{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T12:40:14Z","timestamp":1792586414093,"version":"4.5.0"},"reference-count":9,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"National Institute on Drug Abuse of the National Institutes of Health","award":["R01DA048009"],"award-info":[{"award-number":["R01DA048009"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J. Med. Toxicol."],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1007\/s13181-026-01146-4","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T19:10:01Z","timestamp":1784661001000},"page":"490-492","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["An Emerging Synthetic Opioid in the Drug Supply: A Case of Opioid Overdose with Biological Confirmation of Cychlorphine"],"prefix":"10.1007","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5331-5119","authenticated-orcid":false,"given":"Rebecca","family":"Kusko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Liss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey L.","family":"House","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena B.","family":"House","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Krotulski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Aldy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"On behalf of the Toxicology Investigators Consortium (ToxIC) Fentalog Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,21]]},"reference":[{"key":"1146_CR1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0000000000001446","author":"E Marchei","year":"2026","unstructured":"Marchei E, Graziano S, Pichini S, Farr\u00e9 M. Brorphine and its analogues: pharmacology, toxicology, and biomonitoring. Ther Drug Monit. 2026. https:\/\/doi.org\/10.1097\/FTD.0000000000001446.","journal-title":"Ther Drug Monit"},{"issue":"2","key":"1146_CR2","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1111\/1556-4029.14623","volume":"66","author":"AJ Krotulski","year":"2021","unstructured":"Krotulski AJ, Papsun DM, Noble C, Kacinko SL, Logan BK. Brorphine-Investigation and quantitation of a new potent synthetic opioid in forensic toxicology casework using liquid chromatography-mass spectrometry. J Forensic Sci. 2021;66(2):664\u201376. https:\/\/doi.org\/10.1111\/1556-4029.14623.","journal-title":"J Forensic Sci"},{"key":"1146_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2024.110113","volume":"260","author":"MM Vandeputte","year":"2024","unstructured":"Vandeputte MM, Bilel S, Tirri M, Corli G, Bassi M, Layle NK, et al. Elucidating the harm potential of brorphine analogues as new synthetic opioids: synthesis, in vitro, and in vivo characterization. Neuropharmacology. 2024;260:110113. https:\/\/doi.org\/10.1016\/j.neuropharm.2024.110113.","journal-title":"Neuropharmacology"},{"issue":"6","key":"1146_CR4","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1515\/cclm-2025-1428","volume":"64","author":"P Dugues","year":"2026","unstructured":"Dugues P, Robin T, Bellouard M, Chenorhokian S, Triguel M, Pfau G, Feng C, Cherki S, Herbette G, Alvarez JC, Larabi IA. Multi-analytical identification of the synthetic opioids cychlorphine and methiodone (IC-26) in drug seizures: first detection in Europe. Clin Chem Lab Med. 2026;64(6):1413\u201324. https:\/\/doi.org\/10.1515\/cclm-2025-1428.","journal-title":"Clin Chem Lab Med"},{"key":"1146_CR5","unstructured":"Marland V. Increasing nitazene and orphine analogues (synthetic opioids) and the implications for the use of test strips. In: UNODC Early Warning Advisory on New Psychoactive Substances. 2026. https:\/\/www.unodc.org\/LSS\/Announcement\/Details\/e69b2ff5-5b91-4eea-8e1f-802ca7ad5080. Accessed 31st May 2026."},{"key":"1146_CR6","unstructured":"Krotulski AJ, Papsun DM, Stang BN, Walton SE, Logan BK, Center for forensic science research and education. increase in fatal overdoses linked to novel synthetic opioid N-Propionitrile Chlorphine (Cychlorphine). 2026. https:\/\/www.cfsre.org\/nps-discovery\/public-alerts\/increase-in-fatal-overdoses-linked-to-novel-synthetic-opioid-n-propionitrile-chlorphine-cychlorphine. Accessed 31st May 2026."},{"key":"1146_CR7","unstructured":"Cychlorphine. a synthetic opioid involved in at least 55 deaths, has potential to spread across Nation. In: ONDCP drug threat notice. Office of Drug Control Policy (ONDCP). 2026. https:\/\/com-phhp-epi-ndews.sites.medinfo.ufl.edu\/wordpress\/files\/2026\/05\/ONDCP-Drug-Threat-Notice-Cychlorohine_Final.pdf. Accessed 31st May 2026."},{"issue":"5","key":"1146_CR8","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1111\/add.70289","volume":"121","author":"JS Love","year":"2026","unstructured":"Love JS, Vargas-Torres C, Aldy K, Brent J, Wax P, Culbreth R, Krotulski A, Campleman S, Logan B, Abston S, Li S, Manini AF, Fentalog Study Group. Clinical factors linked to xylazine exposure in emergency department patients with illicit opioid overdose. Addiction. 2026;121(5):1227\u201336. https:\/\/doi.org\/10.1111\/add.70289.","journal-title":"Addiction"},{"issue":"2","key":"1146_CR9","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1080\/15563650.2025.2594070","volume":"64","author":"JE Sprague","year":"2026","unstructured":"Sprague JE, Toms JA, Ratermann CF. Non-fatal opioid overdose associated predominantly with the benzimidazolone, cychlorphine. Clin Toxicol (Phila). 2026;64(2):146\u20137. https:\/\/doi.org\/10.1080\/15563650.2025.2594070.","journal-title":"Clin Toxicol (Phila)"}],"container-title":["Journal of Medical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13181-026-01146-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13181-026-01146-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13181-026-01146-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:37:53Z","timestamp":1790948273000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13181-026-01146-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,21]]},"references-count":9,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["1146"],"URL":"https:\/\/doi.org\/10.1007\/s13181-026-01146-4","relation":{},"ISSN":["1556-9039","1937-6995"],"issn-type":[{"value":"1556-9039","type":"print"},{"value":"1937-6995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,21]]},"assertion":[{"value":"29 June 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 July 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 July 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 July 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Consent was not available, but this case was anonymized according to JMT guidelines and publication was approved after review by members of the editorial board because the manuscript primarily focuses on the laboratory result and public health implications identified during this clinical event.","order":1,"name":"Ethics","label":"Compliance with Ethical standards","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None.","order":2,"name":"Ethics","label":"Previous presentations","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None to declare.","order":3,"name":"Ethics","label":"Conflicts of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}