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These mostly occur as anxiety followed by depression or in mixed state. Therefore, there is an urgent need of a safe and effective treatment, which proves its worth in this ailment. What else than a conventional food would be a better choice for a convenient therapy. Therefore, <jats:italic>Garcinia indica,<\/jats:italic> commonly known as Kokam, fruit rind has been used in the present study to investigate its antidepressant and anti-anxiety potential using forced swim test, tail suspension test, and reserpine-induced hypothermia; and elevated plus maze, hole-board test, and light dark model, respectively. <jats:italic>Garcinia indica<\/jats:italic> fruit rind given to mice with food for consecutive 14\u00a0days at 0.5, 1, and 2% w\/w significantly (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05) reduced despair behavior in forced swim test, immobility duration in tail suspension test, and also switched the hypothermia (reserpine induced) to normal temperature significantly (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). <jats:italic>Garcinia indica<\/jats:italic> significantly (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05) raised the time elapsed and count of entries in open arms of elevated plus maze, enhanced incidence of head dipping in holes of hole board along with duration of expending time in lit compartment of light dark model, exhibiting its anti-anxiety effect. <jats:italic>Garcinia indica<\/jats:italic> significantly reduced monoamine oxidase and malondialdehyde levels providing support to neuroprotective potential of fruit rind. The mechanistic study showed the participation of <jats:italic>G. indica<\/jats:italic> at \u03b1<jats:sub>1<\/jats:sub>-adrenoceptor and D<jats:sub>2<\/jats:sub>-dopamine receptor, by attenuating prazosin and sulpiride-induced increase in immobility duration. <jats:italic>Garcinia indica<\/jats:italic> fruit rind showed a significant antidepressant and anxiolytic effect while no effect on locomotor activity, i.e., no psycho-stimulation.<\/jats:p>","DOI":"10.1007\/s13205-017-0766-x","type":"journal-article","created":{"date-parts":[[2017,6,8]],"date-time":"2017-06-08T01:43:47Z","timestamp":1496886227000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Antidepressant and anxiolytic effects of Garcinia indica fruit rind via monoaminergic pathway"],"prefix":"10.1007","volume":"7","author":[{"given":"Isha","family":"Dhamija","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milind","family":"Parle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,6,8]]},"reference":[{"key":"766_CR1","doi-asserted-by":"publisher","first-page":"2531","DOI":"10.1002\/1529-0131(200111)44:11<2531::AID-ART433>3.0.CO;2-J","volume":"44","author":"RD Altman","year":"2001","unstructured":"Altman RD, Marcussen KC (2001) Effects of a ginger extract on knee pain in patients with osteoarthritis. 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