{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T10:29:08Z","timestamp":1786357748188,"version":"build-2736575974"},"reference-count":75,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100007496","name":"Biomedical Laboratory Research and Development, VA Office of Research and Development","doi-asserted-by":"publisher","award":["1 I01 BX006849-01"],"award-info":[{"award-number":["1 I01 BX006849-01"]}],"id":[{"id":"10.13039\/100007496","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007496","name":"Biomedical Laboratory Research and Development, VA Office of Research and Development","doi-asserted-by":"publisher","award":["1I21BX006418-01A1"],"award-info":[{"award-number":["1I21BX006418-01A1"]}],"id":[{"id":"10.13039\/100007496","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK102043"],"award-info":[{"award-number":["DK102043"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["3 Biotech"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1007\/s13205-026-04975-w","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T22:45:19Z","timestamp":1784069119000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Modulation of Ca2+ signaling by tulsi (holy basil) extract in renal epithelial wound-healing model"],"prefix":"10.1007","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0074-8831","authenticated-orcid":false,"given":"Onyebuchi C.","family":"Ukaeje","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3461-2844","authenticated-orcid":false,"given":"Samuel","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2364-8945","authenticated-orcid":false,"given":"Bidhan C.","family":"Bandyopadhyay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,15]]},"reference":[{"issue":"22","key":"4975_CR1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27227712","volume":"27","author":"MZ Ahmad","year":"2022","unstructured":"Ahmad MZ, Alasiri AS, Ahmad J et al (2022) Green synthesis of titanium dioxide nanoparticles using Ocimum sanctum leaf extract: in vitro characterization and its healing efficacy in diabetic wounds. Molecules 27(22):7712. https:\/\/doi.org\/10.3390\/molecules27227712","journal-title":"Molecules"},{"key":"4975_CR2","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1016\/j.biopha.2018.07.080","volume":"106","author":"S Ahmed","year":"2018","unstructured":"Ahmed S, Hasan MM, Khan H, Mahmood ZA, Patel S (2018) The mechanistic insight of polyphenols in calcium oxalate urolithiasis mitigation. Biomed Pharmacother 106:1292\u20131299. https:\/\/doi.org\/10.1016\/j.biopha.2018.07.080","journal-title":"Biomed Pharmacother"},{"key":"4975_CR3","doi-asserted-by":"publisher","first-page":"3068365","DOI":"10.1155\/2018\/3068365","volume":"2018","author":"T Alelign","year":"2018","unstructured":"Alelign T, Petros B (2018) Kidney Stone Disease: An Update on Current Concepts. Adv Urol 2018:3068365. https:\/\/doi.org\/10.1155\/2018\/3068365","journal-title":"Adv Urol"},{"issue":"4","key":"4975_CR4","doi-asserted-by":"publisher","DOI":"10.3390\/app12042107","volume":"12","author":"A Antony","year":"2022","unstructured":"Antony A, Farid M (2022) Effect of temperatures on polyphenols during extraction. Appl Sci (Basel) 12(4):2107. https:\/\/doi.org\/10.3390\/app12042107","journal-title":"Appl Sci (Basel)"},{"key":"4975_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111762","volume":"140","author":"E Awuah Boadi","year":"2021","unstructured":"Awuah Boadi E, Shin S, Bandyopadhyay BC (2021) Tannic acid attenuates vascular calcification-induced proximal tubular cells damage through paracrine signaling. Biomed Pharmacother 140:111762. https:\/\/doi.org\/10.1016\/j.biopha.2021.111762","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"4975_CR6","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1039\/d1tb01213d","volume":"10","author":"E Awuah Boadi","year":"2021","unstructured":"Awuah Boadi E, Shin S, Gombedza F, Bandyopadhyay BC (2021) Differential biomolecular recognition by synthetic vs. biologically-derived components in the stone-forming process using 3D microfluidics. J Mater Chem B 10(1):34\u201346. https:\/\/doi.org\/10.1039\/d1tb01213d","journal-title":"J Mater Chem B"},{"issue":"6","key":"4975_CR7","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1016\/j.molcel.2017.05.028","volume":"66","author":"R Bagur","year":"2017","unstructured":"Bagur R, Hajn\u00f3czky G (2017) Intracellular Ca2\u2009+\u2009sensing: its role in calcium homeostasis and signaling. Mol Cell 66(6):780\u2013788. https:\/\/doi.org\/10.1016\/j.molcel.2017.05.028","journal-title":"Mol Cell"},{"key":"4975_CR8","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/35036035","volume":"1","author":"MJ Berridge","year":"2000","unstructured":"Berridge MJ, Lipp P, Bootman MD (2000) The versatility and universality of calcium signalling. Nat Rev Mol Cell Biol 1:11\u201321","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"22","key":"4975_CR9","doi-asserted-by":"publisher","DOI":"10.3390\/plants11223160","volume":"11","author":"SK Bhamra","year":"2022","unstructured":"Bhamra SK, Heinrich M, Johnson MRD, Howard C, Slater A (2022) The cultural and commercial value of Tulsi (Ocimum tenuiflorum L.): multidisciplinary approaches focusing on species authentication. Plants (Basel) 11(22):3160. https:\/\/doi.org\/10.3390\/plants11223160","journal-title":"Plants (Basel)"},{"issue":"7","key":"4975_CR10","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1097\/CAD.0b013e328361aca1","volume":"24","author":"P Bhattacharyya","year":"2013","unstructured":"Bhattacharyya P, Bishayee A (2013) Ocimum sanctum Linn. (Tulsi): an ethnomedicinal plant for the prevention and treatment of cancer. Anti-cancer Drugs 24(7):659\u2013666. https:\/\/doi.org\/10.1097\/CAD.0b013e328361aca1","journal-title":"Anti-cancer Drugs"},{"issue":"11","key":"4975_CR11","doi-asserted-by":"publisher","first-page":"6636","DOI":"10.1021\/acs.cgd.9b01036","volume":"19","author":"EA Boadi","year":"2019","unstructured":"Boadi EA, Deems NJ, Raub CB, Bandyopadhyay BC (2019) Matting calcium crystals by melamine improves stabilization and prevents dissolution. Cryst Growth Des 19(11):6636\u20136648. https:\/\/doi.org\/10.1021\/acs.cgd.9b01036","journal-title":"Cryst Growth Des"},{"key":"4975_CR12","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/978-1-62703-290-2_7","volume":"979","author":"FK Chan","year":"2013","unstructured":"Chan FK, Moriwaki K, De Rosa MJ (2013) Detection of necrosis by release of lactate dehydrogenase activity. Methods Mol Biol 979:65\u201370. https:\/\/doi.org\/10.1007\/978-1-62703-290-2_7","journal-title":"Methods Mol Biol"},{"key":"4975_CR13","doi-asserted-by":"publisher","DOI":"10.1007\/s11101-024-09992-2","author":"A Chatterjee","year":"2024","unstructured":"Chatterjee A, Sarkar B (2024) Polyphenols and terpenoids derived from Ocimum species as prospective hepatoprotective drug leads: a comprehensive mechanistic review. Phytochem Rev. https:\/\/doi.org\/10.1007\/s11101-024-09992-2","journal-title":"Phytochem Rev"},{"issue":"5","key":"4975_CR14","doi-asserted-by":"publisher","first-page":"477","DOI":"10.3109\/13880209.2010.523832","volume":"49","author":"M Chatterjee","year":"2011","unstructured":"Chatterjee M, Verma P, Maurya R, Palit G (2011) Evaluation of ethanol leaf extract of Ocimum sanctum in experimental models of anxiety and depression. Pharm Biol 49(5):477\u2013483. https:\/\/doi.org\/10.3109\/13880209.2010.523832","journal-title":"Pharm Biol"},{"issue":"10","key":"4975_CR15","doi-asserted-by":"publisher","first-page":"3852","DOI":"10.1007\/s13197-020-04417-2","volume":"57","author":"A Chaudhary","year":"2020","unstructured":"Chaudhary A, Sharma S, Mittal A, Gupta S, Dua A (2020) Phytochemical and antioxidant profiling of Ocimum sanctum. J Food Sci Technol 57(10):3852\u20133863. https:\/\/doi.org\/10.1007\/s13197-020-04417-2","journal-title":"J Food Sci Technol"},{"issue":"10","key":"4975_CR16","doi-asserted-by":"publisher","first-page":"3852","DOI":"10.1007\/s13197-020-04417-2","volume":"57","author":"A Chaudhary","year":"2020","unstructured":"Chaudhary A, Sharma S, Mittal A, Gupta S, Dua A (2020) Phytochemical and antioxidant profiling of Ocimum sanctum. J Food Sci Technol 57(10):3852\u20133863. https:\/\/doi.org\/10.1007\/s13197-020-04417-2","journal-title":"J Food Sci Technol"},{"issue":"3","key":"4975_CR18","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1159\/000332153","volume":"20","author":"CE Clark","year":"2012","unstructured":"Clark CE, Nourse CC, Cooper HM (2012) The tangled web of non-canonical Wnt signalling in neural migration. Neurosignals 20(3):202\u2013220. https:\/\/doi.org\/10.1159\/000332153","journal-title":"Neurosignals"},{"issue":"9","key":"4975_CR19","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1038\/nrneph.2016.101","volume":"12","author":"FL Coe","year":"2016","unstructured":"Coe FL, Worcester EM, Evan AP (2016) Idiopathic hypercalciuria and formation of calcium renal stones. Nat Rev Nephrol 12(9):519\u2013533. https:\/\/doi.org\/10.1038\/nrneph.2016.101","journal-title":"Nat Rev Nephrol"},{"issue":"4","key":"4975_CR20","doi-asserted-by":"publisher","first-page":"251","DOI":"10.4103\/0975-9476.146554","volume":"5","author":"MM Cohen","year":"2014","unstructured":"Cohen MM (2014) Tulsi - Ocimum sanctum: A herb for all reasons. J Ayurveda Integr Med 5(4):251. https:\/\/doi.org\/10.4103\/0975-9476.146554","journal-title":"J Ayurveda Integr Med"},{"issue":"4","key":"4975_CR21","doi-asserted-by":"publisher","first-page":"251","DOI":"10.4103\/0975-9476.146554","volume":"5","author":"MM Cohen","year":"2014","unstructured":"Cohen MM (2014) Tulsi\u2014Ocimum sanctum: a herb for all reasons. J Ayurveda Integr Med 5(4):251\u2013259. https:\/\/doi.org\/10.4103\/0975-9476.146554","journal-title":"J Ayurveda Integr Med"},{"issue":"10","key":"4975_CR22","doi-asserted-by":"publisher","first-page":"2407","DOI":"10.3390\/ijms20102407","volume":"20","author":"F Collin","year":"2019","unstructured":"Collin F (2019) Chemical basis of reactive oxygen species reactivity and involvement in neurodegenerative diseases. Int J Mol Sci 20(10):2407. https:\/\/doi.org\/10.3390\/ijms20102407","journal-title":"Int J Mol Sci"},{"issue":"8","key":"4975_CR23","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.molmed.2009.06.005","volume":"15","author":"LR Coulthard","year":"2009","unstructured":"Coulthard LR, White DE, Jones DL, McDermott MF, Burchill SA (2009) p38(MAPK): stress responses from molecular mechanisms to therapeutics. Trends Mol Med 15(8):369\u2013379. https:\/\/doi.org\/10.1016\/j.molmed.2009.06.005","journal-title":"Trends Mol Med"},{"issue":"4","key":"4975_CR24","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1097\/MNH.0000000000000229","volume":"25","author":"T Ermer","year":"2016","unstructured":"Ermer T, Eckardt KU, Aronson PS, Knauf F (2016) Oxalate, inflammasome, and progression of kidney disease. Curr Opin Nephrol Hypertens 25(4):363\u2013371. https:\/\/doi.org\/10.1097\/MNH.0000000000000229","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"4975_CR26","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1038\/s41420-019-0203-5","volume":"5","author":"FC Gombedza","year":"2019","unstructured":"Gombedza FC, Shin S, Kanaras YL, Bandyopadhyay BC (2019) Abrogation of store-operated Ca2+ entry protects against crystal-induced ER stress in human proximal tubular cells. Cell Death Discov 5:124. https:\/\/doi.org\/10.1038\/s41420-019-0203-5","journal-title":"Cell Death Discov"},{"issue":"1","key":"4975_CR27","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-37191-5","volume":"9","author":"F Gombedza","year":"2019","unstructured":"Gombedza F, Evans S, Shin S, Awuah Boadi E, Zhang Q, Nie Z, Bandyopadhyay BC (2019) Melamine promotes calcium crystal formation in three-dimensional microfluidic device. Sci Rep 9(1):875. https:\/\/doi.org\/10.1038\/s41598-018-37191-5","journal-title":"Sci Rep"},{"issue":"2","key":"4975_CR28","doi-asserted-by":"publisher","first-page":"e11","DOI":"10.1016\/j.jid.2016.11.020","volume":"137","author":"A Grada","year":"2017","unstructured":"Grada A, Otero-Vinas M, Prieto-Castrillo F, Obagi Z, Falanga V (2017) Research techniques made simple: analysis of collective cell migration using the wound healing assay. J Invest Dermatol 137(2):e11\u2013e16. https:\/\/doi.org\/10.1016\/j.jid.2016.11.020","journal-title":"J Invest Dermatol"},{"issue":"11","key":"4975_CR29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0207672","volume":"13","author":"D Grauzdyt\u0117","year":"2018","unstructured":"Grauzdyt\u0117 D, Pukalskas A, Viranaicken W, El Kalamouni C, Venskutonis PR (2018) Protective effects of Phyllanthus phillyreifolius extracts against hydrogen peroxide induced oxidative stress in HEK293 cells. PLoS One 13(11):e0207672. https:\/\/doi.org\/10.1371\/journal.pone.0207672","journal-title":"PLoS One"},{"issue":"11","key":"4975_CR30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0207672","volume":"13","author":"D Grauzdyt\u0117","year":"2018","unstructured":"Grauzdyt\u0117 D, Pukalskas A, Viranaicken W, El Kalamouni C, Venskutonis PR (2018) Protective effects of Phyllanthus phillyreifolius extracts against hydrogen peroxide induced oxidative stress in HEK293 cells. PLoS One 13(11):e0207672. https:\/\/doi.org\/10.1371\/journal.pone.0207672","journal-title":"PLoS One"},{"issue":"9","key":"4975_CR31","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1021\/np0700164","volume":"70","author":"P Gupta","year":"2007","unstructured":"Gupta P, Yadav DK, Siripurapu KB, Palit G, Maurya R (2007) Constituents of Ocimum sanctum with antistress activity. J Nat Prod 70(9):1410\u20131416. https:\/\/doi.org\/10.1021\/np0700164","journal-title":"J Nat Prod"},{"issue":"4","key":"4975_CR32","doi-asserted-by":"publisher","first-page":"2632","DOI":"10.1074\/jbc.M111.323709","volume":"287","author":"\u00c1 Guti\u00e9rrez-Uzquiza","year":"2012","unstructured":"Guti\u00e9rrez-Uzquiza \u00c1, Arechederra M, Bragado P, Aguirre-Ghiso JA, Porras A (2012) p38\u03b1 mediates cell survival in response to oxidative stress via induction of antioxidant genes: effect on the p70S6K pathway. J Biol Chem 287(4):2632\u20132642. https:\/\/doi.org\/10.1074\/jbc.M111.323709","journal-title":"J Biol Chem"},{"issue":"1","key":"4975_CR33","doi-asserted-by":"publisher","first-page":"161","DOI":"10.3390\/nano12010161","volume":"12","author":"WA Hailan","year":"2022","unstructured":"Hailan WA, Al-Anazi KM, Farah MA, Ali MA, Al-Kawmani AA, Abou-Tarboush FM (2022) Reactive oxygen species-mediated cytotoxicity in liver carcinoma cells induced by silver nanoparticles biosynthesized using Schinus molle extract. Nanomaterials (Basel) 12(1):161. https:\/\/doi.org\/10.3390\/nano12010161","journal-title":"Nanomaterials (Basel)"},{"issue":"3","key":"4975_CR34","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28031193","volume":"28","author":"MR Hasan","year":"2023","unstructured":"Hasan MR, Alotaibi BS, Althafar ZM, Mujamammi AH, Jameela J (2023) An update on the therapeutic anticancer potential of Ocimum sanctum L.: \u201cElixir of life.\u201d Molecules 28(3):1193. https:\/\/doi.org\/10.3390\/molecules28031193","journal-title":"Molecules"},{"issue":"20","key":"4975_CR35","doi-asserted-by":"publisher","first-page":"2938","DOI":"10.1016\/j.yexcr.2011.09.011","volume":"317","author":"G Hernandez","year":"2011","unstructured":"Hernandez G, La H, Fidalgo M, Guerrero A, Zalvide J, Force T, Pombo CM (2011) A novel cardioprotective p38-MAPK\/mTOR pathway. Exp Cell Res 317(20):2938\u20132949","journal-title":"Exp Cell Res"},{"key":"4975_CR36","doi-asserted-by":"publisher","first-page":"9217567","DOI":"10.1155\/2017\/92175678","volume":"2017","author":"N Jamshidi","year":"2017","unstructured":"Jamshidi N, Cohen MM (2017) The Clinical Efficacy and Safety of Tulsi in Humans: A Systematic Review of the Literature. Evid Based Complement Alternat Med 2017:9217567. https:\/\/doi.org\/10.1155\/2017\/92175678","journal-title":"Evid Based Complement Alternat Med"},{"issue":"9","key":"4975_CR37","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22094642","volume":"22","author":"CA Juan","year":"2021","unstructured":"Juan CA, P\u00e9rez de la Lastra JM, Plou FJ, P\u00e9rez-Lebe\u00f1a E (2021) The chemistry of reactive oxygen species (ROS) revisited: outlining their role in biological macromolecules (DNA, lipids and proteins) and induced pathologies. Int J Mol Sci 22(9):4642. https:\/\/doi.org\/10.3390\/ijms22094642","journal-title":"Int J Mol Sci"},{"key":"4975_CR38","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027106","volume":"6","author":"K Kawai","year":"2011","unstructured":"Kawai K, Larson BJ, Ishise H, Carre AL, Nishimoto S, Lorenz HP (2011) Calcium-based nanoparticles accelerate skin wound healing. PLoS One 6:e27106. https:\/\/doi.org\/10.1371\/journal.pone.0027106","journal-title":"PLoS One"},{"issue":"10","key":"4975_CR39","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.3390\/nu10101368","volume":"10","author":"KB Kim","year":"2018","unstructured":"Kim KB, Lee S, Kang I, Kim JH (2018) Momordica charantia ethanol extract attenuates H\u2082O\u2082-induced cell death by its antioxidant and anti-apoptotic properties in human neuroblastoma SK-N-MC cells. Nutrients 10(10):1368. https:\/\/doi.org\/10.3390\/nu10101368","journal-title":"Nutrients"},{"issue":"39","key":"4975_CR40","doi-asserted-by":"publisher","first-page":"36845","DOI":"10.1074\/jbc.M200832200","volume":"277","author":"HK Koul","year":"2002","unstructured":"Koul HK, Menon M, Chaturvedi LS et al (2002) COM crystals activate the p38 mitogen-activated protein kinase signal transduction pathway in renal epithelial cells. J Biol Chem 277(39):36845\u201336852. https:\/\/doi.org\/10.1074\/jbc.M200832200","journal-title":"J Biol Chem"},{"key":"4975_CR41","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1111\/j.1365-2184.1984.tb00611.x","volume":"17","author":"MF Kulesz-Martin","year":"1984","unstructured":"Kulesz-Martin MF, Fabian D, Bertram JS (1984) Differential calcium requirements for growth of mouse skin epithelial and fibroblast cells. Cell Prolif 17:525\u2013533","journal-title":"Cell Prolif"},{"issue":"1","key":"4975_CR42","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.kint.2017.07.030","volume":"93","author":"S Kumar","year":"2018","unstructured":"Kumar S (2018) Cellular and molecular pathways of renal repair after acute kidney injury. Kidney Int 93(1):27\u201340. https:\/\/doi.org\/10.1016\/j.kint.2017.07.030","journal-title":"Kidney Int"},{"issue":"4","key":"4975_CR43","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.jpha.2017.01.005","volume":"7","author":"S Kumar","year":"2017","unstructured":"Kumar S, Singh A, Kumar B (2017) Identification and characterization of phenolics and terpenoids from ethanolic extracts of Phyllanthus species by HPLC-ESI-QTOF-MS\/MS. J Pharm Anal 7(4):214\u2013222. https:\/\/doi.org\/10.1016\/j.jpha.2017.01.005","journal-title":"J Pharm Anal"},{"key":"4975_CR44","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2022.135315","volume":"437","author":"YJ Li","year":"2022","unstructured":"Li YJ, Wei SC, Chu HW, Jian HJ, Anand A, Nain A, Huang YF, Chang HT, Huang CC, Lai JY (2022) Poly\u2011quercetin\u2011based nanoVelcro as a multifunctional wound dressing for effective treatment of chronic wound infections. Chem Eng J 437:135315. https:\/\/doi.org\/10.1016\/j.cej.2022.135315","journal-title":"Chem Eng J"},{"key":"4975_CR45","doi-asserted-by":"publisher","first-page":"132409","DOI":"10.1016\/j.cej.2021.132409","volume":"429","author":"LJ Luo","year":"2022","unstructured":"Luo LJ, Nguyen DD, Matsusaki M, Lai JY (2022) Therapeutic hydrogel sheets programmed with multistage drug delivery for effective treatment of corneal abrasion. Chem Eng J 429:132409. https:\/\/doi.org\/10.1016\/j.cej.2021.132409","journal-title":"Chem Eng J"},{"issue":"3","key":"4975_CR46","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1053\/j.ajkd.2021.05.024","volume":"79","author":"HL MacLaughlin","year":"2022","unstructured":"MacLaughlin HL, Friedman AN, Ikizler TA (2022) Nutrition in kidney disease: core curriculum 2022. Am J Kidney Dis 79(3):437\u2013449. https:\/\/doi.org\/10.1053\/j.ajkd.2021.05.024","journal-title":"Am J Kidney Dis"},{"key":"4975_CR47","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/0014-4827(87)90091-7","volume":"172","author":"I Magee","year":"1987","unstructured":"Magee I, Lytton NA, Watt FM (1987) Calcium-Induced Changes in Cytoskeleton and Motility Cultured Human Keratinocytes. Exp Cell Res 172:43\u201353","journal-title":"Exp Cell Res"},{"issue":"1","key":"4975_CR48","doi-asserted-by":"publisher","first-page":"2237","DOI":"10.1080\/13880209.2022.2132030","volume":"60","author":"A Mishra","year":"2022","unstructured":"Mishra A, Kumar V, Singh A (2022) Deciphering the anti-filarial potential of bioactive compounds from Ocimum sanctum: a combined experimental and computational study. Pharm Biol 60(1):2237\u20132252. https:\/\/doi.org\/10.1080\/13880209.2022.2132030","journal-title":"Pharm Biol"},{"issue":"2","key":"4975_CR49","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1159\/000487671","volume":"4","author":"SR Mulay","year":"2018","unstructured":"Mulay SR, Shi C, Ma X, Anders HJ (2018) Novel Insights into Crystal-Induced Kidney Injury. Kidney Dis (Basel) 4(2):49\u201357. https:\/\/doi.org\/10.1159\/000487671","journal-title":"Kidney Dis (Basel)"},{"issue":"1","key":"4975_CR50","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s43094-020-00161-8","volume":"7","author":"RE Mutha","year":"2021","unstructured":"Mutha RE, Tatiya AU, Surana SJ (2021) Flavonoids as natural phenolic compounds and their role in therapeutics: an overview. Futur J Pharm Sci 7(1):25. https:\/\/doi.org\/10.1186\/s43094-020-00161-8","journal-title":"Futur J Pharm Sci"},{"issue":"9","key":"4975_CR51","doi-asserted-by":"publisher","DOI":"10.3390\/nu13093277","volume":"13","author":"T Naber","year":"2021","unstructured":"Naber T, Purohit S (2021) Chronic kidney disease: role of diet for a reduction in the severity of the disease. Nutrients 13(9):3277. https:\/\/doi.org\/10.3390\/nu13093277","journal-title":"Nutrients"},{"issue":"39","key":"4975_CR52","doi-asserted-by":"publisher","first-page":"395102","DOI":"10.1088\/1361-6528\/aad01f","volume":"29","author":"C Navarro-requena","year":"2018","unstructured":"Navarro-requena C, P\u00e9rez-amodio S (2018) Wound healing-promoting effects stimulated by extracellular calcium and calcium-releasing nanoparticles on dermal fibroblasts. Nanotechnology 29:395102. https:\/\/doi.org\/10.1088\/1361-6528\/aad01f","journal-title":"Nanotechnology"},{"issue":"11","key":"4975_CR53","doi-asserted-by":"publisher","DOI":"10.3390\/cells10113204","volume":"10","author":"B Ning","year":"2021","unstructured":"Ning B, Guo C, Kong A, Li K, Xie Y, Shi H, Gu J (2021) Calcium signaling mediates cell death and crosstalk with autophagy in kidney disease. Cells 10(11):3204. https:\/\/doi.org\/10.3390\/cells10113204","journal-title":"Cells"},{"issue":"3","key":"4975_CR54","doi-asserted-by":"publisher","first-page":"765","DOI":"10.3390\/ijms19030765","volume":"19","author":"MC Nirumand","year":"2018","unstructured":"Nirumand MC, Hajialyani M, Rahimi R et al (2018) Dietary Plants for the Prevention and Management of Kidney Stones: Preclinical and Clinical Evidence and Molecular Mechanisms. Int J Mol Sci 19(3):765. https:\/\/doi.org\/10.3390\/ijms19030765","journal-title":"Int J Mol Sci"},{"issue":"7","key":"4975_CR55","doi-asserted-by":"publisher","first-page":"95","DOI":"10.4103\/0973-7847.65323","volume":"4","author":"P Pattanayak","year":"2010","unstructured":"Pattanayak P, Behera P, Das D, Panda SK (2010) Ocimum sanctum Linn. A reservoir plant for therapeutic applications: An overview. Pharmacogn Rev 4(7):95. https:\/\/doi.org\/10.4103\/0973-7847.65323","journal-title":"Pharmacogn Rev"},{"issue":"12","key":"4975_CR56","doi-asserted-by":"publisher","first-page":"6195","DOI":"10.3390\/ijms22126195","volume":"22","author":"F Protasi","year":"2021","unstructured":"Protasi F, Pietrangelo L, Boncompagni S (2021) Improper remodeling of organelles deputed to Ca2\u2009+\u2009handling and aerobic ATP production underlies muscle dysfunction in ageing. Int J Mol Sci 22(12):6195. https:\/\/doi.org\/10.3390\/ijms22126195","journal-title":"Int J Mol Sci"},{"issue":"1","key":"4975_CR57","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1007\/s00240-019-01143-z","volume":"48","author":"S Qi","year":"2020","unstructured":"Qi S, Wang Q, Xie B, Chen Y, Zhang Z, Xu Y (2020) P38 MAPK signaling pathway mediates COM crystal-induced crystal adhesion change in rat renal tubular epithelial cells. Urolithiasis 48(1):9\u201318. https:\/\/doi.org\/10.1007\/s00240-019-01143-z","journal-title":"Urolithiasis"},{"key":"4975_CR58","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/278925","author":"C Ramteke","year":"2012","unstructured":"Ramteke C, Chakrabarti T, Sarangi BK, Pandey R-A (2012) Synthesis of silver nanoparticles from the aqueous extract of leaves of Ocimum sanctum for enhanced antibacterial activity. J Chem. https:\/\/doi.org\/10.1155\/2013\/278925","journal-title":"J Chem"},{"issue":"1","key":"4975_CR59","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1007\/BF02893064","volume":"20","author":"K Reshma","year":"2005","unstructured":"Reshma K, Ashalatha VR, Dinesh M, Vasudevan D (2005) Effect of ocimum flavonoids as a radioprotector on the erythrocyte antioxidants in oral cancer. Indian J Clin Biochem 20(1):160\u2013164. https:\/\/doi.org\/10.1007\/BF02893064","journal-title":"Indian J Clin Biochem"},{"key":"4975_CR60","doi-asserted-by":"publisher","first-page":"100379","DOI":"10.1016\/j.rsurfi.2024.100379","volume":"18","author":"M Sahu","year":"2025","unstructured":"Sahu M, Kamakshi, Sahoo J et al (2025) Synthesis and characterization of ethanolic extract of Nutgalls of the plant Quercus infectoria silver nitrate nanoparticles incorporated chitosan based scaffold, and their in-silico study for wound healing activity. Results Surf Interfaces 18:100379. https:\/\/doi.org\/10.1016\/j.rsurfi.2024.100379","journal-title":"Results Surf Interfaces"},{"issue":"3","key":"4975_CR61","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109874","volume":"37","author":"G Scepanovic","year":"2021","unstructured":"Scepanovic G, Hunter MV, Kafri R, Fernandez-Gonzalez R (2021) p38-mediated cell growth and survival drive rapid embryonic wound repair. Cell Rep 37(3):109874. https:\/\/doi.org\/10.1016\/j.celrep.2021.109874","journal-title":"Cell Rep"},{"issue":"8","key":"4975_CR62","doi-asserted-by":"publisher","first-page":"1712","DOI":"10.1111\/j.1476-5381.2012.02126.x","volume":"167","author":"H Schleifer","year":"2012","unstructured":"Schleifer H, Doleschal B, Lichtenegger M et al (2012) Novel pyrazole compounds for pharmacological discrimination between receptor-operated and store-operated Ca(2+) entry pathways. Br J Pharmacol 167(8):1712\u20131722. https:\/\/doi.org\/10.1111\/j.1476-5381.2012.02126.x","journal-title":"Br J Pharmacol"},{"issue":"24","key":"4975_CR63","doi-asserted-by":"publisher","first-page":"21989","DOI":"10.1074\/jbc.M302650200","volume":"278","author":"GD Sharma","year":"2003","unstructured":"Sharma GD, He J, Bazan HE (2003) p38 and ERK1\/2 coordinate cellular migration and proliferation in epithelial wound healing: evidence of cross-talk activation between MAP kinase cascades. J Biol Chem 278(24):21989\u201321997. https:\/\/doi.org\/10.1074\/jbc.M302650200","journal-title":"J Biol Chem"},{"issue":"16","key":"4975_CR64","doi-asserted-by":"publisher","DOI":"10.1172\/JCI145693","volume":"131","author":"K Shiizaki","year":"2021","unstructured":"Shiizaki K, Tsubouchi A, Miura Y et al (2021) Calcium phosphate microcrystals in the renal tubular fluid accelerate chronic kidney disease progression. J Clin Invest 131(16):e145693. https:\/\/doi.org\/10.1172\/JCI145693","journal-title":"J Clin Invest"},{"key":"4975_CR65","doi-asserted-by":"publisher","first-page":"109484","DOI":"10.1016\/j.cellsig.2019.109484","volume":"67","author":"S Shin","year":"2020","unstructured":"Shin S, Gombedza FC, Bandyopadhyay BC (2020) l-ornithine activates Ca2+ signaling to exert its protective function on human proximal tubular cells. Cell Signal 67:109484. https:\/\/doi.org\/10.1016\/j.cellsig.2019.109484","journal-title":"Cell Signal"},{"key":"4975_CR66","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.109853","volume":"117","author":"S Shin","year":"2023","unstructured":"Shin S, Awuah Boadi E, Shah S, Ezell M, Li P, Bandyopadhyay BC (2023) Anti-inflammatory role of extracellular l-arginine through calcium sensing receptor in human renal proximal tubular epithelial (HK-2) cells. Int Immunopharmacol 117:109853. https:\/\/doi.org\/10.1016\/j.intimp.2023.109853","journal-title":"Int Immunopharmacol"},{"issue":"2","key":"4975_CR67","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.gendis.2021.04.006","volume":"9","author":"S Shin","year":"2021","unstructured":"Shin S, Ibeh CL, Awuah Boadi E, Choi BE, Roy SK, Bandyopadhyay BC (2021) Hypercalciuria switches Ca2+ signaling in proximal tubular cells, induces oxidative damage to promote calcium nephrolithiasis. Genes Dis 9(2):531\u2013548. https:\/\/doi.org\/10.1016\/j.gendis.2021.04.006","journal-title":"Genes Dis"},{"issue":"9","key":"4975_CR68","doi-asserted-by":"publisher","first-page":"6039","DOI":"10.1021\/acsomega.7b00510","volume":"2","author":"XY Sun","year":"2017","unstructured":"Sun XY, Xu M, Ouyang JM (2017) Effect of Crystal Shape and Aggregation of Calcium Oxalate Monohydrate on Cellular Toxicity in Renal Epithelial Cells. ACS Omega 2(9):6039\u20136052. https:\/\/doi.org\/10.1021\/acsomega.7b00510","journal-title":"ACS Omega"},{"issue":"12","key":"4975_CR69","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.3390\/nu2121231","volume":"2","author":"R Tsao","year":"2010","unstructured":"Tsao R (2010) Chemistry and biochemistry of dietary polyphenols. Nutrients 2(12):1231\u20131246. https:\/\/doi.org\/10.3390\/nu2121231","journal-title":"Nutrients"},{"key":"4975_CR70","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.101713","volume":"32","author":"WL Wang","year":"2025","unstructured":"Wang WL, Lai YH, Huang CH, Lai JY, Yao CH (2025) Lumbrokinase-containing gelatin nanofibers with multiple bioactivities for effective skin wound healing. Mater Today Bio 32:101713. https:\/\/doi.org\/10.1016\/j.mtbio.2025.101713","journal-title":"Mater Today Bio"},{"issue":"9","key":"4975_CR71","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.200223","volume":"10","author":"HN Wilkinson","year":"2020","unstructured":"Wilkinson HN, Hardman MJ (2020) Wound healing: cellular mechanisms and pathological outcomes. Open Biol 10(9):200223. https:\/\/doi.org\/10.1098\/rsob.200223","journal-title":"Open Biol"},{"issue":"26","key":"4975_CR72","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202302174","volume":"10","author":"CJ Yang","year":"2023","unstructured":"Yang CJ, Nguyen DD, Lai JY (2023) Poly(l-Histidine)\u2011mediated on\u2011demand therapeutic delivery of roughened ceria nanocages for treatment of chemical eye injury. Adv Sci (Weinh) 10(26):e2302174. https:\/\/doi.org\/10.1002\/advs.202302174","journal-title":"Adv Sci (Weinh)"},{"issue":"1","key":"4975_CR73","doi-asserted-by":"publisher","first-page":"C27","DOI":"10.1152\/ajpcell.00225.2016","volume":"313","author":"AJ Yiu","year":"2017","unstructured":"Yiu AJ, Ibeh CL, Roy SK, Bandyopadhyay BC (2017) Melamine induces Ca2+-sensing receptor activation and elicits apoptosis in proximal tubular cells. Am J Physiol Cell Physiol 313(1):C27\u2013C41. https:\/\/doi.org\/10.1152\/ajpcell.00225.2016","journal-title":"Am J Physiol Cell Physiol"},{"key":"4975_CR74","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1113\/jphysiol.1992.sp019419","volume":"458","author":"S Yoshida","year":"1992","unstructured":"Yoshida S, Plant S (1992) Mechanism of release of Ca2\u2009+\u2009from intracellular stores in response to ionomycin in oocytes of the frog Xenopus laevis. J Physiol 458:307\u2013318. https:\/\/doi.org\/10.1113\/jphysiol.1992.sp019419","journal-title":"J Physiol"},{"issue":"8","key":"4975_CR75","doi-asserted-by":"publisher","first-page":"7816","DOI":"10.1021\/acsomega.2c07584","volume":"8","author":"BX Yu","year":"2023","unstructured":"Yu BX, Zhang YH, Li CY et al (2023) Cell protection and crystal endocytosis inhibition by sulfated Laminaria polysaccharides against nano-COM-induced oxidative damage in renal epithelial cells. ACS Omega 8(8):7816\u20137828. https:\/\/doi.org\/10.1021\/acsomega.2c07584","journal-title":"ACS Omega"},{"issue":"7","key":"4975_CR76","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21072346","volume":"21","author":"J Yue","year":"2020","unstructured":"Yue J, L\u00f3pez JM (2020) Understanding MAPK signaling pathways in apoptosis. Int J Mol Sci 21(7):2346. https:\/\/doi.org\/10.3390\/ijms21072346","journal-title":"Int J Mol Sci"},{"key":"4975_CR77","doi-asserted-by":"publisher","first-page":"4277","DOI":"10.2147\/IJN.S198644","volume":"14","author":"YW Zhao","year":"2019","unstructured":"Zhao YW, Guo D, Li CY, Ouyang JM (2019) Comparison of the adhesion of calcium oxalate monohydrate to HK-2 cells before and after repair using tea polysaccharides. Int J Nanomed 14:4277\u20134292. https:\/\/doi.org\/10.2147\/IJN.S198644","journal-title":"Int J Nanomed"}],"container-title":["3 Biotech"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13205-026-04975-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13205-026-04975-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13205-026-04975-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T09:37:17Z","timestamp":1786354637000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13205-026-04975-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,15]]},"references-count":75,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["4975"],"URL":"https:\/\/doi.org\/10.1007\/s13205-026-04975-w","relation":{},"ISSN":["2190-572X","2190-5738"],"issn-type":[{"value":"2190-572X","type":"print"},{"value":"2190-5738","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,15]]},"assertion":[{"value":"4 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that there is no conflict of interest.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This scientific research adheres to the highest ethical standards, including the principles of honesty, integrity, and transparency. Data collection, analysis, and reporting were performed accurately and without bias. Any potential conflicts of interest have been disclosed, and the research was carried out in compliance with relevant ethical guidelines and regulations.","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"330"}}