{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T22:58:33Z","timestamp":1788476313363,"version":"build-2803163510"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T00:00:00Z","timestamp":1704326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T00:00:00Z","timestamp":1704326400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Physiol Biochem"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1007\/s13105-023-01005-8","type":"journal-article","created":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T03:02:31Z","timestamp":1704337351000},"page":"317-328","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Exercise-induced changes in plasma S-Klotho levels are associated with the obtained enhancements of heart rate variability in sedentary middle-aged adults: the FIT-AGEING study"],"prefix":"10.1007","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9995-3455","authenticated-orcid":false,"given":"Gin\u00e9s","family":"Navarro-Lomas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5374-3129","authenticated-orcid":false,"given":"Abel","family":"Plaza-Florido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0614-4545","authenticated-orcid":false,"given":"Alejandro","family":"De-la-O","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1196-9488","authenticated-orcid":false,"given":"Manuel J.","family":"Castillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7207-9016","authenticated-orcid":false,"given":"Francisco J.","family":"Amaro-Gahete","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,4]]},"reference":[{"key":"1005_CR1","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1007\/s11517-006-0119-0","volume":"44","author":"UR Acharya","year":"2006","unstructured":"Acharya UR, Joseph KP, Kannathal N et al (2006) Heart rate variability: a review. Med Biol Eng Comput 44:1031\u20131051","journal-title":"Med Biol Eng Comput"},{"key":"1005_CR2","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/J.PSYNEUEN.2018.12.017","volume":"102","author":"A Agorastos","year":"2019","unstructured":"Agorastos A, Heinig A, Stiedl O et al (2019) Vagal effects of endocrine HPA axis challenges on resting autonomic activity assessed by heart rate variability measures in healthy humans. Psychoneuroendocrinology 102:196\u2013203. https:\/\/doi.org\/10.1016\/J.PSYNEUEN.2018.12.017","journal-title":"Psychoneuroendocrinology"},{"key":"1005_CR3","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.3390\/ijerph15071508","volume":"15","author":"A Alansare","year":"2018","unstructured":"Alansare A, Alford K, Lee S et al (2018) The effects of high-intensity interval training vs. moderate-intensity continuous training on heart rate variability in physically inactive adults. Int J Environ Res Public Health 15:1508. https:\/\/doi.org\/10.3390\/ijerph15071508","journal-title":"Int J Environ Res Public Health"},{"key":"1005_CR4","doi-asserted-by":"publisher","unstructured":"Alc\u00e1ntara J, Plaza-Florido A, Amaro-Gahete F et al (2020) Impact of using different levels of threshold-based artefact correction on the quantification of heart rate variability in three independent human cohorts. J Clin Med 9. https:\/\/doi.org\/10.3390\/JCM9020325","DOI":"10.3390\/JCM9020325"},{"key":"1005_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.archger.2015.11.011","volume":"63","author":"MA Almeida-Santos","year":"2016","unstructured":"Almeida-Santos MA, Barreto-Filho JA, Oliveira JLM et al (2016) Aging, heart rate variability and patterns of autonomic regulation of the heart. Arch Gerontol Geriatr 63:1\u20138. https:\/\/doi.org\/10.1016\/j.archger.2015.11.011","journal-title":"Arch Gerontol Geriatr"},{"key":"1005_CR6","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.conctc.2018.05.013","volume":"11","author":"FJ Amaro-Gahete","year":"2018","unstructured":"Amaro-Gahete FJ, De-la-O A, Jurado-Fasoli L et al (2018) Exercise training as S-Klotho protein stimulator in sedentary healthy adults: rationale, design, and methodology. Contemp Clin Trials Commun 11:10\u201319. https:\/\/doi.org\/10.1016\/j.conctc.2018.05.013","journal-title":"Contemp Clin Trials Commun"},{"key":"1005_CR7","doi-asserted-by":"publisher","first-page":"100","DOI":"10.2174\/1874609811666180702101338","volume":"11","author":"FJ Amaro-Gahete","year":"2018","unstructured":"Amaro-Gahete FJ, de-la-O A, Jurado-Fasoli L et al (2018) Role of exercise on S-Klotho protein regulation: a systematic review. Curr Aging Sci 11:100\u2013107. https:\/\/doi.org\/10.2174\/1874609811666180702101338","journal-title":"Curr Aging Sci"},{"key":"1005_CR8","doi-asserted-by":"publisher","first-page":"2175","DOI":"10.1080\/02640414.2019.1626048","volume":"37","author":"FJ Amaro-Gahete","year":"2019","unstructured":"Amaro-Gahete FJ, De-la-O A, Jurado-Fasoli L et al (2019) Exercise training increases the S-Klotho plasma levels in sedentary middle-aged adults: a randomised controlled trial. The FIT-AGEING study. J Sports Sci 37:2175\u20132183. https:\/\/doi.org\/10.1080\/02640414.2019.1626048","journal-title":"J Sports Sci"},{"key":"1005_CR9","doi-asserted-by":"publisher","first-page":"2698","DOI":"10.18632\/aging.102771","volume":"12","author":"FJ Amaro-Gahete","year":"2020","unstructured":"Amaro-Gahete FJ, Jurado-Fasoli L, Sanchez-Delgado G et al (2020) Relationship between plasma S-Klotho and cardiometabolic risk in sedentary adults. Aging 12:2698\u20132710. https:\/\/doi.org\/10.18632\/aging.102771","journal-title":"Aging"},{"key":"1005_CR10","doi-asserted-by":"publisher","unstructured":"Benichou T, Pereira B, Mermillod M et al (2018) Heart rate variability in type 2 diabetes mellitus: a systematic review and meta\u2013analysis. PLoS One 13. https:\/\/doi.org\/10.1371\/JOURNAL.PONE.0195166","DOI":"10.1371\/JOURNAL.PONE.0195166"},{"key":"1005_CR11","volume-title":"Successful aging: strategies for healthy living","author":"M Bloom","year":"2013","unstructured":"Bloom M, Klein W (2013) Successful aging: strategies for healthy living. Springer Science & Business Media"},{"key":"1005_CR12","doi-asserted-by":"publisher","first-page":"335","DOI":"10.2337\/DC07-0874","volume":"31","author":"MR Carnethon","year":"2008","unstructured":"Carnethon MR, Yan L, Greenland P et al (2008) Resting heart rate in middle age and diabetes development in older age. Diabetes Care 31:335\u2013339. https:\/\/doi.org\/10.2337\/DC07-0874","journal-title":"Diabetes Care"},{"key":"1005_CR13","doi-asserted-by":"publisher","first-page":"213","DOI":"10.2147\/ciia.2006.1.3.213","volume":"1","author":"MJ Castillo-Garz\u00f3n","year":"2006","unstructured":"Castillo-Garz\u00f3n MJ, Ruiz JR, Ortega FB, Guti\u00e9rrez A (2006) Anti-aging therapy through fitness enhancement. Clin Interv Aging 1:213\u2013220","journal-title":"Clin Interv Aging"},{"key":"1005_CR14","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/J.BBI.2014.12.017","volume":"49","author":"TM Cooper","year":"2015","unstructured":"Cooper TM, McKinley PS, Seeman TE et al (2015) Heart rate variability predicts levels of inflammatory markers: evidence for the vagal anti-inflammatory pathway. Brain Behav Immun 49:94\u2013100. https:\/\/doi.org\/10.1016\/J.BBI.2014.12.017","journal-title":"Brain Behav Immun"},{"key":"1005_CR15","doi-asserted-by":"publisher","unstructured":"Ernst G (2017) Heart-rate variability\u2014more than heart beats? Front Public Health 5. https:\/\/doi.org\/10.3389\/fpubh.2017.00240","DOI":"10.3389\/fpubh.2017.00240"},{"key":"1005_CR16","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1007\/s10522-010-9287-2","volume":"11","author":"T Fulop","year":"2010","unstructured":"Fulop T, Larbi A, Witkowski JM et al (2010) Aging, frailty and age-related diseases. Biogerontology 11:547\u2013563","journal-title":"Biogerontology"},{"key":"1005_CR17","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1055\/S-2007-964995\/ID\/21","volume":"29","author":"FX Gamelin","year":"2008","unstructured":"Gamelin FX, Baquet G, Berthoin S, Bosquet L (2008) Validity of the polar S810 to measure R\u2013R intervals in children. Int J Sports Med 29:134\u2013138. https:\/\/doi.org\/10.1055\/S-2007-964995\/ID\/21","journal-title":"Int J Sports Med"},{"issue":"8","key":"1005_CR18","doi-asserted-by":"publisher","first-page":"94","DOI":"10.3390\/JCDD8080094","volume":"8","author":"B Gr\u00e4ssler","year":"2021","unstructured":"Gr\u00e4ssler B, Thielmann B, B\u00f6ckelmann I, H\u00f6kelmann A (2021) Effects of different exercise interventions on cardiac autonomic control and secondary health factors in middle-aged adults: a systematic review. J Cardiovasc Dev Dis 2021 8(8):94. https:\/\/doi.org\/10.3390\/JCDD8080094","journal-title":"J Cardiovasc Dev Dis 2021"},{"key":"1005_CR19","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1093\/EUROPACE\/EUS341","volume":"15","author":"S Hillebrand","year":"2013","unstructured":"Hillebrand S, Gast KB, de Mutsert R et al (2013) Heart rate variability and first cardiovascular event in populations without known cardiovascular disease: meta-analysis and dose-response meta-regression. Europace 15:742\u2013749. https:\/\/doi.org\/10.1093\/EUROPACE\/EUS341","journal-title":"Europace"},{"key":"1005_CR20","first-page":"1","volume":"6","author":"K Jin","year":"2015","unstructured":"Jin K, Simpkins JW, Ji X et al (2015) The critical need to promote research of aging and aging-related diseases to improve health and longevity of the elderly population. Aging Dis 6:1\u20135","journal-title":"Aging Dis"},{"key":"1005_CR21","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1111\/PRD.12126","volume":"72","author":"E Kanasi","year":"2016","unstructured":"Kanasi E, Ayilavarapu S, Jones J (2016) The aging population: demographics and the biology of aging. Periodontol 2000 72:13\u201318. https:\/\/doi.org\/10.1111\/PRD.12126","journal-title":"Periodontol 2000"},{"key":"1005_CR22","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1016\/j.bbrc.2015.10.018","volume":"467","author":"D Koyama","year":"2015","unstructured":"Koyama D, Sato Y, Aizawa M et al (2015) Soluble \u03b1klotho as a candidate for the biomarker of aging. Biochem Biophys Res Commun 467:1019\u20131025. https:\/\/doi.org\/10.1016\/j.bbrc.2015.10.018","journal-title":"Biochem Biophys Res Commun"},{"key":"1005_CR23","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/s41581-018-0078-3","volume":"15","author":"M Kuro-o","year":"2019","unstructured":"Kuro-o M (2019) The Klotho proteins in health and disease. Nat Rev Nephrol 15:27\u201344","journal-title":"Nat Rev Nephrol"},{"key":"1005_CR24","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/36285","volume":"390","author":"M Kuro-o","year":"1997","unstructured":"Kuro-o M, Matsumura Y, Aizawa H et al (1997) Mutation of the mouse Klotho gene leads to a syndrome resembling ageing. Nature 390:45\u201351. https:\/\/doi.org\/10.1038\/36285","journal-title":"Nature"},{"key":"1005_CR25","doi-asserted-by":"publisher","first-page":"209","DOI":"10.5483\/BMBREP.2015.48.4.275","volume":"48","author":"DY Lee","year":"2015","unstructured":"Lee DY, Kim E, Choi MH (2015) Technical and clinical aspects of cortisol as a biochemical marker of chronic stress. BMB Rep 48:209\u2013216. https:\/\/doi.org\/10.5483\/BMBREP.2015.48.4.275","journal-title":"BMB Rep"},{"key":"1005_CR26","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.2337\/DC19-1384","volume":"43","author":"DY Lee","year":"2020","unstructured":"Lee DY, Lee MY, Cho JH et al (2020) Decreased vagal activity and deviation in sympathetic activity precedes development of diabetes. Diabetes Care 43:1336\u20131343. https:\/\/doi.org\/10.2337\/DC19-1384","journal-title":"Diabetes Care"},{"key":"1005_CR27","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","volume":"153","author":"C L\u00f3pez-Ot\u00edn","year":"2013","unstructured":"L\u00f3pez-Ot\u00edn C, Blasco MA, Partridge L et al (2013) The hallmarks of aging. Cell 153:1194","journal-title":"Cell"},{"key":"1005_CR28","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1097\/PSY.0B013E3181576118","volume":"69","author":"AL Marsland","year":"2007","unstructured":"Marsland AL, Gianaros PJ, Prather AA et al (2007) Stimulated production of proinflammatory cytokines covaries inversely with heart rate variability. Psychosom Med 69:709\u2013716. https:\/\/doi.org\/10.1097\/PSY.0B013E3181576118","journal-title":"Psychosom Med"},{"key":"1005_CR29","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1123\/ijspp.2014-0235","volume":"10","author":"J Naranjo-Orellana","year":"2015","unstructured":"Naranjo-Orellana J, de La Cruz TB, Cachadi\u00f1a ES et al (2015) Two new indexes for the assessment of autonomic balance in elite soccer players. Int J Sports Physiol Perform 10:452\u2013457. https:\/\/doi.org\/10.1123\/ijspp.2014-0235","journal-title":"Int J Sports Physiol Perform"},{"key":"1005_CR30","doi-asserted-by":"publisher","unstructured":"Navarro-Lomas G, De-La-O A, Jurado-Fasoli L et al (2020) Assessment of autonomous nerve system through non-linear heart rate variability outcomes in sedentary healthy adults. PeerJ 8. https:\/\/doi.org\/10.7717\/peerj.10178","DOI":"10.7717\/peerj.10178"},{"key":"1005_CR31","doi-asserted-by":"crossref","unstructured":"Navarro-Lomas G, Dote-Montero M, Alcantara JM, et al (2022) Different exercise training modalities similarly improve heart rate variability in sedentary middle-aged adults: the FIT-AGEING randomized controlled trial. Eur J Appl Physiol\u00a0122(8):1863\u20131874","DOI":"10.1007\/s00421-022-04957-9"},{"key":"1005_CR32","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.1016\/j.amjcard.2013.07.042","volume":"112","author":"A Pittaras","year":"2013","unstructured":"Pittaras A, Kheirbek RE (2013) Heart rate at rest, exercise capacity, and mortality risk in veterans Obesity View project Exercise-Lipids View project. Am J Cardiol 112:1605\u20131609. https:\/\/doi.org\/10.1016\/j.amjcard.2013.07.042","journal-title":"Am J Cardiol"},{"key":"1005_CR33","doi-asserted-by":"publisher","unstructured":"Plaza-Florido A, Alcantara JMA, Migueles JH et al (2020) Inter- and intra-researcher reproducibility of heart rate variability parameters in three human cohorts. Sci Rep 10. https:\/\/doi.org\/10.1038\/S41598-020-68197-7","DOI":"10.1038\/S41598-020-68197-7"},{"key":"1005_CR34","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.1007\/S00392-019-01486-Y","volume":"108","author":"A Plaza-Florido","year":"2019","unstructured":"Plaza-Florido A, Migueles JH, Sacha J, Ortega FB (2019) The role of heart rate in the assessment of cardiac autonomic modulation with heart rate variability. Clin Res Cardiol 108:1408\u20131409. https:\/\/doi.org\/10.1007\/S00392-019-01486-Y","journal-title":"Clin Res Cardiol"},{"key":"1005_CR35","doi-asserted-by":"publisher","first-page":"745","DOI":"10.33963\/KP.A2021.0054","volume":"79","author":"A Plaza-Florido","year":"2021","unstructured":"Plaza-Florido A, Sacha J, Alcantara JM (2021) Short-term heart rate variability in resting conditions: methodological considerations. Kardiologia Polska (Polish Heart Journal) 79:745\u2013755. https:\/\/doi.org\/10.33963\/KP.A2021.0054","journal-title":"Kardiologia Polska (Polish Heart Journal)"},{"key":"1005_CR36","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/J.PSYNEUEN.2018.05.004","volume":"94","author":"MM Pulopulos","year":"2018","unstructured":"Pulopulos MM, Vanderhasselt MA, de Raedt R (2018) Association between changes in heart rate variability during the anticipation of a stressful situation and the stress-induced cortisol response. Psychoneuroendocrinology 94:63. https:\/\/doi.org\/10.1016\/J.PSYNEUEN.2018.05.004","journal-title":"Psychoneuroendocrinology"},{"key":"1005_CR37","unstructured":"Ruengvirayudh P, Brooks GP (2016) Comparing stepwise regression models to the best-subsets models, or, the art of stepwise. Gen Linear Model J"},{"key":"1005_CR38","doi-asserted-by":"publisher","unstructured":"Sacha J (2013) Why should one normalize heart rate variability with respect to average heart rate. Front Physiol 4. https:\/\/doi.org\/10.3389\/FPHYS.2013.00306","DOI":"10.3389\/FPHYS.2013.00306"},{"key":"1005_CR39","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1016\/j.cell.2016.07.050","volume":"166","author":"P Sen","year":"2016","unstructured":"Sen P, Shah PP, Nativio R, Berger SL (2016) Epigenetic mechanisms of longevity and aging. Cell 166:822\u2013839","journal-title":"Cell"},{"key":"1005_CR40","doi-asserted-by":"publisher","first-page":"258","DOI":"10.3389\/fpubh.2017.00258","volume":"5","author":"F Shaffer","year":"2017","unstructured":"Shaffer F, Ginsberg JP (2017) An overview of heart rate variability metrics and norms. Front Public Health 5:258. https:\/\/doi.org\/10.3389\/fpubh.2017.00258","journal-title":"Front Public Health"},{"key":"1005_CR41","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/J.IJCARD.2018.08.005","volume":"275","author":"JPH Tan","year":"2019","unstructured":"Tan JPH, Beilharz JE, Vollmer-Conna U, Cvejic E (2019) Heart rate variability as a marker of healthy ageing. Int J Cardiol 275:101\u2013103. https:\/\/doi.org\/10.1016\/J.IJCARD.2018.08.005","journal-title":"Int J Cardiol"},{"key":"1005_CR42","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.cmpb.2013.07.024","volume":"113","author":"MP Tarvainen","year":"2014","unstructured":"Tarvainen MP, Niskanen JP, Lipponen JA et al (2014) Kubios HRV - heart rate variability analysis software. Comput Methods Programs Biomed 113:210\u2013220. https:\/\/doi.org\/10.1016\/j.cmpb.2013.07.024","journal-title":"Comput Methods Programs Biomed"},{"key":"1005_CR43","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1161\/01.CIR.93.5.1043","volume":"93","author":"Task force of the European Society of Cardiology and the North American Society for Pacing and Electrophysiology","year":"1996","unstructured":"Task force of the European Society of Cardiology and the North American Society for Pacing and Electrophysiology (1996) Heart rate variability: standards of measurement, physiological interpretation and clinical use. Circulation 93:1043\u20131065","journal-title":"Circulation"},{"key":"1005_CR44","first-page":"708","volume":"9","author":"MB Tayel","year":"2015","unstructured":"Tayel MB, AlSaba EI (2015) Poincar\u00e9 plot for heart rate variability. J Biomed Biol Eng 9:708\u2013711","journal-title":"J Biomed Biol Eng"},{"key":"1005_CR45","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1196\/ANNALS.1366.014","volume":"1088","author":"JF Thayer","year":"2006","unstructured":"Thayer JF, Sternberg E (2006) Beyond heart rate variability. Ann N Y Acad Sci 1088:361\u2013372. https:\/\/doi.org\/10.1196\/ANNALS.1366.014","journal-title":"Ann N Y Acad Sci"},{"key":"1005_CR46","doi-asserted-by":"publisher","first-page":"2850","DOI":"10.1161\/01.CIR.94.11.2850","volume":"94","author":"H Tsuji","year":"1996","unstructured":"Tsuji H, Larson MG, Venditti FJ et al (1996) Impact of reduced heart rate variability on risk for cardiac events: the Framingham Heart Study. Circulation 94:2850\u20132855. https:\/\/doi.org\/10.1161\/01.CIR.94.11.2850","journal-title":"Circulation"},{"key":"1005_CR47","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.pcad.2009.05.004","volume":"52","author":"M Valentini","year":"2009","unstructured":"Valentini M, Parati G (2009) Variables influencing heart rate. Prog Cardiovasc Dis 52:11\u201319. https:\/\/doi.org\/10.1016\/j.pcad.2009.05.004","journal-title":"Prog Cardiovasc Dis"},{"key":"1005_CR48","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1097\/MBP.0000000000000143","volume":"20","author":"FVA Vasconcellos","year":"2015","unstructured":"Vasconcellos FVA, Seabra A, Cunha FA et al (2015) Heart rate variability assessment with fingertip photoplethysmography and polar RS800cx as compared with electrocardiography in obese adolescents. Blood Press Monit 20:351\u2013360. https:\/\/doi.org\/10.1097\/MBP.0000000000000143","journal-title":"Blood Press Monit"},{"key":"1005_CR49","doi-asserted-by":"publisher","first-page":"111518","DOI":"10.1016\/J.EXGER.2021.111518","volume":"154","author":"F Veronesi","year":"2021","unstructured":"Veronesi F, Borsari V, Cherubini A, Fini M (2021) Association of Klotho with physical performance and frailty in middle-aged and older adults: a systematic review. Exp Gerontol 154:111518. https:\/\/doi.org\/10.1016\/J.EXGER.2021.111518","journal-title":"Exp Gerontol"},{"key":"1005_CR50","doi-asserted-by":"crossref","unstructured":"Williams DP, Jarczok MN, Ellis RJ et al (2017) Two-week test-retest reliability of the Polar\u00ae RS800CX TM to record heart rate variability.\u00a0Clin Physiol Funct Imaging 37(6):776\u2013781","DOI":"10.1111\/cpf.12321"},{"key":"1005_CR51","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1519\/JSC.0000000000003084","volume":"35","author":"A Wong","year":"2021","unstructured":"Wong A, Figueroa A (2021) Effects of acute stretching exercise and training on heart rate variability: a review. J Strength Cond Res 35:1459\u20131466","journal-title":"J Strength Cond Res"},{"key":"1005_CR52","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1210\/er.2013-1079","volume":"36","author":"Y Xu","year":"2015","unstructured":"Xu Y, Sun Z (2015) Molecular basis of Klotho: from gene to function in aging. Endocr Rev 36:174\u2013193","journal-title":"Endocr Rev"},{"key":"1005_CR53","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1016\/j.amjcard.2009.12.022","volume":"105","author":"U Zulfiqar","year":"2010","unstructured":"Zulfiqar U, Jurivich DA, Gao W, Singer DH (2010) Relation of high heart rate variability to healthy longevity. Am J Cardiol 105:1181\u20131185. https:\/\/doi.org\/10.1016\/j.amjcard.2009.12.022","journal-title":"Am J Cardiol"}],"container-title":["Journal of Physiology and Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13105-023-01005-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13105-023-01005-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13105-023-01005-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T06:03:31Z","timestamp":1714975411000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13105-023-01005-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,4]]},"references-count":53,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["1005"],"URL":"https:\/\/doi.org\/10.1007\/s13105-023-01005-8","relation":{},"ISSN":["1138-7548","1877-8755"],"issn-type":[{"value":"1138-7548","type":"print"},{"value":"1877-8755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,4]]},"assertion":[{"value":"20 June 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 December 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 January 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}