{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:24:41Z","timestamp":1792783481881,"version":"4.5.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universidad de Extremadura","id":[{"id":"https:\/\/ror.org\/0174shg90","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Physiol Biochem"],"published-print":{"date-parts":[[2026,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Lipoxygenases exhibit a leading role in cancer development and growth. Additionally, pancreatic stellate cells (PSCs) are pivotal in the formation of fibrotic tissue in pancreatic tumors. In this work, we have studied the effects of the 5-lipoxygenase (5-LOX) inhibitor, zileuton, on rat PSCs. Cell viability was analyzed by employing crystal violet. Reactive oxygen species (ROS) generation, reduced (GSH) and oxidized (GSSG) levels of glutathione and protein and lipid oxidation were analyzed by fluorescence and colorimetric methods respectively. The phosphorylation of nuclear factor erythroid 2-related factor (Nrf2) and the expression of superoxide dismutase (SOD) was studied by western blotting. The effect of zileuton on erastin-induced ferroptosis was assessed by colorimetric methods. Mitochondrial metabolic activity was studied employing Alamar Blue\n                    <jats:sup>\u00ae<\/jats:sup>\n                    . Mitochondrial membrane potential was monitored by fluorescence techniques. The results show that the 5-LOX inhibitor protected PSCs against oxidation evoked by hydrogen peroxide, which induced an increase in CM-H\n                    <jats:sub>2<\/jats:sub>\n                    DCFDA-derived fluorescence, a decrease in the reduced\/oxidized glutathione ratio and increases in the detection of lipid and protein oxidation. In the presence of zileuton, increases in the phosphorylation of nuclear factor erythroid 2-related factor and in the expression of the antioxidant enzymes catalase, glutamate-cysteine ligase,,heme oxygenase-1, NAD(P)H quinone oxidoreductase 1, and superoxide dismutases 1 and 2 were observed. Additionally, zileuton diminished erastin-evoked ferroptosis. Finally, a drop in the reduction of resazurin by mitochondria and a slowing of the Krebs cycle flow rate were observed, whereas no detectable changes in mitochondrial membrane potential were noted in the presence of zileuton. We conclude that the inhibition of 5-LOX by zileuton places cells in a state of antioxidant readiness coupled with a protected metabolic deceleration.\n                  <\/jats:p>","DOI":"10.1007\/s13105-026-01224-9","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T05:01:06Z","timestamp":1789534866000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Zileuton protects pancreatic stellate cells from oxidative stress and ferroptosis by modulating the Nrf2 pathway and mitochondrial activity"],"prefix":"10.1007","volume":"82","author":[{"given":"Mat\u00edas","family":"Estar\u00e1s","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e1ndido","family":"Ortiz-Plac\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salom\u00e9","family":"Mart\u00ednez-Morcillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remigio","family":"Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Fern\u00e1ndez-Bermejo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Sol\u00eds-Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Mar\u00eda","family":"Mateos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Iovanna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Santofimia-Casta\u00f1o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Gonzalez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"1224_CR1","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1002\/path.6211","volume":"262","author":"R Ando","year":"2024","unstructured":"Ando R, Shiraki Y, Miyai Y et al (2024) Meflin is a marker of pancreatic stellate cells involved in fibrosis and epithelial regeneration in the pancreas. J Pathol 262:61\u201375. https:\/\/doi.org\/10.1002\/path.6211","journal-title":"J Pathol"},{"key":"1224_CR2","doi-asserted-by":"publisher","unstructured":"Li H, Liu D, Li K et al (2024) Pancreatic stellate cells and the interleukin family: Linking fibrosis and immunity to pancreatic ductal adenocarcinoma (Review). Mol Med Rep 30. https:\/\/doi.org\/10.3892\/mmr.2024.13283","DOI":"10.3892\/mmr.2024.13283"},{"issue":"Suppl 1","key":"1224_CR3","doi-asserted-by":"publisher","first-page":"S98","DOI":"10.1016\/j.clinre.2015.05.018","volume":"39","author":"A Masamune","year":"2015","unstructured":"Masamune A, Shimosegawa T (2015) Pancreatic stellate cells: A dynamic player of the intercellular communication in pancreatic cancer. Clin Res Hepatol Gastroenterol 39(Suppl 1):S98\u2013103. https:\/\/doi.org\/10.1016\/j.clinre.2015.05.018","journal-title":"Clin Res Hepatol Gastroenterol"},{"key":"1224_CR4","doi-asserted-by":"publisher","first-page":"6352","DOI":"10.1038\/s41598-020-63433-6","volume":"10","author":"A Gonzalez","year":"2020","unstructured":"Gonzalez A, Estaras M, Martinez-Morcillo S et al (2020) Melatonin modulates red-ox state and decreases viability of rat pancreatic stellate cells. Sci Rep 10:6352. https:\/\/doi.org\/10.1038\/s41598-020-63433-6","journal-title":"Sci Rep"},{"key":"1224_CR5","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1111\/boc.202000020","volume":"112","author":"M Estaras","year":"2020","unstructured":"Estaras M, Martinez-Morcillo S, Garc\u00eda A et al (2020) Pancreatic stellate cells exhibit adaptation to oxidative stress evoked by hypoxia. Biol cell 112:280\u2013299. https:\/\/doi.org\/10.1111\/boc.202000020","journal-title":"Biol cell"},{"key":"1224_CR6","doi-asserted-by":"publisher","unstructured":"Ortiz-Plac\u00edn C, Castillejo-Rufo A, Estar\u00e1s M, Gonz\u00e1lez A (2023) Membrane lipid derivatives: roles of arachidonic acid and its metabolites in pancreatic physiology and pathophysiology. Molecules 28. https:\/\/doi.org\/10.3390\/molecules28114316","DOI":"10.3390\/molecules28114316"},{"key":"1224_CR7","doi-asserted-by":"publisher","first-page":"10729","DOI":"10.3748\/wjg.v20.i31.10729","volume":"20","author":"LM Knab","year":"2014","unstructured":"Knab LM, Grippo PJ, Bentrem DJ (2014) Involvement of eicosanoids in the pathogenesis of pancreatic cancer: the roles of cyclooxygenase-2 and 5-lipoxygenase. World J Gastroenterol 20:10729\u201310739. https:\/\/doi.org\/10.3748\/wjg.v20.i31.10729","journal-title":"World J Gastroenterol"},{"key":"1224_CR8","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1016\/j.bbagen.2007.03.002","volume":"1770","author":"GX Zhou","year":"2007","unstructured":"Zhou GX, Ding XL, Huang JF et al (2007) Suppression of 5-lipoxygenase gene is involved in triptolide-induced apoptosis in pancreatic tumor cell lines. Biochim Biophys Acta 1770:1021\u20131027. https:\/\/doi.org\/10.1016\/j.bbagen.2007.03.002","journal-title":"Biochim Biophys Acta"},{"key":"1224_CR9","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/0192-0561(92)90182-k","volume":"14","author":"RL Bell","year":"1992","unstructured":"Bell RL, Young PR, Albert D et al (1992) The discovery and development of zileuton: an orally active 5-lipoxygenase inhibitor. Int J Immunopharmacol 14:505\u2013510. https:\/\/doi.org\/10.1016\/0192-0561(92)90182-k","journal-title":"Int J Immunopharmacol"},{"key":"1224_CR10","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1007\/s00280-021-04343-w","volume":"88","author":"L Li","year":"2021","unstructured":"Li L, Xiao Y, Xu Z, Wang S (2021) Zileuton inhibits arachidonate-5-lipoxygenase to exert antitumor effects in preclinical cervical cancer models. Cancer Chemother Pharmacol 88:953\u2013960. https:\/\/doi.org\/10.1007\/s00280-021-04343-w","journal-title":"Cancer Chemother Pharmacol"},{"key":"1224_CR11","doi-asserted-by":"publisher","first-page":"1452e7","DOI":"10.1016\/j.urology.2013.08.060","volume":"82","author":"Z Meng","year":"2013","unstructured":"Meng Z, Cao R, Yang Z et al (2013) Inhibitor of 5-lipoxygenase, zileuton, suppresses prostate cancer metastasis by upregulating E-cadherin and paxillin. Urology 82:1452e7\u2013145214. https:\/\/doi.org\/10.1016\/j.urology.2013.08.060","journal-title":"Urology"},{"key":"1224_CR12","doi-asserted-by":"publisher","first-page":"106575","DOI":"10.1016\/j.prostaglandins.2021.106575","volume":"156","author":"C Xia","year":"2021","unstructured":"Xia C, Sadeghi L, Str\u00e5\u00e5t K et al (2021) Intrinsic 5-lipoxygenase activity regulates migration and adherence of mantle cell lymphoma cells. Prostaglandins Other Lipid Mediat 156:106575. https:\/\/doi.org\/10.1016\/j.prostaglandins.2021.106575","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"1224_CR13","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1007\/s10565-015-9297-6","volume":"31","author":"P Santofimia-Casta\u00f1o","year":"2015","unstructured":"Santofimia-Casta\u00f1o P, Garcia-Sanchez L, Ruy DC et al (2015) Melatonin induces calcium mobilization and influences cell proliferation independently of MT1\/MT2 receptor activation in rat pancreatic stellate cells. Cell Biol Toxicol 31:95\u2013110. https:\/\/doi.org\/10.1007\/s10565-015-9297-6","journal-title":"Cell Biol Toxicol"},{"key":"1224_CR14","first-page":"9","volume":"1","author":"A Gonzalez","year":"2016","unstructured":"Gonzalez A, Salido GM (2016) Determination of reactive oxygen species production in pancreatic acinar cells. Pancreapedia Exocrine Pancreas Knowl Base 1:9","journal-title":"Pancreapedia Exocrine Pancreas Knowl Base"},{"key":"1224_CR15","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1007\/s13105-019-00671-x","volume":"75","author":"M Estaras","year":"2019","unstructured":"Estaras M, Moreno N, Santofimia-Casta\u00f1o P et al (2019) Melatonin induces reactive oxygen species generation and changes in glutathione levels and reduces viability in human pancreatic stellate cells. J Physiol Biochem 75:185\u2013197. https:\/\/doi.org\/10.1007\/s13105-019-00671-x","journal-title":"J Physiol Biochem"},{"key":"1224_CR16","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1006\/abio.1976.9999","volume":"72","author":"MM Bradford","year":"1976","unstructured":"Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248\u2013254. https:\/\/doi.org\/10.1006\/abio.1976.9999","journal-title":"Anal Biochem"},{"key":"1224_CR17","doi-asserted-by":"publisher","first-page":"115118","DOI":"10.1016\/j.bcp.2022.115118","volume":"202","author":"M Estaras","year":"2022","unstructured":"Estaras M, Martinez R, Garcia A et al (2022) Melatonin modulates metabolic adaptation of pancreatic stellate cells subjected to hypoxia. Biochem Pharmacol 202:115118. https:\/\/doi.org\/10.1016\/j.bcp.2022.115118","journal-title":"Biochem Pharmacol"},{"key":"1224_CR18","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1016\/S0898-6568(03)00067-6","volume":"15","author":"A Gonz\u00e1lez","year":"2003","unstructured":"Gonz\u00e1lez A, Granados MP, Salido GM, Pariente JA (2003) Changes in mitochondrial activity evoked by cholecystokinin in isolated mouse pancreatic acinar cells. Cell Signal 15:1039\u20131048. https:\/\/doi.org\/10.1016\/S0898-6568(03)00067-6","journal-title":"Cell Signal"},{"key":"1224_CR19","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1111\/j.1600-079X.2010.00834.x","volume":"50","author":"A Gonzalez","year":"2011","unstructured":"Gonzalez A, del Castillo-Vaquero A, Miro-Moran A et al (2011) Melatonin reduces pancreatic tumor cell viability by altering mitochondrial physiology. J Pineal Res 50:250\u2013260. https:\/\/doi.org\/10.1111\/j.1600-079X.2010.00834.x","journal-title":"J Pineal Res"},{"key":"1224_CR20","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1111\/boc.202000020","volume":"112","author":"M Estaras","year":"2020","unstructured":"Estaras M, Martinez-Morcillo S, Garc\u00eda A et al (2020) Pancreatic stellate cells exhibit adaptation to oxidative stress evoked by hypoxia. Biol Cell 112:280\u2013299. https:\/\/doi.org\/10.1111\/boc.202000020","journal-title":"Biol Cell"},{"key":"1224_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10059-011-1021-7","volume":"32","author":"K-J Cho","year":"2011","unstructured":"Cho K-J, Seo J-M, Kim J-H (2011) Bioactive lipoxygenase metabolites stimulation of NADPH oxidases and reactive oxygen species. Mol Cells 32:1\u20135. https:\/\/doi.org\/10.1007\/s10059-011-1021-7","journal-title":"Mol Cells"},{"key":"1224_CR22","doi-asserted-by":"publisher","first-page":"8403578","DOI":"10.1155\/2019\/8403578","volume":"2019","author":"M Maciejczyk","year":"2019","unstructured":"Maciejczyk M, Skutnik-Radziszewska A, Zieniewska I et al (2019) Antioxidant Defense, Oxidative Modification, and Salivary Gland Function in an Early Phase of Cerulein Pancreatitis. Oxid Med Cell Longev 2019:8403578. https:\/\/doi.org\/10.1155\/2019\/8403578","journal-title":"Oxid Med Cell Longev"},{"key":"1224_CR23","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.mam.2011.10.006","volume":"32","author":"BM Hybertson","year":"2011","unstructured":"Hybertson BM, Gao B, Bose SK, McCord JM (2011) Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation. Mol Aspects Med 32:234\u2013246. https:\/\/doi.org\/10.1016\/j.mam.2011.10.006","journal-title":"Mol Aspects Med"},{"key":"1224_CR24","doi-asserted-by":"publisher","unstructured":"Estaras M, Gonzalez-Portillo MR, Martinez R et al (2021) Melatonin modulates the antioxidant defenses and the expression of proinflammatory mediators in pancreatic stellate cells subjected to Hypoxia. Antioxid (Basel Switzerland) 10. https:\/\/doi.org\/10.3390\/antiox10040577","DOI":"10.3390\/antiox10040577"},{"key":"1224_CR25","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.freeradbiomed.2009.05.018","volume":"47","author":"L Miao","year":"2009","unstructured":"Miao L, St Clair DK (2009) Regulation of superoxide dismutase genes: implications in disease. Free Radic Biol Med 47:344\u2013356. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2009.05.018","journal-title":"Free Radic Biol Med"},{"key":"1224_CR26","doi-asserted-by":"publisher","first-page":"7864150","DOI":"10.1155\/2016\/7864150","volume":"2016","author":"Z Dong","year":"2016","unstructured":"Dong Z, Shang H, Chen YQ et al (2016) Sulforaphane Protects Pancreatic Acinar Cell Injury by Modulating Nrf2-Mediated Oxidative Stress and NLRP3 Inflammatory Pathway. Oxid Med Cell Longev 2016:7864150. https:\/\/doi.org\/10.1155\/2016\/7864150","journal-title":"Oxid Med Cell Longev"},{"key":"1224_CR27","doi-asserted-by":"publisher","first-page":"2026","DOI":"10.1097\/CM9.0000000000002096","volume":"135","author":"H Li","year":"2022","unstructured":"Li H, Lin Y, Zhang L et al (2022) Ferroptosis and its emerging roles in acute pancreatitis. Chin Med J (Engl) 135:2026\u20132034. https:\/\/doi.org\/10.1097\/CM9.0000000000002096","journal-title":"Chin Med J (Engl)"},{"key":"1224_CR28","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1007\/s13238-020-00789-5","volume":"12","author":"P Koppula","year":"2021","unstructured":"Koppula P, Zhuang L, Gan B (2021) Cystine transporter SLC7A11\/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy. Protein Cell 12:599\u2013620. https:\/\/doi.org\/10.1007\/s13238-020-00789-5","journal-title":"Protein Cell"},{"key":"1224_CR29","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1007\/s12264-020-00620-5","volume":"37","author":"Y Cao","year":"2021","unstructured":"Cao Y, Li Y, He C et al (2021) Selective Ferroptosis Inhibitor Liproxstatin-1 Attenuates Neurological Deficits and Neuroinflammation After Subarachnoid Hemorrhage. Neurosci Bull 37:535\u2013549. https:\/\/doi.org\/10.1007\/s12264-020-00620-5","journal-title":"Neurosci Bull"},{"key":"1224_CR30","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1038\/s41419-023-05779-z","volume":"14","author":"J Hao","year":"2023","unstructured":"Hao J, Chen Q, Feng Y et al (2023) Combination treatment with FAAH inhibitors\/URB597 and ferroptosis inducers significantly decreases the growth and metastasis of renal cell carcinoma cells via the PI3K-AKT signaling pathway. Cell Death Dis 14:247. https:\/\/doi.org\/10.1038\/s41419-023-05779-z","journal-title":"Cell Death Dis"},{"key":"1224_CR31","doi-asserted-by":"publisher","first-page":"100020","DOI":"10.1016\/j.metop.2019.100020","volume":"4","author":"JFE Grey","year":"2019","unstructured":"Grey JFE, Townley AR, Everitt NM et al (2019) A cost-effective, analytical method for measuring metabolic load of mitochondria. Metab open 4:100020. https:\/\/doi.org\/10.1016\/j.metop.2019.100020","journal-title":"Metab open"},{"key":"1224_CR32","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1007\/s11010-005-3457-6","volume":"269","author":"A Gonz\u00e1lez","year":"2005","unstructured":"Gonz\u00e1lez A, Granados MP, Salido GM, Pariente JA (2005) H2O2-induced changes in mitochondrial activity in isolated mouse pancreatic acinar cells. Mol Cell Biochem 269:165\u2013173. https:\/\/doi.org\/10.1007\/s11010-005-3457-6","journal-title":"Mol Cell Biochem"},{"key":"1224_CR33","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1042\/EBC20190083","volume":"64","author":"PC Calder","year":"2020","unstructured":"Calder PC (2020) Eicosanoids Essays Biochem 64:423\u2013441. https:\/\/doi.org\/10.1042\/EBC20190083","journal-title":"Eicosanoids Essays Biochem"},{"key":"1224_CR34","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1093\/oxfordjournals.jbchem.a003101","volume":"131","author":"M Murakami","year":"2002","unstructured":"Murakami M, Kudo I (2002) Phospholipase A2. J Biochem 131:285\u2013292. https:\/\/doi.org\/10.1093\/oxfordjournals.jbchem.a003101","journal-title":"J Biochem"},{"key":"1224_CR35","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.addr.2020.06.028","volume":"159","author":"A Leuti","year":"2020","unstructured":"Leuti A, Fazio D, Fava M et al (2020) Bioactive lipids, inflammation and chronic diseases. Adv Drug Deliv Rev 159:133\u2013169. https:\/\/doi.org\/10.1016\/j.addr.2020.06.028","journal-title":"Adv Drug Deliv Rev"},{"key":"1224_CR36","doi-asserted-by":"publisher","first-page":"1813","DOI":"10.1053\/j.gastro.2021.09.059","volume":"161","author":"D Wang","year":"2021","unstructured":"Wang D, Cabalag CS, Clemons NJ, DuBois RN (2021) Cyclooxygenases and Prostaglandins in Tumor Immunology and Microenvironment of Gastrointestinal Cancer. Gastroenterology 161:1813\u20131829. https:\/\/doi.org\/10.1053\/j.gastro.2021.09.059","journal-title":"Gastroenterology"},{"key":"1224_CR37","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.2174\/0929867326666191210104820","volume":"28","author":"M Mahboubi-Rabbani","year":"2021","unstructured":"Mahboubi-Rabbani M, Zarghi A (2021) Lipoxygenase Inhibitors as Cancer Chemopreventives: Discovery, Recent Developments and Future Perspectives. Curr Med Chem 28:1143\u20131175. https:\/\/doi.org\/10.2174\/0929867326666191210104820","journal-title":"Curr Med Chem"},{"key":"1224_CR38","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1038\/s41388-024-03016-1","volume":"43","author":"AS Kahnt","year":"2024","unstructured":"Kahnt AS, H\u00e4fner A-K, Steinhilber D (2024) The role of human 5-Lipoxygenase (5-LO) in carcinogenesis - a question of canonical and non-canonical functions. Oncogene 43:1319\u20131327. https:\/\/doi.org\/10.1038\/s41388-024-03016-1","journal-title":"Oncogene"},{"key":"1224_CR39","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1146\/annurev-cellbio-100617-062855","volume":"34","author":"MH Sherman","year":"2018","unstructured":"Sherman MH (2018) Stellate Cells in Tissue Repair, Inflammation, and Cancer. Annu Rev Cell Dev Biol 34:333\u2013355. https:\/\/doi.org\/10.1146\/annurev-cellbio-100617-062855","journal-title":"Annu Rev Cell Dev Biol"},{"key":"1224_CR40","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1080\/17474124.2024.2355969","volume":"18","author":"S Iyer","year":"2024","unstructured":"Iyer S, Enman M, Sahay P, Dudeja V (2024) Novel therapeutics to treat chronic pancreatitis: targeting pancreatic stellate cells and macrophages. Expert Rev Gastroenterol Hepatol 18:171\u2013183. https:\/\/doi.org\/10.1080\/17474124.2024.2355969","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"1224_CR41","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.cell.2014.08.007","volume":"159","author":"MH Sherman","year":"2014","unstructured":"Sherman MH, Yu RT, Engle DD et al (2014) Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy. Cell 159:80\u201393. https:\/\/doi.org\/10.1016\/j.cell.2014.08.007","journal-title":"Cell"},{"key":"1224_CR42","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1152\/physrev.00044.2023","volume":"105","author":"J Sastre","year":"2025","unstructured":"Sastre J, P\u00e9rez S, Sabater L, Rius-P\u00e9rez S (2025) Redox signaling in the pancreas in health and disease. Physiol Rev 105:593\u2013650. https:\/\/doi.org\/10.1152\/physrev.00044.2023","journal-title":"Physiol Rev"},{"key":"1224_CR43","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1007\/s13105-020-00740-6","volume":"76","author":"M Estaras","year":"2020","unstructured":"Estaras M, Pe\u00f1a FJ, Tapia JA et al (2020) Melatonin modulates proliferation of pancreatic stellate cells through caspase-3 activation and changes in cyclin A and D expression. J Physiol Biochem 76:345\u2013355. https:\/\/doi.org\/10.1007\/s13105-020-00740-6","journal-title":"J Physiol Biochem"},{"key":"1224_CR44","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1007\/s13105-022-00930-4","volume":"79","author":"M Estaras","year":"2023","unstructured":"Estaras M, Ortiz-Placin C, Castillejo-Rufo A et al (2023) Melatonin controls cell proliferation and modulates mitochondrial physiology in pancreatic stellate cells. J Physiol Biochem 79:235\u2013249. https:\/\/doi.org\/10.1007\/s13105-022-00930-4","journal-title":"J Physiol Biochem"},{"key":"1224_CR45","doi-asserted-by":"publisher","first-page":"e2000027","DOI":"10.1002\/ardp.202000027","volume":"353","author":"MA Shaaban","year":"2020","unstructured":"Shaaban MA, Kamal AM, Faggal SI et al (2020) Design, synthesis, and biological evaluation of new pyrazoloquinazoline derivatives as dual COX-2\/5-LOX inhibitors. Arch Pharm (Weinheim) 353:e2000027. https:\/\/doi.org\/10.1002\/ardp.202000027","journal-title":"Arch Pharm (Weinheim)"},{"key":"1224_CR46","first-page":"283","volume":"48","author":"K Czubowicz","year":"2010","unstructured":"Czubowicz K, Czapski GA, Cie\u015blik M, Strosznajder RP (2010) Lipoxygenase inhibitors protect brain cortex macromolecules against oxidation evoked by nitrosative stress. Folia Neuropathol 48:283\u2013292","journal-title":"Folia Neuropathol"},{"key":"1224_CR47","doi-asserted-by":"publisher","first-page":"7019","DOI":"10.2147\/OTT.S178942","volume":"11","author":"S Khophai","year":"2018","unstructured":"Khophai S, Thanee M, Techasen A et al (2018) Zileuton suppresses cholangiocarcinoma cell proliferation and migration through inhibition of the Akt signaling pathway. Onco Targets Ther 11:7019\u20137029. https:\/\/doi.org\/10.2147\/OTT.S178942","journal-title":"Onco Targets Ther"},{"key":"1224_CR48","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.molcel.2018.10.042","volume":"73","author":"M Gao","year":"2019","unstructured":"Gao M, Yi J, Zhu J et al (2019) Role of Mitochondria in Ferroptosis. Mol Cell 73:354\u2013363. https:\/\/doi.org\/10.1016\/j.molcel.2018.10.042. .e3","journal-title":"Mol Cell"},{"key":"1224_CR49","doi-asserted-by":"publisher","unstructured":"Fujii J, Imai H (2024) Oxidative metabolism as a cause of lipid peroxidation in the execution of ferroptosis. Int J Mol Sci 25. https:\/\/doi.org\/10.3390\/ijms25147544","DOI":"10.3390\/ijms25147544"}],"container-title":["Journal of Physiology and Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13105-026-01224-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13105-026-01224-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13105-026-01224-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T05:01:07Z","timestamp":1789534867000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13105-026-01224-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,16]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["1224"],"URL":"https:\/\/doi.org\/10.1007\/s13105-026-01224-9","relation":{},"ISSN":["1138-7548","1877-8755"],"issn-type":[{"value":"1138-7548","type":"print"},{"value":"1877-8755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,16]]},"assertion":[{"value":"23 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Neither generative AI nor AI-assisted technologies were used in the writing of this manuscript","order":1,"name":"Ethics","label":"Generative Ai and Ai-assisted technologies in the manuscript preparation process","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that there is no conflict of interest.","order":2,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"93"}}