{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T14:21:46Z","timestamp":1788272506154,"version":"build-2803163510"},"reference-count":256,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China grants","doi-asserted-by":"crossref","award":["82473058"],"award-info":[{"award-number":["82473058"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Physiol Biochem"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s13105-026-01228-5","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T13:59:33Z","timestamp":1788271173000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Potassium channels in cancer: from hallmarks to therapeutic targeting"],"prefix":"10.1007","volume":"82","author":[{"given":"Yi-ling","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong-jia","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-hua","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"1228_CR1","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/s0092-8674(00)81683-9","volume":"100","author":"D Hanahan","year":"2000","unstructured":"Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100:57\u201370. https:\/\/doi.org\/10.1016\/s0092-8674(00)81683-9","journal-title":"Cell"},{"key":"1228_CR2","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","volume":"144","author":"D Hanahan","year":"2011","unstructured":"Hanahan D, Weinberg RA (2011) Hallmarks of cancer: The next generation. Cell 144:646\u2013674. https:\/\/doi.org\/10.1016\/j.cell.2011.02.013","journal-title":"Cell"},{"key":"1228_CR3","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1158\/2159-8290.CD-21-1059","volume":"12","author":"D Hanahan","year":"2022","unstructured":"Hanahan D (2022) Hallmarks of Cancer: New Dimensions. Cancer Discov 12:31\u201346. https:\/\/doi.org\/10.1158\/2159-8290.CD-21-1059","journal-title":"Cancer Discov"},{"key":"1228_CR4","doi-asserted-by":"publisher","first-page":"2254","DOI":"10.1016\/j.cell.2025.12.049","volume":"189","author":"D Hanahan","year":"2026","unstructured":"Hanahan D (2026) Hallmarks of cancer\u2014then and now, and beyond. Cell 189:2254\u20132277. https:\/\/doi.org\/10.1016\/j.cell.2025.12.049","journal-title":"Cell"},{"key":"1228_CR5","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.tips.2025.11.010","volume":"47","author":"WL Liu","year":"2026","unstructured":"Liu WL, Xie X, Chen H et al (2026) Targeting ion channel dysregulation in tumors: emerging therapeutic opportunities. Trends Pharmacol Sci 47:131\u2013154. https:\/\/doi.org\/10.1016\/j.tips.2025.11.010","journal-title":"Trends Pharmacol Sci"},{"key":"1228_CR6","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1038\/nrc3635","volume":"14","author":"LA Pardo","year":"2014","unstructured":"Pardo LA, St\u00fchmer W (2014) The roles of K+ channels in cancer. Nat Rev Cancer 14:39\u201348. https:\/\/doi.org\/10.1038\/nrc3635","journal-title":"Nat Rev Cancer"},{"key":"1228_CR7","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1083\/jcb.201404136","volume":"206","author":"X Huang","year":"2014","unstructured":"Huang X, Jan LY (2014) Targeting potassium channels in cancer. J Cell Biol 206:151\u2013162. https:\/\/doi.org\/10.1083\/jcb.201404136","journal-title":"J Cell Biol"},{"key":"1228_CR8","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1038\/nrn1988","volume":"7","author":"LK Kaczmarek","year":"2006","unstructured":"Kaczmarek LK (2006) Non-conducting functions of voltage-gated ion channels. Nat Rev Neurosci 7:761\u2013771. https:\/\/doi.org\/10.1038\/nrn1988","journal-title":"Nat Rev Neurosci"},{"key":"1228_CR9","doi-asserted-by":"publisher","first-page":"135","DOI":"10.4149\/neo_2020_200629N667","volume":"68","author":"X Lu","year":"2021","unstructured":"Lu X, Li K, Yang J (2021) Potassium voltage-gated channel subfamily D member 2 induces an aggressive phenotype in lung adenocarcinoma. Neoplasma 68:135\u2013143. https:\/\/doi.org\/10.4149\/neo_2020_200629N667","journal-title":"Neoplasma"},{"key":"1228_CR10","doi-asserted-by":"publisher","first-page":"102384","DOI":"10.1016\/j.ceca.2021.102384","volume":"96","author":"S Ibrahim","year":"2021","unstructured":"Ibrahim S, Chaigne J, Dakik H et al (2021) SK4 oncochannels regulate calcium entry and promote cell migration in KRAS-mutated colorectal cancer. Cell Calcium 96:102384. https:\/\/doi.org\/10.1016\/j.ceca.2021.102384","journal-title":"Cell Calcium"},{"key":"1228_CR11","doi-asserted-by":"publisher","first-page":"2309","DOI":"10.1038\/s41598-024-52739-4","volume":"14","author":"HJ Sim","year":"2024","unstructured":"Sim HJ, Kim MR, Song MS, Lee SY (2024) Kv3.4 regulates cell migration and invasion through TGF-\u03b2-induced epithelial-mesenchymal transition in A549 cells. Sci Rep 14:2309. https:\/\/doi.org\/10.1038\/s41598-024-52739-4","journal-title":"Sci Rep"},{"key":"1228_CR12","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1007\/s10142-023-01183-0","volume":"23","author":"S Yang","year":"2023","unstructured":"Yang S, Zhou P, Qi L et al (2023) Promoting proliferation and tumorigenesis of breast cancer: KCND2\u2019s significance as a prognostic factor. Funct Integr Genomics 23:257. https:\/\/doi.org\/10.1007\/s10142-023-01183-0","journal-title":"Funct Integr Genomics"},{"key":"1228_CR13","doi-asserted-by":"publisher","first-page":"18608","DOI":"10.1038\/s41598-023-45074-7","volume":"13","author":"Q Zhao","year":"2023","unstructured":"Zhao Q, Li M, Zhang Y (2023) Comprehensive pan\u2013cancer analysis of potassium voltage-gated channel Q4 (KCNQ4) gene across multiple human malignant tumors. Sci Rep 13:18608. https:\/\/doi.org\/10.1038\/s41598-023-45074-7","journal-title":"Sci Rep"},{"key":"1228_CR14","doi-asserted-by":"publisher","first-page":"102030","DOI":"10.1016\/j.redox.2021.102030","volume":"45","author":"V Senyuk","year":"2021","unstructured":"Senyuk V, Eskandari N, Jiang Y et al (2021) Compensatory expression of NRF2-dependent antioxidant genes is required to overcome the lethal effects of Kv11.1 activation in breast cancer cells and PDOs. Redox Biol 45:102030. https:\/\/doi.org\/10.1016\/j.redox.2021.102030","journal-title":"Redox Biol"},{"key":"1228_CR15","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1111\/bph.13357","volume":"173","author":"ZA Abdulkareem","year":"2016","unstructured":"Abdulkareem ZA, Gee JM, Cox CD, Wann KT (2016) Knockdown of the small conductance Ca2+-activated K+ channels is potently cytotoxic in breast cancer cell lines. Br J Pharmacol 173:177\u2013190. https:\/\/doi.org\/10.1111\/bph.13357","journal-title":"Br J Pharmacol"},{"key":"1228_CR16","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1186\/s12920-022-01351-4","volume":"15","author":"B Li","year":"2022","unstructured":"Li B, Ge N, Pan Z et al (2022) KCNJ14 knockdown significantly inhibited the proliferation and migration of colorectal cells. BMC Med Genomics 15:194. https:\/\/doi.org\/10.1186\/s12920-022-01351-4","journal-title":"BMC Med Genomics"},{"key":"1228_CR17","doi-asserted-by":"publisher","first-page":"848","DOI":"10.3389\/fphar.2020.00848","volume":"11","author":"J Iorio","year":"2020","unstructured":"Iorio J, Duranti C, Lottini T et al (2020) KV11.1 potassium channel and the Na+\/H+ antiporter NHE1 modulate adhesion-dependent intracellular pH in colorectal cancer cells. Front Pharmacol 11:848 https:\/\/doi.org\/10.3389\/fphar.2020.00848","journal-title":"Front Pharmacol"},{"key":"1228_CR18","doi-asserted-by":"publisher","first-page":"254","DOI":"10.2337\/diacare.29.02.06.dc05-1558","volume":"29","author":"SL Bowker","year":"2006","unstructured":"Bowker SL, Majumdar SR, Veugelers P, Johnson JA (2006) Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin. Diabetes Care 29:254\u2013258. https:\/\/doi.org\/10.2337\/diacare.29.02.06.dc05-1558","journal-title":"Diabetes Care"},{"key":"1228_CR19","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1007\/s00592-008-0083-2","volume":"46","author":"M Monami","year":"2009","unstructured":"Monami M, Lamanna C, Balzi D et al (2009) Sulphonylureas and cancer: A case\u2013control study. Acta Diabetol 46:279\u2013284. https:\/\/doi.org\/10.1007\/s00592-008-0083-2","journal-title":"Acta Diabetol"},{"key":"1228_CR20","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1080\/13543784.2017.1333104","volume":"26","author":"R Gao","year":"2017","unstructured":"Gao R, Yang T, Xu W (2017) Enemies or weapons in hands: Investigational anti-diabetic drug glibenclamide and cancer risk. Expert Opin Investig Drugs 26:853\u2013864. https:\/\/doi.org\/10.1080\/13543784.2017.1333104","journal-title":"Expert Opin Investig Drugs"},{"key":"1228_CR21","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1158\/1078-0432.CCR-15-3169","volume":"23","author":"KB Pointer","year":"2017","unstructured":"Pointer KB, Clark PA, Eliceiri KW et al (2017) Administration of non-torsadogenic human ether-\u00e0-go-go-related gene inhibitors is associated with better survival for high hERG\u2013expressing glioblastoma patients. Clin Cancer Res 23:73\u201380. https:\/\/doi.org\/10.1158\/1078-0432.CCR-15-3169","journal-title":"Clin Cancer Res"},{"key":"1228_CR22","doi-asserted-by":"publisher","first-page":"129905","DOI":"10.1016\/j.molstruc.2021.129905","volume":"1230","author":"A Teisseyre","year":"2021","unstructured":"Teisseyre A, Uryga A, Michalak K (2021) Statins as inhibitors of voltage-gated potassium channels Kv1.3 in cancer cells. J Mol Struct 1230:129905. https:\/\/doi.org\/10.1016\/j.molstruc.2021.129905","journal-title":"J Mol Struct"},{"key":"1228_CR23","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1007\/s10552-024-01939-4","volume":"36","author":"H Guo","year":"2025","unstructured":"Guo H, Malone KE, Heckbert SR, Li CI (2025) Statin use after cancer diagnosis and survival among patients with cancer. Cancer Causes Control 36:443\u2013455. https:\/\/doi.org\/10.1007\/s10552-024-01939-4","journal-title":"Cancer Causes Control"},{"key":"1228_CR24","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1126\/science.280.5360.69","volume":"280","author":"DA Doyle","year":"1998","unstructured":"Doyle DA, Morais Cabral J, Pfuetzner RA et al (1998) The structure of the potassium channel: molecular basis of K+ conduction and selectivity. Science 280:69\u201377. https:\/\/doi.org\/10.1126\/science.280.5360.69","journal-title":"Science"},{"key":"1228_CR25","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-015-1948-5","author":"Q Kuang","year":"2015","unstructured":"Kuang Q, Purhonen P, Hebert H (2015) Structure of potassium channels. Cell Mol Life Sci72:3677\u20133693 https:\/\/doi.org\/10.1007\/s00018-015-1948-5","journal-title":"Cell Mol Life Sci"},{"key":"1228_CR26","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1038\/35102009","volume":"414","author":"Y Zhou","year":"2001","unstructured":"Zhou Y, Morais-Cabral JH, Kaufman A, MacKinnon R (2001) Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 A resolution. Nature 414:43\u201348. https:\/\/doi.org\/10.1038\/35102009","journal-title":"Nature"},{"key":"1228_CR27","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1038\/35102000","volume":"414","author":"JH Morais-Cabral","year":"2001","unstructured":"Morais-Cabral JH, Zhou Y, MacKinnon R (2001) Energetic optimization of ion conduction rate by the K+ selectivity filter. Nature 414:37\u201342. https:\/\/doi.org\/10.1038\/35102000","journal-title":"Nature"},{"key":"1228_CR28","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1152\/physiol.00005.2022","volume":"37","author":"GW Abbott","year":"2022","unstructured":"Abbott GW (2022) Kv Channel Ancillary Subunits: Where Do We Go from Here? Physiology 37:225\u2013241. https:\/\/doi.org\/10.1152\/physiol.00005.2022","journal-title":"Physiology"},{"issue":"Suppl 2","key":"1228_CR29","doi-asserted-by":"publisher","first-page":"S145","DOI":"10.1111\/bph.16178","volume":"180","author":"SPH Alexander","year":"2023","unstructured":"Alexander SPH, Mathie AA, Peters JA et al (2023) The concise guide to PHARMACOLOGY 2023\/24: Ion channels. Br J Pharmacol 180(Suppl 2):S145\u2013S222. https:\/\/doi.org\/10.1111\/bph.16178","journal-title":"Br J Pharmacol"},{"key":"1228_CR30","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1038\/nature00978","volume":"419","author":"G Yellen","year":"2002","unstructured":"Yellen G (2002) The voltage-gated potassium channels and their relatives. Nature 419:35\u201342. https:\/\/doi.org\/10.1038\/nature00978","journal-title":"Nature"},{"key":"1228_CR31","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1038\/nrd2983","volume":"8","author":"H Wulff","year":"2009","unstructured":"Wulff H, Castle NA, Pardo LA (2009) Voltage-gated potassium channels as therapeutic targets. Nat Rev Drug Discov 8:982\u20131001. https:\/\/doi.org\/10.1038\/nrd2983","journal-title":"Nat Rev Drug Discov"},{"key":"1228_CR32","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1124\/pr.57.4.10","volume":"57","author":"GA Gutman","year":"2005","unstructured":"Gutman GA, Chandy KG, Grissmer S et al (2005) International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. Pharmacol Rev 57:473\u2013508 https:\/\/doi.org\/10.1124\/pr.57.4.10","journal-title":"Pharmacol Rev"},{"key":"1228_CR33","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1038\/nrn1244","volume":"4","author":"D Bichet","year":"2003","unstructured":"Bichet D, Haass FA, Jan LY (2003) Merging functional studies with structures of inward-rectifier K(+) channels. Nat Rev Neurosci 4:957\u2013967. https:\/\/doi.org\/10.1038\/nrn1244","journal-title":"Nat Rev Neurosci"},{"key":"1228_CR34","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1152\/physrev.00021.2009","volume":"90","author":"H Hibino","year":"2010","unstructured":"Hibino H, Inanobe A, Furutani K et al (2010) Inwardly rectifying potassium channels: Their structure, function, and physiological roles. Physiol Rev 90:291\u2013366. https:\/\/doi.org\/10.1152\/physrev.00021.2009","journal-title":"Physiol Rev"},{"key":"1228_CR35","doi-asserted-by":"publisher","first-page":"160","DOI":"10.54254\/2753-8818\/62\/20241522","volume":"62","author":"X Chen","year":"2024","unstructured":"Chen X (2024) Research progress on calcium-activated potassium ion channels. TNS 62:160\u2013165. https:\/\/doi.org\/10.54254\/2753-8818\/62\/20241522","journal-title":"TNS"},{"key":"1228_CR36","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/s0959-4388(98)80056-1","volume":"8","author":"C Vergara","year":"1998","unstructured":"Vergara C, Latorre R, Marrion NV, Adelman JP (1998) Calcium-activated potassium channels. Curr Opin Neurobiol 8:321\u2013329. https:\/\/doi.org\/10.1016\/s0959-4388(98)80056-1","journal-title":"Curr Opin Neurobiol"},{"key":"1228_CR37","doi-asserted-by":"publisher","first-page":"5096","DOI":"10.1073\/pnas.0600907103","volume":"103","author":"JP Morrow","year":"2006","unstructured":"Morrow JP, Zakharov SI, Liu G et al (2006) Defining the BK channel domains required for \u03b21-subunit modulation. Proc Natl Acad Sci U S A 103:5096\u20135101. https:\/\/doi.org\/10.1073\/pnas.0600907103","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1228_CR38","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1038\/nature09252","volume":"466","author":"Y Wu","year":"2010","unstructured":"Wu Y, Yang Y, Ye S, Jiang Y (2010) Structure of the gating ring from the human large-conductance Ca2+-gated K+ channel. Nature 466:393\u2013397. https:\/\/doi.org\/10.1038\/nature09252","journal-title":"Nature"},{"key":"1228_CR39","doi-asserted-by":"publisher","first-page":"3594","DOI":"10.1038\/emboj.2011.230","volume":"30","author":"SN Bagriantsev","year":"2011","unstructured":"Bagriantsev SN, Peyronnet R, Clark KA et al (2011) Multiple modalities converge on a common gate to control K2P channel function. EMBO J 30:3594\u20133606. https:\/\/doi.org\/10.1038\/emboj.2011.230","journal-title":"EMBO J"},{"key":"1228_CR40","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.tips.2005.05.003","volume":"26","author":"SD Buckingham","year":"2005","unstructured":"Buckingham SD, Kidd JF, Law RJ et al (2005) Structure and function of two-pore-domain K+ channels: Contributions from genetic model organisms. Trends Pharmacol Sci 26:361\u2013367. https:\/\/doi.org\/10.1016\/j.tips.2005.05.003","journal-title":"Trends Pharmacol Sci"},{"key":"1228_CR41","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1007\/s00424-014-1638-4","volume":"467","author":"W Gonz\u00e1lez","year":"2015","unstructured":"Gonz\u00e1lez W, Valdebenito B, Caballero J et al (2015) K\u2082p channels in plants and animals. Pflugers Arch 467:1091\u20131104. https:\/\/doi.org\/10.1007\/s00424-014-1638-4","journal-title":"Pflugers Arch"},{"key":"1228_CR42","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1152\/physrev.00029.2009","volume":"90","author":"P Enyedi","year":"2010","unstructured":"Enyedi P, Czirj\u00e1k G (2010) Molecular background of leak K+ currents: Two-pore domain potassium channels. Physiol Rev 90:559\u2013605. https:\/\/doi.org\/10.1152\/physrev.00029.2009","journal-title":"Physiol Rev"},{"key":"1228_CR43","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1038\/nature10238","volume":"475","author":"J Payandeh","year":"2011","unstructured":"Payandeh J, Scheuer T, Zheng N, Catterall WA (2011) The crystal structure of a voltage-gated sodium channel. Nature 475:353\u2013358. https:\/\/doi.org\/10.1038\/nature10238","journal-title":"Nature"},{"key":"1228_CR44","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1016\/j.cell.2007.11.028","volume":"131","author":"DE Clapham","year":"2007","unstructured":"Clapham DE (2007) Calcium signaling. Cell 131:1047\u20131058. https:\/\/doi.org\/10.1016\/j.cell.2007.11.028","journal-title":"Cell"},{"key":"1228_CR45","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1038\/nrn2148","volume":"8","author":"BP Bean","year":"2007","unstructured":"Bean BP (2007) The action potential in mammalian central neurons. Nat Rev Neurosci 8:451\u2013465. https:\/\/doi.org\/10.1038\/nrn2148","journal-title":"Nat Rev Neurosci"},{"key":"1228_CR46","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1007\/s00424-024-02964-7","volume":"476","author":"K-P Pissas","year":"2024","unstructured":"Pissas K-P, Gr\u00fcnder S, Tian Y (2024) Functional expression of the proton sensors ASIC1a, TMEM206, and OGR1 together with BKCa channels is associated with cell volume changes and cell death under strongly acidic conditions in DAOY medulloblastoma cells. Pflugers Arch 476:923\u2013937. https:\/\/doi.org\/10.1007\/s00424-024-02964-7","journal-title":"Pflugers Arch - Eur J Physiol"},{"key":"1228_CR47","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1038\/s42003-022-04077-2","volume":"5","author":"P Quicke","year":"2022","unstructured":"Quicke P, Sun Y, Arias-Garcia M et al (2022) Voltage imaging reveals the dynamic electrical signatures of human breast cancer cells. Commun Biol 5:1178. https:\/\/doi.org\/10.1038\/s42003-022-04077-2","journal-title":"Commun Biol"},{"key":"1228_CR48","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1242\/bio.20135215","volume":"2","author":"F Gacki\u00e8re","year":"2013","unstructured":"Gacki\u00e8re F, Warnier M, Katsogiannou M et al (2013) Functional coupling between large-conductance potassium channels and Cav3.2 voltage-dependent calcium channels participates in prostate cancer cell growth. Biol Open 2:941\u2013951. https:\/\/doi.org\/10.1242\/bio.20135215","journal-title":"Biol Open"},{"key":"1228_CR49","doi-asserted-by":"publisher","first-page":"109268","DOI":"10.1016\/j.abb.2022.109268","volume":"725","author":"H Yin","year":"2022","unstructured":"Yin H, Cheng H, Li P, Yang Z (2022) TRPC6 interacted with KCa1.1 channels to regulate the proliferation and apoptosis of glioma cells. Arch Biochem Biophys 725:109268. https:\/\/doi.org\/10.1016\/j.abb.2022.109268","journal-title":"Arch Biochem Biophys"},{"key":"1228_CR50","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/s0301-0082(03)00090-x","volume":"70","author":"SP Yu","year":"2003","unstructured":"Yu SP (2003) Regulation and critical role of potassium homeostasis in apoptosis. Prog Neurobiol 70:363\u2013386. https:\/\/doi.org\/10.1016\/s0301-0082(03)00090-x","journal-title":"Prog Neurobiol"},{"key":"1228_CR51","doi-asserted-by":"publisher","first-page":"103767","DOI":"10.1016\/j.ebiom.2021.103767","volume":"75","author":"SL Payne","year":"2022","unstructured":"Payne SL, Ram P, Srinivasan DH et al (2022) Potassium channel-driven bioelectric signalling regulates metastasis in triple-negative breast cancer. eBioMedicine 75:103767. https:\/\/doi.org\/10.1016\/j.ebiom.2021.103767","journal-title":"eBioMedicine"},{"key":"1228_CR52","doi-asserted-by":"publisher","first-page":"e1648","DOI":"10.1038\/cddis.2015.23","volume":"6","author":"T Bose","year":"2015","unstructured":"Bose T, Cieslar-Pobuda A, Wiechec E (2015) Role of ion channels in regulating Ca2+ homeostasis during the interplay between immune and cancer cells. Cell Death Dis 6:e1648. https:\/\/doi.org\/10.1038\/cddis.2015.23","journal-title":"Cell Death Dis"},{"key":"1228_CR53","doi-asserted-by":"publisher","first-page":"102780","DOI":"10.1016\/j.coi.2026.102780","volume":"100","author":"K Stauderman","year":"2026","unstructured":"Stauderman K, Hebbar S, Feske S (2026) CRAC channels as targets for immunotherapy. Curr Opin Immunol 100:102780. https:\/\/doi.org\/10.1016\/j.coi.2026.102780","journal-title":"Curr Opin Immunol"},{"key":"1228_CR54","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1152\/physrev.00037.2007","volume":"89","author":"EK Hoffmann","year":"2009","unstructured":"Hoffmann EK, Lambert IH, Pedersen SF (2009) Physiology of cell volume regulation in vertebrates. Physiol Rev 89:193\u2013277. https:\/\/doi.org\/10.1152\/physrev.00037.2007","journal-title":"Physiol Rev"},{"key":"1228_CR55","doi-asserted-by":"publisher","first-page":"2337","DOI":"10.1111\/cas.14079","volume":"110","author":"K Morishita","year":"2019","unstructured":"Morishita K, Watanabe K, Ichijo H (2019) Cell volume regulation in cancer cell migration driven by osmotic water flow. Cancer Sci 110:2337\u20132347. https:\/\/doi.org\/10.1111\/cas.14079","journal-title":"Cancer Sci"},{"key":"1228_CR56","doi-asserted-by":"publisher","first-page":"2886","DOI":"10.1073\/pnas.0505909103","volume":"103","author":"AP Hegle","year":"2006","unstructured":"Hegle AP, Marble DD, Wilson GF (2006) A voltage-driven switch for ion-independent signaling by ether-\u00e0-go-go K+ channels. Proc Natl Acad Sci U S A 103:2886\u20132891. https:\/\/doi.org\/10.1073\/pnas.0505909103","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1228_CR57","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1113\/JP282310","volume":"601","author":"A Arcangeli","year":"2023","unstructured":"Arcangeli A, Duranti C, Iorio J, Lastraioli E (2023) The role of potassium channels in tumours of the gastrointestinal tract: a focus on the human ether-\u00e0\u2010go\u2010go related gene 1 channels. J Physiol 601:1597\u20131610. https:\/\/doi.org\/10.1113\/JP282310","journal-title":"J Physiol"},{"key":"1228_CR58","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1038\/s41392-022-00890-7","volume":"7","author":"Y-X Wang","year":"2022","unstructured":"Wang Y-X, Wu H, Ren Y et al (2022) Elevated Kir2.1\/nuclear N2ICD defines a highly malignant subtype of non-WNT\/SHH medulloblastomas. Sig Transduct Target Ther 7:72. https:\/\/doi.org\/10.1038\/s41392-022-00890-7","journal-title":"Signal Transduct Target Ther"},{"key":"1228_CR59","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1158\/0008-5472.CAN-12-2498","volume":"73","author":"I Lee","year":"2013","unstructured":"Lee I, Lee S-J, Kang TM et al (2013) Unconventional role of the inwardly rectifying potassium channel Kir2.2 as a constitutive activator of RelA in cancer. Cancer Res 73:1056\u20131062. https:\/\/doi.org\/10.1158\/0008-5472.CAN-12-2498","journal-title":"Cancer Res"},{"key":"1228_CR60","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1152\/physrev.00020.2009","volume":"90","author":"O Pongs","year":"2010","unstructured":"Pongs O, Schwarz JR (2010) Ancillary Subunits Associated With Voltage-Dependent K+ Channels. Physiol Rev 90:755\u2013796. https:\/\/doi.org\/10.1152\/physrev.00020.2009","journal-title":"Physiol Rev"},{"key":"1228_CR61","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.ceca.2019.04.005","volume":"80","author":"AS Haworth","year":"2019","unstructured":"Haworth AS, Brackenbury WJ (2019) Emerging roles for multifunctional ion channel auxiliary subunits in cancer. Cell Calcium 80:125\u2013140. https:\/\/doi.org\/10.1016\/j.ceca.2019.04.005","journal-title":"Cell Calcium"},{"key":"1228_CR62","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.cbi.2019.03.023","volume":"305","author":"SM Raph","year":"2019","unstructured":"Raph SM, Bhatnagar A, Nystoriak MA (2019) Biochemical and physiological properties of K+ channel-associated AKR6A (Kv\u03b2) proteins. Chem Biol Interact 305:21\u201327. https:\/\/doi.org\/10.1016\/j.cbi.2019.03.023","journal-title":"Chem Biol Interact"},{"key":"1228_CR63","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s12943-015-0298-0","volume":"14","author":"H Liu","year":"2015","unstructured":"Liu H, Huang J, Peng J et al (2015) Upregulation of the inwardly rectifying potassium channel Kir2.1 (KCNJ2) modulates multidrug resistance of small-cell lung cancer under the regulation of miR-7 and the ras\/MAPK pathway. Mol Cancer 14:59. https:\/\/doi.org\/10.1186\/s12943-015-0298-0","journal-title":"Mol Cancer"},{"key":"1228_CR64","doi-asserted-by":"publisher","first-page":"107874","DOI":"10.1016\/j.pharmthera.2021.107874","volume":"227","author":"V Checchetto","year":"2021","unstructured":"Checchetto V, Leanza L, De Stefani D et al (2021) Mitochondrial K+ channels and their implications for disease mechanisms. Pharmacol Ther 227:107874. https:\/\/doi.org\/10.1016\/j.pharmthera.2021.107874","journal-title":"Pharmacol Ther"},{"key":"1228_CR65","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1038\/s41419-021-03627-6","volume":"12","author":"FL Styles","year":"2021","unstructured":"Styles FL, Al-Owais MM, Scragg JL et al (2021) Kv1.3 voltage-gated potassium channels link cellular respiration to proliferation through a non-conducting mechanism. Cell Death Dis 12:372. https:\/\/doi.org\/10.1038\/s41419-021-03627-6","journal-title":"Cell Death Dis"},{"key":"1228_CR66","doi-asserted-by":"publisher","first-page":"5253","DOI":"10.1158\/0008-5472.CAN-12-3690","volume":"73","author":"H Lallet-Daher","year":"2013","unstructured":"Lallet-Daher H, Wiel C, Gitenay D et al (2013) Potassium channel KCNA1 modulates oncogene-induced senescence and transformation. Cancer Res 73:5253\u20135265. https:\/\/doi.org\/10.1158\/0008-5472.CAN-12-3690","journal-title":"Cancer Res"},{"key":"1228_CR67","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s12935-023-03199-9","volume":"24","author":"W Wang","year":"2024","unstructured":"Wang W, Zhang Y, Li X et al (2024) KCNA1 promotes the growth and invasion of glioblastoma cells through ferroptosis inhibition via upregulating SLC7A11. Cancer Cell Int 24:7. https:\/\/doi.org\/10.1186\/s12935-023-03199-9","journal-title":"Cancer Cell Int"},{"key":"1228_CR68","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1186\/s12964-024-01981-4","volume":"22","author":"M Dupuy","year":"2024","unstructured":"Dupuy M, Postec A, Mullard M et al (2024) Transcriptional regulation of KCNA2 coding Kv1.2 by EWS::FLI1: involvement in controlling the YAP\/hippo signalling pathway and cell proliferation. Cell Commun Signal 22:602. https:\/\/doi.org\/10.1186\/s12964-024-01981-4","journal-title":"Cell Commun Signal"},{"key":"1228_CR69","doi-asserted-by":"publisher","first-page":"e69099","DOI":"10.7554\/eLife.69099","volume":"10","author":"J Capera","year":"2021","unstructured":"Capera J, P\u00e9rez-Verdaguer M, Peruzzo R et al (2021) A novel mitochondrial Kv1.3\u2013caveolin axis controls cell survival and apoptosis. eLife 10:e69099. https:\/\/doi.org\/10.7554\/eLife.69099","journal-title":"eLife"},{"key":"1228_CR70","doi-asserted-by":"publisher","first-page":"4591","DOI":"10.1038\/onc.2014.384","volume":"34","author":"KE Ryland","year":"2015","unstructured":"Ryland KE, Svoboda LK, Vesely ED et al (2015) Polycomb-dependent repression of the potassium channel-encoding gene KCNA5 promotes cancer cell survival under conditions of stress. Oncogene 34:4591\u20134600. https:\/\/doi.org\/10.1038\/onc.2014.384","journal-title":"Oncogene"},{"key":"1228_CR71","doi-asserted-by":"publisher","first-page":"130","DOI":"10.5483\/BMBRep.2021.54.2.210","volume":"54","author":"HW Park","year":"2021","unstructured":"Park HW, Song MS, Sim HJ et al (2021) The role of the voltage-gated potassium channel, Kv2.1 in prostate cancer cell migration. BMB Rep 54:130\u2013135. https:\/\/doi.org\/10.5483\/BMBRep.2021.54.2.210","journal-title":"BMB Rep"},{"key":"1228_CR72","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.bbrc.2021.03.019","volume":"551","author":"HJ Sim","year":"2021","unstructured":"Sim HJ, Song MS, Lee SY (2021) Kv3 channels contribute to cancer cell migration via vimentin regulation. Biochem Biophys Res Commun 551:140\u2013147. https:\/\/doi.org\/10.1016\/j.bbrc.2021.03.019","journal-title":"Biochem Biophys Res Commun"},{"key":"1228_CR73","doi-asserted-by":"publisher","first-page":"151678","DOI":"10.1016\/j.bbrc.2025.151678","volume":"760","author":"HJ Sim","year":"2025","unstructured":"Sim HJ, Seo YW, Kim MR et al (2025) Bisphenol a enhanced cell migration through Kv3.4 in MCF7 cells. Biochem Biophys Res Commun 760:151678. https:\/\/doi.org\/10.1016\/j.bbrc.2025.151678","journal-title":"Biochem Biophys Res Commun"},{"key":"1228_CR74","doi-asserted-by":"publisher","first-page":"16279","DOI":"10.1002\/cam4.6236","volume":"12","author":"H Zhou","year":"2023","unstructured":"Zhou H, Su D, Chen Y et al (2023) KCND2: A prognostic biomarker and regulator of immune function in gastric cancer. Cancer Med 12:16279\u201316294. https:\/\/doi.org\/10.1002\/cam4.6236","journal-title":"Cancer Med"},{"key":"1228_CR75","doi-asserted-by":"publisher","first-page":"8086","DOI":"10.18632\/aging.205806","volume":"16","author":"Y Ren","year":"2024","unstructured":"Ren Y, Feng L, Tan Z et al (2024) Constructing a novel prognostic model for triple-negative breast cancer based on genes associated with vasculogenic mimicry. Aging 16:8086\u20138109. https:\/\/doi.org\/10.18632\/aging.205806","journal-title":"Aging"},{"key":"1228_CR76","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1038\/s41417-022-00560-4","volume":"30","author":"C-Y Chen","year":"2023","unstructured":"Chen C-Y, Wu P-Y, Van Scoyk M et al (2023) KCNF1 promotes lung cancer by modulating ITGB4 expression. Cancer Gene Ther 30:414\u2013423. https:\/\/doi.org\/10.1038\/s41417-022-00560-4","journal-title":"Cancer Gene Ther"},{"key":"1228_CR77","doi-asserted-by":"publisher","first-page":"8132","DOI":"10.18632\/oncotarget.3517","volume":"6","author":"J-H Lee","year":"2015","unstructured":"Lee J-H, Park J-W, Byun JK et al (2015) Silencing of voltage-gated potassium channel KV9.3 inhibits proliferation in human colon and lung carcinoma cells. Oncotarget 6:8132\u20138143. https:\/\/doi.org\/10.18632\/oncotarget.3517","journal-title":"Oncotarget"},{"key":"1228_CR78","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1080\/15384101.2016.1138187","volume":"15","author":"D Urrego","year":"2016","unstructured":"Urrego D, Movsisyan N, Ufartes R, Pardo LA (2016) Periodic expression of Kv10.1 driven by pRb\/E2F1 contributes to G2\/M progression of cancer and non-transformed cells. Cell Cycle 15:799\u2013811. https:\/\/doi.org\/10.1080\/15384101.2016.1138187","journal-title":"Cell Cycle"},{"key":"1228_CR79","doi-asserted-by":"publisher","first-page":"2409","DOI":"10.3390\/cancers12092409","volume":"12","author":"N Movsisyan","year":"2020","unstructured":"Movsisyan N, Pardo LA (2020) Kv10.1 regulates microtubule dynamics during mitosis. Cancers (Basel) 12:2409. https:\/\/doi.org\/10.3390\/cancers12092409","journal-title":"Cancers (Basel)"},{"key":"1228_CR80","doi-asserted-by":"publisher","first-page":"3827","DOI":"10.21037\/tcr-22-2276","volume":"11","author":"S Gao","year":"2022","unstructured":"Gao S, Wang W, Ye W, Wang K (2022) The mechanism study of Eag1 potassium channel in gastric cancer. Transl Cancer Res 11:3827\u20133840. https:\/\/doi.org\/10.21037\/tcr-22-2276","journal-title":"Transl Cancer Res"},{"key":"1228_CR81","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1038\/s41388-020-01522-6","volume":"40","author":"J Chen","year":"2021","unstructured":"Chen J, Xuan Z, Song W et al (2021) EAG1 enhances hepatocellular carcinoma proliferation by modulating SKP2 and metastasis through pseudopod formation. Oncogene 40:163\u2013176. https:\/\/doi.org\/10.1038\/s41388-020-01522-6","journal-title":"Oncogene"},{"key":"1228_CR82","doi-asserted-by":"publisher","first-page":"920","DOI":"10.3390\/cancers12040920","volume":"12","author":"I Hern\u00e1ndez-Res\u00e9ndiz","year":"2020","unstructured":"Hern\u00e1ndez-Res\u00e9ndiz I, Pacheu-Grau D, S\u00e1nchez A, Pardo LA (2020) Inhibition of Kv10.1 channels sensitizes mitochondria of cancer cells to antimetabolic agents. Cancers (Basel) 12:920. https:\/\/doi.org\/10.3390\/cancers12040920","journal-title":"Cancers (Basel)"},{"key":"1228_CR83","doi-asserted-by":"publisher","first-page":"36234","DOI":"10.1074\/jbc.M801830200","volume":"283","author":"BR Downie","year":"2008","unstructured":"Downie BR, S\u00e1nchez A, Kn\u00f6tgen H et al (2008) Eag1 expression interferes with hypoxia homeostasis and induces angiogenesis in tumors. J Biol Chem 283:36234\u201336240. https:\/\/doi.org\/10.1074\/jbc.M801830200","journal-title":"J Biol Chem"},{"key":"1228_CR84","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.1038\/s42003-025-08917-9","volume":"8","author":"N Eskandari","year":"2025","unstructured":"Eskandari N, Delisi D, O\u2019Neil R et al (2025) Activation of Kv11.1 potassium channel suppresses non-small cell lung cancer growth by promoting c-Myc degradation. Commun Biol 8:1615. https:\/\/doi.org\/10.1038\/s42003-025-08917-9","journal-title":"Commun Biol"},{"key":"1228_CR85","doi-asserted-by":"publisher","first-page":"e652","DOI":"10.1038\/cddis.2013.174","volume":"4","author":"K Lansu","year":"2013","unstructured":"Lansu K, Gentile S (2013) Potassium channel activation inhibits proliferation of breast cancer cells by activating a senescence program. Cell Death Dis 4:e652. https:\/\/doi.org\/10.1038\/cddis.2013.174","journal-title":"Cell Death Dis"},{"key":"1228_CR86","doi-asserted-by":"publisher","first-page":"101148","DOI":"10.1016\/j.neo.2025.101148","volume":"63","author":"MV Saatloo","year":"2025","unstructured":"Saatloo MV, Delisi D, Eskandari N et al (2025) Kv11.1-dependent senescence activates a lethal immune response via tumor necrosis factor alpha. Neoplasia 63:101148. https:\/\/doi.org\/10.1016\/j.neo.2025.101148","journal-title":"Neoplasia"},{"key":"1228_CR87","doi-asserted-by":"publisher","first-page":"eaaf3236","DOI":"10.1126\/scisignal.aaf3236","volume":"10","author":"A Becchetti","year":"2017","unstructured":"Becchetti A, Crescioli S, Zanieri F et al (2017) The conformational state of hERG1 channels determines integrin association, downstream signaling, and cancer progression. Sci Signal 10:eaaf3236. https:\/\/doi.org\/10.1126\/scisignal.aaf3236","journal-title":"Sci Signal"},{"key":"1228_CR88","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1179\/102453311X12940641878000","volume":"16","author":"F Zheng","year":"2011","unstructured":"Zheng F, Li H, Du W, Huang S (2011) Role of hERG1 K(+) channels in leukemia cells as a positive regulator in SDF-1a-induced proliferation. Hematology 16:177\u2013184. https:\/\/doi.org\/10.1179\/102453311X12940641878000","journal-title":"Hematology"},{"key":"1228_CR89","doi-asserted-by":"publisher","first-page":"e202302135","DOI":"10.26508\/lsa.202302135","volume":"7","author":"C Duranti","year":"2024","unstructured":"Duranti C, Iorio J, Bagni G et al (2024) Integrins regulate hERG1 dynamics by girdin-dependent G\u03b1i3: Signaling and modeling in cancer cells. Life Sci Alliance 7:e202302135. https:\/\/doi.org\/10.26508\/lsa.202302135","journal-title":"Life Sci Alliance"},{"key":"1228_CR90","doi-asserted-by":"publisher","first-page":"135","DOI":"10.3390\/cancers11020135","volume":"11","author":"S Manoli","year":"2019","unstructured":"Manoli S, Coppola S, Duranti C et al (2019) The Activity of Kv 11.1 Potassium Channel Modulates F-Actin Organization During Cell Migration of Pancreatic Ductal Adenocarcinoma Cells. Cancers (Basel) 11:135. https:\/\/doi.org\/10.3390\/cancers11020135","journal-title":"Cancers (Basel)"},{"key":"1228_CR91","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1158\/0008-5472.CAN-15-1465","volume":"76","author":"D Crott\u00e8s","year":"2016","unstructured":"Crott\u00e8s D, Rapetti-Mauss R, Alcaraz-Perez F et al (2016) SIGMAR1 Regulates Membrane Electrical Activity in Response to Extracellular Matrix Stimulation to Drive Cancer Cell Invasiveness. Cancer Res 76:607\u2013618. https:\/\/doi.org\/10.1158\/0008-5472.CAN-15-1465","journal-title":"Cancer Res"},{"key":"1228_CR92","doi-asserted-by":"publisher","first-page":"10323","DOI":"10.2147\/OTT.S268055","volume":"13","author":"Z Li","year":"2020","unstructured":"Li Z, Huang L, Wei L et al (2020) KCNH3 predicts poor prognosis and promotes progression in ovarian cancer. Onco Targets Ther 13:10323\u20131033 https:\/\/doi.org\/10.2147\/OTT.S268055","journal-title":"Onco Targets Ther<br>"},{"key":"1228_CR93","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1007\/s10456-019-09696-8","volume":"23","author":"RA Deckelbaum","year":"2020","unstructured":"Deckelbaum RA, Lobov IB, Cheung E et al (2020) The potassium channel Kcne3 is a VEGFA-inducible gene selectively expressed by vascular endothelial tip cells. Angiogenesis 23:179\u2013192. https:\/\/doi.org\/10.1007\/s10456-019-09696-8","journal-title":"Angiogenesis"},{"key":"1228_CR94","doi-asserted-by":"publisher","first-page":"154234","DOI":"10.1016\/j.prp.2022.154234","volume":"241","author":"K Tian","year":"2023","unstructured":"Tian K, Tao Z, Chen Y et al (2023) KCNE4 expression is correlated with the pathological characteristics of colorectal cancer patients and associated with the radioresistance of cancer cells. Pathol Res Pract 241:154234. https:\/\/doi.org\/10.1016\/j.prp.2022.154234","journal-title":"Pathol Res Pract"},{"key":"1228_CR95","doi-asserted-by":"publisher","first-page":"622","DOI":"10.3892\/mmr.2021.12261","volume":"24","author":"S Chen","year":"2021","unstructured":"Chen S, Huang M, Hu X (2021) Interference with KCNJ2 inhibits proliferation, migration and EMT progression of apillary thyroid carcinoma cells by upregulating GNG2 expression. Mol Med Rep 24:622. https:\/\/doi.org\/10.3892\/mmr.2021.12261","journal-title":"Mol Med Rep"},{"key":"1228_CR96","doi-asserted-by":"publisher","first-page":"3041","DOI":"10.1158\/0008-5472.CAN-17-3776","volume":"78","author":"C-D Ji","year":"2018","unstructured":"Ji C-D, Wang Y-X, Xiang D-F et al (2018) Kir2.1 interaction with Stk38 promotes invasion and metastasis of human gastric cancer by enhancing MEKK2\u2013MEK1\/2\u2013ERK1\/2 signaling. Cancer Res 78:3041\u20133053. https:\/\/doi.org\/10.1158\/0008-5472.CAN-17-3776","journal-title":"Cancer Res"},{"key":"1228_CR97","doi-asserted-by":"publisher","first-page":"2210652","DOI":"10.1155\/ijog\/2210652","volume":"2025","author":"Q Zhao","year":"2025","unstructured":"Zhao Q, Wei Z, Yang G et al (2025) KCNJ2 facilitates clear cell renal cell carcinoma progression and glucose metabolism. Int J Genomics 2025:2210652. https:\/\/doi.org\/10.1155\/ijog\/2210652","journal-title":"Int J Genomics"},{"key":"1228_CR98","doi-asserted-by":"publisher","first-page":"mjaf048","DOI":"10.1093\/jmcb\/mjaf048","volume":"17","author":"Z Zhao","year":"2025","unstructured":"Zhao Z, Bai M, Wang S et al (2025) The inwardly rectifying potassium channel KCNJ12 regulates the stemness of hepatocellular carcinoma cells through the Wnt\/\u03b2-catenin pathway. J Mol Cell Biol 17:mjaf048. https:\/\/doi.org\/10.1093\/jmcb\/mjaf048","journal-title":"J Mol Cell Biol"},{"key":"1228_CR99","doi-asserted-by":"publisher","first-page":"2559","DOI":"10.1245\/s10434-019-08189-8","volume":"27","author":"S Nakamura","year":"2020","unstructured":"Nakamura S, Kanda M, Koike M et al (2020) KCNJ15 expression and malignant behavior of esophageal squamous cell carcinoma. Ann Surg Oncol 27:2559\u20132568. https:\/\/doi.org\/10.1245\/s10434-019-08189-8","journal-title":"Ann Surg Oncol"},{"key":"1228_CR100","doi-asserted-by":"publisher","first-page":"2558","DOI":"10.1038\/s41388-023-02772-w","volume":"42","author":"JA Scarth","year":"2023","unstructured":"Scarth JA, Wasson CW, Patterson MR et al (2023) Exploitation of ATP-sensitive potassium ion (KATP) channels by HPV promotes cervical cancer cell proliferation by contributing to MAPK\/AP-1 signalling. Oncogene 42:2558\u20132577. https:\/\/doi.org\/10.1038\/s41388-023-02772-w","journal-title":"Oncogene"},{"key":"1228_CR101","doi-asserted-by":"publisher","first-page":"326","DOI":"10.21053\/ceo.2024.00164","volume":"17","author":"HW Baek","year":"2024","unstructured":"Baek HW, Han E, Oh KH (2024) Exploring the role of the KCNK1 potassium channel and its inhibition using quinidine in treating head and neck squamous cell carcinoma. Clin Exp Otorhinolaryngol 17:326\u2013335. https:\/\/doi.org\/10.21053\/ceo.2024.00164","journal-title":"Clin Exp Otorhinolaryngol"},{"key":"1228_CR102","doi-asserted-by":"publisher","first-page":"e3002666","DOI":"10.1371\/journal.pbio.3002666","volume":"22","author":"X Hou","year":"2024","unstructured":"Hou X, Ouyang J, Tang L et al (2024) KCNK1 promotes proliferation and metastasis of breast cancer cells by activating lactate dehydrogenase a (LDHA) and up-regulating H3K18 lactylation. PLoS Biol 22:e3002666. https:\/\/doi.org\/10.1371\/journal.pbio.3002666","journal-title":"PLoS Biol"},{"key":"1228_CR103","doi-asserted-by":"publisher","first-page":"6077","DOI":"10.3390\/ijms20236077","volume":"20","author":"R Cikutovi\u0107-Molina","year":"2019","unstructured":"Cikutovi\u0107-Molina R, Herrada AA, Gonz\u00e1lez W et al (2019) TASK-3 gene knockdown dampens invasion and migration and promotes apoptosis in KATO III and MKN-45 human gastric adenocarcinoma cell lines. Int JMol Sci 20:6077. https:\/\/doi.org\/10.3390\/ijms20236077","journal-title":"Int J Mol Sci"},{"key":"1228_CR104","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1038\/s41420-022-01152-9","volume":"8","author":"G Lin","year":"2022","unstructured":"Lin G, Lin L, Lin H et al (2022) KCNK3 inhibits proliferation and glucose metabolism of lung adenocarcinoma via activation of AMPK-TXNIP pathway. Cell Death Discov 8:360. https:\/\/doi.org\/10.1038\/s41420-022-01152-9","journal-title":"Cell Death Discov"},{"key":"1228_CR105","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.1186\/s12885-018-5027-9","volume":"18","author":"F Wang","year":"2018","unstructured":"Wang F, Chen Q, Huang G et al (2018) BKCa participates in E2 inducing endometrial adenocarcinoma by activating MEK\/ERK pathway. BMC Cancer 18:1128. https:\/\/doi.org\/10.1186\/s12885-018-5027-9","journal-title":"BMC Cancer"},{"key":"1228_CR106","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1186\/s12885-020-07071-1","volume":"20","author":"G Sizemore","year":"2020","unstructured":"Sizemore G, McLaughlin S, Newman M et al (2020) Opening large-conductance potassium channels selectively induced cell death of triple-negative breast cancer. BMC Cancer 20:595. https:\/\/doi.org\/10.1186\/s12885-020-07071-1","journal-title":"BMC Cancer"},{"key":"1228_CR107","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/s12943-017-0613-z","volume":"16","author":"G Ma","year":"2017","unstructured":"Ma G, Liu H, Hua Q et al (2017) KCNMA1 cooperating with PTK2 is a novel tumor suppressor in gastric cancer and is associated with disease outcome. Mol Cancer 16:46. https:\/\/doi.org\/10.1186\/s12943-017-0613-z","journal-title":"Mol Cancer"},{"key":"1228_CR108","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-026-03189-6","author":"T Buchtova","year":"2026","unstructured":"Buchtova T, Bartkova J, Yamamoto T et al (2026) Dynamic calcium\u2013potassium balancing by KCNMA1 preserves the epithelial\/mesenchymal hybrid state and modulates therapy response in ovarian cancer. Cell Death Discov. https:\/\/doi.org\/10.1038\/s41420-026-03189-6","journal-title":"Cell Death Discov"},{"key":"1228_CR109","doi-asserted-by":"publisher","first-page":"6019","DOI":"10.3390\/ijms25116019","volume":"25","author":"S Ohya","year":"2024","unstructured":"Ohya S, Kito H, Kajikuri J et al (2024) Transcriptional up-regulation of FBXW7 by KCa1.1 K+ channel inhibition through the Nrf2 signaling pathway in human prostate cancer LNCaP cell spheroid model. Int J Mol Sci 25:6019. https:\/\/doi.org\/10.3390\/ijms25116019","journal-title":"Int J Mol Sci"},{"key":"1228_CR110","doi-asserted-by":"publisher","first-page":"2120","DOI":"10.1002\/jcp.31072","volume":"238","author":"A Michelucci","year":"2023","unstructured":"Michelucci A, Sforna L, Di Battista A et al (2023) Ca2+ -activated K+ channels regulate cell volume in human glioblastoma cells. J Cell Physiol 238:2120\u20132134. https:\/\/doi.org\/10.1002\/jcp.31072","journal-title":"J Cell Physiol"},{"key":"1228_CR111","doi-asserted-by":"publisher","first-page":"RP92511","DOI":"10.7554\/eLife.92511","volume":"12","author":"H Bischof","year":"2024","unstructured":"Bischof H, Maier S, Koprowski P et al (2024) mitoBKCa is functionally expressed in murine and human breast cancer cells and potentially contributes to metabolic reprogramming. Elife 12:RP92511. https:\/\/doi.org\/10.7554\/eLife.92511","journal-title":"Elife"},{"key":"1228_CR112","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1093\/carcin\/bgad070","volume":"44","author":"B Xiao","year":"2023","unstructured":"Xiao B, Xiang Q, Deng Z et al (2023) KCNN1 promotes proliferation and metastasis of breast cancer via ERLIN2-mediated stabilization and K63-dependent ubiquitination of cyclin B1. Carcinogenesis 44:809\u2013823. https:\/\/doi.org\/10.1093\/carcin\/bgad070","journal-title":"Carcinogenesis"},{"key":"1228_CR113","doi-asserted-by":"publisher","first-page":"1853","DOI":"10.1002\/1878-0261.13631","volume":"18","author":"O Romito","year":"2024","unstructured":"Romito O, Lemettre A, Chant\u00f4me A et al (2024) Plasma membrane SK2 channel activity regulates migration and chemosensitivity of high-grade serous ovarian cancer cells. Mol Oncol 18:1853\u20131865. https:\/\/doi.org\/10.1002\/1878-0261.13631","journal-title":"Mol Oncol"},{"key":"1228_CR114","doi-asserted-by":"publisher","first-page":"5107","DOI":"10.1038\/sj.onc.1210308","volume":"26","author":"ZH Wang","year":"2007","unstructured":"Wang ZH, Shen B, Yao HL et al (2007) Blockage of intermediate-conductance-Ca(2+) -activated K(+) channels inhibits progression of human endometrial cancer. Oncogene 26:5107\u20135114. https:\/\/doi.org\/10.1038\/sj.onc.1210308","journal-title":"Oncogene"},{"key":"1228_CR115","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1038\/s41401-021-00688-3","volume":"43","author":"X Mo","year":"2022","unstructured":"Mo X, Zhang C, Xu P et al (2022) KCNN4-mediated Ca2+\/MET\/AKT axis is promising for targeted therapy of pancreatic ductal adenocarcinoma. Acta Pharmacol Sin 43:735\u2013746. https:\/\/doi.org\/10.1038\/s41401-021-00688-3","journal-title":"Acta Pharmacol Sin"},{"key":"1228_CR116","doi-asserted-by":"publisher","first-page":"6958","DOI":"10.3390\/ijms23136958","volume":"23","author":"J Fan","year":"2022","unstructured":"Fan J, Tian R, Yang X et al (2022) KCNN4 Promotes the Stemness Potentials of Liver Cancer Stem Cells by Enhancing Glucose Metabolism. Int JMol Sci 23:6958. https:\/\/doi.org\/10.3390\/ijms23136958","journal-title":"Int J Mol Sci"},{"key":"1228_CR117","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1038\/s41419-022-05329-z","volume":"13","author":"D Gross","year":"2022","unstructured":"Gross D, Bischof H, Maier S et al (2022) IKCa channels control breast cancer metabolism including AMPK-driven autophagy. Cell Death Dis 13:902. https:\/\/doi.org\/10.1038\/s41419-022-05329-z","journal-title":"Cell Death Dis"},{"key":"1228_CR118","doi-asserted-by":"publisher","first-page":"116651","DOI":"10.1016\/j.biopha.2024.116651","volume":"175","author":"S Cheng","year":"2024","unstructured":"Cheng S, Jiang D, Lan X et al (2024) Voltage-gated potassium channel 1.3: A promising molecular target in multiple disease therapy. Biomed Pharmacother 175:116651. https:\/\/doi.org\/10.1016\/j.biopha.2024.116651","journal-title":"Biomed Pharmacother"},{"key":"1228_CR119","doi-asserted-by":"publisher","first-page":"102258","DOI":"10.1016\/j.ceca.2020.102258","volume":"91","author":"MJ Rosendo-Pineda","year":"2020","unstructured":"Rosendo-Pineda MJ, Moreno CM, Vaca L (2020) Role of ion channels during cell division. Cell Calcium 91:102258. https:\/\/doi.org\/10.1016\/j.ceca.2020.102258","journal-title":"Cell Calcium"},{"key":"1228_CR120","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.3390\/biom10081200","volume":"10","author":"A Wrzosek","year":"2020","unstructured":"Wrzosek A, Augustynek B, \u017bochowska M, Szewczyk A (2020) Mitochondrial Potassium Channels as Druggable Targets. Biomolecules 10:1200. https:\/\/doi.org\/10.3390\/biom10081200","journal-title":"Biomolecules"},{"key":"1228_CR121","doi-asserted-by":"publisher","first-page":"114673","DOI":"10.1016\/j.biopha.2023.114673","volume":"162","author":"C Xia","year":"2023","unstructured":"Xia C, Liu C, Ren S et al (2023) Potassium channels, tumorigenesis and targeted drugs. Biomed Pharmacother 162:114673. https:\/\/doi.org\/10.1016\/j.biopha.2023.114673","journal-title":"Biomed Pharmacother"},{"key":"1228_CR122","doi-asserted-by":"publisher","first-page":"76","DOI":"10.3892\/ijo.2021.5256","volume":"59","author":"A Shiozaki","year":"2021","unstructured":"Shiozaki A, Konishi T, Kosuga T et al (2021) Roles of voltage\u2013gated potassium channels in the maintenance of pancreatic cancer stem cells. Int J Oncol 59:76. https:\/\/doi.org\/10.3892\/ijo.2021.5256","journal-title":"Int J Oncol"},{"key":"1228_CR123","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1038\/s41392-020-0134-x","volume":"5","author":"J Fares","year":"2020","unstructured":"Fares J, Fares MY, Khachfe HH et al (2020) Molecular principles of metastasis: A hallmark of cancer revisited. Signal Transduct Target Ther 5:28. https:\/\/doi.org\/10.1038\/s41392-020-0134-x","journal-title":"Signal Transduct Target Ther"},{"key":"1228_CR124","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1186\/s13045-022-01347-8","volume":"15","author":"Y Huang","year":"2022","unstructured":"Huang Y, Hong W, Wei X (2022) The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis. J Hematol Oncol 15:129. https:\/\/doi.org\/10.1186\/s13045-022-01347-8","journal-title":"J Hematol Oncol"},{"key":"1228_CR125","doi-asserted-by":"publisher","first-page":"e1600200","DOI":"10.1126\/sciadv.1600200","volume":"2","author":"RJ DeBerardinis","year":"2016","unstructured":"DeBerardinis RJ, Chandel NS (2016) Fundamentals of cancer metabolism. Sci Adv 2:e1600200. https:\/\/doi.org\/10.1126\/sciadv.1600200","journal-title":"Sci Adv"},{"key":"1228_CR126","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1016\/j.cell.2023.01.038","volume":"186","author":"LWS Finley","year":"2023","unstructured":"Finley LWS (2023) What is cancer metabolism? Cell 186:1670\u20131688. https:\/\/doi.org\/10.1016\/j.cell.2023.01.038","journal-title":"Cell"},{"key":"1228_CR127","doi-asserted-by":"publisher","first-page":"5209","DOI":"10.3390\/ijms22105209","volume":"22","author":"SF Pedersen","year":"2021","unstructured":"Pedersen SF, Flinck M, Pardo LA (2021) The interplay between dysregulated ion transport and mitochondrial architecture as a dangerous liaison in cancer. Int J Mol Sci 22:5209. https:\/\/doi.org\/10.3390\/ijms22105209","journal-title":"Int J Mol Sci"},{"key":"1228_CR128","doi-asserted-by":"publisher","first-page":"656364","DOI":"10.3389\/fimmu.2021.656364","volume":"12","author":"K Khalaf","year":"2021","unstructured":"Khalaf K, Hana D, Chou JT-T et al (2021) Aspects of the tumor microenvironment involved in immune resistance and drug resistance. Front Immunol 12:656364. https:\/\/doi.org\/10.3389\/fimmu.2021.656364","journal-title":"Front Immunol"},{"key":"1228_CR129","doi-asserted-by":"publisher","first-page":"1626","DOI":"10.3390\/cancers16091626","volume":"16","author":"TC Dakal","year":"2024","unstructured":"Dakal TC, George N, Xu C et al (2024) Predictive and prognostic relevance of tumor-infiltrating immune cells: Tailoring personalized treatments against different cancer types. Cancers (Basel) 16:1626. https:\/\/doi.org\/10.3390\/cancers16091626","journal-title":"Cancers (Basel)"},{"key":"1228_CR130","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1002\/mco2.6","volume":"1","author":"R Shi","year":"2020","unstructured":"Shi R, Tang Y, Miao H (2020) Metabolism in tumor microenvironment: implications for cancer immunotherapy. MedComm (2020) 1:47\u201368. https:\/\/doi.org\/10.1002\/mco2.6","journal-title":"MedComm (2020)"},{"key":"1228_CR131","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1038\/nrc.2017.77","volume":"17","author":"C Corbet","year":"2017","unstructured":"Corbet C, Feron O (2017) Tumour acidosis: From the passenger to the driver\u2019s seat. Nat Rev Cancer 17:577\u2013593. https:\/\/doi.org\/10.1038\/nrc.2017.77","journal-title":"Nat Rev Cancer"},{"key":"1228_CR132","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1038\/s41416-020-01048-4","volume":"124","author":"H Raskov","year":"2021","unstructured":"Raskov H, Orhan A, Christensen JP, G\u00f6genur I (2021) Cytotoxic CD8\u2009+\u2009T cells in cancer and cancer immunotherapy. Br J Cancer 124:359\u2013367. https:\/\/doi.org\/10.1038\/s41416-020-01048-4","journal-title":"Br J Cancer"},{"key":"1228_CR133","doi-asserted-by":"publisher","first-page":"106938","DOI":"10.1016\/j.imlet.2024.106938","volume":"270","author":"J Busselaar","year":"2024","unstructured":"Busselaar J, Sijbranda M, Borst J (2024) The importance of type I interferon in orchestrating the cytotoxic T-cell response to cancer. Immunol Lett 270:106938. https:\/\/doi.org\/10.1016\/j.imlet.2024.106938","journal-title":"Immunol Lett"},{"key":"1228_CR134","doi-asserted-by":"publisher","first-page":"750542","DOI":"10.3389\/fimmu.2021.750542","volume":"12","author":"P Grover","year":"2021","unstructured":"Grover P, Goel PN, Greene MI (2021) Regulatory T cells: Regulation of identity and function. Front Immunol 12:750542. https:\/\/doi.org\/10.3389\/fimmu.2021.750542","journal-title":"Front Immunol"},{"key":"1228_CR135","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1089\/bioe.2019.0016","volume":"1","author":"ST Ong","year":"2019","unstructured":"Ong ST, Ng AS, Ng XR et al (2019) Extracellular K+ dampens T cell functions: Implications for immune suppression in the tumor microenvironment. Bioelectricity 1:169\u2013179. https:\/\/doi.org\/10.1089\/bioe.2019.0016","journal-title":"Bioelectricity"},{"key":"1228_CR136","doi-asserted-by":"publisher","first-page":"eaau0135","DOI":"10.1126\/science.aau0135","volume":"363","author":"SK Vodnala","year":"2019","unstructured":"Vodnala SK, Eil R, Kishton RJ et al (2019) T cell stemness and dysfunction in tumors are triggered by a common mechanism. Science 363:eaau0135. https:\/\/doi.org\/10.1126\/science.aau0135","journal-title":"Science"},{"key":"1228_CR137","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1111\/j.1600-065X.2009.00816.x","volume":"231","author":"MD Cahalan","year":"2009","unstructured":"Cahalan MD, Chandy KG (2009) The functional network of ion channels in T lymphocytes. Immunol Rev 231:59\u201387. https:\/\/doi.org\/10.1111\/j.1600-065X.2009.00816.x","journal-title":"Immunol Rev"},{"key":"1228_CR138","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1038\/nri3233","volume":"12","author":"S Feske","year":"2012","unstructured":"Feske S, Skolnik EY, Prakriya M (2012) Ion channels and transporters in lymphocyte function and immunity. Nat Rev Immunol 12:532\u2013547. https:\/\/doi.org\/10.1038\/nri3233","journal-title":"Nat Rev Immunol"},{"key":"1228_CR139","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1146\/annurev-immunol-032414-112212","volume":"33","author":"S Feske","year":"2015","unstructured":"Feske S, Wulff H, Skolnik EY (2015) Ion channels in innate and adaptive immunity. Annu Rev Immunol 33:291\u2013353. https:\/\/doi.org\/10.1146\/annurev-immunol-032414-112212","journal-title":"Annu Rev Immunol"},{"key":"1228_CR140","doi-asserted-by":"publisher","first-page":"1949","DOI":"10.3390\/ijms25041949","volume":"25","author":"V Jusztus","year":"2024","unstructured":"Jusztus V, Medyouni G, Bagosi A et al (2024) Activity of potassium channels in CD8\u2009+\u2009T lymphocytes: Diagnostic and prognostic biomarker in ovarian cancer? Int J Mol Sci 25:1949. https:\/\/doi.org\/10.3390\/ijms25041949","journal-title":"Int J Mol Sci"},{"key":"1228_CR141","doi-asserted-by":"publisher","first-page":"C27","DOI":"10.1152\/ajpcell.00136.2017","volume":"314","author":"MT P\u00e9rez-Garc\u00eda","year":"2018","unstructured":"P\u00e9rez-Garc\u00eda MT, Cidad P, L\u00f3pez-L\u00f3pez JR (2018) The secret life of ion channels: Kv1.3 potassium channels and proliferation. Am J Physiol Cell Physiol 314:C27\u2013C42. https:\/\/doi.org\/10.1152\/ajpcell.00136.2017","journal-title":"Am J Physiol Cell Physiol"},{"key":"1228_CR142","doi-asserted-by":"publisher","first-page":"e54267","DOI":"10.1371\/journal.pone.0054267","volume":"8","author":"L Hu","year":"2013","unstructured":"Hu L, Wang T, Gocke AR et al (2013) Blockade of Kv1.3 potassium channels inhibits differentiation and granzyme B secretion of human CD8\u2009+\u2009T effector memory lymphocytes. PLoS ONE 8:e54267. https:\/\/doi.org\/10.1371\/journal.pone.0054267","journal-title":"PLoS ONE"},{"key":"1228_CR143","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1038\/nature19364","volume":"537","author":"R Eil","year":"2016","unstructured":"Eil R, Vodnala SK, Clever D et al (2016) Ionic immune suppression within the tumour microenvironment limits T cell effector function. Nature 537:539\u2013543. https:\/\/doi.org\/10.1038\/nature19364","journal-title":"Nature"},{"key":"1228_CR144","doi-asserted-by":"publisher","first-page":"1380655","DOI":"10.3389\/fphar.2024.1380655","volume":"15","author":"M Cozzolino","year":"2024","unstructured":"Cozzolino M, Panyi G (2024) Intracellular acidity impedes KCa3.1 activation by riluzole and SKA-31. Front Pharmacol 15:1380655. https:\/\/doi.org\/10.3389\/fphar.2024.1380655","journal-title":"Front Pharmacol"},{"key":"1228_CR145","doi-asserted-by":"publisher","first-page":"eaaq1616","DOI":"10.1126\/scisignal.aaq1616","volume":"11","author":"AA Chimote","year":"2018","unstructured":"Chimote AA, Balajthy A, Arnold MJ et al (2018) A defect in KCa3.1 channel activity limits the ability of CD8\u2009+\u2009T cells from cancer patients to infiltrate an adenosine-rich microenvironment. Sci Signal 11:eaaq1616. https:\/\/doi.org\/10.1126\/scisignal.aaq1616","journal-title":"Sci Signal"},{"key":"1228_CR146","doi-asserted-by":"publisher","first-page":"14861","DOI":"10.1073\/pnas.0804236105","volume":"105","author":"I Szab\u00f3","year":"2008","unstructured":"Szab\u00f3 I, Bock J, Grassm\u00e9 H et al (2008) Mitochondrial potassium channel Kv1.3 mediates bax-induced apoptosis in lymphocytes. Proc Natl Acad Sci U S A 105:14861\u201314866. https:\/\/doi.org\/10.1073\/pnas.0804236105","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1228_CR147","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1158\/2326-6066.CIR-17-0249","volume":"6","author":"BL Horton","year":"2018","unstructured":"Horton BL, Williams JB, Cabanov A et al (2018) Intratumoral CD8\u2009+\u2009T-cell apoptosis is a major component of T-cell dysfunction and impedes anti-tumor immunity. Cancer Immunol Res 6:14\u201324. https:\/\/doi.org\/10.1158\/2326-6066.CIR-17-0249","journal-title":"Cancer Immunol Res"},{"key":"1228_CR148","doi-asserted-by":"publisher","first-page":"839986","DOI":"10.3389\/fcell.2022.839986","volume":"10","author":"Y Zou","year":"2022","unstructured":"Zou Y, Xie J, Tian W et al (2022) Integrative analysis of KCNK genes and establishment of a specific prognostic signature for breast cancer. Front Cell Dev Biol 10:839986. https:\/\/doi.org\/10.3389\/fcell.2022.839986","journal-title":"Front Cell Dev Biol"},{"key":"1228_CR149","doi-asserted-by":"publisher","first-page":"2454","DOI":"10.21037\/tau-21-332","volume":"10","author":"S Chen","year":"2021","unstructured":"Chen S, Wang C, Su X et al (2021) KCNN4 is a potential prognostic marker and critical factor affecting the immune status of the tumor microenvironment in kidney renal clear cell carcinoma. Transl Androl Urol 10:2454\u20132470. https:\/\/doi.org\/10.21037\/tau-21-332","journal-title":"Transl Androl Urol"},{"key":"1228_CR150","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1016\/j.cell.2021.01.010","volume":"184","author":"S Cheng","year":"2021","unstructured":"Cheng S, Li Z, Gao R et al (2021) A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells. Cell 184:792\u2013809e23. https:\/\/doi.org\/10.1016\/j.cell.2021.01.010","journal-title":"Cell"},{"key":"1228_CR151","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1146\/annurev-physiol-022516-034339","volume":"79","author":"PJ Murray","year":"2017","unstructured":"Murray PJ (2017) Macrophage polarization. Annu Rev Physiol 79:541\u2013566. https:\/\/doi.org\/10.1146\/annurev-physiol-022516-034339","journal-title":"Annu Rev Physiol"},{"key":"1228_CR152","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1186\/s40364-021-00327-3","volume":"9","author":"Y Qiu","year":"2021","unstructured":"Qiu Y, Chen T, Hu R et al (2021) Next frontier in tumor immunotherapy: Macrophage-mediated immune evasion. Biomark Res 9:72. https:\/\/doi.org\/10.1186\/s40364-021-00327-3","journal-title":"Biomark Res"},{"key":"1228_CR153","doi-asserted-by":"publisher","first-page":"1843","DOI":"10.1016\/j.cmet.2022.08.016","volume":"34","author":"S Chen","year":"2022","unstructured":"Chen S, Cui W, Chi Z et al (2022) Tumor-associated macrophages are shaped by intratumoral high potassium via Kir2.1. Cell Metabol 34:1843\u20131859e11. https:\/\/doi.org\/10.1016\/j.cmet.2022.08.016","journal-title":"Cell Metabol"},{"key":"1228_CR154","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1186\/1471-2407-14-330","volume":"14","author":"H Xu","year":"2014","unstructured":"Xu H, Lai W, Zhang Y et al (2014) Tumor-associated macrophage-derived IL-6 and IL-8 enhance invasive activity of LoVo cells induced by PRL-3 in a KCNN4 channel-dependent manner. BMC Cancer 14:330. https:\/\/doi.org\/10.1186\/1471-2407-14-330","journal-title":"BMC Cancer"},{"key":"1228_CR155","doi-asserted-by":"publisher","first-page":"1002487","DOI":"10.3389\/fncel.2022.1002487","volume":"16","author":"F Massenzio","year":"2022","unstructured":"Massenzio F, Cambiaghi M, Marchiotto F et al (2022) In vivo morphological alterations of TAMs during KCa3.1 inhibition-by using in vivo two-photon time-lapse technology. Front Cell Neurosci 16:1002487. https:\/\/doi.org\/10.3389\/fncel.2022.1002487","journal-title":"Front Cell Neurosci"},{"key":"1228_CR156","doi-asserted-by":"publisher","first-page":"7624","DOI":"10.3390\/ijms26157624","volume":"26","author":"M Matsui","year":"2025","unstructured":"Matsui M, Kajikuri J, Kito H et al (2025) Transcriptional repression of CCL2 by KCa3.1 K+ channel activation and LRRC8A anion channel inhibition in THP-1-differentiated M2 macrophages. Int J Mol Sci 26:7624. https:\/\/doi.org\/10.3390\/ijms26157624","journal-title":"Int J Mol Sci"},{"key":"1228_CR157","doi-asserted-by":"publisher","first-page":"8603","DOI":"10.3390\/ijms23158603","volume":"23","author":"S Ohya","year":"2022","unstructured":"Ohya S, Matsui M, Kajikuri J et al (2022) Downregulation of IL-8 and IL-10 by the activation of Ca2+-activated K+ channel KCa3.1 in THP-1-derived M2 macrophages. Int J Mol Sci 23:8603. https:\/\/doi.org\/10.3390\/ijms23158603","journal-title":"Int J Mol Sci"},{"key":"1228_CR158","doi-asserted-by":"publisher","first-page":"5394","DOI":"10.2174\/092986712803833281","volume":"19","author":"L Leanza","year":"2012","unstructured":"Leanza L, Zoratti M, Gulbins E, Szabo I (2012) Induction of apoptosis in macrophages via Kv1.3 and Kv1.5 potassium channels. Curr Med Chem 19:5394\u20135404. https:\/\/doi.org\/10.2174\/092986712803833281","journal-title":"Curr Med Chem"},{"key":"1228_CR159","doi-asserted-by":"publisher","first-page":"e70232","DOI":"10.1002\/jbt.70232","volume":"39","author":"Y Li","year":"2025","unstructured":"Li Y, Niu J, Sun Z, Liu J (2025) FTO-mediated m6A methylation of KCNAB2 inhibits tumor property of non\u2010small cell lung cancer cells and M2 macrophage polarization by inactivating the PI3K\/AKT pathway. J Biochem Mol Tox 39:e70232. https:\/\/doi.org\/10.1002\/jbt.70232","journal-title":"J Biochem Mol Tox"},{"key":"1228_CR160","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1002\/mc.23911","volume":"64","author":"S Liu","year":"2025","unstructured":"Liu S, Li Q, Niu L et al (2025) KCNE3 facilitates M1 macrophage polarization by suppressing the wnt\/\u03b2-catenin pathway, inhibiting glioma proliferation, migration, and invasion. Mol Carcinog 64:1090\u20131103. https:\/\/doi.org\/10.1002\/mc.23911","journal-title":"Mol Carcinog"},{"key":"1228_CR161","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.omtn.2020.08.029","volume":"22","author":"Y Wang","year":"2020","unstructured":"Wang Y, Wang Y, Xu C et al (2020) Identification of novel tumor-microenvironment-regulating factor that facilitates tumor immune infiltration in colon cancer. Mol Therapy Nucleic Acids 22:236\u2013250. https:\/\/doi.org\/10.1016\/j.omtn.2020.08.029","journal-title":"Mol Therapy Nucleic Acids"},{"key":"1228_CR162","doi-asserted-by":"publisher","first-page":"2476","DOI":"10.1002\/ijc.70313","volume":"158","author":"Z Xie","year":"2026","unstructured":"Xie Z, Liu J, Chen Y et al (2026) High potassium enhances the immunosuppressive function of myeloid-derived suppressor cells via Kir4.1-dependent metabolic reprogramming and promotes tumor immune escape. Int J Cancer 158:2476\u20132490. https:\/\/doi.org\/10.1002\/ijc.70313","journal-title":"Int J Cancer"},{"key":"1228_CR163","doi-asserted-by":"publisher","first-page":"1736","DOI":"10.3390\/cells13201736","volume":"13","author":"R Thylur Puttalingaiah","year":"2024","unstructured":"Thylur Puttalingaiah R, Dean MJ, Zheng L et al (2024) Excess Potassium Promotes Autophagy to Maintain the Immunosuppressive Capacity of Myeloid-Derived Suppressor Cells Independent of Arginase 1. Cells 13:1736. https:\/\/doi.org\/10.3390\/cells13201736","journal-title":"Cells"},{"key":"1228_CR164","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1093\/cvr\/cvab133","volume":"118","author":"R Immler","year":"2022","unstructured":"Immler R, Nadolni W, Bertsch A et al (2022) The voltage-gated potassium channel KV1.3 regulates neutrophil recruitment during inflammation. Cardiovasc Res 118:1289\u20131302. https:\/\/doi.org\/10.1093\/cvr\/cvab133","journal-title":"Cardiovasc Res"},{"key":"1228_CR165","doi-asserted-by":"publisher","first-page":"102750","DOI":"10.1016\/j.coi.2026.102750","volume":"100","author":"J Ku","year":"2026","unstructured":"Ku J, Anders H-J, Sperandio M, Immler R (2026) Beyond ion flux: the potassium channel KV1.3 and its regulatory function in neutrophils. Curr Opin Immunol 100:102750. https:\/\/doi.org\/10.1016\/j.coi.2026.102750","journal-title":"Curr Opin Immunol"},{"key":"1228_CR166","doi-asserted-by":"publisher","first-page":"e202503037","DOI":"10.1083\/jcb.202503037","volume":"225","author":"T Wang","year":"2026","unstructured":"Wang T, Kim DH, Ding C et al (2026) Inwardly rectifying potassium channels promote directional sensing during neutrophil chemotaxis. J Cell Biol 225:e202503037. https:\/\/doi.org\/10.1083\/jcb.202503037","journal-title":"J Cell Biol"},{"key":"1228_CR167","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.coi.2018.03.011","volume":"52","author":"C Vandier","year":"2018","unstructured":"Vandier C, Velge-Roussel F (2018) Regulation of human dendritic cell immune functions by ion channels. Curr Opin Immunol 52:27\u201331. https:\/\/doi.org\/10.1016\/j.coi.2018.03.011","journal-title":"Curr Opin Immunol"},{"key":"1228_CR168","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.trsl.2014.11.010","volume":"166","author":"Z Shao","year":"2015","unstructured":"Shao Z, Gaurav R, Agrawal DK (2015) Intermediate-conductance calcium-activated potassium channel KCa3.1 and chloride channel modulate chemokine ligand (CCL19\/CCL21)-induced migration of dendritic cells. Translational Res 166:89\u2013102. https:\/\/doi.org\/10.1016\/j.trsl.2014.11.010","journal-title":"Translational Res"},{"key":"1228_CR169","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.ceca.2016.02.008","volume":"59","author":"D Crott\u00e8s","year":"2016","unstructured":"Crott\u00e8s D, F\u00e9lix R, Meley D et al (2016) Immature human dendritic cells enhance their migration through KCa3.1 channel activation. Cell Calcium 59:198\u2013207. https:\/\/doi.org\/10.1016\/j.ceca.2016.02.008","journal-title":"Cell Calcium"},{"key":"1228_CR170","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/s41571-020-0426-7","volume":"18","author":"JA Myers","year":"2021","unstructured":"Myers JA, Miller JS (2021) Exploring the NK cell platform for cancer immunotherapy. Nat reviews Clin Oncol 18:85-100 https:\/\/doi.org\/10.1038\/s41571-020-0426-7","journal-title":"Nat reviews Clin Oncol"},{"key":"1228_CR171","doi-asserted-by":"publisher","first-page":"2602","DOI":"10.1002\/eji.201445208","volume":"45","author":"A Schulte-Mecklenbeck","year":"2015","unstructured":"Schulte-Mecklenbeck A, Bittner S, Ehling P et al (2015) The two-pore domain K2 P channel TASK2 drives human NK-cell proliferation and cytolytic function. Eur J Immunol 45:2602\u20132614. https:\/\/doi.org\/10.1002\/eji.201445208","journal-title":"Eur J Immunol"},{"key":"1228_CR172","doi-asserted-by":"publisher","first-page":"1490250","DOI":"10.3389\/fimmu.2024.1490250","volume":"15","author":"N Samper","year":"2024","unstructured":"Samper N, Hardardottir L, Depierreux DM et al (2024) Kir6.1, a component of an ATP-sensitive potassium channel, regulates natural killer cell development. Front Immunol 15:1490250. https:\/\/doi.org\/10.3389\/fimmu.2024.1490250","journal-title":"Front Immunol"},{"key":"1228_CR173","doi-asserted-by":"publisher","first-page":"742862","DOI":"10.3389\/fphar.2021.742862","volume":"12","author":"VS Gawali","year":"2021","unstructured":"Gawali VS, Chimote AA, Newton HS et al (2021) Immune checkpoint inhibitors regulate K+ channel activity in cytotoxic T lymphocytes of head and neck cancer patients. Front Pharmacol 12:742862. https:\/\/doi.org\/10.3389\/fphar.2021.742862","journal-title":"Front Pharmacol"},{"key":"1228_CR174","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24032049","volume":"24","author":"G Alasiri","year":"2023","unstructured":"Alasiri G (2023) Comprehensive analysis of KCNJ14 potassium channel as a biomarker for cancer progression and development. Int J Mol Sci 24:2049. https:\/\/doi.org\/10.3390\/ijms24032049","journal-title":"Int J Mol Sci"},{"key":"1228_CR175","doi-asserted-by":"publisher","first-page":"3438","DOI":"10.3390\/cells11213438","volume":"11","author":"Y Lyu","year":"2022","unstructured":"Lyu Y, Wang Q, Liang J et al (2022) The ion channel gene KCNAB2 is associated with poor prognosis and loss of immune infiltration in lung adenocarcinoma. Cells 11:3438. https:\/\/doi.org\/10.3390\/cells11213438","journal-title":"Cells"},{"key":"1228_CR176","doi-asserted-by":"publisher","first-page":"13208","DOI":"10.1038\/s41598-022-15926-9","volume":"12","author":"R Mano","year":"2022","unstructured":"Mano R, Tanaka T, Hashiguchi S et al (2022) Induction of potassium channel regulator KCNE4 in a submandibular lymph node metastasis model. Sci Rep 12:13208. https:\/\/doi.org\/10.1038\/s41598-022-15926-9","journal-title":"Sci Rep"},{"key":"1228_CR177","doi-asserted-by":"publisher","first-page":"2678","DOI":"10.3748\/wjg.v22.i9.2678","volume":"22","author":"MFB Nielsen","year":"2016","unstructured":"Nielsen MFB, Mortensen MB, Detlefsen S (2016) Key players in pancreatic cancer-stroma interaction: Cancer-associated fibroblasts, endothelial and inflammatory cells. World J Gastoroenterol 22:2678\u20132700. https:\/\/doi.org\/10.3748\/wjg.v22.i9.2678","journal-title":"World J. Gastroenterol"},{"key":"1228_CR178","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1007\/s00424-024-03021-z","volume":"477","author":"M Rugi","year":"2025","unstructured":"Rugi M, Hofschr\u00f6er V, Peth\u0151 Z et al (2025) K2P2.1 channels modulate the pH- and mechanosensitivity of pancreatic stellate cells. Pflugers Arch 477:147\u2013157. https:\/\/doi.org\/10.1007\/s00424-024-03021-z","journal-title":"Pflugers Arch"},{"key":"1228_CR179","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1186\/s13046-024-03081-0","volume":"43","author":"V Doldi","year":"2024","unstructured":"Doldi V, Tortoreto M, Colecchia M et al (2024) Repositioning of antiarrhythmics for prostate cancer treatment: A novel strategy to reprogram cancer-associated fibroblasts towards a tumor-suppressive phenotype. J Exp Clin Cancer Res 43:161. https:\/\/doi.org\/10.1186\/s13046-024-03081-0","journal-title":"J Exp Clin Cancer Res"},{"key":"1228_CR180","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1136\/gutjnl-2021-326610","volume":"72","author":"R Rapetti-Mauss","year":"2023","unstructured":"Rapetti-Mauss R, Nigri J, Berenguier C et al (2023) SK2 channels set a signalling hub bolstering CAF-triggered tumourigenic processes in pancreatic cancer. Gut 72:722\u2013735. https:\/\/doi.org\/10.1136\/gutjnl-2021-326610","journal-title":"Gut"},{"key":"1228_CR181","doi-asserted-by":"publisher","first-page":"24653","DOI":"10.18632\/oncotarget.19065","volume":"9","author":"M Badaoui","year":"2017","unstructured":"Badaoui M, Mimsy-Julienne C, Saby C et al (2017) Collagen type 1 promotes survival of human breast cancer cells by overexpressing Kv10.1 potassium and Orai1 calcium channels through DDR1-dependent pathway. Oncotarget 9:24653\u201324671. https:\/\/doi.org\/10.18632\/oncotarget.19065","journal-title":"Oncotarget"},{"key":"1228_CR182","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1038\/s41598-018-37602-7","volume":"9","author":"M Peretti","year":"2019","unstructured":"Peretti M, Badaoui M, Girault A et al (2019) Original association of ion transporters mediates the ECM-induced breast cancer cell survival: Kv10.1-Orai1-SPCA2 partnership. Sci Rep 9:1175. https:\/\/doi.org\/10.1038\/s41598-018-37602-7","journal-title":"Sci Rep"},{"key":"1228_CR183","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1186\/s12943-019-1089-9","volume":"18","author":"X Jing","year":"2019","unstructured":"Jing X, Yang F, Shao C et al (2019) Role of hypoxia in cancer therapy by regulating the tumor microenvironment. Mol Cancer 18:157. https:\/\/doi.org\/10.1186\/s12943-019-1089-9","journal-title":"Mol Cancer"},{"key":"1228_CR184","doi-asserted-by":"publisher","first-page":"e0215905","DOI":"10.1371\/journal.pone.0215905","volume":"14","author":"DR Vaddi","year":"2019","unstructured":"Vaddi DR, Piao L, Khan SA et al (2019) Hypoxia induced hERG trafficking defect linked to cell cycle arrest in SH-SY5Y cells. PLoS ONE 14:e0215905. https:\/\/doi.org\/10.1371\/journal.pone.0215905","journal-title":"PLoS ONE"},{"key":"1228_CR185","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.3390\/ijms19041061","volume":"19","author":"MS Song","year":"2018","unstructured":"Song MS, Park SM, Park JS et al (2018) Kv3.1 and Kv3.4, Are Involved in Cancer Cell Migration and Invasion. Int J Mol Sci 19:1061. https:\/\/doi.org\/10.3390\/ijms19041061","journal-title":"Int J Mol Sci"},{"key":"1228_CR186","doi-asserted-by":"publisher","first-page":"1742","DOI":"10.3390\/biom13121742","volume":"13","author":"A Michelucci","year":"2023","unstructured":"Michelucci A, Sforna L, Franciolini F, Catacuzzeno L (2023) Hypoxia, ion channels and glioblastoma malignancy. Biomolecules 13:1742. https:\/\/doi.org\/10.3390\/biom13121742","journal-title":"Biomolecules"},{"key":"1228_CR187","doi-asserted-by":"publisher","first-page":"6866","DOI":"10.1002\/jcp.26448","volume":"233","author":"P Rosa","year":"2018","unstructured":"Rosa P, Catacuzzeno L, Sforna L et al (2018) BK channels blockage inhibits hypoxia-induced migration and chemoresistance to cisplatin in human glioblastoma cells. J Cell Physiol 233:6866\u20136877. https:\/\/doi.org\/10.1002\/jcp.26448","journal-title":"J Cell Physiol"},{"key":"1228_CR188","doi-asserted-by":"publisher","first-page":"9685","DOI":"10.1111\/jcmm.16918","volume":"25","author":"Y He","year":"2021","unstructured":"He Y, Lin Y, He F et al (2021) Role for calcium-activated potassium channels (BK) in migration control of human hepatocellular carcinoma cells. J Cell Mol Med 25:9685\u20139696. https:\/\/doi.org\/10.1111\/jcmm.16918","journal-title":"J Cell Mol Med"},{"key":"1228_CR189","doi-asserted-by":"publisher","first-page":"4786","DOI":"10.3390\/ijms21134786","volume":"21","author":"F Bery","year":"2020","unstructured":"Bery F, Figiel S, Kouba S et al (2020) Hypoxia promotes prostate cancer aggressiveness by upregulating EMT-activator Zeb1 and SK3 channel expression. Int J Mol Sci 21:4786. https:\/\/doi.org\/10.3390\/ijms21134786","journal-title":"Int J Mol Sci"},{"key":"1228_CR190","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/s12964-023-01064-w","volume":"21","author":"M Shen","year":"2023","unstructured":"Shen M, Pan R, Lei S et al (2023) KCNJ2\/HIF1\u03b1 positive-feedback loop promotes the metastasis of osteosarcoma. Cell Commun Signal 21:46. https:\/\/doi.org\/10.1186\/s12964-023-01064-w","journal-title":"Cell Commun Signal"},{"key":"1228_CR191","doi-asserted-by":"publisher","first-page":"27","DOI":"10.3390\/cells11010027","volume":"11","author":"A F\u00f6rch","year":"2021","unstructured":"F\u00f6rch A, Wallner S, Zeman F et al (2021) Expression of proton-sensitive GPR31, GPR151, TASK1 and TASK3 in common skin tumors. Cells 11:27. https:\/\/doi.org\/10.3390\/cells11010027","journal-title":"Cells"},{"key":"1228_CR192","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1038\/s41419-019-1429-0","volume":"10","author":"E-K Breuer","year":"2019","unstructured":"Breuer E-K, Fukushiro-Lopes D, Dalheim A et al (2019) Potassium channel activity controls breast cancer metastasis by affecting \u03b2-catenin signaling. Cell Death Dis 10:180. https:\/\/doi.org\/10.1038\/s41419-019-1429-0","journal-title":"Cell Death Dis"},{"key":"1228_CR193","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1007\/s13402-017-0328-6","volume":"40","author":"A Fortunato","year":"2017","unstructured":"Fortunato A (2017) The role of hERG1 ion channels in epithelial-mesenchymal transition and the capacity of riluzole to reduce cisplatin resistance in colorectal cancer cells. Cell Oncol 40:367\u2013378. https:\/\/doi.org\/10.1007\/s13402-017-0328-6","journal-title":"Cell Oncol"},{"key":"1228_CR194","doi-asserted-by":"publisher","first-page":"2565","DOI":"10.1007\/s13277-015-4081-z","volume":"37","author":"P Samuel","year":"2016","unstructured":"Samuel P, Pink RC, Caley DP et al (2016) Over-expression of miR-31 or loss of KCNMA1 leads to increased cisplatin resistance in ovarian cancer cells. Tumour Biol 37:2565\u20132573. https:\/\/doi.org\/10.1007\/s13277-015-4081-z","journal-title":"Tumour Biol"},{"key":"1228_CR195","doi-asserted-by":"publisher","first-page":"4159","DOI":"10.1073\/pnas.1702913114","volume":"114","author":"R Rapetti-Mauss","year":"2017","unstructured":"Rapetti-Mauss R, Bustos V, Thomas W et al (2017) Bidirectional KCNQ1:\u03b2-catenin interaction drives colorectal cancer cell differentiation. Proc Natl Acad Sci USA 114:4159\u20134164. https:\/\/doi.org\/10.1073\/pnas.1702913114","journal-title":"Proc Natl Acad Sci USA"},{"key":"1228_CR196","doi-asserted-by":"publisher","first-page":"166","DOI":"10.3390\/toxins17040166","volume":"17","author":"N Mata de Los Rios","year":"2025","unstructured":"Mata de Los Rios N, Gastelum-Arellanez A, Clement H et al (2025) Ion-channel-targeting scorpion recombinant toxin as novel therapeutic agent for breast cancer. Toxins (Basel) 17:166. https:\/\/doi.org\/10.3390\/toxins17040166","journal-title":"Toxins (Basel)"},{"key":"1228_CR197","doi-asserted-by":"publisher","first-page":"e70072","DOI":"10.1002\/cnr2.70072","volume":"7","author":"EM C\u00fcce-Aydo\u011fmu\u015f","year":"2024","unstructured":"C\u00fcce-Aydo\u011fmu\u015f EM, \u0130nhan-Garip GA (2024) Investigation of the effects of blocking potassium channels with 4-aminopyridine on paclitaxel activity in breast cancer cell lines. Cancer Rep (Hoboken) 7:e70072. https:\/\/doi.org\/10.1002\/cnr2.70072","journal-title":"Cancer Rep (Hoboken)"},{"key":"1228_CR198","doi-asserted-by":"publisher","first-page":"7768","DOI":"10.3390\/ijms26167768","volume":"26","author":"EM C\u00fcce-Aydo\u011fmu\u015f","year":"2025","unstructured":"C\u00fcce-Aydo\u011fmu\u015f EM, \u0130yiol P, \u0130nhan-Garip GA (2025) Targeting voltage-gated potassium channels in breast cancer: Mechanistic insights into 4-aminopyridine-induced cell death. Int J Mol Sci 26:7768. https:\/\/doi.org\/10.3390\/ijms26167768","journal-title":"Int J Mol Sci"},{"key":"1228_CR199","doi-asserted-by":"publisher","first-page":"2618","DOI":"10.3390\/cancers14112618","volume":"14","author":"W Li","year":"2022","unstructured":"Li W, Wilson GC, Bachmann M et al (2022) Inhibition of a mitochondrial potassium channel in combination with gemcitabine and abraxane drastically reduces pancreatic ductal adenocarcinoma in an immunocompetent orthotopic murine model. Cancers 14:2618. https:\/\/doi.org\/10.3390\/cancers14112618","journal-title":"Cancers"},{"key":"1228_CR200","doi-asserted-by":"publisher","first-page":"2595","DOI":"10.3390\/cancers14112595","volume":"14","author":"\u0160 Gubi\u010d","year":"2022","unstructured":"Gubi\u010d \u0160, Hendrickx L, Shi X et al (2022) Design of new potent and selective thiophene-based KV1.3 inhibitors and their potential for anticancer activity. Cancers 14:2595. https:\/\/doi.org\/10.3390\/cancers14112595","journal-title":"Cancers"},{"key":"1228_CR201","doi-asserted-by":"publisher","first-page":"3227","DOI":"10.3390\/molecules27103227","volume":"27","author":"A Teisseyre","year":"2022","unstructured":"Teisseyre A, Chmielarz M, Uryga A et al (2022) Co-application of statin and flavonoids as an effective strategy to reduce the activity of voltage-gated potassium channels Kv1.3 and induce apoptosis in human leukemic T cell line jurkat. Molecules 27:3227. https:\/\/doi.org\/10.3390\/molecules27103227","journal-title":"Molecules"},{"key":"1228_CR202","doi-asserted-by":"publisher","first-page":"2490269","DOI":"10.1080\/10717544.2025.2490269","volume":"32","author":"F Ye","year":"2025","unstructured":"Ye F, Li Q, Huang L, Liao N (2025) Reliable high-PAP-1-loaded polymeric micelles for cancer therapy: preparation, characterization, and evaluation of anti-tumor efficacy. Drug Delivery 32:2490269. https:\/\/doi.org\/10.1080\/10717544.2025.2490269","journal-title":"Drug Delivery"},{"key":"1228_CR203","doi-asserted-by":"publisher","first-page":"e0309438","DOI":"10.1371\/journal.pone.0309438","volume":"19","author":"KW Benn","year":"2024","unstructured":"Benn KW, Yuan PH, Chong HK et al (2024) hERG channel agonist NS1643 strongly inhibits invasive astrocytoma cell line SMA-560. PLoS ONE 19:e0309438. https:\/\/doi.org\/10.1371\/journal.pone.0309438","journal-title":"PLoS ONE"},{"key":"1228_CR204","doi-asserted-by":"publisher","first-page":"38947","DOI":"10.1021\/acsami.5c08042","volume":"17","author":"D Delisi","year":"2025","unstructured":"Delisi D, D\u2019Amora U, Scarpa E et al (2025) A smart injectable hydrogel packaged with an ion channel activator molecule as a targeted delivery system for the treatment of cancer. ACS Appl Mater Interfaces 17:38947\u201338959. https:\/\/doi.org\/10.1021\/acsami.5c08042","journal-title":"ACS Appl Mater Interfaces"},{"key":"1228_CR205","doi-asserted-by":"publisher","first-page":"1584","DOI":"10.1158\/1535-7163.MCT-24-0646","volume":"24","author":"C Duranti","year":"2025","unstructured":"Duranti C, Iorio J, Capitani C et al (2025) Antineoplastic activity of a novel trispecific single-chain antibody targeting the hERG1\/\u03b21 integrin complex and TRAIL receptors. Mol Cancer Ther 24:1584\u20131599. https:\/\/doi.org\/10.1158\/1535-7163.MCT-24-0646","journal-title":"Mol Cancer Ther"},{"key":"1228_CR206","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1038\/s41420-025-02321-2","volume":"11","author":"C Duranti","year":"2025","unstructured":"Duranti C, Iorio J, Manganelli V et al (2025) Targeting the hERG1\/\u03b21 integrin complex in lipid rafts potentiates statins anti-cancer activity in pancreatic cancer. Cell Death Discov 11:39. https:\/\/doi.org\/10.1038\/s41420-025-02321-2","journal-title":"Cell Death Discov"},{"key":"1228_CR207","doi-asserted-by":"publisher","first-page":"2013","DOI":"10.3390\/cancers15072013","volume":"15","author":"T Lottini","year":"2023","unstructured":"Lottini T, Duranti C, Iorio J et al (2023) Combination therapy with a bispecific antibody targeting the hERG1\/\u03b21 integrin complex and gemcitabine in pancreatic ductal adenocarcinoma. Cancers 15:2013. https:\/\/doi.org\/10.3390\/cancers15072013","journal-title":"Cancers"},{"key":"1228_CR208","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.ejphar.2019.05.017","volume":"855","author":"B Vald\u00e9s-Abad\u00eda","year":"2019","unstructured":"Vald\u00e9s-Abad\u00eda B, Mor\u00e1n-Zendejas R, Rangel-Flores JM, Rodr\u00edguez-Menchaca AA (2019) Chloroquine inhibits tumor-related Kv10.1 channel and decreases migration of MDA-MB-231 breast cancer cells in vitro. Eur J Pharmacol 855:262\u2013266. https:\/\/doi.org\/10.1016\/j.ejphar.2019.05.017","journal-title":"Eur J Pharmacol"},{"key":"1228_CR209","doi-asserted-by":"publisher","first-page":"176240","DOI":"10.1016\/j.ejphar.2023.176240","volume":"962","author":"B Ma","year":"2024","unstructured":"Ma B, Shi S, Ren S et al (2024) Corydaline binds to a druggable pocket of hEAG1 channel and inhibits hepatic carcinoma cell viability. Eur J Pharmacol 962:176240. https:\/\/doi.org\/10.1016\/j.ejphar.2023.176240","journal-title":"Eur J Pharmacol"},{"key":"1228_CR210","doi-asserted-by":"publisher","first-page":"3055","DOI":"10.3390\/ijms24033055","volume":"24","author":"L D\u00edaz","year":"2023","unstructured":"D\u00edaz L, Bernadez-Vallejo SV, Vargas-Castro R et al (2023) The phytochemical \u03b1-mangostin inhibits cervical cancer cell proliferation and tumor growth by downregulating E6\/E7-HPV oncogenes and KCNH1 gene expression. IJMS 24:3055. https:\/\/doi.org\/10.3390\/ijms24033055","journal-title":"IJMS"},{"key":"1228_CR211","doi-asserted-by":"publisher","first-page":"7161","DOI":"10.1002\/jcp.27470","volume":"234","author":"X Wang","year":"2019","unstructured":"Wang X, Chen Y, Li J et al (2019) Tetrandrine, a novel inhibitor of ether-\u00e0-go-go-1 (Eag1), targeted to cervical cancer development. J Cell Physiol 234:7161\u20137173. https:\/\/doi.org\/10.1002\/jcp.27470","journal-title":"J Cell Physiol"},{"key":"1228_CR212","doi-asserted-by":"publisher","DOI":"10.1038\/s41417-026-01029-4","author":"J Berghausen","year":"2026","unstructured":"Berghausen J, Thomas CAD, Wang Z-J et al (2026) Amitriptyline inhibits EAG1 channels by binding to their PAS domains and exerts EAG1-dependent anti-tumorigenic effects. Cancer Gene Ther. https:\/\/doi.org\/10.1038\/s41417-026-01029-4","journal-title":"Cancer Gene Ther"},{"key":"1228_CR213","doi-asserted-by":"publisher","first-page":"686","DOI":"10.3389\/fphar.2020.00686","volume":"11","author":"F Hartung","year":"2020","unstructured":"Hartung F, Kr\u00fcwel T, Shi X et al (2020) A novel anti-Kv10.1 nanobody fused to single-chain TRAIL enhances apoptosis induction in cancer cells. Front Pharmacol 11:686. https:\/\/doi.org\/10.3389\/fphar.2020.00686","journal-title":"Front Pharmacol"},{"key":"1228_CR214","doi-asserted-by":"publisher","first-page":"1963","DOI":"10.3390\/pharmaceutics14091963","volume":"14","author":"\u0160 Gubi\u010d","year":"2022","unstructured":"Gubi\u010d \u0160, Toplak \u017d, Shi X et al (2022) New diarylamine KV10.1 inhibitors and their anticancer potential. Pharmaceutics 14:1963. https:\/\/doi.org\/10.3390\/pharmaceutics14091963","journal-title":"Pharmaceutics"},{"key":"1228_CR215","doi-asserted-by":"publisher","first-page":"114982","DOI":"10.1016\/j.biopha.2023.114982","volume":"164","author":"MR Bakhsh","year":"2023","unstructured":"Bakhsh MR, Rouhi L, Ghaedi K et al (2023) Therapeutic effects of guanidine hydrochloride on breast cancer through targeting KCNG1 gene. Biomed Pharmacother 164:114982. https:\/\/doi.org\/10.1016\/j.biopha.2023.114982","journal-title":"Biomed Pharmacother"},{"key":"1228_CR216","doi-asserted-by":"publisher","first-page":"577","DOI":"10.3389\/fphar.2020.00577","volume":"11","author":"D Fukushiro-Lopes","year":"2020","unstructured":"Fukushiro-Lopes D, Hegel AD, Russo A et al (2020) Repurposing Kir6\/SUR2 channel activator minoxidil to arrests growth of gynecologic cancers. Front Pharmacol 11:577. https:\/\/doi.org\/10.3389\/fphar.2020.00577","journal-title":"Front Pharmacol"},{"key":"1228_CR217","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s40360-021-00472-3","volume":"22","author":"T-Y Hung","year":"2021","unstructured":"Hung T-Y, Huang H-YI, Wu S-N, Huang C-W (2021) Depressive effectiveness of vigabatrin (\u03b3-vinyl-GABA), an antiepileptic drug, in intermediate-conductance calcium-activated potassium channels in human glioma cells. BMC Pharmacol Toxicol 22:6. https:\/\/doi.org\/10.1186\/s40360-021-00472-3","journal-title":"BMC Pharmacol Toxicol"},{"key":"1228_CR218","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.1159\/000430404","volume":"37","author":"M-H Huang","year":"2015","unstructured":"Huang M-H, Huang Y-M, Wu S-N (2015) The inhibition by oxaliplatin, a platinum-based anti-neoplastic agent, of the activity of intermediate-conductance Ca2+-activated K+ channels in human glioma cells. Cell Physiol Biochem 37:1390\u20131406. https:\/\/doi.org\/10.1159\/000430404","journal-title":"Cell Physiol Biochem"},{"key":"1228_CR219","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1124\/mol.114.094920","volume":"87","author":"L Gasparoli","year":"2015","unstructured":"Gasparoli L, D\u2019Amico M, Masselli M et al (2015) New pyrimido-indole compound CD-160130 preferentially inhibits the KV11.1B isoform and produces antileukemic effects without cardiotoxicity. Mol Pharmacol 87:183\u2013196. https:\/\/doi.org\/10.1124\/mol.114.094920","journal-title":"Mol Pharmacol"},{"key":"1228_CR220","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1039\/d5nh00050e","volume":"10","author":"S-Y Tong","year":"2025","unstructured":"Tong S-Y, Huo C-M, Zuo Y-C et al (2025) Reversing cancer immunosuppression via K+ capture and repolarization of tumor-associated macrophages. Nanoscale Horiz 10:1107\u20131119. https:\/\/doi.org\/10.1039\/d5nh00050e","journal-title":"Nanoscale Horiz"},{"key":"1228_CR221","doi-asserted-by":"publisher","first-page":"1903","DOI":"10.1038\/s41565-024-01758-3","volume":"19","author":"M Tan","year":"2024","unstructured":"Tan M, Cao G, Wang R et al (2024) Metal-ion-chelating phenylalanine nanostructures reverse immune dysfunction and sensitize breast tumour to immune checkpoint blockade. Nat Nanotechnol 19:1903\u20131913. https:\/\/doi.org\/10.1038\/s41565-024-01758-3","journal-title":"Nat Nanotechnol"},{"key":"1228_CR222","doi-asserted-by":"publisher","first-page":"e000844","DOI":"10.1136\/jitc-2020-000844","volume":"8","author":"HS Newton","year":"2020","unstructured":"Newton HS, Gawali VS, Chimote AA et al (2020) PD1 blockade enhances K+ channel activity, Ca2\u2009+\u2009signaling, and migratory ability in cytotoxic T lymphocytes of patients with head and neck cancer. J Immunother Cancer 8:e000844. https:\/\/doi.org\/10.1136\/jitc-2020-000844","journal-title":"J Immunother Cancer"},{"key":"1228_CR223","doi-asserted-by":"publisher","first-page":"3750","DOI":"10.3390\/cancers16223750","volume":"16","author":"G Medyouni","year":"2024","unstructured":"Medyouni G, V\u00f6r\u00f6s O, Jusztus V et al (2024) Inhibition of K+ channels affects the target cell killing potential of CAR T cells. Cancers (Basel) 16:3750. https:\/\/doi.org\/10.3390\/cancers16223750","journal-title":"Cancers (Basel)"},{"key":"1228_CR224","doi-asserted-by":"publisher","first-page":"vkaf084","DOI":"10.1093\/jimmun\/vkaf084","volume":"214","author":"V Jusztus","year":"2025","unstructured":"Jusztus V, Sz\u00f6\u0151r \u00c1, Hajdu P (2025) Role of CAR-T cell K+ channels in tumor infiltration and elimination. J Immunol 214:vkaf084. https:\/\/doi.org\/10.1093\/jimmun\/vkaf084","journal-title":"J Immunol"},{"key":"1228_CR225","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.1002\/ijc.35076","volume":"155","author":"G Deshar","year":"2024","unstructured":"Deshar G, Christensen NM, Novak I (2024) Pantoprazole and riluzole target H+ \/K+ - ATPases\u2009 and pH \u2010sensitive K+ channels in pancreatic cancer cells. Intl J Cancer 155:1641\u20131654 https:\/\/doi.org\/10.1002\/ijc.35076","journal-title":"Intl J Cancer"},{"key":"1228_CR226","doi-asserted-by":"publisher","first-page":"e2594","DOI":"10.1038\/cddis.2017.6","volume":"8","author":"D Bauer","year":"2017","unstructured":"Bauer D, Werth F, Nguyen HA et al (2017) Critical role of reactive oxygen species (ROS) for synergistic enhancement of apoptosis by vemurafenib and the potassium channel inhibitor TRAM-34 in melanoma cells. Cell Death Dis 8:e2594. https:\/\/doi.org\/10.1038\/cddis.2017.6","journal-title":"Cell Death Dis"},{"key":"1228_CR227","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1002\/emmm.201200235","volume":"4","author":"L Leanza","year":"2012","unstructured":"Leanza L, Henry B, Sassi N et al (2012) Inhibitors of mitochondrial Kv1.3 channels induce bax\/bak-independent death of cancer cells. EMBO Mol Med 4:577. https:\/\/doi.org\/10.1002\/emmm.201200235","journal-title":"EMBO Mol Med"},{"key":"1228_CR228","doi-asserted-by":"publisher","first-page":"38276","DOI":"10.18632\/oncotarget.11299","volume":"8","author":"A Zaccagnino","year":"2016","unstructured":"Zaccagnino A, Manag\u00f2 A, Leanza L et al (2016) Tumor-reducing effect of the clinically used drug clofazimine in a SCID mouse model of pancreatic ductal adenocarcinoma. Oncotarget 8:38276\u201338293. https:\/\/doi.org\/10.18632\/oncotarget.11299","journal-title":"Oncotarget"},{"key":"1228_CR229","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/s13046-022-02249-w","volume":"41","author":"F Severin","year":"2022","unstructured":"Severin F, Urbani A, Varanita T et al (2022) Pharmacological modulation of Kv1.3 potassium channel selectively triggers pathological B lymphocyte apoptosis in vivo in a genetic CLL model. J Exp Clin Cancer Res 41:64. https:\/\/doi.org\/10.1186\/s13046-022-02249-w","journal-title":"J Exp Clin Cancer Res"},{"key":"1228_CR230","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.1177\/1933719115590665","volume":"22","author":"C Hui","year":"2015","unstructured":"Hui C, Lan Z, Yue-li L et al (2015) Knockdown of Eag1 expression by RNA interference increases chemosensitivity to cisplatin in ovarian cancer cells. Reprod Sci 22:1618\u20131626. https:\/\/doi.org\/10.1177\/1933719115590665","journal-title":"Reprod Sci"},{"key":"1228_CR231","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1038\/bjc.2017.392","volume":"118","author":"S Pillozzi","year":"2018","unstructured":"Pillozzi S, D\u2019Amico M, Bartoli G et al (2018) The combined activation of KCa3.1 and inhibition of Kv11.1\/hERG1 currents contribute to overcome cisplatin resistance in colorectal cancer cells. Br J Cancer 118:200\u2013212. https:\/\/doi.org\/10.1038\/bjc.2017.392","journal-title":"Br J Cancer"},{"key":"1228_CR232","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/s10735-023-10173-2","volume":"55","author":"F Chen","year":"2024","unstructured":"Chen F, Jiang J, Liu D et al (2024) The lncRNA lnc-TSI antagonizes sorafenib resistance in hepatocellular carcinoma via downregulating miR-4726-5p expression and upregulating KCNMA1 expression. J Mol Histol 55:83\u201396. https:\/\/doi.org\/10.1007\/s10735-023-10173-2","journal-title":"J Mol Histol"},{"key":"1228_CR233","doi-asserted-by":"publisher","first-page":"3769","DOI":"10.1111\/cas.15046","volume":"112","author":"S Ohya","year":"2021","unstructured":"Ohya S, Kajikuri J, Endo K et al (2021) Ca2+-activated K+ channel KCa1.1 as a therapeutic target to overcome chemoresistance in three\u2010dimensional sarcoma spheroid models. Cancer Sci 112:3769\u20133783. https:\/\/doi.org\/10.1111\/cas.15046","journal-title":"Cancer Sci"},{"key":"1228_CR234","doi-asserted-by":"publisher","first-page":"13553","DOI":"10.3390\/ijms222413553","volume":"22","author":"S Ohya","year":"2021","unstructured":"Ohya S, Kajikuri J, Endo K et al (2021) KCa1.1 K+ channel inhibition overcomes resistance to antiandrogens and doxorubicin in a human prostate cancer LNCaP spheroid model. IJMS 22:13553. https:\/\/doi.org\/10.3390\/ijms222413553","journal-title":"IJMS"},{"key":"1228_CR235","doi-asserted-by":"publisher","first-page":"15672","DOI":"10.3390\/ijms242115672","volume":"24","author":"S Ohya","year":"2023","unstructured":"Ohya S, Kajikuri J, Kito H, Matsui M (2023) Down-regulation of CYP3A4 by the KCa1.1 inhibition is responsible for overcoming resistance to doxorubicin in cancer spheroid models. Int J Mol Sci 24:15672. https:\/\/doi.org\/10.3390\/ijms242115672","journal-title":"Int J Mol Sci"},{"key":"1228_CR236","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1007\/s10142-023-01035-x","volume":"23","author":"K Huang","year":"2023","unstructured":"Huang K, Chen X, Geng Z et al (2023) LncRNA SLC25A21-AS1 increases the chemosensitivity and inhibits the progression of ovarian cancer by upregulating the expression of KCNK4. Funct Integr Genomics 23:110. https:\/\/doi.org\/10.1007\/s10142-023-01035-x","journal-title":"Funct Integr Genomics"},{"key":"1228_CR237","doi-asserted-by":"publisher","first-page":"18330","DOI":"10.1038\/s41598-021-97406-0","volume":"11","author":"F Glaser","year":"2021","unstructured":"Glaser F, Hundehege P, Bulk E et al (2021) KCa channel blockers increase effectiveness of the EGF receptor TK inhibitor erlotinib in non-small cell lung cancer cells (A549). Sci Rep 11:18330. https:\/\/doi.org\/10.1038\/s41598-021-97406-0","journal-title":"Sci Rep"},{"key":"1228_CR238","doi-asserted-by":"publisher","first-page":"e2302012","DOI":"10.1002\/adhm.202302012","volume":"13","author":"P Ma","year":"2024","unstructured":"Ma P, Luo Z, Li Z et al (2024) Mitochondrial artificial K+ channel construction using MPTPP@5F8 nanoparticles for overcoming cancer drug resistance via disrupting cellular ion homeostasis. Adv Healthc Mater 13:e2302012. https:\/\/doi.org\/10.1002\/adhm.202302012","journal-title":"Adv Healthc Mater"},{"key":"1228_CR239","doi-asserted-by":"publisher","first-page":"e2312352","DOI":"10.1002\/adma.202312352","volume":"36","author":"C Li","year":"2024","unstructured":"Li C, Wu Y, Zhu Y et al (2024) Molecular Motor-Driven Light-Controlled Logic-Gated K+ Channel for Cancer Cell Apoptosis. Adv Mater 36:e2312352. https:\/\/doi.org\/10.1002\/adma.202312352","journal-title":"Adv Mater"},{"key":"1228_CR240","doi-asserted-by":"publisher","first-page":"3282","DOI":"10.7150\/thno.94855","volume":"14","author":"P Ma","year":"2024","unstructured":"Ma P, Luo Z, Wang Q et al (2024) Combined activation of artificial and natural ion channels for disrupting mitochondrial ion homeostasis towards effective postoperative tumor recurrence and metastasis suppression. Theranostics 14:3282\u20133299. https:\/\/doi.org\/10.7150\/thno.94855","journal-title":"Theranostics"},{"key":"1228_CR241","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1186\/s12951-024-02827-4","volume":"22","author":"Y Wu","year":"2024","unstructured":"Wu Y, Bao H, Wu J et al (2024) ACYP2 functions as an innovative nano-therapeutic target to impede the progression of hepatocellular carcinoma by inhibiting the activity of TERT and the KCNN4\/ERK pathway. J Nanobiotechnol 22:557. https:\/\/doi.org\/10.1186\/s12951-024-02827-4","journal-title":"J Nanobiotechnol"},{"key":"1228_CR242","doi-asserted-by":"publisher","first-page":"1013324","DOI":"10.3389\/fonc.2022.1013324","volume":"12","author":"R Zeng","year":"2022","unstructured":"Zeng R, Li Y, He D et al (2022) Potassium channel-related genes are a novel prognostic signature for the tumor microenvironment of renal clear cell carcinoma. Front Oncol 12:1013324. https:\/\/doi.org\/10.3389\/fonc.2022.1013324","journal-title":"Front Oncol"},{"key":"1228_CR243","doi-asserted-by":"publisher","first-page":"16437","DOI":"10.18632\/aging.103710","volume":"12","author":"J Wen","year":"2020","unstructured":"Wen J, Lin B, Lin L et al (2020) KCNN4 is a diagnostic and prognostic biomarker that promotes papillary thyroid cancer progression. Aging 12:16437\u201316456. https:\/\/doi.org\/10.18632\/aging.103710","journal-title":"Aging"},{"key":"1228_CR244","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.1093\/annonc\/mdz116","volume":"30","author":"C Luchini","year":"2019","unstructured":"Luchini C, Bibeau F, Ligtenberg MJL et al (2019) ESMO recommendations on microsatellite instability testing for immunotherapy in cancer, and its relationship with PD-1\/PD-L1 expression and tumour mutational burden: A systematic review-based approach. Ann Oncol 30:1232\u20131243. https:\/\/doi.org\/10.1093\/annonc\/mdz116","journal-title":"Ann Oncol"},{"key":"1228_CR245","doi-asserted-by":"publisher","first-page":"1483454","DOI":"10.3389\/fonc.2024.1483454","volume":"14","author":"X Yin","year":"2024","unstructured":"Yin X, Song Y, Deng W et al (2024) Potential predictive biomarkers in antitumor immunotherapy: Navigating the future of antitumor treatment and immune checkpoint inhibitor efficacy. Front Oncol 14:1483454. https:\/\/doi.org\/10.3389\/fonc.2024.1483454","journal-title":"Front Oncol"},{"key":"1228_CR246","doi-asserted-by":"publisher","first-page":"812815","DOI":"10.3389\/fmolb.2022.812815","volume":"9","author":"S Chen","year":"2022","unstructured":"Chen S, Su X, Mo Z (2022) KCNN4 is a potential biomarker for predicting cancer prognosis and an essential molecule that remodels various components in the tumor microenvironment: A pan-cancer study. Front Mol Biosci 9:812815. https:\/\/doi.org\/10.3389\/fmolb.2022.812815","journal-title":"Front Mol Biosci"},{"key":"1228_CR247","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s12859-023-05180-9","volume":"24","author":"Z Zheng","year":"2023","unstructured":"Zheng Z, Song Y (2023) Integrated analysis of the voltage-gated potassium channel-associated gene KCNH2 across cancers. BMC Bioinformatics 24:51. https:\/\/doi.org\/10.1186\/s12859-023-05180-9","journal-title":"BMC Bioinformatics"},{"key":"1228_CR248","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.3892\/mmr.2018.9107","volume":"18","author":"X Liu","year":"2018","unstructured":"Liu X, Wei L, Zhao B et al (2018) Low expression of KCNN3 may affect drug resistance in ovarian cancer. Mol Med Rep 18:1377\u20131386. https:\/\/doi.org\/10.3892\/mmr.2018.9107","journal-title":"Mol Med Rep"},{"key":"1228_CR249","doi-asserted-by":"publisher","first-page":"913","DOI":"10.3389\/fphar.2020.00913","volume":"11","author":"A D\u00edaz-Garc\u00eda","year":"2020","unstructured":"D\u00edaz-Garc\u00eda A, Varela D (2020) Voltage-gated K+\/ Na+ channels and scorpion venom toxins in cancer. Front Pharmacol 11:913. https:\/\/doi.org\/10.3389\/fphar.2020.00913","journal-title":"Front Pharmacol"},{"key":"1228_CR250","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/j.ejphar.2014.06.044","volume":"741","author":"H Nogawa","year":"2014","unstructured":"Nogawa H, Kawai T (2014) hERG trafficking inhibition in drug-induced lethal cardiac arrhythmia. Eur J Pharmacol 741:336\u2013339. https:\/\/doi.org\/10.1016\/j.ejphar.2014.06.044","journal-title":"Eur J Pharmacol"},{"key":"1228_CR251","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1080\/14728222.2024.2318449","volume":"28","author":"A Arcangeli","year":"2024","unstructured":"Arcangeli A, Iorio J, Duranti C (2024) Targeting the hERG1 and \u03b21 integrin complex for cancer treatment. Expert Opin Ther Targets 28:145\u2013157. https:\/\/doi.org\/10.1080\/14728222.2024.2318449","journal-title":"Expert Opin Ther Targets"},{"key":"1228_CR252","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/1476-4598-5-41","volume":"5","author":"B Hemmerlein","year":"2006","unstructured":"Hemmerlein B, Weseloh RM, Mello de Queiroz F et al (2006) Overexpression of Eag1 potassium channels in clinical tumours. Mol Cancer 5:41. https:\/\/doi.org\/10.1186\/1476-4598-5-41","journal-title":"Mol Cancer"},{"key":"1228_CR253","doi-asserted-by":"publisher","first-page":"5986","DOI":"10.3390\/s120505986","volume":"12","author":"JA Rodr\u00edguez-Rasgado","year":"2012","unstructured":"Rodr\u00edguez-Rasgado JA, Acu\u00f1a-Mac\u00edas I, Camacho J (2012) Eag1 channels as potential cancer biomarkers. Sens (Basel) 12:5986\u20135995. https:\/\/doi.org\/10.3390\/s120505986","journal-title":"Sens (Basel)"},{"key":"1228_CR254","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1002\/med.21808","volume":"42","author":"\u017d Toplak","year":"2022","unstructured":"Toplak \u017d, Hendrickx LA, Abdelaziz R et al (2022) Overcoming challenges of HERG potassium channel liability through rational design: Eag1 inhibitors for cancer treatment. Med Res Rev 42:183\u2013226. https:\/\/doi.org\/10.1002\/med.21808","journal-title":"Med Res Rev"},{"key":"1228_CR255","doi-asserted-by":"publisher","first-page":"16285","DOI":"10.3390\/ijms242216285","volume":"24","author":"P Zuccolini","year":"2023","unstructured":"Zuccolini P, Barbieri R, Sbrana F et al (2023) IK channel-independent effects of clotrimazole and senicapoc on cancer cells viability and migration. Int J Mol Sci 24:16285. https:\/\/doi.org\/10.3390\/ijms242216285","journal-title":"Int J Mol Sci"},{"key":"1228_CR256","doi-asserted-by":"publisher","first-page":"115635","DOI":"10.1016\/j.biopha.2023.115635","volume":"168","author":"C Cammann","year":"2023","unstructured":"Cammann C, Kulla J, Wiebusch L et al (2023) Proteasome inhibition potentiates Kv1.3 potassium channel expression as therapeutic target in drug-sensitive and -resistant human melanoma cells. Biomed Pharmacother 168:115635. https:\/\/doi.org\/10.1016\/j.biopha.2023.115635","journal-title":"Biomed Pharmacother"}],"container-title":["Journal of Physiology and Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13105-026-01228-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13105-026-01228-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13105-026-01228-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T13:59:36Z","timestamp":1788271176000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13105-026-01228-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,1]]},"references-count":256,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["1228"],"URL":"https:\/\/doi.org\/10.1007\/s13105-026-01228-5","relation":{},"ISSN":["1138-7548","1877-8755"],"issn-type":[{"value":"1138-7548","type":"print"},{"value":"1877-8755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,1]]},"assertion":[{"value":"13 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Patient consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"87"}}