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This study examined the feasibility and acceptability of a guided biopsychosocial online intervention for cancer patients undergoing chemotherapy (OPaCT). A pre-post, within-participant comparison, mixed-methods research design was followed. Patients starting chemotherapy at the outpatient clinic of the National Center for Tumor Diseases in Heidelberg, Germany, were enrolled. Feasibility and acceptability were evaluated through intervention uptake, attrition, adherence and participant satisfaction. As secondary outcomes, PHQ-9, GAD-7, SCNS-SF34-G and CBI-B-D were administered. A total of <jats:italic>N<\/jats:italic>\u2009=\u200946 patients participated in the study (female 76.1%). The age of participants ranged from 29 to 70\u00a0years (<jats:italic>M<\/jats:italic>\u2009=\u200949.3, SD\u2009=\u200911.3). The most prevalent tumour diseases were breast (45.7%), pancreatic (19.6%), ovarian (13.1%) and prostate cancer (10.8%). A total of <jats:italic>N<\/jats:italic>\u2009=\u200937 patients (80.4%) completed the OPaCT intervention. Qualitative and quantitative data showed a high degree of participant satisfaction. Significant improvements in the SCNS-SF34 subscale \u2018psychological needs\u2019 were found. Study results demonstrate the feasibility and acceptability of the intervention. The results show that OPaCT can be implemented well, both in the treatment process and in participants\u2019 everyday lives. Although it is premature to make any determination regarding the efficacy of the intervention tested in this feasibility study, these results suggest that OPaCT has the potential to reduce unmet psychological care needs of patients undergoing chemotherapy.<\/jats:p>","DOI":"10.1007\/s13187-020-01792-4","type":"journal-article","created":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T18:04:30Z","timestamp":1592503470000},"page":"102-110","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Acceptability and Feasibility of a Guided Biopsychosocial Online Intervention for Cancer Patients Undergoing Chemotherapy"],"prefix":"10.1007","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3837-0931","authenticated-orcid":false,"given":"Miriam","family":"Grapp","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4147-2958","authenticated-orcid":false,"given":"Friederike","family":"Rosenberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0427-4127","authenticated-orcid":false,"given":"Elena","family":"Hemlein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8298-3631","authenticated-orcid":false,"given":"Eva","family":"Klein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4344-8959","authenticated-orcid":false,"given":"Hans-Christoph","family":"Friederich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8030-1182","authenticated-orcid":false,"given":"Imad","family":"Maatouk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,6,18]]},"reference":[{"key":"1792_CR1","doi-asserted-by":"publisher","first-page":"3540","DOI":"10.1200\/JCO.2014.56.0086","volume":"32","author":"A Mehnert","year":"2014","unstructured":"Mehnert A, Br\u00e4hler E, Faller H, H\u00e4rter M, Keller M, Schulz H, Wegscheider K, Weis J, Boehncke A, Hund B, Reuter K (2014) Four-week prevalence of mental disorders in patients with cancer across major tumor entities. 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