{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T09:35:16Z","timestamp":1773999316188,"version":"3.50.1"},"reference-count":233,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:00:00Z","timestamp":1773964800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:00:00Z","timestamp":1773964800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Physiol Biochem"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s13105-026-01171-5","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T04:25:19Z","timestamp":1773980719000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the role of metabolic disorders and gut microbiome in immune checkpoint regulation in cancer: PI3K\/AKT\/mTOR focus"],"prefix":"10.1007","volume":"82","author":[{"given":"Azam","family":"Abedi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehrdad Moosazadeh","family":"Moghaddam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza","family":"kachuei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abbas Ali Imani","family":"Fooladi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,20]]},"reference":[{"key":"1171_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2025.112802","author":"Q Wang","year":"2025","unstructured":"Wang Q, Li J, Qiao H, Zhang Y, Xu Y, Chen R, Liu K, Zhang S, Zhuang G (2025) Metabolic syndrome and cancer risk: a bidirectional two-sample Mendelian randomization study. Exp Gerontol. https:\/\/doi.org\/10.1016\/j.exger.2025.112802","journal-title":"Exp Gerontol"},{"issue":"3","key":"1171_CR2","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1002\/aac2.12073","volume":"5","author":"I Kareva","year":"2024","unstructured":"Kareva I (2024) From hyperinsulinemia to cancer progression: how diminishing glucose storage capacity fuels insulin resistance. Aging Cancer 5(3):51\u201361","journal-title":"Aging Cancer"},{"issue":"1","key":"1171_CR3","doi-asserted-by":"publisher","DOI":"10.1007\/s12672-024-01662-1","volume":"15","author":"S Anand","year":"2024","unstructured":"Anand S, Patel TN (2024) Integrating the metabolic and molecular circuits in diabetes, obesity and cancer: a comprehensive review. Discover Oncol 15(1):779","journal-title":"Discover Oncol"},{"issue":"19","key":"1171_CR4","doi-asserted-by":"publisher","first-page":"2132","DOI":"10.3390\/diagnostics14192132","volume":"14","author":"A Asiri","year":"2024","unstructured":"Asiri A, Al Qarni A, Bakillah A (2024) The interlinking metabolic association between type 2 diabetes mellitus and cancer: molecular mechanisms and therapeutic insights. Diagnostics 14(19):2132","journal-title":"Diagnostics"},{"issue":"1","key":"1171_CR5","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-47359-5","volume":"15","author":"A Piening","year":"2024","unstructured":"Piening A, Ebert E, Gottlieb C, Khojandi N, Kuehm LM, Hoft SG, Pyles KD, McCommis KS, DiPaolo RJ, Ferris ST (2024) Obesity-related T cell dysfunction impairs immunosurveillance and increases cancer risk. Nat Commun 15(1):2835","journal-title":"Nat Commun"},{"key":"1171_CR6","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.703681","volume":"11","author":"S Zheng","year":"2021","unstructured":"Zheng S, Song Q, Zhang P (2021) Metabolic modifications, inflammation, and cancer immunotherapy. Front Oncol 11:703681","journal-title":"Front Oncol"},{"issue":"1","key":"1171_CR7","doi-asserted-by":"publisher","DOI":"10.1038\/s41522-025-00678-x","volume":"11","author":"J Sun","year":"2025","unstructured":"Sun J, Song S, Liu J, Chen F, Li X, Wu G (2025) Gut microbiota as a new target for anticancer therapy: from mechanism to means of regulation. NPJ Biofilms Microbiomes 11(1):43","journal-title":"NPJ Biofilms Microbiomes"},{"issue":"1","key":"1171_CR8","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-89801-8","volume":"15","author":"EM Abdelqader","year":"2025","unstructured":"Abdelqader EM, Mahmoud WS, Gebreel HM, Kamel MM, Abu-Elghait M (2025) Correlation between gut microbiota dysbiosis, metabolic syndrome and breast cancer. Sci Rep 15(1):6652","journal-title":"Sci Rep"},{"issue":"1","key":"1171_CR9","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/128076","volume":"2018","author":"JE Beliz\u00e1rio","year":"2018","unstructured":"Beliz\u00e1rio JE, Faintuch J, Garay-Malpartida M (2018) Gut microbiome dysbiosis and immunometabolism: new frontiers for treatment of metabolic diseases. Mediators Inflamm 2018(1):2037838","journal-title":"Mediators Inflamm"},{"key":"1171_CR10","doi-asserted-by":"publisher","first-page":"1882","DOI":"10.3389\/fimmu.2017.01882","volume":"8","author":"X Li","year":"2017","unstructured":"Li X, Watanabe K, Kimura I (2017) Gut microbiota dysbiosis drives and implies novel therapeutic strategies for diabetes mellitus and related metabolic diseases. Front Immunol 8:1882","journal-title":"Front Immunol"},{"issue":"12","key":"1171_CR11","doi-asserted-by":"publisher","DOI":"10.3390\/nu16121938","volume":"16","author":"E M\u0142ynarska","year":"2024","unstructured":"M\u0142ynarska E, Wasiak J, Gajewska A, Ste\u0107 G, Jasi\u0144ska J, Rysz J, Franczyk B (2024) Exploring the significance of gut microbiota in diabetes pathogenesis and management\u2014a narrative review. Nutrients 16(12):1938","journal-title":"Nutrients"},{"issue":"11","key":"1171_CR12","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-04293-4","volume":"12","author":"H Yin","year":"2021","unstructured":"Yin H, Pu N, Chen Q, Zhang J, Zhao G, Xu X, Wang D, Kuang T, Jin D, Lou W (2021) Gut-derived lipopolysaccharide remodels tumoral microenvironment and synergizes with PD-L1 checkpoint blockade via TLR4\/MyD88\/AKT\/NF-\u03baB pathway in pancreatic cancer. Cell Death Dis 12(11):1033","journal-title":"Cell Death Dis"},{"key":"1171_CR13","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1096551","volume":"13","author":"M Wang","year":"2023","unstructured":"Wang M, Zhang L, Chang W, Zhang Y (2023) The crosstalk between the gut microbiota and tumor immunity: implications for cancer progression and treatment outcomes. Front Immunol 13:1096551","journal-title":"Front Immunol"},{"key":"1171_CR14","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1444589","volume":"15","author":"AS Yende","year":"2024","unstructured":"Yende AS, Sharma D (2024) Obesity, dysbiosis and inflammation: interactions that modulate the efficacy of immunotherapy. Front Immunol 15:1444589","journal-title":"Front Immunol"},{"issue":"1","key":"1171_CR15","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/s12934-020-01330-3","volume":"19","author":"K Kesh","year":"2020","unstructured":"Kesh K, Mendez R, Abdelrahman L, Banerjee S, Banerjee S (2020) Type 2 diabetes induced microbiome dysbiosis is associated with therapy resistance in pancreatic adenocarcinoma. Microb Cell Fact 19(1):75","journal-title":"Microb Cell Fact"},{"issue":"6","key":"1171_CR16","doi-asserted-by":"publisher","first-page":"R173","DOI":"10.1530\/ERC-20-0315","volume":"28","author":"M Guti\u00e9rrez-Salmer\u00f3n","year":"2021","unstructured":"Guti\u00e9rrez-Salmer\u00f3n M, Lucena SR, Chocarro-Calvo A, Garc\u00eda-Mart\u00ednez JM, Orozco RMM (2021) Garc\u00eda-Jim\u00e9nez, Remodelling of colorectal cancer cell signalling by microbiota and immunity in diabetes. Endocrine-related Cancer 28(6):R173\u2013R190","journal-title":"Endocrine-related Cancer"},{"key":"1171_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13046-021-02201-4","volume":"41","author":"Y Chen","year":"2022","unstructured":"Chen Y, Liu Y, Wang Y, Chen X, Wang C, Chen X, Yuan X, Liu L, Yang J, Zhou X (2022) Prevotellaceae produces butyrate to alleviate PD-1\/PD-L1 inhibitor-related cardiotoxicity via PPAR\u03b1-CYP4X1 axis in colonic macrophages. J Experimental Clin Cancer Res 41:1\u201321","journal-title":"J Experimental Clin Cancer Res"},{"issue":"6371","key":"1171_CR18","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1126\/science.aan4236","volume":"359","author":"V Gopalakrishnan","year":"2018","unstructured":"Gopalakrishnan V, Spencer CN, Nezi L, Reuben A, Andrews MC, Karpinets TV, Prieto P, Vicente D, Hoffman K, Wei SC (2018) Gut microbiome modulates response to anti\u2013PD-1 immunotherapy in melanoma patients. Science 359(6371):97\u2013103","journal-title":"Science"},{"issue":"4","key":"1171_CR19","doi-asserted-by":"publisher","first-page":"e202895","DOI":"10.1001\/jamanetworkopen.2020.2895","volume":"3","author":"M Nomura","year":"2020","unstructured":"Nomura M, Nagatomo R, Doi K, Shimizu J, Baba K, Saito T, Matsumoto S, Inoue K, Muto M (2020) Association of short-chain fatty acids in the gut microbiome with clinical response to treatment with nivolumab or pembrolizumab in patients with solid cancer tumors. JAMA Netw Open 3(4):e202895\u2013e202895","journal-title":"JAMA Netw Open"},{"issue":"53","key":"1171_CR20","doi-asserted-by":"publisher","first-page":"27160","DOI":"10.1074\/jbc.M116.763235","volume":"291","author":"NC Law","year":"2016","unstructured":"Law NC, White MF, Hunzicker-Dunn ME (2016) G protein-coupled receptors (GPCRs) that signal via protein kinase A (PKA) cross-talk at insulin receptor substrate 1 (IRS1) to activate the phosphatidylinositol 3-kinase (PI3K)\/AKT pathway. J Biol Chem 291(53):27160\u201327169","journal-title":"J Biol Chem"},{"issue":"5","key":"1171_CR21","doi-asserted-by":"publisher","first-page":"191","DOI":"10.3390\/curroncol13050019","volume":"13","author":"V Sangwan","year":"2006","unstructured":"Sangwan V, Park M (2006) Receptor tyrosine kinases: role in cancer progression. Curr Oncol 13(5):191","journal-title":"Curr Oncol"},{"issue":"2","key":"1171_CR22","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1038\/s41568-019-0216-7","volume":"20","author":"G Hoxhaj","year":"2020","unstructured":"Hoxhaj G, Manning BD (2020) The PI3K\u2013AKT network at the interface of oncogenic signalling and cancer metabolism. Nat Rev Cancer 20(2):74\u201388","journal-title":"Nat Rev Cancer"},{"issue":"5","key":"1171_CR23","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1038\/nrm2882","volume":"11","author":"B Vanhaesebroeck","year":"2010","unstructured":"Vanhaesebroeck B, Guillermet-Guibert J, Graupera M, Bilanges B (2010) The emerging mechanisms of isoform-specific PI3K signalling. Nat Rev Mol Cell Biol 11(5):329\u2013341","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"5","key":"1171_CR24","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1242\/jcs.093773","volume":"127","author":"S Jean","year":"2014","unstructured":"Jean S, Kiger AA (2014) Classes of phosphoinositide 3-kinases at a glance. J Cell Sci 127(5):923\u2013928","journal-title":"J Cell Sci"},{"issue":"1","key":"1171_CR25","doi-asserted-by":"publisher","first-page":"173","DOI":"10.3390\/ijms22010173","volume":"22","author":"D Miricescu","year":"2020","unstructured":"Miricescu D, Totan A, Stanescu-Spinu I-I, Badoiu SC, Stefani C, Greabu M (2020) PI3K\/AKT\/mTOR signaling pathway in breast cancer: from molecular landscape to clinical aspects. Int J Mol Sci 22(1):173","journal-title":"Int J Mol Sci"},{"issue":"4","key":"1171_CR26","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1016\/j.cell.2017.07.029","volume":"170","author":"DA Fruman","year":"2017","unstructured":"Fruman DA, Chiu H, Hopkins BD, Bagrodia S, Cantley LC, Abraham RT (2017) The PI3K pathway in human disease. Cell 170(4):605\u2013635","journal-title":"Cell"},{"issue":"1","key":"1171_CR27","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09514-1","volume":"10","author":"C Araiz","year":"2019","unstructured":"Araiz C, Yan A, Bettedi L, Samuelson I, Virtue S, McGavigan AK, Dani C, Vidal-Puig A, Foukas LC (2019) Enhanced \u03b2-adrenergic signalling underlies an age-dependent beneficial metabolic effect of PI3K p110\u03b1 inactivation in adipose tissue. Nat Commun 10(1):1546","journal-title":"Nat Commun"},{"issue":"1","key":"1171_CR28","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.ymthe.2023.11.021","volume":"32","author":"MB Arasi","year":"2024","unstructured":"Arasi MB, De Luca G, Chronopoulou L, Pedini F, Petrucci E, Flego M, Stringaro A, Colone M, Pasquini L, Spada M (2024) MiR126-targeted-nanoparticles combined with PI3K\/AKT inhibitor as a new strategy to overcome melanoma resistance. Mol Ther 32(1):152\u2013167","journal-title":"Mol Ther"},{"issue":"6","key":"1171_CR29","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1158\/2159-8290.CD-17-0867","volume":"8","author":"HB Pearson","year":"2018","unstructured":"Pearson HB, Li J, Meniel VS, Fennell CM, Waring P, Montgomery KG, Rebello RJ, Macpherson AA, Koushyar S, Furic L (2018) Identification of Pik3ca mutation as a genetic driver of prostate cancer that cooperates with Pten loss to accelerate progression and castration-resistant growth. Cancer Discov 8(6):764\u2013779","journal-title":"Cancer Discov"},{"issue":"3","key":"1171_CR30","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24032046","volume":"24","author":"E Tortorella","year":"2023","unstructured":"Tortorella E, Giantulli S, Sciarra A, Silvestri I (2023) AR and PI3K\/AKT in prostate cancer: a tale of two interconnected pathways. Int J Mol Sci 24(3):2046","journal-title":"Int J Mol Sci"},{"issue":"10","key":"1171_CR31","doi-asserted-by":"publisher","first-page":"5254","DOI":"10.3390\/ijms25105254","volume":"25","author":"SM M\u00fcller","year":"2024","unstructured":"M\u00fcller SM, J\u00fccker M (2024) The functional roles of the Src homology 2 domain-containing inositol 5-phosphatases SHIP1 and SHIP2 in the pathogenesis of human diseases. Int J Mol Sci 25(10):5254","journal-title":"Int J Mol Sci"},{"issue":"16","key":"1171_CR32","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241612665","volume":"24","author":"A Tsay","year":"2023","unstructured":"Tsay A, Wang J-C (2023) The role of PIK3R1 in metabolic function and insulin sensitivity. Int J Mol Sci 24(16):12665","journal-title":"Int J Mol Sci"},{"issue":"1","key":"1171_CR33","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1042\/BST20150214","volume":"44","author":"MJ Eramo","year":"2016","unstructured":"Eramo MJ, Mitchell CA (2016) Regulation of PtdIns (3, 4, 5) P 3\/Akt signalling by inositol polyphosphate 5-phosphatases. Biochem Soc Trans 44(1):240\u2013252","journal-title":"Biochem Soc Trans"},{"key":"1171_CR34","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.jbior.2017.06.003","volume":"65","author":"MA Hermida","year":"2017","unstructured":"Hermida MA, Kumar JD, Leslie NR (2017) GSK3 and its interactions with the PI3K\/AKT\/mTOR signalling network. Adv Biol Regul 65:5\u201315","journal-title":"Adv Biol Regul"},{"key":"1171_CR35","first-page":"80","volume-title":"Seminars in cancer biology","author":"S Revathidevi","year":"2019","unstructured":"Revathidevi S, Munirajan AK (2019) Akt in cancer: Mediator and more. Seminars in cancer biology. Elsevier, pp 80\u201391"},{"issue":"7152","key":"1171_CR36","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1038\/nature05933","volume":"448","author":"JD Carpten","year":"2007","unstructured":"Carpten JD, Faber AL, Horn C, Donoho GP, Briggs SL, Robbins CM, Hostetter G, Boguslawski S, Moses TY, Savage S (2007) A transforming mutation in the pleckstrin homology domain of AKT1 in cancer. Nature 448(7152):439\u2013444","journal-title":"Nature"},{"key":"1171_CR37","doi-asserted-by":"crossref","unstructured":"Menges CW, Hassan D, Cheung M, Bellacosa A, Testa JR (2024) Alterations of the AKT pathway in sporadic human tumors, inherited susceptibility to cancer, and overgrowth syndromes. Springer","DOI":"10.1007\/82_2024_278"},{"issue":"1","key":"1171_CR38","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1007\/s13577-019-00285-x","volume":"33","author":"S Liu","year":"2020","unstructured":"Liu S, Chen Q, Wang Y (2020) MiR-125b-5p suppresses the bladder cancer progression via targeting HK2 and suppressing PI3K\/AKT pathway. Hum Cell 33(1):185\u2013194","journal-title":"Hum Cell"},{"key":"1171_CR39","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.cellsig.2019.03.011","volume":"58","author":"H Li","year":"2019","unstructured":"Li H, Lu S, Chen Y, Zheng L, Chen L, Ding H, Ding J, Lou D, Liu F, Zheng B (2019) AKT2 phosphorylation of hexokinase 2 at T473 promotes tumorigenesis and metastasis in colon cancer cells via NF-\u03baB, HIF1\u03b1, MMP2, and MMP9 upregulation. Cell Signal 58:99\u2013110","journal-title":"Cell Signal"},{"key":"1171_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2024.107097","volume":"201","author":"Z Wu","year":"2024","unstructured":"Wu Z, Zhang W, Chen L, Wang T, Wang X, Shi H, Zhang L, Zhong M, Shi X, Mao X (2024) CDK12 inhibition upregulates ATG7 triggering autophagy via AKT\/FOXO3 pathway and enhances anti-PD-1 efficacy in colorectal cancer. Pharmacol Res 201:107097","journal-title":"Pharmacol Res"},{"issue":"7448","key":"1171_CR41","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1038\/nature12122","volume":"497","author":"H Yang","year":"2013","unstructured":"Yang H, Rudge DG, Koos JD, Vaidialingam B, Yang HJ, Pavletich NP (2013) mTOR kinase structure, mechanism and regulation. Nature 497(7448):217\u2013223","journal-title":"Nature"},{"issue":"11","key":"1171_CR42","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1158\/2159-8290.CD-15-0460","volume":"5","author":"P Liu","year":"2015","unstructured":"Liu P, Gan W, Chin YR, Ogura K, Guo J, Zhang J, Wang B, Blenis J, Cantley LC, Toker A (2015) PtdIns (3, 4, 5) P 3-dependent activation of the mTORC2 kinase complex. Cancer Discov 5(11):1194\u20131209","journal-title":"Cancer Discov"},{"issue":"2","key":"1171_CR43","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.cell.2012.03.017","volume":"149","author":"M Laplante","year":"2012","unstructured":"Laplante M, Sabatini DM (2012) mTOR signaling in growth control and disease. Cell 149(2):274\u2013293","journal-title":"Cell"},{"issue":"3","key":"1171_CR44","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1038\/s41419-024-06607-8","volume":"15","author":"Z-H Wu","year":"2024","unstructured":"Wu Z-H, Wang Y-X, Song J-J, Zhao L-Q, Zhai Y-J, Liu Y-F, Guo W-J (2024) LncRNA SNHG26 promotes gastric cancer progression and metastasis by inducing c-Myc protein translation and an energy metabolism positive feedback loop. Cell Death Dis 15(3):236","journal-title":"Cell Death Dis"},{"issue":"2","key":"1171_CR45","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1111\/bjh.18187","volume":"198","author":"S Stengel","year":"2022","unstructured":"Stengel S, Petrie KR, Sbirkov Y, Stanko C, Ghazvini Zadegan F, Gil V, Skopek R, Kami\u0144ski P, Szyma\u0144ski \u0141, Brioli A (2022) Suppression of MYC by PI3K\/AKT\/mTOR pathway inhibition in combination with all-trans retinoic acid treatment for therapeutic gain in acute myeloid leukaemia. Br J Haematol 198(2):338\u2013348","journal-title":"Br J Haematol"},{"issue":"6","key":"1171_CR46","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.21037\/jgo-20-474","volume":"11","author":"G Cui","year":"2020","unstructured":"Cui G, Huang Y, Feng W, Yao Y, Zhou H, Li X, Gong H, Liu J, Luo Y, Sun Y (2020) Colon cancer-associated transcript-1 enhances glucose metabolism and colon cancer cell activity in a high-glucose environment in vitro and in vivo. J Gastrointest Oncol 11(6):1164","journal-title":"J Gastrointest Oncol"},{"issue":"1","key":"1171_CR47","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12298-z","volume":"10","author":"DP Labb\u00e9","year":"2019","unstructured":"Labb\u00e9 DP, Zadra G, Yang M, Reyes JM, Lin CY, Cacciatore S, Ebot EM, Creech AL, Giunchi F, Fiorentino M (2019) High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program. Nat Commun 10(1):4358","journal-title":"Nat Commun"},{"issue":"9","key":"1171_CR48","doi-asserted-by":"publisher","first-page":"2371","DOI":"10.3390\/cells10092371","volume":"10","author":"S-H Lee","year":"2021","unstructured":"Lee S-H, Golinska M, Griffiths JR (2021) HIF-1-independent mechanisms regulating metabolic adaptation in hypoxic cancer cells. Cells 10(9):2371","journal-title":"Cells"},{"issue":"2","key":"1171_CR49","doi-asserted-by":"publisher","first-page":"1886","DOI":"10.3390\/ijms13021886","volume":"13","author":"H P\u00f3pulo","year":"2012","unstructured":"P\u00f3pulo H, Lopes JM, Soares P (2012) The mTOR signalling pathway in human cancer. Int J Mol Sci 13(2):1886\u20131918","journal-title":"Int J Mol Sci"},{"issue":"3191","key":"1171_CR50","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1126\/science.123.3191.309","volume":"123","author":"O Warburg","year":"1956","unstructured":"Warburg O (1956) On the origin of cancer cells. Science 123(3191):309\u2013314","journal-title":"Science"},{"issue":"2","key":"1171_CR51","first-page":"164","volume":"17","author":"L Schwartz","year":"2017","unstructured":"Schwartz L, Supuran CT, Alfarouk KO (2017) The Warburg effect and the hallmarks of cancer. Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents) 17(2):164\u2013170","journal-title":"Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents)"},{"issue":"8","key":"1171_CR52","doi-asserted-by":"publisher","first-page":"3113","DOI":"10.7150\/ijbs.89942","volume":"20","author":"F Fontana","year":"2024","unstructured":"Fontana F, Giannitti G, Marchesi S, Limonta P (2024) The PI3K\/Akt pathway and glucose metabolism: a dangerous liaison in cancer. Int J Biol Sci 20(8):3113","journal-title":"Int J Biol Sci"},{"issue":"46","key":"1171_CR53","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abo1673","volume":"8","author":"W Wang","year":"2022","unstructured":"Wang W, Hapach LA, Griggs L, Smart K, Wu Y, Taufalele PV, Rowe MM, Young KM, Bates ME, Johnson AC (2022) Diabetic hyperglycemia promotes primary tumor progression through glycation-induced tumor extracellular matrix stiffening. Sci Adv 8(46):eabo1673","journal-title":"Sci Adv"},{"issue":"1","key":"1171_CR54","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-49199-9","volume":"15","author":"H-J Jang","year":"2024","unstructured":"Jang H-J, Min H-Y, Kang YP, Boo H-J, Kim J, Ahn JH, Oh SH, Jung JH, Park C-S, Park J-S (2024) Tobacco-induced hyperglycemia promotes lung cancer progression via cancer cell-macrophage interaction through paracrine IGF2\/IR\/NPM1-driven PD-L1 expression. Nat Commun 15(1):4909","journal-title":"Nat Commun"},{"key":"1171_CR55","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.106039","volume":"175","author":"R Benedetti","year":"2022","unstructured":"Benedetti R, Benincasa G, Glass K, Chianese U, Vietri MT, Congi R, Altucci L, Napoli C (2022) Effects of novel SGLT2 inhibitors on cancer incidence in hyperglycemic patients: a meta-analysis of randomized clinical trials. Pharmacol Res 175:106039","journal-title":"Pharmacol Res"},{"issue":"5","key":"1171_CR56","doi-asserted-by":"publisher","DOI":"10.62347\/NYHH3132","volume":"16","author":"H Zhao","year":"2024","unstructured":"Zhao H, Wu K (2024) Effect of hyperglycemia on the occurrence and prognosis of colorectal cancer. Am J Transl Res 16(5):2070","journal-title":"Am J Transl Res"},{"issue":"11","key":"1171_CR57","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0079708","volume":"8","author":"R Lopez","year":"2013","unstructured":"Lopez R, Arumugam A, Joseph R, Monga K, Boopalan T, Agullo P, Gutierrez C, Nandy S, Subramani R, de la Rosa JM (2013) Hyperglycemia enhances the proliferation of non-tumorigenic and malignant mammary epithelial cells through increased leptin\/IGF1R signaling and activation of AKT\/mTOR. PLoS One 8(11):e79708","journal-title":"PLoS One"},{"issue":"5","key":"1171_CR58","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1016\/j.jcmgh.2022.07.008","volume":"14","author":"S Wu","year":"2022","unstructured":"Wu S, Zhang H, Gao C, Chen J, Li H, Meng Z, Bai J, Shen Q, Wu H, Yin T (2022) Hyperglycemia enhances immunosuppression and aerobic glycolysis of pancreatic cancer through upregulating Bmi1-UPF1-HK2 pathway. Cell Mol Gastroenterol Hepatol 14(5):1146\u20131165","journal-title":"Cell Mol Gastroenterol Hepatol"},{"issue":"11","key":"1171_CR59","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.7382","volume":"13","author":"F Li","year":"2024","unstructured":"Li F, Wan X, Li Z, Zhou L (2024) High glucose inhibits autophagy and promotes the proliferation and metastasis of colorectal cancer through the PI3K\/AKT\/mTOR pathway. Cancer Med 13(11):e7382","journal-title":"Cancer Med"},{"issue":"11","key":"1171_CR60","doi-asserted-by":"publisher","first-page":"3803","DOI":"10.1007\/s00262-023-03533-0","volume":"72","author":"E Vita","year":"2023","unstructured":"Vita E, Stefani A, Piro G, Mastrantoni L, Cintoni M, Cicchetti G, Sparagna I, Monaca F, Horn G, Russo J (2023) Leptin-mediated meta-inflammation may provide survival benefit in patients receiving maintenance immunotherapy for extensive-stage small cell lung cancer (ES-SCLC). Cancer Immunol Immunother 72(11):3803\u20133812","journal-title":"Cancer Immunol Immunother"},{"key":"1171_CR61","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2024.1396022","volume":"15","author":"Y-Y Zhang","year":"2024","unstructured":"Zhang Y-Y, Li Y-J, Xue C-D, Li S, Gao Z-N, Qin K-R (2024) Effects of T2DM on cancer progression: pivotal precipitating factors and underlying mechanisms. Front Endocrinol 15:1396022","journal-title":"Front Endocrinol"},{"issue":"1","key":"1171_CR62","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/6917206","volume":"2018","author":"J Luo","year":"2018","unstructured":"Luo J, Xiang Y, Xu X, Fang D, Li D, Ni F, Zhu X, Chen B, Zhou M (2018) High glucose-induced ROS production stimulates proliferation of pancreatic cancer via inactivating the JNK pathway. Oxid Med Cell Longev 2018(1):6917206","journal-title":"Oxid Med Cell Longev"},{"key":"1171_CR63","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1007\/s11010-020-03928-y","volume":"476","author":"BN Waghela","year":"2021","unstructured":"Waghela BN, Vaidya FU, Ranjan K, Chhipa AS, Tiwari BS, Pathak C (2021) AGE-RAGE synergy influences programmed cell death signaling to promote cancer. Mol Cell Biochem 476:585\u2013598","journal-title":"Mol Cell Biochem"},{"issue":"5","key":"1171_CR64","first-page":"1741","volume":"5","author":"J-M Bao","year":"2015","unstructured":"Bao J-M, He M-Y, Liu Y-W, Lu Y-J, Hong Y-Q, Luo H-H, Ren Z-L, Zhao S-C, Jiang Y (2015) AGE\/RAGE\/Akt pathway contributes to prostate cancer cell proliferation by promoting Rb phosphorylation and degradation. Am J Cancer Res 5(5):1741","journal-title":"Am J Cancer Res"},{"issue":"61","key":"1171_CR65","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.22185","volume":"8","author":"R Deng","year":"2017","unstructured":"Deng R, Mo F, Chang B, Zhang Q, Ran H, Yang S, Zhu Z, Hu L, Su Q (2017) Glucose-derived AGEs enhance human gastric cancer metastasis through RAGE\/ERK\/Sp1\/MMP2 cascade. Oncotarget 8(61):104216","journal-title":"Oncotarget"},{"issue":"24","key":"1171_CR66","doi-asserted-by":"publisher","first-page":"7285","DOI":"10.1158\/0008-5472.CAN-14-1240","volume":"74","author":"X Chen","year":"2014","unstructured":"Chen X, Zhang L, Zhang IY, Liang J, Wang H, Ouyang M, Wu S, da Fonseca ACC, Weng L, Yamamoto Y (2014) RAGE expression in tumor-associated macrophages promotes angiogenesis in glioma. Cancer Res 74(24):7285\u20137297","journal-title":"Cancer Res"},{"issue":"15","key":"1171_CR67","doi-asserted-by":"publisher","DOI":"10.3390\/cells11152402","volume":"11","author":"MF Santolla","year":"2022","unstructured":"Santolla MF, Talia M, Cirillo F, Scordamaglia D, De Rosis S, Spinelli A, Miglietta AM, Nardo B, Filippelli G, De Francesco EM (2022) The AGEs\/RAGE transduction signaling prompts IL-8\/CXCR1\/2-mediated interaction between cancer-associated fibroblasts (CAFs) and breast cancer cells. Cells 11(15):2402","journal-title":"Cells"},{"key":"1171_CR68","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S240378","author":"R Li","year":"2020","unstructured":"Li R, Song Y, Zhou L, Li W, Zhu X (2020) Downregulation of RAGE inhibits cell proliferation and induces apoptosis via regulation of PI3K\/AKT pathway in cervical squamous cell carcinoma. Onco Targets Ther. https:\/\/doi.org\/10.2147\/OTT.S240378","journal-title":"Onco Targets Ther"},{"issue":"11","key":"1171_CR69","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1038\/onc.2016.324","volume":"36","author":"T Kwak","year":"2017","unstructured":"Kwak T, Drews-Elger K, Ergonul A, Miller P, Braley A, Hwang G, Zhao D, Besser A, Yamamoto Y, Yamamoto H (2017) Targeting of RAGE-ligand signaling impairs breast cancer cell invasion and metastasis. Oncogene 36(11):1559\u20131572","journal-title":"Oncogene"},{"issue":"3","key":"1171_CR70","doi-asserted-by":"publisher","first-page":"285","DOI":"10.4093\/dmj.2020.0250","volume":"45","author":"AM Zhang","year":"2021","unstructured":"Zhang AM, Wellberg EA, Kopp JL, Johnson JD (2021) Hyperinsulinemia in obesity, inflammation, and cancer. Diabetes Metab J 45(3):285\u2013311","journal-title":"Diabetes Metab J"},{"key":"1171_CR71","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13072-019-0290-9","volume":"12","author":"P Senapati","year":"2019","unstructured":"Senapati P, Kato H, Lee M, Leung A, Thai C, Sanchez A, Gallagher EJ, LeRoith D, Seewaldt VL, Ann DK (2019) Hyperinsulinemia promotes aberrant histone acetylation in triple-negative breast cancer. Epigenetics Chromatin 12:1\u201315","journal-title":"Epigenetics Chromatin"},{"issue":"6","key":"1171_CR72","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1038\/s41556-022-00919-7","volume":"24","author":"M Cao","year":"2022","unstructured":"Cao M, Isaac R, Yan W, Ruan X, Jiang L, Wan Y, Wang J, Wang E, Caron C, Neben S (2022) Cancer-cell-secreted extracellular vesicles suppress insulin secretion through miR-122 to impair systemic glucose homeostasis and contribute to tumour growth. Nat Cell Biol 24(6):954\u2013967","journal-title":"Nat Cell Biol"},{"issue":"5","key":"1171_CR73","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3892\/ol.2020.12069","volume":"20","author":"H-Y Chiu","year":"2020","unstructured":"Chiu H-Y, Chiang C-M, Yeh S-P, Jong D-S, Wu L-S, Liu H-C, Chiu C-H (2020) Effects of hyperinsulinemia on acquired resistance to epidermal growth factor receptor\u2013tyrosine kinase inhibitor via the PI3K\/AKT pathway in non\u2013small cell lung cancer cells in vitro. Oncol Lett 20(5):1\u20131","journal-title":"Oncol Lett"},{"key":"1171_CR74","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/bcr2927","volume":"13","author":"EJ Kim","year":"2011","unstructured":"Kim EJ, Choi M-R, Park H, Kim M, Hong JE, Lee J-Y, Chun HS, Lee KW, Yoon Park JH (2011) Dietary fat increases solid tumor growth and metastasis of 4T1 murine mammary carcinoma cells and mortality in obesity-resistant BALB\/c mice. Breast Cancer Res 13:1\u201313","journal-title":"Breast Cancer Res"},{"issue":"11","key":"1171_CR75","doi-asserted-by":"publisher","first-page":"3130","DOI":"10.1158\/0008-5472.CAN-15-1501","volume":"76","author":"DP Labb\u00e9","year":"2016","unstructured":"Labb\u00e9 DP, Uetani N, Vinette V, Lessard L, Aubry I, Migon E, Sirois J, Haigh JJ, B\u00e9gin LR, Trotman LC (2016) PTP1B deficiency enables the ability of a high-fat diet to drive the invasive character of PTEN-deficient prostate cancers. Cancer Res 76(11):3130\u20133135","journal-title":"Cancer Res"},{"issue":"3","key":"1171_CR76","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.molmet.2014.12.011","volume":"4","author":"J Liu","year":"2015","unstructured":"Liu J, Ramakrishnan SK, Khuder SS, Kaw MK, Muturi HT, Lester SG, Lee SJ, Fedorova LV, Kim AJ, Mohamed IE (2015) High-calorie diet exacerbates prostate neoplasia in mice with haploinsufficiency of Pten tumor suppressor gene. Mol Metab 4(3):186\u2013198","journal-title":"Mol Metab"},{"issue":"2","key":"1171_CR77","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1158\/2326-6066.CIR-20-0358","volume":"9","author":"N Khojandi","year":"2021","unstructured":"Khojandi N, Kuehm LM, Piening A, Donlin MJ, Hsueh EC, Schwartz TL, Farrell K, Richart JM, Geerling E, Pinto AK (2021) Oxidized lipoproteins promote resistance to cancer immunotherapy independent of patient obesity. Cancer Immunol Res 9(2):214\u2013226","journal-title":"Cancer Immunol Res"},{"key":"1171_CR78","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.803473","volume":"12","author":"C-F Deng","year":"2022","unstructured":"Deng C-F, Zhu N, Zhao T-J, Li H-F, Gu J, Liao D-F, Qin L (2022) Involvement of LDL and ox-LDL in cancer development and its therapeutical potential. Front Oncol 12:803473","journal-title":"Front Oncol"},{"issue":"9","key":"1171_CR79","doi-asserted-by":"publisher","first-page":"3887","DOI":"10.18632\/aging.204051","volume":"14","author":"D Sun","year":"2022","unstructured":"Sun D, Zhang M, Wei M, Wang Z, Qiao W, Liu P, Zhong X, Liang Y, Chen Y, Huang Y (2022) Ox-LDL-mediated ILF3 overexpression in gastric cancer progression by activating the PI3K\/AKT\/mTOR signaling pathway. Aging 14(9):3887","journal-title":"Aging"},{"issue":"11","key":"1171_CR80","doi-asserted-by":"publisher","first-page":"1834","DOI":"10.1158\/0008-5472.CAN-23-0519","volume":"84","author":"N Boufaied","year":"2024","unstructured":"Boufaied N, Chetta P, Hallal T, Cacciatore S, Lalli D, Luthold C, Homsy K, Imada EL, Syamala S, Photopoulos C (2024) Obesogenic high-fat diet and MYC cooperate to promote lactate accumulation and tumor microenvironment remodeling in prostate cancer. Cancer Res 84(11):1834\u20131855","journal-title":"Cancer Res"},{"issue":"5","key":"1171_CR81","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1038\/s41574-020-0329-9","volume":"16","author":"BD Hopkins","year":"2020","unstructured":"Hopkins BD, Goncalves MD, Cantley LC (2020) Insulin\u2013PI3K signalling: an evolutionarily insulated metabolic driver of cancer. Nat Rev Endocrinol 16(5):276\u2013283","journal-title":"Nat Rev Endocrinol"},{"issue":"2","key":"1171_CR82","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.trecan.2019.12.003","volume":"6","author":"RJ Perry","year":"2020","unstructured":"Perry RJ, Shulman GI (2020) Mechanistic links between obesity, insulin, and cancer. Trends Cancer 6(2):75\u201378","journal-title":"Trends Cancer"},{"issue":"613","key":"1171_CR83","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aay2940","volume":"13","author":"RR Madsen","year":"2020","unstructured":"Madsen RR, Vanhaesebroeck B (2020) Cracking the context-specific PI3K signaling code. Sci Signal 13(613):eaay2940","journal-title":"Sci Signal"},{"issue":"3","key":"1171_CR84","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1016\/j.ygyno.2012.03.012","volume":"125","author":"Y Wang","year":"2012","unstructured":"Wang Y, Hua S, Tian W, Zhang L, Zhao J, Zhang H, Zhang W, Xue F (2012) Mitogenic and anti-apoptotic effects of insulin in endometrial cancer are phosphatidylinositol 3-kinase\/Akt dependent. Gynecol Oncol 125(3):734\u2013741","journal-title":"Gynecol Oncol"},{"issue":"8","key":"1171_CR85","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1038\/s41422-020-0343-4","volume":"30","author":"X He","year":"2020","unstructured":"He X, Xu C (2020) Immune checkpoint signaling and cancer immunotherapy. Cell Res 30(8):660\u2013669","journal-title":"Cell Res"},{"key":"1171_CR86","doi-asserted-by":"publisher","DOI":"10.21037\/aob-21-3","author":"S Peng","year":"2022","unstructured":"Peng S, Bao Y (2022) A narrative review of immune checkpoint mechanisms and current immune checkpoint therapy. Ann Blood. https:\/\/doi.org\/10.21037\/aob-21-3","journal-title":"Ann Blood"},{"key":"1171_CR87","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.imlet.2017.02.006","volume":"184","author":"X Wang","year":"2017","unstructured":"Wang X, Yang L, Huang F, Zhang Q, Liu S, Ma L, You Z (2017) Inflammatory cytokines IL-17 and TNF-\u03b1 up-regulate PD-L1 expression in human prostate and colon cancer cells. Immunol Lett 184:7\u201314","journal-title":"Immunol Lett"},{"issue":"1","key":"1171_CR88","first-page":"74","volume":"6","author":"M Mohammadi","year":"2017","unstructured":"Mohammadi M, Gozashti MH, Aghadavood M, Mehdizadeh MR, Hayatbakhsh MM (2017) Clinical significance of serum IL-6 and TNF-\u03b1 levels in patients with metabolic syndrome. Rep Biochem Mol biology 6(1):74","journal-title":"Rep Biochem Mol biology"},{"key":"1171_CR89","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12943-018-0928-4","volume":"18","author":"X Jiang","year":"2019","unstructured":"Jiang X, Wang J, Deng X, Xiong F, Ge J, Xiang B, Wu X, Ma J, Zhou M, Li X (2019) Role of the tumor microenvironment in PD-L1\/PD-1-mediated tumor immune escape. Mol Cancer 18:1\u201317","journal-title":"Mol Cancer"},{"issue":"6","key":"1171_CR90","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1016\/j.cell.2015.08.016","volume":"162","author":"C-H Chang","year":"2015","unstructured":"Chang C-H, Qiu J, O\u2019Sullivan D, Buck MD, Noguchi T, Curtis JD, Chen Q, Gindin M, Gubin MM, Van Der Windt GJ (2015) Metabolic competition in the tumor microenvironment is a driver of cancer progression. Cell 162(6):1229\u20131241","journal-title":"Cell"},{"key":"1171_CR91","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1034205","volume":"13","author":"L Singh","year":"2023","unstructured":"Singh L, Nair L, Kumar D, Arora MK, Bajaj S, Gadewar M, Mishra SS, Rath SK, Dubey AK, Kaithwas G (2023) Hypoxia induced lactate acidosis modulates tumor microenvironment and lipid reprogramming to sustain the cancer cell survival. Front Oncol 13:1034205","journal-title":"Front Oncol"},{"issue":"1","key":"1171_CR92","first-page":"1","volume":"23","author":"MA Andrea","year":"2023","unstructured":"Andrea MA (2023) Metabolic challenges in anticancer CD8 T cell functions. Immune Netw 23(1):1\u201315","journal-title":"Immune Netw"},{"key":"1171_CR93","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1007\/s00262-019-02457-y","volume":"69","author":"X Li","year":"2020","unstructured":"Li X, Zhang Y, Ma W, Fu Q, Liu J, Yin G, Chen P, Dai D, Chen W, Qi L (2020) Enhanced glucose metabolism mediated by CD147 contributes to immunosuppression in hepatocellular carcinoma. Cancer Immunol Immunother 69:535\u2013548","journal-title":"Cancer Immunol Immunother"},{"issue":"1","key":"1171_CR94","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01332-8","volume":"8","author":"Z Chen","year":"2023","unstructured":"Chen Z, Han F, Du Y, Shi H, Zhou W (2023) Hypoxic microenvironment in cancer: molecular mechanisms and therapeutic interventions. Signal Transduct Target Ther 8(1):70","journal-title":"Signal Transduct Target Ther"},{"issue":"15","key":"1171_CR95","doi-asserted-by":"publisher","first-page":"8231","DOI":"10.3390\/ijms23158231","volume":"23","author":"J Xu","year":"2022","unstructured":"Xu J, Li L, Shi P, Cui H, Yang L (2022) The crucial roles of Bmi-1 in cancer: implications in pathogenesis, metastasis, drug resistance, and targeted therapies. Int J Mol Sci 23(15):8231","journal-title":"Int J Mol Sci"},{"issue":"10","key":"1171_CR96","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1158\/2326-6066.CIR-19-0904","volume":"8","author":"N Rodrigues Mantuano","year":"2020","unstructured":"Rodrigues Mantuano N, Stanczak MA, Oliveira I, Kirchhammer N, Filardy AA, Monaco G, Santos RC, Fonseca AC, Fontes M, Bastos C Jr (2020) Hyperglycemia enhances cancer immune evasion by inducing alternative macrophage polarization through increased O-GlcNAcylation. Cancer Immunol Res 8(10):1262\u20131272","journal-title":"Cancer Immunol Res"},{"key":"1171_CR97","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2024.217091","volume":"598","author":"E Richiardone","year":"2024","unstructured":"Richiardone E, Al Roumi R, Lardinois F, Giolito MV, Ambroise J, Boidot R, Drotleff B, Ghesqui\u00e8re B, Bellahc\u00e8ne A, Bardelli A (2024) MCT1-dependent lactate recycling is a metabolic vulnerability in colorectal cancer cells upon acquired resistance to anti-EGFR targeted therapy. Cancer Lett 598:217091","journal-title":"Cancer Lett"},{"key":"1171_CR98","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2020-000964","author":"B Wu","year":"2020","unstructured":"Wu B, Chiang H-C, Sun X, Yuan B, Mitra P, Hu Y, Curiel TJ, Li R (2020) Genetic ablation of adipocyte PD-L1 reduces tumor growth but accentuates obesity-associated inflammation. J Immunother Cancer. https:\/\/doi.org\/10.1136\/jitc-2020-000964","journal-title":"J Immunother Cancer"},{"key":"1171_CR99","first-page":"1","volume":"20","author":"Z Li","year":"2020","unstructured":"Li Z, Zhang C, Du J-X, Zhao J, Shi M-T, Jin M-W, Liu H (2020) Adipocytes promote tumor progression and induce PD-L1 expression via TNF-\u03b1\/IL-6 signaling. Cancer Cell Int 20:1\u20139","journal-title":"Cancer Cell Int"},{"issue":"7","key":"1171_CR100","doi-asserted-by":"publisher","first-page":"1848","DOI":"10.1016\/j.cell.2020.11.009","volume":"183","author":"AE Ringel","year":"2020","unstructured":"Ringel AE, Drijvers JM, Baker GJ, Catozzi A, Garc\u00eda-Ca\u00f1averas JC, Gassaway BM, Miller BC, Juneja VR, Nguyen TH, Joshi S (2020) Obesity shapes metabolism in the tumor microenvironment to suppress anti-tumor immunity. Cell 183(7):1848-1866. e26","journal-title":"Cell"},{"issue":"1","key":"1171_CR101","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1038\/s41591-018-0221-5","volume":"25","author":"Z Wang","year":"2019","unstructured":"Wang Z, Aguilar EG, Luna JI, Dunai C, Khuat LT, Le CT, Mirsoian A, Minnar CM, Stoffel KM, Sturgill IR (2019) Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade. Nat Med 25(1):141\u2013151","journal-title":"Nat Med"},{"key":"1171_CR102","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2022.215918","volume":"550","author":"C Zhang","year":"2022","unstructured":"Zhang C, Zhou L, Li S, Zhao J, Meng X, Ma L, Wang Y, Li C, Zheng L, Ming L (2022) Obesity accelerates immune evasion of non-small cell lung carcinoma via TFEB-dependent upregulation of Siglec-15 and glycolytic reprogramming. Cancer Lett 550:215918","journal-title":"Cancer Lett"},{"issue":"3","key":"1171_CR103","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.4049\/jimmunol.1100587","volume":"189","author":"BR James","year":"2012","unstructured":"James BR, Tomanek-Chalkley A, Askeland EJ, Kucaba T, Griffith TS, Norian LA (2012) Diet-induced obesity alters dendritic cell function in the presence and absence of tumor growth. J Immunol 189(3):1311\u20131321","journal-title":"J Immunol"},{"key":"1171_CR104","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109285","author":"AK Pingili","year":"2021","unstructured":"Pingili AK, Chaib M, Sipe LM, Miller EJ, Teng B, Sharma R, Yarbro JR, Asemota S, Al Abdallah Q, Mims TS (2021) Immune checkpoint blockade reprograms systemic immune landscape and tumor microenvironment in obesity-associated breast cancer. Cell Rep. https:\/\/doi.org\/10.1016\/j.celrep.2021.109285","journal-title":"Cell Rep"},{"issue":"1","key":"1171_CR105","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-13855-1","volume":"12","author":"Y Liang","year":"2022","unstructured":"Liang Y, Wang W, Zhu X, Yu M, Zhou C (2022) Inhibition of myeloid-derived suppressive cell function with all-trans retinoic acid enhanced anti-PD-L1 efficacy in cervical cancer. Sci Rep 12(1):9619","journal-title":"Sci Rep"},{"issue":"1","key":"1171_CR106","doi-asserted-by":"publisher","first-page":"264","DOI":"10.4049\/jimmunol.1800129","volume":"201","author":"W Xiao","year":"2018","unstructured":"Xiao W, Klement JD, Lu C, Ibrahim ML, Liu K (2018) IFNAR1 controls autocrine type I IFN regulation of PD-L1 expression in myeloid-derived suppressor cells. J Immunol 201(1):264\u2013277","journal-title":"J Immunol"},{"key":"1171_CR107","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.590794","volume":"11","author":"JT Gibson","year":"2020","unstructured":"Gibson JT, Orlandella RM, Turbitt WJ, Behring M, Manne U, Sorge RE, Norian LA (2020) Obesity-associated myeloid-derived suppressor cells promote apoptosis of tumor-infiltrating CD8 T cells and immunotherapy resistance in breast cancer. Front Immunol 11:590794","journal-title":"Front Immunol"},{"issue":"3","key":"1171_CR108","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0118784","volume":"10","author":"M Hale","year":"2015","unstructured":"Hale M, Itani F, Buchta CM, Wald G, Bing M, Norian LA (2015) Obesity triggers enhanced MDSC accumulation in murine renal tumors via elevated local production of CCL2. PLoS One 10(3):e0118784","journal-title":"PLoS One"},{"issue":"3","key":"1171_CR109","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1002\/JLB.4HI0517-210R","volume":"103","author":"VK Clements","year":"2018","unstructured":"Clements VK, Long T, Long R, Figley C, Smith DM, Ostrand-Rosenberg S (2018) Frontline science: high fat diet and leptin promote tumor progression by inducing myeloid-derived suppressor cells. J Leukoc Biol 103(3):395\u2013407","journal-title":"J Leukoc Biol"},{"issue":"1","key":"1171_CR110","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.cmet.2019.04.002","volume":"30","author":"X Ma","year":"2019","unstructured":"Ma X, Bi E, Lu Y, Su P, Huang C, Liu L, Wang Q, Yang M, Kalady MF, Qian J (2019) Cholesterol induces CD8\u2009+\u2009T cell exhaustion in the tumor microenvironment. Cell Metab 30(1):143\u2013156","journal-title":"Cell Metab"},{"issue":"6","key":"1171_CR111","doi-asserted-by":"publisher","first-page":"1376","DOI":"10.1016\/j.cmet.2019.02.016","volume":"29","author":"P Goossens","year":"2019","unstructured":"Goossens P, Rodriguez-Vita J, Etzerodt A, Masse M, Rastoin O, Gouirand V, Ulas T, Papantonopoulou O, Van Eck M, Auphan-Anezin N (2019) Membrane cholesterol efflux drives tumor-associated macrophage reprogramming and tumor progression. Cell Metab 29(6):1376-1389. e4","journal-title":"Cell Metab"},{"issue":"4","key":"1171_CR112","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1158\/2326-6066.CIR-17-0327","volume":"6","author":"NV Rodrigues","year":"2018","unstructured":"Rodrigues NV, Correia DV, Mensurado S, N\u00f3brega-Pereira S, Debarros A, Kyle-Cezar F, Tutt A, Hayday AC, Norell H, Silva-Santos B (2018) Low-density lipoprotein uptake inhibits the activation and antitumor functions of human V\u03b39V\u03b42 T cells. Cancer Immunol Res 6(4):448\u2013457","journal-title":"Cancer Immunol Res"},{"issue":"4","key":"1171_CR113","doi-asserted-by":"publisher","DOI":"10.1002\/iid3.70196","volume":"13","author":"E Rezazadeh-Gavgani","year":"2025","unstructured":"Rezazadeh-Gavgani E, Majidazar R, Lotfinejad P, Kazemi T, Shamekh A (2025) Immune checkpoint molecules: a review on pathways and immunotherapy implications. Immun Inflamm Dis 13(4):e70196","journal-title":"Immun Inflamm Dis"},{"key":"1171_CR114","first-page":"156","volume-title":"Precision Cancer Therapies vol 2-Immunologic Approaches for the Treatment of Lymphoid Malignancies\u2010From Concept to Practice","author":"CM Csizmar","year":"2024","unstructured":"Csizmar CM, Ansell SM (2024) Other Immune Checkpoint Targets of Interest. Precision Cancer Therapies vol 2-Immunologic Approaches for the Treatment of Lymphoid Malignancies\u2010From Concept to Practice. pp 156\u2013189"},{"issue":"1","key":"1171_CR115","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-019-1091-2","volume":"18","author":"S Qin","year":"2019","unstructured":"Qin S, Xu L, Yi M, Yu S, Wu K, Luo S (2019) Novel immune checkpoint targets: moving beyond PD-1 and CTLA-4. Mol Cancer 18(1):155","journal-title":"Mol Cancer"},{"key":"1171_CR116","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.canlet.2019.05.021","volume":"458","author":"A Lequeux","year":"2019","unstructured":"Lequeux A, Noman MZ, Xiao M, Sauvage D, Van Moer K, Viry E, Bocci I, Hasmim M, Bosseler M, Berchem G (2019) Impact of hypoxic tumor microenvironment and tumor cell plasticity on the expression of immune checkpoints. Cancer Lett 458:13\u201320","journal-title":"Cancer Lett"},{"key":"1171_CR117","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.11306","volume":"9","author":"M Hu","year":"2021","unstructured":"Hu M, Li Y, Lu Y, Wang M, Li Y, Wang C, Li Q, Zhao H (2021) The regulation of immune checkpoints by the hypoxic tumor microenvironment. PeerJ 9:e11306","journal-title":"PeerJ"},{"issue":"5","key":"1171_CR118","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2022-005719","volume":"11","author":"V Finisguerra","year":"2023","unstructured":"Finisguerra V, Dvorakova T, Formenti M, Van Meerbeeck P, Mignion L, Gallez B, den Van Eynde BJ (2023) Metformin improves cancer immunotherapy by directly rescuing tumor-infiltrating CD8 T lymphocytes from hypoxia-induced immunosuppression. J Immunother Cancer 11(5):e005719","journal-title":"J Immunother Cancer"},{"issue":"11","key":"1171_CR119","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1038\/ni.2714","volume":"14","author":"AL Doedens","year":"2013","unstructured":"Doedens AL, Phan AT, Stradner MH, Fujimoto JK, Nguyen JV, Yang E, Johnson RS, Goldrath AW (2013) Hypoxia-inducible factors enhance the effector responses of CD8\u2009+\u2009T cells to persistent antigen. Nat Immunol 14(11):1173\u20131182","journal-title":"Nat Immunol"},{"issue":"16","key":"1171_CR120","doi-asserted-by":"publisher","first-page":"4355","DOI":"10.1016\/j.cell.2024.07.016","volume":"187","author":"LP Andrews","year":"2024","unstructured":"Andrews LP, Butler SC, Cui J, Cillo AR, Cardello C, Liu C, Brunazzi EA, Baessler A, Xie B, Kunning SR (2024) LAG-3 and PD-1 synergize on CD8\u2009+\u2009T cells to drive T cell exhaustion and hinder autocrine IFN-\u03b3-dependent anti-tumor immunity. Cell 187(16):4355-4372. e22","journal-title":"Cell"},{"issue":"37","key":"1171_CR121","doi-asserted-by":"publisher","first-page":"61425","DOI":"10.18632\/oncotarget.18251","volume":"8","author":"Z-Z Yang","year":"2017","unstructured":"Yang Z-Z, Kim HJ, Villasboas JC, Chen Y-P, Price-Troska T, Jalali S, Wilson M, Novak AJ, Ansell SM (2017) Expression of LAG-3 defines exhaustion of intratumoral PD-1\u2009+\u2009T cells and correlates with poor outcome in follicular lymphoma. Oncotarget 8(37):61425","journal-title":"Oncotarget"},{"issue":"1","key":"1171_CR122","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1056\/NEJMoa2109970","volume":"386","author":"HA Tawbi","year":"2022","unstructured":"Tawbi HA, Schadendorf D, Lipson EJ, Ascierto PA, Matamala L, Castillo Guti\u00e9rrez E, Rutkowski P, Gogas HJ, Lao CD, De Menezes JJ (2022) Relatlimab and nivolumab versus nivolumab in untreated advanced melanoma. N Engl J Med 386(1):24\u201334","journal-title":"N Engl J Med"},{"issue":"2","key":"1171_CR123","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2020-000957","volume":"8","author":"J-M Chauvin","year":"2020","unstructured":"Chauvin J-M, Zarour HM (2020) TIGIT in cancer immunotherapy. J Immunother Cancer 8(2):e000957","journal-title":"J Immunother Cancer"},{"issue":"1","key":"1171_CR124","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-023-01455-z","volume":"22","author":"M Huang","year":"2024","unstructured":"Huang M, Yu X, Wang Q, Jiang Z, Li X, Chen W, Song C (2024) The immune checkpoint TIGIT\/CD155 promotes the exhaustion of CD8\u2009+\u2009T cells in TNBC through glucose metabolic reprogramming mediated by PI3K\/AKT\/mTOR signaling. Cell Commun Signal 22(1):35","journal-title":"Cell Commun Signal"},{"key":"1171_CR125","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1060112","volume":"13","author":"N Jantz-Naeem","year":"2023","unstructured":"Jantz-Naeem N, B\u00f6ttcher-Loschinski R, Borucki K, Mitchell-Flack M, B\u00f6ttcher M, Schraven B, Mougiakakos D, Kahlfuss S (2023) TIGIT signaling and its influence on T cell metabolism and immune cell function in the tumor microenvironment. Front Oncol 13:1060112","journal-title":"Front Oncol"},{"key":"1171_CR126","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.688961","volume":"12","author":"Q Shao","year":"2021","unstructured":"Shao Q, Wang L, Yuan M, Jin X, Chen Z, Wu C (2021) TIGIT induces (CD3+) T cell dysfunction in colorectal cancer by inhibiting glucose metabolism. Front Immunol 12:688961","journal-title":"Front Immunol"},{"issue":"1","key":"1171_CR127","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s00280-023-04627-3","volume":"94","author":"N Yamamoto","year":"2024","unstructured":"Yamamoto N, Koyama T, Sato J, Yoshida T, Sudo K, Iwasa S, Kondo S, Yonemori K, Kawasaki A, Satake K (2024) Phase I study of the anti-TIGIT antibody tiragolumab in combination with atezolizumab in Japanese patients with advanced or metastatic solid tumors. Cancer Chemother Pharmacol 94(1):109\u2013115","journal-title":"Cancer Chemother Pharmacol"},{"issue":"1","key":"1171_CR128","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-023-01499-1","volume":"16","author":"L Cai","year":"2023","unstructured":"Cai L, Li Y, Tan J, Xu L, Li Y (2023) Targeting LAG-3, TIM-3, and TIGIT for cancer immunotherapy. J Hematol Oncol 16(1):101","journal-title":"J Hematol Oncol"},{"issue":"27","key":"1171_CR129","doi-asserted-by":"publisher","first-page":"1983","DOI":"10.1080\/14796694.2024.2343272","volume":"20","author":"R Shapira-Frommer","year":"2024","unstructured":"Shapira-Frommer R, Niu J, Perets R, Peters S, Shouse G, Lugowska I, Garassino MC, Sands J, Keenan T, Zhao B (2024) The KEYVIBE program: vibostolimab and pembrolizumab for the treatment of advanced malignancies. Future Oncol 20(27):1983\u20131991","journal-title":"Future Oncol"},{"key":"1171_CR130","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2024.107458","volume":"209","author":"J Zhang","year":"2024","unstructured":"Zhang J, Wang L, Guo H, Kong S, Li W, He Q, Ding L, Yang B (2024) The role of Tim-3 blockade in the tumor immune microenvironment beyond T cells. Pharmacol Res 209:107458","journal-title":"Pharmacol Res"},{"issue":"20","key":"1171_CR131","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15204943","volume":"15","author":"M Katagata","year":"2023","unstructured":"Katagata M, Okayama H, Nakajima S, Saito K, Sato T, Sakuma M, Fukai S, Endo E, Sakamoto W, Saito M (2023) TIM-3 expression and M2 polarization of macrophages in the TGF\u03b2-activated tumor microenvironment in colorectal cancer. Cancers 15(20):4943","journal-title":"Cancers"},{"issue":"1","key":"1171_CR132","volume":"2020","author":"L Sun","year":"2020","unstructured":"Sun L, Zou S, Ding S, Du X, Shen Y, Liu C, Shi B, Zhang X (2020) Circulating T cells exhibit different TIM3\/Galectin-9 expression in patients with obesity and obesity\u2010related diabetes. J Diabetes Res 2020(1):2583257","journal-title":"J Diabetes Res"},{"key":"1171_CR133","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.852436","volume":"13","author":"H Wang","year":"2022","unstructured":"Wang H, Cao K, Liu S, Xu Y, Tang L (2022) Tim-3 expression causes NK cell dysfunction in type 2 diabetes patients. Front Immunol 13:852436","journal-title":"Front Immunol"},{"issue":"7","key":"1171_CR134","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1158\/2326-6066.CIR-18-0507","volume":"7","author":"J Deng","year":"2019","unstructured":"Deng J, Li J, Sarde A, Lines JL, Lee Y-C, Qian DC, Pechenick DA, Manivanh R, Le Mercier I, Lowrey CH (2019) Hypoxia-induced VISTA promotes the suppressive function of myeloid-derived suppressor cells in the tumor microenvironment. Cancer Immunol Res 7(7):1079\u20131090","journal-title":"Cancer Immunol Res"},{"issue":"7779","key":"1171_CR135","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1038\/s41586-019-1674-5","volume":"574","author":"RJ Johnston","year":"2019","unstructured":"Johnston RJ, Su LJ, Pinckney J, Critton D, Boyer E, Krishnakumar A, Corbett M, Rankin AL, Dibella R, Campbell L (2019) VISTA is an acidic pH-selective ligand for PSGL-1. Nature 574(7779):565\u2013570","journal-title":"Nature"},{"issue":"4","key":"1171_CR136","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1016\/j.cell.2006.02.017","volume":"124","author":"RE Ley","year":"2006","unstructured":"Ley RE, Peterson DA, Gordon JI (2006) Ecological and evolutionary forces shaping microbial diversity in the human intestine. Cell 124(4):837\u2013848","journal-title":"Cell"},{"issue":"5778","key":"1171_CR137","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1126\/science.1124234","volume":"312","author":"SR Gill","year":"2006","unstructured":"Gill SR, Pop M, DeBoy RT, Eckburg PB, Turnbaugh PJ, Samuel BS, Gordon JI, Relman DA, Fraser-Liggett CM, Nelson KE (2006) Metagenomic analysis of the human distal gut microbiome. Science 312(5778):1355\u20131359","journal-title":"Science"},{"issue":"10","key":"1171_CR138","doi-asserted-by":"publisher","DOI":"10.3390\/life14101219","volume":"14","author":"KA Rumyantsev","year":"2024","unstructured":"Rumyantsev KA, Polyakova VV, Sorokina IV, Feoktistova PS, Khatkov IE, Bodunova NA, Zhukova LG (2024) The gut microbiota impacts gastrointestinal cancers through obesity, diabetes, and chronic inflammation. Life 14(10):1219","journal-title":"Life"},{"issue":"5","key":"1171_CR139","doi-asserted-by":"publisher","first-page":"99913","DOI":"10.3748\/wjg.v31.i5.99913","volume":"31","author":"JK Paul","year":"2025","unstructured":"Paul JK, Azmal M, Haque ASNB, Meem M, Talukder OF, Ghosh A (2025) Unlocking the secrets of the human gut microbiota: comprehensive review on its role in different diseases. World J Gastroenterol 31(5):99913","journal-title":"World J Gastroenterol"},{"issue":"1","key":"1171_CR140","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1053\/j.gastro.2021.08.041","volume":"162","author":"J Yang","year":"2022","unstructured":"Yang J, Wei H, Zhou Y, Szeto C-H, Li C, Lin Y, Coker OO, Lau HCH, Chan AW, Sung JJ (2022) High-fat diet promotes colorectal tumorigenesis through modulating gut microbiota and metabolites. Gastroenterology 162(1):135-149. e2","journal-title":"Gastroenterology"},{"issue":"4","key":"1171_CR141","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1038\/s41385-019-0144-6","volume":"12","author":"M Qiu","year":"2019","unstructured":"Qiu M, Huang K, Liu Y, Yang Y, Tang H, Liu X, Wang C, Chen H, Xiong Y, Zhang J (2019) Modulation of intestinal microbiota by glycyrrhizic acid prevents high-fat diet-enhanced pre-metastatic niche formation and metastasis. Mucosal Immunol 12(4):945\u2013957","journal-title":"Mucosal Immunol"},{"key":"1171_CR142","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14112573","volume":"14","author":"Y Yu","year":"2022","unstructured":"Yu Y, Cai Y, Yang B, Xie S, Shen W, Wu Y, Sui Z, Cai J, Ni C, Ye J (2022) High-fat diet enhances the liver metastasis potential of colorectal cancer through microbiota dysbiosis. Cancers 14:2573","journal-title":"Cancers"},{"issue":"11","key":"1171_CR143","doi-asserted-by":"publisher","DOI":"10.3390\/cells10113164","volume":"10","author":"IJ Malesza","year":"2021","unstructured":"Malesza IJ, Malesza M, Walkowiak J, Mussin N, Walkowiak D, Aringazina R, Bartkowiak-Wieczorek J, M\u0105dry E (2021) High-fat, western-style diet, systemic inflammation, and gut microbiota: a narrative review. Cells 10(11):3164","journal-title":"Cells"},{"issue":"12","key":"1171_CR144","doi-asserted-by":"publisher","first-page":"5889","DOI":"10.7150\/thno.56157","volume":"11","author":"Y Tong","year":"2021","unstructured":"Tong Y, Gao H, Qi Q, Liu X, Li J, Gao J, Li P, Wang Y, Du L, Wang C (2021) High fat diet, gut microbiome and gastrointestinal cancer. Theranostics 11(12):5889","journal-title":"Theranostics"},{"issue":"7","key":"1171_CR145","doi-asserted-by":"publisher","first-page":"1797","DOI":"10.1002\/ijc.31559","volume":"143","author":"GY Koh","year":"2018","unstructured":"Koh GY, Kane A, Lee K, Xu Q, Wu X, Roper J, Mason JB, Crott JW (2018) Parabacteroides distasonis attenuates toll-like receptor 4 signaling and Akt activation and blocks colon tumor formation in high\u2010fat diet\u2010fed azoxymethane\u2010treated mice. Int J Cancer 143(7):1797\u20131805","journal-title":"Int J Cancer"},{"issue":"1","key":"1171_CR146","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.joim.2020.11.001","volume":"19","author":"L-q Zhu","year":"2021","unstructured":"Zhu L-q, Zhang L, Zhang J, Chang G-l, Liu G, Yu D-d, Yu X-m, Zhao M-s, Ye B (2021) Evodiamine inhibits high-fat diet-induced colitis-associated cancer in mice through regulating the gut microbiota. J Integr Med 19(1):56\u201365","journal-title":"J Integr Med"},{"issue":"6","key":"1171_CR147","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.02612-22","volume":"10","author":"S-S Zhao","year":"2022","unstructured":"Zhao S-S, Chen L, Yang J, Wu Z-H, Wang X-Y, Zhang Q, Liu W-J, Liu H-X (2022) Altered gut microbial profile accompanied by abnormal fatty acid metabolism activity exacerbates endometrial cancer progression. Microbiol Spectr 10(6):e02612\u201322","journal-title":"Microbiol Spectr"},{"issue":"6","key":"1171_CR148","doi-asserted-by":"publisher","first-page":"3714","DOI":"10.3892\/or.2016.4734","volume":"35","author":"Y Lei","year":"2016","unstructured":"Lei Y, Zhen Y, Zhang W, Sun X, Lin X, Feng J, Luo H, Chen Z, Su C, Zeng B (2016) Exogenous hydrogen sulfide exerts proliferation, anti-apoptosis, angiopoiesis and migration effects via activating HSP90 pathway in EC109 cells. Oncol Rep 35(6):3714\u20133720","journal-title":"Oncol Rep"},{"key":"1171_CR149","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40168-017-0258-6","volume":"5","author":"L Xiao","year":"2017","unstructured":"Xiao L, Sonne SB, Feng Q, Chen N, Xia Z, Li X, Fang Z, Zhang D, Fj\u00e6re E, Midtb\u00f8 LK (2017) High-fat feeding rather than obesity drives taxonomical and functional changes in the gut microbiota in mice. Microbiome 5:1\u201312","journal-title":"Microbiome"},{"issue":"2","key":"1171_CR150","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.immuni.2015.01.010","volume":"42","author":"C Gur","year":"2015","unstructured":"Gur C, Ibrahim Y, Isaacson B, Yamin R, Abed J, Gamliel M, Enk J, Bar-On Y, Stanietsky-Kaynan N, Coppenhagen-Glazer S (2015) Binding of the Fap2 protein of Fusobacterium nucleatum to human inhibitory receptor TIGIT protects tumors from immune cell attack. Immunity 42(2):344\u2013355","journal-title":"Immunity"},{"issue":"5","key":"1171_CR151","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1001\/jamaoncol.2015.1377","volume":"1","author":"K Mima","year":"2015","unstructured":"Mima K, Sukawa Y, Nishihara R, Qian ZR, Yamauchi M, Inamura K, Kim SA, Masuda A, Nowak JA, Nosho K (2015) Fusobacterium nucleatum and T cells in colorectal carcinoma. JAMA Oncol 1(5):653\u2013661","journal-title":"JAMA Oncol"},{"key":"1171_CR152","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12934-020-01330-3","volume":"19","author":"K Kesh","year":"2020","unstructured":"Kesh K, Mendez R, Abdelrahman L, Banerjee S, Banerjee S (2020) Type 2 diabetes induced microbiome dysbiosis is associated with therapy resistance in pancreatic adenocarcinoma. Microb Cell Fact 19:1\u201314","journal-title":"Microb Cell Fact"},{"issue":"20","key":"1171_CR153","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2306776121","volume":"121","author":"J Chen","year":"2024","unstructured":"Chen J, Liu X, Zou Y, Gong J, Ge Z, Lin X, Zhang W, Huang H, Zhao J, Saw PE (2024) A high-fat diet promotes cancer progression by inducing gut microbiota\u2013mediated leucine production and PMN-MDSC differentiation. Proc Natl Acad Sci USA 121(20):e2306776121","journal-title":"Proc Natl Acad Sci USA"},{"issue":"25","key":"1171_CR154","doi-asserted-by":"publisher","first-page":"11537","DOI":"10.1073\/pnas.1001261107","volume":"107","author":"G Cuevas-Ramos","year":"2010","unstructured":"Cuevas-Ramos G, Petit CR, Marcq I, Boury M, Oswald E, Nougayr\u00e8de J-P (2010) Escherichia coli induces DNA damage in vivo and triggers genomic instability in mammalian cells. Proc Natl Acad Sci 107(25):11537\u201311542","journal-title":"Proc Natl Acad Sci"},{"issue":"12","key":"1171_CR155","doi-asserted-by":"publisher","first-page":"1932","DOI":"10.1136\/gutjnl-2013-305257","volume":"63","author":"A Cougnoux","year":"2014","unstructured":"Cougnoux A, Dalmasso G, Martinez R, Buc E, Delmas J, Gibold L, Sauvanet P, Darcha C, D\u00e9chelotte P, Bonnet M (2014) Bacterial genotoxin colibactin promotes colon tumour growth by inducing a senescence-associated secretory phenotype. Gut 63(12):1932\u20131942","journal-title":"Gut"},{"issue":"11","key":"1171_CR156","doi-asserted-by":"publisher","first-page":"4696","DOI":"10.1128\/IAI.00522-09","volume":"77","author":"J Putze","year":"2009","unstructured":"Putze J, Hennequin C, Nougayrede J-P, Zhang W, Homburg S, Karch H, Bringer M-A, Fayolle C, Carniel E, Rabsch W (2009) Genetic structure and distribution of the colibactin genomic island among members of the family Enterobacteriaceae. Infect Immun 77(11):4696\u20134703","journal-title":"Infect Immun"},{"issue":"7802","key":"1171_CR157","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1038\/s41586-020-2080-8","volume":"580","author":"C Pleguezuelos-Manzano","year":"2020","unstructured":"Pleguezuelos-Manzano C, Puschhof J, Rosendahl Huber A, van Hoeck A, Wood HM, Nomburg J, Gurjao C, Manders F, Dalmasso G, Stege PB (2020) Mutational signature in colorectal cancer caused by genotoxic pks\u2009+\u2009E. coli. Nature 580(7802):269\u2013273","journal-title":"Nature"},{"key":"1171_CR158","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1477-7819-12-164","volume":"12","author":"H Ajouz","year":"2014","unstructured":"Ajouz H, Mukherji D, Shamseddine A (2014) Secondary bile acids: an underrecognized cause of colon cancer. World J Surg Oncol 12:1\u20135","journal-title":"World J Surg Oncol"},{"issue":"11","key":"1171_CR159","doi-asserted-by":"publisher","first-page":"9925","DOI":"10.18632\/oncotarget.24066","volume":"9","author":"S Yamada","year":"2018","unstructured":"Yamada S, Takashina Y, Watanabe M, Nagamine R, Saito Y, Kamada N, Saito H (2018) Bile acid metabolism regulated by the gut microbiota promotes non-alcoholic steatohepatitis-associated hepatocellular carcinoma in mice. Oncotarget 9(11):9925","journal-title":"Oncotarget"},{"issue":"2","key":"1171_CR160","doi-asserted-by":"publisher","first-page":"G81","DOI":"10.1152\/ajpgi.00065.2015","volume":"310","author":"AY Dossa","year":"2016","unstructured":"Dossa AY, Escobar O, Golden J, Frey MR, Ford HR, Gayer CP (2016) Bile acids regulate intestinal cell proliferation by modulating EGFR and FXR signaling. Am J Physiol Gastrointest Liver Physiol 310(2):G81\u2013G92","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"4","key":"1171_CR161","first-page":"941","volume":"36","author":"HY Lee","year":"2010","unstructured":"Lee HY, Crawley S, Hokari R, Kwon S, Kim YS (2010) Bile acid regulates MUC2 transcription in colon cancer cells via positive EGFR\/PKC\/Ras\/ERK\/CREB, PI3K\/Akt\/I\u03baB\/NF-\u03baB and p38\/MSK1\/CREB pathways and negative JNK\/c-Jun\/AP-1 pathway. Int J Oncol 36(4):941\u2013953","journal-title":"Int J Oncol"},{"issue":"6","key":"1171_CR162","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1016\/j.ccell.2018.11.003","volume":"34","author":"M den Van Eynde","year":"2018","unstructured":"den Van Eynde M, Mlecnik B, Bindea G, Fredriksen T, Church SE, Lafontaine L, Haicheur N, Marliot F, Angelova M, Vasaturo A (2018) The link between the multiverse of immune microenvironments in metastases and the survival of colorectal cancer patients. Cancer Cell 34(6):1012-1026. e3","journal-title":"Cancer Cell"},{"issue":"7128","key":"1171_CR163","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1038\/nature05541","volume":"445","author":"A Ventura","year":"2007","unstructured":"Ventura A, Kirsch DG, McLaughlin ME, Tuveson DA, Grimm J, Lintault L, Newman J, Reczek EE, Weissleder R, Jacks T (2007) Restoration of p53 function leads to tumour regression in vivo. Nature 445(7128):661\u2013665","journal-title":"Nature"},{"issue":"225","key":"1171_CR164","doi-asserted-by":"publisher","first-page":"225ra28","DOI":"10.1126\/scitranslmed.3007607","volume":"6","author":"S Keerthivasan","year":"2014","unstructured":"Keerthivasan S, Aghajani K, Dose M, Molinero L, Khan MW, Venkateswaran V, Weber C, Emmanuel AO, Sun T, Bentrem DJ (2014) \u03b2-Catenin promotes colitis and colon cancer through imprinting of proinflammatory properties in T cells. Sci Transl Med 6(225):225ra28-225ra28","journal-title":"Sci Transl Med"},{"key":"1171_CR165","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00277","volume":"10","author":"D Parada Venegas","year":"2019","unstructured":"Parada Venegas D, la De Fuente MK, Landskron G, Gonz\u00e1lez MJ, Quera R, Dijkstra G, Harmsen HJ, Faber KN, Hermoso MA (2019) Short chain fatty acids (SCFAs)-mediated gut epithelial and immune regulation and its relevance for inflammatory bowel diseases. Front Immunol 10:277","journal-title":"Front Immunol"},{"issue":"4","key":"1171_CR166","doi-asserted-by":"publisher","first-page":"2648","DOI":"10.1111\/jcmm.14984","volume":"24","author":"T Liu","year":"2020","unstructured":"Liu T, Guo Z, Song X, Liu L, Dong W, Wang S, Xu M, Yang C, Wang B, Cao H (2020) High-fat diet\u2010induced dysbiosis mediates MCP\u20101\/CCR2 axis\u2010dependent M2 macrophage polarization and promotes intestinal adenoma\u2010adenocarcinoma sequence. J Cell Mol Med 24(4):2648\u20132662","journal-title":"J Cell Mol Med"},{"issue":"15","key":"1171_CR167","doi-asserted-by":"publisher","first-page":"5004","DOI":"10.7150\/ijbs.86717","volume":"19","author":"X Shao","year":"2023","unstructured":"Shao X, Liu L, Zhou Y, Zhong K, Gu J, Hu T, Yao Y, Zhou C, Chen W (2023) High-fat diet promotes colitis-associated tumorigenesis by altering gut microbial butyrate metabolism. Int J Biol Sci 19(15):5004","journal-title":"Int J Biol Sci"},{"key":"1171_CR168","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2024.217123","author":"L Xia","year":"2024","unstructured":"Xia L, Zhu X, Wang Y, Lu S (2024) The gut microbiota improves the efficacy of immune-checkpoint inhibitor immunotherapy against tumors: from association to cause and effect. Cancer Lett. https:\/\/doi.org\/10.1016\/j.canlet.2024.217123","journal-title":"Cancer Lett"},{"issue":"12","key":"1171_CR169","doi-asserted-by":"publisher","first-page":"9997","DOI":"10.1002\/jcb.27329","volume":"119","author":"H Li","year":"2018","unstructured":"Li H, Xia JQ, Zhu FS, Xi ZH, Pan CY, Gu LM, Tian YZ (2018) LPS promotes the expression of PD-L1 in gastric cancer cells through NF\u2010\u03baB activation. J Cell Biochem 119(12):9997\u201310004","journal-title":"J Cell Biochem"},{"issue":"6264","key":"1171_CR170","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1126\/science.aac4255","volume":"350","author":"A Sivan","year":"2015","unstructured":"Sivan A, Corrales L, Hubert N, Williams JB, Aquino-Michaels K, Earley ZM, Benyamin FW, Man Lei Y, Jabri B, Alegre M-L (2015) Commensal Bifidobacterium promotes antitumor immunity and facilitates anti\u2013PD-L1 efficacy. Science 350(6264):1084\u20131089","journal-title":"Science"},{"issue":"7960","key":"1171_CR171","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1038\/s41586-023-06026-3","volume":"617","author":"JS Park","year":"2023","unstructured":"Park JS, Gazzaniga FS, Wu M, Luthens AK, Gillis J, Zheng W, LaFleur MW, Johnson SB, Morad G, Park EM (2023) Targeting PD-L2\u2013RGMb overcomes microbiome-related immunotherapy resistance. Nature 617(7960):377\u2013385","journal-title":"Nature"},{"issue":"6371","key":"1171_CR172","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1126\/science.aao3290","volume":"359","author":"V Matson","year":"2018","unstructured":"Matson V, Fessler J, Bao R, Chongsuwat T, Zha Y, Alegre M-L, Luke JJ, Gajewski TF (2018) The commensal microbiome is associated with anti\u2013PD-1 efficacy in metastatic melanoma patients. Science 359(6371):104\u2013108","journal-title":"Science"},{"issue":"6575","key":"1171_CR173","doi-asserted-by":"publisher","first-page":"1632","DOI":"10.1126\/science.aaz7015","volume":"374","author":"CN Spencer","year":"2021","unstructured":"Spencer CN, McQuade JL, Gopalakrishnan V, McCulloch JA, Vetizou M, Cogdill AP, Khan MAW, Zhang X, White MG, Peterson CB (2021) Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response. Science 374(6575):1632\u20131640","journal-title":"Science"},{"issue":"7","key":"1171_CR174","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.1016\/j.cell.2024.02.022","volume":"187","author":"D Jia","year":"2024","unstructured":"Jia D, Wang Q, Qi Y, Jiang Y, He J, Lin Y, Sun Y, Xu J, Chen W, Fan L (2024) Microbial metabolite enhances immunotherapy efficacy by modulating T cell stemness in pan-cancer. Cell 187(7):1651-1665. e21","journal-title":"Cell"},{"issue":"5","key":"1171_CR175","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.1158\/2159-8290.CD-21-0929","volume":"12","author":"H Kawanabe-Matsuda","year":"2022","unstructured":"Kawanabe-Matsuda H, Takeda K, Nakamura M, Makino S, Karasaki T, Kakimi K, Nishimukai M, Ohno T, Omi J, Kano K (2022) Dietary lactobacillus-derived exopolysaccharide enhances immune-checkpoint blockade therapy. Cancer Discov 12(5):1336\u20131355","journal-title":"Cancer Discov"},{"issue":"6558","key":"1171_CR176","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1126\/science.abc9113","volume":"373","author":"ME Griffin","year":"2021","unstructured":"Griffin ME, Espinosa J, Becker JL, Luo J-D, Carroll TS, Jha JK, Fanger GR, Hang HC (2021) Enterococcus peptidoglycan remodeling promotes checkpoint inhibitor cancer immunotherapy. Science 373(6558):1040\u20131046","journal-title":"Science"},{"key":"1171_CR177","doi-asserted-by":"publisher","DOI":"10.1016\/j.micres.2025.128293","author":"L Zhong","year":"2025","unstructured":"Zhong L, Boopathi S, Purushothaman B, Tu Q, Zhang Y (2025) Gut microbiota\u2013indole-3-acetic acid axis in cancer: dual functions, mechanistic insights, and therapeutic potential. Microbiol Res. https:\/\/doi.org\/10.1016\/j.micres.2025.128293","journal-title":"Microbiol Res"},{"issue":"3","key":"1171_CR178","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1038\/s41591-022-01698-2","volume":"28","author":"JA McCulloch","year":"2022","unstructured":"McCulloch JA, Davar D, Rodrigues RR, Badger JH, Fang JR, Cole AM, Balaji AK, Vetizou M, Prescott SM, Fernandes MR (2022) Intestinal microbiota signatures of clinical response and immune-related adverse events in melanoma patients treated with anti-PD-1. Nat Med 28(3):545\u2013556","journal-title":"Nat Med"},{"issue":"8","key":"1171_CR179","doi-asserted-by":"publisher","first-page":"1432","DOI":"10.1038\/s41591-021-01406-6","volume":"27","author":"MC Andrews","year":"2021","unstructured":"Andrews MC, Duong CP, Gopalakrishnan V, Iebba V, Chen W-S, Derosa L, Khan MAW, Cogdill AP, White MG, Wong MC (2021) Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade. Nat Med 27(8):1432\u20131441","journal-title":"Nat Med"},{"issue":"1","key":"1171_CR180","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-024-01285-9","volume":"16","author":"M Hu","year":"2024","unstructured":"Hu M, Lin X, Sun T, Shao X, Huang X, Du W, Guo M, Zhu X, Zhou Y, Tong T (2024) Gut microbiome for predicting immune checkpoint blockade-associated adverse events. Genome Med 16(1):16","journal-title":"Genome Med"},{"issue":"5788","key":"1171_CR181","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1126\/science.1127059","volume":"313","author":"J-P Nougayr\u00e8de","year":"2006","unstructured":"Nougayr\u00e8de J-P, Homburg S, Taieb F, Boury M, Brzuszkiewicz E, Gottschalk G, Buchrieser C, Hacker J, Dobrindt U, Oswald E (2006) Escherichia coli induces DNA double-strand breaks in eukaryotic cells. Science 313(5788):848\u2013851","journal-title":"Science"},{"issue":"11","key":"1171_CR182","doi-asserted-by":"publisher","first-page":"3147","DOI":"10.1002\/ijc.32920","volume":"146","author":"A Lop\u00e8s","year":"2020","unstructured":"Lop\u00e8s A, Billard E, Casse AH, Vill\u00e9ger R, Veziant J, Roche G, Carrier G, Sauvanet P, Briat A, Pag\u00e8s F (2020) Colibactin-positive Escherichia coli induce a procarcinogenic immune environment leading to immunotherapy resistance in colorectal cancer. Int J Cancer 146(11):3147\u20133159","journal-title":"Int J Cancer"},{"key":"1171_CR183","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2023.108442","volume":"247","author":"M Delaye","year":"2023","unstructured":"Delaye M, Rousseau A, Mailly-Giacchetti L, Assoun S, Sokol H, Neuzillet C (2023) Obesity, cancer, and response to immune checkpoint inhibitors: could the gut microbiota be the mechanistic link? Pharmacol Ther 247:108442","journal-title":"Pharmacol Ther"},{"issue":"1","key":"1171_CR184","doi-asserted-by":"publisher","DOI":"10.1038\/s41522-024-00520-w","volume":"10","author":"M Luo","year":"2024","unstructured":"Luo M, Wang Q, Sun Y, Jiang Y, Wang Q, Gu Y, Hu Z, Chen Q, Xu J, Chen S (2024) Fasting-mimicking diet remodels gut microbiota and suppresses colorectal cancer progression. NPJ Biofilms Microbiomes 10(1):53","journal-title":"NPJ Biofilms Microbiomes"},{"issue":"1","key":"1171_CR185","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-56678-0","volume":"16","author":"M Tsenkova","year":"2025","unstructured":"Tsenkova M, Brauer M, Pozdeev VI, Kasakin M, Busi SB, Schmoetten M, Cheung D, Meyers M, Rodriguez F, Gaigneaux A (2025) Ketogenic diet suppresses colorectal cancer through the gut microbiome long chain fatty acid stearate. Nat Commun 16(1):1792","journal-title":"Nat Commun"},{"issue":"Supplement1","key":"1171_CR186","doi-asserted-by":"publisher","first-page":"S11","DOI":"10.1093\/oncolo\/oyae181.017","volume":"29","author":"S BAri","year":"2024","unstructured":"BAri S, Eysha M, Tannir N, George D, Conejo-Garcia J (2024) 73 fasting mediated gut microbiome modulation improves response to immune checkpoint therapy in Renal Cell Cancer. Oncologist 29(Supplement1):S11\u2013S12","journal-title":"Oncologist"},{"issue":"1","key":"1171_CR187","doi-asserted-by":"publisher","first-page":"13","DOI":"10.36401\/JIPO-21-10","volume":"5","author":"G Araji","year":"2022","unstructured":"Araji G, Maamari J, Ahmad FA, Zareef R, Chaftari P, Yeung S-CJ (2022) The emerging role of the gut microbiome in the cancer response to immune checkpoint inhibitors: a narrative review. J Immunotherapy Precision Oncol 5(1):13\u201325","journal-title":"J Immunotherapy Precision Oncol"},{"key":"1171_CR188","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2022.104163","author":"X Li","year":"2022","unstructured":"Li X, Zhang S, Guo G, Han J, Yu J (2022) Gut microbiome in modulating immune checkpoint inhibitors. EBioMedicine. https:\/\/doi.org\/10.1016\/j.ebiom.2022.104163","journal-title":"EBioMedicine"},{"issue":"10","key":"1171_CR189","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms10102048","volume":"10","author":"GH Al-Qadami","year":"2022","unstructured":"Al-Qadami GH, Secombe KR, Subramaniam CB, Wardill HR, Bowen JM (2022) Gut microbiota-derived short-chain fatty acids: impact on cancer treatment response and toxicities. Microorganisms 10(10):2048","journal-title":"Microorganisms"},{"key":"1171_CR190","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1200\/PO.20.00374","volume":"5","author":"M Jia","year":"2021","unstructured":"Jia M, Sangwan N, Tzeng A, Eng C (2021) Interplay between class II HLA genotypes and the microbiome and immune phenotypes in individuals with PTEN hamartoma tumor syndrome. JCO precision Oncol 5:357\u2013369","journal-title":"JCO precision Oncol"},{"issue":"3","key":"1171_CR191","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1530\/ERC-17-0442","volume":"25","author":"V Byrd","year":"2018","unstructured":"Byrd V, Getz T, Padmanabhan R, Arora H, Eng C (2018) The microbiome in PTEN hamartoma tumor syndrome. Endocr Relat Cancer 25(3):233\u2013243","journal-title":"Endocr Relat Cancer"},{"issue":"2","key":"1171_CR192","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/j.jaci.2016.03.059","volume":"139","author":"HH Chen","year":"2017","unstructured":"Chen HH, Haendel N, Ngeow J, Muller J, Huehn M, Yang H-T, Heindl M, Berbers R-M, Hegazy AN, Kionke J (2017) Immune dysregulation in patients with PTEN hamartoma tumor syndrome: analysis of FOXP3 regulatory T cells. J Allergy Clin Immunol 139(2):607-620. e15","journal-title":"J Allergy Clin Immunol"},{"issue":"6375","key":"1171_CR193","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1126\/science.aao4572","volume":"359","author":"D Chowell","year":"2018","unstructured":"Chowell D, Morris LG, Grigg CM, Weber JK, Samstein RM, Makarov V, Kuo F, Kendall SM, Requena D, Riaz N (2018) Patient HLA class I genotype influences cancer response to checkpoint blockade immunotherapy. Science 359(6375):582\u2013587","journal-title":"Science"},{"issue":"1","key":"1171_CR194","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-021-08114-x","volume":"21","author":"Z Lin","year":"2021","unstructured":"Lin Z, Huang L, Li SL, Gu J, Cui X, Zhou Y (2021) PTEN loss correlates with T cell exclusion across human cancers. BMC Cancer 21(1):429","journal-title":"BMC Cancer"},{"key":"1171_CR195","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2025.103025","author":"D Wekking","year":"2025","unstructured":"Wekking D, van den Ende T, Bijlsma MF, Vidal-Itriago A, Nieuwdorp M, van Laarhoven HW (2025) Fecal microbiota transplantation to enhance cancer treatment outcomes across different cancer types: a systematic literature review. Cancer Treat Rev. https:\/\/doi.org\/10.1016\/j.ctrv.2025.103025","journal-title":"Cancer Treat Rev"},{"issue":"15","key":"1171_CR196","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202411813","volume":"12","author":"J Wang","year":"2025","unstructured":"Wang J, Wang J, Yu Z, Wen H, Zhao C, Zhong J, Xiao C, Li Y, Xu J, Wang J (2025) Targeting the adenosine-mediated metabolic immune checkpoint with engineered probiotic for enhanced chemo\u2010immunotherapy. Adv Sci 12(15):2411813","journal-title":"Adv Sci"},{"issue":"8","key":"1171_CR197","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1016\/j.chom.2024.06.010","volume":"32","author":"Y Kim","year":"2024","unstructured":"Kim Y, Kim G, Kim S, Cho B, Kim S-Y, Do E-J, Bae D-J, Kim S, Kweon M-N, Song JS (2024) Fecal microbiota transplantation improves anti-PD-1 inhibitor efficacy in unresectable or metastatic solid cancers refractory to anti-PD-1 inhibitor. Cell Host Microbe 32(8):1380-1393. e9","journal-title":"Cell Host Microbe"},{"key":"1171_CR198","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1104224","volume":"14","author":"E Boucher","year":"2023","unstructured":"Boucher E, Plazy C, Richard ML, Suau A, Mangin I, Cornet M, Aldebert D, Toussaint B, Hannani D (2023) Inulin prebiotic reinforces host cancer immunosurveillance via \u0263\u03b4 T cell activation. Front Immunol 14:1104224","journal-title":"Front Immunol"},{"issue":"1","key":"1171_CR199","doi-asserted-by":"publisher","DOI":"10.1038\/s41522-025-00819-2","volume":"11","author":"L Huang","year":"2025","unstructured":"Huang L, Li Y, Zhang C, Jiang A, Zhu L, Mou W, Li K, Zhang J, Cui C, Cui X (2025) Microbiome meets immunotherapy: unlocking the hidden predictors of immune checkpoint inhibitors. NPJ Biofilms Microbiomes 11(1):180","journal-title":"NPJ Biofilms Microbiomes"},{"issue":"1","key":"1171_CR200","doi-asserted-by":"publisher","DOI":"10.1186\/s40164-023-00442-x","volume":"12","author":"M Zhang","year":"2023","unstructured":"Zhang M, Liu J, Xia Q (2023) Role of gut microbiome in cancer immunotherapy: from predictive biomarker to therapeutic target. Exp Hematol Oncol 12(1):84","journal-title":"Exp Hematol Oncol"},{"issue":"1","key":"1171_CR201","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-08915-1","volume":"15","author":"J Wang","year":"2025","unstructured":"Wang J, Cong Y, Tang B, Liu J, Pu K (2025) Integrative analysis of multi-omics data and gut microbiota composition reveals prognostic subtypes and predicts immunotherapy response in colorectal cancer using machine learning. Sci Rep 15(1):25268","journal-title":"Sci Rep"},{"issue":"3","key":"1171_CR202","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.ccell.2020.12.007","volume":"39","author":"C Huang","year":"2021","unstructured":"Huang C, Chen L, Savage SR, Eguez RV, Dou Y, Li Y, da Veiga Leprevost F, Jaehnig EJ, Lei JT, Wen B (2021) Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma. Cancer Cell 39(3):361-379. e16","journal-title":"Cancer Cell"},{"issue":"1","key":"1171_CR203","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-024-02017-8","volume":"23","author":"W Qin","year":"2024","unstructured":"Qin W, Li J, Gao N, Kong X, Guo L, Chen Y, Huang L, Chen X, Qi F (2024) Multiomics-based molecular subtyping based on the commensal microbiome predicts molecular characteristics and the therapeutic response in breast cancer. Mol Cancer 23(1):99","journal-title":"Mol Cancer"},{"issue":"1","key":"1171_CR204","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1007\/s10238-024-01324-0","volume":"24","author":"T Mei","year":"2024","unstructured":"Mei T, Wang T, Zhou Q (2024) Multi-omics and artificial intelligence predict clinical outcomes of immunotherapy in non-small cell lung cancer patients. Clin Exp Med 24(1):60","journal-title":"Clin Exp Med"},{"issue":"1","key":"1171_CR205","doi-asserted-by":"publisher","DOI":"10.1186\/s40364-024-00607-8","volume":"12","author":"C Zhu","year":"2024","unstructured":"Zhu C, Wang Y, Zhu R, Wang S, Xue J, Zhang D, Lan Z, Zhang C, Liang Y, Zhang N (2024) Gut microbiota and metabolites signatures of clinical response in anti-PD-1\/PD-L1 based immunotherapy of biliary tract cancer. Biomark Res 12(1):56","journal-title":"Biomark Res"},{"issue":"11","key":"1171_CR206","doi-asserted-by":"publisher","first-page":"2402","DOI":"10.2337\/dc12-0336","volume":"35","author":"K Esposito","year":"2012","unstructured":"Esposito K, Chiodini P, Colao A, Lenzi A, Giugliano D (2012) Metabolic syndrome and risk of cancer: a systematic review and meta-analysis. Diabetes Care 35(11):2402\u20132411","journal-title":"Diabetes Care"},{"issue":"12","key":"1171_CR207","doi-asserted-by":"publisher","first-page":"2150","DOI":"10.1002\/cncr.35235","volume":"130","author":"L Deng","year":"2024","unstructured":"Deng L, Liu T, Liu CA, Zhang Q, Song MM, Lin SQ, Wang YM, Zhang QS, Shi HP (2024) The association of metabolic syndrome score trajectory patterns with risk of all cancer types. Cancer 130(12):2150\u20132159","journal-title":"Cancer"},{"issue":"3","key":"1171_CR208","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0264634","volume":"17","author":"T L\u00f3pez-Jim\u00e9nez","year":"2022","unstructured":"L\u00f3pez-Jim\u00e9nez T, Duarte-Salles T, Plana-Ripoll O, Recalde M, Xavier-Cos F, Puente D (2022) Association between metabolic syndrome and 13 types of cancer in Catalonia: a matched case-control study. PLoS One 17(3):e0264634","journal-title":"PLoS One"},{"issue":"17","key":"1171_CR209","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21176073","volume":"21","author":"S Kyo","year":"2020","unstructured":"Kyo S, Nakayama K (2020) Endometrial cancer as a metabolic disease with dysregulated PI3K signaling: shedding light on novel therapeutic strategies. Int J Mol Sci 21(17):6073","journal-title":"Int J Mol Sci"},{"issue":"3","key":"1171_CR210","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24032652","volume":"24","author":"L-Y Tian","year":"2023","unstructured":"Tian L-Y, Smit DJ, J\u00fccker M (2023) The role of PI3K\/AKT\/mTOR signaling in hepatocellular carcinoma metabolism. Int J Mol Sci 24(3):2652","journal-title":"Int J Mol Sci"},{"key":"1171_CR211","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.819128","volume":"12","author":"Y Peng","year":"2022","unstructured":"Peng Y, Wang Y, Zhou C, Mei W, Zeng C (2022) PI3K\/Akt\/mTOR pathway and its role in cancer therapeutics: are we making headway? Front Oncol 12:819128","journal-title":"Front Oncol"},{"issue":"3","key":"1171_CR212","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15030703","volume":"15","author":"M Sirico","year":"2023","unstructured":"Sirico M, D\u2019Angelo A, Gianni C, Casadei C, Merloni F, De Giorgi U (2023) Current state and future challenges for PI3K inhibitors in cancer therapy. Cancers 15(3):703","journal-title":"Cancers"},{"issue":"8","key":"1171_CR213","doi-asserted-by":"publisher","first-page":"1796","DOI":"10.1002\/cam4.4579","volume":"11","author":"D Liu","year":"2022","unstructured":"Liu D, Weintraub MA, Garcia C, Goncalves MD, Sisk AE, Casas A, Harding JJ, Harnicar S, Drilon A, Jhaveri K (2022) Characterization, management, and risk factors of hyperglycemia during PI3K or AKT inhibitor treatment. Cancer Med 11(8):1796\u20131804","journal-title":"Cancer Med"},{"issue":"23","key":"1171_CR214","doi-asserted-by":"publisher","first-page":"2919","DOI":"10.1200\/JCO.2011.39.7356","volume":"30","author":"NL Busaidy","year":"2012","unstructured":"Busaidy NL, Farooki A, Dowlati A, Perentesis JP, Dancey JE, Doyle LA, Brell JM, Siu LL (2012) Management of metabolic effects associated with anticancer agents targeting the PI3K-Akt-mTOR pathway. J Clin Oncol 30(23):2919\u20132928","journal-title":"J Clin Oncol"},{"key":"1171_CR215","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2020-000725","author":"SK Boi","year":"2020","unstructured":"Boi SK, Orlandella RM, Gibson JT, Turbitt WJ, Wald G, Thomas L, Rosean CB, Norris KE, Bing M, Bertrand L (2020) Obesity diminishes response to PD-1-based immunotherapies in renal cancer. J Immunother Cancer. https:\/\/doi.org\/10.1136\/jitc-2020-000725","journal-title":"J Immunother Cancer"},{"issue":"9","key":"1171_CR216","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1097\/CJI.0000000000000389","volume":"44","author":"R-C Nie","year":"2021","unstructured":"Nie R-C, Chen G-M, Wang Y, Yuan S-Q, Zhou J, Duan J-L, Liu W-W, Chen S, Cai M-Y, Li Y-F (2021) Association between body mass index and survival outcomes in patients treated with immune checkpoint inhibitors: meta-analyses of individual patient data. J Immunother 44(9):371\u2013375","journal-title":"J Immunother"},{"key":"1171_CR217","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S289446","author":"K Hisanaga","year":"2021","unstructured":"Hisanaga K, Uchino H, Kakisu N, Miyagi M, Yoshikawa F, Sato G, Isobe K, Kishi K, Homma S, Hirose T (2021) Pre-existing diabetes limits survival rate after immune checkpoint inhibitor treatment for advanced lung cancer: a retrospective study in Japan. Diabetes Metab Syndr Obes. https:\/\/doi.org\/10.2147\/DMSO.S289446","journal-title":"Diabetes Metab Syndr Obes"},{"key":"1171_CR218","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40425-019-0527-y","volume":"7","author":"A Cortellini","year":"2019","unstructured":"Cortellini A, Bersanelli M, Buti S, Cannita K, Santini D, Perrone F, Giusti R, Tiseo M, Michiara M, Di Marino P (2019) A multicenter study of body mass index in cancer patients treated with anti-PD-1\/PD-L1 immune checkpoint inhibitors: when overweight becomes favorable. J Immunother Cancer 7:1\u201311","journal-title":"J Immunother Cancer"},{"issue":"8","key":"1171_CR219","doi-asserted-by":"publisher","first-page":"e2425363","DOI":"10.1001\/jamanetworkopen.2024.25363","volume":"7","author":"Y Ihara","year":"2024","unstructured":"Ihara Y, Sawa K, Imai T, Bito T, Shimomura Y, Kawai R, Shintani A (2024) Immunotherapy and overall survival among patients with advanced non\u2013small cell lung cancer and obesity. JAMA Netw Open 7(8):e2425363\u2013e2425363","journal-title":"JAMA Netw Open"},{"issue":"6","key":"1171_CR220","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1038\/oby.2008.55","volume":"16","author":"C Kim","year":"2008","unstructured":"Kim C, Lee S, Kim Y, Kim B, Choi H, Kawada T, Kwon B, Yu R (2008) Visceral fat accumulation induced by a high-fat diet causes the atrophy of mesenteric lymph nodes in obese mice. Obesity 16(6):1261\u20131269","journal-title":"Obesity"},{"issue":"18","key":"1171_CR221","doi-asserted-by":"publisher","first-page":"3803","DOI":"10.1182\/blood-2009-03-213595","volume":"114","author":"H Yang","year":"2009","unstructured":"Yang H, Youm Y-H, Vandanmagsar B, Rood J, Kumar KG, Butler AA, Dixit VD (2009) Obesity accelerates thymic aging. Blood 114(18):3803\u20133812","journal-title":"Blood"},{"issue":"10","key":"1171_CR222","doi-asserted-by":"publisher","first-page":"2140","DOI":"10.1002\/oby.21620","volume":"24","author":"SK Boi","year":"2016","unstructured":"Boi SK, Buchta CM, Pearson NA, Francis MB, Meyerholz DK, Grobe JL, Norian LA (2016) Obesity alters immune and metabolic profiles: new insight from obese-resistant mice on high\u2010fat diet. Obesity 24(10):2140\u20132149","journal-title":"Obesity"},{"issue":"1","key":"1171_CR223","doi-asserted-by":"publisher","DOI":"10.3892\/mco.2023.2703","volume":"20","author":"H Guo","year":"2023","unstructured":"Guo H, Lin X-Y, Feng S, Wang C, Yuan L-Q, Sheng X-G, Li D-P (2023) Prognostic value of obesity in patients with cancer treated with immune checkpoint inhibitors: an updated meta\u2011analysis and systematic review. Mol Clin Oncol 20(1):5","journal-title":"Mol Clin Oncol"},{"issue":"1","key":"1171_CR224","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2024-009734","volume":"13","author":"SL Alden","year":"2025","unstructured":"Alden SL, Charmsaz S, Li HL, Tsai H-L, Danilova L, Munjal K, Brancati M, Warner A, Howe K, Griffin E (2025) Pan-tumor analysis to investigate the obesity paradox in immune checkpoint blockade. J Immunother Cancer 13(1):e009734","journal-title":"J Immunother Cancer"},{"issue":"17","key":"1171_CR225","doi-asserted-by":"publisher","DOI":"10.3390\/cancers17172765","volume":"17","author":"C Golban","year":"2025","unstructured":"Golban C, Susa S-R, Varga N-I, Ivan C-S, Schirta PO, Schirta NC, Negru AG, Saftescu S, Negru SM (2025) The impact of body composition on outcomes in NSCLC patients treated with immune checkpoint inhibitors: a systematic review. Cancers 17(17):2765","journal-title":"Cancers"},{"issue":"2","key":"1171_CR226","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.13758","volume":"16","author":"J Yu","year":"2025","unstructured":"Yu J, Ahn H, Han KY, Song W, Sung HH, Jeon HG, Jeong BC, Seo SI, Jeon SS, Park SH (2025) Paradoxical effect of myosteatosis on the immune checkpoint inhibitor response in metastatic renal cell carcinoma. J Cachexia Sarcopenia Muscle 16(2):e13758","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"6","key":"1171_CR227","doi-asserted-by":"publisher","first-page":"e2417115","DOI":"10.1001\/jamanetworkopen.2024.17115","volume":"7","author":"C Liu","year":"2024","unstructured":"Liu C, Liu T, Deng L, Zhang Q, Song M, Shi J, Liu C, Xie H, Chen Y, Lin S (2024) Sarcopenic obesity and outcomes for patients with cancer. JAMA Netw Open 7(6):e2417115\u2013e2417115","journal-title":"JAMA Netw Open"},{"key":"1171_CR228","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2025.07.002","author":"B K\u00f6yl\u00fc","year":"2025","unstructured":"K\u00f6yl\u00fc B, Sulu C, Yumuk VD, Yumuk PF, Elsevier (2025) The impact of sarcopenic obesity on cancer clinical outcomes. Semin Cancer Biol. https:\/\/doi.org\/10.1016\/j.semcancer.2025.07.002","journal-title":"Semin Cancer Biol"},{"issue":"1","key":"1171_CR229","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2024.2442116","volume":"14","author":"H Kawachi","year":"2025","unstructured":"Kawachi H, Yamada T, Tamiya M, Negi Y, Kijima T, Goto Y, Nakao A, Shiotsu S, Tanimura K, Takeda T (2025) Clinical impact of cancer cachexia on the outcome of patients with non-small cell lung cancer with PD-L1 tumor proportion scores of \u2265 50% receiving pembrolizumab monotherapy versus immune checkpoint inhibitor with chemotherapy. Oncoimmunology 14(1):2442116","journal-title":"Oncoimmunology"},{"issue":"3","key":"1171_CR230","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1097\/CMR.0000000000000656","volume":"30","author":"TT Wind","year":"2020","unstructured":"Wind TT, Gacesa R, Vila AV, de Haan JJ, Jalving M, Weersma RK, Hospers GA (2020) Gut microbial species and metabolic pathways associated with response to treatment with immune checkpoint inhibitors in metastatic melanoma. Melanoma Res 30(3):235\u2013246","journal-title":"Melanoma Res"},{"issue":"1","key":"1171_CR231","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1186\/s12885-021-09156-x","volume":"22","author":"NA Thompson","year":"2022","unstructured":"Thompson NA, Stewart GD, Welsh SJ, Doherty GJ, Robinson MJ, Neville BA, Vervier K, Harris SR, Adams DJ, Dalchau K (2022) The MITRE trial protocol: a study to evaluate the microbiome as a biomarker of efficacy and toxicity in cancer patients receiving immune checkpoint inhibitor therapy. BMC Cancer 22(1):99","journal-title":"BMC Cancer"},{"issue":"3","key":"1171_CR232","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1038\/s41591-024-02803-3","volume":"30","author":"JR Bj\u00f6rk","year":"2024","unstructured":"Bj\u00f6rk JR, Bolte LA, Thomas AM, Lee KA, Rossi N, Wind TT, Smit LM, Armanini F, Asnicar F, Blanco-Miguez A (2024) Longitudinal gut microbiome changes in immune checkpoint blockade-treated advanced melanoma. Nat Med 30(3):785\u2013796","journal-title":"Nat Med"},{"issue":"3","key":"1171_CR233","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1038\/s41591-022-01695-5","volume":"28","author":"KA Lee","year":"2022","unstructured":"Lee KA, Thomas AM, Bolte LA, Bj\u00f6rk JR, de Ruijter LK, Armanini F, Asnicar F, Blanco-Miguez A, Board R, Calbet-Llopart N (2022) Cross-cohort gut microbiome associations with immune checkpoint inhibitor response in advanced melanoma. Nat Med 28(3):535\u2013544","journal-title":"Nat Med"}],"container-title":["Journal of Physiology and Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13105-026-01171-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13105-026-01171-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13105-026-01171-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T06:02:30Z","timestamp":1773986550000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13105-026-01171-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,20]]},"references-count":233,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["1171"],"URL":"https:\/\/doi.org\/10.1007\/s13105-026-01171-5","relation":{},"ISSN":["1138-7548","1877-8755"],"issn-type":[{"value":"1138-7548","type":"print"},{"value":"1877-8755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,20]]},"assertion":[{"value":"4 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"30"}}