{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T18:50:49Z","timestamp":1766515849400,"version":"3.37.3"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T00:00:00Z","timestamp":1553212800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J. Med. Toxicol."],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1007\/s13181-019-00706-1","type":"journal-article","created":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T13:03:36Z","timestamp":1553259816000},"page":"192-197","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Ten Years of Robotripping: Evidence of Tolerance to Dextromethorphan Hydrobromide in a Long-Term User"],"prefix":"10.1007","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4330-1391","authenticated-orcid":false,"given":"Travis D.","family":"Olives","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean P.","family":"Boley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenna M.","family":"LeRoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel J.","family":"Stellpflug","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,3,22]]},"reference":[{"issue":"12","key":"706_CR1","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1097\/01.pec.0000148039.14588.d0","volume":"20","author":"EW Boyer","year":"2004","unstructured":"Boyer EW. Dextromethorphan abuse. Pediatr Emerg Care. 2004;20(12):858\u201363.","journal-title":"Pediatr Emerg Care"},{"issue":"2","key":"706_CR2","doi-asserted-by":"publisher","first-page":"e20","DOI":"10.1331\/JAPhA.2009.08091","volume":"49","author":"F Romanelli","year":"2009","unstructured":"Romanelli F, Smith KM. Dextromethorphan abuse: clinical effects and management. J Am Pharm Assoc. 2009;49(2):e20\u20137.","journal-title":"J Am Pharm Assoc"},{"issue":"1","key":"706_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13011-015-0046-x","volume":"11","author":"DC Spangler","year":"2016","unstructured":"Spangler DC, Loyd CM, Skor EE. Dextromethorphan: a case study on addressing abuse of a safe and effective drug. Subst Abus Treat Prev Policy. 2016;11(1):1\u20137.","journal-title":"Subst Abus Treat Prev Policy"},{"issue":"3","key":"706_CR4","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/j.chc.2016.03.007","volume":"25","author":"M Storck","year":"2016","unstructured":"Storck M, Black L, Liddell M. Inhalant abuse and dextromethorphan. Child Adolesc Psychiatr Clin N Am. 2016;25(3):497\u2013508.","journal-title":"Child Adolesc Psychiatr Clin N Am"},{"issue":"5","key":"706_CR5","doi-asserted-by":"publisher","first-page":"409","DOI":"10.3109\/15563650.2011.585429","volume":"49","author":"MD Wilson","year":"2011","unstructured":"Wilson MD, Ferguson RW, Mazer ME, Litovitz TL. Monitoring trends in dextromethorphan abuse using the National Poison Data System: 2000-2010. Clin Toxicol. 2011;49(5):409\u201315.","journal-title":"Clin Toxicol"},{"issue":"December","key":"706_CR6","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1080\/13556210500352410","volume":"10","author":"SC Miller","year":"2005","unstructured":"Miller SC. Dextromethorphan psychosis, dependence and physical withdrawal. Addict Biol. 2005;10(December):325\u20137.","journal-title":"Addict Biol"},{"issue":"August 7","key":"706_CR7","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/0140-6736(93)91519-R","volume":"342","author":"U Bergman","year":"1993","unstructured":"Bergman U, Myrhed M. Tolerance and withdrawal with zolpidem. Lancet. 1993;342(August 7):373\u20134.","journal-title":"Lancet."},{"issue":"8\u20139 Suppl","key":"706_CR8","doi-asserted-by":"publisher","first-page":"143S","DOI":"10.1002\/j.1552-4604.1981.tb02589.x","volume":"21","author":"R Jones","year":"1981","unstructured":"Jones R, Benowitz N, Herning R. Clinical relevance of cannabis tolerance and dependence. J Clin Pharmacol. 1981;21(8\u20139 Suppl):143S\u201352S.","journal-title":"J Clin Pharmacol"},{"issue":"8","key":"706_CR9","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1093\/clinchem\/36.8.1470","volume":"36","author":"K Emancipator","year":"1990","unstructured":"Emancipator K, Kroll MH. Bromide interference: is less really better? Clin Chem. 1990;36(8):1470\u20133.","journal-title":"Clin Chem"},{"issue":"June","key":"706_CR10","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.cca.2015.07.015","volume":"448","author":"N Finn","year":"2015","unstructured":"Finn N, Wolf J, Louie J, Su B. High concentrations of dextromethorphan result in false-positive in opiate immunoassay test. Clin Chim Acta. 2015;448(June):247.","journal-title":"Clin Chim Acta"},{"issue":"3","key":"706_CR11","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/S0736-4679(99)00234-6","volume":"18","author":"J Schier","year":"2000","unstructured":"Schier J, Diaz JE. Avoid unfavorable consequences: dextromethorphan can bring about a false-positive phencyclidine urine drug screen. J Emerg Med. 2000;18(3):379\u201383.","journal-title":"J Emerg Med"},{"key":"706_CR12","first-page":"459","volume":"22","author":"Y-M Hung","year":"2003","unstructured":"Hung Y-M. Bromide intoxication by the combination of bromide-containing over-the-counter drug and dextromethorphan hydrobromide. Hum Exp Toxicol. 2003;22:459\u201361.","journal-title":"Hum Exp Toxicol"},{"issue":"August","key":"706_CR13","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1111\/ajad.12389","volume":"25","author":"CN Stanciu","year":"2016","unstructured":"Stanciu CN, Penders TM, Rouse EM. Recreational use of dextromethorphan, \u201cRobotripping\u201d\u2014a brief review. Am J Addict. 2016;25(August):374\u20137.","journal-title":"Am J Addict"},{"issue":"2","key":"706_CR14","doi-asserted-by":"publisher","first-page":"e89985","DOI":"10.1371\/journal.pone.0089985","volume":"9","author":"L Nguyen","year":"2014","unstructured":"Nguyen L, Robson MJ, Healy JR, Scandinaro AL, Matsumoto RR. Involvement of sigma-1 receptors in the antidepressant-like effects of dextromethorphan. PLoS One. 2014;9(2):e89985.","journal-title":"PLoS One"},{"issue":"4","key":"706_CR15","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1159\/000168457","volume":"12","author":"Y Ng","year":"1992","unstructured":"Ng Y, Lin W, Chen T, Lin B, Tsai S, Huang T. Spurious hyperchloremia and decreased anion gap in a patient with dextromethorphan hydrobromide. Am J Nephrol. 1992;12(4):268\u201370.","journal-title":"Am J Nephrol"},{"issue":"12","key":"706_CR16","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1177\/0960327107087797","volume":"26","author":"PF Hsieh","year":"2007","unstructured":"Hsieh PF, Tsan YT, Hung DZ, Hsu CL, Lee YC, Chang MH. Bromism caused by mix-formulated analgesic injectables. Hum Exp Toxicol. 2007;26(12):971\u20133.","journal-title":"Hum Exp Toxicol."},{"key":"706_CR17","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1093\/ajcp\/65.1.49","volume":"65","author":"RE Wenk","year":"1976","unstructured":"Wenk RE, Lustagarten JA, Pappas NJ, Levy RI, Jackson R. Serum chloride analysis, bromide detection, and the diagnosis of bromism. Am J Clin Pathol. 1976;65:49\u201357.","journal-title":"Am J Clin Pathol"},{"issue":"7","key":"706_CR18","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1093\/clinchem\/35.7.1538","volume":"35","author":"N Rehak","year":"1989","unstructured":"Rehak N, Andersen T. Evaluation of Gilford chemistry control interference with the chloride method in the Beckman Synchron CX3 system analyzer: cumulative effect of bromide on chloride results. I. Clin Chem. 1989;35(7):1538.","journal-title":"Clin Chem"},{"issue":"8","key":"706_CR19","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1001\/jama.1990.03440080099031","volume":"263","author":"DM Rothenberg","year":"1990","unstructured":"Rothenberg DM, Berns AS, Barkin R, Glantz RH. Bromide intoxication secondary to pyridostigmine bromide therapy. JAMA J Am Med Assoc. 1990;263(8):1121\u20132.","journal-title":"JAMA J Am Med Assoc"},{"issue":"5","key":"706_CR20","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1007\/s10157-010-0303-2","volume":"14","author":"T Ito","year":"2010","unstructured":"Ito T, Ishikawa E, Matsuda Y, Tanoue A, Fujimoto M, Matsuo H, et al. Elevated serum levels of bromine do not always indicate pseudohyperchloremia. Clin Exp Nephrol. 2010;14(5):431\u20135.","journal-title":"Clin Exp Nephrol"},{"issue":"10","key":"706_CR21","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1080\/15563650.2017.1388087","volume":"55","author":"DD Gummin","year":"2017","unstructured":"Gummin DD, Mowry JB, Spyker DA, Brooks DE, Fraser MO, Banner W. 2016 Annual Report of the American Association of Poison Control Centers\u2019 National Poison Data System (NPDS): 34th Annual Report. Clin Toxicol. 2017;55(10):1072\u2013252.","journal-title":"Clin Toxicol"},{"issue":"September","key":"706_CR22","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1136\/bmj.293.6547.597","volume":"293","author":"PM Fleming","year":"1986","unstructured":"Fleming PM. Dependence on dextromethorphan hydrobromide. Br Med J (Clin Res Ed). 1986;293(September):597\u20138.","journal-title":"Br Med J (Clin Res Ed)"},{"issue":"8","key":"706_CR23","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1093\/clinchem\/36.8.1399","volume":"36","author":"G Bowers","year":"1990","unstructured":"Bowers G, Onoroski M. Hyperchloremia and the incidence of bromism in 1990. Clin Chem. 1990;36(8):1399\u2013403.","journal-title":"Clin Chem"}],"container-title":["Journal of Medical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13181-019-00706-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13181-019-00706-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13181-019-00706-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,21]],"date-time":"2020-03-21T00:28:31Z","timestamp":1584750511000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s13181-019-00706-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,22]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["706"],"URL":"https:\/\/doi.org\/10.1007\/s13181-019-00706-1","relation":{},"ISSN":["1556-9039","1937-6995"],"issn-type":[{"type":"print","value":"1556-9039"},{"type":"electronic","value":"1937-6995"}],"subject":[],"published":{"date-parts":[[2019,3,22]]},"assertion":[{"value":"9 December 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 February 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 March 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 March 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Consent for publication of this case was obtained and provided to the journal in accordance with JMT policy.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}