{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T03:20:04Z","timestamp":1772248804248,"version":"3.50.1"},"reference-count":119,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T00:00:00Z","timestamp":1772236800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T00:00:00Z","timestamp":1772236800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Noncommunicable Chronic Diseases-National Science and Technology Major Project","award":["No. 2024ZD0530700"],"award-info":[{"award-number":["No. 2024ZD0530700"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Physiol Biochem"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s13105-026-01161-7","type":"journal-article","created":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T02:51:42Z","timestamp":1772247102000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Metabolic syndrome necroptosis: disease implications and therapeutic targeting"],"prefix":"10.1007","volume":"82","author":[{"given":"Jiaenli","family":"Bolati","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahequeli","family":"Gemingnuer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yueqi","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donghua","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunmiao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,2,28]]},"reference":[{"key":"1161_CR1","doi-asserted-by":"publisher","first-page":"117196","DOI":"10.1016\/j.biopha.2024.117196","volume":"178","author":"T Zhu","year":"2024","unstructured":"Zhu T, Wu BW (2024) Recognition of necroptosis: from molecular mechanisms to detection methods. Biomed Pharmacother 178:117196. https:\/\/doi.org\/10.1016\/j.biopha.2024.117196","journal-title":"Biomed Pharmacother"},{"issue":"2","key":"1161_CR2","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1038\/s44321-023-00011-z","volume":"16","author":"X Wu","year":"2024","unstructured":"Wu X, Nagy LE, Gautheron J (2024) Mediators of necroptosis: from cell death to metabolic regulation. EMBO Mol Med 16(2):219\u2013237. https:\/\/doi.org\/10.1038\/s44321-023-00011-z","journal-title":"EMBO Mol Med"},{"issue":"3","key":"1161_CR3","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/j.immuni.2024.02.011","volume":"57","author":"KE Lawlor","year":"2024","unstructured":"Lawlor KE, Murphy JM, Vince JE (2024) Gasdermin and MLKL necrotic cell death effectors: signaling and diseases. Immunity 57(3):429\u2013445. https:\/\/doi.org\/10.1016\/j.immuni.2024.02.011","journal-title":"Immunity"},{"issue":"1","key":"1161_CR4","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1038\/s41572-024-00563-5","volume":"10","author":"IJ Neeland","year":"2024","unstructured":"Neeland IJ, Lim S, Tchernof A, Gastaldelli A, Rangaswami J, Ndumele CE, Powell-Wiley TM, Despr\u00e9s JP (2024) Metabolic syndrome. Nat Reviews Disease Primers 10(1):77. https:\/\/doi.org\/10.1038\/s41572-024-00563-5","journal-title":"Nat Reviews Disease Primers"},{"issue":"1","key":"1161_CR5","first-page":"20","volume":"1","author":"AD Ibrahim","year":"2024","unstructured":"Ibrahim AD (2024) Metabolic disorders worldwide: Prevalence, contributing Factors, and management approaches. Int J Sport Phys Educ Public Health 1(1):20\u201329","journal-title":"Int J Sport Phys Educ Public Health"},{"key":"1161_CR6","doi-asserted-by":"publisher","unstructured":"Singh NK, Dubey P, Singh S, Singh R (2026) Pathophysiology mechanism in therapeutics of metabolic syndrome. Nanotheranostics Metabolic Syndrome: Transforming Diagnosis Ther 33\u201384. https:\/\/doi.org\/10.1007\/978-981-95-3746-4_2","DOI":"10.1007\/978-981-95-3746-4_2"},{"key":"1161_CR7","doi-asserted-by":"publisher","first-page":"1449696","DOI":"10.3389\/fonc.2024.1449696","volume":"14","author":"Y Ge","year":"2024","unstructured":"Ge Y et al (2024) Interactions between tumor-asso Ciated macrophages and regulated cell death: therapeutic implications in immuno-oncology. Front Oncol 14:1449696. https:\/\/doi.org\/10.3389\/fonc.2024.1449696","journal-title":"Front Oncol"},{"issue":"1","key":"1161_CR8","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1038\/s41420-024-01957-w","volume":"10","author":"Y Zhou","year":"2024","unstructured":"Zhou Y et al (2024) RIPK3 signaling and its role in regulated cell death and diseases. Cell Death Discovery 10(1):200. https:\/\/doi.org\/10.1038\/s41420-024-01957-w","journal-title":"Cell Death Discovery"},{"key":"1161_CR9","unstructured":"Veli \u00d6 (2025) The regulation of Tnf signaling in Metabolism-Related diseases. Universit\u00e4t zu K\u00f6ln"},{"key":"1161_CR10","doi-asserted-by":"publisher","first-page":"1611932","DOI":"10.3389\/fimmu.2025.1611932","volume":"16","author":"J Luo","year":"2025","unstructured":"Luo J et al (2025) Oxidative stress and inflammation: roles in osteoporosis. Front Immunol 16:1611932. https:\/\/doi.org\/10.3389\/fimmu.2025.1611932","journal-title":"Front Immunol"},{"issue":"4","key":"1161_CR11","doi-asserted-by":"publisher","first-page":"273","DOI":"10.26502\/aimr.0184","volume":"7","author":"R Patial","year":"2025","unstructured":"Patial R et al (2025) Etiology, pathophysiology, and treatment strategies in the prevention and management of metabolic syndrome. Archives Intern Med Res 7(4):273\u2013283. https:\/\/doi.org\/10.26502\/aimr.0184","journal-title":"Archives Intern Med Res"},{"issue":"5","key":"1161_CR12","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1038\/s41580-023-00689-6","volume":"25","author":"J Yuan","year":"2024","unstructured":"Yuan J, Ofengeim D (2024) A guide to cell death pathways. Nat Rev Mol Cell Biol 25(5):379\u2013395. https:\/\/doi.org\/10.1038\/s41580-023-00689-6","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"3","key":"1161_CR13","doi-asserted-by":"publisher","first-page":"226","DOI":"10.3390\/obesities4030020","volume":"4","author":"FS Thomaz","year":"2024","unstructured":"Thomaz FS, John OD, Sinha P et al (2024) The metabolic syndrome: an overview and proposed mechanisms. Obesitie 4(3):226\u2013255. https:\/\/doi.org\/10.3390\/obesities4030020","journal-title":"Obesitie"},{"key":"1161_CR14","unstructured":"Knapp AR (2024) Characterization of the Hyperglycemic Shift From Apoptosis to Necroptosis in Monocyte-Derived Macrophages"},{"issue":"4","key":"1161_CR15","doi-asserted-by":"publisher","first-page":"549","DOI":"10.3390\/biom15040549","volume":"15","author":"H Xiao","year":"2025","unstructured":"Xiao H et al (2025) The role of Post-Translational modifications in necroptosis. Biomolecules 15(4):549. https:\/\/doi.org\/10.3390\/biom15040549","journal-title":"Biomolecules"},{"issue":"1","key":"1161_CR16","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1038\/s41418-023-01237-7","volume":"31","author":"S Liu","year":"2024","unstructured":"Liu S et al (2024) MLKL polymerization-induced lysosomal membrane permeabilization promotes necroptosis. Cell Death Differ 31(1):40\u201352. https:\/\/doi.org\/10.1038\/s41418-023-01237-7","journal-title":"Cell Death Differ"},{"key":"1161_CR17","doi-asserted-by":"publisher","DOI":"10.22541\/au.173372824.45261156\/v1","author":"R Chen","year":"2024","unstructured":"Chen R et al (2024) The DAMP theory: Concepts, Evidence, and implications. Authorea. https:\/\/doi.org\/10.22541\/au.173372824.45261156\/v1","journal-title":"Authorea"},{"issue":"20","key":"1161_CR18","doi-asserted-by":"publisher","first-page":"3874","DOI":"10.1016\/j.molcel.2025.09.007","volume":"85","author":"R Chen","year":"2025","unstructured":"Chen R, Zou J, Liu J et al (2025) DAMPs in the immunogenicity of cell death. Mol Cell 85(20):3874\u20133889. https:\/\/doi.org\/10.1016\/j.molcel.2025.09.007","journal-title":"Mol Cell"},{"issue":"19","key":"1161_CR19","doi-asserted-by":"publisher","first-page":"10760","DOI":"10.3390\/ijms251910760","volume":"25","author":"Z Zhang","year":"2024","unstructured":"Zhang Z, Zhang F, Xie W et al (2024) Induced necroptosis and its role in cancer immunotherapy. Int J Mol Sci 25(19):10760. https:\/\/doi.org\/10.3390\/ijms251910760","journal-title":"Int J Mol Sci"},{"issue":"6","key":"1161_CR20","doi-asserted-by":"publisher","first-page":"e13724","DOI":"10.1111\/obr.13724","volume":"25","author":"S Xu","year":"2024","unstructured":"Xu S, Lu F, Gao J et al (2024) Inflammation-mediated metabolic regulation in adipose tissue. Obes Rev 25(6):e13724. https:\/\/doi.org\/10.1111\/obr.13724","journal-title":"Obes Rev"},{"key":"1161_CR21","doi-asserted-by":"publisher","unstructured":"Chakrabarti SS, Saso L, Bala S et al (2024) Role of oxidative stress in the pathogenesis of metabolic syndrome. Metabolic Syndrome 143\u2013156. https:\/\/doi.org\/10.1016\/B978-0-323-85732-1.00021-9","DOI":"10.1016\/B978-0-323-85732-1.00021-9"},{"issue":"12","key":"1161_CR22","doi-asserted-by":"publisher","first-page":"104439","DOI":"10.1016\/j.psj.2024.104439","volume":"103","author":"X Chen","year":"2024","unstructured":"Chen X, Wang Y, Zhang M et al (2024) Selenomethionine alleviates kidney necroptosis and inflammation by restoring lipopolysaccharide-mediated mitochondrial dynamics imbalance via the TLR4\/RIPK3\/DRP1 signaling pathway in laying hens. Poult Sci 103(12):104439. https:\/\/doi.org\/10.1016\/j.psj.2024.104439","journal-title":"Poult Sci"},{"key":"1161_CR23","doi-asserted-by":"publisher","first-page":"1512968","DOI":"10.3389\/fphar.2025.1512968","volume":"16","author":"Wang","year":"2025","unstructured":"Wang, Yang et al (2025) MLKL as an emerging machinery for modulating organelle dynamics: regulatory mechanisms, pathophysiological significance, and targeted therapeutics. Front Pharmacol 16:1512968. https:\/\/doi.org\/10.3389\/fphar.2025.1512968","journal-title":"Front Pharmacol"},{"issue":"1","key":"1161_CR24","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/s00011-025-01994-w","volume":"74","author":"Iba","year":"2025","unstructured":"Iba, Toshiaki et al (2025) Mitochondrial dysfunction is a major cause of thromboinflammation and inflammatory cell death in critical illnesses. Inflamm Res 74(1):17. https:\/\/doi.org\/10.1007\/s00011-025-01994-w","journal-title":"Inflamm Res"},{"issue":"1","key":"1161_CR25","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/s41420-025-02328-9","volume":"11","author":"Eskander","year":"2025","unstructured":"Eskander, Georgette et al (2025) Insights on the crosstalk among different cell death mechanisms. Cell Death Discovery 11(1):56. https:\/\/doi.org\/10.1038\/s41420-025-02328-9","journal-title":"Cell Death Discovery"},{"key":"1161_CR26","doi-asserted-by":"publisher","unstructured":"Wu, Wang et al (2026) Pyroptosis: mechanism and therapeutic strategies with intervertebral disc degeneration. Experimental Mol Medicin 1\u201311. https:\/\/doi.org\/10.1038\/s12276-025-01630-x","DOI":"10.1038\/s12276-025-01630-x"},{"issue":"11","key":"1161_CR27","doi-asserted-by":"publisher","first-page":"2635","DOI":"10.1007\/s10495-025-02170-5","volume":"30","author":"S Li","year":"2025","unstructured":"Li S, Shu Y, Yang S et al (2025) Oxidative stress and ferroptosis in diabetic cardiomyopathy: mechanistic interplay and therapeutic implications. Apoptosis 30(11):2635\u20132653. https:\/\/doi.org\/10.1007\/s10495-025-02170-5","journal-title":"Apoptosis"},{"issue":"1","key":"1161_CR28","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1007\/s10495-024-02055-z","volume":"30","author":"Z Liu","year":"2025","unstructured":"Liu Z, Wang S, Wang W et al (2025) Necroptosis in obesity: a complex cell death event. Apoptosis 30(1):466\u2013487. https:\/\/doi.org\/10.1007\/s10495-024-02055-z","journal-title":"Apoptosis"},{"issue":"2","key":"1161_CR29","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.tem.2024.07.004","volume":"36","author":"Han Sang","year":"2025","unstructured":"Han Sang, Mun et al (2025) How obesity affects adipocyte turnover. Trends Endocrinol Metabolism 36(2):147\u2013160. https:\/\/doi.org\/10.1016\/j.tem.2024.07.004","journal-title":"Trends Endocrinol Metabolism"},{"issue":"8","key":"1161_CR30","doi-asserted-by":"publisher","first-page":"NP585","DOI":"10.1093\/asj\/sjae108","volume":"44","author":"X Liu","year":"2024","unstructured":"Liu X, Yao Y, Zhu Y et al (2024) Inhibition of adipocyte necroptosis alleviates fat necrosis and fibrosis after grafting in a murine model. Aesthetic Surg J 44(8):NP585\u2013NP605. https:\/\/doi.org\/10.1093\/asj\/sjae108","journal-title":"Aesthetic Surg J"},{"key":"1161_CR31","doi-asserted-by":"publisher","first-page":"102039","DOI":"10.1016\/j.molmet.2024.102039","volume":"90","author":"S Lee","year":"2024","unstructured":"Lee S, Cho YK, Kim H et al (2024) miR-10a regulates cell death and inflammation in adipose tissue of male mice with diet-induced obesity. Mol Metabolism 90:102039. https:\/\/doi.org\/10.1016\/j.molmet.2024.102039","journal-title":"Mol Metabolism"},{"issue":"38","key":"1161_CR32","doi-asserted-by":"publisher","first-page":"eadw2539","DOI":"10.1126\/sciadv.adw2539","volume":"11","author":"Hildebrandt","year":"2025","unstructured":"Hildebrandt, Ximena et al (2025) Linear ubiquitination prevents lipodystrophy and obesity-associated metabolic syndrome. Sci Adv 11(38):eadw2539. https:\/\/doi.org\/10.1126\/sciadv.adw2539","journal-title":"Sci Adv"},{"issue":"5","key":"1161_CR33","doi-asserted-by":"publisher","first-page":"2813","DOI":"10.3390\/ijms25052813","volume":"25","author":"P Ohene-Marfo","year":"2024","unstructured":"Ohene-Marfo P, Nguyen HVM, Mohammed S et al (2024) Non-necroptotic roles of MLKL in diet-induced obesity, liver pathology, and insulin sensitivity: insights from a high-fat, high-fructose, high-cholesterol diet mouse model. Int J Mol Sci 25(5):2813. https:\/\/doi.org\/10.3390\/ijms25052813","journal-title":"Int J Mol Sci"},{"issue":"5","key":"1161_CR34","doi-asserted-by":"publisher","first-page":"1940","DOI":"10.3390\/ijms26051940","volume":"26","author":"S Promsan","year":"2025","unstructured":"Promsan S, Pengrattanachot N, Phengpol N et al (2025) Agomelatine mitigates kidney damage in obese Insulin-Resistant rats by inhibiting inflammation and necroptosis via the TNF-\u03b1\/NF-\u0138B\/p-RIPK3 pathway. Int J Mol Sci 26(5):1940. https:\/\/doi.org\/10.3390\/ijms26051940","journal-title":"Int J Mol Sci"},{"issue":"1","key":"1161_CR35","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1038\/s41419-025-08004-1","volume":"16","author":"J Tokgozoglu","year":"2025","unstructured":"Tokgozoglu J, Pistorio V, Minini M et al (2025) Adipocyte-specific Mlkl knockout mitigates obesity-induced metabolic dysfunction by enhancing mitochondrial functions. Cell Death Dis 16(1):683. https:\/\/doi.org\/10.1038\/s41419-025-08004-1","journal-title":"Cell Death Dis"},{"issue":"1","key":"1161_CR36","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1038\/s41420-025-02558-x","volume":"11","author":"J Xi","year":"2025","unstructured":"Xi J, Lei S, Chen J et al (2025) Killing hepatocellular carcinoma in the NAFLD\/NASH stage: a comprehensive perspective on targeting regulated cell death. Cell Death Discovery 11(1):281. https:\/\/doi.org\/10.1038\/s41420-025-02558-x","journal-title":"Cell Death Discovery"},{"issue":"14","key":"1161_CR37","doi-asserted-by":"publisher","first-page":"1968","DOI":"10.3748\/wjg.v30.i14.1968","volume":"30","author":"HJ Sun","year":"2024","unstructured":"Sun HJ, Jiao B, Wang Y et al (2024) Necroptosis contributes to non-alcoholic fatty liver disease pathoetiology with promising diagnostic and therapeutic functions. World J Gastroenterol 30(14):1968\u20131981. https:\/\/doi.org\/10.3748\/wjg.v30.i14.1968","journal-title":"World J Gastroenterol"},{"key":"1161_CR38","doi-asserted-by":"publisher","unstructured":"Tayir M, Wang YW, Chu T et al (2025) The function of necroptosis in liver cancer. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 167828. https:\/\/doi.org\/10.1016\/j.bbadis.2025.167828","DOI":"10.1016\/j.bbadis.2025.167828"},{"issue":"9","key":"1161_CR39","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1038\/s41419-023-06161-9","volume":"14","author":"MP Scavo","year":"2023","unstructured":"Scavo MP et al (2023) The oleic\/palmitic acid imbalance in exosomes isolated from NAFLD patients induces necroptosis of liver cells via the elongase-6\/RIP-1 pathway. Cell Death Dis 14(9):635. https:\/\/doi.org\/10.1038\/s41419-023-06161-9","journal-title":"Cell Death Dis"},{"key":"1161_CR40","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.freeradbiomed.2024.03.014","volume":"217","author":"T Wang","year":"2024","unstructured":"Wang T, Wang D, Kuang G et al (2024) Derlin-1 promotes diet-induced non-alcoholic fatty liver disease via increasing RIPK3-mediated necroptosis. Free Radic Biol Med 217:29\u201347. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2024.03.014","journal-title":"Free Radic Biol Med"},{"key":"1161_CR41","doi-asserted-by":"publisher","first-page":"101865","DOI":"10.1016\/j.molmet.2023.101865","volume":"80","author":"JB Zhang","year":"2024","unstructured":"Zhang JB, Zhang QR, Jin Q et al (2024) Sestrin2 maintains hepatic immune homeostasis and redox balance partially via inhibiting RIPK3-mediated necroptosis in metabolic dysfunction-associated steatohepatitis. Mol Metabolism 80:101865. https:\/\/doi.org\/10.1016\/j.molmet.2023.101865","journal-title":"Mol Metabolism"},{"issue":"1","key":"1161_CR42","doi-asserted-by":"publisher","first-page":"2531650","DOI":"10.1080\/13510002.2025.2531650","volume":"30","author":"C Wu","year":"2025","unstructured":"Wu C, Zhang W, Liu W et al (2025) Cystathionine \u03b3-lyase downregulation promotes liver injury and necroptosis through reprogramming of methionine cycle. Redox Rep 30(1):2531650. https:\/\/doi.org\/10.1080\/13510002.2025.2531650","journal-title":"Redox Rep"},{"issue":"7","key":"1161_CR43","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1038\/s41419-024-06910-4","volume":"15","author":"M Gu","year":"2024","unstructured":"Gu M, Zhang Y, Lin Z et al (2024) Decrease in UCP1 by sustained high lipid promotes NK cell necroptosis to exacerbate nonalcoholic liver fibrosis. Cell Death Dis 15(7):518. https:\/\/doi.org\/10.1038\/s41419-024-06910-4","journal-title":"Cell Death Dis"},{"issue":"1","key":"1161_CR44","doi-asserted-by":"publisher","first-page":"e4694","DOI":"10.1002\/fsn3.4694","volume":"13","author":"Z Li","year":"2025","unstructured":"Li Z, Li J, He S et al (2025) Ellagic acid modulates Necroptosis, Autophagy, Inflammations, and stress to ameliorate nonalcoholic liver fatty disease in a rat model. Food Sci Nutr 13(1):e4694. https:\/\/doi.org\/10.1002\/fsn3.4694","journal-title":"Food Sci Nutr"},{"issue":"5","key":"1161_CR45","doi-asserted-by":"publisher","first-page":"4591","DOI":"10.18632\/aging.205616","volume":"16","author":"J Li","year":"2024","unstructured":"Li J, Ni Y, Zhang Y et al (2024) GBA3 promotes fatty acid oxidation and alleviates non-alcoholic fatty liver by increasing CPT2 transcription. Aging 16(5):4591. https:\/\/doi.org\/10.18632\/aging.205616","journal-title":"Aging"},{"key":"1161_CR46","doi-asserted-by":"publisher","first-page":"116774","DOI":"10.1016\/j.taap.2023.116774","volume":"482","author":"AE Amer","year":"2024","unstructured":"Amer AE, Ghoneim HA, Abdelaziz RR et al (2024) Saroglitazar mitigated NASH-associated hepatic injury in dexamethasone-treated rats via modulating autophagy, apoptosis, and necroptosis. Toxicol Appl Pharmcol 482:116774. https:\/\/doi.org\/10.1016\/j.taap.2023.116774","journal-title":"Toxicol Appl Pharmcol"},{"key":"1161_CR47","doi-asserted-by":"publisher","first-page":"117909","DOI":"10.1016\/j.jep.2024.117909","volume":"326","author":"B Zou","year":"2024","unstructured":"Zou B, Zhang S, Li F et al (2024) Gancao Decoction attenuates hepatic necroptosis via activating caspase 8 in cholestatic liver injury. J Ethnopharmacol 326:117909. https:\/\/doi.org\/10.1016\/j.jep.2024.117909","journal-title":"J Ethnopharmacol"},{"key":"1161_CR48","doi-asserted-by":"publisher","first-page":"118253","DOI":"10.1016\/j.jep.2024.118253","volume":"330","author":"S Xian","year":"2024","unstructured":"Xian S, Yang Y, Nan N et al (2024) Inhibition of mitochondrial ROS-mediated necroptosis by dendrobium nobile Lindl. Alkaloids in carbon tetrachloride induced acute liver injury. J Ethnopharmacol 330:118253. https:\/\/doi.org\/10.1016\/j.jep.2024.118253","journal-title":"J Ethnopharmacol"},{"issue":"1","key":"1161_CR49","doi-asserted-by":"publisher","first-page":"17546","DOI":"10.1038\/s41598-025-02483-0","volume":"15","author":"HRM Rashdan","year":"2025","unstructured":"Rashdan HRM, Hassan S, Maher S et al (2025) Towards novel liver injury therapies based on design, synthesis and therapeutic efficacy of novel sulfone bis-compound on liver necrosis. Sci Rep 15(1):17546. https:\/\/doi.org\/10.1038\/s41598-025-02483-0","journal-title":"Sci Rep"},{"issue":"1","key":"1161_CR50","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1007\/s00018-024-05365-2","volume":"81","author":"X Li","year":"2024","unstructured":"Li X, Hong L, Ru MH et al (2024) S100A8\/A9-activated IFN\u03b3\u2009+\u2009NK cells trigger \u03b2-cell necroptosis in hepatitis B virus-associated liver cirrhosis. Cell Mol Life Sci 81(1):345. https:\/\/doi.org\/10.1007\/s00018-024-05365-2","journal-title":"Cell Mol Life Sci"},{"issue":"1","key":"1161_CR51","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1097\/CM9.0000000000003230","volume":"138","author":"X Chen","year":"2025","unstructured":"Chen X, Xie N, Feng L et al (2025) Oxidative stress in diabetes mellitus and its complications: from pathophysiology to therapeutic strategies. Chin Med J 138(1):15\u201327. https:\/\/doi.org\/10.1097\/CM9.0000000000003230","journal-title":"Chin Med J"},{"issue":"4","key":"1161_CR52","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1007\/s00109-024-02421-z","volume":"102","author":"H Pang","year":"2024","unstructured":"Pang H, Huang G, Xie Z et al (2024) The role of regulated necrosis in diabetes and its complications. J Mol Med 102(4):495\u2013505. https:\/\/doi.org\/10.1007\/s00109-024-02421-z","journal-title":"J Mol Med"},{"issue":"1","key":"1161_CR53","doi-asserted-by":"publisher","first-page":"9926462","DOI":"10.1155\/2023\/9926462","volume":"2023","author":"F Deng","year":"2023","unstructured":"Deng F, Wu W, Fan X et al (2023) Dulaglutide protects mice against diabetic sarcopenia-mediated muscle injury by inhibiting inflammation and regulating the differentiation of myoblasts. Int J Endocrinol 2023(1):9926462. https:\/\/doi.org\/10.1155\/2023\/9926462","journal-title":"Int J Endocrinol"},{"issue":"1","key":"1161_CR54","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1186\/s12902-025-02001-3","volume":"25","author":"R Ayash","year":"2025","unstructured":"Ayash R, Kabalan Y, Chamaa S (2025) Association of soluble apoptotic biomarkers (FAS, TNFR1 and TRAIL-R2) with \u03b2-cell dysfunction in early glucose dysregulation. BMC Endocr Disorders 25(1):218. https:\/\/doi.org\/10.1186\/s12902-025-02001-3","journal-title":"BMC Endocr Disorders"},{"issue":"12","key":"1161_CR55","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1055\/a-2191-9969","volume":"131","author":"J Liu","year":"2023","unstructured":"Liu J, Zhang Y, Shi D et al (2023) Vitamin D alleviates type 2 diabetes mellitus by mitigating oxidative stress-induced pancreatic \u03b2-cell impairment. Exp Clin Endocrinol Diabetes 131(12):656\u2013666. https:\/\/doi.org\/10.1055\/a-2191-9969","journal-title":"Exp Clin Endocrinol Diabetes"},{"issue":"1","key":"1161_CR56","doi-asserted-by":"publisher","first-page":"200","DOI":"10.3390\/antiox12010200","volume":"12","author":"Y Chen","year":"2023","unstructured":"Chen Y, Zheng Y, Chen R et al (2023) Dihydromyricetin attenuates diabetic cardiomyopathy by inhibiting oxidative stress, inflammation and necroptosis via Sirtuin 3 activation. Antioxidants 12(1):200. https:\/\/doi.org\/10.3390\/antiox12010200","journal-title":"Antioxidants"},{"issue":"2","key":"1161_CR57","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1038\/s41419-022-04587-1","volume":"13","author":"S Qiao","year":"2022","unstructured":"Qiao S, Hong L, Zhu Y et al (2022) RIPK1-RIPK3 mediates myocardial fibrosis in type 2 diabetes mellitus by impairing autophagic flux of cardiac fibroblasts. Cell Death Dis 13(2):147. https:\/\/doi.org\/10.1038\/s41419-022-04587-1","journal-title":"Cell Death Dis"},{"key":"1161_CR58","doi-asserted-by":"publisher","unstructured":"Sun L, Xiao Y, San W et al (2024) Dihydromyricetin regulates RIPK3-CaMKII to prevent necroptosis in high glucose-stimulated cardiomyocytes. Heliyon 10(7). https:\/\/doi.org\/10.1016\/j.heliyon.2024.e28921","DOI":"10.1016\/j.heliyon.2024.e28921"},{"key":"1161_CR59","doi-asserted-by":"publisher","first-page":"835879","DOI":"10.3389\/fimmu.2022.835879","volume":"13","author":"T Ma","year":"2022","unstructured":"Ma T, Li X, Zhu Y et al (2022) Excessive activation of Notch signaling in macrophages promote kidney inflammation, fibrosis, and necroptosis. Front Immunol 13:835879. https:\/\/doi.org\/10.3389\/fimmu.2022.835879","journal-title":"Front Immunol"},{"issue":"1","key":"1161_CR60","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1186\/s12890-024-03056-z","volume":"24","author":"T Liu","year":"2024","unstructured":"Liu T, Wei H, Zhang L et al (2024) Metformin attenuates lung ischemia-reperfusion injury and necroptosis through AMPK pathway in type 2 diabetic recipient rats. BMC Pulm Med 24(1):237. https:\/\/doi.org\/10.1186\/s12890-024-03056-z","journal-title":"BMC Pulm Med"},{"key":"1161_CR61","doi-asserted-by":"publisher","first-page":"1348043","DOI":"10.3389\/fimmu.2024.1348043","volume":"15","author":"A Banerjee","year":"2024","unstructured":"Banerjee A, Singla DK (2024) MSC exosomes attenuate sterile inflammation and necroptosis associated with TAK1-pJNK-NFKB mediated cardiomyopathy in diabetic ApoE KO mice. Front Immunol 15:1348043. https:\/\/doi.org\/10.3389\/fimmu.2024.1348043","journal-title":"Front Immunol"},{"issue":"18","key":"1161_CR62","doi-asserted-by":"publisher","first-page":"e70868","DOI":"10.1096\/fj.202500772R","volume":"39","author":"DQ Wang","year":"2025","unstructured":"Wang DQ, Wang L, Zhao P et al (2025) Role of necroptosis and neuroinflammation in CSVD-Associated cognitive decline in db\/db mice. FASEB J 39(18):e70868. https:\/\/doi.org\/10.1096\/fj.202500772R","journal-title":"FASEB J"},{"issue":"4","key":"1161_CR63","doi-asserted-by":"publisher","first-page":"193","DOI":"10.3233\/hab-240031","volume":"32","author":"D Abdulrhaman","year":"2024","unstructured":"Abdulrhaman D, Fahad H, Khalil N (2024) Association of serum biomarkers level transforming growth factor-\u03b2 and tumor necrosis factor-\u03b1 with diabetic neuropathy. Hum Antib 32(4):193\u2013199. https:\/\/doi.org\/10.3233\/hab-240031","journal-title":"Hum Antib"},{"key":"1161_CR64","doi-asserted-by":"publisher","first-page":"1596506","DOI":"10.3389\/fnins.2025.1596506","volume":"19","author":"X Zhang","year":"2025","unstructured":"Zhang X, Du P, Bai B et al (2025) The GLP-1 receptor agonist liraglutide inhibits necroptosis and neuroinflammation in a mouse model of parkinson\u2019s disease with diabetes co-morbidity. Front NeuroSci 19:1596506. https:\/\/doi.org\/10.3389\/fnins.2025.1596506","journal-title":"Front NeuroSci"},{"key":"1161_CR65","doi-asserted-by":"publisher","first-page":"101582","DOI":"10.1016\/j.mtbio.2025.101582","volume":"31","author":"Y Pang","year":"2025","unstructured":"Pang Y, Kong L, Li Y et al (2025) PLGA\/HA sustained-release system loaded with liraglutide for the treatment of diabetic periodontitis through Inhibition of necroptosis. Mater Today Bio 31:101582. https:\/\/doi.org\/10.1016\/j.mtbio.2025.101582","journal-title":"Mater Today Bio"},{"issue":"2","key":"1161_CR66","doi-asserted-by":"publisher","first-page":"247","DOI":"10.3390\/biom15020247","volume":"15","author":"H Wang","year":"2025","unstructured":"Wang H, Han J, Kong H et al (2025) The emerging role of m6A and programmed cell death in cardiovascular diseases. Biomolecules 15(2):247. https:\/\/doi.org\/10.3390\/biom15020247","journal-title":"Biomolecules"},{"key":"1161_CR67","doi-asserted-by":"publisher","unstructured":"Dabravolski SA, Kalmykov VA, Maksaeva AO et al (2025) Necroptosis in myocardial ischaemia-reperfusion injury: current update on mechanisms, therapeutic targets, and translational potential. Apoptosis 1-19. https:\/\/doi.org\/10.1007\/s10495-025-02108-x","DOI":"10.1007\/s10495-025-02108-x"},{"issue":"1","key":"1161_CR68","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1038\/s41392-025-02251-6","volume":"10","author":"X Huang","year":"2025","unstructured":"Huang X, Xie M, Wang Y et al (2025) Porphyromonas gingivalis aggravates atherosclerotic plaque instability by promoting lipid-laden macrophage necroptosis. Signal Transduct Target Therapy 10(1):171. https:\/\/doi.org\/10.1038\/s41392-025-02251-6","journal-title":"Signal Transduct Target Therapy"},{"issue":"1","key":"1161_CR69","doi-asserted-by":"publisher","first-page":"2463477","DOI":"10.1080\/02656736.2025.2463477","volume":"42","author":"L Mu","year":"2025","unstructured":"Mu L, Xue S, Tuo W et al (2025) Nec-1 regulates phenotypic transformation of heat stroke-induced vascular smooth muscle cells by inhibiting RIPK1. Int J Hyperth 42(1):2463477. https:\/\/doi.org\/10.1080\/02656736.2025.2463477","journal-title":"Int J Hyperth"},{"key":"1161_CR70","doi-asserted-by":"publisher","first-page":"103400","DOI":"10.1016\/j.redox.2024.103400","volume":"78","author":"M Zhao","year":"2024","unstructured":"Zhao M, Zheng Z, Liu J et al (2024) LGR6 protects against myocardial ischemia-reperfusion injury via suppressing necroptosis. Redox Biol 78:103400. https:\/\/doi.org\/10.1016\/j.redox.2024.103400","journal-title":"Redox Biol"},{"issue":"7","key":"1161_CR71","doi-asserted-by":"publisher","first-page":"e012452","DOI":"10.1161\/CIRCEP.123.012452","volume":"17","author":"X Jin","year":"2024","unstructured":"Jin X, Zhang Y, Zhou Y et al (2024) Sirt1 deficiency promotes age-related AF through enhancing atrial necroptosis by activation of RIPK1 acetylation. Circulation: Arrhythmia Electrophysiol 17(7):e012452. https:\/\/doi.org\/10.1161\/CIRCEP.123.012452","journal-title":"Circulation: Arrhythmia Electrophysiol"},{"key":"1161_CR72","doi-asserted-by":"publisher","first-page":"111344","DOI":"10.1016\/j.cellsig.2024.111344","volume":"122","author":"J Li","year":"2024","unstructured":"Li J, Zhang J, Zhong Y et al (2024) TRPC6 regulates necroptosis in myocardial ischemia\/reperfusion injury via Ca2+\/CaMKII signaling pathway. Cell Signal 122:111344. https:\/\/doi.org\/10.1016\/j.cellsig.2024.111344","journal-title":"Cell Signal"},{"issue":"1","key":"1161_CR73","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1038\/s41420-023-01749-8","volume":"9","author":"J-L Lu","year":"2023","unstructured":"Lu J-L, Li-Jun C-XY Song (2023) Programmed cell death in hepatic fibrosis: current and perspectives. Cell Death Discovery 9(1):449. https:\/\/doi.org\/10.1038\/s41420-023-01749-8","journal-title":"Cell Death Discovery"},{"issue":"12","key":"1161_CR74","doi-asserted-by":"publisher","first-page":"3517","DOI":"10.1007\/s10815-024-03286-4","volume":"41","author":"X Tang","year":"2024","unstructured":"Tang X, Ji J, Zhu L et al (2024) Identification of necroptosis-related gene expression and the immune response in polycystic ovary syndrome. J Assist Reprod Genet 41(12):3517\u20133537. https:\/\/doi.org\/10.1007\/s10815-024-03286-4","journal-title":"J Assist Reprod Genet"},{"issue":"1","key":"1161_CR75","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1186\/s13098-024-01378-w","volume":"16","author":"M Matboli","year":"2024","unstructured":"Matboli M, Al-Amodi HS, Hamady S et al (2024) Experimental investigation for nonalcoholic fatty pancreas management using probiotics. Diabetol Metab Syndr 16(1):147. https:\/\/doi.org\/10.1186\/s13098-024-01378-w","journal-title":"Diabetol Metab Syndr"},{"key":"1161_CR76","doi-asserted-by":"publisher","first-page":"112745","DOI":"10.1016\/j.intimp.2024.112745","volume":"139","author":"RB He","year":"2024","unstructured":"He RB, Li W, Yao R et al (2024) Aurantiamide mitigates acute kidney injury by suppressing renal necroptosis and inflammation via GRPR-dependent mechanism. Int Immunopharmacol 139:112745. https:\/\/doi.org\/10.1016\/j.intimp.2024.112745","journal-title":"Int Immunopharmacol"},{"key":"1161_CR77","doi-asserted-by":"publisher","first-page":"135978","DOI":"10.1016\/j.ijbiomac.2024.135978","volume":"280","author":"HW Chiu","year":"2024","unstructured":"Chiu HW, Lu KC, Lin YC et al (2024) Etelcalcetide ameliorates bone loss in chronic kidney disease-mineral and bone disorder by activation of IRF7 and necroptosis pathways. Int J Biol Macromol 280:135978. https:\/\/doi.org\/10.1016\/j.ijbiomac.2024.135978","journal-title":"Int J Biol Macromol"},{"issue":"1","key":"1161_CR78","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1038\/s41538-024-00318-2","volume":"8","author":"XH Huang","year":"2024","unstructured":"Huang XH, Huang CY (2024) Fructose shields human colorectal cancer cells from hypoxia-induced necroptosis. Npj Sci Food 8(1):71. https:\/\/doi.org\/10.1038\/s41538-024-00318-2","journal-title":"Npj Sci Food"},{"issue":"2","key":"1161_CR79","first-page":"181","volume":"20","author":"AB Haloho","year":"2025","unstructured":"Haloho AB, Amin R, Saleh MI et al (2025) Clinical implications of necroptosis biomarkers in sepsis. Tec Empresarial 20(2):181\u2013195","journal-title":"Tec Empresarial"},{"issue":"1","key":"1161_CR80","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.jhep.2025.07.034","volume":"84","author":"N Verma","year":"2025","unstructured":"Verma N, Garg P, Kaur P et al (2025) Identification and validation of RIPK3 as a novel biomarker to predict outcomes in patients with acutely decompensated cirrhosis. J Hepatol 84(1):99\u2013112. https:\/\/doi.org\/10.1016\/j.jhep.2025.07.034","journal-title":"J Hepatol"},{"issue":"3","key":"1161_CR81","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1007\/s11064-025-04448-1","volume":"50","author":"A Kang","year":"2025","unstructured":"Kang A, Qiao Y, Pan S et al (2025) From RIPK1 to necroptosis: pathogenic mechanisms in neurodegenerative diseases. Neurochem Res 50(3):194. https:\/\/doi.org\/10.1007\/s11064-025-04448-1","journal-title":"Neurochem Res"},{"issue":"35","key":"1161_CR82","doi-asserted-by":"publisher","first-page":"e09277","DOI":"10.1002\/advs.202509277","volume":"12","author":"L Xu","year":"2025","unstructured":"Xu L, Zhuang C (2025) Mixed lineage kinase Domain-Like protein (MLKL): from mechanisms to therapeutic opportunities. Adv Sci 12(35):e09277. https:\/\/doi.org\/10.1002\/advs.202509277","journal-title":"Adv Sci"},{"key":"1161_CR83","doi-asserted-by":"publisher","first-page":"3878","DOI":"10.1007\/s10753-025-02298-1","volume":"48","author":"J Sun","year":"2025","unstructured":"Sun J, Wu W, Wang Y et al (2025) MLKL\u2013Mediated necroptosis predominantly contributes to Immune-Associated myocardial damage. Inflammation 48:3878\u20133897. https:\/\/doi.org\/10.1007\/s10753-025-02298-1","journal-title":"Inflammation"},{"issue":"1","key":"1161_CR84","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/s10565-024-09893-2","volume":"40","author":"JY Yuan","year":"2024","unstructured":"Yuan JY, Guo L, Ma JT et al (2024) HMGB1 as an extracellular pro-inflammatory cytokine: implications for drug-induced organic damage. Cell Biol Toxicol 40(1):55. https:\/\/doi.org\/10.1007\/s10565-024-09893-2","journal-title":"Cell Biol Toxicol"},{"key":"1161_CR85","doi-asserted-by":"publisher","unstructured":"Chen Q, Zhang JL, Yang JS et al (2024) Novel diagnostic biomarkers related to necroptosis and immune infiltration in coronary heart disease. J Inflamm Res 4525\u20134548. https:\/\/doi.org\/10.2147\/JIR.S457469","DOI":"10.2147\/JIR.S457469"},{"issue":"1","key":"1161_CR86","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s41065-024-00309-z","volume":"161","author":"H Zhang","year":"2024","unstructured":"Zhang H, He Y, Zhao Y et al (2024) Identification of necroptosis genes and characterization of immune infiltration in non-alcoholic steatohepatitis. Hereditas 161(1):32. https:\/\/doi.org\/10.1186\/s41065-024-00309-z","journal-title":"Hereditas"},{"key":"1161_CR87","doi-asserted-by":"publisher","unstructured":"You H, Han W (2024) Identification of necroptosis-related diagnostic biomarkers in coronary heart disease. Heliyon 10(9). https:\/\/doi.org\/10.1016\/j.heliyon.2024.e30269","DOI":"10.1016\/j.heliyon.2024.e30269"},{"issue":"8","key":"1161_CR88","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1016\/j.pan.2024.11.016","volume":"24","author":"H Belfrage","year":"2024","unstructured":"Belfrage H, Kuuliala K, Kuuliala A et al (2024) Circulating necroptosis markers in chronic pancreatitis and pancreatic cancer: associations with diagnosis and prognostic factors. Pancreatology 24(8):1229\u20131236. https:\/\/doi.org\/10.1016\/j.pan.2024.11.016","journal-title":"Pancreatology"},{"issue":"5","key":"1161_CR89","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1007\/s11011-023-01185-8","volume":"38","author":"K Preeti","year":"2023","unstructured":"Preeti K, Fernandes V, Sood A et al (2023) Necrostatin-1S mitigates type-2 diabetes-associated cognitive decrement and lipotoxicity-induced neuro-microglia changes through p-RIPK-RIPK3-p-MLKL axis. Metab Brain Dis 38(5):1581\u20131612. https:\/\/doi.org\/10.1007\/s11011-023-01185-8","journal-title":"Metab Brain Dis"},{"key":"1161_CR90","doi-asserted-by":"publisher","first-page":"1640657","DOI":"10.3389\/fimmu.2025.1640657","volume":"16","author":"H Sun","year":"2025","unstructured":"Sun H, Xu M, Mi D et al (2025) Diagnostic LncRNA biomarkers and immune-related CeRNA networks for osteonecrosis of the femoral head in metabolic syndrome identified by plasma RNA sequencing and machine learning. Front Immunol 16:1640657. https:\/\/doi.org\/10.3389\/fimmu.2025.1640657","journal-title":"Front Immunol"},{"issue":"1","key":"1161_CR91","doi-asserted-by":"publisher","first-page":"58","DOI":"10.21608\/rpbs.2025.363330.1359","volume":"9","author":"AO Hamouda","year":"2025","unstructured":"Hamouda AO, Abo-El-Matty D, Khedr NF et al (2025) Apoptosis and necroptosis pathways in nonalcoholic steatohepatitis; new strategy for treatment. Records Pharm Biomedical Sci 9(1):58\u201369. https:\/\/doi.org\/10.21608\/rpbs.2025.363330.1359","journal-title":"Records Pharm Biomedical Sci"},{"issue":"10","key":"1161_CR92","doi-asserted-by":"publisher","first-page":"2713","DOI":"10.21037\/tlcr-24-627","volume":"13","author":"C Lin","year":"2024","unstructured":"Lin C, Lin K, Lin X et al (2024) Necroptosis-related lncrnas: biomarkers for predicting prognosis and immune response in lung adenocarcinoma. Translational Lung Cancer Res 13(10):2713\u20132728. https:\/\/doi.org\/10.21037\/tlcr-24-627","journal-title":"Translational Lung Cancer Res"},{"issue":"6","key":"1161_CR93","doi-asserted-by":"publisher","first-page":"1476","DOI":"10.1093\/jalm\/jfaf124","volume":"10","author":"MM Watany","year":"2025","unstructured":"Watany MM, Elhosary MM (2025) Differential NADP-Dependent isocitrate dehydrogenases expression in metabolically healthy obesity vs metabolic syndrome: A probable predictive biomarker for metabolic deterioration. J Appl Lab Med 10(6):1476\u20131490. https:\/\/doi.org\/10.1093\/jalm\/jfaf124","journal-title":"J Appl Lab Med"},{"issue":"12","key":"1161_CR94","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.3390\/biom14121629","volume":"14","author":"KAF Pennel","year":"2024","unstructured":"Pennel KAF, Kurniawan A, Samir Foad Al-Badran S et al (2024) IL6 and IL6R as prognostic biomarkers in colorectal cancer. Biomolecules 14(12):1629. https:\/\/doi.org\/10.3390\/biom14121629","journal-title":"Biomolecules"},{"issue":"12","key":"1161_CR95","doi-asserted-by":"publisher","first-page":"4234","DOI":"10.3390\/jcm14124234","volume":"14","author":"D A\u011fag\u00fcnd\u00fcz","year":"2025","unstructured":"A\u011fag\u00fcnd\u00fcz D, \u00c7elik MN, Deniz G\u00fcne\u015f B et al (2025) Involvement of MiRNAs in the cluster of metabolic factors of mets: Nutrition-Genome-MetS axis. J Clin Med 14(12):4234. https:\/\/doi.org\/10.3390\/jcm14124234","journal-title":"J Clin Med"},{"issue":"1","key":"1161_CR96","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s13098-024-01574-8","volume":"17","author":"D Xing","year":"2025","unstructured":"Xing D, Xu J, Weng X et al (2025) Correlation between estimated glucose disposal rate, insulin resistance, and cardiovascular mortality among individuals with metabolic syndrome: a population-based analysis, evidence from NHANES 1999\u20132018. Diabetol Metab Syndr 17(1):11. https:\/\/doi.org\/10.1186\/s13098-024-01574-8","journal-title":"Diabetol Metab Syndr"},{"key":"1161_CR97","doi-asserted-by":"publisher","first-page":"114761","DOI":"10.1016\/j.intimp.2025.114761","volume":"157","author":"Z Zhou","year":"2025","unstructured":"Zhou Z, Sun N, Duan L et al (2025) Theaflavin suppresses necroptosis by attenuating RIPK1-RIPK3-MLKL signaling and mitigates cisplatin-induced kidney injury in mice. Int Immunopharmacol 157:114761. https:\/\/doi.org\/10.1016\/j.intimp.2025.114761","journal-title":"Int Immunopharmacol"},{"issue":"7","key":"1161_CR98","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1038\/s41417-024-00765-9","volume":"31","author":"J Gao","year":"2024","unstructured":"Gao J, Xiong A, Liu J et al (2024) PANoptosis: bridging apoptosis, pyroptosis, and necroptosis in cancer progression and treatment. Cancer Gene Ther 31(7):970\u2013983. https:\/\/doi.org\/10.1038\/s41417-024-00765-9","journal-title":"Cancer Gene Ther"},{"issue":"4","key":"1161_CR99","doi-asserted-by":"publisher","first-page":"2361","DOI":"10.1021\/acs.jmedchem.2c01621","volume":"66","author":"CR Gardner","year":"2023","unstructured":"Gardner CR, Davies KA, Zhang Y et al (2023) From (tool) bench to bedside: the potential of necroptosis inhibitors. J Med Chem 66(4):2361\u20132385. https:\/\/doi.org\/10.1021\/acs.jmedchem.2c01621","journal-title":"J Med Chem"},{"issue":"1","key":"1161_CR100","doi-asserted-by":"publisher","first-page":"6043","DOI":"10.1038\/s41467-024-50450-6","volume":"15","author":"CY Liao","year":"2024","unstructured":"Liao CY, Li G, Kang FP et al (2024) Necroptosis enhances \u2018don\u2019t eat me\u2019signal and induces macrophage extracellular traps to promote pancreatic cancer liver metastasis. Nat Commun 15(1):6043. https:\/\/doi.org\/10.1038\/s41467-024-50450-6","journal-title":"Nat Commun"},{"issue":"4","key":"1161_CR101","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1007\/s00011-023-01694-3","volume":"72","author":"S Bian","year":"2023","unstructured":"Bian S, Yang L, Zhao D et al (2023) HMGB1\/TLR4 signaling pathway enhances abdominal aortic aneurysm progression in mice by upregulating necroptosis. Inflamm Res 72(4):703\u2013713. https:\/\/doi.org\/10.1007\/s00011-023-01694-3","journal-title":"Inflamm Res"},{"issue":"1","key":"1161_CR102","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1186\/s12872-024-04284-1","volume":"24","author":"M Wang","year":"2024","unstructured":"Wang M, Ma G, Tao Z (2024) The association of neutrophil-to-lymphocyte ratio with cardiovascular and all-cause mortality among the metabolic syndrome population. BMC Cardiovasc Disord 24(1):594. https:\/\/doi.org\/10.1186\/s12872-024-04284-1","journal-title":"BMC Cardiovasc Disord"},{"issue":"11","key":"1161_CR103","doi-asserted-by":"publisher","first-page":"e2400459","DOI":"10.1002\/ardp.202400459","volume":"357","author":"Y Zheng","year":"2024","unstructured":"Zheng Y, Zhang X, Wang Z et al (2024) MCC950 as a promising candidate for blocking NLRP3 inflammasome activation: A review of preclinical research and future directions. Arch Pharm 357(11):e2400459. https:\/\/doi.org\/10.1002\/ardp.202400459","journal-title":"Arch Pharm"},{"issue":"1","key":"1161_CR104","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1038\/s41420-024-02168-z","volume":"10","author":"H Xu","year":"2024","unstructured":"Xu H, Wan S, An Y et al (2024) Targeting cell death in NAFLD: mechanisms and targeted therapies. Cell Death Discovery 10(1):399. https:\/\/doi.org\/10.1038\/s41420-024-02168-z","journal-title":"Cell Death Discovery"},{"key":"1161_CR105","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.trsl.2021.01.006","volume":"239","author":"T Camino","year":"2022","unstructured":"Camino T et al (2022) Human obese white adipose tissue sheds depot-specific extracellular vesicles and reveals candidate biomarkers for monitoring obesity and its comorbidities. Translational Res 239:85\u2013102. https:\/\/doi.org\/10.1016\/j.trsl.2021.01.006","journal-title":"Translational Res"},{"issue":"1","key":"1161_CR106","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s12944-024-02396-3","volume":"24","author":"S Gurjar","year":"2025","unstructured":"Gurjar S, Bhat AR, Upadhya R et al (2025) Extracellular vesicle-mediated approaches for the diagnosis and therapy of MASLD: current advances and future prospective. Lipids Health Dis 24(1):5. https:\/\/doi.org\/10.1186\/s12944-024-02396-3","journal-title":"Lipids Health Dis"},{"issue":"1","key":"1161_CR107","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1038\/s41420-024-01799-6","volume":"10","author":"YC Yang","year":"2024","unstructured":"Yang YC, Jiang Q, Yang KP et al (2024) Extracellular vesicle-mediated ferroptosis, pyroptosis, and necroptosis: potential clinical applications in cancer therapy. Cell Death Discovery 10(1):23. https:\/\/doi.org\/10.1038\/s41420-024-01799-6","journal-title":"Cell Death Discovery"},{"key":"1161_CR108","doi-asserted-by":"publisher","first-page":"101988","DOI":"10.1016\/j.molmet.2024.101988","volume":"87","author":"\u00d6 Veli","year":"2024","unstructured":"Veli \u00d6, Kaya \u00d6, Varanda AB et al (2024) RIPK1 is dispensable for cell death regulation in \u03b2-cells during hyperglycemia. Mol Metabolism 87:101988. https:\/\/doi.org\/10.1016\/j.molmet.2024.101988","journal-title":"Mol Metabolism"},{"issue":"1","key":"1161_CR109","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1038\/s41419-025-07563-7","volume":"16","author":"Z Muszka","year":"2025","unstructured":"Muszka Z, Jenei V, M\u00e1csik R et al (2025) Life-threatening risk factors contribute to the development of diseases with the highest mortality through the induction of regulated necrotic cell death. Cell Death Dis 16(1):273. https:\/\/doi.org\/10.1038\/s41419-025-07563-7","journal-title":"Cell Death Dis"},{"key":"1161_CR110","doi-asserted-by":"publisher","first-page":"1274654","DOI":"10.3389\/fimmu.2023.1274654","volume":"14","author":"D Ke","year":"2023","unstructured":"Ke D, Zhang Z, Liu J et al (2023) RIPK1 and RIPK3 inhibitors: potential weapons against inflammation to treat diabetic complications. Front Immunol 14:1274654. https:\/\/doi.org\/10.3389\/fimmu.2023.1274654","journal-title":"Front Immunol"},{"issue":"1","key":"1161_CR111","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1038\/s41392-024-01771-x","volume":"9","author":"Y-L Xiao","year":"2024","unstructured":"Xiao Y-L et al (2024) Effects of dietary intervention on human diseases: molecular mechanisms and therapeutic potential. Signal Transduct Target Therapy 9(1):59. https:\/\/doi.org\/10.1038\/s41392-024-01771-x","journal-title":"Signal Transduct Target Therapy"},{"issue":"7","key":"1161_CR112","doi-asserted-by":"publisher","first-page":"e13910","DOI":"10.1111\/obr.13910","volume":"26","author":"C Bulmer","year":"2025","unstructured":"Bulmer C, Avenell A (2025) The effect of dietary weight-loss interventions on the inflammatory markers interleukin\u20106 and TNF\u2010alpha in adults with obesity: A systematic review and meta\u2010analysis of randomized controlled clinical trials. Obes Rev 26(7):e13910. https:\/\/doi.org\/10.1111\/obr.13910","journal-title":"Obes Rev"},{"issue":"6","key":"1161_CR113","doi-asserted-by":"publisher","first-page":"327","DOI":"10.3390\/metabo14060327","volume":"14","author":"G Martemucci","year":"2025","unstructured":"Martemucci G, Khalil M, Di Luca A et al (2025) Comprehensive strategies for metabolic syndrome: how nutrition, dietary polyphenols, physical activity, and lifestyle modifications address diabesity, cardiovascular diseases, and neurodegenerative conditions. Metabolites 14(6):327. https:\/\/doi.org\/10.3390\/metabo14060327","journal-title":"Metabolites"},{"key":"1161_CR114","doi-asserted-by":"publisher","unstructured":"Crawley MR, Hildebrand JM, Murphy JM et al (2023) Divergent roles for caspase-8 and MLKL in high-fat diet induced obesity and NAFLD in mice. BioRxiv. https:\/\/doi.org\/10.1101\/2023.03.14.532682","DOI":"10.1101\/2023.03.14.532682"},{"issue":"1","key":"1161_CR115","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1007\/s10495-024-02038-0","volume":"30","author":"S Wei","year":"2025","unstructured":"Wei S, Han C, Mo S et al (2025) Advancements in programmed cell death research in antitumor therapy: a comprehensive overview. Apoptosis 30(1):401\u2013421. https:\/\/doi.org\/10.1007\/s10495-024-02038-0","journal-title":"Apoptosis"},{"key":"1161_CR116","doi-asserted-by":"publisher","unstructured":"Kopeina GS, Efimenko AY, Tkachuk VA et al (2025) Programmed cell death and tissue regeneration: A link that should be resolved. Physiol Rev 105(4). https:\/\/doi.org\/10.1152\/physrev.00036.2024","DOI":"10.1152\/physrev.00036.2024"},{"key":"1161_CR117","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2025.05.055","author":"CY Lian","year":"2025","unstructured":"Lian CY, Xia WH, Sun MC et al (2025) Cadmium targeting MLKL-Drp1 axis to trigger mitochondrial oxidative stress contributes to necroinflammation in rat kidney. J Adv Researc. https:\/\/doi.org\/10.1016\/j.jare.2025.05.055","journal-title":"J Adv Researc"},{"key":"1161_CR118","unstructured":"Benjamin M (2025) The relationship between metabolic syndrome. NF-\u03baB Signaling, and Cardiovascular Disease"},{"issue":"3","key":"1161_CR119","doi-asserted-by":"publisher","first-page":"e70031","DOI":"10.1002\/mef2.70031","volume":"4","author":"Y Wu","year":"2025","unstructured":"Wu Y, Yang S, Zhang Y et al (2025) Exosomes in metabolic diseases: from molecular mechanisms to clinical applications. MedComm\u2013Future Med 4(3):e70031. https:\/\/doi.org\/10.1002\/mef2.70031","journal-title":"MedComm\u2013Future Med"}],"container-title":["Journal of Physiology and Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13105-026-01161-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13105-026-01161-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13105-026-01161-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T02:51:44Z","timestamp":1772247104000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13105-026-01161-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,28]]},"references-count":119,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["1161"],"URL":"https:\/\/doi.org\/10.1007\/s13105-026-01161-7","relation":{},"ISSN":["1138-7548","1877-8755"],"issn-type":[{"value":"1138-7548","type":"print"},{"value":"1877-8755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,28]]},"assertion":[{"value":"23 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Not applicable.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"<!--Emphasis Type='Bold' removed-->Clinical trial number"}}],"article-number":"17"}}