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The antioxidant activities of the ethanol and methanol extracts were determined, with the methanol extract demonstrating higher activity, 0.370\u2009\u00b1\u20090.002\u00a0mg\/mL, compared to the ethanol extract, 0.95\u2009\u00b1\u20090.09\u00a0mg\/mL. The total phenolic content of the ethanol extract was 79.14\u2009\u00b1\u20092.30\u00a0mg GAE\/g extract DW, and its flavonoid content was 244.31\u2009\u00b1\u200912.51\u00a0mg QE\/g extract DW. The methanol extract contained a lower phenolic content of 51.50\u2009\u00b1\u20091.43\u00a0mg GAE\/g extract DW but a higher flavonoid content of 251.67\u2009\u00b1\u20096.68\u00a0mg QE\/g extract DW. The ethanol extract exhibited a superior iron chelation capacity of 8.21\u2009\u00b1\u20090.09\u00a0mg\/mL relative to the methanol extract of 6.68\u2009\u00b1\u20090.28\u00a0mg\/mL. Antimicrobial assays demonstrated that both extracts exhibited strong bactericidal and bacteriostatic effects, with MIC values ranging from &lt;\u20090.39\u00a0mg\/mL to &gt;\u2009125\u00a0mg\/mL. The highest antimicrobial activity was observed against\n                    <jats:italic>Bacillus cereus<\/jats:italic>\n                    NRRL B-3711. Phytochemical analysis identified 25 compounds in the methanol extract and 20 in the ethanol extract. Stigmasterol was the major constituent in both extracts, accounting for 26.51% in ethanol and 12.65% in methanol. Molecular docking studies of stigmasterol revealed strong binding affinities with several protein targets, including\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    Complex III2 (-8.7\u00a0kcal\/mol),\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    HipBST (-7.2\u00a0kcal\/mol), and the ribosomal subunit of\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (-7.0\u00a0kcal\/mol). These interactions highlight stigmasterol\u2019s potential role in modulating bacterial and fungal protein functions, emphasising the potential therapeutic applications of\n                    <jats:italic>B. trixago<\/jats:italic>\n                    , particularly in antimicrobial and antioxidant contexts.\n                  <\/jats:p>","DOI":"10.1007\/s13197-025-06217-y","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T00:33:52Z","timestamp":1737938032000},"page":"647-663","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Phytochemical, antioxidant, and antimicrobial properties of Bellardia trixago methanol and ethanol extracts: insights from ADMET and molecular docking approaches"],"prefix":"10.1007","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6045-0183","authenticated-orcid":false,"given":"Erdi Can","family":"Aytar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bet\u00fcl","family":"Ayd\u0131n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alper","family":"Durmaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emine Incilay","family":"Toruno\u011flu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,1,27]]},"reference":[{"key":"6217_CR1","first-page":"310","volume":"24","author":"Z Abbes","year":"2014","unstructured":"Abbes Z, El-Abed N, Amri M et al (2014) Antioxidant and antibacterial activities of the parasitic plants Orobanche Foetida and Orobanche crenata collected on faba bean in Tunisia. 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