{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:55:07Z","timestamp":1791233707138,"version":"4.1.0"},"reference-count":118,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T00:00:00Z","timestamp":1739923200000},"content-version":"vor","delay-in-days":18,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100003093","name":"Ministry of Higher Education, Malaysia","doi-asserted-by":"publisher","award":["FRGS\/1\/2019\/SKK08\/UKM\/01\/4"],"award-info":[{"award-number":["FRGS\/1\/2019\/SKK08\/UKM\/01\/4"]}],"id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Physiol Biochem"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Sarcopenia, a widespread condition, is characterized by a variety of factors influencing its development. The causes of sarcopenia differ depending on the age of the individual. It is defined as the combination of decreased muscle mass and impaired muscle function, primarily observed in association with ageing. As people age from 20 to 80 years old, there is an approximate 30% reduction in muscle mass and a 20% decline in cross-sectional area. This decline is attributed to a decrease in the size and number of muscle fibres. The regression of muscle mass and strength increases the risk of fractures, frailty, reduced quality of life, and loss of independence. Muscle cells, fibres, and tissues shrink, resulting in diminished muscle power, volume, and strength in major muscle groups. One prominent theory of cellular ageing posits a strong positive relationship between age and oxidative damage. Heightened oxidative stress leads to early-onset sarcopenia, characterized by neuromuscular innervation breakdown, muscle atrophy, and dysfunctional mitochondrial muscles. Ageing muscles generate more reactive oxygen species (ROS), and experience decreased oxygen consumption and ATP synthesis compared to younger muscles. Additionally, changes in mitochondrial protein interactions, cristae structure, and networks may contribute to ADP insensitivity, which ultimately leads to sarcopenia. Within this framework, this review provides a comprehensive summary of our current understanding of the role of mitochondria in sarcopenia and other muscle degenerative diseases, highlighting the crucial need for further research in these areas.\u00a0<\/jats:p>","DOI":"10.1007\/s13105-024-01062-7","type":"journal-article","created":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T07:38:42Z","timestamp":1739950722000},"page":"1-20","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["The link between Mitochondria and Sarcopenia"],"prefix":"10.1007","volume":"81","author":[{"given":"Nurul Tihani","family":"Kamarulzaman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzana","family":"Makpol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,19]]},"reference":[{"key":"1062_CR1","doi-asserted-by":"crossref","unstructured":"Abdul Rashid S, Ghani P, Daud N, Hilmi AG, Azemi Z, Wahid SS, S. N., Razak M (2016) Malaysia\u2019s Ageing Population Trends. Dlm. (pnyt.). hlm. 981\u2013990","DOI":"10.1007\/978-981-10-1458-1_88"},{"key":"1062_CR2","unstructured":"Ahmad M, Wolberg A, Kahwaji CI (2024) Biochemistry, Electron Transport Chain. Dlm. (pnyt.). Statpearls, hlm. Treasure Island (FL) ineligible companies. Disclosure: Adam Wolberg declares no relevant financial relationships with ineligible companies. Disclosure: Chadi Kahwaji declares no relevant financial relationships with ineligible companies.: StatPearls Publishing"},{"issue":"3","key":"1062_CR3","doi-asserted-by":"publisher","first-page":"e13569","DOI":"10.1111\/acel.13569","volume":"21","author":"B Ahn","year":"2022","unstructured":"Ahn B, Ranjit R, Kneis P, Xu H, Piekarz KM, Freeman WM, Kinter M, Richardson A, Ran Q, Brooks SV, Van Remmen H (2022) Scavenging mitochondrial hydrogen peroxide by Peroxiredoxin 3 overexpression attenuates contractile dysfunction and muscle atrophy in a murine model of Accelerated Sarcopenia. Aging Cell 21(3):e13569","journal-title":"Aging Cell"},{"key":"1062_CR4","doi-asserted-by":"publisher","first-page":"100940","DOI":"10.1016\/j.arr.2019.100940","volume":"54","author":"M Akbari","year":"2019","unstructured":"Akbari M, Kirkwood TBL, Bohr VA (2019) Mitochondria in the Signaling pathways that control longevity and Health Span. Ageing Res Rev 54:100940","journal-title":"Ageing Res Rev"},{"key":"1062_CR5","volume-title":"Ageing Process and Physiological Changes. Dlm. (pnyt.). hlm","author":"S Amarya","year":"2018","unstructured":"Amarya S, Singh K, Sabharwal M (2018) Ageing process and physiological changes. Dlm. (pnyt.). Hlm. InTech"},{"issue":"1","key":"1062_CR6","doi-asserted-by":"publisher","first-page":"197","DOI":"10.3390\/cells9010197","volume":"9","author":"M-E Anagnostou","year":"2020","unstructured":"Anagnostou M-E, Hepple RT (2020) Mitochondrial mechanisms of Neuromuscular Junction Degeneration with Aging. Cells 9(1):197","journal-title":"Cells"},{"issue":"1","key":"1062_CR7","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1172\/JCI120848","volume":"129","author":"E Area-Gomez","year":"2019","unstructured":"Area-Gomez E, Guardia-Laguarta C, Schon EA, Przedborski S (2019) Mitochondria, Oxphos, and neurodegeneration: cells are not just running out of gas. J Clin Invest 129(1):34\u201345","journal-title":"J Clin Invest"},{"issue":"1","key":"1062_CR8","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1111\/acel.12405","volume":"15","author":"SI Arriola Apelo","year":"2016","unstructured":"Arriola Apelo SI, Neuman JC, Baar EL, Syed FA, Cummings NE, Brar HK, Pumper CP, Kimple ME, Lamming DW (2016) Alternative Rapamycin Treatment regimens mitigate the impact of rapamycin on glucose homeostasis and the Immune System. Aging Cell 15(1):28\u201338","journal-title":"Aging Cell"},{"issue":"7","key":"1062_CR9","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1038\/cr.2011.56","volume":"21","author":"L Bai","year":"2011","unstructured":"Bai L, Deng X, Li J, Wang M, Li Q, An W, A, D., Cong Y-S (2011) Regulation of Cellular Senescence by the essential Caveolar Component Ptrf\/Cavin-1. Cell Res 21(7):1088\u20131101","journal-title":"Cell Res"},{"issue":"5","key":"1062_CR10","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1016\/j.molcel.2019.03.031","volume":"74","author":"E Balsa","year":"2019","unstructured":"Balsa E, Soustek MS, Thomas A, Cogliati S, Garcia-Poyatos C, Martin-Garcia E, Jedrychowski M, Gygi SP, Enriquez JA, Puigserver P (2019) Er and Nutrient Stress Promote Assembly of Respiratory Chain supercomplexes through the Perk-Eif2alpha Axis. Mol Cell 74(5):877\u2013890 e876","journal-title":"Mol Cell"},{"issue":"12","key":"1062_CR11","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.1089\/ars.2012.5148","volume":"19","author":"G Barja","year":"2013","unstructured":"Barja G (2013) Updating the mitochondrial free radical theory of aging: an Integrated View, Key Aspects, and confounding concepts. Antioxid Redox Signal 19(12):1420\u20131445","journal-title":"Antioxid Redox Signal"},{"issue":"5","key":"1062_CR12","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1038\/cdd.2010.142","volume":"18","author":"L Bouman","year":"2011","unstructured":"Bouman L, Schlierf A, Lutz AK, Shan J, Deinlein A, Kast J, Galehdar Z, Palmisano V, Patenge N, Berg D, Gasser T, Augustin R, Tr\u00fcmbach D, Irrcher I, Park DS, Wurst W, Kilberg MS, Tatzelt J, Winklhofer KF (2011) Parkin is transcriptionally regulated by Atf4: evidence for an interconnection between mitochondrial stress and er stress. Cell Death Differ 18(5):769\u2013782","journal-title":"Cell Death Differ"},{"key":"1062_CR13","doi-asserted-by":"publisher","first-page":"99","DOI":"10.3389\/fphys.2014.00099","volume":"5","author":"NE Brooks","year":"2014","unstructured":"Brooks NE, Myburgh KH (2014) Skeletal muscle wasting with Disuse Atrophy is multi-dimensional: the Response and Interaction of Myonuclei, Satellite cells and signaling pathways. Front Physiol 5:99","journal-title":"Front Physiol"},{"issue":"1","key":"1062_CR14","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.cmet.2014.03.002","volume":"20","author":"K Burkewitz","year":"2014","unstructured":"Burkewitz K, Zhang Y, William (2014) Ampk at the Nexus of Energetics and Aging. Cell Metabol 20(1):10\u201325","journal-title":"Cell Metabol"},{"key":"1062_CR15","doi-asserted-by":"crossref","unstructured":"Calvani R, Joseph A-M, Adhihetty PJ, Miccheli A, Bossola M, Leeuwenburgh C, Bernabei R, Marzetti E (2013) Mitochondrial Pathways in Sarcopenia of Aging and Disuse Muscle Atrophy. bchm 394(3): 393\u2013414","DOI":"10.1515\/hsz-2012-0247"},{"issue":"2","key":"1062_CR16","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1097\/MOL.0b013e328328d0a4","volume":"20","author":"C Cant\u00f3","year":"2009","unstructured":"Cant\u00f3 C, Auwerx J (2009) Pgc-1alpha, Sirt1 and ampk, an Energy Sensing Network that Controls Energy expenditure. Curr Opin Lipidol 20(2):98\u2013105","journal-title":"Curr Opin Lipidol"},{"issue":"1","key":"1062_CR17","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.cmet.2015.05.023","volume":"22","author":"C Cant\u00f3","year":"2015","unstructured":"Cant\u00f3 C, Keir, Auwerx J (2015) Nad\u2009+\u2009metabolism and the Control of Energy Homeostasis: a Balancing Act between Mitochondria and the Nucleus. Cell Metabol 22(1):31\u201353","journal-title":"Cell Metabol"},{"issue":"3","key":"1062_CR18","first-page":"208","volume":"30","author":"HN Carter","year":"2015","unstructured":"Carter HN, Chen CC, Hood DA (2015) Mitochondria, Muscle Health, and Exercise with advancing age. Physiol (Bethesda) 30(3):208\u2013223","journal-title":"Physiol (Bethesda)"},{"issue":"3","key":"1062_CR19","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1007\/s10549-017-4640-7","volume":"168","author":"J-W Chae","year":"2018","unstructured":"Chae J-W, Chua PS, Ng T, Yeo AHL, Shwe M, Gan YX, Dorajoo S, Foo KM, Loh KW-J, Koo S-L, Chay WY, Tan TJY, Beh SY, Lim EH, Lee GE, Dent R, Yap YS, Ng R, Ho HK, Chan A (2018) Association of mitochondrial DNA content in Peripheral blood with Cancer-related fatigue and chemotherapy-related cognitive impairment in early-stage breast Cancer patients: a prospective cohort study. Breast Cancer Res Treat 168(3):713\u2013721","journal-title":"Breast Cancer Res Treat"},{"issue":"1","key":"1062_CR20","doi-asserted-by":"publisher","first-page":"e0220857","DOI":"10.1371\/journal.pone.0220857","volume":"15","author":"ES Chang","year":"2020","unstructured":"Chang ES, Kannoth S, Levy S, Wang S-Y, Lee JE, Levy BR (2020) Global Reach of Ageism on older persons\u2019 health: a systematic review. PLoS ONE 15(1):e0220857","journal-title":"PLoS ONE"},{"issue":"13","key":"1062_CR21","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.1002\/1873-3468.13498","volume":"593","author":"J Chapman","year":"2019","unstructured":"Chapman J, Fielder E, Passos JF (2019) Mitochondrial dysfunction and cell senescence: deciphering a Complex Relationship. FEBS Lett 593(13):1566\u20131579","journal-title":"FEBS Lett"},{"issue":"12","key":"1062_CR22","doi-asserted-by":"publisher","first-page":"1638","DOI":"10.1093\/gerona\/glw059","volume":"71","author":"S Choi","year":"2016","unstructured":"Choi S, Reiter DA, Shardell M, Simonsick EM, Studenski S, Spencer RG, Fishbein KW, Ferrucci L (2016) <sup\u2009>\u200931\u2009P Magnetic Resonance Spectroscopy Assessment of Muscle Bioenergetics as a predictor of Gait Speed in the Baltimore Longitudinal Study of Aging<\/sup\u2009>. Journals Gerontol Ser A: Biol Sci Med Sci 71(12):1638\u20131645","journal-title":"Journals Gerontol Ser A: Biol Sci Med Sci"},{"issue":"11","key":"1062_CR23","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1038\/nrn4020","volume":"16","author":"H-M Chow","year":"2015","unstructured":"Chow H-M, Herrup K (2015) Genomic Integrity and the Ageing Brain. Nat Rev Neurosci 16(11):672\u2013684","journal-title":"Nat Rev Neurosci"},{"key":"1062_CR24","doi-asserted-by":"crossref","unstructured":"Coen PM, Jubrias SA, Distefano G, Amati F, Mackey DC, Glynn NW, Manini TM, Wohlgemuth SE, Leeuwenburgh C, Cummings SR, Newman AB, Ferrucci L, Toledo FG, Shankland E, Conley KE, Goodpaster BH 2013. Skeletal Muscle Mitochondrial Energetics Are Associated with Maximal Aerobic Capacity and Walking Speed in Older Adults. J Gerontol Biol Sci Med Sci 68(4):447\u2013455","DOI":"10.1093\/gerona\/gls196"},{"key":"1062_CR25","unstructured":"Copyright (2024) \u00a9 StatPearls Publishing LLC"},{"issue":"7","key":"1062_CR26","doi-asserted-by":"publisher","first-page":"724","DOI":"10.15252\/embj.201592862","volume":"35","author":"C Correia-Melo","year":"2016","unstructured":"Correia-Melo C, Marques FD, Anderson R, Hewitt G, Hewitt R, Cole J, Carroll BM, Miwa S, Birch J, Merz A, Rushton MD, Charles M, Jurk D, Tait SW, Czapiewski R, Greaves L, Nelson G, Bohlooly\u2010Y M, Rodriguez\u2010Cuenca S, Vidal\u2010Puig A, Mann D, Saretzki G, Quarato G, Green DR, Adams PD, Zglinicki T, Korolchuk VI, Passos JF (2016) Mitochondria are required for pro\u2010ageing features of the senescent phenotype. EMBO J 35(7):724\u2013742","journal-title":"EMBO J"},{"issue":"10191","key":"1062_CR27","doi-asserted-by":"publisher","first-page":"2636","DOI":"10.1016\/S0140-6736(19)31138-9","volume":"393","author":"AJ Cruz-Jentoft","year":"2019","unstructured":"Cruz-Jentoft AJ, Sayer AA (2019) Sarcopenia Lancet 393(10191):2636\u20132646","journal-title":"Sarcopenia Lancet"},{"issue":"1","key":"1062_CR28","doi-asserted-by":"publisher","first-page":"34","DOI":"10.18632\/aging.101358","volume":"10","author":"A Del Campo","year":"2018","unstructured":"Del Campo A, Contreras-Hernandez I, Castro-Sepulveda M, Campos CA, Figueroa R, Tevy MF, Eisner V, Casas M, Jaimovich E (2018) Muscle function decline and Mitochondria changes in Middle Age Precede Sarcopenia in mice. Aging 10(1):34\u201355","journal-title":"Aging"},{"issue":"12","key":"1062_CR29","doi-asserted-by":"publisher","first-page":"809","DOI":"10.2165\/00007256-200434120-00002","volume":"34","author":"MR Deschenes","year":"2004","unstructured":"Deschenes MR (2004) Effects of Aging on muscle fibre type and size. Sports Med 34(12):809\u2013824","journal-title":"Sports Med"},{"key":"1062_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2020\/9829176","volume":"2020","author":"S Di Meo","year":"2020","unstructured":"Di Meo S, Venditti P (2020) Evolution of the knowledge of free radicals and other oxidants. Oxidative Med Cell Longev 2020:1\u201332","journal-title":"Oxidative Med Cell Longev"},{"issue":"3","key":"1062_CR31","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1002\/iub.608","volume":"64","author":"LM Dillon","year":"2012","unstructured":"Dillon LM, Rebelo AP, Moraes CT (2012) The role of Pgc-1 coactivators in aging skeletal muscle and heart. IUBMB Life 64(3):231\u2013241","journal-title":"IUBMB Life"},{"issue":"4","key":"1062_CR32","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1002\/jcsm.12082","volume":"6","author":"C Drescher","year":"2015","unstructured":"Drescher C, Konishi M, Ebner N, Springer J (2015) Loss of muscle Mass: current developments in Cachexia and Sarcopenia focused on biomarkers and treatment. J Cachexia Sarcopenia Muscle 6(4):303\u2013311","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"6016","key":"1062_CR33","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1126\/science.1196371","volume":"331","author":"DF Egan","year":"2011","unstructured":"Egan DF, Shackelford DB, Mihaylova MM, Gelino S, Kohnz RA, Mair W, Vasquez DS, Joshi A, Gwinn DM, Taylor R, Asara JM, Fitzpatrick J, Dillin A, Viollet B, Kundu M, Hansen M, Shaw RJ (2011) Phosphorylation of Ulk1 (Hatg1) by Amp-Activated Protein Kinase Connects Energy Sensing to Mitophagy. Science 331(6016):456\u2013461","journal-title":"Science"},{"issue":"6","key":"1062_CR34","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1111\/febs.14663","volume":"286","author":"NB Fakouri","year":"2019","unstructured":"Fakouri NB, Hou Y, Demarest TG, Christiansen LS, Okur MN, Mohanty JG, Croteau DL, Bohr VA (2019) Toward understanding genomic instability, mitochondrial dysfunction and aging. FEBS J 286(6):1058\u20131073","journal-title":"FEBS J"},{"issue":"10","key":"1062_CR35","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1016\/j.molmed.2017.08.001","volume":"23","author":"EF Fang","year":"2017","unstructured":"Fang EF, Lautrup S, Hou Y, Demarest TG, Croteau DL, Mattson MP, Bohr VA (2017) Nad(+) in aging: Molecular mechanisms and translational implications. Trends Mol Med 23(10):899\u2013916","journal-title":"Trends Mol Med"},{"issue":"3","key":"1062_CR36","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1038\/s41593-018-0332-9","volume":"22","author":"EF Fang","year":"2019","unstructured":"Fang EF, Hou Y, Palikaras K, Adriaanse BA, Kerr JS, Yang B, Lautrup S, Hasan-Olive MM, Caponio D, Dan X, Rockt\u00e4schel P, Croteau DL, Akbari M, Greig NH, Fladby T, Nilsen H, Cader MZ, Mattson MP, Tavernarakis N, Bohr VA (2019) Mitophagy inhibits Amyloid-\u0392 and Tau Pathology and reverses cognitive deficits in models of Alzheimer\u2019s Disease. Nat Neurosci 22(3):401\u2013412","journal-title":"Nat Neurosci"},{"issue":"3","key":"1062_CR37","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/s13539-013-0105-y","volume":"4","author":"J Farkas","year":"2013","unstructured":"Farkas J, Von Haehling S, Kalantar-Zadeh K, Morley JE, Anker SD, Lainscak M (2013) Cachexia as a Major Public Health Problem: frequent, costly, and deadly. J Cachexia Sarcopenia Muscle 4(3):173\u2013178","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"2","key":"1062_CR38","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1021\/acs.jproteome.5b00840","volume":"15","author":"P Fazelzadeh","year":"2016","unstructured":"Fazelzadeh P, Hangelbroek RWJ, Tieland M, De Groot LCPGM, Verdijk LB, Van Loon LJC, Smilde AK, Alves RDaM, Vervoort J, M\u00fcller M, Van Duynhoven JPM, Boekschoten MV (2016) The muscle Metabolome differs between healthy and frail older adults. J Proteome Res 15(2):499\u2013509","journal-title":"J Proteome Res"},{"issue":"3","key":"1062_CR39","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.tem.2016.09.005","volume":"28","author":"C Franceschi","year":"2017","unstructured":"Franceschi C, Garagnani P, Vitale G, Capri M, Salvioli S (2017) Inflammaging and \u2018Garb-Aging\u2019. Trends Endocrinol Metab 28(3):199\u2013212","journal-title":"Trends Endocrinol Metab"},{"issue":"13","key":"1062_CR40","doi-asserted-by":"publisher","first-page":"1811","DOI":"10.15252\/embj.201796697","volume":"36","author":"L Galluzzi","year":"2017","unstructured":"Galluzzi L, Baehrecke EH, Ballabio A, Boya P, Bravo-San Pedro JM, Cecconi F, Choi AM, Chu CT, Codogno P, Colombo MI, Cuervo AM, Debnath J, Deretic V, Dikic I, Eskelinen EL, Fimia GM, Fulda S, Gewirtz DA, Green DR, Hansen M, Harper JW, J\u00e4\u00e4ttel\u00e4 M, Johansen T, Juhasz G, Kimmelman AC, Kraft C, Ktistakis NT, Kumar S, Levine B, Lopez\u2010Otin C, Madeo F, Martens S, Martinez J, Melendez A, Mizushima N, M\u00fcnz C, Murphy LO, Penninger JM, Piacentini M, Reggiori F, Rubinsztein DC, Ryan KM, Santambrogio L, Scorrano L, Simon AK, Simon HU, Simonsen A, Tavernarakis N, Tooze SA, Yoshimori T, Yuan J, Yue Z, Zhong Q, Kroemer G (2017) Molecular definitions of Autophagy and related processes. EMBO J 36(13):1811\u20131836","journal-title":"EMBO J"},{"issue":"3","key":"1062_CR41","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1016\/j.cell.2015.10.001","volume":"163","author":"Gerald & Tamas","year":"2015","unstructured":"Gerald & Tamas (2015) Mitochondrial Ros Signaling in Organismal Homeostasis. Cell 163(3):560\u2013569","journal-title":"Cell"},{"issue":"1","key":"1062_CR42","doi-asserted-by":"publisher","first-page":"32985","DOI":"10.1038\/srep32985","volume":"6","author":"RJ Giedt","year":"2016","unstructured":"Giedt RJ, Feruglio F, Pathania P, Yang D, Kilcoyne KS, Vinegoni A, Mitchison C, T. J., Weissleder R (2016) Computational imaging reveals mitochondrial morphology as a biomarker of Cancer phenotype and drug response. Sci Rep 6(1):32985","journal-title":"Sci Rep"},{"key":"1062_CR43","doi-asserted-by":"publisher","first-page":"111324","DOI":"10.1016\/j.mad.2020.111324","volume":"190","author":"A Gioran","year":"2020","unstructured":"Gioran A, Chondrogianni N (2020) Mitochondria (Cross)talk with Proteostatic mechanisms: focusing on Ageing and neurodegenerative diseases. Mech Ageing Dev 190:111324","journal-title":"Mech Ageing Dev"},{"issue":"2","key":"1062_CR44","doi-asserted-by":"publisher","first-page":"e12725","DOI":"10.1111\/acel.12725","volume":"17","author":"M Gonzalez-Freire","year":"2018","unstructured":"Gonzalez-Freire M, Scalzo P, D\u2019agostino J, Moore ZA, Diaz-Ruiz A, Fabbri E, Zane A, Chen B, Becker KG, Lehrmann E, Zukley L, Chia CW, Tanaka T, Coen PM, Bernier M, De Cabo R, Ferrucci L (2018) Skeletal muscle ex vivo mitochondrial respiration parallels decline in vivo oxidative capacity, Cardiorespiratory Fitness, and muscle strength: the Baltimore Longitudinal Study of Aging. Aging Cell 17(2):e12725","journal-title":"Aging Cell"},{"key":"1062_CR45","doi-asserted-by":"publisher","first-page":"713","DOI":"10.3389\/fphys.2017.00713","volume":"8","author":"T Groennebaek","year":"2017","unstructured":"Groennebaek T, Vissing K (2017) Impact of resistance training on skeletal muscle mitochondrial Biogenesis, Content, and function. Front Physiol 8:713","journal-title":"Front Physiol"},{"key":"1062_CR46","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.pneurobio.2018.09.003","volume":"177","author":"A Gr\u00fcnewald","year":"2019","unstructured":"Gr\u00fcnewald A, Kumar KR, Sue CM (2019) New insights into the Complex Role of Mitochondria in Parkinson\u2019s Disease. Prog Neurobiol 177:73\u201393","journal-title":"Prog Neurobiol"},{"key":"1062_CR47","doi-asserted-by":"publisher","first-page":"788505","DOI":"10.3389\/fcvm.2021.788505","volume":"8","author":"C Gu","year":"2021","unstructured":"Gu C, Yan J, Zhao L, Wu G, Wang YL (2021) Regulation of mitochondrial dynamics by Aerobic Exercise in Cardiovascular diseases. Front Cardiovasc Med 8:788505","journal-title":"Front Cardiovasc Med"},{"issue":"3","key":"1062_CR48","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/j.molcel.2010.10.021","volume":"40","author":"J-M Heo","year":"2010","unstructured":"Heo J-M, Livnat-Levanon N, Taylor EB, Jones KT, Dephoure N, Ring J, Xie J, Brodsky JL, Madeo F, Gygi SP, Ashrafi K, Glickman MH, Rutter J (2010) A stress-responsive system for mitochondrial protein degradation. Mol Cell 40(3):465\u2013480","journal-title":"Mol Cell"},{"issue":"2","key":"1062_CR49","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1038\/nrm.2017.95","volume":"19","author":"S Herzig","year":"2018","unstructured":"Herzig S, Shaw RJ (2018) Ampk: Guardian of Metabolism and mitochondrial homeostasis. Nat Rev Mol Cell Biol 19(2):121\u2013135","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"7","key":"1062_CR50","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1038\/s41580-019-0101-y","volume":"20","author":"MS Hipp","year":"2019","unstructured":"Hipp MS, Kasturi P, Hartl FU (2019) The Proteostasis Network and its decline in Ageing. Nat Rev Mol Cell Biol 20(7):421\u2013435","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"5","key":"1062_CR51","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/S0092-8674(03)00929-2","volume":"115","author":"K Inoki","year":"2003","unstructured":"Inoki K, Zhu T, Guan K-L (2003) Tsc2 mediates Cellular Energy response to Control Cell Growth and Survival. Cell 115(5):577\u2013590","journal-title":"Cell"},{"issue":"10","key":"1062_CR52","doi-asserted-by":"publisher","first-page":"1698","DOI":"10.3390\/cells11101698","volume":"11","author":"MJ Jackson","year":"2022","unstructured":"Jackson MJ, Pollock N, Staunton C, Jones S, Mcardle A (2022) Redox Control of Signalling Responses to contractile activity and ageing in skeletal muscle. Cells 11(10):1698","journal-title":"Cells"},{"issue":"8","key":"1062_CR53","doi-asserted-by":"publisher","first-page":"962","DOI":"10.3390\/life14080962","volume":"14","author":"I Jeong","year":"2024","unstructured":"Jeong I, Cho E-J, Yook J-S, Choi Y, Park D-H, Kang J-H, Lee S-H, Seo D-Y, Jung S-J, Kwak H-B (2024) Mitochondrial adaptations in aging skeletal muscle: implications for Resistance Exercise Training to treat Sarcopenia. Life 14(8):962","journal-title":"Life"},{"issue":"6165","key":"1062_CR54","doi-asserted-by":"publisher","first-page":"1524","DOI":"10.1126\/science.1244360","volume":"342","author":"SC Johnson","year":"2013","unstructured":"Johnson SC, Yanos ME, Kayser E-B, Quintana A, Sangesland M, Castanza A, Uhde L, Hui J, Wall VZ, Gagnidze A, Oh K, Wasko BM, Ramos FJ, Palmiter RD, Rabinovitch PS, Morgan PG, Sedensky MM, Kaeberlein M (2013) Mtor Inhibition alleviates mitochondrial disease in a mouse model of Leigh Syndrome. Science 342(6165):1524\u20131528","journal-title":"Science"},{"issue":"18","key":"1062_CR55","doi-asserted-by":"publisher","first-page":"5105","DOI":"10.1113\/JP270659","volume":"594","author":"A-M Joseph","year":"2016","unstructured":"Joseph A-M, Adhihetty PJ, Leeuwenburgh C (2016) Beneficial effects of Exercise on Age-related mitochondrial dysfunction and oxidative stress in skeletal muscle. J Physiol 594(18):5105\u20135123","journal-title":"J Physiol"},{"issue":"2","key":"1062_CR56","doi-asserted-by":"publisher","first-page":"110","DOI":"10.18632\/aging.100723","volume":"7","author":"F Kalfalah","year":"2015","unstructured":"Kalfalah F, Seggewi\u00df S, Walter R, Tigges J, Moreno-Villanueva M, B\u00fcrkle A, Ohse S, Busch H, Boerries M, Hildebrandt B, Royer-Pokora B, Boege F (2015) Structural chromosome abnormalities, increased DNA strand breaks and DNA strand Break Repair Deficiency in dermal fibroblasts from Old Female Human donors. Aging 7(2):110\u2013122","journal-title":"Aging"},{"issue":"2","key":"1062_CR57","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.cmet.2017.07.007","volume":"26","author":"NA Khan","year":"2017","unstructured":"Khan NA, Nikkanen J, Yatsuga S, Jackson C, Wang L, Pradhan S, Kivel\u00e4 R, Pessia A, Velagapudi V, Suomalainen A (2017) Mtorc1 regulates mitochondrial Integrated stress response and mitochondrial myopathy progression. Cell Metab 26(2):419\u2013428e415","journal-title":"Cell Metab"},{"key":"1062_CR58","doi-asserted-by":"crossref","unstructured":"Kraig E, Linehan LA, Liang H, Romo TQ, Liu Q, Wu Y, Benavides AD, Curiel TJ, Javors MA, Musi N, Chiodo L, Koek W, Gelfond JaL, Kellogg DL Jr. 2018. A Randomized Control Trial to establish the feasibility and Safety of Rapamycin Treatment in an older human cohort: immunological, physical performance, and Cognitive effects. Exp Gerontol 105: 53\u201369","DOI":"10.1016\/j.exger.2017.12.026"},{"key":"1062_CR59","doi-asserted-by":"crossref","unstructured":"Kumar, V., Chang, H., Reiter, D. A., Bradley, D. P., Belury, M., Mccormack, S. E.& Raman, S. V. 2017. Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring\u226aEm\u226bin Vivo\u226a\/Em\u226b Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle. Journal of Visualized Experiments (119)","DOI":"10.3791\/54977"},{"issue":"38","key":"1062_CR60","doi-asserted-by":"publisher","first-page":"E8844","DOI":"10.1073\/pnas.1721136115","volume":"115","author":"K-S Lee","year":"2018","unstructured":"Lee K-S, Huh S, Lee S, Wu Z, Kim A-K, Kang H-Y, Lu B (2018) Altered Er\u2013Mitochondria Contact impacts Mitochondria Calcium Homeostasis and contributes to neurodegeneration in Vivo in Disease models. Proc Natl Acad Sci 115(38):E8844\u2013E8853","journal-title":"Proc Natl Acad Sci"},{"issue":"11","key":"1062_CR61","doi-asserted-by":"publisher","first-page":"1765","DOI":"10.1038\/cdd.2016.65","volume":"23","author":"Z Li","year":"2016","unstructured":"Li Z, Zhang W, Chen Y, Guo W, Zhang J, Tang H, Xu Z, Zhang H, Tao Y, Wang F, Jiang Y, Sun FL, Mao Z (2016) Impaired DNA double-strand break repair contributes to the Age-Associated rise of genomic instability in humans. Cell Death Differ 23(11):1765\u20131777","journal-title":"Cell Death Differ"},{"issue":"9","key":"1062_CR62","doi-asserted-by":"publisher","first-page":"2266","DOI":"10.1016\/j.bbadis.2017.05.022","volume":"1863","author":"H Li","year":"2017","unstructured":"Li H, Shen L, Hu P, Huang R, Cao Y, Deng J, Yuan W, Liu D, Yang J, Gu H, Bai Y (2017) Aging-Associated mitochondrial DNA mutations alter oxidative phosphorylation Machinery and cause mitochondrial dysfunctions. Biochim Biophys Acta Mol Basis Dis 1863(9):2266\u20132273","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"issue":"5","key":"1062_CR63","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1002\/1873-3468.13663","volume":"594","author":"X Liu","year":"2020","unstructured":"Liu X, Liao X, Rao X, Wang B, Zhang J, Xu G, Jiang X, Qin X, Chen C, Zou Z (2020) The lysosomal membrane protein Lamp-2 is dispensable for Pink1\/Parkin-Mediated Mitophagy. FEBS Lett 594(5):823\u2013840","journal-title":"FEBS Lett"},{"issue":"6","key":"1062_CR64","first-page":"1194","volume":"153","author":"C L\u00f3pez-Ot\u00edn","year":"2013","unstructured":"L\u00f3pez-Ot\u00edn C, Blasco MA, Partridge L, Serrano M, Kroemer G (2013) Hallm Aging Cell 153(6):1194\u20131217","journal-title":"Hallm Aging Cell"},{"key":"1062_CR65","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.redox.2015.05.006","volume":"5","author":"D Louren\u00e7o","year":"2015","unstructured":"Louren\u00e7o D, Santos S, Baraibar MA, Lundberg S, Eeg-Olofsson O, Larsson L, Friguet B (2015) Oxidative proteome alterations during skeletal muscle ageing. Redox Biol 5:267\u2013274","journal-title":"Redox Biol"},{"issue":"10","key":"1062_CR66","doi-asserted-by":"publisher","first-page":"2288","DOI":"10.1016\/j.biocel.2013.06.024","volume":"45","author":"E Marzetti","year":"2013","unstructured":"Marzetti E, Calvani R, Cesari M, Buford TW, Lorenzi M, Behnke BJ, Leeuwenburgh C (2013) Mitochondrial dysfunction and Sarcopenia of Aging: from signaling pathways to clinical trials. Int J Biochem Cell Biol 45(10):2288\u20132301","journal-title":"Int J Biochem Cell Biol"},{"issue":"6","key":"1062_CR67","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1016\/j.cmet.2018.05.011","volume":"27","author":"MP Mattson","year":"2018","unstructured":"Mattson MP, Arumugam TV (2018) Hallmarks of Brain Aging: adaptive and pathological modification by Metabolic States. Cell Metabol 27(6):1176\u20131199","journal-title":"Cell Metabol"},{"key":"1062_CR68","doi-asserted-by":"crossref","unstructured":"Maynard S, Fang EF, Scheibye-Knudsen M, Croteau DL, Bohr VA (2015) DNA damage, DNA repair, aging, and Neurodegeneration. Cold Spring Harb Perspect Med 5(10)","DOI":"10.1101\/cshperspect.a025130"},{"key":"1062_CR69","doi-asserted-by":"publisher","first-page":"234","DOI":"10.17576\/geo-2021-1703-17","volume":"17","author":"NNF Md Nor","year":"2021","unstructured":"Md Nor NNF, Ghazali S (2021) Malaysia towards an Ageing Country (Geografia Online. Malaysian J Soc Space 17:234\u2013245","journal-title":"Malaysian J Soc Space"},{"key":"1062_CR70","doi-asserted-by":"crossref","unstructured":"Michael, Mcarthur K, Metcalf D, Rachael J, Marco, Mark, Bedoui S, Lessene G, Matthew D (2014) & Benjamin. Apoptotic Caspases Suppress Mtdna-Induced Sting-Mediated Type I Ifn Production. Cell 159(7): 1549\u20131562","DOI":"10.1016\/j.cell.2014.11.036"},{"issue":"1","key":"1062_CR71","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1038\/s41467-017-01401-x","volume":"8","author":"T Moiseeva","year":"2017","unstructured":"Moiseeva T, Hood B, Schamus S, O\u2019connor MJ, Conrads TP, Bakkenist CJ (2017) Atr kinase inhibition induces unscheduled origin firing through a Cdc7-Dependent Association between gins and and-1. Nat Commun 8(1):1392","journal-title":"Nat Commun"},{"issue":"6","key":"1062_CR72","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1038\/s42255-022-00591-z","volume":"4","author":"MP Murphy","year":"2022","unstructured":"Murphy MP, Bayir H, Belousov V, Chang CJ, Davies KJA, Davies MJ, Dick TP, Finkel T, Forman HJ, Janssen-Heininger Y, Gems D, Kagan VE, Kalyanaraman B, Larsson N-G, Milne GL, Nystr\u00f6m T, Poulsen HE, Radi R, Van Remmen H, Schumacker PT, Thornalley PJ, Toyokuni S, Winterbourn CC, Yin H, Halliwell B (2022) Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo. Nat Metabolism 4(6):651\u2013662","journal-title":"Nat Metabolism"},{"issue":"3","key":"1062_CR73","doi-asserted-by":"publisher","first-page":"e104705","DOI":"10.15252\/embj.2020104705","volume":"40","author":"M Onishi","year":"2021","unstructured":"Onishi M, Yamano K, Sato M, Matsuda N, Okamoto K (2021) Molecular mechanisms and physiological functions of Mitophagy. EMBO J 40(3):e104705","journal-title":"EMBO J"},{"issue":"3","key":"1062_CR74","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1007\/s13539-014-0146-x","volume":"5","author":"MJ Ormsbee","year":"2014","unstructured":"Ormsbee MJ, Prado CM, Ilich JZ, Purcell S, Siervo M, Folsom A, Panton L (2014) Osteosarcopenic obesity: the role of bone, muscle, and Fat on Health. J Cachexia Sarcopenia Muscle 5(3):183\u2013192","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"1","key":"1062_CR75","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/s13539-012-0079-1","volume":"4","author":"SS Patel","year":"2013","unstructured":"Patel SS, Molnar MZ, Tayek JA, Ix JH, Noori N, Benner D, Heymsfield S, Kopple JD, Kovesdy CP, Kalantar-Zadeh K (2013) Serum creatinine as a marker of muscle Mass in chronic kidney disease: results of a cross-sectional study and review of literature. J Cachexia Sarcopenia Muscle 4(1):19\u201329","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"1062_CR76","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.pharmthera.2018.07.001","volume":"192","author":"T Pathak","year":"2018","unstructured":"Pathak T, Trebak M (2018) Mitochondrial Ca2\u2009+\u2009signaling. Pharmacol Ther 192:112\u2013123","journal-title":"Pharmacol Ther"},{"key":"1062_CR77","doi-asserted-by":"crossref","unstructured":"Paulussen KJM, Mckenna CF, Beals JW, Wilund KR, Salvador AF, Burd NA (2021) Anabolic Resistance of Muscle Protein Turnover Comes in Various Shapes and Sizes. 8.","DOI":"10.3389\/fnut.2021.615849"},{"issue":"1","key":"1062_CR78","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1002\/rco2.29","volume":"4","author":"G Pharaoh","year":"2021","unstructured":"Pharaoh G, Brown J, Ranjit R, Ungvari Z, Van Remmen H (2021) Reduced Adenosine Diphosphate sensitivity in skeletal muscle Mitochondria increases reactive Oxygen species production in mouse models of aging and oxidative stress but Not Denervation. JCSM Rapid Commun 4(1):75\u201389","journal-title":"JCSM Rapid Commun"},{"issue":"3","key":"1062_CR79","doi-asserted-by":"publisher","first-page":"e1003389","DOI":"10.1371\/journal.pgen.1003389","volume":"9","author":"BE Phillips","year":"2013","unstructured":"Phillips BE, Williams JP, Gustafsson T, Bouchard C, Rankinen T, Knudsen S, Smith K, Timmons JA, Atherton PJ (2013) Molecular networks of human muscle adaptation to Exercise and Age. PLoS Genet 9(3):e1003389","journal-title":"PLoS Genet"},{"issue":"10","key":"1062_CR80","doi-asserted-by":"publisher","first-page":"4653","DOI":"10.1007\/s00018-021-03807-9","volume":"78","author":"FA Rahman","year":"2021","unstructured":"Rahman FA, Quadrilatero J (2021) Mitochondrial network remodeling: an important feature of myogenesis and skeletal muscle regeneration. Cell Mol Life Sci 78(10):4653\u20134675","journal-title":"Cell Mol Life Sci"},{"issue":"1\u20132","key":"1062_CR81","first-page":"202","volume":"49","author":"L Ramy, Ghobry","year":"2020","unstructured":"Ramy, Ghobry L, Wassef O, Connie, Kalantar-Zadeh K (2020) A practical Approach to Nutrition, protein-energy wasting, Sarcopenia, and Cachexia in patients with chronic kidney disease. Blood Purif 49(1\u20132):202\u2013211","journal-title":"Blood Purif"},{"key":"1062_CR82","doi-asserted-by":"crossref","unstructured":"Reggiani C, Marcucci L (2022) A Controversial Issue: Can Mitochondria Modulate Cytosolic Calcium and Contraction of Skeletal Muscle Fibers? Journal of General Physiology 154(9)","DOI":"10.1085\/jgp.202213167"},{"issue":"2","key":"1062_CR83","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.cmet.2007.01.008","volume":"5","author":"RM Reznick","year":"2007","unstructured":"Reznick RM, Zong H, Li J, Morino K, Moore IK, Yu HJ, Liu Z-X, Dong J, Mustard KJ, Hawley SA, Befroy D, Pypaert M, Hardie DG, Young LH, Shulman GI (2007) Aging-Associated reductions in Amp-activated protein kinase activity and mitochondrial Biogenesis. Cell Metabol 5(2):151\u2013156","journal-title":"Cell Metabol"},{"issue":"7","key":"1062_CR84","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1111\/febs.14336","volume":"285","author":"CE Rodger","year":"2018","unstructured":"Rodger CE, Mcwilliams TG, Ganley IG (2018) Mammalian mitophagy \u2013 from in vitro molecules to in vivo models. FEBS J 285(7):1185\u20131202","journal-title":"FEBS J"},{"key":"1062_CR85","doi-asserted-by":"crossref","unstructured":"Rooyackers OE, Adey DB, Ades PA, Nair KS (1996) Effect of Age on <\u2009I\u2009>\u2009in Vivo\u2009Rates of Mitochondrial Protein Synthesis in Human Skeletal Muscle. Proceedings of the National Academy of Sciences 93(26): 15364\u201315369","DOI":"10.1073\/pnas.93.26.15364"},{"issue":"3","key":"1062_CR86","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.cger.2011.03.003","volume":"27","author":"IH Rosenberg","year":"2011","unstructured":"Rosenberg IH (2011) Sarcopenia: origins and clinical relevance. Clin Geriatr Med 27(3):337\u2013339","journal-title":"Clin Geriatr Med"},{"issue":"4","key":"1062_CR87","doi-asserted-by":"publisher","first-page":"488","DOI":"10.3390\/biom12040488","volume":"12","author":"D Rossi","year":"2022","unstructured":"Rossi D, Pierantozzi E, Amadsun DO, Buonocore S, Rubino EM, Sorrentino V (2022) The sarcoplasmic reticulum of skeletal muscle cells: a labyrinth of membrane contact sites. Biomolecules 12(4):488","journal-title":"Biomolecules"},{"issue":"5","key":"1062_CR88","doi-asserted-by":"publisher","first-page":"e10778","DOI":"10.1371\/journal.pone.0010778","volume":"5","author":"A Safdar","year":"2010","unstructured":"Safdar A, Hamadeh MJ, Kaczor JJ, Raha S, Debeer J, Tarnopolsky MA (2010) Aberrant mitochondrial homeostasis in the skeletal muscle of sedentary older adults. PLoS ONE 5(5):e10778","journal-title":"PLoS ONE"},{"issue":"3","key":"1062_CR89","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1016\/j.immuni.2015.02.002","volume":"42","author":"L Samuel","year":"2015","unstructured":"Samuel L, Navdeep (2015) Mitochondria in the regulation of Innate and adaptive immunity. Immunity 42(3):406\u2013417","journal-title":"Immunity"},{"issue":"6","key":"1062_CR90","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1016\/j.cell.2017.02.004","volume":"168","author":"RA Saxton","year":"2017","unstructured":"Saxton RA, Sabatini DM (2017) Mtor Signaling in Growth, Metabolism, and Disease. Cell 168(6):960\u2013976","journal-title":"Cell"},{"issue":"3","key":"1062_CR91","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.molmed.2017.01.003","volume":"23","author":"D Sebastian","year":"2017","unstructured":"Sebastian D, Palacin M, Zorzano A (2017) Mitochondrial dynamics: coupling mitochondrial fitness with healthy aging. Trends Mol Med 23(3):201\u2013215","journal-title":"Trends Mol Med"},{"issue":"7722","key":"1062_CR92","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1038\/s41586-018-0448-9","volume":"561","author":"DA Sliter","year":"2018","unstructured":"Sliter DA, Martinez J, Hao L, Chen X, Sun N, Fischer TD, Burman JL, Li Y, Zhang Z, Narendra DP, Cai H, Borsche M, Klein C, Youle RJ (2018) Parkin and Pink1 mitigate Sting-Induced inflammation. Nature 561(7722):258\u2013262","journal-title":"Nature"},{"key":"1062_CR93","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.brainres.2014.11.013","volume":"1594","author":"L Song","year":"2015","unstructured":"Song L, Cortopassi G (2015) Mitochondrial complex I defects increase ubiquitin in Substantia Nigra. Brain Res 1594:82\u201391","journal-title":"Brain Res"},{"issue":"12","key":"1062_CR94","doi-asserted-by":"publisher","first-page":"4102","DOI":"10.1080\/15548627.2021.1904488","volume":"17","author":"H Song","year":"2021","unstructured":"Song H, Tian X, Liu D, Liu M, Liu Y, Liu J, Mei Z, Yan C, Han Y (2021) Creg1 improves the capacity of the skeletal muscle response to Exercise endurance Via Modulation of Mitophagy. Autophagy 17(12):4102\u20134118","journal-title":"Autophagy"},{"key":"1062_CR95","doi-asserted-by":"crossref","unstructured":"Stagni V, Ferri A, Cirotti C, Baril\u00e0 D (2021) Atm kinase-dependent regulation of Autophagy: a key player in Senescence? Front Cell Dev Biology 8","DOI":"10.3389\/fcell.2020.599048"},{"issue":"6","key":"1062_CR96","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1016\/j.cmet.2018.04.011","volume":"27","author":"T Suhm","year":"2018","unstructured":"Suhm T, Kaimal JM, Dawitz H, Peselj C, Masser AE, Hanz\u00e9n S, Ambro\u017ei\u010d M, Smialowska A, Bj\u00f6rck ML, Brzezinski P, Nystr\u00f6m T, B\u00fcttner S, Andr\u00e9asson C, Ott M (2018) Mitochondrial translation efficiency controls cytoplasmic protein homeostasis. Cell Metabol 27(6):1309\u20131322e1306","journal-title":"Cell Metabol"},{"issue":"6","key":"1062_CR97","doi-asserted-by":"publisher","first-page":"L1049","DOI":"10.1152\/ajplung.00244.2018","volume":"316","author":"R Summer","year":"2019","unstructured":"Summer R, Shaghaghi H, Schriner D, Roque W, Sales D, Cuevas-Mora K, Desai V, Bhushan A, Ramirez MI, Romero F (2019) Activation of the Mtorc1\/Pgc-1 Axis promotes mitochondrial Biogenesis and induces Cellular Senescence in the lung epithelium. Am J Physiol Lung Cell Mol Physiol 316(6):L1049\u2013l1060","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"4","key":"1062_CR98","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1093\/geront\/gnv153","volume":"56","author":"NP Tey","year":"2016","unstructured":"Tey NP, Siraj SB, Kamaruzzaman SB, Chin AV, Tan MP, Sinnappan GS, Muller AM (2016) Aging in multi-ethnic Malaysia. Gerontologist 56(4):603\u2013609","journal-title":"Gerontologist"},{"issue":"1","key":"1062_CR99","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1074\/mcp.M113.032698","volume":"13","author":"L Th\u00e9ron","year":"2014","unstructured":"Th\u00e9ron L, Gueugneau M, Coudy C, Viala D, Bijlsma A, Butler-Browne G, Maier A, B\u00e9chet D, Chambon C (2014) Label-free quantitative protein profiling of Vastus Lateralis muscle during human aging. Mol Cell Proteom 13(1):283\u2013294","journal-title":"Mol Cell Proteom"},{"key":"1062_CR100","doi-asserted-by":"crossref","unstructured":"Timothy S, Thurl A, Seong, Balderas E David, Katherine, Anne, Brian & David. 2011. Mtor Complex 1 regulates Lipin 1 localization to control the srebp pathway. Cell 146(3): 408\u2013420","DOI":"10.1016\/j.cell.2011.06.034"},{"issue":"6270","key":"1062_CR101","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1126\/science.aab4138","volume":"351","author":"EQ Toyama","year":"2016","unstructured":"Toyama EQ, Herzig S, Courchet J, Lewis TL, Los\u00f3n OC, Hellberg K, Young NP, Chen H, Polleux F, Chan DC, Shaw RJ (2016) Amp-activated protein kinase mediates mitochondrial fission in response to energy stress. Science 351(6270):275\u2013281","journal-title":"Science"},{"issue":"10","key":"1062_CR102","doi-asserted-by":"publisher","first-page":"1757","DOI":"10.1080\/15548627.2019.1596477","volume":"15","author":"EN Tsakiri","year":"2019","unstructured":"Tsakiri EN, Gumeni S, Vougas K, Pendin D, Papassideri I, Daga A, Gorgoulis V, Juh\u00e1sz G, Scorrano L, Trougakos IP (2019) Proteasome dysfunction induces excessive Proteome instability and loss of Mitostasis that can be mitigated by enhancing mitochondrial Fusion or Autophagy. Autophagy 15(10):1757\u20131773","journal-title":"Autophagy"},{"issue":"1","key":"1062_CR103","doi-asserted-by":"publisher","first-page":"e2531","DOI":"10.1038\/cddis.2016.443","volume":"8","author":"A Ugun-Klusek","year":"2017","unstructured":"Ugun-Klusek A, Tatham MH, Elkharaz J, Constantin-Teodosiu D, Lawler K, Mohamed H, Paine SML, Anderson G, Mayer J, Lowe R, Ellen Billett J, E., Bedford L (2017) Continued 26s proteasome dysfunction in mouse brain cortical neurons impairs Autophagy and the Keap1-Nrf2 oxidative defence pathway. Cell Death Dis 8(1):e2531\u2013e2531","journal-title":"Cell Death Dis"},{"issue":"4","key":"1062_CR104","doi-asserted-by":"publisher","first-page":"e0194917","DOI":"10.1371\/journal.pone.0194917","volume":"13","author":"TI Uutela","year":"2018","unstructured":"Uutela TI, Kautiainen HJ, Hakkinen AH (2018) Decreasing muscle performance Associated with increasing Disease activity in patients with rheumatoid arthritis. PLoS ONE 13(4):e0194917","journal-title":"PLoS ONE"},{"issue":"4","key":"1062_CR105","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1007\/s13539-014-0164-8","volume":"5","author":"S Von Haehling","year":"2014","unstructured":"Von Haehling S, Anker SD (2014) Prevalence, incidence and clinical impact of Cachexia: facts and numbers-update 2014. J Cachexia Sarcopenia Muscle 5(4):261\u2013263","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"3","key":"1062_CR106","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1007\/s10067-018-4337-2","volume":"38","author":"O Wada","year":"2019","unstructured":"Wada O, Kurita N, Kamitani T, Nakano N, Mizuno K (2019) Influence of the severity of knee osteoarthritis on the Association between Leg Muscle Mass and quadriceps Strength: the Spss-Ok Study. Clin Rheumatol 38(3):719\u2013725","journal-title":"Clin Rheumatol"},{"key":"1062_CR107","doi-asserted-by":"crossref","unstructured":"Wan W, Hua F, Fang P, Li C, Deng F, Chen S, Ying J, Wang X (2022) Regulation of Mitophagy by Sirtuin Family proteins: a vital role in Aging and Age-Related diseases. Front Aging Neurosci 14","DOI":"10.3389\/fnagi.2022.845330"},{"issue":"7566","key":"1062_CR108","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/nature14859","volume":"524","author":"X Wang","year":"2015","unstructured":"Wang X, Chen XJ (2015) A Cytosolic Network suppressing mitochondria-mediated proteostatic stress and cell death. Nature 524(7566):481\u2013484","journal-title":"Nature"},{"issue":"1","key":"1062_CR109","doi-asserted-by":"publisher","first-page":"103715","DOI":"10.1016\/j.isci.2021.103715","volume":"25","author":"X Wang","year":"2022","unstructured":"Wang X, Middleton FA, Tawil R, Chen XJ (2022) Cytosolic adaptation to Mitochondria-Induced Proteostatic stress causes progressive muscle wasting. iScience 25(1):103715","journal-title":"iScience"},{"issue":"6385","key":"1062_CR110","doi-asserted-by":"publisher","first-page":"eaan4146","DOI":"10.1126\/science.aan4146","volume":"360","author":"H Weidberg","year":"2018","unstructured":"Weidberg H, Amon A (2018) Mitocpr\u2014a Surveillance Pathway that protects Mitochondria in response to protein import stress. Science 360(6385):eaan4146","journal-title":"Science"},{"key":"1062_CR111","doi-asserted-by":"crossref","unstructured":"Wenz T, Rossi SG, Rotundo RL, Spiegelman BM, Moraes CT (2009) Increased Muscle Pgc-1\u03b1 Expression Protects from Sarcopenia and Metabolic Disease During Aging. Proceedings of the National Academy of Sciences 106(48): 20405\u201320410","DOI":"10.1073\/pnas.0911570106"},{"issue":"7548","key":"1062_CR112","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1038\/nature14156","volume":"520","author":"AP West","year":"2015","unstructured":"West AP, Khoury-Hanold W, Staron M, Tal MC, Pineda CM, Lang SM, Bestwick M, Duguay BA, Raimundo N, Macduff DA, Kaech SM, Smiley JR, Means RE, Iwasaki A, Shadel GS (2015) Mitochondrial DNA stress primes the antiviral innate Immune response. Nature 520(7548):553\u2013557","journal-title":"Nature"},{"issue":"2","key":"1062_CR113","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.cmet.2015.11.011","volume":"23","author":"CD Wiley","year":"2016","unstructured":"Wiley CD, Velarde MC, Lecot P, Liu S, Sarnoski EA, Freund A, Shirakawa K, Lim HW, Davis SS, Ramanathan A, Gerencser AA, Verdin E, Campisi J (2016) Mitochondrial dysfunction induces senescence with a distinct secretory phenotype. Cell Metab 23(2):303\u2013314","journal-title":"Cell Metab"},{"issue":"7566","key":"1062_CR114","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1038\/nature14951","volume":"524","author":"L Wrobel","year":"2015","unstructured":"Wrobel L, Topf U, Bragoszewski P, Wiese S, Sztolsztener ME, Oeljeklaus S, Varabyova A, Lirski M, Chroscicki P, Mroczek S, Januszewicz E, Dziembowski A, Koblowska M, Warscheid B, Chacinska A (2015) Mistargeted mitochondrial proteins activate a Proteostatic response in the Cytosol. Nature 524(7566):485\u2013488","journal-title":"Nature"},{"issue":"1","key":"1062_CR115","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s13395-020-00231-8","volume":"10","author":"S Yang","year":"2020","unstructured":"Yang S, Loro E, Wada S, Kim B, Tseng W-J, Li K, Khurana TS, Arany Z (2020) Functional effects of muscle Pgc-1alpha in aged animals. Skelet Muscle 10(1):14","journal-title":"Skelet Muscle"},{"issue":"1","key":"1062_CR116","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1146\/annurev-genet-120417-031501","volume":"52","author":"L Zhang","year":"2018","unstructured":"Zhang L, Vijg J (2018) Somatic mutagenesis in mammals and its implications for Human Disease and Aging. Annu Rev Genet 52(1):397\u2013419","journal-title":"Annu Rev Genet"},{"issue":"6239","key":"1062_CR117","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1126\/science.aaa1356","volume":"I","author":"W Zhang","year":"2015","unstructured":"Zhang W, Li J, Suzuki K, Qu J, Wang P, Zhou J, Liu X, Ren R, Xu X, Ocampo A, Yuan T, Yang J, Li Y, Shi L, Guan D, Pan H, Duan S, Ding Z, Li M, Yi F, Bai R, Wang Y, Chen C, Yang F, Li X, Wang Z, Aizawa E, Goebl A, Soligalla RD, Reddy P, Esteban CR, Tang F, Liu G-H, Belmonte JC (2015) A Werner Syndrome Stem Cell Model unveils heterochromatin alterations as a driver of human aging. Science I(6239):1160\u20131163","journal-title":"Science"},{"issue":"17","key":"1062_CR118","doi-asserted-by":"publisher","first-page":"4411","DOI":"10.1093\/emboj\/cdf445","volume":"21","author":"Q Zhao","year":"2002","unstructured":"Zhao Q (2002) A mitochondrial specific stress response in mammalian cells. EMBO J 21(17):4411\u20134419","journal-title":"EMBO J"}],"container-title":["Journal of Physiology and Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13105-024-01062-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13105-024-01062-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13105-024-01062-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T03:05:43Z","timestamp":1743735943000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13105-024-01062-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":118,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["1062"],"URL":"https:\/\/doi.org\/10.1007\/s13105-024-01062-7","relation":{},"ISSN":["1138-7548","1877-8755"],"issn-type":[{"value":"1138-7548","type":"print"},{"value":"1877-8755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"28 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent statement"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Institutional review board statement"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}