{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T17:02:04Z","timestamp":1740157324779,"version":"3.37.3"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100014046","name":"Air Force Surgeon General","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014046","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J. Med. Toxicol."],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1007\/s13181-020-00767-7","type":"journal-article","created":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T21:02:25Z","timestamp":1585774945000},"page":"388-397","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy of Intravenous Hydroxocobalamin for Treatment of Sodium Methanethiolate Exposure in a Swine Model (Sus scrofa) of Severe Methanethiol Toxicity"],"prefix":"10.1007","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8341-4182","authenticated-orcid":false,"given":"Joseph K.","family":"Maddry","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. Madelaine","family":"Paredes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Rebeles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glen","family":"Olson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Castaneda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaysie","family":"Canellis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick C.","family":"Ng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vikhyat S.","family":"Bebarta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,4,1]]},"reference":[{"key":"767_CR1","unstructured":"\u201cToxic Substances Portal - Methyl Mercaptan.\u201d Centers for Disease Control and Prevention. Agency for Toxic Substancecs & Disease Registry (ATSDR). Available from: www.atsdr.cdc.gov\/MMG\/MMG.asp?id=221&tid=40. Accessed 24 Jan 2020."},{"key":"767_CR2","unstructured":"National Center for Biotechnology Information. PubChem Database. Methanethiol, CID=878. Available from: https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Methanethiol. Accessed 29 Oct 2020."},{"key":"767_CR3","unstructured":"Four DuPont Workers Die In Texas Chemical Leak. National Public Radio. 11-1-2014. 4-6-2014. Available from: https:\/\/www.npr.org\/2014\/11\/16\/364428076\/4-dupont-workers-die-in-texas-chemical-leak. Accessed 30 Oct 2020."},{"key":"767_CR4","unstructured":"Methyl Mercaptan Occupational Safety and Health Administration. 2015. 4-6-2015. Available from: https:\/\/www.osha.gov\/dts\/sltc\/methods\/organic\/org026\/org026.html. Accessed 30 Oct 2020."},{"key":"767_CR5","unstructured":"Acute exposure guideline levels for selected airborne chemicals: Volume 15. Washington (DC) 2013. Available from: https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24830067. Accessed 24 Jan 2020."},{"key":"767_CR6","unstructured":"Toxic Industrial Chemicals (TICs) Guide. Occupational Safety and Health Administration . 2015. 4-6-2015. Available from: https:\/\/www.osha.gov\/SLTC\/emergencypreparedness\/guides\/chemical.html. Accessed 29 Oct 2020."},{"key":"767_CR7","doi-asserted-by":"crossref","unstructured":"Benchoam D, Cuevasanta E, Moller MN, Alvarez B. Hydrogen sulfide and persulfides oxidation by biologically relevant oxidizing species. Antioxidants (Basel). 2019;8(2) Available from: https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30813248. Accessed 27 Jan 2020.","DOI":"10.3390\/antiox8020048"},{"key":"767_CR8","doi-asserted-by":"crossref","unstructured":"Roman P, Bijmans MF, Janssen AJ. Influence of methanethiol on biological sulphide oxidation in gas treatment system. Environ Technol. 2016;37(13):1693\u2013703 Available from: https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26652658. Accessed 27 Jan 2020.","DOI":"10.1080\/09593330.2015.1128001"},{"key":"767_CR9","unstructured":"Information. NCfB. \u201cMethanethiol.\u201d U.S. National Library of Medicine. PubChem Compound Database. Methanethiol, CID=878. Available from: https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Methanethiol. Accessed 24 Jan 2020."},{"key":"767_CR10","unstructured":"Ng PC, Hendry-Hofer TB, Witeof AE, Brenner M, Mahon SB, Boss GR, et al. Hydrogen sulfide toxicity: mechanism of action, clinical presentation, and countermeasure development. J Med Toxicol. 2019. Available from: https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31062177. Accessed 29 Oct 2019."},{"key":"767_CR11","doi-asserted-by":"crossref","unstructured":"Bebarta VS, Garrett N, Brenner M, Mahon SB, Maddry JK, Boudreau S, et al. Efficacy of intravenous cobinamide versus hydroxocobalamin or saline for treatment of severe hydrogen sulfide toxicity in a swine (Sus scrofa) model. Acad Emerg Med. 2017;24(9):1088\u201398 Available from: https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28472554. Accessed 30 Oct 2019.","DOI":"10.1111\/acem.13213"},{"key":"767_CR12","doi-asserted-by":"crossref","unstructured":"Jiang J, Chan A, Ali S, Saha A, Haushalter KJ, Lam WL, et al. Hydrogen sulfide--mechanisms of toxicity and development of an antidote. Sci Rep. 2016;6:20831 Available from: https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26877209. Accessed 29 Oct 2019.","DOI":"10.1038\/srep20831"},{"key":"767_CR13","doi-asserted-by":"crossref","unstructured":"Borron SW, Baud FJ, Megarbane B, Bismuth C. Hydroxocobalamin for severe acute cyanide poisoning by ingestion or inhalation. Am J Emerg Med. 2007;25(5):551\u20138 Available from: https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17543660. Accessed 28 Oct 2019.","DOI":"10.1016\/j.ajem.2006.10.010"},{"key":"767_CR14","doi-asserted-by":"crossref","unstructured":"Hendry-Hofer TB, Ng PC, Witeof AE, Mahon SB, Brenner M, Boss GR, et al. A review on ingested cyanide: risks, clinical presentation, diagnostics, and treatment challenges. J Med Toxicol. 2019;15(2):128\u201333 Available from: https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30539383. Accessed 1 Nov 2019.","DOI":"10.1007\/s13181-018-0688-y"},{"key":"767_CR15","doi-asserted-by":"crossref","unstructured":"Shepherd G, Velez LI. Role of hydroxocobalamin in acute cyanide poisoning. Ann Pharmacother. 2008;42(5):661\u20139 Available from: https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18397973. Accessed 28 Oct 2019.","DOI":"10.1345\/aph.1K559"},{"key":"767_CR16","doi-asserted-by":"crossref","unstructured":"Jones KR. Hydroxocobalamin (Cyanokit): a new antidote for cyanide toxicity. Adv Emerg Nurs J. 2008;30(2):112\u201321 Available from: https:\/\/insights.ovid.com\/article\/01261775-200804000-00004. Accessed 30 Oct 2019.","DOI":"10.1097\/01.TME.0000319922.66978.96"},{"key":"767_CR17","unstructured":"Purvis MV, Rooks H, Young Lee J, Longerich S, Kahn SA. Prehospital hydroxocobalamin for inhalation injury and cyanide toxicity in the United States - analysis of a database and survey of ems providers. Ann Burns Fire Disasters. 2017;30(2):126\u20138 Available from: https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29021725. Accessed 28 Oct 2019."},{"key":"767_CR18","unstructured":"Hazardous Substances Data Bank (HSDB). U.S. National Library of Medicine, National Institutes of Health. Available from: https:\/\/toxnet.nlm.nih.gov\/cgi-bin\/sis\/search2\/r?dbs+hsdb:@term+@rn+@rel+74-93-1. Accessed 29 Oct 2019."},{"key":"767_CR19","unstructured":"Committee on Acute Exposure Guideline Levels. \u201c2. Methyl Mercaptan Acute Exposure Guideline Levels.\u201d Acute exposure guideline levels for selected airborne chemicals: Volume 15., U.S. National Library of Medicine, 26 Sept. 2013. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK201324\/. Accessed 30 Oct 2019."},{"key":"767_CR20","doi-asserted-by":"crossref","unstructured":"Finkelstein A, Benevenga NJ. The effect of methanethiol and methionine toxicity on the activities of cytochrome c oxidase and enzymes involved in protection from peroxidative damage. J Nutr. 1986;116(2):204\u201315 Available from: https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/3003292. Accessed 28 Oct 2019.","DOI":"10.1093\/jn\/116.2.204"},{"key":"767_CR21","doi-asserted-by":"crossref","unstructured":"Bebarta VS, Tanen DA, Boudreau S, Castaneda M, Zarzabal LA, Vargas T, et al. Intravenous cobinamide versus hydroxocobalamin for acute treatment of severe cyanide poisoning in a swine (Sus scrofa) model. Ann Emerg Med. 2014;64(6):612\u20139 Available from: https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24746273. Accessed 28 Oct 2019.","DOI":"10.1016\/j.annemergmed.2014.02.009"},{"key":"767_CR22","doi-asserted-by":"crossref","unstructured":"Bebarta VS, Garrett N, Boudreau S, Castaneda M. A prospective, randomized trial of intravenous hydroxocobalamin versus whole blood transfusion compared to no treatment for class III hemorrhagic shock resuscitation in a prehospital swine model. Acad Emerg Med. 2015;22(3):321\u201330 Available from: https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25731610. Accessed 30 Oct 2019.","DOI":"10.1111\/acem.12605"},{"key":"767_CR23","doi-asserted-by":"crossref","unstructured":"Bebarta VS, Garrett N, Boudreau S, Castaneda M. Intravenous hydroxocobalamin versus hextend versus control for class III hemorrhage resuscitation in a prehospital swine model. Mil Med. 2018;183(11-12):e721\u2013e9 Available from: https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30500921. Accessed 30 Oct 2019.","DOI":"10.1093\/milmed\/usy173"},{"key":"767_CR24","doi-asserted-by":"crossref","unstructured":"Bebarta VS, Pitotti RL, Dixon PS, Valtier S, Esquivel L, Bush A, et al. Hydroxocobalamin and epinephrine both improve survival in a swine model of cyanide-induced cardiac arrest. Ann Emerg Med. 2012;60(4):415\u201322 Available from: https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22424656. Accessed 30 Oct 2019.","DOI":"10.1016\/j.annemergmed.2012.02.002"},{"issue":"13","key":"767_CR25","doi-asserted-by":"publisher","first-page":"2153","DOI":"10.1001\/jama.1970.03170130049013","volume":"211","author":"WT Shults","year":"1970","unstructured":"Shults WT, Fountain EN, Lynch EC. Methanethiol poisoning: irreversible coma and hemolytic anemia following inhalation. JAMA. 1970;211(13):2153\u20134. Available from:. https:\/\/doi.org\/10.1001\/jama.1970.03170130049013.","journal-title":"JAMA"},{"key":"767_CR26","doi-asserted-by":"crossref","unstructured":"Jiwani AZ, Bebarta VS, Cancio LC. Acquired methemoglobinemia after hydroxocobalamin administration in a patient with burns and inhalation injury. Clin Toxicol (Phila). 2018;56(5):370\u20132 Available from: https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28969436. Accessed 30 Oct 2019.","DOI":"10.1080\/15563650.2017.1377838"}],"container-title":["Journal of Medical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13181-020-00767-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13181-020-00767-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13181-020-00767-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T23:58:51Z","timestamp":1617235131000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s13181-020-00767-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,1]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["767"],"URL":"https:\/\/doi.org\/10.1007\/s13181-020-00767-7","relation":{},"ISSN":["1556-9039","1937-6995"],"issn-type":[{"type":"print","value":"1556-9039"},{"type":"electronic","value":"1937-6995"}],"subject":[],"published":{"date-parts":[[2020,4,1]]},"assertion":[{"value":"22 November 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 February 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 February 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The protocol was approved by the 59th Medical Wing (MDW) Institutional Animal Care and Use Committee (IACUC). The study was conducted in accordance with the regulations and guidelines of the Animal Welfare Act, the National Institutes of Health Guide for the Care and Use of Laboratory Animals, and the American Association for the Accreditation of Laboratory Animal Care.\u00a0","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The views expressed are those of the authors and do not reflect the official views or policy of the Department of Defense or its Components.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclaimer"}},{"value":"None.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of Interest"}}]}}