{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:03:01Z","timestamp":1790643781906,"version":"4.1.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Indian J Surg Oncol"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1007\/s13193-025-02500-8","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T06:23:34Z","timestamp":1768976614000},"page":"2039-2047","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["p16INK4a Promoter Hypermethylation in Gallbladder Cancer"],"prefix":"10.1007","volume":"17","author":[{"given":"Satya P.","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7005-9436","authenticated-orcid":false,"given":"Mallika","family":"Tewari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alok K.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raghvendra R.","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hari S.","family":"Shukla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,21]]},"reference":[{"issue":"5","key":"2500_CR1","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.1158\/1078-0432.CCR-1137-3","volume":"10","author":"T Ueki Jr","year":"2004","unstructured":"Ueki T, Hsing AW, Gao YT, Wang BS, Shen MC, Cheng J, Deng J, Fraumeni JF Jr, Rashid A (2004) Alterations of p16 and prognosis in biliary tract cancers from a population-based study in China. Clin Cancer Res 10(5):1717\u20131725","journal-title":"Clin Cancer Res"},{"issue":"4","key":"2500_CR2","doi-asserted-by":"publisher","first-page":"311","DOI":"10.4103\/ijmr.IJMR_501_18","volume":"151","author":"S Bhunia","year":"2020","unstructured":"Bhunia S, Barbhuiya MA, Gupta S, Shrivastava BR, Tiwari PK (2020) Epigenetic downregulation of Desmin in gall bladder cancer reveals its potential role in disease progression. Indian J Med Res 151(4):311","journal-title":"Indian J Med Res"},{"issue":"7","key":"2500_CR3","doi-asserted-by":"publisher","first-page":"293","DOI":"10.4103\/1947-2714.98586","volume":"4","author":"\u00c5 Andr\u00e9n-Sandberg","year":"2012","unstructured":"Andr\u00e9n-Sandberg \u00c5 (2012) Diagnosis and management of gallbladder cancer. North Am J Med Sci 4(7):293","journal-title":"North Am J Med Sci"},{"issue":"3","key":"2500_CR4","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1002\/gcc.10315","volume":"39","author":"N Hu","year":"2004","unstructured":"Hu N, Wang C, Su H, Li WJ, Emmert-Buck MR, Li G, Roth MJ, Tang ZZ, Lu N, Giffen C Albert PS (2004) High frequency of CDKN2A alterations in esophageal squamous cell carcinoma from a high\u2010risk Chinese population. Genes Chromosom Cancer 39(3):205\u2013216","journal-title":"Genes Chromosom Cancer"},{"key":"2500_CR5","doi-asserted-by":"crossref","unstructured":"Tadokoro H, Shigihara T, Ikeda T, Takase M, Suyama M (2007) Two distinct pathways of p16 gene inactivation in gallbladder cancer. World J Gastroenterology: WJG 13(47):6396\u20136403","DOI":"10.3748\/wjg.v13.i47.6396"},{"issue":"5293","key":"2500_CR6","doi-asserted-by":"publisher","first-page":"1672","DOI":"10.1126\/science.274.5293.1672","volume":"274","author":"CJ Sherr","year":"1996","unstructured":"Sherr CJ (1996) Cancer cell cycles. Science 274(5293):1672\u20131677","journal-title":"Science"},{"issue":"3","key":"2500_CR7","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/0092-8674(95)90385-2","volume":"81","author":"RA Weinberg","year":"1995","unstructured":"Weinberg RA (1995) The retinoblastoma protein and cell cycle control. Cell 81(3):323\u2013330","journal-title":"Cell"},{"issue":"4","key":"2500_CR8","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1111\/ajco.12507","volume":"12","author":"DS Tekcham","year":"2016","unstructured":"Tekcham DS, Tiwari PK (2016) Epigenetic regulation in gallbladder cancer: promoter methylation profiling as emergent novel biomarkers. Asia-Pac J Clin Oncol 12(4):332\u2013348","journal-title":"Asia-Pac J Clin Oncol"},{"issue":"8","key":"2500_CR9","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1245\/ASO.2003.02.014","volume":"10","author":"MG House","year":"2003","unstructured":"House MG, Wistuba II, Argani P, Guo M, Schulick RD, Hruban RH, Herman JG, Maitra A (2003) Progression of gene hypermethylation in gallstone disease leading to gallbladder cancer. Ann Surg Oncol 10(8):882\u2013889","journal-title":"Ann Surg Oncol"},{"issue":"7","key":"2500_CR10","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1016\/j.trecan.2020.03.003","volume":"6","author":"PK Tiwari","year":"2020","unstructured":"Tiwari PK (2020) Epigenetic biomarkers in gallbladder cancer. Trends Cancer 6(7):540\u2013543","journal-title":"Trends Cancer"},{"issue":"1","key":"2500_CR11","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/S0304-3835(01)00562-6","volume":"169","author":"YT Kim","year":"2001","unstructured":"Kim YT, Kim J, Jang YH, Lee WJ, Ryu JK, Park YK, Kim SW, Kim WH, Yoon YB, Kim CY (2001) Genetic alterations in gallbladder adenoma, dysplasia and carcinoma. Cancer Lett 169(1):59\u201368","journal-title":"Cancer Lett"},{"issue":"3","key":"2500_CR12","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.humpath.2006.09.004","volume":"38","author":"RD DeHaan","year":"2007","unstructured":"DeHaan RD, Kipp BR, Smyrk TC, Abraham SC, Roberts LR, Halling KC (2007) An assessment of chromosomal alterations detected by fluorescence in situ hybridization and p16 expression in sporadic and primary sclerosing cholangitis-associated cholangiocarcinomas. Hum Pathol 38(3):491\u2013499","journal-title":"Hum Pathol"},{"issue":"3","key":"2500_CR13","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1007\/s13193-021-01325-5","volume":"12","author":"M Sugara","year":"2021","unstructured":"Sugara M, Chowdappa R, Kumar KV, Gawari R, Swamy SN, Kumar SS (2021) Aberrant promoter hypermethylation of p16 and RASSF1a genes in colorectal Cancer\u2013Significance in young patients. Indian J Surg Oncol 12(3):454\u2013459","journal-title":"Indian J Surg Oncol"},{"key":"2500_CR14","doi-asserted-by":"publisher","first-page":"114320","DOI":"10.1016\/j.bcp.2020.114320","volume":"183","author":"HJ Bae","year":"2021","unstructured":"Bae HJ, Kang SK, Kwon WS, Jeong I, Park S, Kim TS, Kim KH, Kim H, Jeong HC, Chung HC, Rha SY (2021) p16 methylation is a potential predictive marker for abemaciclib sensitivity in gastric cancer. Biochem Pharmacol 183:114320","journal-title":"Biochem Pharmacol"},{"issue":"1","key":"2500_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2407-11-27","volume":"11","author":"S Hedau","year":"2011","unstructured":"Hedau S, Kumar U, Hussain S, Shukla S, Pande S, Jain N, Tyagi A, Deshpande T, Bhat D, Mir MM, Chakraborty S (2011) Breast cancer and human papillomavirus infection: no evidence of HPV etiology of breast cancer in Indian women. BMC Cancer 11(1):1\u20130","journal-title":"BMC Cancer"},{"key":"2500_CR16","doi-asserted-by":"crossref","unstructured":"Herman JG, Graff JR, My\u00f6h\u00e4nen SB, Nelkin BD, Baylin SB (1996) Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Nat Acad Sci USA 93(18):9821-6","DOI":"10.1073\/pnas.93.18.9821"},{"issue":"5","key":"2500_CR17","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1016\/j.ebiom.2015.03.015","volume":"2","author":"H Liu","year":"2015","unstructured":"Liu H, Liu XW, Dong G, Zhou J, Liu Y, Gao Y, Liu XY, Gu L, Sun Z, Deng D (2015) P16 Methylation as an early predictor for cancer development from oral epithelial dysplasia: a double-blind multicentre prospective study. EBioMedicine 2(5):432\u2013437","journal-title":"EBioMedicine"},{"issue":"8","key":"2500_CR18","first-page":"3225","volume":"61","author":"M Esteller","year":"2001","unstructured":"Esteller M, Corn PG, Baylin SB, Herman JG (2001) A gene hypermethylation profile of human cancer. Cancer Res 61(8):3225\u20133229","journal-title":"Cancer Res"},{"issue":"2","key":"2500_CR19","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1038\/72785","volume":"24","author":"JF Costello","year":"2000","unstructured":"Costello JF, Fr\u00fchwald MC, Smiraglia DJ, Rush LJ, Robertson GP, Gao X, Wright FA, Feramisco JD, Peltom\u00e4ki P, Lang JC, Schuller DE (2000) Aberrant CpG-island methylation has non-random and tumour-type\u2013specific patterns. Nat Genet 24(2):132\u2013138","journal-title":"Nat Genet"},{"key":"2500_CR20","first-page":"99","volume":"6","author":"R Hundal","year":"2014","unstructured":"Hundal R, Shaffer EA (2014) Gallbladder cancer: epidemiology and outcome. Clin Epidemiol 6:99","journal-title":"Clin Epidemiol"},{"issue":"12","key":"2500_CR21","doi-asserted-by":"publisher","first-page":"S108","DOI":"10.1016\/j.ijsu.2014.08.367","volume":"1","author":"A Cavallaro","year":"2014","unstructured":"Cavallaro A, Piccolo G, Di Vita M, Zangh\u00ec A, Card\u00ec F, Di Mattia P, Barbera G, Borz\u00ec L, Panebianco V, Di Carlo I, Cavallaro M (2014) Managing the incidentally detected gallbladder cancer: algorithms and controversies. Int J Surg 1(12):S108\u2013S119","journal-title":"Int J Surg"},{"issue":"8","key":"2500_CR22","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.1007\/s00268-011-1134-3","volume":"35","author":"D Le Fuks","year":"2011","unstructured":"Fuks D, Regimbeau JM, Le Treut YP, Bachellier P, Raventos A, Pruvot FR, Chiche L, Farges O (2011) Incidental gallbladder cancer by the AFC-GBC-2009 study group. World J Surg 35(8):1887\u20131897","journal-title":"World J Surg"},{"issue":"7","key":"2500_CR23","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1002\/ijc.21683","volume":"118","author":"G La Randi","year":"2006","unstructured":"Randi G, Franceschi S, La Vecchia C (2006) Gallbladder cancer worldwide: geographical distribution and risk factors. Int J Cancer 118(7):1591\u20131602","journal-title":"Int J Cancer"},{"issue":"5","key":"2500_CR24","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1001\/archsurg.2009.46","volume":"144","author":"IT Konstantinidis","year":"2009","unstructured":"Konstantinidis IT, Deshpande V, Genevay M, Berger D, Fernandez-del Castillo C, Tanabe KK, Zheng H, Lauwers GY, Ferrone CR (2009) Trends in presentation and survival for gallbladder cancer during a period of more than 4 decades: a single-institution experience. Arch Surg 144(5):441\u2013447","journal-title":"Arch Surg"},{"issue":"2","key":"2500_CR25","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1200\/JCO.2001.19.2.299","volume":"9","author":"M Esteller","year":"2001","unstructured":"Esteller M, Gonzalez S, Risques RA, Marcuello E, Mangues R, Germa JR, Herman JG, Capella G, Peinado MA (2001) K-ras and p16 aberrations confer poor prognosis in human colorectal cancer. J Clin Oncol 9(2):299\u2013304","journal-title":"J Clin Oncol"},{"issue":"11","key":"2500_CR26","first-page":"1369","volume":"132","author":"JC de Roa","year":"2004","unstructured":"Roa JC, Vo Q, Araya JC, Villaseca M, Guzm\u00e1n P, Ibacache G, de Aretxabala X, Roa I (2004) Inactivaci\u00f3n Del gen CDKN2A (p16) En c\u00e1ncer de La ves\u00edcula biliar. Revista m\u00e9dica de Chile 132(11):1369\u20131376","journal-title":"Revista m\u00e9dica de Chile"},{"issue":"1","key":"2500_CR27","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1111\/j.1572-0241.1999.00786.x","volume":"94","author":"ZR Khan","year":"1999","unstructured":"Khan ZR, Neugut AI, Ahsan H, Chabot JA (1999) Risk factors for biliary tract cancers. Am J Gastroenterol 94(1):149\u2013152","journal-title":"Am J Gastroenterol"},{"issue":"10","key":"2500_CR28","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.1002\/1097-0142(19951115)76:10<1747::AID-CNCR2820761011>3.0.CO;2-L","volume":"76","author":"BL Strom","year":"1995","unstructured":"Strom BL, Soloway RD, Rios-Dalenz JL, Rodriguez\u2010Martinez HA, West SL, Kinman JL, Polansky M, Berlin JA (1995) Risk factors for gallbladder cancer. An international collaborative case\u2013control study. Cancer 76(10):1747\u20131756","journal-title":"Cancer"},{"issue":"4","key":"2500_CR29","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1016\/S0016-5085(98)70266-5","volume":"115","author":"JF Del Miquel","year":"1998","unstructured":"Miquel JF, Covarrubias C, Villaroel L, Mingrone G, Greco AV, Puglielli L, Carvallo P, Marshall G, Del Pino G, Nervi F (1998) Genetic epidemiology of cholesterol cholelithiasis among Chilean Hispanics, Amerindians, and Maoris. Gastroenterology 115(4):937\u2013946","journal-title":"Gastroenterology"},{"issue":"3","key":"2500_CR30","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1007\/s00535-005-1752-3","volume":"41","author":"JC Roa","year":"2006","unstructured":"Roa JC, Anabal\u00f3n L, Roa I, Melo A, Araya JC, Tapia O, Aretxabala XD, Mu\u00f1oz S, Schneider B (2006) promoter methylation profile in gallbladder cancer. J Gastroenterol 41(3):269\u2013275","journal-title":"J Gastroenterol"},{"key":"2500_CR31","doi-asserted-by":"crossref","unstructured":"Lv X, Ye G, Zhang X, Huang T (2017) p16 Methylation was associated with the development, age, hepatic viruses infection of hepatocellular carcinoma, and p16 expression had a poor survival: a systematic meta-analysis (PRISMA). Medicine 96(38)","DOI":"10.1097\/MD.0000000000008106"},{"issue":"18","key":"2500_CR32","doi-asserted-by":"publisher","first-page":"6119","DOI":"10.1158\/1078-0432.CCR-04-0652","volume":"15","author":"J Wang","year":"2004","unstructured":"Wang J, Lee JJ, Wang L, Liu DD, Lu C, Fan YH, Hong WK, Mao L (2004) Value of p16 INK4a and RASSF1A promoter hypermethylation in prognosis of patients with resectable non\u2013small cell lung cancer. Clin Cancer Res 15(18):6119\u20136125","journal-title":"Clin Cancer Res"},{"issue":"1","key":"2500_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep29922","volume":"6","author":"X Luo","year":"2016","unstructured":"Luo X, Huang R, Sun H, Liu Y, Bi H, Li J, Yu H, Sun J, Lin S, Cui B, Zhao Y (2016) Methylation of a panel of genes in peripheral blood leukocytes is associated with colorectal cancer. Sci Rep 6(1):1\u20130","journal-title":"Sci Rep"},{"issue":"5","key":"2500_CR34","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1002\/ijc.26061","volume":"129","author":"R Nagashio","year":"2011","unstructured":"Nagashio R, Arai E, Ojima H, Kosuge T, Kondo Y, Kanai Y (2011) Carcinogenetic risk estimation based on quantification of DNA methylation levels in liver tissue at the precancerous stage. Int J Cancer 129(5):1170\u20131179","journal-title":"Int J Cancer"},{"issue":"8","key":"2500_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12032-017-1007-1","volume":"34","author":"A Saadallah-Kallel","year":"2017","unstructured":"Saadallah-Kallel A, Abdelmaksoud-Dammak R, Triki M, Charfi S, Khabir A, Sallemi-Boudawara T, Mokdad-Gargouri R (2017) Clinical and prognosis value of the CIMP status combined with MLH1 or p16 INK4a methylation in colorectal cancer. Med Oncol 34(8):1\u20139","journal-title":"Med Oncol"},{"issue":"2","key":"2500_CR36","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1002\/ijc.28684","volume":"135","author":"T Sato","year":"2014","unstructured":"Sato T, Arai E, Kohno T, Takahashi Y, Miyata S, Tsuta K, Watanabe SI, Soejima K, Betsuyaku T, Kanai Y (2014) Epigenetic clustering of lung adenocarcinomas based on DNA methylation profiles in adjacent lung tissue: Its correlation with smoking history and chronic obstructive pulmonary disease. Int J Cancer 135(2):319\u2013334","journal-title":"Int J Cancer"},{"issue":"4","key":"2500_CR37","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1158\/1078-0432.CCR-11-2011","volume":"15","author":"T Ushijima","year":"2012","unstructured":"Ushijima T, Hattori N (2012) Molecular pathways: involvement of Helicobacter pylori\u2013Triggered inflammation in the formation of an epigenetic field Defect, and its usefulness as cancer risk and exposure markers epigenetic field by H. pylori infection. Clin Cancer Res 15(4):923\u2013929","journal-title":"Clin Cancer Res"},{"issue":"1","key":"2500_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12885-018-4921-5","volume":"18","author":"X Ye","year":"2018","unstructured":"Ye X, Mo M, Xu S, Yang Q, Wu M, Zhang J, Chen B, Li J, Zhong Y, Huang Q, Cai C (2018) The hypermethylation of p16 gene exon 1 and exon 2: potential biomarkers for colorectal cancer and are associated with cancer pathological staging. BMC Cancer 18(1):1\u20130","journal-title":"BMC Cancer"},{"issue":"1","key":"2500_CR39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s43042-019-0027-0","volume":"20","author":"AA Seif","year":"2019","unstructured":"Seif AA, Aly HH, Elzoghby DM, Elbreedy AM, Lotfy M (2019) Aberrant p16 methylation as an early diagnostic marker in blood of hepatocellular carcinoma patients. Egypt J Med Hum Genet 20(1):1\u20139","journal-title":"Egypt J Med Hum Genet"},{"key":"2500_CR40","doi-asserted-by":"publisher","first-page":"7","DOI":"10.4103\/jcar.JCar_4_21","volume":"9","author":"A Gupta","year":"2021","unstructured":"Gupta A, Gupta S, Mani R, Durgapal P, Goyal B, Rajput D et al (2021) Expression of Human epidermal growth factor receptor 2, Survivin, Enhancer of zeste homolog \u2013\u20092, Cyclooxygenase-2, p53 and p16 molecular markers in Gall bladder carcinoma. J Carcinog 9;20:7","journal-title":"J Carcinog"},{"issue":"3","key":"2500_CR41","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.anndiagpath.2007.06.003","volume":"12","author":"BC Lynch","year":"2008","unstructured":"Lynch BC, Lathrop SL, Ye D, Ma TY, Cerilli LA (2008) Expression of the p16(INK4a) gene product in premalignant and malignant epithelial lesions of the gallbladder. Ann Diagn Pathol 12(3):161\u2013164","journal-title":"Ann Diagn Pathol"}],"container-title":["Indian Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13193-025-02500-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13193-025-02500-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13193-025-02500-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:21:54Z","timestamp":1790641314000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13193-025-02500-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,21]]},"references-count":41,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["2500"],"URL":"https:\/\/doi.org\/10.1007\/s13193-025-02500-8","relation":{},"ISSN":["0975-7651","0976-6952"],"issn-type":[{"value":"0975-7651","type":"print"},{"value":"0976-6952","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,21]]},"assertion":[{"value":"11 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"None.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}