{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T05:09:51Z","timestamp":1780463391214,"version":"3.54.1"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"the Youth Cultivation Program Project of the Fifth Affiliated Hospital of Zhengzhou University","award":["YQ2024038"],"award-info":[{"award-number":["YQ2024038"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Physiol Biochem"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s13105-026-01195-x","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T04:42:02Z","timestamp":1780461722000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["TRIM38 alleviates the pathogenesis of diabetic nephropathy by suppressing NF-\u03baB activation via inducing RIPK1 degradation"],"prefix":"10.1007","volume":"82","author":[{"given":"Yifan","family":"Fang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojuan","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianlin","family":"Dou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengyuan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,3]]},"reference":[{"key":"1195_CR1","doi-asserted-by":"crossref","unstructured":"Luo Y, Zhang W, Qin G (2024) Metabolomics in diabetic nephropathy: Unveiling novel biomarkers for diagnosis (Review). Mol Med Rep 30","DOI":"10.3892\/mmr.2024.13280"},{"key":"1195_CR2","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1146\/annurev.pathol.4.110807.092150","volume":"6","author":"YS Kanwar","year":"2011","unstructured":"Kanwar YS, Sun L, Xie P, Liu FY, Chen S (2011) A glimpse of various pathogenetic mechanisms of diabetic nephropathy. Annu Rev Pathol 6:395\u2013423","journal-title":"Annu Rev Pathol"},{"key":"1195_CR3","doi-asserted-by":"publisher","first-page":"2560","DOI":"10.1056\/NEJMoa0802987","volume":"358","author":"AC Group","year":"2008","unstructured":"Group AC, Patel A, MacMahon S, Chalmers J, Neal B, Billot L et al (2008) Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med 358:2560\u20132572","journal-title":"N Engl J Med"},{"key":"1195_CR4","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1056\/NEJMoa1407963","volume":"371","author":"S Zoungas","year":"2014","unstructured":"Zoungas S, Chalmers J, Neal B, Billot L, Li Q, Hirakawa Y et al (2014) Follow-up of blood-pressure lowering and glucose control in type 2 diabetes. N Engl J Med 371:1392\u20131406","journal-title":"N Engl J Med"},{"key":"1195_CR5","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1038\/s41419-025-07396-4","volume":"16","author":"S Sunilkumar","year":"2025","unstructured":"Sunilkumar S, Subrahmanian SM, Yerlikaya EI, Toro AL, Harhaj EW, Kimball SR et al (2025) REDD1 expression in podocytes facilitates renal inflammation and pyroptosis in streptozotocin-induced diabetic nephropathy. Cell Death Dis 16:79","journal-title":"Cell Death Dis"},{"key":"1195_CR6","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/s00018-024-05567-8","volume":"82","author":"L Chen","year":"2025","unstructured":"Chen L, Li D, Zhan Z, Quan J, Peng J, Huang Z et al (2025) Sirtuin 2 exacerbates renal tubule injury and inflammation in diabetic mice via deacetylation of c-Jun\/c-Fos. Cell Mol Life Sci 82:45","journal-title":"Cell Mol Life Sci"},{"key":"1195_CR7","doi-asserted-by":"publisher","first-page":"1690","DOI":"10.1080\/13880209.2022.2112239","volume":"60","author":"J Li","year":"2022","unstructured":"Li J, Zhang J, Yang M, Huang X, Zhang M, Fang X et al (2022) Kirenol alleviates diabetic nephropathy via regulating TGF-beta\/Smads and the NF-kappaB signal pathway. Pharm Biol 60:1690\u20131700","journal-title":"Pharm Biol"},{"key":"1195_CR8","doi-asserted-by":"publisher","first-page":"154251","DOI":"10.1016\/j.phymed.2022.154251","volume":"104","author":"M Wang","year":"2022","unstructured":"Wang M, Liu X, Wang Z, Xu Q (2022) The extract of Polygala fallax Hemsl. slows the progression of diabetic nephropathy by targeting TLR4 anti-inflammation and MMP-2\/9-mediated anti-fibrosis in vitro. Phytomedicine 104:154251","journal-title":"Phytomedicine"},{"key":"1195_CR9","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1039\/D0FO02335C","volume":"12","author":"MY Qi","year":"2021","unstructured":"Qi MY, He YH, Cheng Y, Fang Q, Ma RY, Zhou SJ et al (2021) Icariin ameliorates streptozocin-induced diabetic nephropathy through suppressing the TLR4\/NF-kappaB signal pathway. Food Funct 12:1241\u20131251","journal-title":"Food Funct"},{"key":"1195_CR10","doi-asserted-by":"publisher","first-page":"156314","DOI":"10.1016\/j.phymed.2024.156314","volume":"136","author":"Q Feng","year":"2025","unstructured":"Feng Q, Yu X, Xie J, Liu F, Zhang X, Li S et al (2025) Phillygenin improves diabetic nephropathy by inhibiting inflammation and apoptosis via regulating TLR4\/MyD88\/NF-kappaB and PI3K\/AKT\/GSK3beta signaling pathways. Phytomedicine 136:156314","journal-title":"Phytomedicine"},{"key":"1195_CR11","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1186\/s12964-024-01565-2","volume":"22","author":"S Cui","year":"2024","unstructured":"Cui S, Chen X, Li J, Wang W, Meng D, Zhu S et al (2024) Endothelial CXCR2 deficiency attenuates renal inflammation and glycocalyx shedding through NF-kappaB signaling in diabetic kidney disease. Cell Commun Signal 22:191","journal-title":"Cell Commun Signal"},{"key":"1195_CR12","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.coi.2010.10.021","volume":"23","author":"FW McNab","year":"2011","unstructured":"McNab FW, Rajsbaum R, Stoye JP, O\u2019Garra A (2011) Tripartite-motif proteins and innate immune regulation. Curr Opin Immunol 23:46\u201356","journal-title":"Curr Opin Immunol"},{"key":"1195_CR13","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1038\/nri2413","volume":"8","author":"K Ozato","year":"2008","unstructured":"Ozato K, Shin DM, Chang TH, Morse HC 3rd (2008) TRIM family proteins and their emerging roles in innate immunity. Nat Rev Immunol 8:849\u2013860","journal-title":"Nat Rev Immunol"},{"key":"1195_CR14","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1038\/cmi.2016.66","volume":"14","author":"MM Hu","year":"2017","unstructured":"Hu MM, Shu HB (2017) Multifaceted roles of TRIM38 in innate immune and inflammatory responses. Cell Mol Immunol 14:331\u2013338","journal-title":"Cell Mol Immunol"},{"key":"1195_CR15","doi-asserted-by":"publisher","first-page":"2069","DOI":"10.1007\/s11010-023-04823-y","volume":"479","author":"K Zhang","year":"2024","unstructured":"Zhang K, Lin G, Nie Z, Jin S, Bing X, Li Z et al (2024) TRIM38 suppresses migration, invasion, metastasis, and proliferation in non-small cell lung cancer (NSCLC) via regulating the AMPK\/NF-kappaB\/NLRP3 pathway. Mol Cell Biochem 479:2069\u20132079","journal-title":"Mol Cell Biochem"},{"key":"1195_CR16","doi-asserted-by":"publisher","first-page":"108048","DOI":"10.1016\/j.intimp.2021.108048","volume":"99","author":"S Hu","year":"2021","unstructured":"Hu S, Li Y, Wang B, Peng K (2021) TRIM38 protects chondrocytes from IL-1beta-induced apoptosis and degeneration via negatively modulating nuclear factor (NF)-kappaB signaling. Int Immunopharmacol 99:108048","journal-title":"Int Immunopharmacol"},{"key":"1195_CR17","doi-asserted-by":"publisher","first-page":"e13815","DOI":"10.7717\/peerj.13815","volume":"10","author":"Z Lu","year":"2022","unstructured":"Lu Z, Deng M, Ma G, Chen L (2022) TRIM38 protects H9c2 cells from hypoxia\/reoxygenation injury via the TRAF6\/TAK1\/NF-kappaB signalling pathway. PeerJ 10:e13815","journal-title":"PeerJ"},{"key":"1195_CR18","doi-asserted-by":"crossref","unstructured":"Shao N, Wang J, Liu J, Zhang J, Zhang B, Sun X et al (2026) Mitochondrial Dynamics in Diabetic Kidney Disease: Underlying Mechanisms and Novel Therapeutics. Int J Mol Sci 27","DOI":"10.3390\/ijms27052429"},{"key":"1195_CR19","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1038\/nrm3683","volume":"14","author":"D Ofengeim","year":"2013","unstructured":"Ofengeim D, Yuan J (2013) Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death. Nat Rev Mol Cell Biol 14:727\u2013736","journal-title":"Nat Rev Mol Cell Biol"},{"key":"1195_CR20","doi-asserted-by":"publisher","first-page":"116642","DOI":"10.1016\/j.bcp.2024.116642","volume":"231","author":"A Ambujakshan","year":"2025","unstructured":"Ambujakshan A, Sahu BD (2025) Unraveling the role of RIPKs in diabetic kidney disease and its therapeutic perspectives. Biochem Pharmacol 231:116642","journal-title":"Biochem Pharmacol"},{"key":"1195_CR21","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1159\/000529995","volume":"9","author":"Q Yu","year":"2023","unstructured":"Yu Q, Chen Y, Zhao Y, Huang S, Xin X, Jiang L et al (2023) Nephropathy Is Aggravated by Fatty Acids in Diabetic Kidney Disease through Tubular Epithelial Cell Necroptosis and Is Alleviated by an RIPK-1 Inhibitor. Kidney Dis (Basel) 9:408\u2013423","journal-title":"Kidney Dis (Basel)"},{"key":"1195_CR22","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s11658-022-00350-8","volume":"27","author":"J Lan","year":"2022","unstructured":"Lan J, Xu B, Shi X, Pan Q, Tao Q (2022) WTAP-mediated N(6)-methyladenosine modification of NLRP3 mRNA in kidney injury of diabetic nephropathy. Cell Mol Biol Lett 27:51","journal-title":"Cell Mol Biol Lett"},{"key":"1195_CR23","doi-asserted-by":"publisher","first-page":"104975","DOI":"10.1016\/j.jbc.2023.104975","volume":"299","author":"K Myakala","year":"2023","unstructured":"Myakala K, Wang XX, Shults NV, Krawczyk E, Jones BA, Yang X et al (2023) NAD metabolism modulates inflammation and mitochondria function in diabetic kidney disease. J Biol Chem 299:104975","journal-title":"J Biol Chem"},{"key":"1195_CR24","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/s12967-021-03197-3","volume":"20","author":"D Qiu","year":"2022","unstructured":"Qiu D, Song S, Wang Y, Bian Y, Wu M, Wu H et al (2022) NAD(P)H: quinone oxidoreductase 1 attenuates oxidative stress and apoptosis by regulating Sirt1 in diabetic nephropathy. J Transl Med 20:44","journal-title":"J Transl Med"},{"key":"1195_CR25","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1080\/13510002.2018.1487174","volume":"23","author":"Y Ogura","year":"2018","unstructured":"Ogura Y, Kitada M, Monno I, Kanasaki K, Watanabe A, Koya D (2018) Renal mitochondrial oxidative stress is enhanced by the reduction of Sirt3 activity, in Zucker diabetic fatty rats. Redox Rep 23:153\u2013159","journal-title":"Redox Rep"},{"key":"1195_CR26","doi-asserted-by":"crossref","unstructured":"Vaisar T, Durbin-Johnson B, Whitlock K, Babenko I, Mehrotra R, Rocke DM et al (2019) Erratum. Urine Complement Proteins and the Risk of Kidney Disease Progression and Mortality in Type 2 Diabetes. Diabetes Care 2018;41:2361\u20132369. Diabetes Care 42:1155","DOI":"10.2337\/dc19-er06a"},{"key":"1195_CR27","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.2337\/dc17-0110","volume":"40","author":"CM Rhee","year":"2017","unstructured":"Rhee CM, Kovesdy CP, Ravel VA, Streja E, Brunelli SM, Soohoo M et al (2017) Association of Glycemic Status During Progression of Chronic Kidney Disease With Early Dialysis Mortality in Patients With Diabetes. Diabetes Care 40:1050\u20131057","journal-title":"Diabetes Care"},{"key":"1195_CR28","doi-asserted-by":"publisher","first-page":"100382","DOI":"10.1016\/j.jlr.2023.100382","volume":"64","author":"X Yao","year":"2023","unstructured":"Yao X, Dong R, Hu S, Liu Z, Cui J, Hu F et al (2023) Tripartite motif 38 alleviates the pathological process of NAFLD-NASH by promoting Table 2 degradation. J Lipid Res 64:100382","journal-title":"J Lipid Res"},{"key":"1195_CR29","doi-asserted-by":"publisher","first-page":"104780","DOI":"10.1016\/j.isci.2022.104780","volume":"25","author":"Z Lu","year":"2022","unstructured":"Lu Z, Hao C, Qian H, Zhao Y, Bo X, Yao Y et al (2022) Tripartite motif 38 attenuates cardiac fibrosis after myocardial infarction by suppressing TAK1 activation via Table 2\/3 degradation. iScience 25:104780","journal-title":"iScience"},{"key":"1195_CR30","doi-asserted-by":"publisher","first-page":"2567","DOI":"10.4049\/jimmunol.1103255","volume":"188","author":"W Zhao","year":"2012","unstructured":"Zhao W, Wang L, Zhang M, Yuan C, Gao C (2012) E3 ubiquitin ligase tripartite motif 38 negatively regulates TLR-mediated immune responses by proteasomal degradation of TNF receptor-associated factor 6 in macrophages. J Immunol 188:2567\u20132574","journal-title":"J Immunol"},{"key":"1195_CR31","first-page":"145","volume":"9","author":"J Wu","year":"2016","unstructured":"Wu J, Jin Z, Zheng H, Yan LJ (2016) Sources and implications of NADH\/NAD(+) redox imbalance in diabetes and its complications. Diabetes Metab Syndr Obes 9:145\u2013153","journal-title":"Diabetes Metab Syndr Obes"},{"key":"1195_CR32","doi-asserted-by":"publisher","first-page":"1384953","DOI":"10.3389\/fendo.2024.1384953","volume":"15","author":"S Yang","year":"2024","unstructured":"Yang S, Gong W, Wang Y, Hao C, Guan Y (2024) Unraveling the nexus of NAD+ metabolism and diabetic kidney disease: insights from murine models and human data. Front Endocrinol (Lausanne) 15:1384953","journal-title":"Front Endocrinol (Lausanne)"},{"key":"1195_CR33","doi-asserted-by":"crossref","unstructured":"Li X, Li Y, Li F, Chen Q, Zhao Z, Liu X et al (2022) NAD(+) Anabolism Disturbance Causes Glomerular Mesangial Cell Injury in Diabetic Nephropathy. Int J Mol Sci 23","DOI":"10.3390\/ijms23073458"},{"key":"1195_CR34","doi-asserted-by":"publisher","first-page":"102033","DOI":"10.1016\/j.redox.2021.102033","volume":"45","author":"X Dai","year":"2021","unstructured":"Dai X, Liao R, Liu C, Liu S, Huang H, Liu J et al (2021) Epigenetic regulation of TXNIP-mediated oxidative stress and NLRP3 inflammasome activation contributes to SAHH inhibition-aggravated diabetic nephropathy. Redox Biol 45:102033","journal-title":"Redox Biol"},{"key":"1195_CR35","doi-asserted-by":"publisher","first-page":"123307","DOI":"10.1016\/j.lfs.2024.123307","volume":"361","author":"SM Selim","year":"2025","unstructured":"Selim SM, El Fayoumi HM, El-Sayed NM, Mehanna ET, Hazem RM (2025) Alogliptin attenuates STZ-induced diabetic nephropathy in rats through the modulation of autophagy, apoptosis, and inflammation pathways: Targeting NF-kappaB and AMPK\/mTOR pathway. Life Sci 361:123307","journal-title":"Life Sci"},{"key":"1195_CR36","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/s41065-024-00345-9","volume":"161","author":"Y Feng","year":"2024","unstructured":"Feng Y, Zhang Y, Gao F, Liu M, Luo Y (2024) HOXD9\/APOC1 axis promotes macrophage M1 polarization to exacerbate diabetic kidney disease progression through activating NF-kappaB signaling pathway. Hereditas 161:40","journal-title":"Hereditas"},{"key":"1195_CR37","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1073\/pnas.1318227111","volume":"111","author":"MM Hu","year":"2014","unstructured":"Hu MM, Yang Q, Zhang J, Liu SM, Zhang Y, Lin H et al (2014) TRIM38 inhibits TNFalpha- and IL-1beta-triggered NF-kappaB activation by mediating lysosome-dependent degradation of Table 2\/3. Proc Natl Acad Sci U S A 111:1509\u20131514","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1195_CR38","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1186\/s12967-021-03173-x","volume":"19","author":"X Wang","year":"2021","unstructured":"Wang X, He H, Rui W, Zhang N, Zhu Y, Xie X (2021) TRIM38 triggers the uniquitination and degradation of glucose transporter type 1 (GLUT1) to restrict tumor progression in bladder cancer. J Transl Med 19:508","journal-title":"J Transl Med"},{"key":"1195_CR39","doi-asserted-by":"publisher","first-page":"13636","DOI":"10.1074\/jbc.M600620200","volume":"281","author":"H Li","year":"2006","unstructured":"Li H, Kobayashi M, Blonska M, You Y, Lin X (2006) Ubiquitination of RIP is required for tumor necrosis factor alpha-induced NF-kappaB activation. J Biol Chem 281:13636\u201313643","journal-title":"J Biol Chem"},{"key":"1195_CR40","doi-asserted-by":"publisher","first-page":"850","DOI":"10.2337\/db09-1342","volume":"59","author":"T Jiang","year":"2010","unstructured":"Jiang T, Huang Z, Lin Y, Zhang Z, Fang D, Zhang DD (2010) The protective role of Nrf2 in streptozotocin-induced diabetic nephropathy. Diabetes 59:850\u2013860","journal-title":"Diabetes"}],"container-title":["Journal of Physiology and Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13105-026-01195-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13105-026-01195-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13105-026-01195-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T04:42:09Z","timestamp":1780461729000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13105-026-01195-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,3]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["1195"],"URL":"https:\/\/doi.org\/10.1007\/s13105-026-01195-x","relation":{},"ISSN":["1138-7548","1877-8755"],"issn-type":[{"value":"1138-7548","type":"print"},{"value":"1877-8755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,3]]},"assertion":[{"value":"22 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The clinical study was approved by the Medical Ethics Committee of the Fifth Affiliated Hospital of Zhengzhou University and rigorously executed based on the ethical guidance of the Declaration of Helsinki. All animal care and experimental procedures complied with the Guide for the Care and Use of Laboratory Animals and were approved by the Ethics Committee of the Fifth Affiliated Hospital of Zhengzhou University.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"57"}}