{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T22:44:18Z","timestamp":1779317058310,"version":"3.51.4"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T00:00:00Z","timestamp":1638144000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T00:00:00Z","timestamp":1638144000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100000925","name":"national health and medical research council","doi-asserted-by":"publisher","award":["Senior Research Fellowship ID1061041."],"award-info":[{"award-number":["Senior Research Fellowship ID1061041."]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J. Med. Toxicol."],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1007\/s13181-021-00865-0","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T19:44:26Z","timestamp":1638301466000},"page":"30-37","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Activated Charcoal and Bicarbonate for Aspirin Toxicity: a Retrospective Series"],"prefix":"10.1007","volume":"18","author":[{"given":"K. Z.","family":"Isoardi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Henry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Harris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. K.","family":"Isbister","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,11,29]]},"reference":[{"issue":"1","key":"865_CR1","doi-asserted-by":"publisher","first-page":"20","DOI":"10.2165\/00002512-199202010-00004","volume":"2","author":"C Durnas","year":"1992","unstructured":"Durnas C, Cusack BJ. Salicylate intoxication in the elderly. Drugs Aging. 1992;2(1):20\u201334.","journal-title":"Drugs Aging"},{"issue":"26","key":"865_CR2","doi-asserted-by":"publisher","first-page":"2544","DOI":"10.1056\/NEJMra2010852","volume":"382","author":"BF Palmer","year":"2020","unstructured":"Palmer BF, Clegg DJ. Salicylate toxicity. N Engl J Med. 2020;382(26):2544\u201355.","journal-title":"N Engl J Med"},{"key":"865_CR3","doi-asserted-by":"crossref","unstructured":"Done AK. Salicylate intoxication. Significance of measurements of salicylate in blood in cases of acute ingestion. Pediatrics. 1960;26:800\u20137.","DOI":"10.1542\/peds.26.5.800"},{"issue":"5656","key":"865_CR4","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1136\/bmj.2.5656.547","volume":"2","author":"AT Proudfoot","year":"1969","unstructured":"Proudfoot AT, Brown SS. Acidaemia and salicylate poisoning in adults. Br Med J. 1969;2(5656):547\u201350.","journal-title":"Br Med J"},{"key":"865_CR5","doi-asserted-by":"crossref","unstructured":"Done AK. Aspirin overdosage: incidence, diagnosis, and management. Pediatrics. 1978;62(5 Pt 2 Suppl):890\u20137.","DOI":"10.1542\/peds.62.5S.890"},{"issue":"8","key":"865_CR6","doi-asserted-by":"publisher","first-page":"438","DOI":"10.5694\/mja14.01116","volume":"202","author":"NA Buckley","year":"2015","unstructured":"Buckley NA, Whyte IM, Dawson AH, Isbister GK. A prospective cohort study of trends in self-poisoning, Newcastle, Australia, 1987\u20132012: plus \u00e7a change, plus c\u2019est la m\u00eame chose. Med J Aust. 2015;202(8):438\u201342.","journal-title":"Med J Aust"},{"key":"865_CR7","doi-asserted-by":"crossref","unstructured":"Temple AR. Acute and chronic effects of aspirin toxicity and their treatment. Arch Intern Med. 1981;141(3 Spec No):364\u20139.","DOI":"10.1001\/archinte.141.3.364"},{"issue":"4","key":"865_CR8","doi-asserted-by":"publisher","first-page":"292","DOI":"10.2165\/00002018-199207040-00005","volume":"7","author":"L Notarianni","year":"1992","unstructured":"Notarianni L. A reassessment of the treatment of salicylate poisoning. Drug Saf. 1992;7(4):292\u2013303.","journal-title":"Drug Saf"},{"issue":"3","key":"865_CR9","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1002\/cpt1972133317","volume":"13","author":"G Levy","year":"1972","unstructured":"Levy G, Tsuchiya T. Effect of activated charcoal on aspirin absorption in man. Part I Clin Pharmacol Ther. 1972;13(3):317\u201322.","journal-title":"Part I Clin Pharmacol Ther"},{"issue":"3","key":"865_CR10","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1007\/BF00609985","volume":"13","author":"PJ Neuvonen","year":"1978","unstructured":"Neuvonen PJ, Elfving SM, Elonen E. Reduction of absorption of digoxin, phenytoin and aspirin by activated charcoal in man. Eur J Clin Pharmacol. 1978;13(3):213\u20138.","journal-title":"Eur J Clin Pharmacol"},{"issue":"3","key":"865_CR11","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1038\/clpt.1989.137","volume":"46","author":"LA Kirshenbaum","year":"1989","unstructured":"Kirshenbaum LA, Mathews SC, Sitar DS, Tenenbein M. Whole-bowel irrigation versus activated charcoal in sorbitol for the ingestion of modified-release pharmaceuticals. Clin Pharmacol Ther. 1989;46(3):264\u201371.","journal-title":"Clin Pharmacol Ther"},{"issue":"10","key":"865_CR12","first-page":"550","volume":"32","author":"TB Vree","year":"1994","unstructured":"Vree TB, Van Ewijk-BenekenKolmer EW, Verwey-Van Wissen CP, Hekster YA. Effect of urinary pH on the pharmacokinetics of salicylic acid, with its glycine and glucuronide conjugates in human. Int J Clin Pharmacol Ther. 1994;32(10):550\u20138.","journal-title":"Int J Clin Pharmacol Ther"},{"issue":"7","key":"865_CR13","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1080\/15563650.2019.1674322","volume":"58","author":"MA Downes","year":"2020","unstructured":"Downes MA, Page CB, Berling I, Whyte IM, Isbister GK. Use of a tablet-based application for clinical handover and data collection. Clin Toxicol (Phila). 2020;58(7):692\u20137.","journal-title":"Clin Toxicol (Phila)"},{"issue":"Suppl","key":"865_CR14","first-page":"1","volume":"2","author":"KDIGO Clinical Practie Guideline for Acute Kidney Injury","year":"2012","unstructured":"KDIGO Clinical Practie Guideline for Acute Kidney Injury. Kidney Int. 2012;2(Suppl):1\u2013138.","journal-title":"Kidney Int"},{"issue":"12","key":"865_CR15","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.1080\/15563650.2020.1834219","volume":"58","author":"DD Gummin","year":"2020","unstructured":"Gummin DD, Mowry JB, Beuhler MC, Spyker DA, Brooks DE, Dibert KW, et al. 2019 Annual Report of the American Association of Poison Control Centers\u2019 National Poison Data System (NPDS): 37th Annual Report. Clin Toxicol (Phila). 2020;58(12):1360\u2013541.","journal-title":"Clin Toxicol (Phila)"},{"issue":"5","key":"865_CR16","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1053\/ajem.2000.9261","volume":"18","author":"TL Litovitz","year":"2000","unstructured":"Litovitz TL, Klein-Schwartz W, White S, Cobaugh DJ, Youniss J, Drab A, et al. 1999 annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System. Am J Emerg Med. 2000;18(5):517\u201374.","journal-title":"Am J Emerg Med"},{"key":"865_CR17","unstructured":"Group TaTE. Therapeutic guidelines: toxicology and toxinology. Melbourne: Therapeutic Guidelines Limited; 2020."},{"issue":"6352","key":"865_CR18","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1136\/bmj.285.6352.1383","volume":"285","author":"LF Prescott","year":"1982","unstructured":"Prescott LF, Balali-Mood M, Critchley JA, Johnstone AF, Proudfoot AT. Diuresis or urinary alkalinisation for salicylate poisoning? Br Med J (Clin Res Ed). 1982;285(6352):1383\u20136.","journal-title":"Br Med J (Clin Res Ed)"},{"issue":"3\u20134","key":"865_CR19","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1007\/s10928-005-0022-6","volume":"32","author":"LE Friberg","year":"2005","unstructured":"Friberg LE, Isbister GK, Hackett LP, Duffull SB. The population pharmacokinetics of citalopram after deliberate self-poisoning: a Bayesian approach. J Pharmacokinet Pharmacodyn. 2005;32(3\u20134):571\u2013605.","journal-title":"J Pharmacokinet Pharmacodyn"}],"container-title":["Journal of Medical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13181-021-00865-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13181-021-00865-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13181-021-00865-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T16:33:12Z","timestamp":1642091592000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13181-021-00865-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,29]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["865"],"URL":"https:\/\/doi.org\/10.1007\/s13181-021-00865-0","relation":{},"ISSN":["1556-9039","1937-6995"],"issn-type":[{"value":"1556-9039","type":"print"},{"value":"1937-6995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,29]]},"assertion":[{"value":"25 July 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 October 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 November 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 November 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}