{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T01:23:46Z","timestamp":1782523426784,"version":"3.54.5"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T00:00:00Z","timestamp":1662422400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T00:00:00Z","timestamp":1662422400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J. Med. Toxicol."],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1007\/s13181-022-00907-1","type":"journal-article","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T15:22:20Z","timestamp":1662477740000},"page":"334-339","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Warfarin Overdose in an Adolescent Not Dependent on Anticoagulation: Reversal Strategy and Kinetics"],"prefix":"10.1007","volume":"18","author":[{"given":"C. James","family":"Watson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Simpson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James D.","family":"Whitledge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Al","family":"Patterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele M.","family":"Burns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,9,6]]},"reference":[{"issue":"2","key":"907_CR1","doi-asserted-by":"publisher","first-page":"e152S","DOI":"10.1378\/chest.11-2295","volume":"141","author":"A Holbrook","year":"2012","unstructured":"Holbrook A, Schulman S, Witt DM, et al. Evidence-based management of anticoagulant therapy. Chest. 2012;141(2):e152S-e184S. https:\/\/doi.org\/10.1378\/chest.11-2295.","journal-title":"Chest"},{"issue":"3","key":"907_CR2","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1111\/j.1365-2141.2011.08753.x","volume":"154","author":"D Keeling","year":"2011","unstructured":"Keeling D, Baglin T, Tait C, Watson H, Perry D, Baglin C, Kitchen S, Makris M. British Committee for standards in haematology. Guidelines on oral anticoagulation with warfarin - fourth edition. Br J Haematol. 2011;154(3):311\u201324. https:\/\/doi.org\/10.1111\/j.1365-2141.2011.08753.x.","journal-title":"Br J Haematol."},{"issue":"4","key":"907_CR3","doi-asserted-by":"publisher","first-page":"198","DOI":"10.5694\/mja12.10614","volume":"198","author":"HA Tran","year":"2013","unstructured":"Tran HA, Chunilal SD, Harper PL, Tran H, Wood EM, Gallus AS. Australasian Society of Thrombosis and Haemostasis (ASTH). An update of consensus guidelines for warfarin reversal. Med J Aust. 2013;198(4):198\u20139. https:\/\/doi.org\/10.5694\/mja12.10614.","journal-title":"Med J Aust."},{"key":"907_CR4","unstructured":"Lasoff DR. Warfarin and Superwarfarins. In: Olson KR, Smollin CG, Anderson IB et al., eds. Poisoning & Drug Overdose. 8th ed. McGraw-Hill Education; 2022:458\u2013460."},{"issue":"3","key":"907_CR5","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1111\/bcp.12736","volume":"81","author":"DN Bateman","year":"2016","unstructured":"Bateman DN, Page CB. Antidotes to coumarins, isoniazid, methotrexate and thyroxine, toxins that work via metabolic processes. Br J Clin Pharmacol. 2016;81(3):437\u201345. https:\/\/doi.org\/10.1111\/bcp.12736.","journal-title":"Br J Clin Pharmacol"},{"key":"907_CR6","unstructured":"Coumadin(R) (Warfarin Sodium) [Package Insert]. Bristol-Myers Squibb Company; 2011."},{"issue":"1","key":"907_CR7","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1055\/s-0038-1654292","volume":"25","author":"RA O\u2019Reilly","year":"1971","unstructured":"O\u2019Reilly RA, Welling PG, Wagner JG. Pharmacokinetics of warfarin following intravenous administration to man. Thromb Haemost. 1971;25(1):178\u201386.","journal-title":"Thromb Haemost"},{"issue":"12","key":"907_CR8","doi-asserted-by":"publisher","first-page":"642","DOI":"10.5694\/j.1326-5377.1985.tb113560.x","volume":"142","author":"LP Hackett","year":"1985","unstructured":"Hackett LP, Ilett KF, Chester A. Plasma warfarin concentrations after a massive overdose. Med J Aust. 1985;142(12):642\u20133. https:\/\/doi.org\/10.5694\/j.1326-5377.1985.tb113560.x.","journal-title":"Med J Aust"},{"issue":"6","key":"907_CR9","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1097\/00007691-200312000-00010","volume":"25","author":"GK Isbister","year":"2003","unstructured":"Isbister GK, Hackett LP, Whyte IM. Intentional warfarin overdose. Ther Drug Monit. 2003;25(6):715\u201322. https:\/\/doi.org\/10.1097\/00007691-200312000-00010.","journal-title":"Ther Drug Monit"},{"issue":"2","key":"907_CR10","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1007\/s13181-013-0378-8","volume":"10","author":"M Levine","year":"2014","unstructured":"Levine M, Pizon AF, Padilla-Jones A, Ruha AM. Warfarin Overdose: A 25-Year Experience. J Med Toxicol. 2014;10(2):156\u201364. https:\/\/doi.org\/10.1007\/s13181-013-0378-8.","journal-title":"J Med Toxicol"},{"issue":"2","key":"907_CR11","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.jemermed.2016.05.068","volume":"52","author":"I Berling","year":"2017","unstructured":"Berling I, Mostafa A, Grice JE, Roberts MS, Isbister GK. Warfarin poisoning with delayed rebound toxicity. J Emerg Med. 2017;52(2):194\u20136. https:\/\/doi.org\/10.1016\/j.jemermed.2016.05.068.","journal-title":"J Emerg Med"},{"issue":"5","key":"907_CR12","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1111\/j.1365-2125.1984.tb02526.x","volume":"18","author":"BK Park","year":"1984","unstructured":"Park BK, Scott AK, Wilson AC, Haynes BP, Breckenridge AM. Plasma disposition of vitamin K1 in relation to anticoagulant poisoning. Br J Clin Pharmacol. 1984;18(5):655\u201362. https:\/\/doi.org\/10.1111\/j.1365-2125.1984.tb02526.x.","journal-title":"Br J Clin Pharmacol"},{"issue":"6","key":"907_CR13","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1111\/j.1365-2125.1985.tb05123.x","volume":"20","author":"I Choonara","year":"1985","unstructured":"Choonara I, Scott A, Haynes B, Cholerton S, Breckenridge A, Park B. Vitamin K1 metabolism in relation to pharmacodynamic response in anticoagulated patients. Br J Clin Pharmacol. 1985;20(6):643\u20138. https:\/\/doi.org\/10.1111\/j.1365-2125.1985.tb05123.x.","journal-title":"Br J Clin Pharmacol"},{"key":"907_CR14","unstructured":"Iqbal H. Vitamin K1 (phytonadione). In: Olson KR, Smollin CG, Anderson IB et al., eds. Poisoning & Drug Overdose. 8th ed. McGraw-Hill Education; 2022:596\u2013597."},{"key":"907_CR15","unstructured":"Mephyton(R) (Phytonadione) [Package Insert]. Merck & Company, Incorporated; 2004."},{"issue":"1","key":"907_CR16","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1590\/s1679-45082012000100024","volume":"10","author":"JS Teles","year":"2012","unstructured":"Teles JS, Fukuda EY, Feder D. Warfarin: pharmacological profile and drug interactions with antidepressants. Einstein S\u00e3o Paulo. 2012;10(1):110\u20135. https:\/\/doi.org\/10.1590\/s1679-45082012000100024.","journal-title":"Einstein S\u00e3o Paulo"},{"issue":"5","key":"907_CR17","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1021\/tx1000283","volume":"23","author":"DR Jones","year":"2010","unstructured":"Jones DR, Kim SY, Guderyon M, Yun CH, Moran JH, Miller GP. Hydroxywarfarin metabolites potently inhibit CYP2C9 metabolism of S-warfarin. Chem Res Toxicol. 2010 May 17;23(5):939\u201345. https:\/\/doi.org\/10.1021\/tx1000283.","journal-title":"Chem Res Toxicol"},{"issue":"5","key":"907_CR18","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1111\/j.1365-2125.1978.tb01651.x","volume":"5","author":"E J\u00e4hnchen","year":"1978","unstructured":"J\u00e4hnchen E, Meinertz T, Gilfrich HJ, Kersting F, Groth U. Enhanced elimination of warfarin during treatment with cholestyramine. Br J Clin Pharmacol. 1978;5(5):437\u201340. https:\/\/doi.org\/10.1111\/j.1365-2125.1978.tb01651.x.","journal-title":"Br J Clin Pharmacol"},{"key":"907_CR19","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.2147\/DDDT.S107917","volume":"10","author":"H Li","year":"2016","unstructured":"Li H, Wang Y, Fan R, et al. The effects of ferulic acid on the pharmacokinetics of warfarin in rats after biliary drainage. Drug Des Devel Ther. 2016;10:2173\u201380. https:\/\/doi.org\/10.2147\/DDDT.S107917.","journal-title":"Drug Des Devel Ther"}],"container-title":["Journal of Medical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13181-022-00907-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13181-022-00907-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13181-022-00907-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T15:08:52Z","timestamp":1663772932000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13181-022-00907-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,6]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["907"],"URL":"https:\/\/doi.org\/10.1007\/s13181-022-00907-1","relation":{},"ISSN":["1556-9039","1937-6995"],"issn-type":[{"value":"1556-9039","type":"print"},{"value":"1937-6995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,6]]},"assertion":[{"value":"19 April 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 July 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 July 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 September 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Consent for publication of this case was obtained and provided to the journal in accordance with JMT policy.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"CJW, MDS, JDW, and AP report no conflicts of interest. MMB reports that she is the Pediatric Toxicology Section Editor at UpToDate.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}