{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:04:04Z","timestamp":1787771044446,"version":"build-2784847793"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2012,11,12]],"date-time":"2012-11-12T00:00:00Z","timestamp":1352678400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Protein Cell"],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1007\/s13238-012-2081-y","type":"journal-article","created":{"date-parts":[[2012,11,12]],"date-time":"2012-11-12T02:49:57Z","timestamp":1352688597000},"page":"130-141","source":"Crossref","is-referenced-by-count":101,"title":["MicroRNA-548 down-regulates host antiviral response via direct targeting of IFN-\u03bb1"],"prefix":"10.1093","volume":"4","author":[{"given":"Yongkui","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajia","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiupeng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Ao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yushun","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,11,12]]},"reference":[{"key":"2081_CR1","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.antiviral.2008.06.016","volume":"80","author":"GM Almeida","year":"2008","unstructured":"Almeida, G.M., de Oliveira, D.B., Magalhaes, C.L., Bonjardim, C.A., Ferreira, P.C., and Kroon, E.G. (2008). Antiviral activity of type I interferons and interleukins 29 and 28a (type III interferons) against Apeu virus. Antiviral Res 80, 302\u2013308.","journal-title":"Antiviral Res"},{"key":"2081_CR2","doi-asserted-by":"crossref","first-page":"4501","DOI":"10.1128\/JVI.80.9.4501-4509.2006","volume":"80","author":"N Ank","year":"2006","unstructured":"Ank, N., West, H., Bartholdy, C., Eriksson, K., Thomsen, A.R., and Paludan, S.R. (2006). Lambda interferon (IFN-lambda), a type III IFN, is induced by viruses and IFNs and displays potent antiviral activity against select virus infections in vivo. J Virol 80, 4501\u20134509.","journal-title":"J Virol"},{"key":"2081_CR3","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1089\/jir.2009.0049","volume":"30","author":"P Bandi","year":"2010","unstructured":"Bandi, P., Pagliaccetti, N.E., and Robek, M.D. (2010). Inhibition of type III interferon activity by orthopoxvirus immunomodulatory proteins. J Interferon Cytokine Res 30, 123\u2013134.","journal-title":"J Interferon Cytokine Res"},{"key":"2081_CR4","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","volume":"116","author":"DP Bartel","year":"2004","unstructured":"Bartel, D.P. (2004). MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116, 281\u2013297.","journal-title":"Cell"},{"key":"2081_CR5","doi-asserted-by":"crossref","first-page":"7059","DOI":"10.1128\/JVI.75.15.7059-7066.2001","volume":"75","author":"CB Bigger","year":"2001","unstructured":"Bigger, C.B., Brasky, K.M., and Lanford, R.E. (2001). DNA microarray analysis of chimpanzee liver during acute resolving hepatitis C virus infection. J Virol 75, 7059\u20137066.","journal-title":"J Virol"},{"key":"2081_CR6","doi-asserted-by":"crossref","first-page":"e179","DOI":"10.1093\/nar\/gni178","volume":"33","author":"C Chen","year":"2005","unstructured":"Chen, C., Ridzon, D.A., Broomer, A.J., Zhou, Z., Lee, D.H., Nguyen, J.T., Barbisin, M., Xu, N.L., Mahuvakar, V.R., Andersen, M.R., et al. (2005). Real-time quantification of microRNAs by stem-loop RT-PCR. Nucleic Acids Res 33, e179.","journal-title":"Nucleic Acids Res"},{"key":"2081_CR7","volume-title":"Interferon-\u025b","author":"DC Conklin","year":"2002","unstructured":"Conklin, D.C., Grant, F.J., Rixon, M.W., and Kindsvogel, W. (2002). Interferon-\u025b. U.S. Patent 6329175."},{"key":"2081_CR8","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1101\/gad.1184404","volume":"18","author":"JG Doench","year":"2004","unstructured":"Doench, J.G., and Sharp, P.A. (2004). Specificity of microRNA target selection in translational repression. Genes Dev 18, 504\u2013511.","journal-title":"Genes Dev"},{"key":"2081_CR9","doi-asserted-by":"crossref","first-page":"5238","DOI":"10.1073\/pnas.87.14.5238","volume":"87","author":"JM Farber","year":"1990","unstructured":"Farber, J.M. (1990). A macrophage mRNA selectively induced by gamma-interferon encodes a member of the platelet factor 4 family of cytokines. Proc Natl Acad Sci U S A 87, 5238\u20135242.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2081_CR10","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1038\/nature05732","volume":"446","author":"MU Gack","year":"2007","unstructured":"Gack, M.U., Shin, Y.C., Joo, C.H., Urano, T., Liang, C., Sun, L., Takeuchi, O., Akira, S., Chen, Z., Inoue, S., et al. (2007). TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity. Nature 446, 916\u2013920.","journal-title":"Nature"},{"key":"2081_CR11","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0092-8674(01)00431-7","volume":"106","author":"A Grishok","year":"2001","unstructured":"Grishok, A., Pasquinelli, A.E., Conte, D., Li, N., Parrish, S., Ha, I., Baillie, D.L., Fire, A., Ruvkun, G., and Mello, C.C. (2001). Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing. Cell 106, 23\u201334.","journal-title":"Cell"},{"key":"2081_CR12","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.virusres.2007.03.006","volume":"126","author":"SH Hong","year":"2007","unstructured":"Hong, S.H., Cho, O., Kim, K., Shin, H.J., Kotenko, S.V., and Park, S. (2007). Effect of interferon-lambda on replication of hepatitis B virus in human hepatoma cells. Virus Res 126, 245\u2013249.","journal-title":"Virus Res"},{"key":"2081_CR13","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1002\/hep.23660","volume":"52","author":"J Huang","year":"2010","unstructured":"Huang, J., Wang, Y., Guo, Y., and Sun, S. (2010). Down-regulated microRNA-152 induces aberrant DNA methylation in hepatitis B virus-related hepatocellular carcinoma by targeting DNA methyltransferase 1. Hepatology 52, 60\u201370.","journal-title":"Hepatology"},{"key":"2081_CR14","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1126\/science.1062961","volume":"293","author":"G Hutvagner","year":"2001","unstructured":"Hutvagner, G., McLachlan, J., Pasquinelli, A.E., Balint, E., Tuschl, T., and Zamore, P.D. (2001). A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA. Science 293, 834\u2013838.","journal-title":"Science"},{"key":"2081_CR15","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1126\/science.1073827","volume":"297","author":"G Hutvagner","year":"2002","unstructured":"Hutvagner, G., and Zamore, P.D. (2002). A microRNA in a multiple-turnover RNAi enzyme complex. Science 297, 2056\u20132060.","journal-title":"Science"},{"key":"2081_CR16","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.febslet.2010.01.036","volume":"584","author":"Y Ji","year":"2010","unstructured":"Ji, Y., He, Y., Liu, L., and Zhong, X. (2010). MiRNA-26b regulates the expression of cyclooxygenase-2 in desferrioxamine-treated CNE cells. FEBS Lett 584, 961\u2013967.","journal-title":"FEBS Lett"},{"key":"2081_CR17","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/ni875","volume":"4","author":"SV Kotenko","year":"2003","unstructured":"Kotenko, S.V., Gallagher, G., Baurin, V.V., Lewis-Antes, A., Shen, M., Shah, N.K., Langer, J.A., Sheikh, F., Dickensheets, H., and Donnelly, R.P. (2003). IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex. Nat Immunol 4, 69\u201377.","journal-title":"Nat Immunol"},{"key":"2081_CR18","doi-asserted-by":"crossref","first-page":"39765","DOI":"10.1074\/jbc.M102502200","volume":"276","author":"DW LaFleur","year":"2001","unstructured":"LaFleur, D.W., Nardelli, B., Tsareva, T., Mather, D., Feng, P., Semenuk, M., Taylor, K., Buergin, M., Chinchilla, D., Roshke, V., et al. (2001). Interferon-kappa, a novel type I interferon expressed in human keratinocytes. J Biol Chem 276, 39765\u201339771.","journal-title":"J Biol Chem"},{"key":"2081_CR19","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nature01957","volume":"425","author":"Y Lee","year":"2003","unstructured":"Lee, Y., Ahn, C., Han, J., Choi, H., Kim, J., Yim, J., Lee, J., Provost, P., Radmark, O., Kim, S., et al. (2003). The nuclear RNase III Drosha initiates microRNA processing. Nature 425, 415\u2013419.","journal-title":"Nature"},{"key":"2081_CR20","doi-asserted-by":"crossref","first-page":"8051","DOI":"10.1128\/JVI.02491-09","volume":"84","author":"X Lei","year":"2010","unstructured":"Lei, X., Liu, X., Ma, Y., Sun, Z., Yang, Y., Jin, Q., He, B., and Wang, J. (2010). The 3C protein of enterovirus 71 inhibits retinoid acid-inducible gene I-mediated interferon regulatory factor 3 activation and type I interferon responses. J Virol 84, 8051\u20138061.","journal-title":"J Virol"},{"key":"2081_CR21","doi-asserted-by":"crossref","first-page":"8811","DOI":"10.1128\/JVI.00447-11","volume":"85","author":"X Lei","year":"2011","unstructured":"Lei, X., Sun, Z., Liu, X., Jin, Q., He, B., and Wang, J. (2011). Cleavage of the adaptor protein TRIF by enterovirus 71 3C inhibits antiviral responses mediated by Toll-like receptor 3. J Virol 85, 8811\u20138818.","journal-title":"J Virol"},{"key":"2081_CR22","doi-asserted-by":"crossref","first-page":"17717","DOI":"10.1073\/pnas.0508531102","volume":"102","author":"XD Li","year":"2005","unstructured":"Li, X.D., Sun, L., Seth, R.B., Pineda, G., and Chen, Z.J. (2005). Hepatitis C virus protease NS3\/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity. Proc Natl Acad Sci U S A 102, 17717\u201317722.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2081_CR23","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.compbiolchem.2010.08.001","volume":"34","author":"S Lin","year":"2010","unstructured":"Lin, S., Cheung, W.K., Chen, S., Lu, G., Wang, Z., Xie, D., Li, K., Lin, M.C., and Kung, H.F. (2010). Computational identification and characterization of primate-specific microRNAs in human genome. Comput Biol Chem 34, 232\u2013241.","journal-title":"Comput Biol Chem"},{"key":"2081_CR24","doi-asserted-by":"crossref","first-page":"6001","DOI":"10.1073\/pnas.0601523103","volume":"103","author":"YM Loo","year":"2006","unstructured":"Loo, Y.M., Owen, D.M., Li, K., Erickson, A.K., Johnson, C.L., Fish, P.M., Carney, D.S., Wang, T., Ishida, H., Yoneyama, M., et al. (2006). Viral and therapeutic control of IFN-beta promoter stimulator 1 during hepatitis C virus infection. Proc Natl Acad Sci U S A 103, 6001\u20136006.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2081_CR25","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1126\/science.1090599","volume":"303","author":"E Lund","year":"2004","unstructured":"Lund, E., Guttinger, S., Calado, A., Dahlberg, J.E., and Kutay, U. (2004). Nuclear export of microRNA precursors. Science 303, 95\u201398.","journal-title":"Science"},{"key":"2081_CR26","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.4161\/cbt.7.7.6192","volume":"7","author":"SG Maher","year":"2008","unstructured":"Maher, S.G., Sheikh, F., Scarzello, A.J., Romero-Weaver, A.L., Baker, D.P., Donnelly, R.P., and Gamero, A.M. (2008). IFNalpha and IFNlambda differ in their antiproliferative effects and duration of JAK\/STAT signaling activity. Cancer Biol Ther 7, 1109\u20131115.","journal-title":"Cancer Biol Ther"},{"key":"2081_CR27","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1002\/hep.24580","volume":"54","author":"S Marukian","year":"2011","unstructured":"Marukian, S., Andrus, L., Sheahan, T.P., Jones, C.T., Charles, E.D., Ploss, A., Rice, C.M., and Dustin, L.B. (2011). Hepatitis C virus induces interferon-lambda and interferon-stimulated genes in primary liver cultures. Hepatology 54, 1913\u20131923.","journal-title":"Hepatology"},{"key":"2081_CR28","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.canlet.2005.06.044","volume":"229","author":"EL Milliken","year":"2005","unstructured":"Milliken, E.L., Zhang, X., Flask, C., Duerk, J.L., MacDonald, P.N., and Keri, R.A. (2005). EB1089, a vitamin D receptor agonist, reduces proliferation and decreases tumor growth rate in a mouse model of hormone-induced mammary cancer. Cancer Lett 229, 205\u2013215.","journal-title":"Cancer Lett"},{"key":"2081_CR29","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1126\/science.8009221","volume":"264","author":"U Muller","year":"1994","unstructured":"Muller, U., Steinhoff, U., Reis, L.F., Hemmi, S., Pavlovic, J., Zinkernagel, R.M., and Aguet, M. (1994). Functional role of type I and type II interferons in antiviral defense. Science 264, 1918\u20131921.","journal-title":"Science"},{"key":"2081_CR30","doi-asserted-by":"crossref","first-page":"3434","DOI":"10.4049\/jimmunol.179.6.3434","volume":"179","author":"PI Osterlund","year":"2007","unstructured":"Osterlund, P.I., Pietila, T.E., Veckman, V., Kotenko, S.V., and Julkunen, I. (2007). IFN regulatory factor family members differentially regulate the expression of type III IFN (IFN-lambda) genes. J Immunol 179, 3434\u20133442.","journal-title":"J Immunol"},{"key":"2081_CR31","volume-title":"Hepatology","author":"H Park","year":"2012","unstructured":"Park, H., Serti, E., Eke, O., Muchmore, B., Prokunina-Olsson, L., Capone, S., Folgori, A., and Rehermann, B. (2012). IL-29 is the dominant type III interferon produced by hepatocytes during acute hepatitis C virus infection. Hepatology. (In Press)."},{"key":"2081_CR32","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0168-8278(86)80152-0","volume":"3","author":"C Pasquinelli","year":"1986","unstructured":"Pasquinelli, C., Laur\u00e9, F., Chatenoud, L., Beaurin, G., Gazengel, C., Bismuth, H., Degos, F., Tiollais, P., Bach, J., and Br\u00e9chot, C. (1986). Hepatitis B virus DNA in mononuclear blood cells. A frequent event in hepatitis B surface antigen-positive and -negative patients with acute and chronic liver disease. J Hepatol 3, 95\u2013103.","journal-title":"J Hepatol"},{"key":"2081_CR33","first-page":"S9-4","volume":"24","author":"S Pestka","year":"1997","unstructured":"Pestka, S. (1997). The human interferon-alpha species and hybrid proteins. Semin Oncol 24, S9-4\u2013S9-17.","journal-title":"Semin Oncol"},{"key":"2081_CR34","doi-asserted-by":"crossref","first-page":"e203","DOI":"10.1371\/journal.pone.0000203","volume":"2","author":"J Piriyapongsa","year":"2007","unstructured":"Piriyapongsa, J., and Jordan, I.K. (2007). A family of human microRNA genes from miniature inverted-repeat transposable elements. PLoS One 2, e203.","journal-title":"PLoS One"},{"key":"2081_CR35","doi-asserted-by":"crossref","first-page":"3851","DOI":"10.1128\/JVI.79.6.3851-3854.2005","volume":"79","author":"MD Robek","year":"2005","unstructured":"Robek, M.D., Boyd, B.S., and Chisari, F.V. (2005). Lambda interferon inhibits hepatitis B and C virus replication. J Virol 79, 3851\u20133854.","journal-title":"J Virol"},{"key":"2081_CR36","doi-asserted-by":"crossref","first-page":"7034","DOI":"10.1073\/pnas.0707882105","volume":"105","author":"M Sarasin-Filipowicz","year":"2008","unstructured":"Sarasin-Filipowicz, M., Oakeley, E.J., Duong, F.H., Christen, V., Terracciano, L., Filipowicz, W., and Heim, M.H. (2008). Interferon signaling and treatment outcome in chronic hepatitis C. Proc Natl Acad Sci U S A 105, 7034\u20137039.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2081_CR37","doi-asserted-by":"crossref","first-page":"44312","DOI":"10.1074\/jbc.M307089200","volume":"278","author":"S Saxena","year":"2003","unstructured":"Saxena, S., Jonsson, Z.O., and Dutta, A. (2003). Small RNAs with imperfect match to endogenous mRNA repress translation. Implications for off-target activity of small inhibitory RNA in mammalian cells. J Biol Chem 278, 44312\u201344319.","journal-title":"J Biol Chem"},{"key":"2081_CR38","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/ni873","volume":"4","author":"P Sheppard","year":"2003","unstructured":"Sheppard, P., Kindsvogel, W., Xu, W., Henderson, K., Schlutsmeyer, S., Whitmore, T.E., Kuestner, R., Garrigues, U., Birks, C., Roraback, J., et al. (2003). IL-28, IL-29 and their class II cytokine receptor IL-28R. Nat Immunol 4, 63\u201368.","journal-title":"Nat Immunol"},{"key":"2081_CR39","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.4049\/jimmunol.174.4.1932","volume":"174","author":"J Siren","year":"2005","unstructured":"Siren, J., Pirhonen, J., Julkunen, I., and Matikainen, S. (2005). IFN-alpha regulates TLR-dependent gene expression of IFN-alpha, IFN-beta, IL-28, and IL-29. J Immunol 174, 1932\u20131937.","journal-title":"J Immunol"},{"key":"2081_CR40","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/j.yexcr.2008.12.010","volume":"315","author":"A Strillacci","year":"2009","unstructured":"Strillacci, A., Griffoni, C., Sansone, P., Paterini, P., Piazzi, G., Lazzarini, G., Spisni, E., Pantaleo, M.A., Biasco, G., and Tomasi, V. (2009). MiR-101 downregulation is involved in cyclooxygenase-2 overexpression in human colon cancer cells. Exp Cell Res 315, 1439\u20131447.","journal-title":"Exp Cell Res"},{"key":"2081_CR41","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/cmi.2010.36","volume":"7","author":"X Wang","year":"2010","unstructured":"Wang, X., Li, Y., Mao, A., Li, C., and Tien, P. (2010). Hepatitis B virus X protein suppresses virus-triggered IRF3 activation and IFN-beta induction by disrupting the VISA-associated complex. Cell Mol Immunol 7, 341\u2013348.","journal-title":"Cell Mol Immunol"},{"key":"2081_CR42","doi-asserted-by":"crossref","first-page":"e1985","DOI":"10.1371\/journal.pone.0001985","volume":"3","author":"W Li","year":"2008","unstructured":"Li, W., Liu, Y., Mukhtar, M.M., Gong, R., Pan, Y., Rasool, S.T., Gao, Y., Kang, L., Hao, Q., Peng, G., et al. (2008). Activation of interleukin-32 pro-inflammatory pathway in response to influenza A virus infection. PLoS ONE 3, e1985.","journal-title":"PLoS ONE"},{"key":"2081_CR43","volume-title":"Cancer Lett.","author":"XY Yang","year":"2012","unstructured":"Yang, X.Y., Li, Y.X., Li, M., Zhang, L., Feng, L.X., and Zhang, N. (2012). Hyaluronic acid-coated nanostructured lipid carriers for targeting paclitaxel to cancer. Cancer Lett. (In Press)."},{"key":"2081_CR44","doi-asserted-by":"crossref","first-page":"4844","DOI":"10.4049\/jimmunol.1100998","volume":"187","author":"Y Yu","year":"2011","unstructured":"Yu, Y., Gong, R., Mu, Y., Chen, Y., Zhu, C., Sun, Z., Chen, M., Liu, Y., Zhu, Y., and Wu, J. (2011). Hepatitis B virus induces a novel inflammation network involving three inflammatory factors, IL-29, IL-8, and cyclooxygenase-2. J Immunol 187, 4844\u20134860.","journal-title":"J Immunol"},{"key":"2081_CR45","doi-asserted-by":"crossref","first-page":"279","DOI":"10.4049\/jimmunol.1103405","volume":"189","author":"X Yue","year":"2012","unstructured":"Yue, X., Wang, H., Zhao, F., Liu, S., Wu, J., Ren, W., and Zhu, Y. (2012). Hepatitis B virus-induced calreticulin protein is involved in IFN resistance. J Immunol 189, 279\u2013286.","journal-title":"J Immunol"},{"key":"2081_CR46","doi-asserted-by":"crossref","first-page":"9779","DOI":"10.1073\/pnas.1630797100","volume":"100","author":"Y Zeng","year":"2003","unstructured":"Zeng, Y., Yi, R., and Cullen, B.R. (2003). MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms. Proc Natl Acad Sci U S A 100, 9779\u20139784.","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Protein & Cell"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13238-012-2081-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13238-012-2081-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13238-012-2081-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T11:40:29Z","timestamp":1676374829000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/proteincell\/article\/4\/2\/130\/6874350"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,12]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["2081"],"URL":"https:\/\/doi.org\/10.1007\/s13238-012-2081-y","relation":{},"ISSN":["1674-800X","1674-8018"],"issn-type":[{"value":"1674-800X","type":"print"},{"value":"1674-8018","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,12]]}}}