{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T07:06:15Z","timestamp":1771052775046,"version":"3.50.1"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,4,23]],"date-time":"2014-04-23T00:00:00Z","timestamp":1398211200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J. Med. Toxicol."],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1007\/s13181-014-0396-1","type":"journal-article","created":{"date-parts":[[2014,4,22]],"date-time":"2014-04-22T19:33:45Z","timestamp":1398195225000},"page":"102-105","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Massive Naproxen Overdose with Serial Serum Levels"],"prefix":"10.1007","volume":"11","author":[{"given":"Suad A.","family":"Al-Abri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilene B.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatehi","family":"Pedram","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer M.","family":"Colby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kent R.","family":"Olson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,4,23]]},"reference":[{"issue":"1","key":"396_CR1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.2165\/00003495-199040010-00006","volume":"40","author":"PA Todd","year":"1990","unstructured":"Todd PA, Clissold SP (1990) Naproxen. A reappraisal of its pharmacology, and therapeutic use in rheumatic diseases and pain states. Drugs 40(1):91\u2013137","journal-title":"Drugs"},{"issue":"3","key":"396_CR2","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/cpt1974153261","volume":"15","author":"RA Runkel","year":"1974","unstructured":"Runkel RA, Forchielli E, Sevelius H, Chaplin M, Segre E (1974) Nonlinear plasma level response to high doses of naproxen. Clin Pharmacol Ther 15(3):261\u2013266","journal-title":"Clin Pharmacol Ther"},{"issue":"9","key":"396_CR3","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1001\/jama.238.9.938b","volume":"238","author":"EW Fredell","year":"1977","unstructured":"Fredell EW, Strand LJ (1977) Naproxen Overdose JAMA 238(9):938","journal-title":"Naproxen Overdose JAMA"},{"issue":"4","key":"396_CR4","doi-asserted-by":"crossref","first-page":"252","DOI":"10.2165\/00002018-199005040-00003","volume":"5","author":"SC Smolinske","year":"1990","unstructured":"Smolinske SC, Hall AH, Vandenberg SA, Spoerke DG, McBride PV (1990) Toxic effects of nonsteroidal anti-inflammatory drugs in overdose. An overview of recent evidence on clinical effects and dose\u2013response relationships. Drug Saf 5(4):252\u2013274","journal-title":"Drug Saf"},{"issue":"10","key":"396_CR5","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1016\/S0196-0644(89)80939-4","volume":"18","author":"R Martinez","year":"1989","unstructured":"Martinez R, Smith DW, Frankel LR (1989) Severe metabolic acidosis after acute naproxen sodium ingestion. Ann Emerg Med 18(10):1102\u20131104","journal-title":"Ann Emerg Med"},{"issue":"2","key":"396_CR6","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0014-2999(85)90757-5","volume":"111","author":"MC Wallenstein","year":"1985","unstructured":"Wallenstein MC (1985) Differential effects of prostaglandin synthetase inhibitors on EEG in rat. Eur J pharmacol 111(2):201\u2013209","journal-title":"Eur J pharmacol"},{"key":"396_CR7","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.brainres.2007.12.017","volume":"1193","author":"HJ Kim","year":"2008","unstructured":"Kim HJ, Chung JI, Lee SH, Jung YS, Moon CH, Baik EJ (2008) Involvement of endogenous prostaglandin F2alpha on kainic acid-induced seizure activity through FP receptor: the mechanism of proconvulsant effects of COX-2 inhibitors. Brain Res 1193:153\u2013161","journal-title":"Brain Res"},{"issue":"3","key":"396_CR8","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1177\/155005949802900307","volume":"29","author":"E Bortone","year":"1998","unstructured":"Bortone E et al (1998) Triphasic waves associated with acute naproxen overdose: a case report. Clin Electroencephalogr 29(3):142\u2013145","journal-title":"Clin Electroencephalogr"},{"issue":"5","key":"396_CR9","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/S1499-3872(11)60093-3","volume":"10","author":"S Ali","year":"2011","unstructured":"Ali S, Pimentel JD, Ma C (2011) Naproxen-induced liver injury. Hepatobiliary Pancreat Dis Int 10(5):552\u2013556","journal-title":"Hepatobiliary Pancreat Dis Int"},{"issue":"2","key":"396_CR10","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.1365-2796.1992.tb00562.x","volume":"232","author":"H Friis","year":"1992","unstructured":"Friis H, Andreasen PB (1992) Drug-induced hepatic injury: an analysis of 1100 cases reported to the Danish Committee on Adverse Drug Reactions between 1978 and 1987. J Intern Med 232(2):133\u2013138","journal-title":"J Intern Med"},{"issue":"1","key":"396_CR11","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1034\/j.1600-0676.2000.020001093.x","volume":"20","author":"S Laurent","year":"2000","unstructured":"Laurent S, Rahier J, Geubel AP, Lerut J, Horsmans Y (2000) Subfulminant hepatitis requiring liver transplantation following ibuprofen overdose. Liver 20(1):93\u201394","journal-title":"Liver"},{"issue":"6","key":"396_CR12","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1097\/01.mej.0000224428.51623.b2","volume":"13","author":"G Aygencel","year":"2006","unstructured":"Aygencel G, Akbuga B, Keles A (2006) Acute pancreatitis following naproxen intake. Eur J Emerg Med 13(6):372","journal-title":"Eur J Emerg Med"},{"issue":"3","key":"396_CR13","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1097\/00004836-199510000-00022","volume":"21","author":"A Castiella","year":"1995","unstructured":"Castiella A, Lopez P, Bujanda L, Arenas JI (1995) Possible association of acute pancreatitis with naproxen. J Clin Gastroenterol 21(3):258","journal-title":"J Clin Gastroenterol"},{"key":"396_CR14","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/BF00542162","volume":"27","author":"RL Williams","year":"1984","unstructured":"Williams RL, Upton RA, Cello JP et al (1984) Naproxen disposition in patients with alcoholic cirrhosis. Eur J Clin Pharmacol 27:291\u2013296","journal-title":"Eur J Clin Pharmacol"},{"issue":"2","key":"396_CR15","doi-asserted-by":"crossref","first-page":"173","DOI":"10.3109\/15563659509000469","volume":"33","author":"PE Kulling","year":"1995","unstructured":"Kulling PE, Backman EA, Skagius AS, Beckman EA (1995) Renal impairment after acute diclofenac, naproxen, and sulindac overdoses. J Toxicol Clin Toxicol 33(2):173\u2013177","journal-title":"J Toxicol Clin Toxicol"},{"issue":"3","key":"396_CR16","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s13181-010-0076-8","volume":"6","author":"M Levine","year":"2010","unstructured":"Levine M, Khurana A, Ruha AM (2010) Polyuria, acidosis, and coma following massive ibuprofen ingestion. J Med Toxicol 6(3):315\u2013317","journal-title":"J Med Toxicol"},{"key":"396_CR17","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1146\/annurev.pa.33.040193.002251","volume":"33","author":"MD Murray","year":"1993","unstructured":"Murray MD, Brater DC (1993) Renal toxicity of the nonsteroidal anti-inflammatory drugs. Annu Rev Pharmacol Toxicol 33:435\u2013465","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"8","key":"396_CR18","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1007\/s00383-010-2608-3","volume":"26","author":"E Broadis","year":"2010","unstructured":"Broadis E et al (2010) Bilateral ureteric obstruction secondary to renal papillary necrosis. Pediatr Surg Int 26(8):867\u2013869","journal-title":"Pediatr Surg Int"},{"issue":"11","key":"396_CR19","first-page":"1567","volume":"36","author":"SS Weber","year":"1979","unstructured":"Weber SS, Troutman WG, Trujeque L (1979) Effect of hemodialysis on plasma naproxen concentration. Am J Hosp Pharm 36(11):1567\u20131569","journal-title":"Am J Hosp Pharm"},{"issue":"2","key":"396_CR20","first-page":"155","volume":"6","author":"HO Senekjian","year":"1983","unstructured":"Senekjian HO, Lee CS, Kuo TH, Au DS, Krothapalli R (1983) Absorption and disposition of ibuprofen in hemodialyzed uremic patients. Eur J Rheumatol Inflamm 6(2):155\u2013162","journal-title":"Eur J Rheumatol Inflamm"},{"issue":"4","key":"396_CR21","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/(SICI)1099-081X(199605)17:4<355::AID-BDD960>3.0.CO;2-N","volume":"17","author":"SK Niazi","year":"1996","unstructured":"Niazi SK, Alam SM, Ahmad SI (1996) Dose dependent pharmacokinetics of naproxen in man. Biopharm Drug Dispos 17(4):355\u2013361","journal-title":"Biopharm Drug Dispos"},{"issue":"4","key":"396_CR22","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1111\/j.1365-2125.2005.02446.x","volume":"60","author":"K Bowalgaha","year":"2005","unstructured":"Bowalgaha K, Elliot DJ, Mackenzie PI, Knights KM, Swedmark S, Miners JO (2005) S-naproxen and desmethylnaproxen glucuronidation by human liver microsomes and recombinant human UDP-glucuronosyltransferases (UGT): role of UGT2B7 in the elimination of naproxen. Br J Clin Pharmacol 60(4):423\u2013433","journal-title":"Br J Clin Pharmacol"},{"issue":"9","key":"396_CR23","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1177\/106002809502900908","volume":"29","author":"GB Zuckerman","year":"1995","unstructured":"Zuckerman GB, Uy CC (1995) Shock, metabolic acidosis, and coma following ibuprofen overdose in a child. Ann Pharmacother 29(9):869\u2013871","journal-title":"Ann Pharmacother"},{"issue":"2","key":"396_CR24","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1097\/01.PCC.0000257036.26436.42","volume":"8","author":"KE Marciniak","year":"2007","unstructured":"Marciniak KE, Thomas IH, Brogan TV, Roberts JS, Czaja A, Mazor SS (2007) Massive ibuprofen overdose requiring extracorporeal membrane oxygenation for cardiovascular support. Pediatr Crit Care Med 8(2):180\u2013182","journal-title":"Pediatr Crit Care Med"},{"issue":"4","key":"396_CR25","doi-asserted-by":"crossref","first-page":"268","DOI":"10.2165\/00003088-199732040-00002","volume":"32","author":"N Davies","year":"1997","unstructured":"Davies N, Anderson K (1997) Clinical pharmacokinetics of naproxen. Clin Pharmacokinet 32(4):268\u2013293","journal-title":"Clin Pharmacokinet"},{"key":"396_CR26","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/BF03160908","volume":"3","author":"W Holubek","year":"2007","unstructured":"Holubek W, Stolbach A, Nurok S et al (2007) A report of two deaths from massive ibuprofen ingestion. J Med Toxicol 3:52\u201355","journal-title":"J Med Toxicol"}],"container-title":["Journal of Medical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13181-014-0396-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13181-014-0396-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13181-014-0396-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T20:07:19Z","timestamp":1565381239000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s13181-014-0396-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,23]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["396"],"URL":"https:\/\/doi.org\/10.1007\/s13181-014-0396-1","relation":{},"ISSN":["1556-9039","1937-6995"],"issn-type":[{"value":"1556-9039","type":"print"},{"value":"1937-6995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,23]]}}}