{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T16:43:14Z","timestamp":1770050594626,"version":"3.49.0"},"reference-count":7,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Tata Memorial Hospital - TMC"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Indian J Surg Oncol"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Hepatocellular carcinoma (HCC) presenting as calvarial metastasis (CM) is a rare situation with limited reports in literature. We present a case of a 64-year-old gentleman, who presented with an 8-month history of swelling on the right forehead, associated with decreased vision and size of the right eye. Magnetic resonance imaging revealed a partially hemorrhagic lesion in the right frontal bone, extending into the scalp and causing a midline shift, with intra-orbital and intraconal extension. Positron emission tomography showed multiple bi-lobar liver metastases. The patient was diagnosed with hepatitis B\u2013associated hepatocellular carcinoma on biopsy and was started on dexamethasone, anti-epileptic prophylaxis, and Lenvatinib. He also received focal radiotherapy for the CM. Advanced imaging techniques were crucial in diagnosing the disease\u2019s extent. The patient\u2019s management, involving pharmacological therapy, radiotherapy, and supportive care, highlights the need for a multidisciplinary approach in treating advanced malignancies.<\/jats:p>","DOI":"10.1007\/s13193-025-02324-6","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T03:45:32Z","timestamp":1747626332000},"page":"252-254","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Calvarial Metastasis as the Initial Presentation in Hepatocellular Carcinoma: A Rare Entity"],"prefix":"10.1007","volume":"17","author":[{"given":"Katyayani","family":"Kumari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5363-4005","authenticated-orcid":false,"given":"Abdeali Saif Arif","family":"Kaderi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8489-6825","authenticated-orcid":false,"given":"Shraddha","family":"Patkar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,5,19]]},"reference":[{"key":"2324_CR1","doi-asserted-by":"publisher","unstructured":"Shuto T, Hirohashi K, Kubo S, Tanaka H, Yamamoto T, Higaki I, Takemura S, Kinoshita H (2001) Treatment of adrenal metastases after hepatic resection of a hepatocellular carcinoma. 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J Gastrointest Cancer 48(4):321\u2013325. https:\/\/doi.org\/10.1007\/s12029-017-9998-6","journal-title":"J Gastrointest Cancer"},{"issue":"16","key":"2324_CR4","doi-asserted-by":"publisher","first-page":"6","DOI":"10.25259\/SNI_507_2024","volume":"10","author":"JW Chen","year":"2025","unstructured":"Chen JW, Giridharan N, Kavoussi AA, Van Arsdale D, Hosseingholi Nouri S, Nitturi V, Trudeau T, Mandel JJ, Lu HC, Patel AJ (2025) Isolated calvarial lesion as the initial presentation of metastatic hepatocellular carcinoma: a case report and review of the literature. Surg Neurol Int 10(16):6. https:\/\/doi.org\/10.25259\/SNI_507_2024","journal-title":"Surg Neurol Int"},{"issue":"1","key":"2324_CR5","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1002\/ajh.26760","volume":"98","author":"AC Hristov","year":"2023","unstructured":"Hristov AC, Tejasvi T, Wilcox RA (2023) Cutaneous T-cell lymphomas: 2023 update on diagnosis, risk-stratification, and management. Am J Hematol 98(1):193\u2013209. https:\/\/doi.org\/10.1002\/ajh.26760","journal-title":"Am J Hematol"},{"issue":"4","key":"2324_CR6","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1055\/s-0042-1757626","volume":"17","author":"S Gupta","year":"2022","unstructured":"Gupta S, Sharma G, Sajeevan S, Raut SN, Ahuja R, Joseph D, et al. Varied clinical presentation and management of calvarial metastases. Asian J Neurosurg. 2022 Oct 18;17(4):631\u20134","journal-title":"Asian J Neurosurg"},{"key":"2324_CR7","doi-asserted-by":"publisher","unstructured":"Huang A, Yang XR, Chung WY, Dennison AR, Zhou J (2020) Targeted therapy for hepatocellular carcinoma. Signal Transduct Target Ther 5(1):146. https:\/\/doi.org\/10.1038\/s41392-020-00264-x","DOI":"10.1038\/s41392-020-00264-x"}],"container-title":["Indian Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13193-025-02324-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13193-025-02324-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13193-025-02324-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T06:20:20Z","timestamp":1770013220000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13193-025-02324-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,19]]},"references-count":7,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["2324"],"URL":"https:\/\/doi.org\/10.1007\/s13193-025-02324-6","relation":{},"ISSN":["0975-7651","0976-6952"],"issn-type":[{"value":"0975-7651","type":"print"},{"value":"0976-6952","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,19]]},"assertion":[{"value":"13 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The corresponding author is section editor for the journal.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Patient\u2019s consent has been taken for photography and publication. Patient\u2019s details have not been revealed in any part of the manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Patient\u2019s Consent"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interest"}}]}}