{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:22:52Z","timestamp":1792783372175,"version":"4.5.0"},"reference-count":126,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:00:00Z","timestamp":1790985600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:00:00Z","timestamp":1790985600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"National College Student Innovation Training Program-Key Supported Field Project","award":["202510716001"],"award-info":[{"award-number":["202510716001"]}]},{"name":"Shaanxi University of Chinese Medicine \u201cQingmiao Program\u201d Project","award":["2025QZ24"],"award-info":[{"award-number":["2025QZ24"]}],"id":[{"id":"https:\/\/ror.org\/021r98132","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Science Foundation of China","award":["31100834"],"award-info":[{"award-number":["31100834"]}]},{"name":"Science Foundation of Shaanxi Province","award":["2020JM-011"],"award-info":[{"award-number":["2020JM-011"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Physiol Biochem"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s13105-026-01237-4","type":"journal-article","created":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T07:30:56Z","timestamp":1791012656000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Programmed cell death protein 4 (PDCD4): a pleiotropic regulator in cardiovascular diseases"],"prefix":"10.1007","volume":"82","author":[{"given":"Mingbo","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1944-3114","authenticated-orcid":false,"given":"Xiaoying","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,3]]},"reference":[{"key":"1237_CR1","doi-asserted-by":"publisher","first-page":"115235","DOI":"10.1016\/j.bcp.2022.115235","volume":"204","author":"O Habimana","year":"2022","unstructured":"Habimana O, Modupe Salami O, Peng J, Yi GH (2022) Therapeutic implications of targeting pyroptosis in cardiac-related etiology of heart failure. Biochem Pharmacol 204:115235","journal-title":"Biochem Pharmacol"},{"key":"1237_CR2","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14040711","volume":"14","author":"D Gonciar","year":"2022","unstructured":"Gonciar D, Mocan T, Agoston-Coldea L (2022) Nanoparticles targeting the molecular pathways of heart remodeling and regeneration. Pharmaceutics 14:711","journal-title":"Pharmaceutics"},{"key":"1237_CR3","doi-asserted-by":"publisher","first-page":"1396","DOI":"10.3390\/ph17101396","volume":"17","author":"Q Wang","year":"2024","unstructured":"Wang Q, Yang HS (2024) The impact of Pdcd4, a translation inhibitor, on drug resistance. Pharmaceuticals (Basel) 17:1396","journal-title":"Pharmaceuticals (Basel)"},{"key":"1237_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.carpath.2024.107673","volume":"73","author":"A Fatehi Hassanabad","year":"2024","unstructured":"Fatehi Hassanabad A, Zarzycki AN, Patel VB, Fedak PWM (2024) Current concepts in the epigenetic regulation of cardiac fibrosis. Cardiovasc Pathol 73:107673","journal-title":"Cardiovasc Pathol"},{"key":"1237_CR5","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20092304","volume":"20","author":"S Matsuhashi","year":"2019","unstructured":"Matsuhashi S, Manirujjaman M, Hamajima H, Ozaki I (2019) Control mechanisms of the tumor suppressor PDCD4: expression and functions. Int J Mol Sci 20:2304","journal-title":"Int J Mol Sci"},{"key":"1237_CR6","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.855807","volume":"12","author":"Q Cai","year":"2022","unstructured":"Cai Q, Yang HS, Li YC, Zhu J (2022) Dissecting the roles of PDCD4 in breast cancer. Front Oncol 12:855807","journal-title":"Front Oncol"},{"key":"1237_CR7","doi-asserted-by":"publisher","first-page":"3274","DOI":"10.1073\/pnas.0712235105","volume":"105","author":"C Suzuki","year":"2008","unstructured":"Suzuki C, Garces RG, Edmonds KA et al (2008) PDCD4 inhibits translation initiation by binding to eIF4A using both its MA3 domains. Proc Natl Acad Sci U S A 105:3274\u20133279","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1237_CR8","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.freeradbiomed.2020.06.016","volume":"159","author":"K Lu","year":"2020","unstructured":"Lu K, Chen Q, Li M et al (2020) Programmed cell death factor 4 (PDCD4), a novel therapy target for metabolic diseases besides cancer. Free Radic Biol Med 159:150\u2013163","journal-title":"Free Radic Biol Med"},{"key":"1237_CR9","unstructured":"NCBI Gene (2026) PDCD4 programmed cell death 4 [Homo sapiens]. Gene ID: 27250. Updated April 8, 2026"},{"key":"1237_CR10","unstructured":"OriGene Technologies (n.d.) PDCD4 (NM_014456) Human Untagged Clone (SC111794). RefSeq size 3591 bp; RefSeq ORF 1410 bp; cytogenetics 10q25.2"},{"key":"1237_CR11","unstructured":"UniProtKB (n.d.) Q53EL6 (PDCD4_HUMAN), programmed cell death protein 4. Length 469 aa; mass 51,735"},{"key":"1237_CR12","unstructured":"NCBI Gene (2026) Pdcd4 programmed cell death 4 [Mus musculus]. Gene ID: 18569. Updated April 8, 2026"},{"key":"1237_CR13","unstructured":"OriGene Technologies (n.d.) Mouse Pdcd4 (NM_011050) AAV Particle (MR217744A1V). RefSeq size 2418 bp; RefSeq ORF 1410 bp; cytogenetics 19 48.73"},{"key":"1237_CR14","unstructured":"NCBI Gene (n.d.) Pdcd4 programmed cell death 4 [Rattus norvegicus]. Gene ID: 64031. Current annotation: chromosome 1q55, 17"},{"key":"1237_CR15","unstructured":"NCBI Nucleotide (n.d.) Rattus norvegicus programmed cell death 4 (Pdcd4), mRNA. RefSeq: NM_022265.3"},{"key":"1237_CR16","unstructured":"UniProtKB (n.d.) B3DM93 \/ Q9JID1, programmed cell death protein 4, Rattus norvegicus. Length 469 aa; mass 51,736"},{"key":"1237_CR17","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1128\/MCB.00867-06","volume":"27","author":"N LaRonde-LeBlanc","year":"2007","unstructured":"LaRonde-LeBlanc N, Santhanam AN, Baker AR, Wlodawer A, Colburn NH (2007) Structural basis for inhibition of translation by the tumor suppressor Pdcd4. Mol Cell Biol 27:147\u2013156","journal-title":"Mol Cell Biol"},{"key":"1237_CR18","doi-asserted-by":"publisher","first-page":"3148","DOI":"10.1073\/pnas.0808275106","volume":"106","author":"JH Chang","year":"2009","unstructured":"Chang JH, Cho YH, Sohn SY, Choi JM, Kim A, Kim YC, Jang SK, Cho Y (2009) Crystal structure of the eIF4A-PDCD4 complex. Proc Natl Acad Sci U S A 106:3148\u20133153","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1237_CR19","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.biopha.2018.03.071","volume":"102","author":"Q Wang","year":"2018","unstructured":"Wang Q, Yang HS (2018) The role of Pdcd4 in tumor suppression and protein translation. Biomed Pharmacother 102:302\u2013308","journal-title":"Biomed Pharmacother"},{"key":"1237_CR20","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.freeradbiomed.2020.06.016","volume":"159","author":"K Lu","year":"2020","unstructured":"Lu K, Chen Q, Li M, He L, Riaz F, Zhang T, Li D (2020) Programmed cell death factor 4 (PDCD4), a novel therapy target for metabolic diseases besides cancer. Free Radic Biol Med 159:150\u2013163","journal-title":"Free Radic Biol Med"},{"key":"1237_CR21","doi-asserted-by":"publisher","first-page":"4257","DOI":"10.1111\/j.1582-4934.2008.00497.x","volume":"13","author":"F Gao","year":"2009","unstructured":"Gao F, Wang X, Zhu F, Wang Q, Zhang X, Guo C et al (2009) PDCD4 gene silencing in gliomas is associated with 5\u2032CpG island methylation and unfavorable prognosis. J Cell Mol Med 13:4257\u20134267","journal-title":"J Cell Mol Med"},{"key":"1237_CR22","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1007\/s00432-011-1140-8","volume":"138","author":"Z Cao","year":"2012","unstructured":"Cao Z, Yoon JH, Nam SW, Lee JY, Park WS (2012) PDCD4 expression inversely correlated with miR-21 levels in gastric cancers. J Cancer Res Clin Oncol 138:611\u2013619","journal-title":"J Cancer Res Clin Oncol"},{"key":"1237_CR23","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002729","volume":"95","author":"X Ding","year":"2016","unstructured":"Ding X, Cheng X, Gong M, Chen X, Yin F, Lai K (2016) Hypermethylation and expression silencing of PDCD4 gene in hepatocellular carcinoma: a consort study. Medicine (Baltimore) 95:e2729","journal-title":"Medicine (Baltimore)"},{"key":"1237_CR24","first-page":"942","volume":"47","author":"BA He","year":"2020","unstructured":"He BA, Peng Q, Zhu Y (2020) Expression and methylation of PDCD4 in gastric carcinoma and its clinical significance. Cancer Res Prev Treat 47:942\u2013946","journal-title":"Cancer Res Prev Treat"},{"key":"1237_CR25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046215","volume":"7","author":"S Spisak","year":"2012","unstructured":"Spisak S, Kalmar A, Galamb O, Wichmann B, Sipos F, Peterfia B et al (2012) Genome-wide screening of genes regulated by DNA methylation in colon cancer development. PLoS ONE 7:e46215","journal-title":"PLoS ONE"},{"key":"1237_CR26","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1186\/s12906-019-2504-x","volume":"19","author":"Y Zhu","year":"2019","unstructured":"Zhu Y, Liu L, Hu L, Dong W, Zhang M, Liu Y, Li P (2019) Effect of Celastrus orbiculatus in inhibiting Helicobacter pylori induced inflammatory response by regulating epithelial mesenchymal transition and targeting miR-21\/PDCD4 signaling pathway in gastric epithelial cells. BMC Complement Altern Med 19:91","journal-title":"BMC Complement Altern Med"},{"key":"1237_CR27","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1080\/09513590.2019.1653844","volume":"36","author":"X Qiu","year":"2020","unstructured":"Qiu X, Wei Y, Liu C, Ding C (2020) Hyperandrogen enhances apoptosis of human ovarian granulosa cells via up-regulation and demethylation of PDCD4. Gynecol Endocrinol 36:333\u2013337","journal-title":"Gynecol Endocrinol"},{"key":"1237_CR28","doi-asserted-by":"publisher","first-page":"5170","DOI":"10.3892\/ol.2016.5323","volume":"12","author":"YA Chen","year":"2016","unstructured":"Chen YA, Bian Y, Zhao S, Kong F, Li XG (2016) Suppression of PDCD4 mediated by the long non-coding RNA HOTAIR inhibits the proliferation and invasion of glioma cells. Oncol Lett 12:5170\u20135176","journal-title":"Oncol Lett"},{"key":"1237_CR29","doi-asserted-by":"publisher","first-page":"509","DOI":"10.3892\/ijo.2016.3571","volume":"49","author":"K Fang","year":"2016","unstructured":"Fang K, Liu P, Dong S, Guo Y, Cui X, Zhu X et al (2016) Magnetofection based on superparamagnetic iron oxide nanoparticle-mediated low lncRNA HOTAIR expression decreases the proliferation and invasion of glioma stem cells. Int J Oncol 49:509\u2013518","journal-title":"Int J Oncol"},{"key":"1237_CR30","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1186\/s12943-017-0715-7","volume":"16","author":"Y Wu","year":"2017","unstructured":"Wu Y, Hu L, Liang Y, Li J, Wang K, Chen X, Meng H, Guan X, Yang K, Bai Y (2017) Up-regulation of lncRNA CASC9 promotes esophageal squamous cell carcinoma growth by negatively regulating PDCD4 expression through EZH2. Mol Cancer 16:150","journal-title":"Mol Cancer"},{"key":"1237_CR31","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/s13578-018-0260-0","volume":"8","author":"C Xu","year":"2018","unstructured":"Xu C, Guo Y, Liu H, Chen G, Yan Y, Liu T (2018) TUG1 confers cisplatin resistance in esophageal squamous cell carcinoma by epigenetically suppressing PDCD4 expression via EZH2. Cell Biosci 8:61","journal-title":"Cell Biosci"},{"key":"1237_CR32","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1007\/s13277-014-2630-5","volume":"36","author":"Y Huang","year":"2015","unstructured":"Huang Y, Liu Y, Yu L, Chen J, Hou J, Cui L et al (2015) Histone demethylase KDM2A promotes tumor cell growth and migration in gastric cancer. Tumour Biol 36:271\u2013278","journal-title":"Tumour Biol"},{"key":"1237_CR33","doi-asserted-by":"publisher","first-page":"129","DOI":"10.4161\/epi.26842","volume":"9","author":"A Ferraro","year":"2014","unstructured":"Ferraro A, Kontos CK, Boni T, Bantounas L, Siakouli D, Kosmidou V et al (2014) Epigenetic regulation of miR-21 in colorectal cancer: ITGB4 as a novel miR-21 target and a three-gene network (miR-21-ITGbeta4-PDCD4) as predictor of metastatic potential. Epigenetics 9:129\u2013141","journal-title":"Epigenetics"},{"key":"1237_CR34","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.18632\/oncotarget.2859","volume":"6","author":"M Zhou","year":"2015","unstructured":"Zhou M et al (2015) Histone demethylase RBP2 decreases miR-21 in blast crisis of chronic myeloid leukemia. Oncotarget 6:1249\u20131261","journal-title":"Oncotarget"},{"key":"1237_CR35","first-page":"1029","volume":"18","author":"J Zhang","year":"2021","unstructured":"Zhang J, Luo CJ, Xiong XQ, Li J, Tang SH, Sun LJ et al (2021) MiR-21-5p-expressing bone marrow mesenchymal stem cells alleviate myocardial ischemia\/reperfusion injury by regulating the circRNA_0031672\/miR-21-5p\/programmed cell death protein 4 pathway. J Geriatr Cardiol 18:1029\u20131043","journal-title":"J Geriatr Cardiol"},{"key":"1237_CR36","doi-asserted-by":"publisher","first-page":"4237","DOI":"10.1128\/MCB.00443-12","volume":"32","author":"YM Park","year":"2012","unstructured":"Park YM, Hwang SJ, Masuda K, Choi KM, Jeong MR, Nam DH, Gorospe M, Kim HH (2012) Heterogeneous nuclear ribonucleoprotein C1\/C2 controls the metastatic potential of glioblastoma by regulating PDCD4. Mol Cell Biol 32:4237\u20134244","journal-title":"Mol Cell Biol"},{"key":"1237_CR37","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1038\/sj.onc.1204071","volume":"20","author":"U Schlichter","year":"2001","unstructured":"Schlichter U, Burk O, Worpenberg S, Klempnauer KH (2001) The chicken Pdcd4 gene is regulated by v-Myb. Oncogene 20:231\u2013239","journal-title":"Oncogene"},{"key":"1237_CR38","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/S0167-4781(01)00252-4","volume":"1520","author":"U Schlichter","year":"2001","unstructured":"Schlichter U, Kattmann D, Appl H, Miethe J, Brehmer-Fastnacht A, Klempnauer KH (2001) Identification of the myb-inducible promoter of the chicken Pdcd4 gene. Biochim Biophys Acta 1520:99\u2013104","journal-title":"Biochim Biophys Acta"},{"key":"1237_CR39","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1002\/humu.22340","volume":"34","author":"A Binia","year":"2013","unstructured":"Binia A, Khorasani N, Bhavsar PK, Adcock I, Brightling CE, Chung KF, Moffatt MF, Cookson WOCM, Hall IP, Sayers I (2013) A polymorphism affecting MYB binding within the promoter of the PDCD4 gene is associated with severe asthma in children. Hum Mutat 34:1131\u20131139","journal-title":"Hum Mutat"},{"key":"1237_CR40","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1042\/BSR20110045","volume":"32","author":"JH Leupold","year":"2012","unstructured":"Leupold JH, Asangani IA, Mudduluru G, Allgayer H (2012) Promoter cloning and characterization of the human programmed cell death protein 4 (PDCD4) gene: evidence for ZBP-89 and Sp-binding motifs as essential PDCD4 regulators. Biosci Rep 32:281\u2013297","journal-title":"Biosci Rep"},{"key":"1237_CR41","doi-asserted-by":"publisher","first-page":"7437","DOI":"10.1093\/nar\/gkab575","volume":"49","author":"L Coronel","year":"2021","unstructured":"Coronel L, Riege K, Schwab K, F\u00f6rste S, H\u00e4ckes D, Semerau L, Bernhart SH, Siebert R, Hoffmann S, Fischer M (2021) Transcription factor RFX7 governs a tumor suppressor network in response to p53 and stress. Nucleic Acids Res 49:7437\u20137456","journal-title":"Nucleic Acids Res"},{"key":"1237_CR42","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1038\/s41420-024-02149-2","volume":"10","author":"K Schwab","year":"2024","unstructured":"Schwab K, Riege K, Coronel L, Fischer M (2024) p53 target ANKRA2 cooperates with RFX7 to regulate tumor suppressor genes. Cell Death Discov 10:376","journal-title":"Cell Death Discov"},{"key":"1237_CR43","doi-asserted-by":"publisher","first-page":"8135","DOI":"10.1038\/sj.onc.1207983","volume":"23","author":"O Afonja","year":"2004","unstructured":"Afonja O, Juste D, Das S, Matsuhashi S, Samuels HH (2004) Induction of PDCD4 tumor suppressor gene expression by RAR agonists, antiestrogen and HER-2\/neu antagonist in breast cancer cells: evidence for a role in apoptosis. Oncogene 23:8135\u20138145","journal-title":"Oncogene"},{"key":"1237_CR44","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1007\/s12672-020-00392-4","volume":"11","author":"S Madera","year":"2020","unstructured":"Madera S, Chervo MF, Chiauzzi VA, Pereyra MG, Venturutti L, Izzo F et al (2020) Nuclear PDCD4 expression defines a subset of luminal B-like breast cancers with good prognosis. Horm Cancer 11:218\u2013239","journal-title":"Horm Cancer"},{"key":"1237_CR45","doi-asserted-by":"publisher","first-page":"6101","DOI":"10.1038\/sj.onc.1209634","volume":"25","author":"H Zhang","year":"2006","unstructured":"Zhang H, Ozaki I, Mizuta T, Hamajima H, Yasutake T, Eguchi Y, Ideguchi H, Yamamoto K, Matsuhashi S (2006) Involvement of programmed cell death 4 in transforming growth factor-beta1-induced apoptosis in human hepatocellular carcinoma. Oncogene 25:6101\u20136112","journal-title":"Oncogene"},{"key":"1237_CR46","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0098080","volume":"9","author":"AK Riar","year":"2014","unstructured":"Riar AK, Narasimhan M, Rathinam ML, Vedpathak D, Mummidi S, Henderson GI, Mahimainathan L (2014) Ethanol-induced transcriptional activation of programmed cell death 4 (Pdcd4) is mediated by GSK-3\u03b2 signaling in rat cortical neuroblasts. PLoS ONE 9:e98080","journal-title":"PLoS ONE"},{"key":"1237_CR47","doi-asserted-by":"publisher","first-page":"8","DOI":"10.3390\/ijms17010008","volume":"17","author":"T Wang","year":"2016","unstructured":"Wang T, Li X, Zheng X et al (2016) Cell density-dependent upregulation of PDCD4 in keratinocytes and its implications for epidermal homeostasis and repair. Int J Mol Sci 17:8","journal-title":"Int J Mol Sci"},{"key":"1237_CR48","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.00542","volume":"2","author":"CM Olson","year":"2013","unstructured":"Olson CM, Donovan MR, Spellberg MJ, Marr MT II (2013) The insulin receptor cellular IRES confers resistance to eIF4A inhibition. Elife 2:e00542. https:\/\/doi.org\/10.7554\/eLife.00542","journal-title":"Elife"},{"key":"1237_CR49","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.1038\/cdd.2017.102","volume":"24","author":"H Lingel","year":"2017","unstructured":"Lingel H, Wissing J, Arra A, Schanze D, Lienenklaus S, Klawonn F, Pierau M, Zenker M, J\u00e4nsch L, Brunner-Weinzierl MC (2017) CTLA-4-mediated posttranslational modifications direct cytotoxic T-lymphocyte differentiation. Cell Death Differ 24:1739\u20131749. https:\/\/doi.org\/10.1038\/cdd.2017.102","journal-title":"Cell Death Differ"},{"key":"1237_CR50","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.bbagrm.2013.12.001","volume":"1839","author":"PN Vikhreva","year":"2014","unstructured":"Vikhreva PN, Shepelev MV, Korobko IV (2014) MTOR-dependent transcriptional repression of Pdcd4 tumor suppressor in lung cancer cells. Biochim Biophys Acta Gene Regul Mech 1839:43\u201349","journal-title":"Biochim Biophys Acta Gene Regul Mech"},{"key":"1237_CR51","doi-asserted-by":"publisher","first-page":"17450","DOI":"10.1073\/pnas.1901765116","volume":"116","author":"S Hashimoto","year":"2019","unstructured":"Hashimoto S, Furukawa S, Hashimoto A, Tsutaho A, Fukao A, Sakamura Y et al (2019) ARF6 and AMAP1 are major targets of KRAS and TP53 mutations to promote invasion, PD-L1 dynamics, and immune evasion of pancreatic cancer. Proc Natl Acad Sci U S A 116:17450\u201317459","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1237_CR52","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2024.111178","volume":"119","author":"MT Khan","year":"2024","unstructured":"Khan MT, Almas M, Malik N, Jalota A, Sharma S, Ali SA, Luthra K, Suri V, Suri A, Basak S, Seth P, Chosdol K, Sinha S (2024) STAT1 mediated downregulation of the tumor suppressor gene PDCD4, is driven by the atypical cadherin FAT1, in glioblastoma. Cell Signal 119:111178","journal-title":"Cell Signal"},{"key":"1237_CR53","doi-asserted-by":"publisher","first-page":"463","DOI":"10.3892\/mmr.2015.3398","volume":"12","author":"YY Shang","year":"2015","unstructured":"Shang YY, Fang NN, Wang F, Wang H, Wang ZH, Tang MX et al (2015) MicroRNA-21, induced by high glucose, modulates macrophage apoptosis via programmed cell death 4. Mol Med Rep 12:463\u2013469","journal-title":"Mol Med Rep"},{"key":"1237_CR54","first-page":"10075","volume":"10","author":"X Xu","year":"2017","unstructured":"Xu X et al (2017) MiR-21 suppresses ox-LDL-induced HUVECs apoptosis by targeting PDCD4. Int J Clin Exp Pathol 10:10075\u201310084","journal-title":"Int J Clin Exp Pathol"},{"key":"1237_CR55","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.yjmcc.2009.01.008","volume":"47","author":"Y Cheng","year":"2009","unstructured":"Cheng Y, Liu X, Zhang S, Lin Y, Yang J, Zhang C (2009) MicroRNA-21 protects against the H2O2-induced injury on cardiac myocytes via its target gene PDCD4. J Mol Cell Cardiol 47:5\u201314","journal-title":"J Mol Cell Cardiol"},{"key":"1237_CR56","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1093\/cvr\/cvq082","volume":"87","author":"Y Cheng","year":"2010","unstructured":"Cheng Y, Zhu P, Yang J, Liu X, Dong S, Wang X et al (2010) Ischaemic preconditioning-regulated miR-21 protects heart against ischaemia\/reperfusion injury via anti-apoptosis through its target PDCD4. Cardiovasc Res 87:431\u2013439","journal-title":"Cardiovasc Res"},{"key":"1237_CR57","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1080\/15384101.2020.1750257","volume":"19","author":"XH Zhou","year":"2020","unstructured":"Zhou XH, Chai HX, Bai M, Zhang Z (2020) LncRNA-GAS5 regulates PDCD4 expression and mediates myocardial infarction-induced cardiomyocytes apoptosis via targeting MiR-21. Cell Cycle (Georget) 19:1363\u20131377","journal-title":"Cell Cycle (Georget)"},{"key":"1237_CR58","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1161\/HYPERTENSIONAHA.113.03037","volume":"64","author":"K White","year":"2014","unstructured":"White K, Dempsie Y, Caruso P, Wallace E, McDonald RA, Stevens H et al (2014) Endothelial apoptosis in pulmonary hypertension is controlled by a microRNA\/programmed cell death 4\/caspase-3 axis. Hypertension 64:185\u2013194","journal-title":"Hypertension"},{"key":"1237_CR59","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003441","volume":"4","author":"L Maegdefessel","year":"2012","unstructured":"Maegdefessel L, Azuma J, Toh R, Deng A, Merk DR, Raiesdana A, Leeper NJ, Raaz U, Schoelmerich AM, McConnell MV, Dalman RL, Spin JM, Tsao PS (2012) MicroRNA-21 blocks abdominal aortic aneurysm development and nicotine-augmented expansion. Sci Transl Med 4:122ra22","journal-title":"Sci Transl Med"},{"key":"1237_CR60","doi-asserted-by":"publisher","first-page":"90","DOI":"10.3892\/ijmm.2021.4923","volume":"47","author":"Q Yu","year":"2021","unstructured":"Yu Q, Li Q, Yang X, Liu Q, Deng J, Zhao Y, Hu R, Dai M (2021) Dexmedetomidine suppresses the development of abdominal aortic aneurysm by downregulating the microRNA-21\/PDCD4 axis. Int J Mol Med 47:90","journal-title":"Int J Mol Med"},{"key":"1237_CR61","doi-asserted-by":"publisher","first-page":"339","DOI":"10.4161\/rna.28300","volume":"11","author":"J Wang","year":"2014","unstructured":"Wang J, Jia Z, Zhang C, Sun M, Wang W, Chen P et al (2014) MiR-499 protects cardiomyocytes from H2O2-induced apoptosis via its effects on Pdcd4 and Pacs2. RNA Biol 11:339\u2013350","journal-title":"RNA Biol"},{"key":"1237_CR62","doi-asserted-by":"publisher","first-page":"35607","DOI":"10.18632\/oncotarget.9597","volume":"7","author":"Y Li","year":"2016","unstructured":"Li Y, Lu J, Bao X, Wang X, Wu J, Li X, Hong W (2016) MiR-499-5p protects cardiomyocytes against ischemic injury via anti-apoptosis by targeting PDCD4. Oncotarget 7:35607\u201335617","journal-title":"Oncotarget"},{"key":"1237_CR63","doi-asserted-by":"publisher","first-page":"2364","DOI":"10.1159\/000452506","volume":"39","author":"J Zhu","year":"2016","unstructured":"Zhu J, Yao K, Wang Q, Guo J, Shi H, Ma L et al (2016) Ischemic postconditioning-regulated miR-499 protects the rat heart against ischemia\/reperfusion injury by inhibiting apoptosis through PDCD4. Cell Physiol Biochem 39:2364\u20132380","journal-title":"Cell Physiol Biochem"},{"key":"1237_CR64","doi-asserted-by":"publisher","first-page":"967","DOI":"10.3892\/ijmm.2016.2497","volume":"37","author":"X Liang","year":"2016","unstructured":"Liang X, Xu Z, Yuan M, Zhang Y, Zhao B, Wang J et al (2016) MicroRNA-16 suppresses the activation of inflammatory macrophages in atherosclerosis by targeting PDCD4. Int J Mol Med 37:967\u2013975","journal-title":"Int J Mol Med"},{"key":"1237_CR65","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1186\/s12951-026-04091-0","volume":"24","author":"Z Wang","year":"2026","unstructured":"Wang Z, Shi J, Liang Y, Li D, Luo Y, Zhang Y, Chen Y, Li N, Gai X, Sun Y (2026) COPD airway epithelial cells-derived extracellular vesicles contribute to endothelial dysfunction and atherosclerosis via the miR-141-3p\/PDCD4 axis. J Nanobiotechnology 24:220","journal-title":"J Nanobiotechnology"},{"key":"1237_CR66","doi-asserted-by":"publisher","first-page":"283","DOI":"10.3233\/CH-231696","volume":"87","author":"H Lin","year":"2024","unstructured":"Lin H, Gao D, Wang S, Wang Z, Guan H, Wang Y, Zhou Y (2024) Inhibition of circ_0000231 suppresses oxidized low density lipoprotein-induced apoptosis, autophagy and inflammation in human umbilical vein endothelial cells by regulating miR-590-5p\/PDCD4 axis. Clin Hemorheol Microcirc 87:283\u2013299","journal-title":"Clin Hemorheol Microcirc"},{"key":"1237_CR67","first-page":"5003","volume":"9","author":"H Xu","year":"2017","unstructured":"Xu H, Cao H, Zhu G, Liu S, Li H (2017) Overexpression of microRNA-145 protects against rat myocardial infarction through targeting PDCD4. Am J Transl Res 9:5003\u20135011","journal-title":"Am J Transl Res"},{"key":"1237_CR68","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20190444","volume":"39","author":"Y Chen","year":"2019","unstructured":"Chen Y, Zhang Z, Zhu D, Zhao W, Li F (2019) Long non-coding RNA MEG3 serves as a ceRNA for microRNA-145 to induce apoptosis of AC16 cardiomyocytes under high glucose condition. Biosci Rep 39:BSR20190444","journal-title":"Biosci Rep"},{"key":"1237_CR69","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.23202","volume":"36","author":"Q Wang","year":"2022","unstructured":"Wang Q, Zhou H, Zhu X, Jiang F, Yu Q, Zhang J, Ji Y (2022) MiR-208 inhibits myocardial tissues apoptosis in mice with acute myocardial infarction by targeting inhibition of PDCD4. J Biochem Mol Toxicol 36:e23202","journal-title":"J Biochem Mol Toxicol"},{"key":"1237_CR70","doi-asserted-by":"publisher","first-page":"6638","DOI":"10.1038\/s41598-024-57206-8","volume":"14","author":"J Zhu","year":"2024","unstructured":"Zhu J, Wang Q, Zheng Z, Ma L, Guo J, Shi H et al (2024) MiR-181a protects the heart against myocardial infarction by regulating mitochondrial fission via targeting programmed cell death protein 4. Sci Rep 14:6638","journal-title":"Sci Rep"},{"key":"1237_CR71","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1007\/s00592-021-01713-x","volume":"58","author":"SF Zhao","year":"2021","unstructured":"Zhao SF, Ye YX, Xu JD, He Y, Zhang DW, Xia ZY, Wang S (2021) Long non-coding RNA KCNQ1OT1 increases the expression of PDCD4 by targeting miR-181a-5p, contributing to cardiomyocyte apoptosis in diabetic cardiomyopathy. Acta Diabetol 58:1251\u20131267","journal-title":"Acta Diabetol"},{"key":"1237_CR72","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.gene.2018.06.087","volume":"675","author":"J Ma","year":"2018","unstructured":"Ma J, Zhang J, Wang Y, Long K, Wang X, Jin L, Tang Q, Zhu L, Tang G, Li X et al (2018) MiR-532-5p alleviates hypoxia-induced cardiomyocyte apoptosis by targeting PDCD4. Gene 675:36\u201343. https:\/\/doi.org\/10.1016\/j.gene.2018.06.087","journal-title":"Gene"},{"key":"1237_CR73","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2021.114466","volume":"186","author":"Q Zhang","year":"2021","unstructured":"Zhang Q, Cao Y, Liu Y, Huang W, Ren J, Wang P, Song C, Fan K, Ba L, Wang L, Sun H (2021) Shear stress inhibits cardiac microvascular endothelial cells apoptosis to protect against myocardial ischemia reperfusion injury via YAP\/miR-206\/PDCD4 signaling. Biochem Pharmacol 186:114466","journal-title":"Biochem Pharmacol"},{"key":"1237_CR74","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1016\/j.biopha.2018.12.122","volume":"111","author":"R Sun","year":"2019","unstructured":"Sun R, Zhang L (2019) Long non-coding RNA MALAT1 regulates cardiomyocytes apoptosis after hypoxia\/reperfusion injury via modulating miR-200a-3p\/PDCD4 axis. Biomed Pharmacother 111:1036\u20131045","journal-title":"Biomed Pharmacother"},{"key":"1237_CR75","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.11958\/20230523","volume":"51","author":"C Lyu","year":"2023","unstructured":"Lyu C, Huang T, Xu Z, Liu H, Yang Y, Li Z, Ao W (2023) Impact of LncRNA TUG1 on high glucose-induced cardiomyocyte apoptosis by regulating the miR-181b-5p\/PDCD4 axis. Tianjin Med J 51:1281\u20131287. https:\/\/doi.org\/10.11958\/20230523","journal-title":"Tianjin Med J"},{"key":"1237_CR76","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.1007\/s10753-021-01431-0","volume":"44","author":"SY Ni","year":"2021","unstructured":"Ni SY, Xu WT, Liao GY, Wang YL, Li J (2021) LncRNA HOTAIR promotes LPS-induced inflammation and apoptosis of cardiomyocytes via Lin28-mediated PDCD4 stability. Inflammation 44:1452\u20131463","journal-title":"Inflammation"},{"key":"1237_CR77","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.omtn.2018.08.015","volume":"13","author":"R Wang","year":"2018","unstructured":"Wang R, Zhou S, Wu P, Li M, Ding X, Sun L et al (2018) Identifying involvement of H19-miR-675-3p-IGF1R and H19-miR-200a-PDCD4 in treating pulmonary hypertension with melatonin. Mol Ther Nucleic Acids 13:44\u201354","journal-title":"Mol Ther Nucleic Acids"},{"key":"1237_CR78","doi-asserted-by":"publisher","first-page":"1703","DOI":"10.1038\/onc.2015.235","volume":"35","author":"DK Poria","year":"2016","unstructured":"Poria DK, Guha A, Nandi I, Ray PS (2016) RNA-binding protein HuR sequesters microRNA-21 to prevent translation repression of proinflammatory tumor suppressor PDCD4. Oncogene 35:1703\u20131715","journal-title":"Oncogene"},{"key":"1237_CR79","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1126\/science.1130276","volume":"314","author":"NV Dorrello","year":"2006","unstructured":"Dorrello NV, Peschiaroli A, Guardavaccaro D, Colburn NH, Sherman NE, Pagano M (2006) S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth. Science 314:467\u2013471","journal-title":"Science"},{"key":"1237_CR80","doi-asserted-by":"publisher","first-page":"218","DOI":"10.3390\/cells9010218","volume":"9","author":"M Manirujjaman","year":"2020","unstructured":"Manirujjaman M, Ozaki I, Murata Y, Guo J, Xia J, Nishioka K et al (2020) Degradation of the tumor suppressor PDCD4 is impaired by the suppression of p62\/SQSTM1 and autophagy. Cells 9:218","journal-title":"Cells"},{"key":"1237_CR81","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2024.118616","volume":"399","author":"V Juhasz","year":"2024","unstructured":"Juhasz V, Charlier FT, Zhao TX, Tsiantoulas D (2024) Targeting the adaptive immune continuum in atherosclerosis and post-MI injury. Atherosclerosis 399:118616","journal-title":"Atherosclerosis"},{"key":"1237_CR82","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1038\/cmi.2015.47","volume":"13","author":"Y Jiang","year":"2016","unstructured":"Jiang Y, Gao Q, Wang L, Guo C, Zhu F, Wang B et al (2016) Deficiency of programmed cell death 4 results in increased IL-10 expression by macrophages and thereby attenuates atherosclerosis in hyperlipidemic mice. Cell Mol Immunol 13:524\u2013534","journal-title":"Cell Mol Immunol"},{"key":"1237_CR83","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2015.416","volume":"7","author":"L Wang","year":"2016","unstructured":"Wang L, Jiang Y, Song X, Guo C, Zhu F, Wang X et al (2016) Pdcd4 deficiency enhances macrophage lipoautophagy and attenuates foam cell formation and atherosclerosis in mice. Cell Death Dis 7:e2055","journal-title":"Cell Death Dis"},{"key":"1237_CR84","doi-asserted-by":"publisher","first-page":"7689","DOI":"10.1002\/jcb.28043","volume":"120","author":"S Li","year":"2019","unstructured":"Li S, Gao G, Wu F, Liu D, Zhao H, Ke J et al (2019) Programmed cell death protein 4 deficiency suppresses foam cell formation by activating autophagy in advanced glycation end-product low-density lipoprotein-induced macrophages. J Cell Biochem 120:7689\u20137700","journal-title":"J Cell Biochem"},{"key":"1237_CR85","doi-asserted-by":"publisher","first-page":"8504238","DOI":"10.1155\/2020\/8504238","volume":"2020","author":"M Wang","year":"2020","unstructured":"Wang M, Li J, Cai J, Cheng L, Wang X, Xu P et al (2020) Overexpression of MicroRNA-16 alleviates atherosclerosis by inhibition of inflammatory pathways. Biomed Res Int 2020:8504238","journal-title":"Biomed Res Int"},{"key":"1237_CR86","doi-asserted-by":"publisher","first-page":"8060182","DOI":"10.1155\/2016\/8060182","volume":"2016","author":"J Ye","year":"2016","unstructured":"Ye J, Guo R, Shi Y, Qi F, Guo C, Yang L (2016) miR-155 regulated inflammation response by the SOCS1-STAT3-PDCD4 axis in atherogenesis. Mediators Inflamm 2016:8060182","journal-title":"Mediators Inflamm"},{"key":"1237_CR87","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0091564","volume":"9","author":"C Ge","year":"2014","unstructured":"Ge C, Song J, Chen L, Wang L, Chen Y, Liu X et al (2014) Atheroprotective pulsatile flow induces ubiquitin-proteasome-mediated degradation of programmed cell death 4 in endothelial cells. PLoS ONE 9:e91564","journal-title":"PLoS ONE"},{"key":"1237_CR88","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.ncrna.2025.10.001","volume":"16","author":"J Ren","year":"2025","unstructured":"Ren J, Zou H, Sun S, Chen S, He R, Zhou Q, Tao J, Yang J (2025) MiR-21 modulates P.g-LPS induced apoptosis and inflammatory response in HUVECs via NF-kappaB\/iNOS\/NO pathway by targeting PDCD4. Noncoding RNA Res 16:144\u2013155","journal-title":"Noncoding RNA Res"},{"key":"1237_CR89","doi-asserted-by":"publisher","first-page":"8348430","DOI":"10.1155\/2019\/8348430","volume":"2019","author":"X Xu","year":"2019","unstructured":"Xu X, Zhao Z, Li G (2019) The protective effect of bosentan against atherosclerosis in apolipoprotein E-deficient mice is mediated by miRNA-21. Biomed Res Int 2019:8348430","journal-title":"Biomed Res Int"},{"key":"1237_CR90","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1159\/000493447","volume":"49","author":"Z Shen","year":"2018","unstructured":"Shen Z, She Q (2018) Association between the deletion allele of Ins\/Del polymorphism (rs145204276) in the promoter region of GAS5 with the risk of atherosclerosis. Cell Physiol Biochem 49:1431\u20131443","journal-title":"Cell Physiol Biochem"},{"key":"1237_CR91","doi-asserted-by":"publisher","first-page":"216","DOI":"10.5114\/aoms\/169383","volume":"20","author":"J Pan","year":"2023","unstructured":"Pan J, Wang B, Pu X, Qiu C, Li D, Wu Z, Zhang H, He Y (2023) LncRNA GAPLINC regulates vascular endothelial cell apoptosis in atherosclerosis. Arch Med Sci 20:216\u2013232","journal-title":"Arch Med Sci"},{"key":"1237_CR92","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.3724\/abbs.2022091","volume":"54","author":"X Wang","year":"2022","unstructured":"Wang X, Ma L, Zhang S, Song Q, He X, Wang J (2022) WWP2 ameliorates oxidative stress and inflammation in atherosclerotic mice through regulation of PDCD4\/HO-1 pathway. Acta Biochim Biophys Sin (Shanghai) 54:1057\u20131067","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"1237_CR93","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.1007\/s12012-025-10007-5","volume":"25","author":"Y Chen","year":"2025","unstructured":"Chen Y, Wang Y, Wu T, Guo X, Bai X, Wang L, Yan P, Zheng Z, Xiao L, Li L (2025) Inhibition of USP5 attenuates atherosclerosis by suppressing PDCD4-mediated endothelial dysfunction: evidence from in vitro HUVEC and in vivo models. Cardiovasc Toxicol 25:1272\u20131287","journal-title":"Cardiovasc Toxicol"},{"key":"1237_CR94","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110529","volume":"122","author":"X Fei","year":"2023","unstructured":"Fei X, Cen X, Zhao R, Wang J, Cui H (2023) PRMT5 knockdown enhances cell viability and suppresses cell apoptosis, oxidative stress, inflammation and endothelial dysfunction in ox-LDL-induced vascular endothelial cells via interacting with PDCD4. Int Immunopharmacol 122:110529","journal-title":"Int Immunopharmacol"},{"key":"1237_CR95","doi-asserted-by":"publisher","first-page":"C1481","DOI":"10.1152\/ajpcell.00413.2009","volume":"298","author":"X Liu","year":"2010","unstructured":"Liu X, Cheng Y, Yang J, Krall TJ, Huo Y, Zhang C (2010) An essential role of PDCD4 in vascular smooth muscle cell apoptosis and proliferation: implications for vascular disease. Am J Physiol Cell Physiol 298:C1481\u2013C1488","journal-title":"Am J Physiol Cell Physiol"},{"key":"1237_CR96","first-page":"3150","volume":"17","author":"Y Gao","year":"2019","unstructured":"Gao Y, Li H, Zhou Y, Lv H, Chen Y (2019) PDCD4 expression in coronary atherosclerosis rat models and its mechanism. Exp Ther Med 17:3150\u20133154","journal-title":"Exp Ther Med"},{"key":"1237_CR97","doi-asserted-by":"publisher","first-page":"3976","DOI":"10.1074\/jbc.M111.303156","volume":"287","author":"H Kang","year":"2012","unstructured":"Kang H, Davis-Dusenbery BN, Nguyen PH, Lal A, Lieberman J, Van Aelst L, Lagna G, Hata A (2012) Bone morphogenetic protein 4 promotes vascular smooth muscle contractility by activating microRNA-21, which down-regulates expression of DOCK family proteins. J Biol Chem 287:3976\u20133986","journal-title":"J Biol Chem"},{"key":"1237_CR98","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/nature07086","volume":"454","author":"BN Davis","year":"2008","unstructured":"Davis BN, Hilyard AC, Lagna G, Hata A (2008) SMAD proteins control DROSHA-mediated microRNA maturation. Nature 454:56\u201361","journal-title":"Nature"},{"key":"1237_CR99","doi-asserted-by":"publisher","first-page":"4060","DOI":"10.3390\/cells11244060","volume":"11","author":"HY Tang","year":"2022","unstructured":"Tang HY, Chen AQ, Zhang H, Gao XF, Kong XQ, Zhang JJ (2022) Vascular smooth muscle cells phenotypic switching in cardiovascular diseases. Cells 11:4060","journal-title":"Cells"},{"key":"1237_CR100","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1186\/s12951-023-01985-1","volume":"21","author":"FX Li","year":"2023","unstructured":"Li FX, Liu JJ, Xu F, Shan SK, Zheng MH, Lei LM et al (2023) Cold exposure protects against medial arterial calcification development via autophagy. J Nanobiotechnol 21:226","journal-title":"J Nanobiotechnol"},{"key":"1237_CR101","doi-asserted-by":"publisher","first-page":"29514","DOI":"10.1074\/jbc.M109.027896","volume":"284","author":"S Dong","year":"2009","unstructured":"Dong S, Cheng Y, Yang J, Li J, Liu X, Wang X et al (2009) MicroRNA expression signature and the role of microRNA-21 in the early phase of acute myocardial infarction. J Biol Chem 284:29514\u201329525","journal-title":"J Biol Chem"},{"key":"1237_CR102","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1159\/000338149","volume":"122","author":"X Duan","year":"2012","unstructured":"Duan X, Ji B, Wang X, Liu J, Zheng Z, Long C, Tang Y, Hu S (2012) Expression of microRNA-1 and microRNA-21 in different protocols of ischemic conditioning in an isolated rat heart model. Cardiology 122:36\u201343","journal-title":"Cardiology"},{"key":"1237_CR103","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2016.181","volume":"7","author":"J Xiao","year":"2016","unstructured":"Xiao J, Pan Y, Li XH, Yang XY, Feng YL, Tan HH, Jiang L, Feng J, Yu XY (2016) Cardiac progenitor cell-derived exosomes prevent cardiomyocytes apoptosis through exosomal miR-21 by targeting PDCD4. Cell Death Dis 7:e2277","journal-title":"Cell Death Dis"},{"key":"1237_CR104","doi-asserted-by":"publisher","first-page":"348","DOI":"10.3389\/fphys.2018.00348","volume":"9","author":"H Gu","year":"2018","unstructured":"Gu H, Liu Z, Li Y, Xie Y, Yao J, Zhu Y et al (2018) Serum-derived extracellular vesicles protect against acute myocardial infarction by regulating miR-21\/PDCD4 signaling pathway. Front Physiol 9:348","journal-title":"Front Physiol"},{"key":"1237_CR105","doi-asserted-by":"publisher","first-page":"2346","DOI":"10.7150\/thno.29945","volume":"9","author":"Y Song","year":"2019","unstructured":"Song Y, Zhang C, Zhang J, Jiao Z, Dong N, Wang G et al (2019) Localized injection of miRNA-21-enriched extracellular vesicles effectively restores cardiac function after myocardial infarction. Theranostics 9:2346\u20132360","journal-title":"Theranostics"},{"key":"1237_CR106","first-page":"3709","volume":"17","author":"C Yang","year":"2019","unstructured":"Yang C, Li B, Liu Y, Xing Y (2019) Ginsenoside Rb1 protects cardiomyocytes from oxygen-glucose deprivation injuries by targeting microRNA-21. Exp Ther Med 17:3709\u20133716","journal-title":"Exp Ther Med"},{"key":"1237_CR107","doi-asserted-by":"publisher","first-page":"12912","DOI":"10.1002\/jcb.28562","volume":"120","author":"L Hao","year":"2019","unstructured":"Hao L, Wang J, Liu N (2019) Long noncoding RNA TALNEC2 regulates myocardial ischemic injury in H9c2 cells by regulating miR-21\/PDCD4-mediated activation of Wnt\/beta-catenin pathway. J Cell Biochem 120:12912\u201312923","journal-title":"J Cell Biochem"},{"key":"1237_CR108","doi-asserted-by":"publisher","first-page":"5529","DOI":"10.1080\/21655979.2021.1965696","volume":"12","author":"H Qi","year":"2021","unstructured":"Qi H, Zhang J, Shang Y, Yuan S, Meng C (2021) Argon inhibits reactive oxygen species oxidative stress via the miR-21-mediated PDCD4\/PTEN pathway to prevent myocardial ischemia\/reperfusion injury. Bioengineered 12:5529\u20135539","journal-title":"Bioengineered"},{"key":"1237_CR109","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2025.107725","volume":"215","author":"DS Xu","year":"2025","unstructured":"Xu DS, Wang Y, Li ZR, Mo PL, Chen MT, Zhao RZ et al (2025) Shenxiong Yixin Decoction polysaccharides exert therapeutic effects against myocardial ischemia-reperfusion injury via intestinal exosomal microRNA-21 regulation. Pharmacol Res 215:107725","journal-title":"Pharmacol Res"},{"key":"1237_CR110","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1007\/s10495-015-1201-6","volume":"21","author":"Z Jia","year":"2016","unstructured":"Jia Z, Wang J, Shi Q, Liu S, Wang W, Tian Y, Lu Q, Chen P, Ma K, Zhou C (2016) SOX6 and PDCD4 enhance cardiomyocyte apoptosis through LPS-induced miR-499 inhibition. Apoptosis 21:174\u2013183","journal-title":"Apoptosis"},{"key":"1237_CR111","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.yjmcc.2021.05.019","volume":"159","author":"C Luo","year":"2021","unstructured":"Luo C, Ling GX, Lei BF, Feng X, Xie XY, Fang C et al (2021) Circular RNA PVT1 silencing prevents ischemia-reperfusion injury in rat by targeting microRNA-125b and microRNA-200a. J Mol Cell Cardiol 159:80\u201390","journal-title":"J Mol Cell Cardiol"},{"key":"1237_CR112","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202400737RR","volume":"38","author":"J Gu","year":"2024","unstructured":"Gu J, Chen X, Luo Z, Li R, Xu Q, Liu M et al (2024) Cardiomyocyte-derived exosomes promote cardiomyocyte proliferation and neonatal heart regeneration. FASEB J 38:e70186","journal-title":"FASEB J"},{"key":"1237_CR113","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2025.111999","volume":"135","author":"Z Zhang","year":"2025","unstructured":"Zhang Z, Yang Z, Ge H, Liu C, Fan R, Yuan C et al (2025) PDCD4 exacerbates myocardial ischemia-reperfusion injury via AKT-mediated apoptosis. Cell Signal 135:111999","journal-title":"Cell Signal"},{"key":"1237_CR114","doi-asserted-by":"publisher","first-page":"1426","DOI":"10.1177\/1535370215573400","volume":"240","author":"Q Su","year":"2015","unstructured":"Su Q, Li L, Wang J, Zhou Y, Liu Y (2015) Mechanism of programmed cell death factor 4\/nuclear factor-\u03baB signaling pathway in porcine coronary micro-embolization-induced cardiac dysfunction. Exp Biol Med (Maywood) 240:1426\u20131433","journal-title":"Exp Biol Med (Maywood)"},{"key":"1237_CR115","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1159\/000363020","volume":"34","author":"Q Su","year":"2014","unstructured":"Su Q, Li L, Zhou Y, Wang J, Liu Y, Ma G (2014) Induction of myocardial PDCD4 in coronary microembolization-related cardiac dysfunction: evidence from a large-animal study. Cell Physiol Biochem 34:533\u2013542","journal-title":"Cell Physiol Biochem"},{"key":"1237_CR116","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.763760","volume":"12","author":"H Zhang","year":"2021","unstructured":"Zhang H et al (2021) Nrf2 promotes inflammation in early myocardial ischemia-reperfusion via recruitment and activation of macrophages. Front Immunol 12:763760","journal-title":"Front Immunol"},{"key":"1237_CR117","doi-asserted-by":"publisher","first-page":"2283","DOI":"10.2147\/CIA.S550861","volume":"20","author":"X Pei","year":"2025","unstructured":"Pei X, Cui F, Chen Y, Yang Z, Xie Z, Wen Y (2025) Serum expression of PDCD4 and ADAM10 in elderly patients with atherosclerotic acute myocardial infarction and their combined predictive value for poor prognosis. Clin Interv Aging 20:2283\u20132292","journal-title":"Clin Interv Aging"},{"key":"1237_CR118","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2019-001081","volume":"8","author":"J Zhang","year":"2020","unstructured":"Zhang J, Zhang M, Yang Z, Huang S, Wu X, Cao L, Wang X, Li Q, Li N, Gao F (2020) PDCD4 deficiency ameliorates left ventricular remodeling and insulin resistance in a rat model of type 2 diabetic cardiomyopathy. BMJ Open Diabetes Res Care 8:e001081","journal-title":"BMJ Open Diabetes Res Care"},{"key":"1237_CR119","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3892\/mmr.2024.13333","volume":"30","author":"L Yu","year":"2024","unstructured":"Yu L, Yang Y, Wang J, Bao Z, Zheng M, Wang X et al (2024) PDCD4 promotes inflammation\/fibrosis by activating the PPAR-gamma\/NF-kappaB pathway in mouse atrial myocytes. Mol Med Rep 30:209","journal-title":"Mol Med Rep"},{"key":"1237_CR120","doi-asserted-by":"publisher","first-page":"1593815","DOI":"10.3389\/fonc.2025.1593815","volume":"15","author":"J Hailati","year":"2025","unstructured":"Hailati J, Liu Z, Zhang L, Wulasihan M (2025) Targeting PDCD4 in cancer and atrial fibrillation: mechanistic insights from integrated multi-omics and single-cell analysis. Front Oncol 15:1593815","journal-title":"Front Oncol"},{"key":"1237_CR121","doi-asserted-by":"publisher","first-page":"L371","DOI":"10.1152\/ajplung.00532.2016","volume":"313","author":"DE Green","year":"2017","unstructured":"Green DE, Murphy TC, Kang BY, Bedi B, Yuan Z, Sadikot RT, Hart CM (2017) Peroxisome proliferator-activated receptor-gamma enhances human pulmonary artery smooth muscle cell apoptosis through microRNA-21 and programmed cell death 4. Am J Physiol Lung Cell Mol Physiol 313:L371\u2013L383","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"1237_CR122","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2023.175968","volume":"956","author":"L Chai","year":"2023","unstructured":"Chai L, Wang Q, Wang Y, Li D, Zhang Q, Chen Y et al (2023) Downregulation of PDCD4 through STAT3\/ATF6\/autophagy mediates MIF-induced PASMCs proliferation\/migration and vascular remodeling. Eur J Pharmacol 956:175968","journal-title":"Eur J Pharmacol"},{"key":"1237_CR123","doi-asserted-by":"publisher","first-page":"2149","DOI":"10.1007\/s11033-020-05314-9","volume":"47","author":"K Zhang","year":"2020","unstructured":"Zhang K, Pan X, Zheng J, Liu Y, Sun L (2020) SIRT1 protects against aortic dissection by regulating AP-1\/decorin signaling-mediated PDCD4 activation. Mol Biol Rep 47:2149\u20132159","journal-title":"Mol Biol Rep"},{"key":"1237_CR124","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.ijcard.2013.09.002","volume":"169","author":"AM Queir\u00f3s","year":"2013","unstructured":"Queir\u00f3s AM, Eschen C, Fliegner D, Kararigas G, Dworatzek E, Westphal C et al (2013) Sex- and estrogen-dependent regulation of a miRNA network in the healthy and hypertrophied heart. Int J Cardiol 169:331\u2013338","journal-title":"Int J Cardiol"},{"key":"1237_CR125","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.mad.2012.09.004","volume":"133","author":"F Olivieri","year":"2012","unstructured":"Olivieri F, Spazzafumo L, Santini G, Lazzarini R, Albertini MC, Rippo MR et al (2012) Age-related differences in the expression of circulating microRNAs: miR-21 as a new circulating marker of inflammaging. Mech Ageing Dev 133:675\u2013685","journal-title":"Mech Ageing Dev"},{"key":"1237_CR126","doi-asserted-by":"publisher","DOI":"10.3389\/fragi.2021.725884","volume":"2","author":"V Dela Justina","year":"2021","unstructured":"Dela Justina V, Miguez JSG, Priviero F, Sullivan JC, Giachini FR, Webb RC (2021) Sex differences in molecular mechanisms of cardiovascular aging. Front Aging 2:725884","journal-title":"Front Aging"}],"container-title":["Journal of Physiology and Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13105-026-01237-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13105-026-01237-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13105-026-01237-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:02:53Z","timestamp":1791072173000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13105-026-01237-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,3]]},"references-count":126,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["1237"],"URL":"https:\/\/doi.org\/10.1007\/s13105-026-01237-4","relation":{},"ISSN":["1138-7548","1877-8755"],"issn-type":[{"value":"1138-7548","type":"print"},{"value":"1877-8755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,3]]},"assertion":[{"value":"5 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 October 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent of participation","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","label":"Consent of publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":4,"name":"Ethics","label":"Clinical trial number","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None.","order":6,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"100"}}