{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T06:15:22Z","timestamp":1766556922853,"version":"3.48.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Physiol Biochem"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1007\/s13105-025-01121-7","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T02:26:28Z","timestamp":1754879188000},"page":"1067-1076","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Elevated hydrostatic pressure dysregulates lipid metabolism of hepatocytes"],"prefix":"10.1007","volume":"81","author":[{"given":"Zisheng","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weili","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao-Sheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,8,11]]},"reference":[{"key":"1121_CR1","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.tibtech.2007.01.005","volume":"25","author":"GY Lee","year":"2007","unstructured":"Lee GY, Lim CT (2007) Biomechanics approaches to studying human diseases. Trends Biotechnol 25:111\u2013118. https:\/\/doi.org\/10.1016\/j.tibtech.2007.01.005","journal-title":"Trends Biotechnol"},{"key":"1121_CR2","doi-asserted-by":"publisher","first-page":"1642","DOI":"10.1016\/j.jhep.2022.08.028","volume":"77","author":"EK Mitten","year":"2022","unstructured":"Mitten EK, Baffy G (2022) Mechanotransduction in the pathogenesis of non-alcoholic fatty liver disease. J Hepatol 77:1642\u20131656. https:\/\/doi.org\/10.1016\/j.jhep.2022.08.028","journal-title":"J Hepatol"},{"key":"1121_CR3","doi-asserted-by":"publisher","first-page":"3212","DOI":"10.1016\/j.celrep.2019.10.128","volume":"29","author":"P Sun","year":"2019","unstructured":"Sun P et al (2019) Maintenance of primary hepatocyte functions in vitro by inhibiting mechanical Tension-Induced YAP activation. Cell Rep 29:3212\u20133222. https:\/\/doi.org\/10.1016\/j.celrep.2019.10.128. e3214","journal-title":"Cell Rep"},{"key":"1121_CR4","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1111\/j.1439-0396.2007.00752.x","volume":"92","author":"P Nguyen","year":"2008","unstructured":"Nguyen P et al (2008) Liver lipid metabolism. J Anim Physiol Anim Nutr (Berl) 92:272\u2013283. https:\/\/doi.org\/10.1111\/j.1439-0396.2007.00752.x","journal-title":"J Anim Physiol Anim Nutr (Berl)"},{"key":"1121_CR5","doi-asserted-by":"publisher","first-page":"101115","DOI":"10.1016\/j.molmet.2020.101115","volume":"50","author":"DG Mashek","year":"2021","unstructured":"Mashek DG (2021) Hepatic lipid droplets: A balancing act between energy storage and metabolic dysfunction in NAFLD. Mol Metab 50:101115. https:\/\/doi.org\/10.1016\/j.molmet.2020.101115","journal-title":"Mol Metab"},{"key":"1121_CR6","doi-asserted-by":"publisher","first-page":"C889","DOI":"10.1152\/ajpcell.00472.2019","volume":"318","author":"L Burton","year":"2020","unstructured":"Burton L et al (2020) Hydrostatic pressure regulates CYP1A2 expression in human hepatocytes via a mechanosensitive Aryl hydrocarbon receptor-dependent pathway. Am J Physiol Cell Physiol 318:C889\u2013C902. https:\/\/doi.org\/10.1152\/ajpcell.00472.2019","journal-title":"Am J Physiol Cell Physiol"},{"key":"1121_CR7","doi-asserted-by":"publisher","first-page":"9944","DOI":"10.1073\/pnas.0914547107","volume":"107","author":"Z Liu","year":"2010","unstructured":"Liu Z et al (2010) Mechanical tugging force regulates the size of cell-cell junctions. Proc Natl Acad Sci U S A 107:9944\u20139949. https:\/\/doi.org\/10.1073\/pnas.0914547107","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1121_CR8","doi-asserted-by":"publisher","unstructured":"DeWane G, Salvi AM, DeMali KA (2021) Fueling the cytoskeleton - links between cell metabolism and actin remodeling. J Cell Sci 134. https:\/\/doi.org\/10.1242\/jcs.248385","DOI":"10.1242\/jcs.248385"},{"key":"1121_CR9","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1038\/s41586-020-1998-1","volume":"578","author":"JS Park","year":"2020","unstructured":"Park JS et al (2020) Mechanical regulation of Glycolysis via cytoskeleton architecture. Nature 578:621\u2013626. https:\/\/doi.org\/10.1038\/s41586-020-1998-1","journal-title":"Nature"},{"key":"1121_CR10","doi-asserted-by":"publisher","first-page":"eaav9960","DOI":"10.1126\/sciadv.aav9960","volume":"5","author":"G Nagamatsu","year":"2019","unstructured":"Nagamatsu G, Shimamoto S, Hamazaki N, Nishimura Y, Hayashi K (2019) Mechanical stress accompanied with nuclear rotation is involved in the dormant state of mouse oocytes. Sci Adv 5:eaav9960. https:\/\/doi.org\/10.1126\/sciadv.aav9960","journal-title":"Sci Adv"},{"key":"1121_CR11","doi-asserted-by":"publisher","first-page":"8625","DOI":"10.1073\/pnas.95.15.8625","volume":"95","author":"D Hirsch","year":"1998","unstructured":"Hirsch D, Stahl A, Lodish HF (1998) A family of fatty acid transporters conserved from Mycobacterium to man. Proc Natl Acad Sci U S A 95:8625\u20138629. https:\/\/doi.org\/10.1073\/pnas.95.15.8625","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1121_CR12","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1172\/JCI34275","volume":"118","author":"C Postic","year":"2008","unstructured":"Postic C, Girard J (2008) Contribution of de Novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice. J Clin Invest 118:829\u2013838. https:\/\/doi.org\/10.1172\/JCI34275","journal-title":"J Clin Invest"},{"key":"1121_CR13","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1016\/j.mam.2004.06.004","volume":"25","author":"JP Bonnefont","year":"2004","unstructured":"Bonnefont JP et al (2004) Carnitine palmitoyltransferases 1 and 2: biochemical, molecular and medical aspects. Mol Aspects Med 25:495\u2013520. https:\/\/doi.org\/10.1016\/j.mam.2004.06.004","journal-title":"Mol Aspects Med"},{"key":"1121_CR14","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/S0022-2275(20)32059-9","volume":"41","author":"K Tsukamoto","year":"2000","unstructured":"Tsukamoto K, Maugeais C, Glick JM, Rader DJ (2000) Markedly increased secretion of VLDL triglycerides induced by gene transfer of Apolipoprotein E isoforms in apoE-deficient mice. J Lipid Res 41:253\u2013259","journal-title":"J Lipid Res"},{"key":"1121_CR15","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1080\/10408369891234246","volume":"35","author":"TM Mason","year":"1998","unstructured":"Mason TM (1998) The role of factors that regulate the synthesis and secretion of very-low-density lipoprotein by hepatocytes. Crit Rev Clin Lab Sci 35:461\u2013487. https:\/\/doi.org\/10.1080\/10408369891234246","journal-title":"Crit Rev Clin Lab Sci"},{"key":"1121_CR16","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1002\/hep.28906","volume":"65","author":"G Garcia-Tsao","year":"2017","unstructured":"Garcia-Tsao G, Abraldes JG, Berzigotti A, Bosch J (2017) Portal hypertensive bleeding in cirrhosis: risk stratification, diagnosis, and management: 2016 practice guidance by the American association for the study of liver diseases. Hepatology 65:310\u2013335. https:\/\/doi.org\/10.1002\/hep.28906","journal-title":"Hepatology"},{"key":"1121_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/cphy.c170012","volume":"8","author":"M Alves-Bezerra","year":"2017","unstructured":"Alves-Bezerra M, Cohen DE (2017) Triglyceride metabolism in the liver. Compr Physiol 8:1\u20138. https:\/\/doi.org\/10.1002\/cphy.c170012","journal-title":"Compr Physiol"},{"key":"1121_CR18","doi-asserted-by":"publisher","first-page":"5269","DOI":"10.1002\/cphy.c230005","volume":"14","author":"JD Tranter","year":"2023","unstructured":"Tranter JD, Kumar A, Nair VK, Sah R (2023) Mechanosensing in metabolism. Compr Physiol 14:5269\u20135290. https:\/\/doi.org\/10.1002\/cphy.c230005","journal-title":"Compr Physiol"},{"key":"1121_CR19","doi-asserted-by":"publisher","first-page":"102219","DOI":"10.1016\/j.ceb.2023.102219","volume":"84","author":"LW Dawson","year":"2023","unstructured":"Dawson LW, Cronin NM, DeMali KA (2023) Mechanotransduction: forcing a change in metabolism. Curr Opin Cell Biol 84:102219. https:\/\/doi.org\/10.1016\/j.ceb.2023.102219","journal-title":"Curr Opin Cell Biol"},{"key":"1121_CR20","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1055\/s-0039-3399502","volume":"40","author":"N Kang","year":"2020","unstructured":"Kang N (2020) Mechanotransduction in liver diseases. Semin Liver Dis 40:84\u201390. https:\/\/doi.org\/10.1055\/s-0039-3399502","journal-title":"Semin Liver Dis"},{"key":"1121_CR21","doi-asserted-by":"crossref","unstructured":"Lautt WW (2009) Hepatic circulation: physiology and pathophysiology. Morgan & Claypool Life Sciences","DOI":"10.4199\/C00004ED1V01Y200910ISP001"},{"key":"1121_CR22","doi-asserted-by":"publisher","first-page":"R722","DOI":"10.1152\/ajpregu.00178.2019","volume":"318","author":"RM Dongaonkar","year":"2020","unstructured":"Dongaonkar RM et al (2020) Adaptation of the hepatic transudation barrier to sinusoidal hypertension. Am J Physiol Regul Integr Comp Physiol 318:R722\u2013R729. https:\/\/doi.org\/10.1152\/ajpregu.00178.2019","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"1121_CR23","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1002\/cld.1031","volume":"17","author":"T Bochnakova","year":"2021","unstructured":"Bochnakova T (2021) Hepatic venous pressure gradient. Clin Liver Dis (Hoboken) 17:144\u2013148. https:\/\/doi.org\/10.1002\/cld.1031","journal-title":"Clin Liver Dis (Hoboken)"},{"key":"1121_CR24","doi-asserted-by":"publisher","first-page":"100905","DOI":"10.1016\/j.jhepr.2023.100905","volume":"5","author":"W Li","year":"2023","unstructured":"Li W et al (2023) Direct mechanical exposure initiates hepatocyte proliferation. JHEP Rep 5:100905. https:\/\/doi.org\/10.1016\/j.jhepr.2023.100905","journal-title":"JHEP Rep"},{"key":"1121_CR25","doi-asserted-by":"publisher","first-page":"1522","DOI":"10.1016\/s0264-410x(99)00438-7","volume":"18","author":"JV Rogers","year":"2000","unstructured":"Rogers JV, Hull BE, Fink PS, Chiou HC, Bigley NJ (2000) Murine response to DNA encoding herpes simplex virus type-1 glycoprotein D targeted to the liver. Vaccine 18:1522\u20131530. https:\/\/doi.org\/10.1016\/s0264-410x(99)00438-7","journal-title":"Vaccine"},{"key":"1121_CR26","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.1097\/MEG.0b013e32833f14a1","volume":"22","author":"S Francque","year":"2010","unstructured":"Francque S et al (2010) Noncirrhotic human nonalcoholic fatty liver disease induces portal hypertension in relation to the histological degree of steatosis. Eur J Gastroenterol Hepatol 22:1449\u20131457. https:\/\/doi.org\/10.1097\/MEG.0b013e32833f14a1","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"1121_CR27","doi-asserted-by":"publisher","first-page":"2576","DOI":"10.1111\/febs.16568","volume":"290","author":"X Sun","year":"2023","unstructured":"Sun X, Alushin GM (2023) Cellular force-sensing through actin filaments. FEBS J 290:2576\u20132589. https:\/\/doi.org\/10.1111\/febs.16568","journal-title":"FEBS J"},{"key":"1121_CR28","doi-asserted-by":"publisher","first-page":"1394","DOI":"10.1136\/gut.2010.222844","volume":"60","author":"ME Miquilena-Colina","year":"2011","unstructured":"Miquilena-Colina ME et al (2011) Hepatic fatty acid translocase CD36 upregulation is associated with insulin resistance, hyperinsulinaemia and increased steatosis in non-alcoholic steatohepatitis and chronic hepatitis C. Gut 60:1394\u20131402. https:\/\/doi.org\/10.1136\/gut.2010.222844","journal-title":"Gut"},{"key":"1121_CR29","doi-asserted-by":"publisher","first-page":"2859","DOI":"10.1016\/j.celrep.2016.02.071","volume":"14","author":"HS Wong","year":"2016","unstructured":"Wong HS et al (2016) Chemokine signaling enhances CD36 responsiveness toward oxidized Low-Density lipoproteins and accelerates foam cell formation. Cell Rep 14:2859\u20132871. https:\/\/doi.org\/10.1016\/j.celrep.2016.02.071","journal-title":"Cell Rep"},{"key":"1121_CR30","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/j.cell.2011.06.049","volume":"146","author":"K Jaqaman","year":"2011","unstructured":"Jaqaman K et al (2011) Cytoskeletal control of CD36 diffusion promotes its receptor and signaling function. Cell 146:593\u2013606. https:\/\/doi.org\/10.1016\/j.cell.2011.06.049","journal-title":"Cell"},{"key":"1121_CR31","doi-asserted-by":"publisher","first-page":"4029","DOI":"10.1038\/s41467-023-39752-3","volume":"14","author":"VS Peche","year":"2023","unstructured":"Peche VS et al (2023) Endothelial cell CD36 regulates membrane ceramide formation, exosome fatty acid transfer and Circulating fatty acid levels. Nat Commun 14:4029. https:\/\/doi.org\/10.1038\/s41467-023-39752-3","journal-title":"Nat Commun"},{"key":"1121_CR32","doi-asserted-by":"publisher","first-page":"26695","DOI":"10.1074\/jbc.M109.033480","volume":"284","author":"BR Mwaikambo","year":"2009","unstructured":"Mwaikambo BR, Yang C, Chemtob S, Hardy P (2009) Hypoxia up-regulates CD36 expression and function via hypoxia-inducible factor-1- and phosphatidylinositol 3-kinase-dependent mechanisms. J Biol Chem 284:26695\u201326707. https:\/\/doi.org\/10.1074\/jbc.M109.033480","journal-title":"J Biol Chem"},{"key":"1121_CR33","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.1038\/sj.bjc.6605007","volume":"100","author":"T Mashima","year":"2009","unstructured":"Mashima T, Seimiya H, Tsuruo T (2009) De Novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy. Br J Cancer 100:1369\u20131372. https:\/\/doi.org\/10.1038\/sj.bjc.6605007","journal-title":"Br J Cancer"},{"key":"1121_CR34","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1038\/s41556-018-0270-5","volume":"21","author":"P Romani","year":"2019","unstructured":"Romani P et al (2019) Extracellular matrix mechanical cues regulate lipid metabolism through Lipin-1 and SREBP. Nat Cell Biol 21:338\u2013347. https:\/\/doi.org\/10.1038\/s41556-018-0270-5","journal-title":"Nat Cell Biol"},{"key":"1121_CR35","doi-asserted-by":"publisher","first-page":"3313","DOI":"10.1007\/s00018-018-2860-6","volume":"75","author":"DH Ipsen","year":"2018","unstructured":"Ipsen DH, Lykkesfeldt J, Tveden-Nyborg P (2018) Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease. Cell Mol Life Sci 75:3313\u20133327. https:\/\/doi.org\/10.1007\/s00018-018-2860-6","journal-title":"Cell Mol Life Sci"},{"key":"1121_CR36","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1136\/gutjnl-2015-310798","volume":"65","author":"A Montagner","year":"2016","unstructured":"Montagner A et al (2016) Liver PPARalpha is crucial for whole-body fatty acid homeostasis and is protective against NAFLD. Gut 65:1202\u20131214. https:\/\/doi.org\/10.1136\/gutjnl-2015-310798","journal-title":"Gut"}],"container-title":["Journal of Physiology and Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13105-025-01121-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13105-025-01121-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13105-025-01121-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T05:45:07Z","timestamp":1766555107000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13105-025-01121-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,11]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["1121"],"URL":"https:\/\/doi.org\/10.1007\/s13105-025-01121-7","relation":{},"ISSN":["1138-7548","1877-8755"],"issn-type":[{"type":"print","value":"1138-7548"},{"type":"electronic","value":"1877-8755"}],"subject":[],"published":{"date-parts":[[2025,8,11]]},"assertion":[{"value":"20 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}