{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:01:18Z","timestamp":1788951678190,"version":"build-2803163510"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T00:00:00Z","timestamp":1684108800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T00:00:00Z","timestamp":1684108800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100004761","name":"the Natural Science Foundation of Hunan Province","doi-asserted-by":"crossref","award":["No. 2022JJ40332"],"award-info":[{"award-number":["No. 2022JJ40332"]}],"id":[{"id":"10.13039\/501100004761","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Domestic First-class Discipline Construction Project of Chinese Medicine of Hunan University of Chinese Medicine","award":["4901-020000200207"],"award-info":[{"award-number":["4901-020000200207"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["3 Biotech"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1007\/s13205-023-03580-5","type":"journal-article","created":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T11:10:48Z","timestamp":1684149048000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Brain-bacteria-gut axis and oxidative stress mediated by intestinal mucosal microbiota might be an important mechanism for constipation in mice"],"prefix":"10.1007","volume":"13","author":[{"given":"Xin","family":"Yi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxin","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3193-073X","authenticated-orcid":false,"given":"Zhoujin","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,5,15]]},"reference":[{"issue":"5","key":"3580_CR1","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.3390\/microorganisms9051098","volume":"9","author":"JN Abuqwider","year":"2021","unstructured":"Abuqwider JN, Mauriello G, Altamimi M (2021) Akkermansia muciniphila, a new generation of beneficial microbiota in modulating obesity: A systematic review. Microorganisms 9(5):1098. https:\/\/doi.org\/10.3390\/microorganisms9051098","journal-title":"Microorganisms"},{"key":"3580_CR2","unstructured":"Bai JY, Kang LY, Zhang XF, Dong SP, Wu ZQ (2018) Discussion on LI Dong-yuan\u2019s viewpoint about spleen and stomach in Piwei Lun. China J Tradit Chin Med Pharm 33(04):1478\u20131480. https:\/\/kns.cnki.net\/kcms\/detail\/detail.aspx?FileName=BXYY201810088&DbName=CJFQ2018"},{"key":"3580_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/82_2018_104","volume":"416","author":"I Belotserkovsky","year":"2018","unstructured":"Belotserkovsky I, Sansonetti PJ (2018) Shigella and enteroinvasive Escherichia coli. Curr Top Microbiol Immunol 416:1\u201326. https:\/\/doi.org\/10.1007\/82_2018_104","journal-title":"Curr Top Microbiol Immunol"},{"issue":"1","key":"3580_CR4","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/nmeth.2276","volume":"10","author":"NA Bokulich","year":"2013","unstructured":"Bokulich NA, Subramanian S, Faith JJ, Gevers D, Gordon JI, Knight R, Mills DA, Caporaso JG (2013) Quality-filtering vastly improves diversity estimates from Illumina amplicon sequencing. Nat Methods 10(1):57\u201359. https:\/\/doi.org\/10.1038\/nmeth.2276","journal-title":"Nat Methods"},{"key":"3580_CR5","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aad7121","author":"NA Bokulich","year":"2016","unstructured":"Bokulich NA, Chung J, Battaglia T, Henderson N, Jay M, Li HL, Lieber AD, Wu F, Perez-Perez GI, Chen Y, Schweizer W, Zheng XH, Contreras M, Dominguez-Bello MG, Blaser MJ (2016) Antibiotics, birth mode, and diet shape microbiome maturation during early life. Sci Transl Med. https:\/\/doi.org\/10.1126\/scitranslmed.aad7121","journal-title":"Sci Transl Med"},{"issue":"15","key":"3580_CR6","doi-asserted-by":"publisher","first-page":"6863","DOI":"10.1039\/d1fo01008e","volume":"12","author":"GF Cai","year":"2021","unstructured":"Cai GF, Wu Y, Wusiman A, Gu PF, Mao NN, Xu SW, Zhu TY, Feng Z, Liu ZG, Wang DY (2021) Alhagi honey polysaccharides attenuate intestinal injury and immune suppression in cyclophosphamide-induced mice. Food Funct 12(15):6863\u20136877. https:\/\/doi.org\/10.1039\/d1fo01008e","journal-title":"Food Funct"},{"issue":"13","key":"3580_CR7","doi-asserted-by":"publisher","first-page":"6058","DOI":"10.1039\/d1fo00559f","volume":"12","author":"M Chai","year":"2021","unstructured":"Chai M, Wang LL, Li XP, Zhao JX, Zhang H, Wang G, Chen W (2021) Different Bifidobacterium bifidum strains change the intestinal flora composition of mice via different mechanisms to alleviate loperamide-induced constipation. Food Funct 12(13):6058\u20136069. https:\/\/doi.org\/10.1039\/d1fo00559f","journal-title":"Food Funct"},{"key":"3580_CR8","unstructured":"Chao A (1984) Nonparametric estimation of the number of classes in a population. Scand J Stat 11:265\u201370. https:\/\/www.jstor.org\/stable\/4615964"},{"key":"3580_CR12","unstructured":"Chen XT, Du WL (2019) Effects of Bufei decoction on 5-ht and SP in colon of rats with slow transit constipation. Chin J Surg Integr Tradit West Med. 25(05):664\u2013668. https:\/\/kns.cnki.net\/kcms\/detail\/detail.aspx?FileName=ZGZX201905003&DbName=CJFQ2019"},{"key":"3580_CR9","doi-asserted-by":"publisher","first-page":"46820","DOI":"10.1038\/srep46820","volume":"7","author":"SY Chen","year":"2017","unstructured":"Chen SY, Tsai CN, Lee YS, Lin CY, Huang KY, Chao HC, Lai MW, Chiu CH (2017) Corrigendum: Intestinal microbiome in children with severe and complicated acute viral gastroenteritis. Sci Rep 7:46820. https:\/\/doi.org\/10.1038\/srep46820","journal-title":"Sci Rep"},{"issue":"11","key":"3580_CR10","doi-asserted-by":"publisher","first-page":"1844","DOI":"10.1111\/jgh.14281","volume":"33","author":"YJ Chen","year":"2018","unstructured":"Chen YJ, Wu H, Wu SD, Lu N, Wang YT, Liu HN, Dong L, Liu TT, Shen XZ (2018) Parasutterella, in association with irritable bowel syndrome and intestinal chronic inflammation. J Gastroenterol Hepatol 33(11):1844\u20131852. https:\/\/doi.org\/10.1111\/jgh.14281","journal-title":"J Gastroenterol Hepatol"},{"issue":"12","key":"3580_CR11","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.3760\/cma.j.cn441530-20210921-00377","volume":"24","author":"QY Chen","year":"2021","unstructured":"Chen QY, Li N, Jiang J (2021) Relationship between chronic constipation and brain-gut microflora axis. Chin J Gastroenterol Surg 24(12):1048\u20131053. https:\/\/doi.org\/10.3760\/cma.j.cn441530-20210921-00377","journal-title":"Chin J Gastroenterol Surg"},{"issue":"2","key":"3580_CR13","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1007\/s10620-009-0934-x","volume":"55","author":"C Codling","year":"2010","unstructured":"Codling C, O\u2019Mahony L, Shanahan F, Quigley EM, Marchesi JR (2010) A molecular analysis of fecal and mucosal bacterial communities in irritable bowel syndrome. Dig Dis Sci 55(2):392\u2013397. https:\/\/doi.org\/10.1007\/s10620-009-0934-x","journal-title":"Dig Dis Sci"},{"issue":"10","key":"3580_CR14","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1038\/nrn3346","volume":"13","author":"JF Cryan","year":"2012","unstructured":"Cryan JF, Dinan TG (2012) Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nat Rev Neurosci 13(10):701\u2013712. https:\/\/doi.org\/10.1038\/nrn3346","journal-title":"Nat Rev Neurosci"},{"issue":"1","key":"3580_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/imm.12765","volume":"152","author":"GLV de Oliveira","year":"2017","unstructured":"de Oliveira GLV, Leite AZ, Higuchi BS, Gonzaga MI, Mariano VS (2017) Intestinal dysbiosis and probiotic applications in autoimmune diseases. Immunology 152(1):1\u201312. https:\/\/doi.org\/10.1111\/imm.12765","journal-title":"Immunology"},{"issue":"10","key":"3580_CR16","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1038\/nmeth.2604","volume":"10","author":"RC Edgar","year":"2013","unstructured":"Edgar RC (2013) UPARSE: highly accurate OTU sequences from microbial amplicon reads. Nat Methods 10(10):996\u2013998. https:\/\/doi.org\/10.1038\/nmeth.2604","journal-title":"Nat Methods"},{"issue":"1","key":"3580_CR17","doi-asserted-by":"publisher","first-page":"6484","DOI":"10.1080\/21655979.2021.1973356","volume":"12","author":"RB Fu","year":"2021","unstructured":"Fu RB, Li ZP, Zhou R, Li CY, Shao S, Li J (2021) The mechanism of intestinal flora dysregulation mediated by intestinal bacterial biofilm to induce constipation. Bioengineered 12(1):6484\u20136498. https:\/\/doi.org\/10.1080\/21655979.2021.1973356","journal-title":"Bioengineered"},{"issue":"1","key":"3580_CR18","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1097\/MED.0b013e32835bc703","volume":"20","author":"MD Gershon","year":"2013","unstructured":"Gershon MD (2013) 5-Hydroxytryptamine (serotonin) in the gastrointestinal tract. Curr Opin Endocrinol Diabetes Obes 20(1):14\u201321. https:\/\/doi.org\/10.1097\/MED.0b013e32835bc703","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"issue":"5","key":"3580_CR19","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.3390\/microorganisms10051020","volume":"10","author":"M Gryaznova","year":"2022","unstructured":"Gryaznova M, Dvoretskaya Y, Burakova I, Syromyatnikov M, Popov E, Kokina A, Mikhaylov E, Popov V (2022) Dynamics of changes in the gut microbiota of healthy mice fed with lactic acid Bacteria and Bifidobacteria. Microorganisms 10(5):1020. https:\/\/doi.org\/10.3390\/microorganisms10051020","journal-title":"Microorganisms"},{"key":"3580_CR20","doi-asserted-by":"publisher","first-page":"6891179","DOI":"10.1155\/2022\/6891179","volume":"2022","author":"KX Guo","year":"2022","unstructured":"Guo KX, Yan YW, Zeng CF, Shen L, He YS, Tan ZJ (2022) Study on Baohe pills regulating intestinal microecology and treating diarrhea of high-fat and high-protein diet mice. Biomed Res Int 2022:6891179. https:\/\/doi.org\/10.1155\/2022\/6891179","journal-title":"Biomed Res Int"},{"key":"3580_CR21","unstructured":"He L, Long CX, Li DD, Zhang X, Peng MJ, Tan ZJ (2017) Effects of Si Mo decoction on the abundance and functional genes of intestinal bacteria in mice with spleen-deficiency constipation. Chin J Microecol 29(02):133\u2013138. https:\/\/kns.cnki.net\/kcms\/detail\/detail.aspx?FileName=ZGWS201702003&DbName=CJFQ2017"},{"issue":"1","key":"3580_CR22","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/s40168-020-00811-2","volume":"8","author":"Y Heshiki","year":"2020","unstructured":"Heshiki Y, Vazquez-Uribe R, Li J, Ni Y, Quainoo S, Imamovic L, Li J, S\u00f8rensen M, Chow BKC, Weiss GJ, Xu A, Sommer MOA, Panagiotou G (2020) Predictable modulation of cancer treatment outcomes by the gut microbiota. Microbiome 8(1):28. https:\/\/doi.org\/10.1186\/s40168-020-00811-2","journal-title":"Microbiome"},{"key":"3580_CR23","doi-asserted-by":"publisher","unstructured":"Huang LL, Zheng T, Liu YW, Guo T, Tan ZJ (2022) Diarrheal mice induced by a high-fat and high-protein diet could be cured by Bohe pill regulating intestinal mucosal bacteria. J Food Nutrres. 10(7): 459\u2013466. https:\/\/doi.org\/10.12691\/jfnr-10-7-3","DOI":"10.12691\/jfnr-10-7-3"},{"key":"3580_CR24","doi-asserted-by":"publisher","unstructured":"Iwasaki M, Akiba Y, Kaunitz JD (2019) Recent advances in vasoactive intestinal peptide physiology and pathophysiology: focus on the gastrointestinal system. F1000Res. 8:F1000 https:\/\/doi.org\/10.12688\/f1000research.18039.1","DOI":"10.12688\/f1000research.18039.1"},{"issue":"10","key":"3580_CR25","doi-asserted-by":"publisher","first-page":"9216","DOI":"10.1039\/d0fo00865f","volume":"11","author":"JH Lan","year":"2020","unstructured":"Lan JH, Wang KL, Chen GY, Cao GT, Yang CM (2020) Effects of inulin and isomalto-oligosaccharide on diphenoxylate-induced constipation, gastrointestinal motility-related hormones, short-chain fatty acids, and the intestinal flora in rats. Food Funct 11(10):9216\u20139225. https:\/\/doi.org\/10.1039\/d0fo00865f","journal-title":"Food Funct"},{"issue":"1","key":"3580_CR26","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1186\/s12934-020-01473-3","volume":"19","author":"S Li","year":"2020","unstructured":"Li S, He Y, Zhang H, Zheng R, Xu R, Liu Q, Tang S, Ke X, Huang M (2020a) Formulation of traditional Chinese medicine and its application on intestinal flora of constipated rats. Microb Cell Fact 19(1):212. https:\/\/doi.org\/10.1186\/s12934-020-01473-3","journal-title":"Microb Cell Fact"},{"issue":"8","key":"3580_CR27","doi-asserted-by":"publisher","first-page":"4388","DOI":"10.1002\/fsn3.1736","volume":"8","author":"YY Li","year":"2020","unstructured":"Li YY, Long SQ, Liu QC, Ma H, Li JX, Wei XQ, Yuan JL, Li M, Hou BB (2020b) Gut microbiota is involved in the alleviation of loperamide-induced constipation by honey supplementation in mice. Food Sci Nutr 8(8):4388\u20134398. https:\/\/doi.org\/10.1002\/fsn3.1736","journal-title":"Food Sci Nutr"},{"key":"3580_CR30","doi-asserted-by":"publisher","DOI":"10.1007\/s13205-020-02558-x","author":"XY Li","year":"2021","unstructured":"Li XY, Peng XX, Guo KX, Tan ZJ (2021a) Bacterial diversity in intestinal mucosa of mice fed with Dendrobium officinale and high-fat diet. 3 Biotech. https:\/\/doi.org\/10.1007\/s13205-020-02558-x","journal-title":"3 Biotech"},{"issue":"3","key":"3580_CR28","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1080\/15569543.2021.1955712","volume":"41","author":"XY Li","year":"2021","unstructured":"Li XY, Wu Y, Xie GZ, Tan ZJ (2021b) Effects of chronic cadmium exposure on the structure and function of intestinal mucosal flora in mice. Toxin Rev 41(3):904\u2013917. https:\/\/doi.org\/10.1080\/15569543.2021.1955712","journal-title":"Toxin Rev"},{"key":"3580_CR31","doi-asserted-by":"publisher","first-page":"952647","DOI":"10.3389\/fnut.2022.952647","volume":"9","author":"CR Li","year":"2022","unstructured":"Li CR, Zhou K, Xiao NQ, Peng MJ, Tan ZJ (2022a) The effect of Qiweibaizhu powder crude Polysaccharide on Antibiotic-associated diarrhea mice is associated with restoring intestinal mucosal bacteria. Front Nutr. 9:952647. https:\/\/doi.org\/10.3389\/fnut.2022.952647","journal-title":"Front Nutr."},{"key":"3580_CR32","doi-asserted-by":"publisher","first-page":"957334","DOI":"10.3389\/fnut.2022.957334","volume":"9","author":"XY Li","year":"2022","unstructured":"Li XY, Deng N, Zheng T, Qiao B, Peng MJ, Xiao NQ, Tan ZJ (2022b) Importance of Dendrobium officinale in improving the adverse effects of high-fat diet on mice associated with intestinal contents microbiota. Front Nutr. 9:957334. https:\/\/doi.org\/10.3389\/fnut.2022.957334","journal-title":"Front Nutr."},{"key":"3580_CR29","doi-asserted-by":"publisher","DOI":"10.5152\/tjg.2022.211010","author":"XY Li","year":"2022","unstructured":"Li XY, Zhu JY, Wu Y, Tan ZJ (2022c) Correlation between kidney function and intestinal biological characteristics of adenine and folium sennae induced diarrhea model in mice. Turk J Gastroenterol. https:\/\/doi.org\/10.5152\/tjg.2022.211010","journal-title":"Turk J Gastroenterol"},{"key":"3580_CR33","doi-asserted-by":"publisher","first-page":"9420129","DOI":"10.1155\/2020\/9420129","volume":"2020","author":"CX Long","year":"2020","unstructured":"Long CX, Shao HQ, Luo CY, Yu R, Tan ZJ (2020) Bacterial diversity in the intestinal mucosa of dysbiosis diarrhea mice treated with Qiweibaizhu powder. Gastroenterol Res Pract 2020:9420129. https:\/\/doi.org\/10.1155\/2020\/9420129","journal-title":"Gastroenterol Res Pract"},{"key":"3580_CR34","doi-asserted-by":"publisher","first-page":"1304397","DOI":"10.1155\/2018\/1304397","volume":"2018","author":"K Ma","year":"2018","unstructured":"Ma K, Chen JY, Kuang LY, Bi JL, Cheng JR, Li F, Sun XM, Nie XL, Liu YY, Luo R, Zhao XS (2018) Qi-deficiency related increases in disease susceptibility are potentially mediated by the intestinal microbiota. Evid Based Complement Alternat Med 2018:1304397. https:\/\/doi.org\/10.1155\/2018\/1304397","journal-title":"Evid Based Complement Alternat Med"},{"key":"3580_CR35","unstructured":"Maduna TL (2017) Vasoactive intestinal peptide (VIP) controls the development of the nervous system and its functions through VPAC1 receptor signalling: lessons from microcephaly and hyperalgesia in VIP-deficient mice. Strasbourg. https:\/\/theses.fr\/2017STRAJ009"},{"issue":"1","key":"3580_CR36","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1007\/s00535-017-1384-4","volume":"53","author":"K Nishino","year":"2018","unstructured":"Nishino K, Nishida A, Inoue R, Kawada Y, Ohno M, Sakai S, Inatomi O, Bamba S, Sugimoto M, Kawahara M, Naito Y, Andoh A (2018) Analysis of endoscopic brush samples identified mucosa-associated dysbiosis in inflammatory bowel disease. J Gastroenterol 53(1):95\u2013106. https:\/\/doi.org\/10.1007\/s00535-017-1384-4","journal-title":"J Gastroenterol"},{"key":"3580_CR37","doi-asserted-by":"publisher","first-page":"113263","DOI":"10.1016\/j.biopha.2022.113263","volume":"152","author":"T Oshiro","year":"2022","unstructured":"Oshiro T, Harada Y, Kubota K, Sadatomi D, Sekine H, Nishiyama M, Fujitsuka N (2022) Associations between intestinal microbiota, fecal properties, and dietary fiber conditions: The Japanese traditional medicine Junchoto ameliorates dietary fiber deficit-induced constipation with F\/B ratio alteration in rats. Biomed Pharmacother. 152:113263. https:\/\/doi.org\/10.1016\/j.biopha.2022.113263","journal-title":"Biomed Pharmacother."},{"issue":"10","key":"3580_CR38","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1007\/s40265-020-01305-z","volume":"80","author":"J Pannemans","year":"2020","unstructured":"Pannemans J, Masuy I, Tack J (2020) Functional constipation: individualising assessment and treatment. Drugs. 80(10):947\u2013963. https:\/\/doi.org\/10.1007\/s40265-020-01305-z","journal-title":"Drugs."},{"issue":"2","key":"3580_CR39","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.jinf.2010.12.003","volume":"62","author":"JL Parker","year":"2011","unstructured":"Parker JL, Shaw JG (2011) Aeromonas spp. clinical microbiology and disease. J Infect 62(2):109\u2013118. https:\/\/doi.org\/10.1016\/j.jinf.2010.12.003","journal-title":"J Infect"},{"key":"3580_CR40","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1016\/j.biopha.2017.11.119","volume":"96","author":"XX Ren","year":"2017","unstructured":"Ren XX, Liu L, Gamallat Y, Zhang BQ, Xin Y (2017) Enteromorpha and polysaccharides from enteromorpha ameliorate loperamide-induced constipation in mice. Biomed Pharmacother 96:1075\u20131081. https:\/\/doi.org\/10.1016\/j.biopha.2017.11.119","journal-title":"Biomed Pharmacother"},{"key":"3580_CR41","doi-asserted-by":"publisher","first-page":"R60","DOI":"10.1186\/gb-2011-12-6-r60","volume":"12","author":"N Segata","year":"2011","unstructured":"Segata N, Izard J, Waldron L, Gevers D, Miropolsky L, Garrett WS, Huttenhower C (2011) Metagenomic biomarker discovery and explanation. Genome Biol 12:R60. https:\/\/doi.org\/10.1186\/gb-2011-12-6-r60","journal-title":"Genome Biol"},{"issue":"12","key":"3580_CR42","doi-asserted-by":"publisher","first-page":"2520","DOI":"10.1016\/j.jpedsurg.2019.08.038","volume":"54","author":"S Seo","year":"2019","unstructured":"Seo S, Miyake H, Alganabi M, Janssen Lok M, O\u2019Connell JS, Lee C, Li B, Pierro A (2019) Vasoactive intestinal peptide decreases inflammation and tight junction disruption in experimental necrotizing enterocolitis. J Pediatr Surg 54(12):2520\u20132523. https:\/\/doi.org\/10.1016\/j.jpedsurg.2019.08.038","journal-title":"J Pediatr Surg"},{"issue":"9","key":"3580_CR43","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1016\/j.tibtech.2015.06.011","volume":"33","author":"NR Shin","year":"2015","unstructured":"Shin NR, Whon TW, Bae JW (2015) Proteobacteria: microbial signature of dysbiosis in gut microbiota. Trends Biotechnol 33(9):496\u2013503. https:\/\/doi.org\/10.1016\/j.tibtech.2015.06.011","journal-title":"Trends Biotechnol"},{"key":"3580_CR44","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1038\/163688a0","volume":"163","author":"EH Simpson","year":"1949","unstructured":"Simpson EH (1949) Measurement of diversity. Nature 163:688. https:\/\/doi.org\/10.1038\/163688a0","journal-title":"Nature"},{"issue":"11","key":"3580_CR45","doi-asserted-by":"publisher","first-page":"1715","DOI":"10.3390\/microorganisms8111715","volume":"8","author":"S Stojanov","year":"2020","unstructured":"Stojanov S, Berlec A, \u0160trukelj B (2020) The Influence of probiotics on the Firmicutes\/Bacteroidetes ratio in the treatment of obesity and inflammatory bowel disease. Microorganisms 8(11):1715. https:\/\/doi.org\/10.3390\/microorganisms8111715","journal-title":"Microorganisms"},{"key":"3580_CR46","unstructured":"Su HJ, Chen GZ, Xie JY (2018) Treatment of functional constipation from theory of spleen and stomach. Liaoning J Tradit Chin Med 45(12):2548\u20132550. https:\/\/kns.cnki.net\/kcms\/detail\/detail.aspx?FileName=LNZY201812027&DbName=DKFX2018"},{"issue":"5","key":"3580_CR47","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1007\/s00284-019-01859-6","volume":"77","author":"RP Wang","year":"2020","unstructured":"Wang RP, Pan X, Xu YJ (2020a) Altered intestinal microbiota composition associated with enteritis in yellow seahorses hippocampus kuda (Bleeker, 1852). Curr Microbiol 77(5):730\u2013737. https:\/\/doi.org\/10.1007\/s00284-019-01859-6","journal-title":"Curr Microbiol"},{"key":"3580_CR49","unstructured":"Wang WF, Liu FL, Xia XT, Wang WS, Teng GF, Wang T, Tu QR (2020b) Effects of Zhizhu Pills on expression of PI3K and AKT in colon of mice with slow transmission and constipation of spleen deficiency syndrome. China J Tradit Chin Med Pharm 35(06):2824\u20132828. https:\/\/kns.cnki.net\/kcms\/detail\/detail.aspx?FileName=BXYY2020b06033&DbName=CJFQ2020b"},{"issue":"3","key":"3580_CR48","doi-asserted-by":"publisher","first-page":"1628","DOI":"10.1039\/d1fo03896f","volume":"13","author":"LY Wang","year":"2022","unstructured":"Wang LY, Wang LL, Tian PJ, Wang BT, Cui SM, Zhao JX, Zhang H, Qian L, Wang Q, Chen W, Wang G (2022) A randomised, double-blind, placebo-controlled trial of Bifidobacterium bifidum CCFM16 for manipulation of the gut microbiota and relief from chronic constipation. Food Funct 13(3):1628\u20131640. https:\/\/doi.org\/10.1039\/d1fo03896f","journal-title":"Food Funct"},{"key":"3580_CR50","unstructured":"Wu H, Yi K, Tang XG (2022a) Effect of Yangxue Runchang Prescription on clinical efficacy symptom score and oxidative stress index for patients with blood-deficiency chronic functional constipation. J Sichuan Tradit Chin Med 40(02):101\u2013105. https:\/\/kns.cnki.net\/kcms\/detail\/detail.aspx?FileName=SCZY2022a02032&DbName=DKFX2022a"},{"key":"3580_CR51","doi-asserted-by":"publisher","unstructured":"Wu Y, Peng XX, Li XY, Li DD, Tan ZJ, Yu R (2022b) Sex hormones influences intestinal microbiota composition in mice. Front Microbiol 13:964847. https:\/\/doi.org\/10.3389\/fmicb.2022.964847","DOI":"10.3389\/fmicb.2022.964847"},{"key":"3580_CR52","doi-asserted-by":"publisher","first-page":"813757","DOI":"10.3389\/fnut.2021.813757","volume":"8","author":"Z Wu","year":"2022","unstructured":"Wu Z, Cheng W, Wang Z, Feng S, Zou H, Tan X, Yang Y, Wang Y, Zhang H, Dong M, Xiao Y, Tao S, Wei H (2022) Intestinal microbiota and serum metabolic profile responded to two nutritional different diets in mice. Front Nutr. 8:813757. https:\/\/doi.org\/10.3389\/fnut.2021.813757","journal-title":"Front Nutr."},{"key":"3580_CR53","unstructured":"Xia XT, Liu FL, Wang WF, Wang WS, Chen YB (2020) Effects of Zhizhu pills on intestinal conduction function in slow transit constipation model mice with spleen deficiency syndrome. China J Tradit Chin Med Pharm 61(19):1725\u20131730. https:\/\/kns.cnki.net\/kcms\/detail\/detail.aspx?FileName=ZZYZ202019016&DbName=CJFQ2020"},{"key":"3580_CR54","unstructured":"Xiang CY, Liu J, Zhang YZ, Xu JX (2019) Effect of Modified simotang on adult functional constipation and intestinal neurotransmitter. Chin J Exp Tradit Med Formulae. 25(02):150\u2013155. https:\/\/kns.cnki.net\/kcms\/detail\/detail.aspx?FileName=ZSFX201902023&DbName=DKFX2019"},{"issue":"10","key":"3580_CR55","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.3390\/ph14101036","volume":"14","author":"C Yu","year":"2021","unstructured":"Yu C, Peng Y, Huang C, Hsieh YW, Hou YC, Lin SP (2021a) Folium sennae increased the bioavailability of methotrexate through modulation on MRP 2 and BCRP. Pharmaceuticals (Basel) 14(10):1036. https:\/\/doi.org\/10.3390\/ph14101036","journal-title":"Pharmaceuticals (Basel)"},{"key":"3580_CR56","unstructured":"Yu ZZ, Tan ZJ, Xiao NQ (2021b) Effects of Dendrobium Officinalis on intestinal morphology and number of intestinal immune cells in mice with spleen-deficiency and constipation. J Food Saf Qual 12(08):3224\u20133228. https:\/\/kns.cnki.net\/kcms\/detail\/detail.aspx?FileName=SPAJ2021b08037&DbName=CJFQ2021b"},{"key":"3580_CR57","unstructured":"Yu ZY, Hao LY, Li ZY, Sun JH, Chen HY, Huo HR, Li XQ, Shan ZC, Li HM (2022) Correlation between slow transit constipation and spleen deficiency, and gut microbiota: a pilot study. J Tradit Chin Med 42(3):353\u2013363. https:\/\/kns.cnki.net\/kcms\/detail\/detail.aspx?FileName=ZYYW202203018&DbName=CJFQ2022"},{"issue":"11","key":"3580_CR58","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0224730","volume":"14","author":"A Zeng","year":"2019","unstructured":"Zeng A, Peng MJ, Liu HZ, Guo ZH, Xu J, Wang SP, He L, Tan ZJ (2019) Effects of Debaryomyces hansenii treatment on intestinal mucosa microecology in mice with antibiotic-associated diarrhea. PLoS One. 14(11):e0224730. https:\/\/doi.org\/10.1371\/journal.pone.0224730","journal-title":"PLoS One."},{"issue":"7","key":"3580_CR59","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.1039\/c8bm00466h","volume":"6","author":"R Zhang","year":"2018","unstructured":"Zhang R, Leeper CN, Wang X, White TA, Ulery BD (2018) Immunomodulatory vasoactive intestinal peptide amphiphile micelles. Biomater Sci 6(7):1717\u20131722. https:\/\/doi.org\/10.1039\/c8bm00466h","journal-title":"Biomater Sci"},{"issue":"8","key":"3580_CR60","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1007\/s13205-020-02368-1","volume":"10","author":"CY Zhang","year":"2020","unstructured":"Zhang CY, Shao HQ, Peng XX, Liu TH, Tan ZJ (2020) Microbiotal characteristics colonized in intestinal mucosa of mice with diarrhoea and repeated stress. 3 Biotech. 10(8):372. https:\/\/doi.org\/10.1007\/s13205-020-02368-1","journal-title":"3 Biotech."},{"key":"3580_CR61","unstructured":"Zhao Y, Li P, Wu YY, Liu LJ, Deng SG, Zhao RZ (2022) Effects of Vinegar-baked bupleuri radix polysaccharides with different molecular weight on delayedtype hypersensitivity mice. Tradit Chin Drug Res Clin Pharmacol 33(07):902\u2013907. https:\/\/kns.cnki.net\/kcms\/detail\/detail.aspx?FileName=ZYXY202207007&DbName=CJFQ2022"},{"key":"3580_CR62","doi-asserted-by":"publisher","first-page":"1004845","DOI":"10.3389\/fcimb.2022.1004845","volume":"12","author":"K Zhou","year":"2022","unstructured":"Zhou K, Deng N, Yi X, Cai Y, Peng MJ, Xiao NQ (2022) Baohe pill decoction for diarrhea induced by high-fat and high-protein diet is associated with the structure of lactase-producing bacterial community. Front Cell Infect Microbiol 12:1004845. https:\/\/doi.org\/10.3389\/fcimb.2022.1004845","journal-title":"Front Cell Infect Microbiol"},{"issue":"11","key":"3580_CR63","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.11817\/j.issn.1672-7347.2016.11.010","volume":"41","author":"YX Zhou","year":"2016","unstructured":"Zhou YX, Wang YJ, Zhang H, Yan SG, Wang B, Xie P (2016) Effect of vasoactive intestinal peptide on defecation and VIP-cAMP-PKA-AQP3 signaling pathway in rats with constipation. J Cent South Univ Med Sci 41(11):1175\u20131180. https:\/\/doi.org\/10.11817\/j.issn.1672-7347.2016.11.010","journal-title":"J Cent South Univ Med Sci"},{"key":"3580_CR64","unstructured":"Zou Y, Zheng XB, Dai SX, Ye QL, Wu Dan (2009) Establishment of spleen deficiency model in mice. Beijing J Tradit Chin Med 28(01):60\u201362. https:\/\/kns.cnki.net\/kcms\/detail\/detail.aspx?FileName=BJZO200901033&DbName=CJFQ2009"}],"container-title":["3 Biotech"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13205-023-03580-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13205-023-03580-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13205-023-03580-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,3]],"date-time":"2023-06-03T00:28:46Z","timestamp":1685752126000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13205-023-03580-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,15]]},"references-count":64,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["3580"],"URL":"https:\/\/doi.org\/10.1007\/s13205-023-03580-5","relation":{},"ISSN":["2190-572X","2190-5738"],"issn-type":[{"value":"2190-572X","type":"print"},{"value":"2190-5738","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,15]]},"assertion":[{"value":"26 December 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 April 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 May 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"We declare that we do not have any commercial or associative interest that represents a conflict of interest in connection with the work submitted.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Animal experiments were conducted under animal protocols approved by the Animal Ethics and Welfare Committee of the Hunan University of Chinese Medicine (protocol number: LL2022052505). All animal work was carried out following accordance with the guidelines of the Institutional Animal Care and Use Committee of Hunan University of Chinese Medicine. This study was carried out in compliance with the ARRIVE guidelines.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The datasets presented in this study can be found in online repositories. The names of the repository\/repositories and accession number(s) can be found below:\n                      \n                      , PRJNA878625.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Additional requirements"}}],"article-number":"192"}}