{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T08:02:57Z","timestamp":1772697777667,"version":"3.50.1"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573951"],"award-info":[{"award-number":["81573951"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["3 Biotech"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1007\/s13205-020-02225-1","type":"journal-article","created":{"date-parts":[[2020,5,4]],"date-time":"2020-05-04T17:03:47Z","timestamp":1588611827000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Bacterial diversity in the intestinal mucosa of mice fed with Asparagus extract under high-fat diet condition"],"prefix":"10.1007","volume":"10","author":[{"given":"Kangxiao","family":"Guo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sisheng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maijiao","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiying","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4406-499X","authenticated-orcid":false,"given":"Wenge","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3193-073X","authenticated-orcid":false,"given":"Zhoujin","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,5,4]]},"reference":[{"issue":"3","key":"2225_CR1","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1073\/pnas.0605374104","volume":"104","author":"F Backhed","year":"2007","unstructured":"Backhed F, Manchester JK, Semenkovich CF, Gordon JI (2007) Mechanisms underlying the resistance to diet-induced obe-sity in germ-free mice. Proc Natl Acad Sci USA 104(3):979\u2013984. https:\/\/doi.org\/10.1073\/pnas.0605374104","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"2225_CR2","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1007\/s00018-015-2083-z","volume":"73","author":"PV Bauer","year":"2016","unstructured":"Bauer PV, Hamr SC, Duca FA (2016) Regulation of energy balance by a gut-brain axis and involvement of the intestinal flora. Cell Mol Life Sci 73(4):737\u2013755. https:\/\/doi.org\/10.1007\/s00018-015-2083-z","journal-title":"Cell Mol Life Sci"},{"key":"2225_CR3","doi-asserted-by":"publisher","first-page":"900","DOI":"10.3389\/fphys.2018.00900","volume":"9","author":"ES Bliss","year":"2018","unstructured":"Bliss ES, Whiteside E (2018) The gut-brain axis, the human gut microbiota and their integration in the development of obesity. Front Physiol 9:900. https:\/\/doi.org\/10.3389\/fphys.2018.00900","journal-title":"Front Physiol"},{"issue":"7","key":"2225_CR4","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.2337\/db06-1491","volume":"56","author":"PD Cani","year":"2007","unstructured":"Cani PD, Amar J, Iglesias MA, Poggi M, Knauf C, Bastelica D (2007a) Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 56(7):1761\u20131772. https:\/\/doi.org\/10.2337\/db06-1491","journal-title":"Diabetes"},{"issue":"11","key":"2225_CR5","doi-asserted-by":"publisher","first-page":"2374","DOI":"10.1007\/s00125-007-0791-0","volume":"50","author":"PD Cani","year":"2007","unstructured":"Cani PD, Neyrinck AM, Fava F, Knauf C, Burcelin RG, Tuohy KM (2007b) Selective increases of bifidobacteria in gut microflora improve high-fat-diet-in- duced diabetes in mice through a mechanism associated with endotoxaemia. Diabetologia 50(11):2374\u20132383. https:\/\/doi.org\/10.1007\/s00125-007-0791-0","journal-title":"Diabetologia"},{"issue":"1","key":"2225_CR6","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.chom.2014.11.010","volume":"17","author":"RN Carmody","year":"2015","unstructured":"Carmody RN, Gerber GK Jr, Luevano JM, Gatti DM, Somes L, Svenson KL, Turnbaugh PJ (2015) Diet dominates host genotype in shaping the murine intestinal flora. Cell Host Microbe 17(1):72\u201384. https:\/\/doi.org\/10.1016\/j.chom.2014.11.010","journal-title":"Cell Host Microbe"},{"key":"2225_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1017\/S0029665114001657","volume":"74","author":"ES Chambers","year":"2015","unstructured":"Chambers ES, Morrison DJ, Gary F (2015) Normal of appetite and energy intake by SCFA: what are the potential underlying mechanisms. Proc Nutr Soc 74:1\u20139. https:\/\/doi.org\/10.1017\/S0029665114001657","journal-title":"Proc Nutr Soc"},{"issue":"13","key":"2225_CR8","doi-asserted-by":"publisher","first-page":"224","DOI":"10.13386\/j.issn1002-0306.2012.13.083","volume":"33","author":"XH Chen","year":"2012","unstructured":"Chen XH, Qin WD, Ma LH, Zheng YH, Bian ZY (2012) Effect of different extracting juice technologies on physicochemical characteristics and antioxidant activity of green Asparagus juice. Sci Technol Food Industry 33(13):224\u2013227. https:\/\/doi.org\/10.13386\/j.issn1002-0306.2012.13.083","journal-title":"Sci Technol Food Industry"},{"issue":"14","key":"2225_CR9","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1016\/j.jacc.2012.03.074","volume":"60","author":"SC David","year":"2012","unstructured":"David SC, Clara K, Eloi M, Nicholas MA, Kam SW (2012) Cardiovascular disease in the developing world: prevalences, patterns, and the potential of early disease detection. J Am Coll Cardiol 60(14):1207\u20131216. https:\/\/doi.org\/10.1016\/j.jacc.2012.03.074","journal-title":"J Am Coll Cardiol"},{"issue":"1\u20132","key":"2225_CR10","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.cell.2013.12.016","volume":"156","author":"VF De","year":"2014","unstructured":"De VF, Kovatcheva-Datchary P, Goncalves D, Vinera J, Zitoun C, Duchampt A (2014) Microbiota-generated metabolites promote metabolic benefits via gut-brain neural circuits. Cell 156(1\u20132):84\u201396. https:\/\/doi.org\/10.1016\/j.cell.2013.12.016","journal-title":"Cell"},{"issue":"19","key":"2225_CR11","doi-asserted-by":"publisher","first-page":"20314","DOI":"10.1074\/jbc.M312475200","volume":"279","author":"R Dentin","year":"2014","unstructured":"Dentin R, P\u00e9gorier JP, Benhamed F, Foufelle F, Ferr\u00e9 P, Fauveau V, Magnuson MA, Girard J, Postic C (2014) Hepatic glucokinase is required for the synergistic action of ChREBP and SREBP-1c on glycolytic and lipogenic gene expression. J Biol Chem 279(19):20314\u201323026. https:\/\/doi.org\/10.1074\/jbc.M312475200","journal-title":"J Biol Chem"},{"issue":"1","key":"2225_CR12","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1007\/s00018-015-2061-5","volume":"73","author":"P Gerard","year":"2016","unstructured":"Gerard P (2016) Gut microbiota and obesity. Cell Mol Life Sci 73(1):147\u2013162. https:\/\/doi.org\/10.1007\/s00018-015-2061-5","journal-title":"Cell Mol Life Sci"},{"issue":"5","key":"2225_CR13","doi-asserted-by":"publisher","first-page":"343","DOI":"10.13386\/j.issn1002-0306.2015.05.064","volume":"36","author":"YJ Guan","year":"2015","unstructured":"Guan YJ, Zhou LY, Bi JF, Yi JY, Li SR (2015) Evaluation of nutritive composition and antioxidant activity in different parts of green Asparagus. Sci Technol Food Industry 36(5):343\u2013347. https:\/\/doi.org\/10.13386\/j.issn1002-0306.2015.05.064","journal-title":"Sci Technol Food Industry"},{"issue":"4","key":"2225_CR14","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1002\/em.20546","volume":"51","author":"A Hekmatdoost","year":"2010","unstructured":"Hekmatdoost A, Feizabadi MM, Djazayery A, Mirshafiey A, Eshraghian MR, Yeganeh SM, Attene-Ramos MS, Nava GM, Muellner MG, Wagner E, Plewa MJ, Gaskins HR (2010) DNA damage and toxicogenomic analyses of hydrogen sulfide in human intestinal epithelial FHs 74 Int cells. Environ Mol Mutagen 51(4):304\u2013314. https:\/\/doi.org\/10.1002\/em.20546","journal-title":"Environ Mol Mutagen"},{"issue":"8","key":"2225_CR15","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1007\/s11886-014-0515-2","volume":"16","author":"AA Hennessy","year":"2014","unstructured":"Hennessy AA, Ross RP, Fitzgerald GF, Caplice N, Stanton C (2014) Role of the gut in modulating lipoprotein metabolism. Curr Cardiol Rep 16(8):515. https:\/\/doi.org\/10.1007\/s11886-014-0515-2","journal-title":"Curr Cardiol Rep"},{"issue":"7121","key":"2225_CR16","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1038\/nature05485","volume":"444","author":"GS Hotamisligil","year":"2006","unstructured":"Hotamisligil GS (2006) (2006) Inflammation and metabolic disorders. Nature 444(7121):860\u2013867. https:\/\/doi.org\/10.1038\/nature05485","journal-title":"Nature"},{"key":"2225_CR17","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.jfca.2015.11.004","volume":"46","author":"C Jim\u00e9nez-S\u00e1nchez","year":"2016","unstructured":"Jim\u00e9nez-S\u00e1nchez C, Lozano-S\u00e1nchez J, Rodr\u00edguez-P\u00e9rez C, Segura-Carretero A, Fern\u00e1ndez-Guti\u00e9rrez A (2016) Comprehensive, untargeted, and qualitative RP-HPLC-ESI-QTOF\/MS2 metabolite profiling of green asparagus (Asparagus officinalis). J Food Compos Anal 46:78\u201387. https:\/\/doi.org\/10.1016\/j.jfca.2015.11.004","journal-title":"J Food Compos Anal"},{"issue":"7122","key":"2225_CR18","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1038\/4441022a","volume":"444","author":"RE Ley","year":"2006","unstructured":"Ley RE, Turnbaugh PJ, Klein S, Gordon JI (2006) Microbial ecology: human gut microbes associated with obesity. Nature 444(7122):1009\u20131010. https:\/\/doi.org\/10.1038\/4441022a","journal-title":"Nature"},{"issue":"2","key":"2225_CR19","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.cyto.2008.01.006","volume":"42","author":"YC Lu","year":"2008","unstructured":"Lu YC, Yeh WC, Ohashi PS (2008) LPS \/TLR4 signal transduction pathway. Cytokine 42(2):145\u2013151. https:\/\/doi.org\/10.1016\/j.cyto.2008.01.006","journal-title":"Cytokine"},{"issue":"10","key":"2225_CR20","doi-asserted-by":"publisher","first-page":"2277","DOI":"10.2337\/dc10-0556","volume":"33","author":"G Musso","year":"2010","unstructured":"Musso G, Gambino R, Cassader M (2010) Obesity, diabetes, and intestinal flora: the hygiene hypothesis expanded ? Diabetes Care 33(10):2277\u20132284. https:\/\/doi.org\/10.2337\/dc10-0556","journal-title":"Diabetes Care"},{"issue":"6","key":"2225_CR21","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/j.cell.2010.02.029","volume":"140","author":"C Nathan","year":"2010","unstructured":"Nathan C, Ding A (2010) Nonresolving inflammation. Cell 140(6):871\u2013882. https:\/\/doi.org\/10.1016\/j.cell.2010.02.029","journal-title":"Cell"},{"key":"2225_CR22","doi-asserted-by":"publisher","first-page":"e28","DOI":"10.1038\/nutd.2011.24","volume":"2","author":"AM Neyrinck","year":"2012","unstructured":"Neyrinck AM, Van H\u00e9e VF, Piront N (2012) Wheat-derived arabinoxylan oligosac charides with prebiotic effect increase satietogenic gut pep tides and reduce metabolic endotoxemia in diet-induced obese mice. Nutr Diabetes 2:e28. https:\/\/doi.org\/10.1038\/nutd.2011.24","journal-title":"Nutr Diabetes"},{"key":"2225_CR23","doi-asserted-by":"publisher","first-page":"272","DOI":"10.13982\/j.mfst.1673-9078.2006.03.096","volume":"3","author":"B Qi","year":"2006","unstructured":"Qi B, Li LH (2006) The function and properties of dietary fibre and its application in food industry. Modern Food Sci Technol 3:272\u2013274. https:\/\/doi.org\/10.13982\/j.mfst.1673-9078.2006.03.096","journal-title":"Modern Food Sci Technol"},{"issue":"9","key":"2225_CR24","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/j.tem.2015.07.002","volume":"26","author":"M Rosenbaum","year":"2015","unstructured":"Rosenbaum M, Knight R, Leibel RL (2015) The gut microbiota in human energy homeostasis and obesity. Trends Endocrinol Metab 26(9):493\u2013501. https:\/\/doi.org\/10.1016\/j.tem.2015.07.002","journal-title":"Trends Endocrinol Metab"},{"issue":"7","key":"2225_CR25","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1016\/j.jnutbio.2013.02.009","volume":"24","author":"B Ruiz-Nunez","year":"2013","unstructured":"Ruiz-Nunez B, Pruimboom L, Dijck-Brouwer DA, Muskiet AJ (2013) Lifestyle and nutritional imbalances associated with Western diseases: causes and consequences of chronic systemic low- grade inflammation in an evolutionary context. J Nutr Bio-chem 24(7):1183\u20131201. https:\/\/doi.org\/10.1016\/j.jnutbio.2013.02.009","journal-title":"J Nutr Bio-chem"},{"issue":"3","key":"2225_CR26","doi-asserted-by":"publisher","first-page":"G227","DOI":"10.1152\/ajpgi.00267.2012","volume":"304","author":"LK Stenman","year":"2013","unstructured":"Stenman LK, Holma R, Eggert A, Korpela R (2013) A novel mechanism for gut barrier dysfunction by dietary fat: epithelial disruption by hydrophobic bile acids. Am J Physiol Gastroi-ntest Liver Physiol 304(3):G227\u2013G234. https:\/\/doi.org\/10.1152\/ajpgi.00267.2012","journal-title":"Am J Physiol Gastroi-ntest Liver Physiol"},{"issue":"5","key":"2225_CR27","doi-asserted-by":"publisher","first-page":"727","DOI":"10.3945\/jn.116.240481","volume":"147","author":"M Van","year":"2017","unstructured":"Van M, Schellekens H, Dinan TG, Cryan JF (2017) Microbiota-gut-brain axis: modulator of host metabolism and appetite. J Nutr 147(5):727\u2013745. https:\/\/doi.org\/10.3945\/jn.116.240481","journal-title":"J Nutr"},{"issue":"1","key":"2225_CR28","doi-asserted-by":"publisher","first-page":"182","DOI":"10.15889\/j.issn.1002-1302.2012.01.039","volume":"40","author":"XK Wang","year":"2012","unstructured":"Wang XK, Shi YH, Wang CZ, Chen ML, Yuan DD (2012) Comparative study on hyperlipidemia rat models with different high-fat diets. Jiangsu Agric Sci 40(1):182\u2013184. https:\/\/doi.org\/10.15889\/j.issn.1002-1302.2012.01.039","journal-title":"Jiangsu Agric Sci"},{"issue":"4975","key":"2225_CR29","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1126\/science.1698311","volume":"249","author":"SD Wright","year":"2010","unstructured":"Wright SD, Ramos RA, Tobias PS, Ulevitch RJ, Mathison JC (2010) CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 249(4975):1431\u20131433. https:\/\/doi.org\/10.1126\/science.1698311","journal-title":"Science"},{"issue":"10","key":"2225_CR30","doi-asserted-by":"publisher","first-page":"205","DOI":"10.16429\/j.1009-7848.2013.10.009","volume":"13","author":"XK Yang","year":"2013","unstructured":"Yang XK, Li HC, Zhang JC, Wu MS, Chang XD (2013) Quality analysis and antioxidant research of dietary fiber from Asparagus. J Chin Inst Food Sci Technol 13(10):205\u2013212. https:\/\/doi.org\/10.16429\/j.1009-7848.2013.10.009","journal-title":"J Chin Inst Food Sci Technol"},{"issue":"9","key":"2225_CR31","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.13344\/j.microbiol.china.2012.09.012","volume":"39","author":"A Zeng","year":"2012","unstructured":"Zeng A, Zhang HL, Tan ZJ, Cai Y, Cai GX, Zhou SN (2012) The construction of mice diarrhea model due todysbacteriosis and curative effect of ultra-micro Qiweibaizhusan. Microbiol China 39(9):1341\u20131348. https:\/\/doi.org\/10.13344\/j.microbiol.china.2012.09.012","journal-title":"Microbiol China"},{"issue":"1","key":"2225_CR32","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/s13073-016-0296-x","volume":"8","author":"LS Zhang","year":"2016","unstructured":"Zhang LS, Davies SS (2016) Microbial metabolism of dietary components to bioactive metabolites: opportunities for new therapeutic interventions. Genome Med 8(1):46. https:\/\/doi.org\/10.1186\/s13073-016-0296-x","journal-title":"Genome Med"},{"issue":"1","key":"2225_CR33","doi-asserted-by":"publisher","first-page":"74","DOI":"10.12677\/HJFNS.2020.91009","volume":"9","author":"XL Zhu","year":"2020","unstructured":"Zhu XL, Li CX, Zhang L, Zhu YD (2020) Research advance in bioactive constituents and major biological activities of Asparagus officinalis L. Hans J Food Nutr Sci 9(1):74\u201381. https:\/\/doi.org\/10.12677\/HJFNS.2020.91009","journal-title":"Hans J Food Nutr Sci"}],"container-title":["3 Biotech"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13205-020-02225-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13205-020-02225-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13205-020-02225-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T00:15:31Z","timestamp":1620087331000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13205-020-02225-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["2225"],"URL":"https:\/\/doi.org\/10.1007\/s13205-020-02225-1","relation":{},"ISSN":["2190-572X","2190-5738"],"issn-type":[{"value":"2190-572X","type":"print"},{"value":"2190-5738","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"23 January 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 April 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 May 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that there is no conflict of interests regarding the publication of this paper.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was approved by the Animal Ethics and Welfare Committee of Hunan University of Chinese Medicine.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Institutional animal care and use committee statement"}}],"article-number":"228"}}