{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:25:38Z","timestamp":1773296738392,"version":"3.50.1"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T00:00:00Z","timestamp":1575244800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T00:00:00Z","timestamp":1575244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"McNeil Consumer Healthcare","award":["IIS-2015-003"],"award-info":[{"award-number":["IIS-2015-003"]}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR000161"],"award-info":[{"award-number":["UL1TR000161"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J. Med. Toxicol."],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1007\/s13181-019-00739-6","type":"journal-article","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T12:32:18Z","timestamp":1575289938000},"page":"177-187","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Circulating microRNA Profiles in Acetaminophen Toxicity"],"prefix":"10.1007","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1798-9006","authenticated-orcid":false,"given":"Stephanie","family":"Carreiro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Marvel-Coen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosalind","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brittany","family":"Chapman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Ambros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,12,2]]},"reference":[{"issue":"6","key":"739_CR1","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.amepre.2011.02.026","volume":"40","author":"DS Budnitz","year":"2011","unstructured":"Budnitz DS, Lovegrove MC, Crosby AE. Emergency department visits for overdoses of acetaminophen-containing products. Am J Prev Med. 2011;40(6):585\u201392. https:\/\/doi.org\/10.1016\/j.amepre.2011.02.026.","journal-title":"Am J Prev Med"},{"issue":"10","key":"739_CR2","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1080\/15563650.2017.1388087","volume":"55","author":"DD Gummin","year":"2017","unstructured":"Gummin DD, Mowry JB, Spyker DA, Brooks DE, Fraser MO, Banner W. 2016 Annual report of the American Association of Poison Control Centers\u2019 National Poison Data System (NPDS): 34th annual report. Clin Toxicol (Philadelphia, Pa). 2017;55(10):1072\u2013252. https:\/\/doi.org\/10.1080\/15563650.2017.1388087.","journal-title":"Clin Toxicol (Philadelphia, Pa)"},{"issue":"6","key":"739_CR3","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1007\/s40291-013-0049-0","volume":"17","author":"DE Amacher","year":"2013","unstructured":"Amacher DE, Schomaker SJ, Aubrecht J. Development of blood biomarkers for drug-induced liver injury: an evaluation of their potential for risk assessment and diagnostics. Mol Diagn Ther. 2013;17(6):343\u201354. https:\/\/doi.org\/10.1007\/s40291-013-0049-0.","journal-title":"Mol Diagn Ther"},{"issue":"5","key":"739_CR4","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1016\/0092-8674(93)90529-Y","volume":"75","author":"RC Lee","year":"1993","unstructured":"Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell. 1993;75(5):843\u201354.","journal-title":"Cell."},{"issue":"4","key":"739_CR5","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1007\/s13181-011-0189-8","volume":"7","author":"J Ward","year":"2011","unstructured":"Ward J, Szabo G, McManus D, Boyer E. Advanced molecular biologic techniques in toxicologic disease. J Med Toxicol. 2011;7(4):288\u201394. https:\/\/doi.org\/10.1007\/s13181-011-0189-8.","journal-title":"J Med Toxicol"},{"issue":"2","key":"739_CR6","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/s40291-013-0065-0","volume":"18","author":"M Osaki","year":"2014","unstructured":"Osaki M, Kosaka N, Okada F, Ochiya T. Circulating microRNAs in drug safety assessment for hepatic and cardiovascular toxicity: the latest biomarker frontier? Mol Diagn Ther. 2014;18(2):121\u20136. https:\/\/doi.org\/10.1007\/s40291-013-0065-0.","journal-title":"Mol Diagn Ther"},{"key":"739_CR7","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.addr.2015.05.001","volume":"87","author":"SM Hammond","year":"2015","unstructured":"Hammond SM. An overview of microRNAs. Adv Drug Deliv Rev. 2015;87:3\u201314. https:\/\/doi.org\/10.1016\/j.addr.2015.05.001.","journal-title":"Adv Drug Deliv Rev"},{"key":"739_CR8","doi-asserted-by":"publisher","first-page":"136","DOI":"10.12688\/f1000research.2-136.v3","volume":"2","author":"P Hydbring","year":"2013","unstructured":"Hydbring P, Badalian-Very G. Clinical applications of microRNAs. F1000Res. 2013;2:136. https:\/\/doi.org\/10.12688\/f1000research.2-136.v3.","journal-title":"F1000Res"},{"issue":"3","key":"739_CR9","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1038\/nrd.2016.246","volume":"16","author":"R Rupaimoole","year":"2017","unstructured":"Rupaimoole R, Slack FJ. MicroRNA therapeutics: towards a new era for the management of cancer and other diseases. Nat Rev Drug Discov. 2017;16(3):203\u201322. https:\/\/doi.org\/10.1038\/nrd.2016.246.","journal-title":"Nat Rev Drug Discov"},{"issue":"5","key":"739_CR10","doi-asserted-by":"publisher","first-page":"1946","DOI":"10.1002\/hep.25873","volume":"56","author":"S Bala","year":"2012","unstructured":"Bala S, Petrasek J, Mundkur S, Catalano D, Levin I, Ward J, et al. Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic, drug-induced, and inflammatory liver diseases. Hepatology (Baltimore, Md). 2012;56(5):1946\u201357. https:\/\/doi.org\/10.1002\/hep.25873.","journal-title":"Hepatology (Baltimore, Md)"},{"issue":"22","key":"739_CR11","doi-asserted-by":"publisher","first-page":"2798","DOI":"10.3748\/wjg.v18.i22.2798","volume":"18","author":"J Ward","year":"2012","unstructured":"Ward J, Bala S, Petrasek J, Szabo G. Plasma microRNA profiles distinguish lethal injury in acetaminophen toxicity: a research study. World J Gastroenterol. 2012;18(22):2798\u2013804. https:\/\/doi.org\/10.3748\/wjg.v18.i22.2798.","journal-title":"World J Gastroenterol"},{"issue":"5","key":"739_CR12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0037395","volume":"7","author":"YW Su","year":"2012","unstructured":"Su YW, Chen X, Jiang ZZ, Wang T, Wang C, Zhang Y, et al. A panel of serum microRNAs as specific biomarkers for diagnosis of compound- and herb-induced liver injury in rats. PLoS One. 2012;7(5):e37395. https:\/\/doi.org\/10.1371\/journal.pone.0037395.","journal-title":"PLoS One"},{"issue":"2","key":"739_CR13","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1093\/toxsci\/kfr321","volume":"125","author":"X Yang","year":"2012","unstructured":"Yang X, Greenhaw J, Shi Q, Su Z, Qian F, Davis K, et al. Identification of urinary microRNA profiles in rats that may diagnose hepatotoxicity. Toxicol Sci. 2012;125(2):335\u201344. https:\/\/doi.org\/10.1093\/toxsci\/kfr321.","journal-title":"Toxicol Sci"},{"issue":"4","key":"739_CR14","doi-asserted-by":"publisher","first-page":"401","DOI":"10.2131\/jts.32.401","volume":"32","author":"T Fukushima","year":"2007","unstructured":"Fukushima T, Hamada Y, Yamada H, Horii I. Changes of micro-RNA expression in rat liver treated by acetaminophen or carbon tetrachloride--regulating role of micro-RNA for RNA expression. J Toxicol Sci. 2007;32(4):401\u20139.","journal-title":"J Toxicol Sci"},{"issue":"2","key":"739_CR15","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1007\/s00204-017-2090-y","volume":"92","author":"D Yu","year":"2018","unstructured":"Yu D, Wu L, Gill P, Tolleson WH, Chen S, Sun J, et al. Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018;92(2):845\u201358. https:\/\/doi.org\/10.1007\/s00204-017-2090-y.","journal-title":"Arch Toxicol"},{"issue":"11","key":"739_CR16","doi-asserted-by":"publisher","first-page":"4402","DOI":"10.1073\/pnas.0813371106","volume":"106","author":"K Wang","year":"2009","unstructured":"Wang K, Zhang S, Marzolf B, Troisch P, Brightman A, Hu Z, et al. Circulating microRNAs, potential biomarkers for drug-induced liver injury. Proc Natl Acad Sci U S A. 2009;106(11):4402\u20137. https:\/\/doi.org\/10.1073\/pnas.0813371106.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"739_CR17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0177928","volume":"12","author":"J Krauskopf","year":"2017","unstructured":"Krauskopf J, de Kok TM, Schomaker SJ, Gosink M, Burt DA, Chandler P, et al. Serum microRNA signatures as \u201cliquid biopsies\u201d for interrogating hepatotoxic mechanisms and liver pathogenesis in human. PLoS One. 2017;12(5):e0177928. https:\/\/doi.org\/10.1371\/journal.pone.0177928.","journal-title":"PLoS One"},{"issue":"10","key":"739_CR18","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1080\/15563650.2018.1454596","volume":"56","author":"A Wong","year":"2018","unstructured":"Wong A, Cheung B, Nejad C, Gantier M, Graudins A. Hepatotoxicity after paracetamol overdose in a patient with cystic fibrosis despite early acetylcysteine and utility of microRNA to predict hepatotoxicity. Clin Toxicol (Philadelphia, PA). 2018;56(10):904\u20136. https:\/\/doi.org\/10.1080\/15563650.2018.1454596.","journal-title":"Clin Toxicol (Philadelphia, PA)"},{"key":"739_CR19","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1177\/0960327119833740","volume":"38","author":"A Wong","year":"2019","unstructured":"Wong A, Nejad C, Gantier M, Choy KW, Doery J, Graudins A. MicroRNA from a 12-h versus 20-h acetylcysteine infusion for paracetamol overdose. Hum Exp Toxicol. 2019;38:646\u201354. https:\/\/doi.org\/10.1177\/0960327119833740.","journal-title":"Hum Exp Toxicol"},{"issue":"33","key":"739_CR20","doi-asserted-by":"publisher","first-page":"12169","DOI":"10.1073\/pnas.1412608111","volume":"111","author":"J Ward","year":"2014","unstructured":"Ward J, Kanchagar C, Veksler-Lublinsky I, Lee RC, McGill MR, Jaeschke H, et al. Circulating microRNA profiles in human patients with acetaminophen hepatotoxicity or ischemic hepatitis. Proc Natl Acad Sci U S A. 2014;111(33):12169\u201374. https:\/\/doi.org\/10.1073\/pnas.1412608111.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"739_CR21","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.1002\/hep.24538","volume":"54","author":"PJ Starkey Lewis","year":"2011","unstructured":"Starkey Lewis PJ, Dear J, Platt V, Simpson KJ, Craig DG, Antoine DJ, et al. Circulating microRNAs as potential markers of human drug-induced liver injury. Hepatology (Baltimore, Md). 2011;54(5):1767\u201376. https:\/\/doi.org\/10.1002\/hep.24538.","journal-title":"Hepatology (Baltimore, Md)"},{"issue":"2","key":"739_CR22","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1002\/hep.26294","volume":"58","author":"DJ Antoine","year":"2013","unstructured":"Antoine DJ, Dear JW, Lewis PS, Platt V, Coyle J, Masson M, et al. Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital. Hepatology (Baltimore, Md). 2013;58(2):777\u201387. https:\/\/doi.org\/10.1002\/hep.26294.","journal-title":"Hepatology (Baltimore, Md)"},{"issue":"11","key":"739_CR23","doi-asserted-by":"publisher","first-page":"1732","DOI":"10.1248\/bpb.b18-00504","volume":"41","author":"C Munakata","year":"2018","unstructured":"Munakata C, Fuchigami Y, Hiroishi S, Haraguchi A, Hagimori M, Enomoto H, et al. Evaluation of miR-122 to predict high dose acetaminophen-induced liver injury in mice: the combination uses of 5-fluorouracil. Biol Pharm Bull. 2018;41(11):1732\u20135. https:\/\/doi.org\/10.1248\/bpb.b18-00504.","journal-title":"Biol Pharm Bull"},{"issue":"2","key":"739_CR24","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","volume":"42","author":"PA Harris","year":"2009","unstructured":"Harris PA, Taylor R, Thielke R, Payne J, Gonzalez N, Conde JG. Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform. 2009;42(2):377\u201381. https:\/\/doi.org\/10.1016\/j.jbi.2008.08.010.","journal-title":"J Biomed Inform"},{"issue":"6","key":"739_CR25","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1093\/bioinformatics\/btl664","volume":"23","author":"P Liu","year":"2007","unstructured":"Liu P, Hwang JTG. Quick calculation for sample size while controlling false discovery rate with application to microarray analysis. Bioinformatics (Oxford, England). 2007;23(6):739\u201346. https:\/\/doi.org\/10.1093\/bioinformatics\/btl664.","journal-title":"Bioinformatics (Oxford, England)"},{"issue":"20","key":"739_CR26","doi-asserted-by":"publisher","first-page":"3940","DOI":"10.1093\/bioinformatics\/bti623","volume":"21","author":"T Sing","year":"2005","unstructured":"Sing T, Sander O, Beerenwinkel N, Lengauer T. ROCR: visualizing classifier performance in R. Bioinformatics (Oxford, England). 2005;21(20):3940\u20131. https:\/\/doi.org\/10.1093\/bioinformatics\/bti623.","journal-title":"Bioinformatics (Oxford, England)"},{"key":"739_CR27","doi-asserted-by":"publisher","DOI":"10.1038\/srep15501","volume":"5","author":"ADB Vliegenthart","year":"2015","unstructured":"Vliegenthart ADB, Shaffer JM, Clarke JI, Peeters LEJ, Caporali A, Bateman DN, et al. Comprehensive microRNA profiling in acetaminophen toxicity identifies novel circulating biomarkers for human liver and kidney injury. Sci Rep. 2015;5:15501. https:\/\/doi.org\/10.1038\/srep15501\nhttps:\/\/www.nature.com\/articles\/srep15501#supplementary-information.","journal-title":"Sci Rep"}],"container-title":["Journal of Medical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13181-019-00739-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13181-019-00739-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13181-019-00739-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,30]],"date-time":"2020-11-30T19:47:17Z","timestamp":1606765637000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s13181-019-00739-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,2]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["739"],"URL":"https:\/\/doi.org\/10.1007\/s13181-019-00739-6","relation":{},"ISSN":["1556-9039","1937-6995"],"issn-type":[{"value":"1556-9039","type":"print"},{"value":"1937-6995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,2]]},"assertion":[{"value":"5 June 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 September 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 September 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 December 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This protocol was reviewed and approved by the University of Massachusetts Medical School Institutional Review Board.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of Interest"}}]}}