{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:59:37Z","timestamp":1790891977337,"version":"4.1.0"},"reference-count":78,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2019,9,14]],"date-time":"2019-09-14T00:00:00Z","timestamp":1568419200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,9,14]],"date-time":"2019-09-14T00:00:00Z","timestamp":1568419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"publisher","award":["FN-2018"],"award-info":[{"award-number":["FN-2018"]}],"id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Food Sci Technol"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1007\/s13197-019-04096-8","type":"journal-article","created":{"date-parts":[[2019,9,14]],"date-time":"2019-09-14T15:02:26Z","timestamp":1568473346000},"page":"1191-1204","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Phytotherapeutic potential and pharmaceutical impact of Phoenix dactylifera (date palm): current research and future prospects"],"prefix":"10.1007","volume":"57","author":[{"given":"Abdul","family":"Qadir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6109-0885","authenticated-orcid":false,"given":"Faiyaz","family":"Shakeel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athar","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md.","family":"Faiyazuddin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,9,14]]},"reference":[{"key":"4096_CR1","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1080\/09553002.2018.1492165","volume":"94","author":"N Abdel-Magied","year":"2018","unstructured":"Abdel-Magied N, Ahmed AG, Abo Zid N (2018) Possible ameliorative effect of aqueous extract of date (Phoenix dactylifera) pits in rats exposed to gamma radiation. Int J Rad Biol 94:815\u2013824","journal-title":"Int J Rad Biol"},{"key":"4096_CR2","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1007\/s13197-018-3073-6","volume":"55","author":"NA Abdul-Hamid","year":"2018","unstructured":"Abdul-Hamid NA, Mediani A, Maulidiani M, Shadid K, Ismail IS, Abas F, Lajis NH (2018) Metabolite characterization of different palm date varieties and the correlation with their NO inhibitory activity, texture and sweetness. J Food Sci Technol 55:1541\u20131551","journal-title":"J Food Sci Technol"},{"key":"4096_CR3","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1076\/phbi.37.5.335.6051","volume":"37","author":"NM Abuharfeil","year":"1999","unstructured":"Abuharfeil NM, El Sukhon S, Msameh Y, Sallal AJ (1999) Effect of date fruits, Phoenix dactyliferia L. on the hemolytic activity of streptomycin. Pharm Biol 37:335\u2013339","journal-title":"Pharm Biol"},{"key":"4096_CR4","first-page":"421","volume":"31","author":"N Abutaha","year":"2018","unstructured":"Abutaha N, Semlali A, Baabbad A, Al-Shami M, Alanazi M, Wadaan MA (2018) Anti-proliferative and anti-inflammatory activities of entophytic Penicillium crustosum from Phoenix dactyliferia. Pak J Pharm Sci 31:421\u2013427","journal-title":"Pak J Pharm Sci"},{"key":"4096_CR5","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/0308-8146(95)00051-J","volume":"54","author":"IA Ahmed","year":"1995","unstructured":"Ahmed IA, Ahmed AWK, Robinson RK (1995) Chemical composition of date varieties as influenced by the stage of ripening. Food Chem 54:305\u2013309","journal-title":"Food Chem"},{"key":"4096_CR6","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3923\/pjn.2016.229.237","volume":"15","author":"A Ahmed","year":"2016","unstructured":"Ahmed A, Arshad MU, Saeed F, Ahmed RS, Chatha SA (2016) Nutritional probing and HPLC profiling of roasted date pit powder. Pak J Nutr 15:229\u2013237","journal-title":"Pak J Nutr"},{"key":"4096_CR7","doi-asserted-by":"publisher","first-page":"7586","DOI":"10.1021\/jf050578y","volume":"53","author":"M Al Farsi","year":"2005","unstructured":"Al Farsi M, Alasalvar C, Morris A, Baron M, Shahidi F (2005) Compositional and sensory characteristics of three native sun-dried date (Phoenix dactylifera L.) varieties grown in Oman. J Agric Food Chem 53:7586\u20137591","journal-title":"J Agric Food Chem"},{"key":"4096_CR8","doi-asserted-by":"publisher","first-page":"E13584","DOI":"10.1111\/jfpp.13584","volume":"42","author":"F Al Juhaimi","year":"2018","unstructured":"Al Juhaimi F, \u00d6zcan MM, Adiamo OQ, Alsawmahi ON, Ghafoor K, Babiker EE (2018) Effect of date varieties on physicochemical properties, fatty acid composition, tocopherol contents, and phenolic compounds of some date seed and oils. J Food Proc Preserv 42:E13584","journal-title":"J Food Proc Preserv"},{"key":"4096_CR9","doi-asserted-by":"publisher","first-page":"E845","DOI":"10.3389\/fpls.2017.00845","volume":"8","author":"RA Al-Alawi","year":"2017","unstructured":"Al-Alawi RA, Al-Mashiqri JH, Al-Madabi JSM, Al-Shihi BI, Baqi Y (2017) Date palm tree (Phoenix dactylifera L.): natural products and therapeutic options. Front Plant Sci 8:E845","journal-title":"Front Plant Sci"},{"key":"4096_CR10","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1080\/10408390701724264","volume":"48","author":"MA AlFarsi","year":"2008","unstructured":"AlFarsi MA, Lee CY (2008) Nutritional and functional properties of dates: a review. Crit Rev Food Sci Nutr 48:877\u2013887","journal-title":"Crit Rev Food Sci Nutr"},{"key":"4096_CR151","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.jclepro.2013.10.050","volume":"66","author":"FM Al-Oqla","year":"2014","unstructured":"Al-Oqla FM, Sapuan SM (2014) Natural fiber reinforced polymer composites in industrial applications: feasibility of date palm fibers for sustainable automotive industry. J Clean Prod 66:347\u2013354","journal-title":"J Clean Prod"},{"key":"4096_CR11","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/S0308-8146(98)00060-0","volume":"66","author":"BH Ali","year":"1999","unstructured":"Ali BH, Bashir AK, Al-Hadrami G (1999) Reproductive hormonal status of rats treated with date pits. Food Chem 66:437\u2013441","journal-title":"Food Chem"},{"key":"4096_CR12","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1111\/j.1365-2621.2007.01558.x","volume":"43","author":"AAA Allaith","year":"2008","unstructured":"Allaith AAA (2008) Antioxidant activity of Bahraini date palm (Phoenix dactylifera L.) fruit of various cultivars. Int J Food Sci Technol 43:1033\u20131040","journal-title":"Int J Food Sci Technol"},{"key":"4096_CR13","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/S0278-6915(02)00203-X","volume":"41","author":"AA Al-Qarawi","year":"2003","unstructured":"Al-Qarawi AA, Ali BH, Al-Mougy SA, Mousa HM (2003) Gastrointestinal transit in mice treated with various extracts of date (Phoenix dactylifera L.). Food Chem Toxicol 41:37\u201339","journal-title":"Food Chem Toxicol"},{"key":"4096_CR14","first-page":"176","volume":"3","author":"AA Al-Qarawi","year":"2004","unstructured":"Al-Qarawi AA, Mousa HM, Ali BH, Abdel-Rahman H, El-Mougy SA (2004) Protective effect of extracts from dates (Phoenix dactylifera L.) on carbon tetrachloride-induced hepatotoxicity in rats. Int J Appl Rese Vet Med 3:176\u2013180","journal-title":"Int J Appl Rese Vet Med"},{"key":"4096_CR15","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.jep.2005.01.023","volume":"98","author":"AA Al-Qarawi","year":"2005","unstructured":"Al-Qarawi AA, Abdel-Rahman H, Ali BH, Mousa HM, El-Mougy SA (2005) The ameliorative effect of dates (Phoenix dactylifera L.) on ethanol-induced gastric ulcer in rats. J Ethnopharmacol 98:313\u2013317","journal-title":"J Ethnopharmacol"},{"key":"4096_CR16","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1080\/13880200701739322","volume":"46","author":"AA Al-Qarawi","year":"2008","unstructured":"Al-Qarawi AA, Abdel-Rahman H, Mousa HM, Ali BH, El-Mougy SA (2008) Nephroprotective Action of Phoenix dactylifera in gentamicin-induced nephrotoxicity. Pharm Biol 46:227\u2013230","journal-title":"Pharm Biol"},{"key":"4096_CR17","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1080\/09637480120091982","volume":"54","author":"W Al-Shahib","year":"2003","unstructured":"Al-Shahib W, Marshall RJ (2003) The fruit of the date palm: it\u2019s possible use as the best food for the future. Int J Food Sci Nutr 54:247\u2013259","journal-title":"Int J Food Sci Nutr"},{"key":"4096_CR18","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.ijpharm.2016.02.049","volume":"504","author":"SM Alshehri","year":"2016","unstructured":"Alshehri SM, Al-Lohedan HA, Al-Farraj E, Alhokbany N, Chaudhary AA, Ahamad T (2016) Macroporous natural capsules extracted from Phoenix dactylifera L. spore and their application in oral drugs delivery. Int J Pharm 504:39\u201347","journal-title":"Int J Pharm"},{"key":"4096_CR19","doi-asserted-by":"publisher","first-page":"1744","DOI":"10.1016\/j.foodchem.2011.02.051","volume":"127","author":"EA Amira","year":"2011","unstructured":"Amira EA, Guido F, Behija SE, Manel I, Nesrine Z, Ali F, Mohamed H, Noureddine HA, Lotfi A (2011) Chemical and aroma volatile compositions of date palm (Phoenix dactylifera L.) fruits at three maturation stages. Food Chem 127:1744\u20131754","journal-title":"Food Chem"},{"key":"4096_CR20","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1080\/87559129.2010.535231","volume":"27","author":"Z Ashraf","year":"2011","unstructured":"Ashraf Z, Hamidi-Esfahani Z (2011) Date and date processing: a review. Food Rev Int 27:101\u2013133","journal-title":"Food Rev Int"},{"key":"4096_CR21","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.jff.2012.11.005","volume":"5","author":"Z Benmeddour","year":"2013","unstructured":"Benmeddour Z, Mehinagic E, Meurlay DL, Louaileche H (2013) Phenolic composition and antioxidant capacities of ten Algerian date (Phoenix dactylifera L.) cultivars: a comparative study. J Funct Foods 5:346\u2013354","journal-title":"J Funct Foods"},{"key":"4096_CR22","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1080\/09637480903124333","volume":"60","author":"N Chaira","year":"2009","unstructured":"Chaira N, Smaali MI, Martinez-Tom\u00e9 M, Mrabet A, Murcia MA, Ferchichi A (2009) Simple phenolic composition, flavonoid contents and antioxidant capacities in water\u2013methanol extracts of Tunisian common date cultivars (Phoenix dactylifera L.). Int J Food Sci Nutr 60:316\u2013329","journal-title":"Int J Food Sci Nutr"},{"key":"4096_CR23","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.sjbs.2012.12.004","volume":"20","author":"M Chandrasekaran","year":"2013","unstructured":"Chandrasekaran M, Bahkali AH (2013) Valorization of date palm (Phoenix dactylifera) fruit processing by-products and wastes using bioprocess technology\u2014review. Saudi J Biol Sci 20:105\u2013120","journal-title":"Saudi J Biol Sci"},{"key":"4096_CR24","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.jff.2017.01.033","volume":"31","author":"R Di Cagno","year":"2017","unstructured":"Di Cagno R, Filannino P, Cavoski I, Lanera A, Mamdouh BM, Gobbetti M (2017) Bioprocessing technology to exploit organic palm date (Phoenix dactylifera L. cultivar Siwi) fruit as a functional dietary supplement. J Funct Foods 31:9\u201319","journal-title":"J Funct Foods"},{"key":"4096_CR25","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.jff.2014.04.018","volume":"9","author":"A El Arem","year":"2014","unstructured":"El Arem A, Ghrairi F, Lahouar L, Thouri A, Saafi EB, Ayed A, Zekri M, Ferjani H, Haouas Z, Zakhama A, Achour L (2014) Hepatoprotective activity of date fruit extracts against dichloroacetic acid-induced liver damage in rats. J Funct Foods 9:119\u2013130","journal-title":"J Funct Foods"},{"key":"4096_CR26","first-page":"791","volume":"32","author":"AF El Fouhil","year":"2011","unstructured":"El Fouhil AF, Ahmed AM, Darwish HH, Atteya M, Al-Roalle AH (2011) An extract from date seeds having a hypoglycemic effect. Is it safe to use? Saudi Med J 32:791\u2013796","journal-title":"Saudi Med J"},{"key":"4096_CR27","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.pmpp.2010.06.008","volume":"74","author":"C El Modafar","year":"2010","unstructured":"El Modafar C (2010) Mechanism of date palm resistance to Bayoud disease: current state of knowledge and research prospects. Physiol Mol Plant Pathol 74:287\u2013294","journal-title":"Physiol Mol Plant Pathol"},{"key":"4096_CR28","first-page":"E2","volume":"1","author":"AH El-Far","year":"2016","unstructured":"El-Far AH, Shaheen HM, Abdel-Daim MM, Al Jaouni SK, Mousa SA (2016) Date palm (Phoenix dactylifera): protection and remedy food. Curr Trends Nutraceuticals 1:E2","journal-title":"Curr Trends Nutraceuticals"},{"key":"4096_CR29","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/0308-8146(94)P4195-L","volume":"52","author":"EA Elgasim","year":"1995","unstructured":"Elgasim EA, Alyousif YA, Homeida AM (1995) Possible hormonal activity of date pits and flesh fed to meat animals. Food Chem 52:149\u2013150","journal-title":"Food Chem"},{"key":"4096_CR30","first-page":"1932","volume":"23","author":"M Elguerrouj","year":"2011","unstructured":"Elguerrouj M, Paquot M, Robert C, Benjouad A, Bouakka M, Hakkou A (2011) Physicochemical composition of two varieties of Moroccan palm date fruit. Asian J Chem 23:1932\u20131936","journal-title":"Asian J Chem"},{"key":"4096_CR31","first-page":"156","volume":"5","author":"SA El-Mougy","year":"1991","unstructured":"El-Mougy SA, Abdel-Aziz SA, Al-Shanawany M, Omar A (1991) The gonadotropic activity of Palmae in mature male rats. Alex J Pharm Sci 5:156\u2013159","journal-title":"Alex J Pharm Sci"},{"key":"4096_CR32","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.carbpol.2017.10.074","volume":"181","author":"ME El-Naggar","year":"2018","unstructured":"El-Naggar ME, Shaarawy S, Hebeish AA (2018) Multifunctional properties of cotton fabrics coated with in situ synthesis of zinc oxide nanoparticles capped with date seed extract. Carbohydr Polym 181:307\u2013316","journal-title":"Carbohydr Polym"},{"key":"4096_CR150","unstructured":"El-Shaarawy M, Mesallam MI, EI-Nakhal AS, Wahdan AN (1989) Studies on extraction of dates. In: Proceedings of the second symposium on date palm. King Fahad University, AI-Hassa, Saudi Arabia, pp 3\u20136"},{"key":"4096_CR33","first-page":"41","volume":"31","author":"GA El-Sharnouby","year":"2009","unstructured":"El-Sharnouby GA, Al-Eid SM, Al-Otaibi MM (2009) Utilization of enzymes in the production of liquid sugar from dates. Afr J Biochem Res 31:41\u201347","journal-title":"Afr J Biochem Res"},{"key":"4096_CR34","first-page":"E05005","volume":"8","author":"MA Fadel","year":"2006","unstructured":"Fadel MA, Kurmestegy L, Rashed M, Rashed Z (2006) Fruit color properties of different cultivars of dates (Phoenix dactylifera, L.). Int Comm Agric Eng 8:E05005","journal-title":"Int Comm Agric Eng"},{"key":"4096_CR35","first-page":"348","volume":"65","author":"M Faiyazuddin","year":"2010","unstructured":"Faiyazuddin M, Akhtar N, Akhter J, Suri S, Shakeel F, Shafiq S, Mustafa G (2010) Production, characterization, in vitro and ex vivo studies of babchi oil-encapsulated nanostructured solid lipid carriers produced by a hot aqueous titration method. Pharmazie 65:348\u2013355","journal-title":"Pharmazie"},{"key":"4096_CR36","doi-asserted-by":"publisher","first-page":"8229","DOI":"10.1007\/s00253-018-9232-x","volume":"102","author":"S Gantait","year":"2018","unstructured":"Gantait S, El-Dawayati MM, Panigrahi J, Labrooy C, Verma SK (2018) The retrospect and prospect of the applications of biotechnology in Phoenix dactylifera L. Appl Microbiol Biotechnol 102:8229\u20138259","journal-title":"Appl Microbiol Biotechnol"},{"key":"4096_CR37","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1080\/09637480802314639","volume":"60","author":"HM Habib","year":"2009","unstructured":"Habib HM, Ibrahim WH (2009) Nutritional quality evaluation of eighteen date pit varities. Int J Food Sci Nutr 60:99\u2013111","journal-title":"Int J Food Sci Nutr"},{"key":"4096_CR38","doi-asserted-by":"publisher","first-page":"1674","DOI":"10.1002\/jsfa.4368","volume":"91","author":"HM Habib","year":"2011","unstructured":"Habib HM, Ibrahim WH (2011) Effect of date seeds on oxidative damage and antioxidant status in vivo. J Sci Food Agric 91:1674\u20131679","journal-title":"J Sci Food Agric"},{"key":"4096_CR39","doi-asserted-by":"publisher","first-page":"13620","DOI":"10.3390\/molecules200813620","volume":"20","author":"I Hamad","year":"2015","unstructured":"Hamad I, AbdElgawad H, Al Jaouni S, Zinta G, Asard H, Hassan S, Hegab M, Hagagy N, Selim S (2015) Metabolic analysis of various date palm fruit (Phoenix dactylifera L.) cultivars from Saudi Arabia to assess their nutritional quality. Molecules 20:13620\u201313641","journal-title":"Molecules"},{"key":"4096_CR40","doi-asserted-by":"publisher","first-page":"208","DOI":"10.3923\/ajcn.2010.208.214","volume":"2","author":"NS Hasan","year":"2010","unstructured":"Hasan NS, Amom ZH, Nor AI, Mokhtarrudin N, Esa NM, Azlan A (2010) Nutritional composition and in vitro evaluation of the antioxidant properties of various dates extracts (Phoenix dactylifera L) from Libya. Asian J Clin Nutr 2:208\u2013214","journal-title":"Asian J Clin Nutr"},{"key":"4096_CR41","first-page":"749","volume":"34","author":"M Hashempoori","year":"2003","unstructured":"Hashempoori M, Sanei SPM, Daneshvar M (2003) Identification of date palm cultivars in Khozestan province (Shadegan). Iran J Agric Sci 34:749\u2013755","journal-title":"Iran J Agric Sci"},{"key":"4096_CR42","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/S1773-2247(11)50034-6","volume":"21","author":"A Hussain","year":"2011","unstructured":"Hussain A, Khalid SH, Qadir MI, Massud A, Ali M, Khan IU, Saleem M, Iqbal MS, Asghar S, Gul H (2011) Water uptake and drug release behaviour of methyl methacrylate-co-itaconic acid [P(MMA\/IA)] hydrogels cross-linked with methylene bisacrylamide. J Drug Deliv Sci Technol 21:249\u2013255","journal-title":"J Drug Deliv Sci Technol"},{"key":"4096_CR156","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1111\/j.1365-2621.2005.01143.x","volume":"41","author":"B Ismail","year":"2006","unstructured":"Ismail B, Haffar I, Baalbaki R, Mechref Y, Henry J (2006) Physicochemical characteristics and total quality of five date varieties grown in the United Arab Emirates. Int J Food Sci Technol 41:919\u2013926","journal-title":"Int J Food Sci Technol"},{"key":"4096_CR43","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.carbpol.2004.11.004","volume":"59","author":"O Ishurd","year":"2005","unstructured":"Ishurd O, Kennedy JF (2005) The anti-cancer activity of polysaccharide prepared from Libyan dates (Phoenix dactylifera L.). Carbohydr Polym 59:531\u2013535","journal-title":"Carbohydr Polym"},{"key":"4096_CR44","first-page":"1","volume":"15","author":"SAA Jassim","year":"2008","unstructured":"Jassim SAA, Naji MA (2008) In vitro evaluation of the antiviral activity of an extract of date palm (Phoenix dactylifera L.) pits on a pseudomonas phage. Evi Based Complement Altern Med 15:1\u20136","journal-title":"Evi Based Complement Altern Med"},{"key":"4096_CR45","doi-asserted-by":"publisher","first-page":"245","DOI":"10.3109\/1040841X.2011.576234","volume":"37","author":"F Javed","year":"2011","unstructured":"Javed F, Qadir MI, Janbaz KH, Ali M (2011) Novel drugs from marine microorganisms. Crit Rev Microbiol 37:245\u2013249","journal-title":"Crit Rev Microbiol"},{"key":"4096_CR46","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/S1773-2247(09)50085-8","volume":"19","author":"SH Khalid","year":"2009","unstructured":"Khalid SH, Qadir MI, Massud A, Ali M, Rasool MH (2009) Effect of degree of cross-linking on swelling and drug release behaviour of poly (methyl methacrylate-co-itaconic acid) [P(MMA\/IA)] hydrogels for site specific drug delivery. J Drug Deliv Sci Technol 19:413\u2013418","journal-title":"J Drug Deliv Sci Technol"},{"key":"4096_CR47","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.jfca.2018.03.005","volume":"70","author":"F Khallouki","year":"2018","unstructured":"Khallouki F, Ricarte I, Breuer A, Owen RW (2018) Characterization of phenolic compounds in mature Moroccan Medjool date palm fruits (Phoenix dactylifera) by HPLC-DAD-ESI-MS. J Food Compos Anal 70:63\u201371","journal-title":"J Food Compos Anal"},{"key":"4096_CR48","doi-asserted-by":"publisher","first-page":"E0200104","DOI":"10.1371\/journal.pone.0200104","volume":"13","author":"AL Khan","year":"2018","unstructured":"Khan AL, Asaf S, Lee IJ, Al-Harrasi A, Al-Rawahi A (2018a) First chloroplast genomics study of Phoenix dactylifera (var. Naghal and Khanezi): a comparative analysis. PLoS ONE 13:E0200104","journal-title":"PLoS ONE"},{"key":"4096_CR49","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1166\/jbn.2018.2515","volume":"14","author":"F Khan","year":"2018","unstructured":"Khan F, Aldhahri M, Hussain MA, Gauthaman K, Memic A, Abuzenadah A, Kumosani T, Barbour E, Alothmany NS, Aldhaheri RW (2018b) Encapsulation of 5-flurouracil into PLGA nanofibers and enhanced anticancer effect in combination with Ajwa-dates-extract (Phoenix dactylifera L.). J Biomed Nanotechnol 14:553\u2013563","journal-title":"J Biomed Nanotechnol"},{"key":"4096_CR50","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.biopha.2018.07.134","volume":"107","author":"TJ Khan","year":"2018","unstructured":"Khan TJ, Kuernan A, Razvi SS, Mehanna MG, Khan KA, Almulaiky YQ, Faidallah HM (2018c) In vivo evaluation of hypolipidemic and antioxidative effect of \u2018Ajwa\u2019 (Phoenix dactylifera L.) date seed-extract in high-fat diet-induced hyperlipidemic rat model. Biomed Pharmacother 107:675\u2013680","journal-title":"Biomed Pharmacother"},{"key":"4096_CR51","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/0006-291X(64)90241-4","volume":"14","author":"VP Maier","year":"1964","unstructured":"Maier VP, Metzler DM, Huber AF (1964) 3-O-Caffeoylshikimic acid (dactylifric acid) and its isomers, a new class of enzymic browning substrates. Biochem Biophys Res Commun 14:124\u2013128","journal-title":"Biochem Biophys Res Commun"},{"key":"4096_CR52","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.foodchem.2018.02.145","volume":"256","author":"I Makhlouf-Gafsi","year":"2018","unstructured":"Makhlouf-Gafsi I, Krichen F, Mansour RB, Mokni A, Sila A, Bougatef A, Blecker C, Attia H, Besbes S (2018) Ultrafiltration and thermal processing effects on Maillard reaction products and biological properties of date palm sap syrups (Phoenix dactylifera L.). Food Chem 256:397\u2013404","journal-title":"Food Chem"},{"key":"4096_CR53","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/j.foodchem.2004.02.051","volume":"89","author":"A Mansouri","year":"2005","unstructured":"Mansouri A, Embarek G, Kokkalouc E, Kefalas P (2005) Phenolic profile and antioxidant activity of the Algerian ripe date palm fruit (Phoenix dactylifera). Food Chem 89:411\u2013420","journal-title":"Food Chem"},{"key":"4096_CR54","doi-asserted-by":"publisher","first-page":"91","DOI":"10.3109\/1040841X.2010.536522","volume":"37","author":"MI Masood","year":"2011","unstructured":"Masood MI, Qadir MI, Shirazi JH, Khan IU (2011) Beneficial effects of lactic acid bacteria on human beings. Crit Rev Microbiol 37:91\u201398","journal-title":"Crit Rev Microbiol"},{"key":"4096_CR55","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.jep.2018.02.030","volume":"218","author":"MB Mirza","year":"2018","unstructured":"Mirza MB, Elkady AI, Al-Attar AM, Syed FQ, Mohammed FA, Hakeem KR (2018) Induction of apoptosis and cell cycle arrest by ethyl acetate fraction of Phoenix dactylifera L. (Ajwa dates) in prostate cancer cells. J Ethnopharmacol 218:35\u201344","journal-title":"J Ethnopharmacol"},{"key":"4096_CR56","first-page":"397","volume":"13","author":"DA Mohamed","year":"2004","unstructured":"Mohamed DA, Al-Okbi SY (2004) In vivo evaluation of antioxidant and anti-inflammatory activity of different extracts of date fruits in adjuvant arthritis. Polish J Food Nutr Sci 13:397\u2013402","journal-title":"Polish J Food Nutr Sci"},{"key":"4096_CR57","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1111\/1750-3841.14033","volume":"83","author":"IA Nehdi","year":"2018","unstructured":"Nehdi IA, Sbihi HM, Tan CP, Rashid U, Al-Resayes SI (2018) Chemical composition of date palm (Phoenix dactylifera L.) seed oil from six Saudi Arabian cultivars. J Food Sci 83:624\u2013630","journal-title":"J Food Sci"},{"key":"4096_CR58","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/S0378-8741(99)00181-6","volume":"71","author":"A Puri","year":"2000","unstructured":"Puri A, Sahai R, Singh KL, Saxena RP, Tandon JS, Saxena KC (2000) Immunostimulant activity of dry fruits and plant materials used in Indian traditional medical system for mothers after childbirth and invalids. J Ethnopharmacol 71:89\u201392","journal-title":"J Ethnopharmacol"},{"key":"4096_CR59","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.molliq.2015.11.050","volume":"214","author":"A Qadir","year":"2016","unstructured":"Qadir A, Faiyazuddin M, Hussain MT, Alshammari T, Shakeel F (2016) Critical steps and energetics involved in a successful development of a stable nanoemulsion. J Mol Liq 214:7\u201318","journal-title":"J Mol Liq"},{"key":"4096_CR60","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/s13596-017-0257-y","volume":"17","author":"A Qadir","year":"2017","unstructured":"Qadir A, Satya PS, Akhtar J, Athar A, Arif M (2017) Phytochemical and GC-MS analysis of Saudi Arabian Ajwa variety of date seed oil and extracts obtained by the slow pyrolysis method. Orien Pharm Exp Med 17:81\u201387","journal-title":"Orien Pharm Exp Med"},{"key":"4096_CR61","first-page":"1","volume":"3","author":"AR Ragab","year":"2013","unstructured":"Ragab AR, Elkablawy MA, Sheik BY, Baraka HN (2013) Antioxidant and tissue-protective studies on Ajwa extract: dates from Al Madinah Al-Monwarah, Saudia Arabia. J Environ Anal Toxicol 3:1\u20138","journal-title":"J Environ Anal Toxicol"},{"key":"4096_CR62","first-page":"511","volume":"7","author":"S Rahimi","year":"2017","unstructured":"Rahimi S, Alaei H, Reisi P, Zolfaghari B, Siahmard Z, Pourshanazari A (2017) Evaluation of the effect of hydro-alcoholic extract of Phoenix dactylifera on sleep and EEG. Avi J Phytomed 7:511\u2013518","journal-title":"Avi J Phytomed"},{"key":"4096_CR63","first-page":"483","volume":"7","author":"AH Rahmani","year":"2014","unstructured":"Rahmani AH, Aly SM, Ali H, Babiker AY, Srikar S, Khan AA (2014) Therapeutic effects of date fruits (Phoenix dactylifera) in the prevention of diseases via modulation of anti-inflammatory, anti-oxidant and anti-tumour activity. Int J Clin Exp Med 7:483\u2013491","journal-title":"Int J Clin Exp Med"},{"key":"4096_CR64","first-page":"16","volume":"38","author":"HR Riedel","year":"1986","unstructured":"Riedel HR (1986) Dates, where they come from and how they can be used in the confectionery industry. Kakao-und-Zucke 38:16\u201319","journal-title":"Kakao-und-Zucke"},{"key":"4096_CR65","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.etp.2010.03.002","volume":"63","author":"EB Saafi","year":"2011","unstructured":"Saafi EB, Louedi M, Elfeki A, Zakhama A, Najjar MF, Hammami M, Achour L (2011) Protective effects of date palm fruit extract (Phoenix dactylifera L.) on dimethoate induced-oxidative stress in rat liver. Exp Toxicol Pathol 63:433\u2013441","journal-title":"Exp Toxicol Pathol"},{"key":"4096_CR66","first-page":"S699","volume":"31","author":"AA Saddi","year":"2018","unstructured":"Saddi AA, Mohamed AM, Shaikh AM (2018) Prophylactic mechanisms of Cucumis melo var. flexuosus and Phoenix dactylifera fruit extracts against diabetic cardiomyopathy in streptozotocin induced diabetic rats. Pak J Pharm Sci 31:S699\u2013S707","journal-title":"Pak J Pharm Sci"},{"key":"4096_CR67","first-page":"117","volume":"17","author":"A Salah","year":"2005","unstructured":"Salah A, Al-Maiman M (2005) Effect of date palm (Phoenxi dactylifera) seed fibers on plasma lipids in rats. J King Saud Univ Agric Sci 17:117\u2013123","journal-title":"J King Saud Univ Agric Sci"},{"key":"4096_CR68","first-page":"1134","volume":"2","author":"EA Saleh","year":"2011","unstructured":"Saleh EA, Tawfik MS, Abu-Tarboush HM (2011) Phenolic contents and antioxidant activity of various date palm (Phoenix dactylifera L.) fruits from Saudi Arabia. Food Nutr Sci 2:1134\u20131141","journal-title":"Food Nutr Sci"},{"key":"4096_CR69","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.biopha.2018.05.049","volume":"104","author":"GA Salem","year":"2018","unstructured":"Salem GA, Shaban A, Diab HA, Elsaghayer WA, Mjedib MD, Hnesh AM, Sahu RP (2018) Phoenix dactylifera protects against oxidative stress and hepatic injury induced by paracetamol intoxication in rats. Biomed Pharmacother 104:366\u2013374","journal-title":"Biomed Pharmacother"},{"key":"4096_CR70","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1023\/A:1006901019786","volume":"142","author":"ZA Shraideh","year":"1998","unstructured":"Shraideh ZA, Abu-Elteen KH, Sallal AK (1998) Ultrastructural effects of date extract on Candida albicans. Mycopathol 142:119\u2013123","journal-title":"Mycopathol"},{"key":"4096_CR71","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1080\/03639045.2018.1438465","volume":"44","author":"MS Soliman","year":"2018","unstructured":"Soliman MS, Abd-Allah FI, Hussain T, Saeed NM, El-Sawy HS (2018) Date seed oil loaded niosomes: development, optimization and anti-inflammatory effect evaluation on rats. Drug Develop Ind Pharm 44:1185\u20131197","journal-title":"Drug Develop Ind Pharm"},{"key":"4096_CR72","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.jff.2017.12.064","volume":"42","author":"J Tao","year":"2018","unstructured":"Tao J, Li Y, Li S, Li HB (2018) Plant foods for the prevention and management of colon cancer. J Funct Foods 42:95\u2013110","journal-title":"J Funct Foods"},{"key":"4096_CR73","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1021\/jf010716t","volume":"50","author":"PK Vayalil","year":"2002","unstructured":"Vayalil PK (2002) Antioxidant and antimutagenic properties of aqueous extract of date fruit (Phoenix dactylifera L. Arecaceae). J Agric Food Chem 50:610\u2013617","journal-title":"J Agric Food Chem"},{"key":"4096_CR74","doi-asserted-by":"publisher","first-page":"4712","DOI":"10.1166\/asl.2017.8985","volume":"43","author":"NAA Wahab","year":"2017","unstructured":"Wahab NAA, Zulkifli NZ, Shamaan NA, Hamid NA, Zahir NNM (2017) A systematic review on the beneficial effect of date palm (Phoenix dactylifera) consumption on energy metabolism. Adv Sci Lett 43:4712\u20134716","journal-title":"Adv Sci Lett"},{"key":"4096_CR75","first-page":"29","volume-title":"Chapter II: Origin, geographical distribution and nutritional values of date palm, food and agriculture organization of the United Nations (FAO), plant production and protection","author":"A Zaid","year":"1999","unstructured":"Zaid A, de Wet PF (1999) Date palm cultivation. In: Zaid A, Arias Jim\u00e9nez EJ (eds) Chapter II: Origin, geographical distribution and nutritional values of date palm, food and agriculture organization of the United Nations (FAO), plant production and protection, vol 156., pp 29\u201344"}],"container-title":["Journal of Food Science and Technology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13197-019-04096-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13197-019-04096-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13197-019-04096-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T09:29:35Z","timestamp":1600075775000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s13197-019-04096-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,14]]},"references-count":78,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["4096"],"URL":"https:\/\/doi.org\/10.1007\/s13197-019-04096-8","relation":{},"ISSN":["0022-1155","0975-8402"],"issn-type":[{"value":"0022-1155","type":"print"},{"value":"0975-8402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,14]]},"assertion":[{"value":"21 August 2019","order":1,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 September 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 September 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}