{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:22:34Z","timestamp":1792801354763,"version":"4.5.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL166592"],"award-info":[{"award-number":["R01HL166592"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["R21ES031243"],"award-info":[{"award-number":["R21ES031243"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J. Med. Toxicol."],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Carbon monoxide (CO) is a leading cause of environmental poisoning in the United States with substantial mortality and morbidity. The mechanism of CO poisoning is complex and includes hypoxia, inflammation, and mitochondrial dysfunction. Currently both biomarkers and therapies for CO poisoning are limited and require new approaches.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Rats (~\u2009300\u00a0g) were divided into four groups of ten rodents per group (exposure): Control (room air), CO-400 (400 ppm), CO-1000 (1000 ppm) and CO-2000 (2000 ppm). Rodents received the assigned exposure through a secured tracheotomy tube over 120\u00a0min followed by 30\u00a0min of re-oxygenation at room air for a total of 150\u00a0min. Five additional rodents in each group were administered a succinate prodrug (NV354) at the start of exposure for the duration of the experiment until the reoxygenation period as separate experiments. Cortical brain tissue and whole blood were obtained for mitochondrial respiration. Stored plasma and snap frozen tissue stored at -80\n                      <jats:sup>o<\/jats:sup>\n                      C were used to obtain protein quantification with Western Blotting.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All animals in the Sham, CO-400, and CO-1000 groups survived until the end of the exposure period; no animals in the CO-2000 groups survived the exposure and were counted as attrition. We observed a dose-dependent decrease in key respiratory states in both isolated brain mitochondria and peripheral blood mononuclear cells (PBMCs), and, PBMCs respiration more positively correlated with isolated brain mitochondria when compared to carboxyhemoglobin (COHb). There was no significant difference in mitochondrial respiratory states in animals treated with NV354 compared to the untreated group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The primary findings from this study include: (1) A dose-dependent decrease with key respiration states with higher concentrations of CO; (2) PBMCs had a higher correlation to isolated brain mitochondria respiration when compared to COHb; and (3) there was no treatment effect with the use of NV354.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s13181-025-01077-6","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T14:53:10Z","timestamp":1745851990000},"page":"327-335","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Blood Cells as a Cellular Biomarker for Mitochondrial Function in a Experimental Model of Acute Carbon Monoxide Poisoning with Treatment"],"prefix":"10.1007","volume":"21","author":[{"given":"Devesh","family":"Bungatavula","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Greenwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances S.","family":"Shofer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guthrie","family":"Buehler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Han","family":"Kao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel S.","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes K.","family":"Ehinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd J.","family":"Kilbaugh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1213-6971","authenticated-orcid":false,"given":"David H.","family":"Jang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,28]]},"reference":[{"issue":"1","key":"1077_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0300-483X(99)00217-6","volume":"145","author":"JA Raub","year":"2000","unstructured":"Raub JA, Mathieu-Nolf M, Hampson NB, Thom SR. Carbon monoxide poisoning\u2013a public health perspective. Toxicology. 2000;145(1):1\u201314.","journal-title":"Toxicology"},{"issue":"3","key":"1077_CR2","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1016\/j.ajem.2017.08.048","volume":"36","author":"T Ran","year":"2018","unstructured":"Ran T, Nurmagambetov T, Sircar K. Economic implications of unintentional carbon monoxide poisoning in the united States and the cost and benefit of CO detectors. Am J Emerg Med. 2018;36(3):414\u20139.","journal-title":"Am J Emerg Med"},{"issue":"5","key":"1077_CR3","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1164\/rccm.201606-1275CI","volume":"195","author":"JJ Rose","year":"2017","unstructured":"Rose JJ, Wang L, Xu Q, McTiernan CF, Shiva S, Tejero J, Gladwin MT. Carbon monoxide poisoning: pathogenesis, management, and future directions of therapy. Am J Respir Crit Care Med. 2017;195(5):596\u2013606.","journal-title":"Am J Respir Crit Care Med"},{"issue":"6","key":"1077_CR4","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1016\/S0196-0644(96)70192-0","volume":"27","author":"LK Weaver","year":"1996","unstructured":"Weaver LK, Hopkins RO, Larson-Lohr V. Neuropsychologic and functional recovery from severe carbon monoxide poisoning without hyperbaric oxygen therapy. Ann Emerg Med. 1996;27(6):736\u201340.","journal-title":"Ann Emerg Med"},{"issue":"4","key":"1077_CR5","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1097\/00000433-199712000-00017","volume":"18","author":"FA Jaffe","year":"1997","unstructured":"Jaffe FA. Pathogenicity of carbon monoxide. Am J Forensic Med Pathol. 1997;18(4):406\u201310.","journal-title":"Am J Forensic Med Pathol"},{"issue":"3","key":"1077_CR6","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1164\/rccm.200601-117OC","volume":"174","author":"R Favory","year":"2006","unstructured":"Favory R, Lancel S, Tissier S, Mathieu D, Decoster B, Neviere R. Myocardial dysfunction and potential cardiac hypoxia in rats induced by carbon monoxide inhalation. Am J Respir Crit Care Med. 2006;174(3):320\u20135.","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"1077_CR7","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1172\/JCI115633","volume":"89","author":"SD Brown","year":"1992","unstructured":"Brown SD, Piantadosi CA. Recovery of energy metabolism in rat brain after carbon monoxide hypoxia. J Clin Invest. 1992;89(2):666\u201372.","journal-title":"J Clin Invest"},{"key":"1077_CR8","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1146\/annurev.pathol.4.110807.092314","volume":"5","author":"DC Wallace","year":"2010","unstructured":"Wallace DC, Fan W, Procaccio V. Mitochondrial energetics and therapeutics. Annu Rev Pathol. 2010;5:297\u2013348.","journal-title":"Annu Rev Pathol"},{"issue":"Pt 1","key":"1077_CR9","first-page":"1","volume":"284","author":"GC Brown","year":"1992","unstructured":"Brown GC. Control of respiration and ATP synthesis in mammalian mitochondria and cells. Biochem J. 1992;284(Pt 1):1\u201313.","journal-title":"Biochem J"},{"issue":"1","key":"1077_CR10","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/S0021-9258(19)57192-7","volume":"217","author":"B Chance","year":"1955","unstructured":"Chance B, Williams GR. Respiratory enzymes in oxidative phosphorylation. IV. The respiratory chain. J Biol Chem. 1955;217(1):429\u201338.","journal-title":"J Biol Chem"},{"issue":"1","key":"1077_CR11","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/S0021-9258(18)65266-4","volume":"221","author":"B Chance","year":"1956","unstructured":"Chance B, Williams GR. Respiratory enzymes in oxidative phosphorylation. VI. The effects of adenosine diphosphate on azide-treated mitochondria. J Biol Chem. 1956;221(1):477\u201389.","journal-title":"J Biol Chem"},{"issue":"6","key":"1077_CR12","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.1097\/CCM.0b013e3181760c4b","volume":"36","author":"JC d\u2019Avila","year":"2008","unstructured":"d\u2019Avila JC, Santiago AP, Amancio RT, Galina A, Oliveira MF, Bozza FA. Sepsis induces brain mitochondrial dysfunction. Crit Care Med. 2008;36(6):1925\u201332.","journal-title":"Crit Care Med"},{"issue":"1","key":"1077_CR13","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1097\/TA.0b013e3182988b1f","volume":"75","author":"JP Villarroel","year":"2013","unstructured":"Villarroel JP, Guan Y, Werlin E, Selak MA, Becker LB, Sims CA. Hemorrhagic shock and resuscitation are associated with peripheral blood mononuclear cell mitochondrial dysfunction and immunosuppression. J Trauma Acute Care Surg. 2013;75(1):24\u201331.","journal-title":"J Trauma Acute Care Surg"},{"issue":"6","key":"1077_CR14","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1097\/SHK.0000000000000026","volume":"40","author":"MA Karamercan","year":"2013","unstructured":"Karamercan MA, Weiss SL, Villarroel JP, Guan Y, Werlin E, Figueredo R, Becker LB, Sims C. Can peripheral blood mononuclear cells be used as a proxy for mitochondrial dysfunction in vital organs during hemorrhagic shock and resuscitation? Shock. 2013;40(6):476\u201384.","journal-title":"Shock"},{"issue":"5","key":"1077_CR15","doi-asserted-by":"publisher","first-page":"e0302653","DOI":"10.1371\/journal.pone.0302653","volume":"19","author":"JC Greenwood","year":"2024","unstructured":"Greenwood JC, Morgan RW, Abella BS, Shofer FS, Baker WB, Lewis A, Ko TS, Forti RM, Yodh AG, Kao SH, Shin SS, Kilbaugh TJ, Jang DH. Carbon monoxide as a cellular protective agent in a swine model of cardiac arrest protocol. PLoS ONE. 2024;19(5):e0302653.","journal-title":"PLoS ONE"},{"issue":"3","key":"1077_CR16","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1007\/s13181-022-00892-5","volume":"18","author":"A Lewis","year":"2022","unstructured":"Lewis A, Forti RM, Alomaja O, Mesaros C, Piel S, Greenwood JC, Talebi FM, Mavroudis CD, Kelly M, Kao SH, Shofer FS, Ehinger JK, Kilbaugh TJ, Baker WB, Jang DH. Preliminary research: application of Non-Invasive measure of cytochrome C oxidase redox States and mitochondrial function in a Porcine model of carbon monoxide poisoning. J Med Toxicol. 2022;18(3):214\u201322.","journal-title":"J Med Toxicol"},{"issue":"9","key":"1077_CR17","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1080\/15563650.2020.1870691","volume":"59","author":"DH Jang","year":"2021","unstructured":"Jang DH, Piel S, Greenwood JC, Kelly M, Mazandi VM, Ranganathan A, Lin Y, Starr J, Hallowell T, Shofer FS, Baker WB, Lafontant A, Andersen K, Ehinger JK, Kilbaugh TJ. Alterations in cerebral and cardiac mitochondrial function in a Porcine model of acute carbon monoxide poisoning. Clin Toxicol (Phila). 2021;59(9):801\u20139.","journal-title":"Clin Toxicol (Phila)"},{"issue":"5","key":"1077_CR18","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1016\/j.mito.2010.02.001","volume":"10","author":"DT Shaughnessy","year":"2010","unstructured":"Shaughnessy DT, Worth L Jr., Lawler CP, McAllister KA, Longley MJ, Copeland WC. Meeting report: identification of biomarkers for early detection of mitochondrial dysfunction. Mitochondrion. 2010;10(5):579\u201381.","journal-title":"Mitochondrion"},{"key":"1077_CR19","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.mito.2017.12.009","volume":"44","author":"DH Jang","year":"2019","unstructured":"Jang DH, Greenwood JC, Owiredu S, Ranganathan A, Eckmann DM. Mitochondrial networking in human blood cells with application in acute care illnesses. Mitochondrion. 2019;44:27\u201334.","journal-title":"Mitochondrion"},{"issue":"5","key":"1077_CR20","doi-asserted-by":"publisher","first-page":"C699","DOI":"10.1152\/ajpcell.00243.2018","volume":"315","author":"DH Jang","year":"2018","unstructured":"Jang DH, Owiredu S, Ranganathan A, Eckmann DM. Acute decompression following simulated dive conditions alters mitochondrial respiration and motility. Am J Physiol Cell Physiol. 2018;315(5):C699\u2013705.","journal-title":"Am J Physiol Cell Physiol"},{"issue":"1","key":"1077_CR21","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s40635-018-0169-2","volume":"6","author":"DH Jang","year":"2018","unstructured":"Jang DH, Khatri UG, Shortal BP, Kelly M, Hardy K, Lambert DS, Eckmann DM. Alterations in mitochondrial respiration and reactive oxygen species in patients poisoned with carbon monoxide treated with hyperbaric oxygen. Intensive Care Med Exp. 2018;6(1):4.","journal-title":"Intensive Care Med Exp"},{"issue":"6","key":"1077_CR22","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1080\/15563650.2017.1288912","volume":"55","author":"DH Jang","year":"2017","unstructured":"Jang DH, Kelly M, Hardy K, Lambert DS, Shofer FS, Eckmann DM. A preliminary study in the alterations of mitochondrial respiration in patients with carbon monoxide poisoning measured in blood cells. Clin Toxicol (Phila). 2017;55(6):579\u201384.","journal-title":"Clin Toxicol (Phila)"},{"issue":"1","key":"1077_CR23","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1177\/0885066616658449","volume":"32","author":"DH Jang","year":"2017","unstructured":"Jang DH, Greenwood JC, Spyres MB, Eckmann DM. Measurement of mitochondrial respiration and motility in acute care: sepsis, trauma, and poisoning. J Intensive Care Med. 2017;32(1):86\u201394.","journal-title":"J Intensive Care Med"},{"issue":"6","key":"1077_CR24","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1007\/s11010-022-04589-9","volume":"478","author":"S Piel","year":"2023","unstructured":"Piel S, Janowska JI, Ward JL, McManus MJ, Aronowitz DI, Janowski PK, Starr J, Hook JN, Hefti MM, Clayman CL, Elmer E, Hansson MJ, Jang DH, Karlsson M, Ehinger JK, Kilbaugh TJ. Succinate prodrugs as treatment for acute metabolic crisis during fluoroacetate intoxication in the rat. Mol Cell Biochem. 2023;478(6):1231\u201344.","journal-title":"Mol Cell Biochem"},{"issue":"2","key":"1077_CR25","doi-asserted-by":"publisher","first-page":"C269","DOI":"10.1152\/ajpcell.00022.2021","volume":"321","author":"DH Jang","year":"2021","unstructured":"Jang DH, Piel S, Greenwood JC, Ehinger JK, Kilbaugh TJ. Emerging cellular-based therapies in carbon monoxide poisoning. Am J Physiol Cell Physiol. 2021;321(2):C269\u201375.","journal-title":"Am J Physiol Cell Physiol"},{"key":"1077_CR26","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1016\/j.toxrep.2020.09.002","volume":"7","author":"S Owiredu","year":"2020","unstructured":"Owiredu S, Ranganathan A, Greenwood JC, Piel S, Janowska JI, Eckmann DM, Kelly M, Ehinger JK, Kilbaugh TJ, Jang DH. In vitro comparison of hydroxocobalamin (B12a) and the mitochondrial directed therapy by a succinate prodrug in a cellular model of cyanide poisoning. Toxicol Rep. 2020;7:1263\u201371.","journal-title":"Toxicol Rep"},{"issue":"1","key":"1077_CR27","doi-asserted-by":"publisher","first-page":"C129","DOI":"10.1152\/ajpcell.00539.2019","volume":"319","author":"S Owiredu","year":"2020","unstructured":"Owiredu S, Ranganathan A, Eckmann DM, Shofer FS, Hardy K, Lambert DS, Kelly M, Jang DH. Ex vivo use of cell-permeable succinate prodrug attenuates mitochondrial dysfunction in blood cells obtained from carbon monoxide-poisoned individuals. Am J Physiol Cell Physiol. 2020;319(1):C129\u201335.","journal-title":"Am J Physiol Cell Physiol"},{"issue":"4","key":"1077_CR28","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1007\/s13181-023-00956-0","volume":"19","author":"SH Kao","year":"2023","unstructured":"Kao SH, Shofer FS, Greenwood JC, Alomaja O, Ranganathan A, Piel S, Mesaros C, Shin SS, Ehinger JK, Kilbaugh TJ, Jang DH. Cell-Free DNA as a biomarker in a rodent model of Chlorpyrifos poisoning causing mitochondrial dysfunction. J Med Toxicol. 2023;19(4):352\u201361.","journal-title":"J Med Toxicol"},{"issue":"2","key":"1077_CR29","first-page":"196","volume":"19","author":"O Alomaja","year":"2023","unstructured":"Alomaja O, Shofer FS, Greenwood JC, Piel S, Clayman C, Mesaros C, Kao SH, Shin SS, Ehinger JK, Kilbaugh TJ, Jang DH. Alteration in cerebral metabolism in a rodent model of acute Sub-lethal cyanide poisoning. J Med Toxicol. 2023;19(2):196\u2013204.","journal-title":"J Med Toxicol"},{"issue":"1","key":"1077_CR30","doi-asserted-by":"publisher","first-page":"20329","DOI":"10.1038\/s41598-022-24472-3","volume":"12","author":"S Piel","year":"2022","unstructured":"Piel S, Janowska JI, Ward JL, McManus MJ, Jose JS, Starr J, Sheldon M, Clayman CL, Elmer E, Hansson MJ, Jang DH, Karlsson M, Ehinger JK, Kilbaugh TJ. Succinate prodrugs in combination with Atropine and pralidoxime protect cerebral mitochondrial function in a rodent model of acute organophosphate poisoning. Sci Rep. 2022;12(1):20329.","journal-title":"Sci Rep"},{"issue":"2","key":"1077_CR31","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/s13181-015-0478-8","volume":"11","author":"DH Jang","year":"2015","unstructured":"Jang DH, Lampe JW, Becker LB. The potential application of mitochondrial medicine in toxicologic poisoning. J Med Toxicol. 2015;11(2):201\u20137.","journal-title":"J Med Toxicol"},{"key":"1077_CR32","doi-asserted-by":"publisher","unstructured":"Jang DH, Greenwood JC, Owiredu S, Ranganathan A, Eckmann DM. Mitochondrial networking in human blood cells with application in acute care illnesses. Mitochondrion. 2019;44:27\u201334. https:\/\/doi.org\/10.1016\/j.mito.2017.12.009","DOI":"10.1016\/j.mito.2017.12.009"},{"key":"1077_CR33","doi-asserted-by":"publisher","unstructured":"Jang DH, Khatri UG, Kelly BPS, Hardy M, Lambert K, Eckmann DS, et al. Alterations in mitochondrial respiration and reactive oxygen species in patients poisoned with carbon monoxide treated with hyperbaric oxygen. Intensive Care Med Exp. 2018;6(1):4. https:\/\/doi.org\/10.1186\/s40635-018-0169-2","DOI":"10.1186\/s40635-018-0169-2"},{"key":"1077_CR34","unstructured":"Jang DH, Piel S, Greenwood JC, Kelly M, Mazandi VM, Ranganathan A, et al. Alterations in cerebral and cardiac mitochondrial function in a Porcine model of acute carbon monoxide poisoning. Clin Toxicol (Phila). 2021:1\u201314."},{"key":"1077_CR35","doi-asserted-by":"publisher","unstructured":"Mavroudis CD, Lewis A, Greenwood JC, Kelly M, Ko TS, Forti RM, et al. Investigation of cerebral mitochondrial injury in a porcine survivor model of carbon monoxide poisoning. J Med Toxicol. 2024;20(1):39\u201348. https:\/\/doi.org\/10.1007\/s13181-023-00971-1","DOI":"10.1007\/s13181-023-00971-1"},{"issue":"5","key":"1077_CR36","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1097\/SHK.0000000000001208","volume":"51","author":"DH Jang","year":"2019","unstructured":"Jang DH, Orloski CJ, Owiredu S, Shofer FS, Greenwood JC, Eckmann DM. Alterations in mitochondrial function in blood cells obtained from patients with Sepsis presenting to an emergency department. Shock. 2019;51(5):580\u20134.","journal-title":"Shock"},{"issue":"2","key":"1077_CR37","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1007\/s13181-018-0656-6","volume":"14","author":"DH Jang","year":"2018","unstructured":"Jang DH, Khatri UG, Mudan A, Love JS, Owiredu S, Eckmann DM. Translational application of measuring mitochondrial functions in blood cells obtained from patients with acute poisoning. J Med Toxicol. 2018;14(2):144\u201351.","journal-title":"J Med Toxicol"}],"container-title":["Journal of Medical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13181-025-01077-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13181-025-01077-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13181-025-01077-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T10:28:32Z","timestamp":1751020112000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13181-025-01077-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,28]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["1077"],"URL":"https:\/\/doi.org\/10.1007\/s13181-025-01077-6","relation":{},"ISSN":["1556-9039","1937-6995"],"issn-type":[{"value":"1556-9039","type":"print"},{"value":"1937-6995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,28]]},"assertion":[{"value":"25 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 April 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 April 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 April 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"In this large animal study, all procedures were approved by the Institutional Animal Care and Use Committee at the Children\u2019s Hospital of Philadelphia (CHOP) and performed in accordance with the National Institutes of Health Guide for the Care and Use of Laboratory Animals.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"DJ Grant: R01HL166592.TJK grant: R01HL141386.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"All Source of Support in the form of Grants, Gifts, Equipment, and\/or Drugs"}}]}}