{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T23:41:09Z","timestamp":1772840469143,"version":"3.50.1"},"reference-count":68,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Indian Council of Medical Research Senior Research Fellowship","award":["45\/16\/2022\/TOXI\/BMS"],"award-info":[{"award-number":["45\/16\/2022\/TOXI\/BMS"]}]},{"name":"Science and Engineering Research Board, Government of India","award":["EMR\/2016\/003548"],"award-info":[{"award-number":["EMR\/2016\/003548"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["3 Biotech"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1007\/s13205-023-03584-1","type":"journal-article","created":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T08:02:28Z","timestamp":1683187348000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Adriamycin downregulates the expression of KLF4 in cardiomyocytes in vitro and contributes to impaired cardiac energy metabolism in Adriamycin-induced cardiomyopathy"],"prefix":"10.1007","volume":"13","author":[{"given":"Uma Priya","family":"Mohan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. B. Tirupathi","family":"Pichiah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2857-4877","authenticated-orcid":false,"given":"Sankarganesh","family":"Arunachalam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,5,4]]},"reference":[{"issue":"1","key":"3584_CR1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.22235","volume":"33","author":"IST Akthar","year":"2019","unstructured":"Akthar IST, Pichiah PBT, Arunachalam S, Raja S (2019a) Adriamycin inhibits embryonic development in zebrafish through downregulation of Kruppel-like factor4. J Biochem Mol Toxicol 33(1):e22235","journal-title":"J Biochem Mol Toxicol"},{"issue":"1","key":"3584_CR2","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.22235","volume":"33","author":"ISTST Akthar","year":"2019","unstructured":"Akthar ISTST, Pichiah PBTBT, Arunachalam S, Raja S (2019b) Adriamycin inhibits embryonic development in zebrafish through downregulation of Kruppel-like factor4. J Biochem Mol Toxicol 33(1):e22235. https:\/\/doi.org\/10.1002\/jbt.22235","journal-title":"J Biochem Mol Toxicol"},{"issue":"1","key":"3584_CR3","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.cmet.2007.06.007","volume":"6","author":"WA Alaynick","year":"2007","unstructured":"Alaynick WA, Kondo RP, Xie W, He W, Dufour CR, Downes M, Jonker JW, Giles W, Naviaux RK, Giguere V (2007) ERR\u03b3 directs and maintains the transition to oxidative metabolism in the postnatal heart. Cell Metab 6(1):13\u201324","journal-title":"Cell Metab"},{"key":"3584_CR4","unstructured":"Alexieva B, Sainova I, Pavlova V (2014) Insights into mechanisms of doxorubicin cardiotoxicity"},{"issue":"4","key":"3584_CR5","doi-asserted-by":"publisher","first-page":"H1489","DOI":"10.1152\/ajpheart.00278.2006","volume":"291","author":"D An","year":"2006","unstructured":"An D, Rodrigues B (2006) Role of changes in cardiac metabolism in development of diabetic cardiomyopathy. Am J Physiol Heart Circulatory Physiol 291(4):H1489\u2013H1506","journal-title":"Am J Physiol Heart Circulatory Physiol"},{"issue":"4","key":"3584_CR6","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.cmet.2005.03.002","volume":"1","author":"Z Arany","year":"2005","unstructured":"Arany Z, He H, Lin J, Hoyer K, Handschin C, Toka O, Ahmad F, Matsui T, Chin S, Wu P-H (2005) Transcriptional coactivator PGC-1\u03b1 controls the energy state and contractile function of cardiac muscle. Cell Metab 1(4):259\u2013271","journal-title":"Cell Metab"},{"issue":"7","key":"3584_CR7","doi-asserted-by":"publisher","first-page":"540","DOI":"10.3109\/15376516.2012.692110","volume":"22","author":"S Arunachalam","year":"2012","unstructured":"Arunachalam S, Kim SY, Kim MS, Yi HK, Yun BS, Lee DY, Hwang PH (2012a) Adriamycin inhibits adipogenesis through the modulation of PPAR\u03b3 and restoration of adriamycin-mediated inhibition of adipogenesis by PPAR\u03b3 over-expression. Toxicol Mech Methods 22(7):540\u2013546. https:\/\/doi.org\/10.3109\/15376516.2012.692110","journal-title":"Toxicol Mech Methods"},{"issue":"7","key":"3584_CR8","doi-asserted-by":"publisher","first-page":"540","DOI":"10.3109\/15376516.2012.692110","volume":"22","author":"S Arunachalam","year":"2012","unstructured":"Arunachalam S, Kim S-YS-Y, Kim M-SM-S, Yi H-K, Yun B-SB-S, Lee D-YD-Y, Hwang P-HP-H (2012b) Adriamycin inhibits adipogenesis through the modulation of PPAR\u03b3 and restoration of Adriamycin-mediated inhibition of adipogenesis by PPAR\u03b3 over-expression. Toxicol Mech Methods 22(7):540\u2013546. https:\/\/doi.org\/10.3109\/15376516.2012.692110","journal-title":"Toxicol Mech Methods"},{"key":"3584_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2012.11.019","author":"S Arunachalam","year":"2013","unstructured":"Arunachalam S, Tirupathi Pichiah PB, Achiraman S (2013) Doxorubicin treatment inhibits PPAR\u03b3 and may induce lipotoxicity by mimicking a type 2 diabetes-like condition in rodent models. FEBS Lett. https:\/\/doi.org\/10.1016\/j.febslet.2012.11.019","journal-title":"FEBS Lett"},{"issue":"6","key":"3584_CR10","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/S1050-1738(00)00077-3","volume":"10","author":"PM Barger","year":"2000","unstructured":"Barger PM, Kelly DP (2000) PPAR signaling in the control of cardiac energy metabolism. Trends Cardiovasc Med 10(6):238\u2013245","journal-title":"Trends Cardiovasc Med"},{"key":"3584_CR11","doi-asserted-by":"publisher","first-page":"644","DOI":"10.5604\/17322693.1206541","volume":"70","author":"T Bednarski","year":"2016","unstructured":"Bednarski T, Pyrkowska A, Opasi\u0144ska A, Dobrzy\u0144 P (2016) Regulation of cardiac metabolism and function by lipogenic factors. Postepy Hig Med Dosw(online) 70:644\u2013653","journal-title":"Postepy Hig Med Dosw(online)"},{"issue":"4","key":"3584_CR12","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.cmet.2008.02.001","volume":"7","author":"K Birsoy","year":"2008","unstructured":"Birsoy K, Chen Z, Friedman J (2008) Transcriptional regulation of adipogenesis by KLF4. Cell Metab 7(4):339\u2013347","journal-title":"Cell Metab"},{"issue":"12","key":"3584_CR13","first-page":"3930","volume":"117","author":"EM Burkart","year":"2007","unstructured":"Burkart EM, Sambandam N, Han X, Gross RW, Courtois M, Gierasch CM, Shoghi K, Welch MJ, Kelly DP (2007) Nuclear receptors PPAR\u03b2\/\u03b4 and PPAR\u03b1 direct distinct metabolic regulatory programs in the mouse heart. J Clin Investig 117(12):3930\u20133939","journal-title":"J Clin Investig"},{"issue":"6","key":"3584_CR14","doi-asserted-by":"publisher","first-page":"4098","DOI":"10.1074\/jbc.M106054200","volume":"277","author":"FM Campbell","year":"2002","unstructured":"Campbell FM, Kozak R, Wagner A, Altarejos JY, Dyck JRB, Belke DD, Severson DL, Kelly DP, Lopaschuk GD (2002) A role for peroxisome proliferator-activated receptor \u03b1 (PPAR\u03b1) in the control of cardiac malonyl-CoA levels reduced fatty acid oxidation rates and increased glucose oxidation rates in the hearts of mice lacking PPAR\u03b1 are associated with higher concentrat. J Biol Chem 277(6):4098\u20134103","journal-title":"J Biol Chem"},{"issue":"2","key":"3584_CR15","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/S0887-8994(99)00133-2","volume":"22","author":"BT Darras","year":"2000","unstructured":"Darras BT, Friedman NR (2000) Metabolic myopathies: a clinical approach; part I. Pediatr Neurol 22(2):87\u201397","journal-title":"Pediatr Neurol"},{"issue":"2","key":"3584_CR16","doi-asserted-by":"publisher","first-page":"193","DOI":"10.2174\/157489006777442441","volume":"1","author":"SK Das","year":"2006","unstructured":"Das SK, Chakrabarti R (2006) Role of PPAR in cardiovascular diseases. Recent Pat Cardiovasc Drug Discovery 1(2):193\u2013209. https:\/\/doi.org\/10.2174\/157489006777442441","journal-title":"Recent Pat Cardiovasc Drug Discovery"},{"issue":"7","key":"3584_CR17","doi-asserted-by":"publisher","first-page":"3060","DOI":"10.1016\/S0021-9258(17)35746-0","volume":"261","author":"KJ Davies","year":"1986","unstructured":"Davies KJ, Doroshow JH (1986) Redox cycling of anthracyclines by cardiac mitochondria. I. Anthracycline radical formation by NADH dehydrogenase. J Biol Chem 261(7):3060\u20133067","journal-title":"J Biol Chem"},{"issue":"8","key":"3584_CR18","doi-asserted-by":"publisher","first-page":"4043","DOI":"10.1128\/MCB.16.8.4043","volume":"16","author":"DL Disch","year":"1996","unstructured":"Disch DL, Rader TA, Cresci S, Leone TC, Barger PM, Vega R, Wood PA, Kelly DP (1996) Transcriptional control of a nuclear gene encoding a mitochondrial fatty acid oxidation enzyme in transgenic mice: role for nuclear receptors in cardiac and brown adipose expression. Mol Cell Biol 16(8):4043\u20134051","journal-title":"Mol Cell Biol"},{"issue":"6","key":"3584_CR19","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1161\/CIRCRESAHA.113.300376","volume":"113","author":"T Doenst","year":"2013","unstructured":"Doenst T, Nguyen TD, Abel ED (2013) Cardiac metabolism in heart failure: implications beyond ATP production. Circ Res 113(6):709\u2013724","journal-title":"Circ Res"},{"issue":"7","key":"3584_CR20","doi-asserted-by":"publisher","first-page":"3068","DOI":"10.1016\/S0021-9258(17)35747-2","volume":"261","author":"JH Doroshow","year":"1986","unstructured":"Doroshow JH, Davies KJ (1986) Redox cycling of anthracyclines by cardiac mitochondria. II. Formation of superoxide anion, hydrogen peroxide, and hydroxyl radical. J Biol Chem 261(7):3068\u20133074","journal-title":"J Biol Chem"},{"issue":"4","key":"3584_CR21","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1161\/01.RES.0000179226.34112.6d","volume":"97","author":"SZ Duan","year":"2005","unstructured":"Duan SZ, Ivashchenko CY, Russell MW, Milstone DS, Mortensen RM (2005) Cardiomyocyte-specific knockout and agonist of peroxisome proliferator\u2013activated receptor-\u03b3 both induce cardiac hypertrophy in mice. Circ Res 97(4):372\u2013379","journal-title":"Circ Res"},{"key":"3584_CR22","doi-asserted-by":"crossref","unstructured":"Duan SZ, Ivashchenko CY, Usher MG, Mortensen RM (2008) PPAR-[gamma] in the Cardiovascular System. PPAR Research, 2008","DOI":"10.1155\/2008\/745804"},{"issue":"5","key":"3584_CR23","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.cmet.2007.03.007","volume":"5","author":"CR Dufour","year":"2007","unstructured":"Dufour CR, Wilson BJ, Huss JM, Kelly DP, Alaynick WA, Downes M, Evans RM, Blanchette M, Giguere V (2007) Genome-wide orchestration of cardiac functions by the orphan nuclear receptors ERR\u03b1 and \u03b3. Cell Metab 5(5):345\u2013356","journal-title":"Cell Metab"},{"issue":"2","key":"3584_CR24","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.cardiores.2006.08.023","volume":"73","author":"BN Finck","year":"2007","unstructured":"Finck BN (2007) The PPAR regulatory system in cardiac physiology and disease. Cardiovasc Res 73(2):269\u2013277. https:\/\/doi.org\/10.1016\/j.cardiores.2006.08.023","journal-title":"Cardiovasc Res"},{"issue":"19","key":"3584_CR25","doi-asserted-by":"publisher","first-page":"2540","DOI":"10.1161\/CIRCULATIONAHA.107.670588","volume":"115","author":"BN Finck","year":"2007","unstructured":"Finck BN, Kelly DP (2007) Peroxisome proliferator\u2013activated receptor \u03b3 coactivator-1 (PGC-1) regulatory cascade in cardiac physiology and disease. Circulation 115(19):2540\u20132548","journal-title":"Circulation"},{"key":"3584_CR26","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1161\/01.RES.0000060700.55247.7C","volume":"92","author":"AJ Gilde","year":"2003","unstructured":"Gilde AJ (2003) van der Lee KA, Willemsen PH, Chinetti G, van der Leij FR, van der Vusse GJ, Staels B, and van Bilsen M. Peroxisome Proliferator-Activated Receptor (PPAR) Alpha and PPARbeta\/Delta, but Not PPARgamma, Modulate the Expression of Genes Involved in Cardiac Lipid Metabolism. Circ Res 92:518\u2013524","journal-title":"Circ Res"},{"issue":"4","key":"3584_CR27","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1046\/j.1365-201X.2003.01161.x","volume":"178","author":"AJ Gilde","year":"2003","unstructured":"Gilde AJ, Van Bilsen M (2003) Peroxisome proliferator-activated receptors (PPARS): regulators of gene expression in heart and skeletal muscle. Acta Physiol Scand 178(4):425\u2013434","journal-title":"Acta Physiol Scand"},{"issue":"2","key":"3584_CR28","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.cardiores.2004.06.030","volume":"64","author":"S Goffart","year":"2004","unstructured":"Goffart S, von Kleist-Retzow J-C, Wiesner RJ (2004) Regulation of mitochondrial proliferation in the heart: power-plant failure contributes to cardiac failure in hypertrophy. Cardiovasc Res 64(2):198\u2013207","journal-title":"Cardiovasc Res"},{"issue":"23","key":"3584_CR29","doi-asserted-by":"publisher","first-page":"11012","DOI":"10.1073\/pnas.91.23.11012","volume":"91","author":"T Gulick","year":"1994","unstructured":"Gulick T, Cresci S, Caira T, Moore DD, Kelly DP (1994) The peroxisome proliferator-activated receptor regulates mitochondrial fatty acid oxidative enzyme gene expression. Proc Natl Acad Sci 91(23):11012\u201311016","journal-title":"Proc Natl Acad Sci"},{"issue":"5","key":"3584_CR30","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1016\/S0006-291X(02)02753-5","volume":"299","author":"M Hentschke","year":"2002","unstructured":"Hentschke M, S\u00fcsens U, Borgmeyer U (2002) PGC-1 and PERC, coactivators of the estrogen receptor-related receptor \u03b3. Biochem Biophys Res Commun 299(5):872\u2013879","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"3584_CR31","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1042\/BJ20020754","volume":"366","author":"MJ Holness","year":"2002","unstructured":"Holness MJ, Bulmer K, Gibbons GF, Sugden MC (2002) Up-regulation of pyruvate dehydrogenase kinase isoform 4 (PDK4) protein expression in oxidative skeletal muscle does not require the obligatory participation of peroxisome-proliferator-activated receptor \u03b1 (PPAR\u03b1). Biochem J 366(3):839\u2013846. https:\/\/doi.org\/10.1042\/BJ20020754","journal-title":"Biochem J"},{"issue":"6","key":"3584_CR32","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1161\/01.RES.0000141774.29937.e3","volume":"95","author":"JM Huss","year":"2004","unstructured":"Huss JM, Kelly DP (2004) Nuclear receptor signaling and cardiac energetics. Circ Res 95(6):568\u2013578","journal-title":"Circ Res"},{"issue":"43","key":"3584_CR33","doi-asserted-by":"publisher","first-page":"40265","DOI":"10.1074\/jbc.M206324200","volume":"277","author":"JM Huss","year":"2002","unstructured":"Huss JM, Kopp RP, Kelly DP (2002) Peroxisome proliferator-activated receptor coactivator-1\u03b1 (PGC-1\u03b1) coactivates the cardiac-enriched nuclear receptors estrogen-related receptor-\u03b1 and-\u03b3: identification of novel leucine-rich interaction motif within PGC-1\u03b1. J Biol Chem 277(43):40265\u201340274","journal-title":"J Biol Chem"},{"issue":"1","key":"3584_CR34","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.cmet.2007.06.005","volume":"6","author":"JM Huss","year":"2007","unstructured":"Huss JM, Imahashi K, Dufour CR, Weinheimer CJ, Courtois M, Kovacs A, Gigu\u00e8re V, Murphy E, Kelly DP (2007) The nuclear receptor ERR\u03b1 is required for the bioenergetic and functional adaptation to cardiac pressure overload. Cell Metab 6(1):25\u201337","journal-title":"Cell Metab"},{"issue":"6","key":"3584_CR35","doi-asserted-by":"publisher","first-page":"2160","DOI":"10.1073\/pnas.90.6.2160","volume":"90","author":"H Keller","year":"1993","unstructured":"Keller H, Dreyer C, Medin J, Mahfoudi A, Ozato K, Wahli W (1993) Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor-retinoid X receptor heterodimers. Proc Natl Acad Sci 90(6):2160\u20132164","journal-title":"Proc Natl Acad Sci"},{"issue":"11","key":"3584_CR36","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1172\/JCI6223","volume":"103","author":"S Kersten","year":"1999","unstructured":"Kersten S, Seydoux J, Peters JM, Gonzalez FJ, Desvergne B, Wahli W (1999) Peroxisome proliferator\u2013activated receptor \u03b1 mediates the adaptive response to fasting. J Clin Investig 103(11):1489\u20131498","journal-title":"J Clin Investig"},{"issue":"6","key":"3584_CR37","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1016\/j.bbamcr.2011.03.002","volume":"1813","author":"AV Kuznetsov","year":"2011","unstructured":"Kuznetsov AV, Margreiter R, Amberger A, Saks V, Grimm M (2011) Changes in mitochondrial redox state, membrane potential and calcium precede mitochondrial dysfunction in doxorubicin-induced cell death. Biochimica Et Biophysica Acta (BBA)-Molecular Cell Research 1813(6):1144\u20131152","journal-title":"Biochimica Et Biophysica Acta (BBA)-Molecular Cell Research"},{"issue":"3","key":"3584_CR38","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1172\/JCI27989","volume":"116","author":"P Lefebvre","year":"2006","unstructured":"Lefebvre P, Chinetti G, Fruchart J-C, Staels B (2006) Sorting out the roles of PPAR\u03b1 in energy metabolism and vascular homeostasis. J Clin Investig 116(3):571\u2013580","journal-title":"J Clin Investig"},{"issue":"13","key":"3584_CR39","doi-asserted-by":"publisher","first-page":"7473","DOI":"10.1073\/pnas.96.13.7473","volume":"96","author":"TC Leone","year":"1999","unstructured":"Leone TC, Weinheimer CJ, Kelly DP (1999) A critical role for the peroxisome proliferator-activated receptor \u03b1 (PPAR\u03b1) in the cellular fasting response: the PPAR\u03b1-null mouse as a model of fatty acid oxidation disorders. Proc Natl Acad Sci 96(13):7473\u20137478","journal-title":"Proc Natl Acad Sci"},{"issue":"6","key":"3584_CR40","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1006\/jmcc.2001.1378","volume":"33","author":"EJ Lesnefsky","year":"2001","unstructured":"Lesnefsky EJ, Moghaddas S, Tandler B, Kerner J, Hoppel CL (2001) Mitochondrial dysfunction in cardiac disease: ischemia\u2013reperfusion, aging, and heart failure. J Mol Cell Cardiol 33(6):1065\u20131089","journal-title":"J Mol Cell Cardiol"},{"issue":"9","key":"3584_CR41","doi-asserted-by":"publisher","first-page":"3461","DOI":"10.1172\/JCI79964","volume":"125","author":"X Liao","year":"2015","unstructured":"Liao X, Zhang R, Lu Y, Prosdocimo DA, Sangwung P, Zhang L, Zhou G, Anand P, Lai L, Leone TC (2015) Kruppel-like factor 4 is critical for transcriptional control of cardiac mitochondrial homeostasis. J Clin Investig 125(9):3461\u20133476","journal-title":"J Clin Investig"},{"key":"3584_CR42","doi-asserted-by":"publisher","first-page":"1602","DOI":"10.3389\/fcell.2020.625089","volume":"8","author":"H Liao","year":"2021","unstructured":"Liao H, Qi Y, Ye Y, Yue P, Zhang D, Li Y (2021) Mechanotranduction pathways in the regulation of mitochondrial homeostasis in cardiomyocytes. Front Cell Dev Biol 8:1602","journal-title":"Front Cell Dev Biol"},{"issue":"1","key":"3584_CR43","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1152\/physrev.00015.2009","volume":"90","author":"GD Lopaschuk","year":"2010","unstructured":"Lopaschuk GD, Ussher JR, Folmes CDL, Jaswal JS, Stanley WC (2010) Myocardial fatty acid metabolism in health and disease. Physiol Rev 90(1):207\u2013258","journal-title":"Physiol Rev"},{"issue":"6","key":"3584_CR44","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1016\/j.yjmcc.2008.03.021","volume":"44","author":"JA Madrazo","year":"2008","unstructured":"Madrazo JA, Kelly DP (2008) The PPAR trio: regulators of myocardial energy metabolism in health and disease. J Mol Cell Cardiol 44(6):968\u2013975","journal-title":"J Mol Cell Cardiol"},{"issue":"4","key":"3584_CR45","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1161\/CIRCRESAHA.114.302562","volume":"114","author":"OJ Martin","year":"2014","unstructured":"Martin OJ, Lai L, Soundarapandian MM, Leone TC, Zorzano A, Keller MP, Attie AD, Muoio DM, Kelly DP (2014) A role for peroxisome proliferator-activated receptor \u03b3 coactivator-1 in the control of mitochondrial dynamics during postnatal cardiac growth. Circ Res 114(4):626\u2013636","journal-title":"Circ Res"},{"key":"3584_CR46","unstructured":"Mohan UP, Kunjiappan S, Arunachalam S (2021a) Disruption of glycolysis, TCA cycle, respiratory chain, calcium and iron homeostasis in doxorubicin induced cardiomyopathy-an in-silico approach"},{"issue":"1","key":"3584_CR47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s13205-020-02530-9","volume":"11","author":"UP Mohan","year":"2021","unstructured":"Mohan UP, Kunjiappan S, Pichiah PBT, Arunachalam S (2021b) Adriamycin inhibits glycolysis through downregulation of key enzymes in Saccharomyces cerevisiae. 3 Biotech 11(1):1\u201313","journal-title":"3 Biotech"},{"key":"3584_CR48","doi-asserted-by":"publisher","DOI":"10.1002\/JAT.4374","author":"UP Mohan","year":"2022","unstructured":"Mohan UP, Pichiah PBT, Kunjiappan S, Arunachalam S (2022) A hypothesis concerning the role of PPAR family on cardiac energetics in Adriamycin-induced cardiomyopathy. J Appl Toxicol. https:\/\/doi.org\/10.1002\/JAT.4374","journal-title":"J Appl Toxicol"},{"key":"3584_CR49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41569-021-00569-6","volume":"18","author":"D Montaigne","year":"2021","unstructured":"Montaigne D, Butruille L, Staels B (2021) PPAR control of metabolism and cardiovascular functions. Nat Rev Cardiol 18:1\u201315","journal-title":"Nat Rev Cardiol"},{"issue":"1","key":"3584_CR50","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1146\/annurev.biochem.70.1.313","volume":"70","author":"CO Pabo","year":"2001","unstructured":"Pabo CO, Peisach E, Grant RA (2001) Design and selection of novel Cys2His2 zinc finger proteins. Annu Rev Biochem 70(1):313\u2013340","journal-title":"Annu Rev Biochem"},{"issue":"9","key":"3584_CR51","doi-asserted-by":"publisher","first-page":"2514","DOI":"10.2337\/diabetes.54.9.2514","volume":"54","author":"S-Y Park","year":"2005","unstructured":"Park S-Y, Cho Y-R, Finck BN, Kim H-J, Higashimori T, Hong E-G, Lee M-K, Danton C, Deshmukh S, Cline GW (2005) Cardiac-specific overexpression of peroxisome proliferator\u2013activated receptor-\u03b1 causes insulin resistance in heart and liver. Diabetes 54(9):2514\u20132524","journal-title":"Diabetes"},{"issue":"3","key":"3584_CR52","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1007\/s00424-007-0297-0","volume":"455","author":"C Pellieux","year":"2007","unstructured":"Pellieux C, Montessuit C, Papageorgiou I, Lerch R (2007) Inactivation of peroxisome proliferator-activated receptor isoforms \u03b1, \u03b2\/\u03b4, and \u03b3 mediate distinct facets of hypertrophic transformation of adult cardiac myocytes. Pfl\u00fcgers Arch Eur J Physiol 455(3):443\u2013454","journal-title":"Pfl\u00fcgers Arch Eur J Physiol"},{"issue":"12","key":"3584_CR53","doi-asserted-by":"publisher","first-page":"2802","DOI":"10.1002\/ijc.24683","volume":"125","author":"J Rageul","year":"2009","unstructured":"Rageul J, Mottier S, Jarry A, Shah Y, Th\u00e9oleyre S, Masson D, Gonzalez FJ, Laboisse CL, Denis MG (2009) KLF4-dependent, PPAR\u03b3-induced expression of GPA33 in colon cancer cell lines. Int J Cancer 125(12):2802\u20132809","journal-title":"Int J Cancer"},{"key":"3584_CR54","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2017.10.043","author":"K Renu","year":"2018","unstructured":"Renu K, Abilash VG, Tirupathi Pichiah PB, Arunachalam S (2018) Molecular mechanism of doxorubicin-induced cardiomyopathy\u2014an update. Eur J Pharmacol. https:\/\/doi.org\/10.1016\/j.ejphar.2017.10.043","journal-title":"Eur J Pharmacol"},{"key":"3584_CR55","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.ejphar.2017.10.043","volume":"818","author":"K Renu","year":"2018","unstructured":"Renu K, Abilash VG, Tirupathi Pichiah PB, Arunachalam S (2018) Molecular mechanism of doxorubicin-induced cardiomyopathy\u2013an update. Eur J Pharmacol 818:241\u2013253","journal-title":"Eur J Pharmacol"},{"key":"3584_CR56","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.ejphar.2018.11.018","volume":"843","author":"K Renu","year":"2019","unstructured":"Renu K, Sruthy KBB, Parthiban S, Sugunapriyadharshini S, George A, Tirupathi Pichiah PB, Suman S, Abilash VGG, Arunachalam S, Tirupathi Pichiah PB, Suman S, Abilash VGG, Arunachalam S (2019) Elevated lipolysis in adipose tissue by doxorubicin via PPAR\u03b1 activation associated with hepatic steatosis and insulin resistance. Eur J Pharmacol 843:162\u2013176. https:\/\/doi.org\/10.1016\/j.ejphar.2018.11.018","journal-title":"Eur J Pharmacol"},{"issue":"17","key":"3584_CR57","first-page":"274","volume":"108","author":"M Schupp","year":"2003","unstructured":"Schupp M, Kintscher U, Pregla R, Dietrich T, Unger T, Regitz-Zagrosek V (2003) Cardiac PPARalpha expression in patients with dilated cardiomyopathy. Circulation 108(17):274","journal-title":"Circulation"},{"issue":"10","key":"3584_CR58","doi-asserted-by":"publisher","first-page":"2791","DOI":"10.1172\/JCI30335","volume":"117","author":"N-H Son","year":"2007","unstructured":"Son N-H, Park T-S, Yamashita H, Yokoyama M, Huggins LA, Okajima K, Homma S, Szabolcs MJ, Huang L-S, Goldberg IJ (2007) Cardiomyocyte expression of PPAR\u03b3 leads to cardiac dysfunction in mice. J Clin Investig 117(10):2791\u20132801","journal-title":"J Clin Investig"},{"issue":"2","key":"3584_CR59","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1021\/acs.chemrestox.9b00093","volume":"33","author":"S Thabassum Akhtar Iqbal","year":"2020","unstructured":"Thabassum Akhtar Iqbal S, Tirupathi Pichiah PB, Raja S, Arunachalam S (2020) Paeonol reverses adriamycin induced cardiac pathological remodeling through notch1 signaling reactivation in H9c2 cells and adult zebrafish heart. Chem Res Toxicol 33(2):312\u2013323. https:\/\/doi.org\/10.1021\/acs.chemrestox.9b00093","journal-title":"Chem Res Toxicol"},{"key":"3584_CR60","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2011.10.027","author":"PB Tirupathi Pichiah","year":"2012","unstructured":"Tirupathi Pichiah PB, Sankarganesh A, Kalaiselvi S, Indirani K, Kamalakkannan S, SankarGanesh D, Hwang PH, Cha YS, Achiraman S (2012) Adriamycin induced spermatogenesis defect is due to the reduction in epididymal adipose tissue mass: a possible hypothesis. Med Hypotheses. https:\/\/doi.org\/10.1016\/j.mehy.2011.10.027","journal-title":"Med Hypotheses"},{"key":"3584_CR61","doi-asserted-by":"publisher","first-page":"811","DOI":"10.3389\/fphar.2020.00811","volume":"11","author":"J Tu","year":"2020","unstructured":"Tu J, Zhu S, Li B, Xu G, Luo X, Jiang L, Yan X, Zhang R, Chen C (2020) Gegen qinlian decoction coordinately regulates PPAR\u03b3 and PPAR\u03b1 to improve glucose and lipid homeostasis in diabetic rats and insulin resistance 3T3-L1 adipocytes. Front Pharmacol 11:811","journal-title":"Front Pharmacol"},{"issue":"3","key":"3584_CR62","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.pharmthera.2009.12.001","volume":"125","author":"K-D Wagner","year":"2010","unstructured":"Wagner K-D, Wagner N (2010) Peroxisome proliferator-activated receptor beta\/delta (PPAR\u03b2\/\u03b4) acts as regulator of metabolism linked to multiple cellular functions. Pharmacol Ther 125(3):423\u2013435","journal-title":"Pharmacol Ther"},{"issue":"2","key":"3584_CR63","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/S0092-8674(03)00269-1","volume":"113","author":"Y-X Wang","year":"2003","unstructured":"Wang Y-X, Lee C-H, Tiep S, Ruth TY, Ham J, Kang H, Evans RM (2003) Peroxisome-proliferator-activated receptor \u03b4 activates fat metabolism to prevent obesity. Cell 113(2):159\u2013170","journal-title":"Cell"},{"issue":"24","key":"3584_CR64","doi-asserted-by":"publisher","first-page":"10684","DOI":"10.1128\/MCB.25.24.10684-10694.2005","volume":"25","author":"AR Wende","year":"2005","unstructured":"Wende AR, Huss JM, Schaeffer PJ, Giguere V, Kelly DP (2005) PGC-1\u03b1 coactivates PDK4 gene expression via the orphan nuclear receptor ERR\u03b1: a mechanism for transcriptional control of muscle glucose metabolism. Mol Cell Biol 25(24):10684\u201310694","journal-title":"Mol Cell Biol"},{"issue":"9","key":"3584_CR65","first-page":"2435","volume":"7","author":"Y Yang","year":"2014","unstructured":"Yang Y, Zhang H, Li X, Yang T, Jiang Q (2014) Effects of PPAR\u03b1\/PGC-1\u03b1 on the myocardial energy metabolism during heart failure in the doxorubicin induced dilated cardiomyopathy in mice. Int J Clin Exp Med 7(9):2435","journal-title":"Int J Clin Exp Med"},{"issue":"4","key":"3584_CR66","doi-asserted-by":"publisher","first-page":"918","DOI":"10.7150\/jca.27226","volume":"10","author":"C Yang","year":"2019","unstructured":"Yang C, Wang S, Ruan H, Li B, Cheng Z, He J, Zuo Q, Yu C, Wang H, Lv Y (2019) Downregulation of PDK4 increases lipogenesis and associates with poor prognosis in hepatocellular carcinoma. J Cancer 10(4):918","journal-title":"J Cancer"},{"issue":"2","key":"3584_CR67","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1093\/toxsci\/kfw006","volume":"150","author":"H Yuan","year":"2016","unstructured":"Yuan H, Zhang Q, Guo J, Zhang T, Zhao J, Li J, White A, Carmichael PL, Westmoreland C, Peng S (2016) A PGC-1\u03b1-mediated transcriptional network maintains mitochondrial redox and bioenergetic homeostasis against doxorubicin-induced toxicity in human cardiomyocytes: implementation of TT21C. Toxicol Sci 150(2):400\u2013417","journal-title":"Toxicol Sci"},{"issue":"21","key":"3584_CR68","doi-asserted-by":"publisher","first-page":"8284","DOI":"10.1158\/0008-5472.CAN-09-1345","volume":"69","author":"Q Zhou","year":"2009","unstructured":"Zhou Q, Hong Y, Zhan Q, Shen Y, Liu Z (2009) Role for Kr\u00fcppel-like factor 4 in determining the outcome of p53 response to DNA damage. Can Res 69(21):8284\u20138292","journal-title":"Can Res"}],"container-title":["3 Biotech"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13205-023-03584-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13205-023-03584-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13205-023-03584-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T05:33:39Z","timestamp":1683783219000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13205-023-03584-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":68,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["3584"],"URL":"https:\/\/doi.org\/10.1007\/s13205-023-03584-1","relation":{},"ISSN":["2190-572X","2190-5738"],"issn-type":[{"value":"2190-572X","type":"print"},{"value":"2190-5738","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"13 December 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 April 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 May 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing financial interest as well as no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This article does not contain any studies with human participants performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"For this type of study, formal consent is not required.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}],"article-number":"162"}}