C, Casey M, Glasgow AMA, Boland F, Kerr O, Marron E et al (2022) Trikafta rescues CFTR and lowers monocyte P2X7R-induced inflammasome activation in cystic fibrosis. Am J Respir Crit Care Med 205:783\u2013794. https:\/\/doi.org\/10.1164\/rccm.202106-1426OC","journal-title":"Am J Respir Crit Care Med"},{"key":"909_CR21","doi-asserted-by":"publisher","first-page":"1971","DOI":"10.3892\/or.2018.6634","volume":"40","author":"J Gao","year":"2018","unstructured":"Gao J, Qiu X, Xi G, Liu H, Zhang F, Lv T et al (2018) Downregulation of GSDMD attenuates tumor proliferation via the intrinsic mitochondrial apoptotic pathway and inhibition of EGFR\/Akt signaling and predicts a good prognosis in non-small cell lung cancer. Oncol Rep 40:1971\u20131984. https:\/\/doi.org\/10.3892\/or.2018.6634","journal-title":"Oncol Rep"},{"key":"909_CR22","doi-asserted-by":"publisher","first-page":"L472","DOI":"10.1152\/ajplung.00405.2019","volume":"318","author":"S He","year":"2020","unstructured":"He S, Ma C, Zhang L et al (2020) GLI1-mediated pulmonary artery smooth muscle cell pyroptosis contributes to hypoxia-induced pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol 318:L472-l482. https:\/\/doi.org\/10.1152\/ajplung.00405.2019","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"909_CR23","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1038\/nature16959","volume":"530","author":"Y He","year":"2016","unstructured":"He Y, Zeng MY, Yang D, Motro B, N\u00fa\u00f1ez G (2016) NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux. Nature 530:354\u2013357. https:\/\/doi.org\/10.1038\/nature16959","journal-title":"Nature"},{"key":"909_CR24","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.1038\/s41556-020-0575-z","volume":"22","author":"J Hou","year":"2020","unstructured":"Hou J, Zhao R, Xia W, Chang CW, You Y, Hsu JM et al (2020) PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis. Nat Cell Biol 22:1264\u20131275. https:\/\/doi.org\/10.1038\/s41556-020-0575-z","journal-title":"Nat Cell Biol"},{"key":"909_CR25","first-page":"4287","volume":"10","author":"Z Huang","year":"2020","unstructured":"Huang Z, Zhang Q, Wang Y, Chen R, Wang Y, Huang Z et al (2020) Inhibition of caspase-3-mediated GSDME-derived pyroptosis aids in noncancerous tissue protection of squamous cell carcinoma patients during cisplatin-based chemotherapy. Am J Cancer Res 10:4287\u20134307","journal-title":"Am J Cancer Res"},{"key":"909_CR26","doi-asserted-by":"publisher","first-page":"1900119","DOI":"10.1183\/13993003.00119-2019","volume":"55","author":"C Huppertz","year":"2020","unstructured":"Huppertz C, J\u00e4ger B, Wieczorek G, Engelhard P, Oliver SJ, Bauernfeind FG et al (2020) The NLRP3 inflammasome pathway is activated in sarcoidosis and involved in granuloma formation. Eur Respir J 55:1900119. https:\/\/doi.org\/10.1183\/13993003.00119-2019","journal-title":"Eur Respir J"},{"key":"909_CR27","doi-asserted-by":"publisher","first-page":"680512","DOI":"10.3389\/fphar.2021.680512","volume":"12","author":"R Jiang","year":"2021","unstructured":"Jiang R, Xu J, Zhang Y, Zhu X, Liu J, Tan Y (2021) Ligustrazine alleviate acute lung injury through suppressing pyroptosis and apoptosis of alveolar macrophages. Front Pharmacol 12:680512. https:\/\/doi.org\/10.3389\/fphar.2021.680512","journal-title":"Front Pharmacol"},{"key":"909_CR28","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1038\/nature15541","volume":"526","author":"N Kayagaki","year":"2015","unstructured":"Kayagaki N, Stowe IB, Lee BL, O\u2019Rourke K, Anderson K, Warming S et al (2015) Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling. Nature 526:666\u2013671. https:\/\/doi.org\/10.1038\/nature15541","journal-title":"Nature"},{"key":"909_CR29","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1146\/annurev-immunol-073119-095439","volume":"38","author":"S Kesavardhana","year":"2020","unstructured":"Kesavardhana S, Malireddi RKS, Kanneganti TD (2020) Caspases in cell death, inflammation, and pyroptosis. Annu Rev Immunol 38:567\u2013595. https:\/\/doi.org\/10.1146\/annurev-immunol-073119-095439","journal-title":"Annu Rev Immunol"},{"key":"909_CR30","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1164\/rccm.201609-1830OC","volume":"196","author":"RY Kim","year":"2017","unstructured":"Kim RY, Pinkerton JW, Essilfie AT, Robertson AAB, Baines KJ, Brown AC et al (2017) Role for NLRP3 inflammasome-mediated, IL-1\u03b2-dependent responses in severe, steroid-resistant asthma. Am J Respir Crit Care Med 196:283\u2013297. https:\/\/doi.org\/10.1164\/rccm.201609-1830OC","journal-title":"Am J Respir Crit Care Med"},{"key":"909_CR31","doi-asserted-by":"publisher","first-page":"7501","DOI":"10.1007\/s13277-015-3473-4","volume":"36","author":"H Kong","year":"2015","unstructured":"Kong H, Wang Y, Zeng X, Wang Z, Wang H, Xie W (2015) Differential expression of inflammasomes in lung cancer cell lines and tissues. Tumour Biol 36:7501\u20137513. https:\/\/doi.org\/10.1007\/s13277-015-3473-4","journal-title":"Tumour Biol"},{"key":"909_CR32","doi-asserted-by":"publisher","first-page":"2006","DOI":"10.4049\/jimmunol.1201065","volume":"189","author":"M Kovarova","year":"2012","unstructured":"Kovarova M, Hesker PR, Jania L, Nguyen M, Snouwaert JN, Xiang Z et al (2012) NLRP1-dependent pyroptosis leads to acute lung injury and morbidity in mice. J Immunol 189:2006\u20132016. https:\/\/doi.org\/10.4049\/jimmunol.1201065","journal-title":"J Immunol"},{"key":"909_CR33","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1016\/j.cell.2014.04.007","volume":"157","author":"M Lamkanfi","year":"2014","unstructured":"Lamkanfi M, Dixit VM (2014) Mechanisms and functions of inflammasomes. Cell 157:1013\u20131022. https:\/\/doi.org\/10.1016\/j.cell.2014.04.007","journal-title":"Cell"},{"key":"909_CR34","doi-asserted-by":"publisher","first-page":"2008","DOI":"10.1016\/s0140-6736(12)60235-9","volume":"379","author":"CC Leung","year":"2012","unstructured":"Leung CC, Yu IT, Chen W (2012) Silicosis Lancet 379:2008\u20132018. https:\/\/doi.org\/10.1016\/s0140-6736(12)60235-9","journal-title":"Silicosis Lancet"},{"key":"909_CR35","doi-asserted-by":"publisher","first-page":"4399","DOI":"10.3892\/mmr.2018.9427","volume":"18","author":"D Li","year":"2018","unstructured":"Li D, Ren W, Jiang Z, Zhu L (2018) Regulation of the NLRP3 inflammasome and macrophage pyroptosis by the p38 MAPK signaling pathway in a mouse model of acute lung injury. Mol Med Rep 18:4399\u20134409. https:\/\/doi.org\/10.3892\/mmr.2018.9427","journal-title":"Mol Med Rep"},{"key":"909_CR36","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1042\/cs20211156","volume":"136","author":"B Liu","year":"2022","unstructured":"Liu B, Wang Z, He R, Xiong R, Li G, Zhang L et al (2022) Buformin alleviates sepsis-induced acute lung injury via inhibiting NLRP3-mediated pyroptosis through an AMPK-dependent pathway. Clin Sci (Lond) 136:273\u2013289. https:\/\/doi.org\/10.1042\/cs20211156","journal-title":"Clin Sci (Lond)"},{"key":"909_CR37","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2021.107839","volume":"225","author":"G Liu","year":"2021","unstructured":"Liu G, Philp AM, Corte T, Travis MA, Schilter H, Hansbro NG et al (2021) Therapeutic targets in lung tissue remodelling and fibrosis. Pharmacol Ther 225:107839. https:\/\/doi.org\/10.1016\/j.pharmthera.2021.107839","journal-title":"Pharmacol Ther"},{"key":"909_CR38","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1038\/nature18629","volume":"535","author":"X Liu","year":"2016","unstructured":"Liu X, Zhang Z, Ruan J, Pan Y, Magupalli VG, Wu H et al (2016) Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores. Nature 535:153\u2013158. https:\/\/doi.org\/10.1038\/nature18629","journal-title":"Nature"},{"key":"909_CR39","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1016\/j.jaci.2020.07.030","volume":"147","author":"X Li","year":"2021","unstructured":"Li X, Christenson SA, Modena B, Li H, Busse WW, Castro M et al (2021) Genetic analyses identify GSDMB associated with asthma severity, exacerbations, and antiviral pathways. J Allergy Clin Immunol 147:894\u2013909. https:\/\/doi.org\/10.1016\/j.jaci.2020.07.030","journal-title":"J Allergy Clin Immunol"},{"key":"909_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.114595","volume":"282","author":"Y Li","year":"2022","unstructured":"Li Y, Fu Y, Sun J, Shen J, Liu F, Ning B et al (2022) Tanshinone IIA alleviates NLRP3 inflammasome-mediated pyroptosis in Mycobacterium tuberculosis-(H37Ra-) infected macrophages by inhibiting endoplasmic reticulum stress. J Ethnopharmacol 282:114595. https:\/\/doi.org\/10.1016\/j.jep.2021.114595","journal-title":"J Ethnopharmacol"},{"key":"909_CR41","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2020.111588","volume":"144","author":"S Mahalanobish","year":"2020","unstructured":"Mahalanobish S, Dutta S, Saha S, Sil PC (2020) Melatonin induced suppression of ER stress and mitochondrial dysfunction inhibited NLRP3 inflammasome activation in COPD mice. Food Chem Toxicol 144:111588. https:\/\/doi.org\/10.1016\/j.fct.2020.111588","journal-title":"Food Chem Toxicol"},{"issue":"Suppl 27","key":"909_CR42","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1111\/pai.13619","volume":"33","author":"S Manti","year":"2022","unstructured":"Manti S, Parisi GF, Papale M, Marseglia GL, Licari A, Leonardi S (2022) Type 2 inflammation in cystic fibrosis: new insights. Pediatr Allergy Immunol 33(Suppl 27):15\u201317. https:\/\/doi.org\/10.1111\/pai.13619","journal-title":"Pediatr Allergy Immunol"},{"key":"909_CR43","doi-asserted-by":"publisher","first-page":"3063","DOI":"10.4049\/jimmunol.2000373","volume":"204","author":"S Matikainen","year":"2020","unstructured":"Matikainen S, Nyman TA, Cypryk W (2020) Function and regulation of noncanonical caspase-4\/5\/11 inflammasome. J Immunol 204:3063\u20133069. https:\/\/doi.org\/10.4049\/jimmunol.2000373","journal-title":"J Immunol"},{"key":"909_CR44","doi-asserted-by":"publisher","first-page":"2731","DOI":"10.1172\/jci60331","volume":"122","author":"MA Matthay","year":"2012","unstructured":"Matthay MA, Ware LB, Zimmerman GA (2012) The acute respiratory distress syndrome. J Clin Invest 122:2731\u20134270. https:\/\/doi.org\/10.1172\/jci60331","journal-title":"J Clin Invest"},{"key":"909_CR45","doi-asserted-by":"publisher","first-page":"379","DOI":"10.3390\/ijms21020379","volume":"21","author":"L Mazgaeen","year":"2020","unstructured":"Mazgaeen L, Gurung P (2020) Recent advances in lipopolysaccharide recognition systems. Int J Mol Sci 21:379. https:\/\/doi.org\/10.3390\/ijms21020379","journal-title":"Int J Mol Sci"},{"key":"909_CR46","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.coi.2019.04.015","volume":"60","author":"PS Mitchell","year":"2019","unstructured":"Mitchell PS, Sandstrom A, Vance RE (2019) The NLRP1 inflammasome: new mechanistic insights and unresolved mysteries. Curr Opin Immunol 60:37\u201345. https:\/\/doi.org\/10.1016\/j.coi.2019.04.015","journal-title":"Curr Opin Immunol"},{"key":"909_CR47","doi-asserted-by":"publisher","first-page":"92","DOI":"10.3892\/mmr.2022.12608","volume":"25","author":"R Mo","year":"2022","unstructured":"Mo R, Zhang J, Chen Y, Ding Y (2022) Nicotine promotes chronic obstructive pulmonary disease via inducing pyroptosis activation in bronchial epithelial cells. Mol Med Rep 25:92. https:\/\/doi.org\/10.3892\/mmr.2022.12608","journal-title":"Mol Med Rep"},{"key":"909_CR48","doi-asserted-by":"publisher","DOI":"10.1002\/bies.201900086","volume":"41","author":"KC Patterson","year":"2019","unstructured":"Patterson KC, Queval CJ, Gutierrez MG (2019) Granulomatous inflammation in tuberculosis and sarcoidosis: does the lymphatic system contribute to disease? BioEssays 41:e1900086. https:\/\/doi.org\/10.1002\/bies.201900086","journal-title":"BioEssays"},{"key":"909_CR49","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1038\/s41392-020-00274-9","volume":"5","author":"Z Peng","year":"2020","unstructured":"Peng Z, Wang P, Song W, Yao Q, Li Y, Liu L et al (2020) GSDME enhances cisplatin sensitivity to regress non-small cell lung carcinoma by mediating pyroptosis to trigger antitumor immunocyte infiltration. Signal Transduct Target Ther 5:159. https:\/\/doi.org\/10.1038\/s41392-020-00274-9","journal-title":"Signal Transduct Target Ther"},{"key":"909_CR50","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/s12931-022-01937-7","volume":"23","author":"K Peukert","year":"2022","unstructured":"Peukert K, Steinhagen F, Fox M, Feuerborn C, Schulz S, Seeliger B et al (2022) Tetracycline ameliorates silica-induced pulmonary inflammation and fibrosis via inhibition of caspase-1. Respir Res 23:21. https:\/\/doi.org\/10.1186\/s12931-022-01937-7","journal-title":"Respir Res"},{"key":"909_CR51","doi-asserted-by":"publisher","first-page":"97","DOI":"10.3389\/fimmu.2016.00097","volume":"7","author":"KM Pollard","year":"2016","unstructured":"Pollard KM (2016) Silica, Silicosis, and Autoimmunity. Front Immunol 7:97. https:\/\/doi.org\/10.3389\/fimmu.2016.00097","journal-title":"Front Immunol"},{"key":"909_CR52","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.7150\/ijbs.66477","volume":"18","author":"X Qin","year":"2022","unstructured":"Qin X, Zhou Y, Jia C, Chao Z, Qin H, Liang J et al (2022) Caspase-1-mediated extracellular vesicles derived from pyroptotic alveolar macrophages promote inflammation in acute lung injury. Int J Biol Sci 18:1521\u20131538. https:\/\/doi.org\/10.7150\/ijbs.66477","journal-title":"Int J Biol Sci"},{"key":"909_CR53","doi-asserted-by":"publisher","first-page":"eaba4733","DOI":"10.1126\/sciadv.aba4733","volume":"6","author":"Z Qu","year":"2020","unstructured":"Qu Z, Zhou J, Zhou Y, Xie Y, Jiang Y, Wu J et al (2020) Mycobacterial EST12 activates a RACK1-NLRP3-gasdermin D pyroptosis-IL-1\u03b2 immune pathway. Sci Adv 6:eaba4733. https:\/\/doi.org\/10.1126\/sciadv.aba4733","journal-title":"Sci Adv"},{"key":"909_CR54","doi-asserted-by":"publisher","first-page":"791136","DOI":"10.3389\/fimmu.2022.791136","volume":"13","author":"S Rastogi","year":"2022","unstructured":"Rastogi S, Briken V (2022) Interaction of mycobacteria with host cell inflammasomes. Front Immunol 13:791136. https:\/\/doi.org\/10.3389\/fimmu.2022.791136","journal-title":"Front Immunol"},{"key":"909_CR55","doi-asserted-by":"publisher","first-page":"e1009712","DOI":"10.1371\/journal.ppat.1009712","volume":"17","author":"S Rastogi","year":"2021","unstructured":"Rastogi S, Ellinwood S, Augenstreich J, Mayer-Barber KD, Briken V (2021) Mycobacterium tuberculosis inhibits the NLRP3 inflammasome activation via its phosphokinase PknF. PLoS Pathog 17:e1009712. https:\/\/doi.org\/10.1371\/journal.ppat.1009712","journal-title":"PLoS Pathog"},{"key":"909_CR56","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1016\/j.cell.2016.03.046","volume":"165","author":"VA Rathinam","year":"2016","unstructured":"Rathinam VA, Fitzgerald KA (2016) Inflammasome complexes: emerging mechanisms and effector functions. Cell 165:792\u2013800. https:\/\/doi.org\/10.1016\/j.cell.2016.03.046","journal-title":"Cell"},{"key":"909_CR57","doi-asserted-by":"publisher","first-page":"109052","DOI":"10.1016\/j.cbi.2020.109052","volume":"323","author":"J Ruan","year":"2020","unstructured":"Ruan J, Wang S, Wang J (2020) Mechanism and regulation of pyroptosis-mediated in cancer cell death. Chem Biol Interact 323:109052. https:\/\/doi.org\/10.1016\/j.cbi.2020.109052","journal-title":"Chem Biol Interact"},{"key":"909_CR58","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1093\/intimm\/dxs062","volume":"24","author":"H Saiga","year":"2012","unstructured":"Saiga H, Kitada S, Shimada Y, Kamiyama N, Okuyama M, Makino M et al (2012) Critical role of AIM2 in Mycobacterium tuberculosis infection. Int Immunol 24:637\u2013644. https:\/\/doi.org\/10.1093\/intimm\/dxs062","journal-title":"Int Immunol"},{"key":"909_CR59","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.trsl.2017.09.002","volume":"191","author":"A Saradna","year":"2018","unstructured":"Saradna A, Do DC, Kumar S, Fu QL, Gao P (2018) Macrophage polarization and allergic asthma. Transl Res 191:1\u201314. https:\/\/doi.org\/10.1016\/j.trsl.2017.09.002","journal-title":"Transl Res"},{"key":"909_CR60","doi-asserted-by":"publisher","first-page":"E10888","DOI":"10.1073\/pnas.1809548115","volume":"115","author":"J Sarhan","year":"2018","unstructured":"Sarhan J, Liu BC, Muendlein HI, Li P, Nilson R, Tang AY et al (2018) Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection. Proc Natl Acad Sci U S A 115:E10888-e10897. https:\/\/doi.org\/10.1073\/pnas.1809548115","journal-title":"Proc Natl Acad Sci U S A"},{"key":"909_CR61","doi-asserted-by":"publisher","first-page":"e49248","DOI":"10.7554\/eLife.49248","volume":"8","author":"T Scambler","year":"2019","unstructured":"Scambler T, Jarosz-Griffiths HH, Lara-Reyna S, Pathak S, Wong C, Holbrook J et al (2019) ENaC-mediated sodium influx exacerbates NLRP3-dependent inflammation in cystic fibrosis. Elife 8:e49248. https:\/\/doi.org\/10.7554\/eLife.49248","journal-title":"Elife"},{"key":"909_CR62","doi-asserted-by":"publisher","first-page":"3514","DOI":"10.4049\/jimmunol.1301331","volume":"191","author":"S Shah","year":"2013","unstructured":"Shah S, Bohsali A, Ahlbrand SE, Srinivasan L, Rathinam VA, Vogel SN et al (2013) Cutting edge: Mycobacterium tuberculosis but not nonvirulent mycobacteria inhibits IFN-\u03b2 and AIM2 inflammasome-dependent IL-1\u03b2 production via its ESX-1 secretion system. J Immunol 191:3514\u20133518. https:\/\/doi.org\/10.4049\/jimmunol.1301331","journal-title":"J Immunol"},{"key":"909_CR63","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.tibs.2016.10.004","volume":"42","author":"J Shi","year":"2017","unstructured":"Shi J, Gao W, Shao F (2017) Pyroptosis: gasdermin-mediated programmed necrotic cell death. Trends Biochem Sci 42:245\u2013254. https:\/\/doi.org\/10.1016\/j.tibs.2016.10.004","journal-title":"Trends Biochem Sci"},{"key":"909_CR64","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21551","volume":"69","author":"RL Siegel","year":"2019","unstructured":"Siegel RL, Miller KD, Jemal A (2019) Cancer statistics, 2019. CA Cancer J Clin 69:7\u201334. https:\/\/doi.org\/10.3322\/caac.21551","journal-title":"CA Cancer J Clin"},{"key":"909_CR65","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.824165","volume":"10","author":"D Song","year":"2022","unstructured":"Song D, Li M, Yu X, Wang Y, Fan J, Yang W et al (2022) The molecular pathways of pyroptosis in atherosclerosis. Front Cell Dev Biol 10:824165. https:\/\/doi.org\/10.3389\/fcell.2022.824165","journal-title":"Front Cell Dev Biol"},{"key":"909_CR66","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1016\/j.apsb.2021.10.006","volume":"12","author":"M Song","year":"2022","unstructured":"Song M, Wang J, Sun Y, Pang J, Li X, Liu Y et al (2022) Inhibition of gasdermin D-dependent pyroptosis attenuates the progression of silica-induced pulmonary inflammation and fibrosis. Acta Pharm Sin B 12:1213\u20131224. https:\/\/doi.org\/10.1016\/j.apsb.2021.10.006","journal-title":"Acta Pharm Sin B"},{"key":"909_CR67","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s00281-020-00785-1","volume":"42","author":"J Stern","year":"2020","unstructured":"Stern J, Pier J, Litonjua AA (2020) Asthma epidemiology and risk factors. Semin Immunopathol 42:5\u201315. https:\/\/doi.org\/10.1007\/s00281-020-00785-1","journal-title":"Semin Immunopathol"},{"key":"909_CR68","doi-asserted-by":"publisher","first-page":"193","DOI":"10.3390\/cancers12010193","volume":"12","author":"JF Teng","year":"2020","unstructured":"Teng JF, Mei QB, Zhou XG, Tang Y, Xiong R, Qiu WQ et al (2020) Polyphyllin VI induces caspase-1-mediated pyroptosis via the induction of ROS\/NF-\u03baB\/NLRP3\/GSDMD signal axis in non-small cell lung cancer. Cancers (Basel) 12:193. https:\/\/doi.org\/10.3390\/cancers12010193","journal-title":"Cancers (Basel)"},{"key":"909_CR69","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j5492","volume":"360","author":"T Thenappan","year":"2018","unstructured":"Thenappan T, Ormiston ML, Ryan JJ, Archer SL (2018) Pulmonary arterial hypertension: pathogenesis and clinical management. BMJ 360:j5492. https:\/\/doi.org\/10.1136\/bmj.j5492","journal-title":"BMJ"},{"key":"909_CR70","doi-asserted-by":"publisher","first-page":"757","DOI":"10.3892\/ijmm.2017.3310","volume":"41","author":"YM Tsai","year":"2018","unstructured":"Tsai YM, Chiang KH, Hung JY, Chang WA, Lin HP, Shieh JM et al (2018) Der f1 induces pyroptosis in human bronchial epithelia via the NLRP3 inflammasome. Int J Mol Med 41:757\u2013764. https:\/\/doi.org\/10.3892\/ijmm.2017.3310","journal-title":"Int J Mol Med"},{"key":"909_CR71","doi-asserted-by":"publisher","first-page":"L999","DOI":"10.1152\/ajplung.00322.2018","volume":"316","author":"C Udjus","year":"2019","unstructured":"Udjus C, Cero FT, Halvorsen B, Behmen D, Carlson CR, Bendiksen BA et al (2019) Caspase-1 induces smooth muscle cell growth in hypoxia-induced pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol 316:L999\u2013L1012. https:\/\/doi.org\/10.1152\/ajplung.00322.2018","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"909_CR72","doi-asserted-by":"publisher","first-page":"1638","DOI":"10.1002\/jcp.30008","volume":"236","author":"A Vecchi\u00e9","year":"2021","unstructured":"Vecchi\u00e9 A, Bonaventura A, Toldo S, Dagna L, Dinarello CA, Abbate A (2021) IL-18 and infections: is there a role for targeted therapies? J Cell Physiol 236:1638\u20131657. https:\/\/doi.org\/10.1002\/jcp.30008","journal-title":"J Cell Physiol"},{"key":"909_CR73","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2021.167297","volume":"434","author":"C Wang","year":"2022","unstructured":"Wang C, Ruan J (2022) Mechanistic insights into gasdermin pore formation and regulation in pyroptosis. J Mol Biol 434:167297. https:\/\/doi.org\/10.1016\/j.jmb.2021.167297","journal-title":"J Mol Biol"},{"key":"909_CR74","doi-asserted-by":"publisher","first-page":"56","DOI":"10.3892\/ijmm.2022.5112","volume":"49","author":"L Wang","year":"2022","unstructured":"Wang L, Meng J, Wang C, Wang Y, Yang C, Li Y (2022) Hydrogen sulfide attenuates cigarette smoke-induced pyroptosis through the TLR4\/NF-\u03baB signaling pathway. Int J Mol Med 49:56. https:\/\/doi.org\/10.3892\/ijmm.2022.5112","journal-title":"Int J Mol Med"},{"key":"909_CR75","doi-asserted-by":"publisher","first-page":"2915","DOI":"10.1038\/s41467-021-23201-0","volume":"12","author":"LQ Wang","year":"2021","unstructured":"Wang LQ, Liu T, Yang S, Sun L, Zhao ZY, Li LY et al (2021) Perfluoroalkyl substance pollutants activate the innate immune system through the AIM2 inflammasome. Nat Commun 12:2915. https:\/\/doi.org\/10.1038\/s41467-021-23201-0","journal-title":"Nat Commun"},{"key":"909_CR76","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1186\/s12915-020-00918-w","volume":"18","author":"W Wang","year":"2020","unstructured":"Wang W, Hu D, Feng Y, Wu C, Song Y, Liu W et al (2020) Paxillin mediates ATP-induced activation of P2X7 receptor and NLRP3 inflammasome. BMC Biol 18:182. https:\/\/doi.org\/10.1186\/s12915-020-00918-w","journal-title":"BMC Biol"},{"key":"909_CR77","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/nature22393","volume":"547","author":"Y Wang","year":"2017","unstructured":"Wang Y, Gao W, Shi X, Ding J, Liu W, He H et al (2017) Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin. Nature 547:99\u2013103. https:\/\/doi.org\/10.1038\/nature22393","journal-title":"Nature"},{"key":"909_CR78","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1161\/hypertensionaha.121.17868","volume":"79","author":"Y Wu","year":"2022","unstructured":"Wu Y, Pan B, Zhang Z, Li X, Leng Y, Ji Y et al (2022) Caspase-4\/11-mediated pulmonary artery endothelial cell pyroptosis contributes to pulmonary arterial hypertension. Hypertension 79:536\u2013548. https:\/\/doi.org\/10.1161\/hypertensionaha.121.17868","journal-title":"Hypertension"},{"key":"909_CR79","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1038\/s41419-019-1883-8","volume":"10","author":"X Xia","year":"2019","unstructured":"Xia X, Wang X, Cheng Z, Qin W, Lei L, Jiang J et al (2019) The role of pyroptosis in cancer: pro-cancer or pro-\u201chost\u201d? Cell Death Dis 10:650. https:\/\/doi.org\/10.1038\/s41419-019-1883-8","journal-title":"Cell Death Dis"},{"key":"909_CR80","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1038\/s41419-019-1413-8","volume":"10","author":"Y Yang","year":"2019","unstructured":"Yang Y, Wang H, Kouadir M, Song H, Shi F (2019) Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors. Cell Death Dis 10:128. https:\/\/doi.org\/10.1038\/s41419-019-1413-8","journal-title":"Cell Death Dis"},{"key":"909_CR81","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1016\/j.biopha.2019.01.018","volume":"111","author":"Y Yao","year":"2019","unstructured":"Yao Y, Zhou D, Shi D, Zhang H, Zhan S, Shao X et al (2019) GLI1 overexpression promotes gastric cancer cell proliferation and migration and induces drug resistance by combining with the AKT-mTOR pathway. Biomed Pharmacother 111:993\u20131004. https:\/\/doi.org\/10.1016\/j.biopha.2019.01.018","journal-title":"Biomed Pharmacother"},{"key":"909_CR82","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1016\/j.omtn.2019.08.028","volume":"18","author":"Y Ying","year":"2019","unstructured":"Ying Y, Mao Y, Yao M (2019) NLRP3 inflammasome activation by microRNA-495 promoter methylation may contribute to the progression of acute lung injury. Mol Ther Nucleic Acids 18:801\u2013814. https:\/\/doi.org\/10.1016\/j.omtn.2019.08.028","journal-title":"Mol Ther Nucleic Acids"},{"key":"909_CR83","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.874459","volume":"13","author":"H Yin","year":"2022","unstructured":"Yin H, Fang L, Wang L, Xia Y, Tian J, Ma L et al (2022) Acute silica exposure triggers pulmonary inflammation through macrophage pyroptosis: an experimental simulation. Front Immunol 13:874459. https:\/\/doi.org\/10.3389\/fimmu.2022.874459","journal-title":"Front Immunol"},{"key":"909_CR84","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1111\/imm.13134","volume":"159","author":"YS Yi","year":"2020","unstructured":"Yi YS (2020) Functional crosstalk between non-canonical caspase-11 and canonical NLRP3 inflammasomes during infection-mediated inflammation. Immunology 159:142\u2013155. https:\/\/doi.org\/10.1111\/imm.13134","journal-title":"Immunology"},{"key":"909_CR85","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.105748","volume":"170","author":"R Yuan","year":"2021","unstructured":"Yuan R, Zhao W, Wang QQ, He J, Han S, Gao H et al (2021) Cucurbitacin B inhibits non-small cell lung cancer in vivo and in vitro by triggering TLR4\/NLRP3\/GSDMD-dependent pyroptosis. Pharmacol Res 170:105748. https:\/\/doi.org\/10.1016\/j.phrs.2021.105748","journal-title":"Pharmacol Res"},{"key":"909_CR86","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1038\/s41467-020-14945-2","volume":"11","author":"Z Zas\u0142ona","year":"2020","unstructured":"Zas\u0142ona Z, Flis E, Wilk MM, Carroll RG, Palsson-McDermott EM, Hughes MM et al (2020) Caspase-11 promotes allergic airway inflammation. Nat Commun 11:1055. https:\/\/doi.org\/10.1038\/s41467-020-14945-2","journal-title":"Nat Commun"},{"key":"909_CR87","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1007\/s10495-019-01515-1","volume":"24","author":"CC Zhang","year":"2019","unstructured":"Zhang CC, Li CG, Wang YF, Xu LH, He XH, Zeng QZ et al (2019) Chemotherapeutic paclitaxel and cisplatin differentially induce pyroptosis in A549 lung cancer cells via caspase-3\/GSDME activation. Apoptosis 24:312\u2013325. https:\/\/doi.org\/10.1007\/s10495-019-01515-1","journal-title":"Apoptosis"},{"key":"909_CR88","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.yjmcc.2019.10.008","volume":"138","author":"M Zhang","year":"2020","unstructured":"Zhang M, Xin W, Yu Y, Yang X, Ma C, Zhang H et al (2020) Programmed death-ligand 1 triggers PASMCs pyroptosis and pulmonary vascular fibrosis in pulmonary hypertension. J Mol Cell Cardiol 138:23\u201333. https:\/\/doi.org\/10.1016\/j.yjmcc.2019.10.008","journal-title":"J Mol Cell Cardiol"},{"key":"909_CR89","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119090","volume":"269","author":"MY Zhang","year":"2021","unstructured":"Zhang MY, Jiang YX, Yang YC, Liu JY, Huo C, Ji XL et al (2021) Cigarette smoke extract induces pyroptosis in human bronchial epithelial cells through the ROS\/NLRP3\/caspase-1 pathway. Life Sci 269:119090. https:\/\/doi.org\/10.1016\/j.lfs.2021.119090","journal-title":"Life Sci"},{"key":"909_CR90","doi-asserted-by":"publisher","first-page":"8746895","DOI":"10.1155\/2019\/8746895","volume":"2019","author":"T Zhang","year":"2019","unstructured":"Zhang T, Li Y, Zhu R, Song P, Wei Y, Liang T et al (2019) Transcription factor p53 suppresses tumor growth by prompting pyroptosis in non-small-cell lung cancer. Oxid Med Cell Longev 2019:8746895. https:\/\/doi.org\/10.1155\/2019\/8746895","journal-title":"Oxid Med Cell Longev"},{"key":"909_CR91","doi-asserted-by":"publisher","first-page":"109925","DOI":"10.1016\/j.biopha.2020.109925","volume":"125","author":"J Zhuang","year":"2020","unstructured":"Zhuang J, Cui H, Zhuang L, Zhai Z, Yang F, Luo G et al (2020) Bronchial epithelial pyroptosis promotes airway inflammation in a murine model of toluene diisocyanate-induced asthma. Biomed Pharmacother 125:109925. https:\/\/doi.org\/10.1016\/j.biopha.2020.109925","journal-title":"Biomed Pharmacother"},{"key":"909_CR92","doi-asserted-by":"publisher","first-page":"eaaz7548","DOI":"10.1126\/science.aaz7548","volume":"368","author":"Z Zhou","year":"2020","unstructured":"Zhou Z, He H, Wang K, Shi X, Wang Y, Su Y et al (2020) Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells. Science 368:eaaz7548. https:\/\/doi.org\/10.1126\/science.aaz7548","journal-title":"Science"},{"key":"909_CR93","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.751533","volume":"12","author":"J Zou","year":"2021","unstructured":"Zou J, Zheng Y, Huang Y, Tang D, Kang R, Chen R (2021) The versatile gasdermin family: their function and roles in diseases. Front Immunol 12:751533. https:\/\/doi.org\/10.3389\/fimmu.2021.751533","journal-title":"Front Immunol"},{"key":"909_CR94","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1038\/358167a0","volume":"358","author":"A Zychlinsky","year":"1992","unstructured":"Zychlinsky A, Prevost MC, Sansonetti PJ (1992) Shigella flexneri induces apoptosis in infected macrophages. Nature 358:167\u2013169. https:\/\/doi.org\/10.1038\/358167a0","journal-title":"Nature"}],"container-title":["Journal of Physiology and Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13105-022-00909-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13105-022-00909-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13105-022-00909-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T12:23:02Z","timestamp":1669206182000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13105-022-00909-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,11]]},"references-count":94,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["909"],"URL":"https:\/\/doi.org\/10.1007\/s13105-022-00909-1","relation":{},"ISSN":["1138-7548","1877-8755"],"issn-type":[{"value":"1138-7548","type":"print"},{"value":"1877-8755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,11]]},"assertion":[{"value":"11 February 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 June 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 July 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}}]}}