{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T03:36:18Z","timestamp":1789011378916,"version":"build-2803163510"},"reference-count":66,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T00:00:00Z","timestamp":1751500800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T00:00:00Z","timestamp":1751500800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Ministry of Science, Technological Development and Innovations of the Republic of Serbia","award":["451-03-136\/2025-03\/200007"],"award-info":[{"award-number":["451-03-136\/2025-03\/200007"]}]},{"name":"Ministry of Science, Technological Development and Innovations of the Republic of Serbia","award":["451-03-136\/2025-03\/200007"],"award-info":[{"award-number":["451-03-136\/2025-03\/200007"]}]},{"name":"Ministry of Science, Technological Development and Innovations of the Republic of Serbia","award":["451-03-136\/2025-03\/200007"],"award-info":[{"award-number":["451-03-136\/2025-03\/200007"]}]},{"name":"Ministry of Science, Technological Development and Innovations of the Republic of Serbia","award":["451-03-136\/2025-03\/200007"],"award-info":[{"award-number":["451-03-136\/2025-03\/200007"]}]},{"name":"Ministry of Science, Technological Development and Innovations of the Republic of Serbia","award":["451-03-136\/2025-03\/200007"],"award-info":[{"award-number":["451-03-136\/2025-03\/200007"]}]},{"name":"Ministry of Science, Technological Development and Innovations of the Republic of Serbia","award":["451-03-136\/2025-03\/200007"],"award-info":[{"award-number":["451-03-136\/2025-03\/200007"]}]},{"name":"Ministry of Science, Technological Development and Innovations of the Republic of Serbia","award":["451-03-136\/2025-03\/200007"],"award-info":[{"award-number":["451-03-136\/2025-03\/200007"]}]},{"name":"Ministry of Science, Technological Development and Innovations of the Republic of Serbia","award":["451-03-136\/2025-03\/200007"],"award-info":[{"award-number":["451-03-136\/2025-03\/200007"]}]},{"name":"Ministry of Science, Technological Development and Innovations of the Republic of Serbia","award":["451-03-136\/2025-03\/200007"],"award-info":[{"award-number":["451-03-136\/2025-03\/200007"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Physiol Biochem"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1007\/s13105-025-01103-9","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T23:23:44Z","timestamp":1751498624000},"page":"793-813","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Postnatal overfeeding induces gut microbiota disturbances and impairs GPR43\/FIAF\/LPL pathway in the rat model of PCOS"],"prefix":"10.1007","volume":"81","author":[{"given":"Nata\u0161a","family":"Veli\u010dkovi\u0107","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milo\u0161","family":"Vratari\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bojana","family":"Mi\u0107i\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Teofilovi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Radovanovi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofija","family":"Ignjatovi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uro\u0161","family":"Ga\u0161i\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Djordjevic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Djuro","family":"Macut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danijela Vojnovi\u0107","family":"Milutinovi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,3]]},"reference":[{"key":"1103_CR1","doi-asserted-by":"publisher","first-page":"1037696","DOI":"10.3389\/fnut.2022.1037696","volume":"9","author":"P Amiri","year":"2022","unstructured":"Amiri P, Arefhosseini S, Bakhshimoghaddam F, Jamshidi Gurvan H, Hosseini SA (2022) Mechanistic insights into the pleiotropic effects of butyrate as a potential therapeutic agent on NAFLD management: A systematic review. Front Nutr 9:1037696","journal-title":"Front Nutr"},{"issue":"3","key":"1103_CR2","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1055\/s-0034-1371092","volume":"32","author":"AD Anderson","year":"2014","unstructured":"Anderson AD, Solorzano CM, McCartney CR (2014) Childhood obesity and its impact on the development of adolescent PCOS. Semin Reprod Med 32(3):202\u2013213","journal-title":"Semin Reprod Med"},{"issue":"1","key":"1103_CR3","doi-asserted-by":"publisher","first-page":"65","DOI":"10.3164\/jcbn.15-152","volume":"59","author":"A Andoh","year":"2016","unstructured":"Andoh A, Nishida A, Takahashi K, Inatomi O, Imaeda H, Bamba S et al (2016) Comparison of the gut microbial community between obese and lean peoples using 16S gene sequencing in a Japanese population. J Clin Biochem Nutr 59(1):65\u201370","journal-title":"J Clin Biochem Nutr"},{"issue":"1","key":"1103_CR4","doi-asserted-by":"publisher","first-page":"e000352","DOI":"10.1136\/bmjgast-2019-000352","volume":"7","author":"MM Asfari","year":"2020","unstructured":"Asfari MM, Sarmini MT, Baidoun F, Al-Khadra Y, Ezzaizi Y, Dasarathy S et al (2020) Association of non-alcoholic fatty liver disease and polycystic ovarian syndrome. BMJ Open Gastroenterol 7(1):e000352","journal-title":"BMJ Open Gastroenterol"},{"issue":"44","key":"1103_CR5","doi-asserted-by":"publisher","first-page":"15718","DOI":"10.1073\/pnas.0407076101","volume":"101","author":"F Backhed","year":"2004","unstructured":"Backhed F, Ding H, Wang T, Hooper LV, Koh GY, Nagy A et al (2004) The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci USA 101(44):15718\u201315723","journal-title":"Proc Natl Acad Sci USA"},{"issue":"9","key":"1103_CR6","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1016\/j.molmet.2016.06.003","volume":"5","author":"S Bashiardes","year":"2016","unstructured":"Bashiardes S, Shapiro H, Rozin S, Shibolet O, Elinav E (2016) Non-alcoholic fatty liver and the gut microbiota. Mol Metab 5(9):782\u2013794","journal-title":"Mol Metab"},{"issue":"2","key":"1103_CR7","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1128\/mSystems.00857-19","volume":"5","author":"A Benitez-Paez","year":"2020","unstructured":"Benitez-Paez A, Gomez Del Pugar EM, Lopez-Almela I, Moya-Perez A, Codoner-Franch P, Sanz Y (2020) Depletion of Blautia Species in the Microbiota of Obese Children Relates to Intestinal Inflammation and Metabolic Phenotype Worsening. mSystems 5(2):10\u2013128","journal-title":"mSystems"},{"issue":"1","key":"1103_CR8","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/1757-4749-5-10","volume":"5","author":"L Bervoets","year":"2013","unstructured":"Bervoets L, Van Hoorenbeeck K, Kortleven I, Van Noten C, Hens N, Vael C et al (2013) Differences in gut microbiota composition between obese and lean children: a cross-sectional study. Gut Pathog 5(1):10","journal-title":"Gut Pathog"},{"issue":"1","key":"1103_CR9","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1186\/s40168-018-0470-z","volume":"6","author":"NA Bokulich","year":"2018","unstructured":"Bokulich NA, Kaehler BD, Rideout JR, Dillon M, Bolyen E, Knight R et al (2018) Optimizing taxonomic classification of marker-gene amplicon sequences with QIIME 2\u2019s q2-feature-classifier plugin. Microbiome 6(1):90","journal-title":"Microbiome"},{"issue":"8","key":"1103_CR10","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1038\/s41587-019-0209-9","volume":"37","author":"E Bolyen","year":"2019","unstructured":"Bolyen E, Rideout JR, Dillon MR, Bokulich NA, Abnet CC, Al-Ghalith GA et al (2019) Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2. Nat Biotechnol 37(8):852\u2013857","journal-title":"Nat Biotechnol"},{"issue":"7","key":"1103_CR11","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1038\/nmeth.3869","volume":"13","author":"BJ Callahan","year":"2016","unstructured":"Callahan BJ, McMurdie PJ, Rosen MJ, Han AW, Johnson AJ, Holmes SP (2016) DADA2: High-resolution sample inference from Illumina amplicon data. Nat Methods 13(7):581\u2013583","journal-title":"Nat Methods"},{"issue":"9","key":"1103_CR12","doi-asserted-by":"publisher","first-page":"1716","DOI":"10.1136\/gutjnl-2018-316723","volume":"67","author":"PD Cani","year":"2018","unstructured":"Cani PD (2018) Human gut microbiome: hopes, threats and promises. Gut 67(9):1716\u20131725","journal-title":"Gut"},{"issue":"16","key":"1103_CR13","doi-asserted-by":"publisher","first-page":"4027","DOI":"10.1093\/bioinformatics\/btac438","volume":"38","author":"Y Cao","year":"2022","unstructured":"Cao Y, Dong Q, Wang D, Zhang P, Liu Y, Niu C (2022) MicrobiomeMarker: an R\/Bioconductor package for microbiome marker identification and visualization. Bioinformatics 38(16):4027\u20134029","journal-title":"Bioinformatics"},{"key":"1103_CR14","doi-asserted-by":"publisher","first-page":"567654","DOI":"10.3389\/fmicb.2020.567654","volume":"11","author":"X Dai","year":"2020","unstructured":"Dai X, Hou H, Zhang W, Liu T, Li Y, Wang S et al (2020) Microbial Metabolites: Critical Regulators in NAFLD. Front Microbiol 11:567654","journal-title":"Front Microbiol"},{"issue":"10","key":"1103_CR15","doi-asserted-by":"publisher","first-page":"5453","DOI":"10.3390\/ijms25105453","volume":"25","author":"C De Caro","year":"2024","unstructured":"De Caro C, Spagnuolo R, Quirino A, Mazza E, Carrabetta F, Maurotti S et al (2024) Gut Microbiota Profile Changes in Patients with Inflammatory Bowel Disease and Non-Alcoholic Fatty Liver Disease: A Metagenomic Study. Int J Mol Sci 25(10):5453","journal-title":"Int J Mol Sci"},{"key":"1103_CR16","doi-asserted-by":"publisher","first-page":"121982","DOI":"10.1016\/j.jchromb.2020.121982","volume":"1154","author":"M Dei Cas","year":"2020","unstructured":"Dei Cas M, Paroni R, Saccardo A, Casagni E, Arnoldi S, Gambaro V et al (2020) A straightforward LC-MS\/MS analysis to study serum profile of short and medium chain fatty acids. J Chromatogr B Anal Technol Biomed Life Sci 1154:121982","journal-title":"J Chromatogr B Anal Technol Biomed Life Sci"},{"issue":"5","key":"1103_CR17","doi-asserted-by":"publisher","first-page":"1454","DOI":"10.1016\/j.fertnstert.2004.11.070","volume":"83","author":"CM DeUgarte","year":"2005","unstructured":"DeUgarte CM, Bartolucci AA, Azziz R (2005) Prevalence of insulin resistance in the polycystic ovary syndrome using the homeostasis model assessment. Fertil Steril 83(5):1454\u20131460","journal-title":"Fertil Steril"},{"issue":"1","key":"1103_CR18","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.fertnstert.2011.09.024","volume":"97","author":"BC Fauser","year":"2012","unstructured":"Fauser BC, Tarlatzis BC, Rebar RW, Legro RS, Balen AH, Lobo R et al (2012) Consensus on women\u2019s health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE\/ASRM-Sponsored 3rd PCOS Consensus Workshop Group. Fertil Steril 97(1):28\u201338","journal-title":"Fertil Steril"},{"issue":"4","key":"1103_CR19","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1038\/nrendo.2010.217","volume":"7","author":"MO Goodarzi","year":"2011","unstructured":"Goodarzi MO, Dumesic DA, Chazenbalk G, Azziz R (2011) Polycystic ovary syndrome: etiology, pathogenesis and diagnosis. Nat Rev Endocrinol 7(4):219\u2013231","journal-title":"Nat Rev Endocrinol"},{"issue":"4","key":"1103_CR20","doi-asserted-by":"publisher","first-page":"e0153196","DOI":"10.1371\/journal.pone.0153196","volume":"11","author":"Y Guo","year":"2016","unstructured":"Guo Y, Qi Y, Yang X, Zhao L, Wen S, Liu Y et al (2016) Association between Polycystic Ovary Syndrome and Gut Microbiota. PLoS ONE 11(4):e0153196","journal-title":"PLoS ONE"},{"issue":"1","key":"1103_CR21","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.biochi.2011.09.023","volume":"94","author":"A Habbout","year":"2012","unstructured":"Habbout A, Delemasure S, Goirand F, Guilland JC, Chabod F, Sediki M et al (2012) Postnatal overfeeding in rats leads to moderate overweight and to cardiometabolic and oxidative alterations in adulthood. Biochimie 94(1):117\u2013124","journal-title":"Biochimie"},{"issue":"3","key":"1103_CR22","doi-asserted-by":"publisher","first-page":"G329","DOI":"10.1152\/ajpgi.00044.2018","volume":"315","author":"S Hohenester","year":"2018","unstructured":"Hohenester S, Christiansen S, Nagel J, Wimmer R, Artmann R, Denk G et al (2018) Lifestyle intervention for morbid obesity: effects on liver steatosis, inflammation, and fibrosis. Am J Physiol Gastrointest Liver Physiol 315(3):G329\u2013G338","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"1","key":"1103_CR23","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1186\/s12902-023-01456-6","volume":"23","author":"X Hong","year":"2023","unstructured":"Hong X, Guo Z, Yu Q (2023) Hepatic steatosis in women with polycystic ovary syndrome. BMC Endocr Disord 23(1):207","journal-title":"BMC Endocr Disord"},{"issue":"2","key":"1103_CR24","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1007\/s00535-019-01649-8","volume":"55","author":"H Hu","year":"2020","unstructured":"Hu H, Lin A, Kong M, Yao X, Yin M, Xia H et al (2020) Intestinal microbiome and NAFLD: molecular insights and therapeutic perspectives. J Gastroenterol 55(2):142\u2013158","journal-title":"J Gastroenterol"},{"issue":"1","key":"1103_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.aninu.2020.11.005","volume":"7","author":"T Hussain","year":"2021","unstructured":"Hussain T, Murtaza G, Kalhoro DH, Kalhoro MS, Metwally E, Chughtai MI et al (2021) Relationship between gut microbiota and host-metabolism: Emphasis on hormones related to reproductive function. Anim Nutr 7(1):1\u201310","journal-title":"Anim Nutr"},{"issue":"1","key":"1103_CR26","doi-asserted-by":"publisher","first-page":"65","DOI":"10.12938\/bmfh.2019-031","volume":"40","author":"KS Ibrahim","year":"2021","unstructured":"Ibrahim KS, Bourwis N, Dolan S, Lang S, Spencer J, Craft JA (2021) Characterisation of gut microbiota of obesity and type 2 diabetes in a rodent model. Biosci Microbiota Food Health 40(1):65\u201374","journal-title":"Biosci Microbiota Food Health"},{"issue":"1","key":"1103_CR27","doi-asserted-by":"publisher","first-page":"e0245219","DOI":"10.1371\/journal.pone.0245219","volume":"16","author":"B Jobira","year":"2021","unstructured":"Jobira B, Frank DN, Silveira LJ, Pyle L, Kelsey MM, Garcia-Reyes Y et al (2021) Hepatic steatosis relates to gastrointestinal microbiota changes in obese girls with polycystic ovary syndrome. PLoS ONE 16(1):e0245219","journal-title":"PLoS ONE"},{"key":"1103_CR28","doi-asserted-by":"publisher","first-page":"91","DOI":"10.2147\/JHC.S48956","volume":"2","author":"T Kanda","year":"2015","unstructured":"Kanda T, Yokosuka O (2015) The androgen receptor as an emerging target in hepatocellular carcinoma. J Hepatocell Carcinoma 2:91\u201399","journal-title":"J Hepatocell Carcinoma"},{"issue":"1","key":"1103_CR29","doi-asserted-by":"publisher","first-page":"e0146509","DOI":"10.1371\/journal.pone.0146509","volume":"11","author":"ST Kelley","year":"2016","unstructured":"Kelley ST, Skarra DV, Rivera AJ, Thackray VG (2016) The Gut Microbiome Is Altered in a Letrozole-Induced Mouse Model of Polycystic Ovary Syndrome. PLoS ONE 11(1):e0146509","journal-title":"PLoS ONE"},{"key":"1103_CR30","doi-asserted-by":"publisher","first-page":"1835","DOI":"10.3389\/fmicb.2018.01835","volume":"9","author":"ZY Kho","year":"2018","unstructured":"Kho ZY, Lal SK (2018) The Human Gut Microbiome - A Potential Controller of Wellness and Disease. Front Microbiol 9:1835","journal-title":"Front Microbiol"},{"issue":"1","key":"1103_CR31","doi-asserted-by":"publisher","first-page":"19417","DOI":"10.1038\/s41598-020-76474-8","volume":"10","author":"MH Kim","year":"2020","unstructured":"Kim MH, Yun KE, Kim J, Park E, Chang Y, Ryu S et al (2020) Gut microbiota and metabolic health among overweight and obese individuals. Sci Rep 10(1):19417","journal-title":"Sci Rep"},{"issue":"1","key":"1103_CR32","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1111\/j.1600-0757.2011.00398.x","volume":"61","author":"PS Kumar","year":"2013","unstructured":"Kumar PS (2013) Sex and the subgingival microbiome: do female sex steroids affect periodontal bacteria? Periodontol 2000 61(1):103\u201324","journal-title":"Periodontol 2000"},{"key":"1103_CR33","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.3389\/fimmu.2017.01107","volume":"8","author":"AZ Leite","year":"2017","unstructured":"Leite AZ, Rodrigues NC, Gonzaga MI, Paiolo JCC, de Souza CA, Stefanutto NAV et al (2017) Detection of Increased Plasma Interleukin-6 Levels and Prevalence of Prevotella copri and Bacteroides vulgatus in the Feces of Type 2 Diabetes Patients. Front Immunol 8:1107","journal-title":"Front Immunol"},{"issue":"1","key":"1103_CR34","doi-asserted-by":"publisher","first-page":"e0168390","DOI":"10.1371\/journal.pone.0168390","volume":"12","author":"L Lindheim","year":"2017","unstructured":"Lindheim L, Bashir M, Munzker J, Trummer C, Zachhuber V, Leber B et al (2017) Alterations in Gut Microbiome Composition and Barrier Function Are Associated with Reproductive and Metabolic Defects in Women with Polycystic Ovary Syndrome (PCOS): A Pilot Study. PLoS ONE 12(1):e0168390","journal-title":"PLoS ONE"},{"key":"1103_CR35","first-page":"324","volume":"8","author":"R Liu","year":"2017","unstructured":"Liu R, Zhang C, Shi Y, Zhang F, Li L, Wang X et al (2017) Dysbiosis of Gut Microbiota Associated with Clinical Parameters in Polycystic Ovary Syndrome. Front Microbiol 8:324","journal-title":"Front Microbiol"},{"issue":"3","key":"1103_CR36","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1210\/clinem\/dgaa848","volume":"106","author":"K Lull","year":"2021","unstructured":"Lull K, Arffman RK, Sola-Leyva A, Molina NM, Aasmets O, Herzig KH et al (2021) The Gut Microbiome in Polycystic Ovary Syndrome and Its Association with Metabolic Traits. J Clin Endocrinol Metab 106(3):858\u2013871","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"1103_CR37","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1074\/jbc.M506519200","volume":"281","author":"S Mandard","year":"2006","unstructured":"Mandard S, Zandbergen F, van Straten E, Wahli W, Kuipers F, Muller M et al (2006) The fasting-induced adipose factor\/angiopoietin-like protein 4 is physically associated with lipoproteins and governs plasma lipid levels and adiposity. J Biol Chem 281(2):934\u2013944","journal-title":"J Biol Chem"},{"issue":"8","key":"1103_CR38","doi-asserted-by":"publisher","first-page":"3781","DOI":"10.1210\/en.2007-0168","volume":"148","author":"L Manner\u00e5s","year":"2007","unstructured":"Manner\u00e5s L, Cajander S, Holm\u00e4ng A, Seleskovic Z, Lystig T, L\u00f6nn M et al (2007) A new rat model exhibiting both ovarian and metabolic characteristics of polycystic ovary syndrome. Endocrinology 148(8):3781\u20133791","journal-title":"Endocrinology"},{"issue":"3","key":"1103_CR39","doi-asserted-by":"publisher","first-page":"856","DOI":"10.3390\/jcm12030856","volume":"12","author":"R Manzano-Nunez","year":"2023","unstructured":"Manzano-Nunez R, Santana-Dominguez M, Rivera-Esteban J, Sabiote C, Sena E, Banares J et al (2023) Non-Alcoholic Fatty Liver Disease in Patients with Polycystic Ovary Syndrome: A Systematic Review, Meta-Analysis, and Meta-Regression. J Clin Med 12(3):856","journal-title":"J Clin Med"},{"issue":"1","key":"1103_CR40","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.fertnstert.2011.11.036","volume":"97","author":"JC Marshall","year":"2012","unstructured":"Marshall JC, Dunaif A (2012) Should all women with PCOS be treated for insulin resistance? Fertil Steril 97(1):18\u201322","journal-title":"Fertil Steril"},{"issue":"5","key":"1103_CR41","doi-asserted-by":"publisher","first-page":"1714","DOI":"10.1210\/jc.2005-1852","volume":"91","author":"CR McCartney","year":"2006","unstructured":"McCartney CR, Prendergast KA, Chhabra S, Eagleson CA, Yoo RY, Chang RJ et al (2006) The association of obesity and hyperandrogenemia during the pubertal transition in girls: obesity as a potential factor in the genesis of postpubertal hyperandrogenism. J Clin Endocrinol Metab 91(5):1714\u20131722","journal-title":"J Clin Endocrinol Metab"},{"issue":"16","key":"1103_CR42","doi-asserted-by":"publisher","first-page":"8942","DOI":"10.3390\/ijms23168942","volume":"23","author":"B Mi\u0107i\u0107","year":"2022","unstructured":"Mi\u0107i\u0107 B, Teofilovi\u0107 A, Djordjevic A, Veli\u010dkovi\u0107 N, Macut D, Vojnovi\u0107 Milutinovi\u0107 D (2022) AMPK Activation Is Important for the Preservation of Insulin Sensitivity in Visceral, but Not in Subcutaneous Adipose Tissue of Postnatally Overfed Rat Model of Polycystic Ovary Syndrome. Int J Mol Sci 23(16):8942","journal-title":"Int J Mol Sci"},{"issue":"6","key":"1103_CR43","doi-asserted-by":"publisher","first-page":"1586","DOI":"10.3390\/biomedicines11061586","volume":"11","author":"B Mi\u0107i\u0107","year":"2023","unstructured":"Mi\u0107i\u0107 B, Djordjevic A, Veli\u010dkovi\u0107 N, Kova\u010devi\u0107 S, Marti\u0107 T, Macut D et al (2023) AMPK Activation as a Protective Mechanism to Restrain Oxidative Stress in the Insulin-Resistant State in Skeletal Muscle of Rat Model of PCOS Subjected to Postnatal Overfeeding. Biomedicines 11(6):1586","journal-title":"Biomedicines"},{"key":"1103_CR44","doi-asserted-by":"publisher","first-page":"1203902","DOI":"10.3389\/fmicb.2023.1203902","volume":"14","author":"Q Min","year":"2023","unstructured":"Min Q, Geng H, Gao Q, Xu M (2023) The association between gut microbiome and PCOS: evidence from meta-analysis and two-sample mendelian randomization. Front Microbiol 14:1203902","journal-title":"Front Microbiol"},{"key":"1103_CR45","doi-asserted-by":"publisher","first-page":"757718","DOI":"10.3389\/fcimb.2021.757718","volume":"11","author":"K Nie","year":"2021","unstructured":"Nie K, Ma K, Luo W, Shen Z, Yang Z, Xiao M et al (2021) Roseburia intestinalis: A Beneficial Gut Organism From the Discoveries in Genus and Species. Front Cell Infect Microbiol 11:757718","journal-title":"Front Cell Infect Microbiol"},{"key":"1103_CR46","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.mce.2014.08.013","volume":"399","author":"M Nikoli\u0107","year":"2015","unstructured":"Nikoli\u0107 M, Macut D, Djordjevic A, Veli\u010dkovi\u0107 N, Nestorovi\u0107 N, Bursa\u0107 B et al (2015) Possible involvement of glucocorticoids in 5alpha-dihydrotestosterone-induced PCOS-like metabolic disturbances in the rat visceral adipose tissue. Mol Cell Endocrinol 399:22\u201331","journal-title":"Mol Cell Endocrinol"},{"key":"1103_CR47","doi-asserted-by":"publisher","first-page":"1111911","DOI":"10.3389\/fmicb.2023.1111911","volume":"14","author":"S Qu","year":"2023","unstructured":"Qu S, Zheng Y, Huang Y, Feng Y, Xu K, Zhang W et al (2023) Excessive consumption of mucin by over-colonized Akkermansia muciniphila promotes intestinal barrier damage during malignant intestinal environment. Front Microbiol 14:1111911","journal-title":"Front Microbiol"},{"issue":"1","key":"1103_CR48","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1111\/1462-2920.13463","volume":"19","author":"A Riva","year":"2017","unstructured":"Riva A, Borgo F, Lassandro C, Verduci E, Morace G, Borghi E et al (2017) Pediatric obesity is associated with an altered gut microbiota and discordant shifts in Firmicutes populations. Environ Microbiol 19(1):95\u2013105","journal-title":"Environ Microbiol"},{"issue":"7","key":"1103_CR49","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.3390\/nu15071550","volume":"15","author":"F Salas-Perez","year":"2023","unstructured":"Salas-Perez F, Assmann TS, Ramos-Lopez O, Martinez JA, Riezu-Boj JI, Milagro FI (2023) Crosstalk between Gut Microbiota and Epigenetic Markers in Obesity Development: Relationship between Ruminococcus, BMI, and MACROD2\/SEL1L2 Methylation. Nutrients 15(7):1550","journal-title":"Nutrients"},{"issue":"4","key":"1103_CR50","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1007\/s11154-019-09512-0","volume":"20","author":"M Schoeler","year":"2019","unstructured":"Schoeler M, Caesar R (2019) Dietary lipids, gut microbiota and lipid metabolism. Rev Endocr Metab Disord 20(4):461\u2013472","journal-title":"Rev Endocr Metab Disord"},{"issue":"6","key":"1103_CR51","doi-asserted-by":"publisher","first-page":"R60","DOI":"10.1186\/gb-2011-12-6-r60","volume":"12","author":"N Segata","year":"2011","unstructured":"Segata N, Izard J, Waldron L, Gevers D, Miropolsky L, Garrett WS et al (2011) Metagenomic biomarker discovery and explanation. Genome Biol 12(6):R60","journal-title":"Genome Biol"},{"issue":"2","key":"1103_CR52","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1530\/JOE-21-0040","volume":"250","author":"T Seidu","year":"2021","unstructured":"Seidu T, McWhorter P, Myer J, Alamgir R, Eregha N, Bogle D et al (2021) DHT causes liver steatosis via transcriptional regulation of SCAP in normal weight female mice. J Endocrinol 250(2):49\u201365","journal-title":"J Endocrinol"},{"issue":"4","key":"1103_CR53","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1016\/j.celrep.2017.03.080","volume":"19","author":"SS Seregin","year":"2017","unstructured":"Seregin SS, Golovchenko N, Schaf B, Chen J, Pudlo NA, Mitchell J et al (2017) NLRP6 Protects Il10(-\/-) Mice from Colitis by Limiting Colonization of Akkermansia muciniphila. Cell Rep 19(4):733\u2013745","journal-title":"Cell Rep"},{"issue":"10","key":"1103_CR54","doi-asserted-by":"publisher","first-page":"2045","DOI":"10.3390\/nu14102045","volume":"14","author":"LL Souza","year":"2022","unstructured":"Souza LL, Moura EG, Lisboa PC (2022) Litter Size Reduction as a Model of Overfeeding during Lactation and Its Consequences for the Development of Metabolic Diseases in the Offspring. Nutrients 14(10):2045","journal-title":"Nutrients"},{"issue":"1","key":"1103_CR55","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/0003-2697(78)90327-5","volume":"86","author":"T Spector","year":"1978","unstructured":"Spector T (1978) Refinement of the coomassie blue method of protein quantitation. A simple and linear spectrophotometric assay for less than or equal to 05 to 50 microgram of protein. Anal Biochem 86(1):142\u20136","journal-title":"Anal Biochem"},{"key":"1103_CR56","doi-asserted-by":"publisher","first-page":"117156","DOI":"10.1016\/j.biopha.2024.117156","volume":"178","author":"C Sun","year":"2024","unstructured":"Sun C, Xiong X, Liu M, Liang Q, Zhao Q, Wei G et al (2024) Bacteroides ovatus alleviates high-fat and high-cholesterol -induced nonalcoholic fatty liver disease via gut-liver axis. Biomed Pharmacother 178:117156","journal-title":"Biomed Pharmacother"},{"issue":"4","key":"1103_CR57","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.1210\/jc.2017-02153","volume":"103","author":"PJ Torres","year":"2018","unstructured":"Torres PJ, Siakowska M, Banaszewska B, Pawelczyk L, Duleba AJ, Kelley ST et al (2018) Gut Microbial Diversity in Women With Polycystic Ovary Syndrome Correlates With Hyperandrogenism. J Clin Endocrinol Metab 103(4):1502\u20131511","journal-title":"J Clin Endocrinol Metab"},{"issue":"7","key":"1103_CR58","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1038\/s41575-018-0011-z","volume":"15","author":"A Tripathi","year":"2018","unstructured":"Tripathi A, Debelius J, Brenner DA, Karin M, Loomba R, Schnabl B et al (2018) The gut-liver axis and the intersection with the microbiome. Nat Rev Gastroenterol Hepatol 15(7):397\u2013411","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"1103_CR59","doi-asserted-by":"publisher","first-page":"154652","DOI":"10.1016\/j.phymed.2023.154652","volume":"110","author":"Z Wang","year":"2023","unstructured":"Wang Z, Sun Y, Han Y, Chen X, Gong P, Zhai P et al (2023) Eucommia bark\/leaf extract improves HFD-induced lipid metabolism disorders via targeting gut microbiota to activate the Fiaf-LPL gut-liver axis and SCFAs-GPR43 gut-fat axis. Phytomedicine 110:154652","journal-title":"Phytomedicine"},{"key":"1103_CR60","doi-asserted-by":"publisher","first-page":"964847","DOI":"10.3389\/fmicb.2022.964847","volume":"13","author":"Y Wu","year":"2022","unstructured":"Wu Y, Peng X, Li X, Li D, Tan Z, Yu R (2022) Sex hormones influence the intestinal microbiota composition in mice. Front Microbiol 13:964847","journal-title":"Front Microbiol"},{"issue":"1","key":"1103_CR61","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s12263-021-00703-6","volume":"17","author":"Z Xu","year":"2022","unstructured":"Xu Z, Jiang W, Huang W, Lin Y, Chan FKL, Ng SC (2022) Gut microbiota in patients with obesity and metabolic disorders - a systematic review. Genes Nutr 17(1):2","journal-title":"Genes Nutr"},{"issue":"1","key":"1103_CR62","doi-asserted-by":"publisher","first-page":"22184","DOI":"10.1038\/s41598-022-25041-4","volume":"12","author":"Z Yu","year":"2022","unstructured":"Yu Z, Qin E, Cheng S, Yang H, Liu R, Xu T et al (2022) Gut microbiome in PCOS associates to serum metabolomics: a cross-sectional study. Sci Rep 12(1):22184","journal-title":"Sci Rep"},{"key":"1103_CR63","doi-asserted-by":"publisher","first-page":"175","DOI":"10.3389\/fmicb.2019.00175","volume":"10","author":"F Zhang","year":"2019","unstructured":"Zhang F, Ma T, Cui P, Tamadon A, He S, Huo C et al (2019) Diversity of the Gut Microbiota in Dihydrotestosterone-Induced PCOS Rats and the Pharmacologic Effects of Diane-35, Probiotics, and Berberine. Front Microbiol 10:175","journal-title":"Front Microbiol"},{"key":"1103_CR64","doi-asserted-by":"publisher","first-page":"104359","DOI":"10.1016\/j.micpath.2020.104359","volume":"147","author":"J Zhang","year":"2020","unstructured":"Zhang J, Luo D, Lin Z, Zhou W, Rao J, Li Y et al (2020) Dysbiosis of gut microbiota in adult idiopathic membranous nephropathy with nephrotic syndrome. Microb Pathog 147:104359","journal-title":"Microb Pathog"},{"issue":"5","key":"1103_CR65","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1007\/s00449-020-02320-w","volume":"44","author":"Y Zheng","year":"2021","unstructured":"Zheng Y, Yu J, Liang C, Li S, Wen X, Li Y (2021) Characterization on gut microbiome of PCOS rats and its further design by shifts in high-fat diet and dihydrotestosterone induction in PCOS rats. Bioprocess Biosyst Eng 44(5):953\u2013964","journal-title":"Bioprocess Biosyst Eng"},{"key":"1103_CR66","doi-asserted-by":"publisher","first-page":"232","DOI":"10.3389\/fmicb.2019.00232","volume":"10","author":"W Zhou","year":"2019","unstructured":"Zhou W, Xu H, Zhan L, Lu X, Zhang L (2019) Dynamic Development of Fecal Microbiome During the Progression of Diabetes Mellitus in Zucker Diabetic Fatty Rats. Front Microbiol 10:232","journal-title":"Front Microbiol"}],"container-title":["Journal of Physiology and Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13105-025-01103-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13105-025-01103-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13105-025-01103-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T01:46:25Z","timestamp":1757209585000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13105-025-01103-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,3]]},"references-count":66,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["1103"],"URL":"https:\/\/doi.org\/10.1007\/s13105-025-01103-9","relation":{},"ISSN":["1138-7548","1877-8755"],"issn-type":[{"value":"1138-7548","type":"print"},{"value":"1877-8755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,3]]},"assertion":[{"value":"29 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical trial number"}}]}}